1. Lysophosphatidic acid: G-protein signalling and cellular responses.
- Author
-
Moolenaar WH, Kranenburg O, Postma FR, and Zondag GC
- Subjects
- Animals, Humans, Receptors, Cell Surface genetics, Receptors, Cell Surface metabolism, Receptors, Lysophosphatidic Acid, GTP-Binding Proteins metabolism, Lysophospholipids metabolism, Receptors, G-Protein-Coupled, Signal Transduction
- Abstract
Lysophosphatidic acid (LPA) is a serum-borne phospholipid that activates a specific G protein coupled receptor to evoke multiple cellular responses. Recent work has identified two cDNAs encoding putative LPA receptors, various LPA-like agonists that act on distinct receptors, and new pathways that link the receptor(s) to such diverse events as Ras signalling, cytoskeletal remodelling and membrane depolarization.
- Published
- 1997
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