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This work investigated the efficiency of CoFe2O4 nanoparticles in removing diclofenac and naproxen drugs from aqueous solutions. At first, the Taguchi method was performed to choose the most important factors among the investigated factors affecting the removal efficacy of these drugs. Afterward, the optimal conditions of the effective factors were investigated and modeled by the central composite design-based response surface method. The results revealed that the maximum drug removal was obtained at pH = 7, temperature of 25 °C, adsorbent dosage of 215 mg, sonication time of 21 min, and diclofenac and naproxen concentrations of 15 mg L−1. The removal efficacy of diclofenac and naproxen under these optimal conditions was 99.42 % and 95.11 %, respectively. Based on the results, it is concluded that CoFe2O4 nanoparticles can be applied as an easy-available and effective adsorbent for removing diclofenac and naproxen from water samples.

Composite gels are a type of soft matter, which contains a continuous three-dimensional crosslinked network and has been embedded with non-gel materials. Compared to pure gels, composite gels show high flexibility and tunability in properties and hence have attracted extensive interest in applications ranging from cancer therapy to tissue engineering. In this study, we incorporated triethylenetetramine (TETA)-functionalized cobalt ferrite nanoparticles (ANPs) into a hydrogel consisting of sodium alginate (SA) and methyl cellulose (MC), and examined the resulting composite gels for controlled drug release. The structural, thermal, and morphological aspects of the composite gels were characterized to confirm successful nanoparticle incorporation. Swelling and degradation data demonstrated the pH-responsiveness and enhanced stability of the composite gels. Along with their controlled drug release profiles and their ROS-generating capacity, our composite gels warrant further development as promising bioactive carriers for pharmaceutical applications., Competing Interests: Declaration of competing interest The authors declare no conflict of interest., (Copyright © 2025. Published by Elsevier B.V.)

Cobalt ferrite CoFe 2 O 4 catalyst was fabricated and systematically investigated as an efficient peroxymonosulfate (PMS, HSO 5 - ) activator for the degradation of recalcitrant organic contaminants (ROCs) in water treatment. Both SO 4 - and OH on the surface of catalyst were unveiled to be primarily responsible for bisphenol A (BPA) degradation by a comprehensive study using electron paramagnetic resonance (EPR), radical scavengers and quantification of SO 4 - , and the negligible contribution of singlet oxygen ( 1 O 2 ) was also observed. BPA degradation was accelerated in the presence of humic acid, and it increased first but then decreased with the further addition of fulvic acid. Moreover, the presence of chloride and bicarbonate ions can enhance both BPA and TOC removal. The toxicity of the target aqueous solution ascended slowly at the early stage but then declined dramatically and almost vanished as the reaction proceeded. The removal efficiencies of other typical ROCs (clofibric acid, 2,4-dichlorophenol, etc.) and the decontamination of natural surface water spiked with BPA were also evaluated. This CoFe 2 O 4 /PMS process could be well applied as a safe, efficient, and sustainable approach for ROCs remediation in complex wastewater matrix., (Copyright © 2020 Elsevier B.V. All rights reserved.)

Magnetic hyperthermia (MHT) is a promising approach for cancer therapy. However, a systematic MHT characterization as function of temperature on the therapeutic efficiency is barely analyzed. Here, we first perform comparative temperature-dependent analysis of the cobalt ferrite nanoparticles-mediated MHT effectiveness in two murine tumors models - breast (4T1) and colon (CT26) cancer in vitro and in vivo. The overall MHT killing capacity in vitro increased with the temperature and CT26 cells were more sensitive than 4T1 when heated to 43 °C. Well in line with the in vitro data, such heating cured non-metastatic CT26 tumors in vivo, while only inhibiting metastatic 4T1 tumor growth without improving the overall survival. High-temperature MHT (>47 °C) resulted in complete 4T1 primary tumor clearance, 25-40% long-term survival rates, and, importantly, more effective prevention of metastasis comparing to surgical extraction. Thus, the specific MHT temperature must be defined for each tumor individually to ensure a successful antitumor therapy., (Copyright © 2020 Elsevier Inc. All rights reserved.)

Nanocrystalline spinel ferrite nanoparticles [M x Co (1-x) Fe 2 O 4 ;(M = Zn,Cu,Mn;x = 0 and 0.5)] like: Cobalt ferrite (CFO), Zinc Cobalt ferrite (ZCFO), Copper Cobalt ferrite (CCFO), and Manganese Cobalt ferrite (MCFO) modified carbon paste electrodes (CPE) were synthesized via sol-gel technique utilizing citric acid and ethylene glycol as a polymerization agent. The synthesized ferrite NPs were used as bi-functional smart biosensor, not only used to determine the drug Anagrelide-HCl (ANDH) in urine and serum samples, but also possesses antimicrobial potential against some pathogenic microbes, founded in the biological samples. The synthesized ferrite NPs were confirmed by XRD, FTIR spectroscopy, SEM, EDX, and elemental mapping images. Antimicrobial activities of ferrite NPs against selected urinary tract infected microbes were investigated. From XRD data and FTIR spectroscopy it is found that the average crystallite size is lies in the range 12.86 to 33.92 ± 1.5 nm, also the bond lengths R A and R B increase from 1.8986 to 1.9145 Å and from 2.0434 to 2.0606 Å respectively and Debye temperature θ D lies in the range of 681.52-708.87 K. Our study describes the improvement of a screen-printed sensor, modified with ferrite NPs materials for rapid, sensitive and cost-effective quantification of ANDH present in the real samples such as blood serum samples, urine and in the pharmaceutical formulations. The results obtained postulate a linear regression between the ANDH charge density of peak current and its concentration in the range from (0.64-8.18 μg/ml) with DL 0.31 μg/ml and QL 0.94 μg/ml. Antimicrobial results indicated that ZCFO NPs were a novel antibacterial agent against Klebsiella pneumoniae (28.0 mm ZOI), and multidrug-resistant bacteria Enterococcus faecalis (27.0 mm ZOI). Additionally, ZCFO NPs were active against Candida albicans (18.0 mm ZOI) seems to be a smart antifungal agent. Therefore, ZCFO NPs can be used as applicant resources for industrial, medical, and biological applications., (Copyright © 2018 Elsevier B.V. All rights reserved.)

In the present study, adsorption and photo-Fenton processes have been compared for the removal of phenol and paracetamol from aqueous solutions in a single and binary systems. NaX nanozeolites and cobalt ferrite nanoparticles were used during adsorption and photo-Fenton processes, respectively. Both nanoparticles were synthesized using microwave heating method. The synthesized nanoparticles were characterized using powder X-ray diffraction (XRD) and scanning electronic microscopy (SEM) analysis. Based on results, more than 99% removing percentages of phenol and paracetamol were obtained during photo-Fenton process at initial concentrations of 10, 20, 50, 100 and 200 mg/L of phenol and paracetamol. Moreover, the complete removing of phenol and paracetamol was only achieved at lower initial concentrations than 10 mg/L for phenol and paracetamol during adsorption process. The results showed a significant dependence of the phenol and paracetamol removing on the initial concentrations of phenol and paracetamol for selection of process. The photo-Fenton process could be considered an alternative method in higher initial concentrations of phenol and paracetamol. However, the adsorption process due to economical issue was preferred for phenol and paracetamol removing at lower initial concentrations. The kinetic data of photo-Fenton and adsorption processes were well described using first-order and pseudo-second-order kinetic models. The results of phenol and paracetamol removing in a binary system confirmed the obtained results of single removing of phenol and paracetamol in selection of process., (Copyright © 2014 Elsevier B.V. All rights reserved.)