90 results on '"Yamamoto, Tetsuya"'
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2. Contributors
- Author
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Alam, Md Aftab, primary, Alam, Md Noor, additional, Alcaraz-Silva, Jocelyne, additional, Bartsch, Ronny P., additional, Budde, Henning, additional, Carbone, Giuseppe A., additional, Castro-Zaballa, Santiago, additional, Cavelli, Matías, additional, Chung, Debbie P., additional, Ferini-Strambi, Luigi, additional, Galbiati, Andrea, additional, Garcia-Rill, Edgar, additional, García-García, Fabio, additional, Gonzalez, Joaquín, additional, Hollimon, Laronda, additional, Imperatori, Claudio, additional, Ivanov, Plamen Ch., additional, Jean-Louis, Girardin, additional, Kostin, Andrey, additional, Libourel, Paul-Antoine, additional, Machado, Sérgio, additional, Martínez, Armando Jesús, additional, Massullo, Chiara, additional, Mondino, Alejandra, additional, Moore, Jesse, additional, Murillo-Rodríguez, Eric, additional, Olaye, Iredia M., additional, Parrazal, Luis Beltrán, additional, Pascovich, Claudia, additional, Rubido, Nicolás, additional, Salsone, Maria, additional, Sanford, Larry D., additional, Seixas, Azizi A., additional, Streiner, David L., additional, Sweeten, Brook L.W., additional, Torres, Janna Garcia, additional, Torterolo, Pablo, additional, Urbano, Francisco J., additional, Vanini, Giancarlo, additional, Volshteyn, Daniel, additional, Wellman, Laurie L., additional, Williams, Ellita T., additional, Yamamoto, Tetsuya, additional, and Yoshimoto, Junichiro, additional
- Published
- 2022
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3. Electroencephalography power spectra and electroencephalography functional connectivity in sleep
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Massullo, Chiara, primary, Carbone, Giuseppe A., additional, Murillo-Rodríguez, Eric, additional, Machado, Sérgio, additional, Budde, Henning, additional, Yamamoto, Tetsuya, additional, and Imperatori, Claudio, additional
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- 2022
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4. List of Contributors
- Author
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Acosta-Hernández, Mario Eduardo, primary, Almeneessier, Aljohara S., additional, BaHammam, Ahmed S., additional, Bixler, Edward O., additional, Brown, Ritchie E., additional, Budde, Henning, additional, Danisi, Jacqueline, additional, Datta, Subimal, additional, Fernandez-Mendoza, Julio, additional, García-García, Fabio, additional, Garcia-Rill, Edgar, additional, Gupta, Ravi, additional, Machado, Sérgio, additional, Monteiro, Diogo, additional, Monti, Jaime M., additional, Murillo-Rodríguez, Eric, additional, Oliver, Michael D., additional, Pandi-Perumal, Seithikurippu R., additional, Ramírez-Plascencia, Oscar, additional, Rocha, Nuno Barbosa, additional, Roehrs, Timothy, additional, Roth, Thomas, additional, Sahota, Pradeep, additional, Sharma, Rishi, additional, Telles-Correira, Diogo, additional, Thakkar, Mahesh M., additional, Torterolo, Pablo, additional, Vanini, Giancarlo, additional, Veras, André Barciela, additional, Vgontzas, Alexandros N., additional, and Yamamoto, Tetsuya, additional
- Published
- 2019
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5. Sleep Disorders and Genes
- Author
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Murillo-Rodríguez, Eric, primary, Yamamoto, Tetsuya, additional, Veras, André Barciela, additional, Rocha, Nuno Barbosa, additional, Telles-Correira, Diogo, additional, Machado, Sérgio, additional, Monteiro, Diogo, additional, Budde, Henning, additional, and Torterolo, Pablo, additional
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- 2019
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6. Relationship Between Exercise and Beer Ingestion in Regard to Metabolism
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Yamamoto, Tetsuya, primary
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- 2009
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7. List of Contributors
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ABE, FUMIYOSHI, primary, ADDOLORATO, GIOVANNI, additional, ALDRED, PETER, additional, ALLER, R., additional, ALMEIDA, PAULO, additional, ÁLVAREZ, JESÚS-ROMÁN MARTÍNEZ, additional, AMERONGEN, A.V. NIEUW, additional, ANDERSEN, MOGENS L., additional, AOSHIMA, HITOSHI, additional, ARIMOTO-KOBAYASHI, SAKAE, additional, ASFAW, ALEMAYEHU, additional, AUSTIN, ERICA WEINTRAUB, additional, BACK, WERNER, additional, BAEK, SEUNG JOON, additional, BAER-DUBOWSKA, WANDA, additional, BARROS, AQUILES A., additional, BECKER, HANS, additional, BÉNÉDICTE, BAKAN, additional, BERWANGER, STEFANIE, additional, BLEICH, STEFAN, additional, BLUMBERG, JEFFREY B., additional, BOELENS, JERINA, additional, BOHR, GREGOR, additional, BRACKE, MARC, additional, BRAND, H.S., additional, BRUINS, M.L., additional, BUIATTI, STEFANO, additional, CATHARINO, RODRIGO R., additional, CERVERA, M. LUISA, additional, CHEN, CHUNG-YEN, additional, CHEN, QIAO QIAO, additional, CHEN, YUONNES, additional, COMI, GIUSEPPE, additional, CORTACERO-RAMÍREZ, SONIA, additional, DAENEN, L., additional, De COOMAN, L., additional, De LUIS, D.A., additional, De SCHUTTER, D.P., additional, DEINZER, MAX L., additional, DELVAUX, F., additional, DEMMEL, RALF, additional, DERDELINCKX, G., additional, DEY, ESTERA SZWAJCER, additional, DÍAZ-RUBIO, M.E., additional, DICKINSON, J. RICHARD, additional, DIDIER, MARION, additional, DIEL, FRIEDHELM, additional, DIEL, SUSANNE, additional, DILLER, REINHARD A., additional, DLAMINI, ZODWA, additional, DOBROWOLSKA-ZACHWIEJA, AGNIESZKA, additional, DUFOUR, JEAN-PIERRE, additional, EBERLIN, MARCOS N., additional, EFFENBERGER, KATHARINA E., additional, EYRES, GRAHAM, additional, FANTOZZI, PAOLO, additional, FEGREDO, JUSTIN A., additional, FEICK, PETER, additional, FERNÁNDEZ-GUTIÉRREZ, ALBERTO, additional, FERREIRA REQUIMTE, ISABEL M.P.L.V.O., additional, FERRULLI, ANNA, additional, FONTANA, MARTA, additional, FOX, GLEN P., additional, Da CRUZ FRANCISCO, JOSÉ, additional, FRANK, NORBERT, additional, FRANKE, ANDREAS, additional, FREEMAN BRI, GARY, additional, FRIAS, CORAZON, additional, FRÖLICH, SONJA, additional, FUCHS, DIETMAR, additional, GAMIAN, ANDRZEJ, additional, GARCÍA-FALCÓN, S., additional, GARRIGUES, SALVADOR, additional, GASBARRINI, ANTONIO, additional, GASBARRINI, GIOVANNI, additional, GERHÄUSER, CLARISSA, additional, GERLOFF, ANDREAS, additional, GHISELLI, ANDREA, additional, GIL, A.M., additional, GOÑI, I., additional, GORJANOVIĆ, STANISLAVA, additional, de la GUARDIA, MIGUEL, additional, GUERRA, N.P., additional, GUIDO, LUIS F., additional, GUPTA, SANJAY, additional, HELLBORG, LINDA, additional, HENZE, GÜNTER, additional, HERNÁNDEZ-ARTIGA, MARÍA PURIFICACIÓN, additional, HERNÁNDEZ-BORGES, JAVIER, additional, HERWALD, MARIA, additional, HILLEMACHER, THOMAS, additional, HOSSAIN, SHEIKH JULFIKAR, additional, HUGHES, PAUL, additional, HUST, STACEY J.T., additional, HUVAERE, KEVIN, additional, IACOMINO, GIUSEPPE, additional, IGNATOWICZ, EWA, additional, IKEDA, KATSUMI, additional, JANDERA, PAVEL, additional, JENETT-SIEMS, KRISTINA, additional, JUGDAOHSINGH, RAVIN, additional, KAWASAKI, MASATO, additional, KERR, WILLIAM C., additional, KHMELINSKII, IGOR, additional, KISO, YOSHINOBU, additional, KODA, HIROFUMI, additional, KOMAITIS, M., additional, KONDO, KEIJI, additional, KRAJKA-KUZNIAK, VIOLETTA, additional, KRATKY, ROBERTO, additional, KRUISSELBRINK, L. DARREN, additional, LAI, ALAN K.H., additional, LEDOCHOWSKI, M., additional, LEE, SEONG-HO, additional, LEGGIO, LORENZO, additional, LI, HUI-JING, additional, LIRDPRAPAMONGKOL, KRIENGSAK, additional, LITTLE, ALEX G., additional, LÓPEZ-MACÍAS, C., additional, LORET, SUZANNE, additional, LOUKOU, ZACHARENIA, additional, LOZANOV, VALENTIN, additional, LUST, SOFIE, additional, MABIALA-BABELA, JEAN ROBERT, additional, MANZANO, MARISA, additional, MARCONI, OMBRETTA, additional, MARQUES-VIDAL, PEDRO, additional, MARTIN, COLIN R., additional, MARTÍNEZ-CARBALLO, E., additional, MASSAMBA, ALPHONSE, additional, MAYER, HEIDI, additional, MBITA, ZUKILE, additional, Mc KINNEY, ADELE, additional, McCRAE, NIALL, additional, MENZ, GARRY, additional, MEYNELL, RACHEL, additional, MILLA, DOLORES BELLIDO, additional, MILLIGAN, STUART R., additional, MONTANARI, LUIGI, additional, MORALES, FRANCISCO J., additional, MORIWAKI, YUJI, additional, MUKAMAL, KENNETH J., additional, MURPHY, RENÉ J.L., additional, NANADOUM, MAOURA, additional, NARDINI, MIRELLA, additional, NATELLA, FAUSTA, additional, NAVARRO, SIMÓN, additional, NICOLAI, JENNIFER, additional, NOZAWA, HAJIME, additional, OFFNER, FRITZ, additional, PASTRANA-CASTRO, L.M., additional, PAULL, DOUGLAS E., additional, PAVSLER, ANDREA, additional, PEHL, C., additional, PÉREZ-JIMÉNEZ, JARA, additional, PINKLETON, BRUCE E., additional, PISKUR, JURE, additional, POHL, PAWEL, additional, POSSEMIERS, SAM, additional, POURQUIE, JACQUES, additional, POWELL, JONATHAN J., additional, PREEDY, VICTOR R., additional, PROESTOS, C., additional, PROKOP, ARAM, additional, RAINIERI, SANDRA, additional, RAJENDRAM, RAJKUMAR, additional, RAYBURN, BRITTANY B., additional, RAYBURN, WILLIAM F., additional, RIEPL, HERBERT M., additional, RODRIGUES, JOSÉ, additional, RODRIGUEZ-DELGADO, MIGUEL ÁNGEL, additional, ROSE, OLIVER, additional, ROWLAND, NEIL E., additional, RUSSO, GIAN LUIGI, additional, SAIKI, IKUO, additional, SAISON, D., additional, SAKUMA, SHUSO, additional, SAKURAI, HIROAKI, additional, SANDRA, PAT, additional, SAURA-CALIXTO, FULGENCIO, additional, SAWAYA, ALEXANDRA C.H.F., additional, SCACCINI, CRISTINA, additional, SCHENNACH, H., additional, SCHEWE, TANKRED, additional, SCHROECKSNADEL, K., additional, SCHUBERT, CAROLA, additional, SEGURA-CARRETERO, ANTONIO, additional, SEIDL, H., additional, SERRANO, JOSÉ, additional, SHIBAMOTO, TAKAYUKI, additional, SHUKLA, SANJEEV, additional, SIES, HELMUT, additional, SIKORSKA, EWA, additional, SIKORSKI, MAREK, additional, SIMAL-GÁNDARA, J., additional, SINGER, MANFRED V., additional, SOARES, EDUARDO V., additional, SRIRAJASKANTHAN, RAJAVENTHAN, additional, SUZUKI, KOJI, additional, SVASTI, JISNUSON, additional, SZAEFER, HANNA, additional, TEDESCO, IDOLO, additional, TOBE, HIROYASU, additional, TONELLI, DOMENICA, additional, TORRADO-AGRASAR, A., additional, TUBARO, FRANCO, additional, VALLS-BELLÉS, VICTORIA, additional, VANHOECKE, BARBARA, additional, VANHOENACKER, GERD, additional, VEERMAN, E.C.I., additional, VELA, NURIA, additional, VERACHTERT, H., additional, VERSTRAETE, WILLY, additional, VERSTREPEN, K.J., additional, VILLARINO-MARÍN, ANTONIO LUIS, additional, VINSON, JOE A., additional, VOLLMER, GÜNTER, additional, VRIESEKOOP, FRANK, additional, WALKER, CAROLINE, additional, WANNAMETHEE, S. GOYA, additional, WESTENDORF, JOHANNES, additional, WIBETOE, GRETHE, additional, Van De WIELE, TOM, additional, WINKLER, C., additional, WISEMAN, HELEN, additional, WONG, MAX C.Y., additional, WOODMAN, OWEN L., additional, WUNDERLICH, SASCHA, additional, XU, JIN-WEN, additional, YAJIMA, HIROAKI, additional, YAMAMOTO, TETSUYA, additional, YOSHIDA, ARUTO, additional, YOUNG, CHARLES Y.F., additional, ZANOLI, PAOLA, additional, ZAVATTI, MANUELA, additional, ZHAO, FENG, additional, ZIELINSKA-PRZYJEMSKA, MAŁGORZATA, additional, ZIERAU, OLIVER, additional, and ZOTOU, ANASTASIA, additional
- Published
- 2009
- Full Text
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8. Purines in Beer
- Author
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Yamamoto, Tetsuya, primary and Moriwaki, Yuji, additional
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- 2009
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9. Effects of Beer Ingestion on Body Purine Bases
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Moriwaki, Yuji, primary and Yamamoto, Tetsuya, additional
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- 2009
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10. Discourse Management System for Communication Through Spoken Language
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Yamashita, Yoichi, primary, Yamamoto, Tetsuya, additional, and Mizoguchi, Riichiro, additional
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- 1996
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11. Involvement of NF-kB in TGF-β-mediated suppression of IL-4 signaling
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Yamamoto, Tetsuya, Imoto, Seiyu, Sekine, Yuichi, Sugiyama, Kenji, Akimoto, Toshihiko, Muraguchi, Atsushi, and Matsuda, Tadashi
- Subjects
TGF-β ,IL-4 ,499.3 ,NF-κB ,STAT6 - Abstract
Control of immune response requires the coordinated integration of both stimulatory and inhibitory factors. Therefore, the cross-talk of different signaling pathways is critical in providing an integrated cellular response to multiple external signals. Both interleukin-4 (IL-4) and transforming growth factor (TGF-β) are pleiotropic cytokines and play critical roles in controlling immune responses. For example, IL-4 mediates important pro-inflammatory functions in asthma including induction of the IgE isotype switch and expression of vascular cell adhesion molecules. Whereas, TGF-β is secreted from B, T, and dendritic cells as well as macrophages, and negatively regulates their proliferation, differentiation, and activation by other cytokines. In this study, we examined the effect of TGF-β on IL-4 signaling using B cells as well as embryonic kidney cells. TGF-β inhibited IL-4-induced IgG1 production and gene expression of germline ε transcripts in B cells. In embryonic kidney cells, TGF-β signals suppressed IL-4-induced transcription, when we monitored using germline ε promoter DNA. Furthermore, activation of NF-κB resulted in a resistance to TGF-β-mediated suppression of IL-4 signaling. These results indicate that TGF-β-mediated regulation of IL-4 signaling may act by targeting NF-κB signaling.
- Published
- 2004
12. Cell cycle dependency of Porphyrin uptake in glioma cell line
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SHIBATA, Yasushi, Matsumura, Akira, Yoshida, Fumiyo, Yamamoto, Tetsuya, Nakai, Kei, Nose, Tadao, Sakata, Isao, and Nakajima, Susumu
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polycyclic compounds - Abstract
We used a two-color analysis system to assess the porphyrin uptake and DNA content in four established cell lines of glioma employing flow cytometry (FCM). The FCM study revealed porphyrin uptake in all cells, regardless of the phase of the cell cycle they were in. However, those in the G0/G1 phase showed moderate uptake of porphyrin and those in the G2/M phase showed a higher uptake. These results indicated the advantage of using porphyrin as the carrier of tumor targeting agents as a therapeutic strategy for malignant tumors.
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- 1998
13. ATTRACTIVE INTERACTIONS DUE TO RKKY EXCHANGE INTERACTIONS IN HEAVY-ELECTRON SUPERCONDUCTORS
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OHKAWA, Fusayoshi J., primary and YAMAMOTO, Tetsuya, additional
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- 1987
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14. Body talk and body dissatisfaction in Japanese university students: Longitudinal study using the Japanese Body Talk Scale.
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Ito N, Hasegawa A, Adachi M, Oura SI, Yamamoto T, Matsuda Y, and Tomita T
- Abstract
This study evaluated the reliability and validity of the Japanese version of the Body Talk Scale (BTS), designed to measure negative fat talk, negative muscle talk, and positive body talk. The study also explored the longitudinal associations between each body talk category and body dissatisfaction. We conducted two separate studies among university students in Japan. Separate confirmatory factor analyses for female and male data indicated that the initially proposed three-factor model demonstrated an acceptable fit, whereas the bi-factor model provided a better fit. The Japanese BTS showed good construct validity, acceptable to adequate internal consistency, and test-retest reliability within 2 weeks. A four-week longitudinal study involving 386 women and 216 men (mean age = 19.22 and 19.62, respectively) revealed that negative fat talk predicted an increase in the discrepancy between the thin ideal body image and the actual body image among women. In contrast, positive body talk was linked to reduced body dissatisfaction and body image discrepancy in women. There were no such significant associations in men. These findings support the use of the Japanese BTS as a valuable instrument for future research on the intrapersonal and interpersonal effects of various types of body talk., Competing Interests: Declaration of Competing Interest None., (Copyright © 2024. Published by Elsevier Ltd.)
- Published
- 2024
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15. Revision Anterior Cruciate Ligament Reconstruction and Associated Procedures.
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Dadoo S, Benvegnu N, Herman ZJ, Yamamoto T, Hughes JD, and Musahl V
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- Humans, Risk Factors, Treatment Failure, Tenodesis methods, Osteotomy methods, Anterior Cruciate Ligament Reconstruction methods, Reoperation, Anterior Cruciate Ligament Injuries surgery
- Abstract
Failure of anterior cruciate ligament reconstruction (ACLR) is a common yet devastating complication due to inferior clinical outcomes associated with revision ACLR. Identifying the cause and associated risk factors for failure is the most important consideration during preoperative planning. Special attention to tunnel quality, concomitant injuries, and modifiable risk factors will help determine the optimal approach and staging for revision ACLR. Additional procedures including lateral extra-articular tenodesis and osteotomy may be considered for at-risk populations. The purpose of this review is to explore causes of ACLR failure, clinical indications and appropriate patient evaluation, and technical considerations when performing revision ACLR., Competing Interests: Conflict of interest No Disclosure: S. Dadoo, N. Benvegnu, Z.J. Herman, T. Yamamoto, J.D. Hughes. V. Musahl. Education: Smith & Nephew, Arthrex, DePuy Synthes, Conmed. Consulting: Smith & Nephew, Newclip, Ostesys. Royalties: Springer. Shareholder: Ostesys. Board Member: ACL Study Group, AOSSM, ISAKOS, KSSTA (Deputy Editor-in-chief). Codeveloper of iPad app (Serial No. 61/566,761). NIH Grant Support: U01AR076144, W81XWH-16-PRORP-ICTA., (Copyright © 2023 Elsevier Inc. All rights reserved.)
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- 2024
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16. One-Stage Combined Open and Endovascular Treatment Using a Hybrid Operating Room is Safe and Effective for Distal Middle Cerebral Artery Aneurysms.
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Kushi Y, Imamura H, Itazu T, Ozaki S, Niwa A, Shimonaga K, Ikedo T, Hamano E, Yamada K, Ohta T, Satow T, Yamamoto T, Iihara K, and Kataoka H
- Subjects
- Humans, Male, Female, Middle Aged, Retrospective Studies, Aged, Treatment Outcome, Adult, Cerebral Revascularization methods, Embolization, Therapeutic methods, Middle Cerebral Artery surgery, Neurosurgical Procedures methods, Intracranial Aneurysm surgery, Intracranial Aneurysm diagnostic imaging, Endovascular Procedures methods, Operating Rooms
- Abstract
Background: Aneurysms located in the distal middle cerebral artery (DMCA) are relatively rare and lack an established treatment strategy. For DMCA aneurysms, we performed a one-stage combined procedure of endovascular parent artery occlusion (PAO) with coils and superficial temporal artery to middle cerebral artery (STA-MCA) bypass in a hybrid operating room (HOR). The aim of this study was to evaluate the safety and efficacy of this procedure., Methods: Cases of unruptured DMCA aneurysms treated with the one-stage combined PAO and STA-MCA bypass in HOR were retrospectively examined, and patients' and aneurysmal backgrounds, surgical procedures, and treatment outcomes were analyzed., Results: Six patients were included in the study. The average maximum diameter of the aneurysms was 14.4 mm. One aneurysm was located at M2 and five at M3. All aneurysms had a fusiform shape. No cases were associated with infection, trauma, or malignant tumors. In all 6 cases, the combined PAO and STA-MCA bypass was successfully completed. No postoperative hemorrhagic complications occurred. A symptomatic ischemic complication occurred in 1 case whose symptom disappeared in a week. Three months after surgery, complete obliteration of the aneurysm and patency of the bypass was confirmed in all cases., Conclusions: The one-stage combined PAO and STA-MCA bypass in the HOR is safe and effective for DMCA aneurysms, potentially serving as a treatment option for this complex aneurysm., (Copyright © 2024 Elsevier Inc. All rights reserved.)
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- 2024
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17. Use of a stent-retriever for treatment of iatrogenic vasospasm secondary to mechanical thrombectomy.
- Author
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Hori S, Furudate R, Kumagai I, Aoyagi C, Hirota N, and Yamamoto T
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- Humans, Thrombectomy adverse effects, Treatment Outcome, Stents adverse effects, Iatrogenic Disease, Stroke, Ischemic Stroke, Brain Ischemia
- Abstract
The treatment strategy for iatrogenic intracranial vasospasm has not been established. We reported a rare case of stent-retriever use for the treatment of iatrogenic vasospasm after mechanical thrombectomy. The patient presented acute ischemic stroke due to the occlusion of the left middle cerebral artery (MCA). The patient underwent a successfully mechanical thrombectomy, however, severe stenosis was visualized in MCA, which was considered to be an iatrogenic mechanical vasospasm. This vasospasm was successfully treated with the Solitaire stent device, and the patient recovered from ischemic symptoms. A stent-retriever is a safe and effective treatment for iatrogenic vasospasm after mechanical thrombectomy., Competing Interests: Conflict of interest The authors declare that they have no conflict of interest., (Copyright © 2024 Elsevier B.V. All rights reserved.)
- Published
- 2024
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18. Clinical impact of optical coherence tomography findings after drug-coated balloon treatment for patients with acute coronary syndromes.
- Author
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Yamamoto T, Kawamori H, Toba T, Kakizaki S, Nakamura K, Fujimoto D, Sasaki S, Fujii H, Hamana T, Osumi Y, Iwane S, Naniwa S, Sakamoto Y, Matsuhama K, Fukuishi Y, Kozuki A, Shite J, Iwasaki M, Ishida A, Hirata KI, and Otake H
- Subjects
- Humans, Tomography, Optical Coherence methods, Retrospective Studies, Coronary Angiography methods, Treatment Outcome, Coronary Vessels pathology, Acute Coronary Syndrome diagnostic imaging, Acute Coronary Syndrome epidemiology, Acute Coronary Syndrome surgery, Percutaneous Coronary Intervention adverse effects, Percutaneous Coronary Intervention methods, Plaque, Atherosclerotic diagnostic imaging, Plaque, Atherosclerotic surgery, Plaque, Atherosclerotic etiology, Coronary Artery Disease therapy
- Abstract
Background: Drug-coated balloon (DCB) became a potential treatment option for patients with acute coronary syndrome (ACS); however, factors associated with target lesion failure (TLF) remain uncertain., Methods: This retrospective, multicentre, observational study included consecutive ACS patients who underwent optical coherence tomography (OCT)-guided DCB treatment. Patients were divided into two groups according to the occurrence of TLF, a composite of cardiac death, target vessel-related myocardial infarction, and ischemia-driven target lesion revascularisation., Results: We enrolled 127 patients in this study. During the median follow-up period of 562 (IQR: 342-1164) days, 24 patients (18.9%) experienced TLF, and 103 patients (81.1%) did not. The cumulative 3-year incidence of TLF was 22.0%. The cumulative 3-year incidence of TLF was the lowest in patients with plaque erosion (PE) (7.5%), followed by those with rupture (PR) (26.1%) and calcified nodule (CN) (43.5%). Multivariable Cox regression analysis revealed that plaque morphology was independently associated with TLF on pre-PCI (percutaneous coronary intervention) OCT, and residual thrombus burden (TB) was positively associated with TLF on post-PCI OCT. Further stratification by post-PCI TB revealed a comparable incidence of TLF in patients with PR (4.2%) to that of PE if the culprit lesion had a smaller post-PCI TB than the cut-off value (8.4%). TLF incidence was high in patients with CN, regardless of TB size on post-PCI OCT., Conclusions: Plaque morphology was strongly associated with TLF for ACS patients after DCB treatment. Residual TB post-PCI might be a key determinant for TLF, especially in patients with PR., Competing Interests: Declaration of Competing Interest None declared., (Copyright © 2023 Elsevier B.V. All rights reserved.)
- Published
- 2023
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19. De novo progressive dural arteriovenous fistula with putamen hemorrhage associated with long-term Down syndrome: A case report and literature review.
- Author
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Ohgaki F, Suenaga J, Shimizu N, and Yamamoto T
- Abstract
Dural arteriovenous fistula (DAVF) is considered an acquired change in blood flow related to factors such as craniotomy, trauma, and infection. However, several factors related to its development remain unknown. Here, we present a case of a 48-year-old man with Down syndrome and Eisenmenger syndrome. He had a history of craniotomy for multiple brain abscesses, followed by the occurrence of a de novo straight sinus (StS) DAVF within the last 2 years. The patient presented with right putamen hemorrhage due to venous congestion by a StS DAVF. The shunt flow was occluded by transarterial embolization using Onyx. Several studies have reported on DAVF models induced by venous congestion and hypoxemia. In this case, local venous congestion due to craniotomy for multiple brain abscesses was considered as one of the causes of DAVF. Complication of venous thrombosis or chronic hypoxemia due to Eisenmenger syndrome might have led to its progression. Especially in DAVF cases with Down syndrome, concomitant symptoms such as hypoxemia due to congenital heart failure and coagulopathy could worsen the disease state progressively., (© 2023 The Authors. Published by Elsevier Inc. on behalf of University of Washington.)
- Published
- 2023
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20. Gamma Knife Radiosurgery for Metastatic Brain Tumors from Uterine Cervical and Endometrial Carcinomas: Histopathological Analysis of Survival and Local Control. A Japanese Multi-Institutional Cooperative and Retrospective Cohort Study.
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Matsunaga S, Shuto T, Serizawa T, Aoyagi K, Hasegawa T, Kawagishi J, Yomo S, Kenai H, Nakazaki K, Moriki A, Iwai Y, Yamanaka K, and Yamamoto T
- Subjects
- Female, Humans, Treatment Outcome, Retrospective Studies, East Asian People, Radiosurgery methods, Brain Neoplasms surgery, Endometrial Neoplasms surgery, Carcinoma, Squamous Cell surgery
- Abstract
Objective: A retrospective comparative analysis of the outcomes of gamma knife radiosurgery (GKRS) for brain metastases from uterine cervical carcinoma (CC) and endometrial carcinoma (EC), investigated the efficacy and prognostic factors for survival and local tumor control. Histopathological analysis was also performed., Methods: The authors retrospectively reviewed 61 patients with 260 tumors of CC and 73 patients with 302 tumors of EC who had undergone GKRS., Results: The survival times after GKRS had no difference between CC and EC. Uncontrolled primary cancer was significant unfavorable factor. CC resulted in significantly higher neurological death and post-GKRS neurological deterioration. New lesions appeared intracranially after GKRS, with no significant difference between CC and EC. Local tumor control rates at 6, 12, and 24 months after GKRS were 90.0%, 86.6%, and 78.0% for CC and 92.2%, 87.9%, and 86.4% for EC. Primary cancer of CC, more than 7 cm
3 volume, and prescription dose less than 20 Gy were significantly correlated in control failure. Local tumor control rates were significantly lower for squamous cell carcinoma in CC. No significant differences were found between histopathological subtypes of EC., Conclusions: This study established a relationship between the efficacy of GKRS for CC and EC brain metastases and the histopathological. Though, survival time after GKRS has no difference between CC and EC, CC was significantly higher neurogenic death and neurological deterioration after GKRS. Squamous cell carcinoma had a significantly lower rate of local tumor control among all CC, thereby resulting in CC having lower local tumor control than EC., (Copyright © 2022 Elsevier Inc. All rights reserved.)- Published
- 2023
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21. Mechanism of Protein-PDMS Visible Particles Formation in Liquid Vial Monoclonal Antibody Formulation.
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Soeda K, Arai K, Yamamoto T, Ofuji K, Fukuda M, Hashimoto D, and Yamanaka Y
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- Silicone Oils, Drug Packaging, Antibodies, Monoclonal
- Abstract
Visible particles (VPs) formation in liquid monoclonal antibody formulations is a critical quality issue. Formulations that include poloxamer 188 (PX188) as a surfactant are prone to the formation of VPs comprising aggregated complexes of protein and polydimethylsiloxane (PDMS; silicone oil) derived from primary containers. However, the mechanisms through which these VPs form are complicated and remain to be fully elucidated. This study demonstrates for the first time the dominant spot and pathway of protein-PDMS VP formation in a particular liquid vial formulation. Specifically, when a vial sealed with a PDMS-coated stopper is stored in an upright position under conditions whereby the antibody solution has become well-adhered to the stopper and an air phase exists in the vicinity, protein-PDMS aggregates form on the stopper and are then desorbed into the drug solution to be detected as VPs. Here, we evaluated the effects of several factors on VP formation: adhesion of the drug solution to the stopper, storage orientation, silicone coating on the stopper, vial material, and hydrophobicity of PX188. Remarkably, we found that changing any one of the factors could significantly affect VP formation. Our findings are instructive for better understanding the mechanisms of VP formation in vial products and can provide strategies for VP mitigation in biotherapeutics., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2022 American Pharmacists Association. Published by Elsevier Inc. All rights reserved.)
- Published
- 2023
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22. Potential Risk of Jailed Balloon Technique in Left Main Bifurcation Lesions: Sandwiched Jailed Balloon Shaft.
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Yamamoto T, Toba T, Ishii T, and Ishida A
- Subjects
- Humans, Treatment Outcome, Stents, Coronary Angiography, Coronary Artery Disease diagnostic imaging, Coronary Artery Disease therapy, Angioplasty, Balloon, Coronary adverse effects, Angioplasty, Balloon, Coronary methods
- Abstract
Competing Interests: Funding Support and Author Disclosures The authors have reported that they have no relationships relevant to the contents of this paper to disclose.
- Published
- 2023
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23. Duration of antimicrobial therapy after video-assisted thoracoscopic surgery for thoracic empyema and complicated parapneumonic effusion: A single-center study.
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Yukumi S, Ishimaru K, Suzuki H, Abe M, Morimoto M, Senba M, Yamamoto T, Mori Y, Sakao N, and Sano Y
- Subjects
- Humans, Thoracic Surgery, Video-Assisted, Retrospective Studies, Anti-Bacterial Agents therapeutic use, Pleural Effusion, Empyema, Pleural drug therapy, Empyema, Pleural etiology, Empyema, Pleural surgery
- Abstract
Background: There are no evidence-based reports on the proper duration of antimicrobial therapy following video-assisted thoracoscopic surgery debridement (VATS-D) in thoracic empyema (TE) or complicated parapneumonic effusion (PPE). This study aimed to investigate the optimal duration of antimicrobial therapy after VATS-D., Methods: Between January 2011 and December 2019, 33 patients corresponding to American College of Chest Physicians (ACCP) category 3 or 4 undergoing VATS-D were included. The times until the body temperature (BT) was confirmed to be less than 37.5 °C and 37.0 °C, white blood cell count (WBC) less than 10,000/μl, segmented neutrophils (seg) less than 80%, and C-reactive protein (CRP) level less than 25% of the preoperative value were retrospectively analyzed., Results: The median time from the onset of TE/PPE to surgery was 13 days. The median durations of preoperative and postoperative antibiotic use were five and seven days, respectively. Major complications occurred in four cases (three and one cases of respiratory failure and cerebral infarction, respectively). The median postoperative hospital stay was 14 days. Recurrence or progression to chronic empyema was seen in four cases. The median numbers of days until the conditions were met were three days for BT < 37.5 °C, six days for BT < 37.0 °C, four days for WBC<10,000, seven days for seg<80% and seven days for CRP<25%., Conclusions: The proper duration of antimicrobial therapy after VATS-D for TE/PPE is approximately three to seven days. Urgent VATS-D may shorten the total antibiotic usage., Competing Interests: Conflict of Interest The authors have no conflict of interest., (Copyright © 2022 The Japanese Respiratory Society. Published by Elsevier B.V. All rights reserved.)
- Published
- 2023
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24. Impact of post physiological assessment after treatment for de novo coronary lesions using drug-coated balloons.
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Yamamoto T, Ishii T, and Ishida A
- Subjects
- Cardiac Catheterization, Coronary Angiography, Humans, Treatment Outcome, Angioplasty, Balloon, Coronary, Coronary Artery Disease diagnostic imaging, Coronary Artery Disease surgery, Coronary Stenosis therapy, Fractional Flow Reserve, Myocardial, Percutaneous Coronary Intervention
- Abstract
Background: Acute physiological changes after balloon angioplasty are very important because of acute recoil and dissection. However, serial physiological assessments after drug-coated balloons (DCB) have not been investigated., Methods: This prospective observational single-center study evaluated 50 lesions that underwent optical coherence tomography (OCT)-guided percutaneous coronary intervention (PCI) with DCB and a 9-months angiographical and OCT follow-up. Fractional flow reserve (FFR) and instantaneous wave-free ratio (iFR) were measured immediately (FFR0m and, iFR0m) and 15 min (FFR15m and iFR15m) after DCB, and the difference (dif-FFR and, dif-iFR) was calculated. The iFR gradients during lesions treated with DCB were measured. For OCT and quantitative coronary angiography (QCA) data, delta values were calculated., Results: At index PCI, three lesions were needed for bailout stenting. At follow-up, 47 lesions were divided into two groups according to the delta minimal lumen area (MLA) on OCT: late lumen enlargement (LLE) (n = 29) and non-LLE (n = 18). In LLE group, FFR15m and iFR15m were significantly high (0.90 ± 0.03 vs. 0.85 ± 0.07, p < 0.001, 0.97 ± 0.02 vs. 0.92 ± 0.10, p = 0.008, respectively) and %AS on OCT, dif-FFR and dif-iFR were significantly low (38.5% (33.6, 42.3) vs. 45.1% (38.9, 54.6), p = 0.03, -0.001 ± 0.006 vs. 0.036 ± 0.032, p < 0.001, -0.002 ± 0.008 vs. 0.019 ± 0.017, p < 0.001, respectively) compared with non-LLE group. However, there were no significant differences in FFR0m, iFR0m, or any other OCT or QCA data., Conclusions: Post-physiological assessment and a decrease in physiological indices in the first 15 min after PCI are important for treating de novo lesions using the DCB strategy., (Copyright © 2022 Elsevier B.V. All rights reserved.)
- Published
- 2022
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25. Evaluation of a combination protocol of CT-first triage and active telemedicine methods by a selected team tackling COVID-19: An experimental research study.
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Miyake S, Higurashi T, Kato H, Yamaoka Y, Kessoku T, Kato S, Ogawa F, Oi Y, Nakajima A, Yamamoto T, Takeuchi I, Ryo A, and Maeda S
- Subjects
- Humans, Quality of Life, SARS-CoV-2, Tomography, X-Ray Computed, Triage, COVID-19, Telemedicine
- Abstract
Background: Many health care workers around the world tackled with COVID-19, however sadly, the infection of many medical care workers were reported. To reduce the risk of infection, we launched selected team (Team COVID) of non-specialists and brought in active telemedicine method and computed tomography (CT)-first protocol. We describe our actual practice and the health status of medical doctors dealing with COVID-19 patients., Methods: Between April 17, 2020 and May 24, 2020, 10 doctors worked with COVID-19 patients as part of Team COVID. The Team COVID doctors used a CT-first triage protocol for outpatients and telemedicine for inpatients and outpatients. We evaluated paired serum-specific antibodies for SARS-CoV-2 at the initial and end of the study duration and PCR results for SARS-CoV-2 at the end of the study duration. Furthermore, 36-item short-form of the Medical Outcome Study Questionnaire (SF-36) at the beginning and end of the study period were evaluated., Results: Ten doctors worked as Team COVID: seven internal medicine doctors and three surgeons. During the study period, Team COVID treated 165 individuals in the outpatient clinic and isolated hospitalized patients for 315 person-days. There were no positive results of serum-specific antibody testing and PCR testing for SARS-CoV-2 in Team COVID doctors. Furthermore, the SF-36 showed no deterioration in physical and mental QOL status. No in-hospital infection occurred during the study period., Conclusions: The Team COVID fulfilled the treatment using the active telemedicine and CT-first triage protocol without in hospital infection and excess stress. The combination strategy seems acceptable for both the protection and stress relief among the medical staff., (Copyright © 2021 The Author(s). Published by Elsevier Ltd.. All rights reserved.)
- Published
- 2021
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26. Practical Arachnoid Anatomy for the Technical Consideration of Galen Complex Dissection: Cadaveric and Clinical Evaluation.
- Author
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Miyake S, Suenaga J, Nakamura T, Akimoto T, Suzuki R, Ohtake M, Takase H, Tateishi K, Shimizu N, Murata H, Funakoshi K, Sawamura Y, and Yamamoto T
- Subjects
- Aged, Aged, 80 and over, Arachnoid surgery, Cadaver, Female, Humans, Male, Arachnoid anatomy & histology, Brain surgery
- Abstract
Background: The occipital transtentorial approach (OTA) is a very useful but challenging approach to expose the pineal region because the deep-seated arachnoid membranes usually fold and extend over the great vein of Galen (GVG), leading to dense and poor visibility. In addition, the practical aspects of arachnoid anatomy are not well understood. We aimed to develop a safe surgical procedure for the OTA according to the practical aspects of arachnoid anatomy., Methods: The procedure is shown through an illustrative video of surgery and cadaver. Five cadavers were analyzed for their arachnoid structures and the surgical procedures via the OTA, in strict compliance with legal and ethical requirements., Results: All cadavers showed a 2-layered arachnoid structure-one belonging to the occipital lobe, and the other to the cerebellum. According to our cadaveric analysis, the arachnoid attachment of the tentorial apex can be peeled bluntly, with an average distance of 10.2 mm. For our clinical presentation, a pineal tumor with hydrocephalus was detected in a 14-year-old boy. While using the OTA and expanding the deep surgical field, we detached the membrane from the tentorial apex and bluntly peeled it to reveal the deep veins. Finally, gross total removal of the tumor was achieved., Conclusions: A 2-layered arachnoid structure interposes the GVG from above and below the tentorium. The arachnoid membrane below the tentorium can be peeled off bluntly from the GVG to the attachment bundle limited by the penetrating veins. This detachment technique is useful for safe enlargement of the surgical field for the OTA., (Copyright © 2021 Elsevier Inc. All rights reserved.)
- Published
- 2021
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27. Proton beam therapy for children and adolescents and young adults (AYAs): JASTRO and JSPHO Guidelines.
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Mizumoto M, Fuji H, Miyachi M, Soejima T, Yamamoto T, Aibe N, Demizu Y, Iwata H, Hashimoto T, Motegi A, Kawamura A, Terashima K, Fukushima T, Nakao T, Takada A, Sumi M, Oshima J, Moriwaki K, Nozaki M, Ishida Y, Kosaka Y, Ae K, Hosono A, Harada H, Ogo E, Akimoto T, Saito T, Fukushima H, Suzuki R, Takahashi M, Matsuo T, Matsumura A, Masaki H, Hosoi H, Shigematsu N, and Sakurai H
- Subjects
- Adolescent, Adult, Child, Humans, Neoplasms pathology, Societies, Medical, Young Adult, Neoplasms radiotherapy, Practice Guidelines as Topic standards, Proton Therapy methods
- Abstract
Children and adolescents and young adults (AYAs) with cancer are often treated with a multidisciplinary approach. This includes use of radiotherapy, which is important for local control, but may also cause adverse events in the long term, including second cancer. The risks for limited growth and development, endocrine dysfunction, reduced fertility and second cancer in children and AYAs are reduced by proton beam therapy (PBT), which has a dose distribution that decreases irradiation of normal organs while still targeting the tumor. To define the outcomes and characteristics of PBT in cancer treatment in pediatric and AYA patients, this document was developed by the Japanese Society for Radiation Oncology (JASTRO) and the Japanese Society of Pediatric Hematology/Oncology (JSPHO)., (Copyright © 2021 The Author(s). Published by Elsevier Ltd.. All rights reserved.)
- Published
- 2021
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28. Influence of selected plane on the evaluation of tibial tunnel locations using a three-dimensional bone model in double-bundle anterior cruciate ligament reconstruction.
- Author
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Yamamoto T, Nagai K, Araki D, Miyaji N, Nakanishi Y, Hoshino Y, Kanzaki N, Matsumoto T, Niikura T, Kuroda R, and Matsushita T
- Subjects
- Adult, Female, Humans, Imaging, Three-Dimensional, Male, Retrospective Studies, Tomography, X-Ray Computed, Anterior Cruciate Ligament Reconstruction methods, Computer Simulation, Tibia diagnostic imaging, Tibia surgery
- Abstract
Background: The purpose of this study was to investigate the influence of a selected plane on the evaluation of tibial tunnel locations following anterior cruciate ligament reconstruction (ACLR) between two planes: the plane parallel to the tibial plateau (Plane A) and the plane perpendicular to the proximal tibial shaft axis (Plane B)., Methods: Thirty-four patients who underwent double-bundle ACLR were included. Three-dimensional model of tibia was created using computed tomography images 2 weeks postoperatively, and tibial tunnels of the anteromedial bundle (AMB) and posterolateral bundle (PLB) were extracted. To evaluate tibial tunnel locations, two planes (Planes A and B) were created. The locations of the tibial tunnel apertures of each bundle were evaluated using a grid method and compared between Planes A and B. The difference in coronal alignment between Planes A and B were also assessed., Results: The AMB and PLB tunnel apertures in Plane A were significantly more laterally located than in Plane B (mean difference; AMB, 1.5%; PLB, 1.7%, P < 0.01). There were no significant differences in the anteroposterior direction between the planes. Coronal alignment difference between the planes was 16.8 ± 2.2°; Plane B was more valgus than Plane A., Conclusion: Although tibial tunnel locations were not significantly influenced by the selected planes in the AP direction, subtle but statistically significant differences were found in the ML direction between the Planes A and B in double-bundle anterior cruciate ligament reconstruction. The findings suggest that both Planes A and B can be used in the assessment of tibial tunnel locations after anterior cruciate ligament reconstruction., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2021 Elsevier B.V. All rights reserved.)
- Published
- 2021
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29. Uric acid inhibits HMGB1-TLR4-NF-κB signaling to alleviate oxygen-glucose deprivation/reoxygenation injury of microglia.
- Author
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Wang Q, Zhao H, Gao Y, Lu J, Xie, Yu W, He F, Liu W, Hisatome I, Yamamoto T, Wang W, and Cheng J
- Subjects
- Animals, Cell Line, Cell Survival, Disease Models, Animal, HMGB1 Protein metabolism, Inflammation drug therapy, Inflammation Mediators metabolism, Ischemic Stroke pathology, Male, Mice, Mice, Inbred C57BL, Microglia metabolism, Microglia pathology, NF-kappa B metabolism, Oxygen metabolism, Probenecid pharmacology, Signal Transduction drug effects, Toll-Like Receptor 4 metabolism, Uric Acid metabolism, Cell Hypoxia drug effects, Glucose metabolism, Ischemic Stroke drug therapy, Ischemic Stroke metabolism, Microglia drug effects, Uric Acid pharmacology, Uric Acid therapeutic use
- Abstract
Mounting evidence has implicated inflammation in ischemia-reperfusion injury following acute ischemic stroke (AIS). Microglia remain the primary initiator and participant of brain inflammation. Emerging evidence has indicated that uric acid has promise for the treatment of AIS, but its explicit mechanisms remain elusive. Here, we observed that uric acid reduced the severity of cerebral infarction and attenuated the activation of microglia in the cerebral cortex in a mouse middle cerebral-artery occlusion/reperfusion model. Thus, we speculated that uric acid may play a role by directly interfering with the inflammatory response of microglia. First, we investigated whether the HMGB1-TLR4-NF-κB signaling plays a role in oxygen glucose deprivation and reperfusion (OGD/R) injury of BV2 cells. Inhibition of the signaling significantly reduced the release of the proinflammatory cytokines tumor necrosis factor α (TNF-α), interleukin 1β (IL1β), and IL6 caused by OGD/R in BV2 cells. Second, uric acid weakened the decreased cell viability and lactate dehydrogenase release induced by OGD/R in BV2 cells. Finally, uric acid reduced the release of the proinflammatory cytokines TNF-α, IL1β, and IL6 caused by OGD/R in BV2 cells by dampening HMGB1-TLR4-NF-κB signaling, which was reversed by probenecid treatment, an inhibitor of the uric acid channel. Hence, uric acid halted the release of inflammatory factors and the decreased cell viability induced by ODG/R via inhibiting the microglia HMGB1-TLR4-NF-κB signaling, thereby alleviating the damage to microglia. This may be part of the molecular mechanisms by which uric acid protects mice against the brain damage of middle cerebral-artery occlusion/reperfusion., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2021 Elsevier Inc. All rights reserved.)
- Published
- 2021
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30. Anoikis resistance conferred by tenascin-C-derived peptide TNIIIA2 and its disruption by integrin inactivation.
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Fujita M, Sasada M, Iyoda T, Nagai R, Kudo C, Yamamoto T, Osada S, Kodama H, and Fukai F
- Subjects
- Cell Adhesion drug effects, Cell Line, Tumor, Cell Survival drug effects, Fibronectins chemistry, Humans, Anoikis, Integrin beta1 metabolism, Peptides pharmacology, Tenascin chemistry
- Abstract
Glioblastoma multiforme (GBM), the most common brain tumor in adults, has an extremely poor prognosis, which is attributed to the aggressive properties of GBM cells, such as dysregulated proliferation and disseminative migration. We recently found that peptide TNIIIA2, derived from tenascin-C (TNC), which is highly expressed in GBM, contributes to the acquisition of these aggressive properties through β1-integrin activation. In general, cancer cells often acquire an additional malignant property that confers resistance to apoptosis due to loss of adhesion to the extracellular matrix, termed anoikis resistance. Our present results show that regulation of β1-integrin activation also plays a key role in both the development and loss of anoikis resistance in GBM cells. Despite being derived from a GBM with an extremely poor prognosis, the human GBM cell line T98G was susceptible to anoikis but became anoikis resistant via treatment with peptide TNIIIA2, which is able to activate β1-integrin. The TNIIIA2-conferred anoikis resistance of T98G cells was disrupted by further addition of peptide FNIII14, which has the ability to inactivate β1-integrin. Moreover, anchorage-independent survival of GBM cells in suspension culture was abrogated by peptide FNIII14, but not by RGD and CS-1 peptides, which are antagonistic for integrins α5β1, αvβ3, and α4β1. These results suggest that GBM cells develop anoikis resistance through activation of β1-integrin by TNC-derived peptide TNIIIA2, which is abundantly released into the tumor microenvironment of GBM. Inactivation of β1-integrin may provide a promising strategy to overcome the apoptosis resistance of cancer cells, including GBM., (Copyright © 2020 Elsevier Inc. All rights reserved.)
- Published
- 2021
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31. Possible mechanism of late lumen enlargement after treatment for de novo coronary lesions with drug-coated balloon.
- Author
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Yamamoto T, Sawada T, Uzu K, Takaya T, Kawai H, and Yasaka Y
- Subjects
- Coronary Angiography, Coronary Vessels diagnostic imaging, Humans, Treatment Outcome, Ultrasonography, Interventional, Angioplasty, Balloon, Coronary adverse effects, Coronary Artery Disease diagnostic imaging, Coronary Artery Disease therapy, Pharmaceutical Preparations
- Abstract
Background: Drug-coated balloon (DCB) treatment for de novo coronary artery disease has demonstrated late lumen enlargement (LLE) in mid-term follow-up and it was considered as clinical benefit; however, its mechanism and the predictive factor remains unclear., Methods: This study enrolled 46 consecutive patients (54 lesions) treated with DCB, using intravascular ultrasound (IVUS) at the index procedure and at the 9-month follow-up. We measured IVUS parameters at 1-mm intervals and calculated the mean volume of the external elastic membrane (EEM), lumen, and plaque. We calculated the dissection index (DI) defined as summation of the following points, 2: dissection over EEM, 1: intra-EEM dissection, 0: no dissection at every 1-mm interval, and divided by lesion length., Results: IVUS showed that there was no flow limiting dissection just after DCB treatment, the mean EEM and lumen volume (LV) had significantly increased while mean plaque volume had significantly decreased at 9 months, and 74.1% lesions exhibited LLE. We divided the patients into three groups according to delta mean LV. Mean EEM volume significantly increased and mean plaque volume significantly decreased in the larger and smaller LLE groups, but not in the non-LLE group. The DI was higher in a descending order in the three groups. The multiple regression analysis demonstrated that the DI was the strongest predictor of the change in mean LV., Conclusions: LLE after DCB treatment may be caused by vessel enlargement and plaque regression. The non-flow limiting larger dissection just after DCB treatment may strongly associate with the intending LLE., Competing Interests: Declaration of Competing Interest The authors declare no conflicts of interest., (Copyright © 2020 The Author(s). Published by Elsevier B.V. All rights reserved.)
- Published
- 2020
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32. Acute Management of Gamma Knife Radiosurgery for Asymptomatic Obstructive Hydrocephalus Associated with Posterior Fossa Metastases.
- Author
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Matsunaga S, Shuto T, Kobayashi N, Murata H, and Yamamoto T
- Subjects
- Adult, Aged, Aged, 80 and over, Cranial Fossa, Posterior diagnostic imaging, Female, Gastrointestinal Neoplasms mortality, Gastrointestinal Neoplasms pathology, Humans, Hydrocephalus diagnostic imaging, Incidence, Magnetic Resonance Imaging, Male, Middle Aged, Neurosurgical Procedures adverse effects, Postoperative Complications epidemiology, Postoperative Complications mortality, Radiosurgery adverse effects, Retrospective Studies, Skull Base Neoplasms diagnostic imaging, Treatment Outcome, Cranial Fossa, Posterior surgery, Hydrocephalus etiology, Hydrocephalus surgery, Neurosurgical Procedures methods, Radiosurgery methods, Skull Base Neoplasms complications, Skull Base Neoplasms secondary
- Abstract
Objective: We retrospectively assessed the effectiveness and safety of Gamma Knife radiosurgery (GKRS) for asymptomatic obstructive hydrocephalus associated with posterior fossa metastases, which was known empirically but not well discussed., Methods: We reviewed the medical records of 27 patients who underwent GKRS for asymptomatic obstructive hydrocephalus related to posterior fossa metastases., Results: Cumulative control rates of hydrocephalus were 11.1%, 51.9%, 70.4%, and 74.6% at 1, 2, 3, and 6 months after GKRS. Primary gastrointestinal tract cancer (P = 0.001) was significantly correlated with unfavorable management. Evans ratio at GKRS (median 0.31) improved significantly compared with that at 1-3 months after GKRS (median 0.26) (P < 0.0001) and maintained at 6 to 12 months. Cumulative local tumor control rates were 91.7%, 70.8%, and 64.4% at 3, 6, and 12 months after GKRS. Primary gastrointestinal tract cancer (P = 0.018) and no conventional systemic agents (P = 0.027) were significantly correlated with unfavorable control. Cumulative incidence rates of adverse radiation effects were 0.0%, 16.7%, and 24.2% at 6, 9, and 12 months after GKRS. Primary gastrointestinal tract cancer (P < 0.0001) and single and 2- or 3-fraction GKRS (P < 0.0001) were significantly correlated with unfavorable outcomes. All but 1 patient avoided surgical procedure for hydrocephalus after GKRS., Conclusions: The present findings suggest that GKRS is an effective and safe treatment for asymptomatic obstructive hydrocephalus caused by posterior fossa metastases, and all but 1 could avoid invasive surgical procedures for hydrocephalus. Posterior fossa metastases from gastrointestinal tract cancer resulted in unsatisfactory outcomes for control of hydrocephalus, tumor progression, and adverse radiation effects., (Copyright © 2020. Published by Elsevier Inc.)
- Published
- 2020
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33. Incision Edge "Lifting Method" in Cerebral Bypass Surgery: A Novel Optional Technique for Narrow or Thin Recipient Arteries.
- Author
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Miyazaki R, Murata H, Sato M, Ueno R, Ikegaya N, Matsumoto S, Abe H, Nagao K, Shimizu N, Tateishi K, Suenaga J, and Yamamoto T
- Subjects
- Adult, Anastomosis, Surgical methods, Female, Humans, Male, Middle Aged, Cerebral Revascularization methods, Intracranial Aneurysm surgery, Intracranial Arteriosclerosis surgery, Moyamoya Disease surgery
- Abstract
Background: Cerebral bypass surgery, such as the superficial temporal artery-middle cerebral artery bypass, is one of the essential procedures for cerebral revascularization. However, very narrow or thin blood vessels will increase the risk of anastomotic problems, such as occurs in Moyamoya disease. For such vessels, we have devised a "lifting method" in the recipient arteriotomy. In the present study, we have introduced this novel optional technique and evaluated its effects., Methods: The lifting method is a procedure of lifting the incision edge of a linear incision on the recipient vessel to widen the ostium. We attempted the lifting method in 23 consecutive patients (41 arteries) and, as a historical control, compared the results with those from the conventional method in 25 consecutive patients (37 arteries) for the previous 3 years. We compared patient age, years of surgical experience, recipient vessel diameter, anastomotic events, and final patency. As a subanalysis, the same evaluations were performed separately for patients with Moyamoya disease. Furthermore, the time required for the lifting procedure was measured retrospectively., Results: The incidence of anastomotic events with the conventional method was 13.5% overall and 19% in those with Moyamoya disease. No adverse events occurred with the lifting method (P < 0.05). No statistically significant differences were found for the other factors, including final patency between the 2 groups. The time required for the lifting procedure averaged 1 minute, 15 seconds., Conclusions: Use of the lifting method widens and secures the ostium in a recipient vessel and greatly facilitates operability. We have found it to be a foolproof method enabling safe and reliable anastomosis even with narrow or thin vessels., (Copyright © 2020 Elsevier Inc. All rights reserved.)
- Published
- 2020
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34. The Visualization Methods of Occluded Dural Sinus for Safe Transvenous Embolization of Dural AVFs.
- Author
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Hosoo H, Tsuruta W, Nakai Y, Shiigai M, Sato M, Ito Y, Takigawa T, Marushima A, Ishikawa E, Yamamoto T, Matsumaru Y, and Matsumura A
- Subjects
- Aged, Catheters, Cavernous Sinus surgery, Central Nervous System Vascular Malformations therapy, Cranial Sinuses diagnostic imaging, Female, Humans, Magnetic Resonance Imaging methods, Male, Middle Aged, Cavernous Sinus diagnostic imaging, Central Nervous System Vascular Malformations diagnostic imaging, Cranial Sinuses surgery, Embolization, Therapeutic methods
- Abstract
Background: Transvenous embolization (TVE) via occluded sinus is one option for the treatment of dural arteriovenous fistulas. Understanding of the anatomical characteristics of the occluded sinus is difficult. It is often hard to reach the shunt point because of some risk of vessel perforation., Methods: We assessed usefulness of T1 Volumetric Isotropic TSE Acquisition (VISTA) Black Blood (BB) and 3D-T1 Fast Field Echo (FFE) for the evaluation and visualization of an occluded sinus. Evaluation of T1 VISTA BB and 3D-T1 FFE was performed preoperatively. TVE was performed via the occluded sinus while referring to the visualized reconstruction image., Results: Fourteen cases of TVE were performed between 2009 and 2015. The entire occluded sinus, including both thrombus and blood flow, was seen as the high-intensity region on 3D FFE T1 gadlinium (Gd). On the other hand, thrombus was seen as the iso- or high-intensity region and blood flow as the low-intensity region on T1 VISTA BB. The maximum intensity projection reconstruction image of 3D FFE T1Gd could visualize the whole occluded sinus and was useful for microcatheter maneuver. Total shunt obliteration was achieved in 13 cases (92.8%) except for one., Conclusions: Magnetic resonance imaging evaluation of the occluded sinus using both T1 VISTA BB and 3D FFE T1Gd gives us valuable information of the occluded sinus regarding the development and the course of the occluded sinus, the length of the thrombotic occlusion, and leads to safer catheter maneuvers in TVE., (Copyright © 2019. Published by Elsevier Inc.)
- Published
- 2019
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35. Delayed C5 Palsy After Anterior Cervical Decompression Surgery: Preoperative Foraminal Stenosis and Postoperative Spinal Cord Shift Increase the Risk of Palsy.
- Author
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Takase H, Murata H, Sato M, Tanaka T, Miyazaki R, Yoshizumi T, Tateishi K, Kawahara N, and Yamamoto T
- Subjects
- Adult, Aged, Aged, 80 and over, Cervical Vertebrae diagnostic imaging, Constriction, Pathologic diagnostic imaging, Constriction, Pathologic epidemiology, Female, Humans, Male, Middle Aged, Paralysis diagnostic imaging, Paralysis epidemiology, Risk Factors, Spinal Cord Diseases diagnostic imaging, Spinal Cord Diseases epidemiology, Spinal Diseases diagnostic imaging, Spinal Diseases epidemiology, Cervical Vertebrae surgery, Decompression, Surgical, Paralysis etiology, Postoperative Complications diagnostic imaging, Postoperative Complications epidemiology, Spinal Cord Diseases etiology, Spinal Diseases surgery
- Abstract
Objective: Postoperative C5 palsy is a well-known complication after cervical decompression with either a posterior or an anterior approach. Its cause has been discussed more regarding the posterior approach. The main hypothesis is that postoperative spinal cord shift causes root traction and palsy. However, the pathogenesis in anterior cases has not been fully described. Therefore, the purpose of this study was to clarify the risk factors for C5 palsy in the anterior approach through our C5 palsy cases., Methods: A total of 149 surgical patients with an anterior cervical lesion were treated by a specific spinal surgeon under consistent same treatment strategy. Of these patients, 88 who satisfied the evaluation criteria were enrolled. Postoperative C5 palsy was defined as postoperative weakness of the deltoid with or without weakness of the biceps brachii. Risk factors of C5 palsy were extracted from clinical backgrounds, surgical approaches, and radiologic findings from patients with palsy., Results: Four sides of 3 individuals (4.6%) who underwent multiple corpectomy developed C5 palsy. All paralyses became evident several days after the surgery and recovered. Older age, multiple corpectomy, postoperative spinal cord shift, and foraminal stenosis of C4-5 and C5-6 were statistically extracted as causative factor of C5 palsy. In the patients with palsy, distortion of the anterior nerve root as a result of a residual vertebral spur was observed with anterior spinal cord shift after anterior corpectomy., Conclusions: Multiple corpectomy for patients with longer anterior lesions and locally developed kyphosis is related to a larger postoperative cord shift, which can cause the occurrence of C5 palsy. Moreover, C4-5 or C5-6 foraminal stenosis can accelerate tethering of the C5 or C6 nerve root. Older patients undergoing multiple corpectomy are susceptible to these risks of palsy. Appropriate patient selection and sufficient additional foraminotomy should be considered for extensive anterior lesions and locally developed kyphosis to avoid postoperative C5 palsy., (Copyright © 2018 Elsevier Inc. All rights reserved.)
- Published
- 2018
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36. Succinate Dehydrogenase B Subunit-Negative Jugular Foramen Paraganglioma Manifesting Malignant Progression with Pseudohypoxia-Related Atypical Uptake of [ 18 F]-Fluoro-2-Deoxy-d-Glucose: A Case Report.
- Author
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Ohtake M, Tateishi K, Murata H, Nagashima Y, Yamanaka S, and Yamamoto T
- Subjects
- Biomarkers, Tumor biosynthesis, Diagnosis, Differential, Fatal Outcome, Female, Head and Neck Neoplasms metabolism, Head and Neck Neoplasms surgery, Humans, Hypoxia, Brain metabolism, Hypoxia, Brain surgery, Middle Aged, Paraganglioma metabolism, Paraganglioma surgery, Protein Subunits biosynthesis, Skull Base diagnostic imaging, Skull Base surgery, Disease Progression, Fluorodeoxyglucose F18 metabolism, Head and Neck Neoplasms diagnostic imaging, Hypoxia, Brain diagnostic imaging, Paraganglioma diagnostic imaging, Succinate Dehydrogenase biosynthesis
- Abstract
Background: Paragangliomas are generally benign, slow-growing tumors. However, approximately 10%-20% are malignant, characterized by distant metastasis. Recently, a germ line mutation in succinate dehydrogenase B subunit (SDHB) has been shown to be associated with malignant behavior in paraganglioma. Here we present a case of SDHB-negative malignant paraganglioma of the jugular foramen with a pseudohypoxic microenvironment and unique imaging features on [
18 F]-fluoro-2-deoxy-d-glucose positron emission tomography ([18 F]-FDG PET), and discuss the significance of SDHB immunohistochemistry and the potential of [18 F]-FDG PET for clinical management., Case Description: A 55-year-old woman was diagnosed with jugular foramen paraganglioma. Initial surgical resection was performed; however, follow-up [18 F]-FDG PET indicated multiple uptake regions throughout the body. Biopsies for multiple recurrent lesions revealed consistent pathological features, suggesting distant metastasis. Immunohistochemical analysis revealed a lack of SDHB immunostaining in all specimens. Pseudohypoxic markers, including hypoxia-inducible factor-1α and downstream glycolysis enzymes, were strongly expressed. [18 F]-FDG PET demonstrated increased uptake in the lesions, and the patient died 3 years after initial metastasis., Conclusion: In patients with head and neck paraganglioma without SDHB expression, close follow-up should be considered because of the risk for metastasis. In such cases, [18 F]-FDG PET might be useful for detecting metastasis due to atypical accumulation from pseudohypoxia-induced glycolysis., (Copyright © 2018 Elsevier Inc. All rights reserved.)- Published
- 2018
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37. MyD88 Mutation in Elderly Predicts Poor Prognosis in Primary Central Nervous System Lymphoma: Multi-Institutional Analysis.
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Takano S, Hattori K, Ishikawa E, Narita Y, Iwadate Y, Yamaguchi F, Nagane M, Akimoto J, Oka H, Tanaka S, Sakata M, Matsuda M, Yamamoto T, Chiba S, and Matsumura A
- Subjects
- Adult, Aged, Aged, 80 and over, Brain Neoplasms mortality, Disease-Free Survival, Female, Humans, Kaplan-Meier Estimate, Lymphoma, Large B-Cell, Diffuse mortality, Male, Middle Aged, Mutation, Prognosis, Proportional Hazards Models, Brain Neoplasms genetics, Lymphoma, Large B-Cell, Diffuse genetics, Myeloid Differentiation Factor 88 genetics
- Abstract
Background: Recent genetic analysis of primary central nervous system lymphoma (PCNSL) showed that the MyD88 L265P mutation, which is related to NF-κB signaling, was a genetic hallmark for PCNSL; thus it could serve as a genetic marker for diagnosis and a potential target for molecular therapy. However, the role of the MyD88 mutation in PCNSL has not been defined. In this study, we investigated the role of the MyD88 mutation and clinical features of PCNSL-treated patients at several institutions to determine its significance as a prognostic factor., Methods: Forty-one PCNSL (diffuse large B-cell type) patients from 8 institutions were included in this study. Their median age was 68 years; median follow-up was 26.7 months; median overall survival was 26.7 months; and their 1-year, 3-year, and 5-year survival rates were 75.6%, 58.5%, and 43.9%, respectively. Deoxyribonucleic acid was extracted from frozen tissue, and the MyD88 L265P mutation was evaluated by polymerase chain reaction and direct sequencing., Results: The MyD88 L265P mutation was found in 61.0% (25/41) of cases. Kaplan-Meier analysis revealed that neither MyD88 L265P mutation nor age >65 years alone significantly predicted overall survival relative to MyD88 wild type and age <65. The MyD88 L265P mutation was predominantly present in patients aged >65 years. Among age >65 patients, the MyD88 L265P mutation portended a worse overall survival compared with the MyD88 wild type (11.5 vs. 56.2 months P < 0.04)., Conclusion: The MyD88 L265P mutation predicted a poor prognosis in elderly PCNSL patients. A new tailor-made treatment strategy might be needed for these patients., (Copyright © 2017. Published by Elsevier Inc.)
- Published
- 2018
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38. Corrigendum to "The optimization of fluorescence imaging of brain tumor tissue differentiated from brain edema-in vivo kinetic study of 5-aminolevulinic acid and talaporfin sodium" [Photodiagn. Photodyn. Ther. 6 (2009), 19-27].
- Author
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Tsurubuchi T, Zaboronok A, Yamamoto T, Nakai K, Yoshida F, Shirakawa M, Matsuda M, and Matsumura A
- Published
- 2017
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39. A brain phantom for motion-corrected PROPELLER showing image contrast and construction similar to those of in vivo MRI.
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Saotome K, Matsushita A, Matsumoto K, Kato Y, Nakai K, Murata K, Yamamoto T, Sankai Y, and Matsumura A
- Subjects
- Adult, Algorithms, Artifacts, Female, Humans, Motion, Reference Values, Brain anatomy & histology, Brain diagnostic imaging, Image Processing, Computer-Assisted methods, Magnetic Resonance Imaging methods, Phantoms, Imaging
- Abstract
Purpose: A fast spin-echo sequence based on the Periodically Rotated Overlapping Parallel Lines with Enhanced Reconstruction (PROPELLER) technique is a magnetic resonance (MR) imaging data acquisition and reconstruction method for correcting motion during scans. Previous studies attempted to verify the in vivo capabilities of motion-corrected PROPELLER in real clinical situations. However, such experiments are limited by repeated, stray head motion by research participants during the prescribed and precise head motion protocol of a PROPELLER acquisition. Therefore, our purpose was to develop a brain phantom set for motion-corrected PROPELLER., Materials and Methods: The profile curves of the signal intensities on the in vivo T
2 -weighted image (T2 WI) and 3-D rapid prototyping technology were used to produce the phantom. In addition, we used a homemade driver system to achieve in-plane motion at the intended timing. We calculated the Pearson's correlation coefficient (R2 ) between the signal intensities of the in vivo T2 WI and the phantom T2 WI and clarified the rotation precision of the driver system. In addition, we used the phantom set to perform initial experiments to show the rotational angle and frequency dependences of PROPELLER., Results: The in vivo and phantom T2 WIs were visually congruent, with a significant correlation (R2 ) of 0.955 (p<.001). The rotational precision of the driver system was within 1 degree of tolerance. The experiment on the rotational angle dependency showed image discrepancies between the rotational angles. The experiment on the rotational frequency dependency showed that the reconstructed images became increasingly blurred by the corruption of the blades as the number of motions increased., Conclusions: In this study, we developed a phantom that showed image contrasts and construction similar to the in vivo T2 WI. In addition, our homemade driver system achieved precise in-plane motion at the intended timing. Our proposed phantom set could perform systematic experiments with a real clinical MR image, which to date has not been possible in in vivo studies. Further investigation should focus on the improvement of the motion-correction algorithm in PROPELLER using our phantom set for what would traditionally be considered problematic patients (children, emergency patients, elderly, those with dementia, and so on)., (Copyright © 2016 Elsevier Inc. All rights reserved.)- Published
- 2017
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40. Remote detected Low-Field MRI using an optically pumped atomic magnetometer combined with a liquid cooled pre-polarization coil.
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Hilschenz I, Ito Y, Natsukawa H, Oida T, Yamamoto T, and Kobayashi T
- Abstract
Superconducting quantum interference devices are widely used in basic and clinical biomagnetic measurements such as low-field magnetic resonance imaging and magnetoencephalography primarily because they exhibit high sensitivity at low frequencies and have a wide bandwidth. The main disadvantage of these devices is that they require cryogenic coolants, which are rather expensive and not easily available. Meanwhile, with the advances in laser technology in the past few years, optically pumped atomic magnetometers (OPAMs) have been shown to be a good alternative as they can have adequate noise levels and are several millimeters in size, which makes them significantly easier to use. In this study, we used an OPAM module operating at a Larmor frequency of 5kHz to acquire NMR and MRI signals. This study presents these initial results as well as our initial attempts at imaging using this OPAM module. In addition, we have designed a liquid-cooled pre-polarizing coil that reduces the measurement time significantly., (Copyright © 2016 Elsevier Inc. All rights reserved.)
- Published
- 2017
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41. Optical coherence tomography-based diagnosis in a patient with ST-elevation myocardial infarction and no obstructive coronary arteries.
- Author
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Takahashi T, Okayama H, Matsuda K, Yamamoto T, Hosokawa S, Kosaki T, Kawamura G, Shigematsu T, Kinoshita M, Kawada Y, Hiasa G, Yamada T, and Kazatani Y
- Subjects
- Clinical Decision-Making, Coronary Angiography methods, Diagnosis, Differential, Electrocardiography methods, Humans, Magnetic Resonance Imaging, Cine methods, Male, Middle Aged, Patient Care Management methods, Platelet Aggregation Inhibitors administration & dosage, Troponin I analysis, Aspirin administration & dosage, Coronary Vessels diagnostic imaging, Hydroxymethylglutaryl-CoA Reductase Inhibitors administration & dosage, ST Elevation Myocardial Infarction diagnosis, ST Elevation Myocardial Infarction drug therapy, ST Elevation Myocardial Infarction physiopathology, Tomography, Optical Coherence methods
- Published
- 2016
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42. Hemifacial Spasm Associated with Contralateral Foramen Magnum Meningioma.
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Matsuda M, Akutsu H, Yamamoto T, Ishikawa E, and Matsumura A
- Subjects
- Aged, 80 and over, Female, Humans, Magnetic Resonance Imaging, Foramen Magnum pathology, Functional Laterality physiology, Hemifacial Spasm complications, Meningeal Neoplasms complications, Meningioma complications
- Abstract
Background: Hemifacial spasm (HFS) caused by a contralateral tumor is extremely rare, and all previously reported cases involved tumors at the cerebellopontine angle. We provide the first report to our knowledge of HFS caused by a contralateral foramen magnum meningioma, which improved after tumor removal without microvascular decompression., Case Description: An 80-year-old woman presented with HFS caused by a contralateral foramen magnum meningioma. She had a 3-year history of gradual worsening of right-sided HFS. Magnetic resonance imaging showed a homogeneous gadolinium-enhancing tumor occupying the left ventrolateral portion of the foramen magnum. The loop of the right anterior inferior cerebellar artery extended into the right pontomedullary junction, compressing the root exit zone (REZ) of the right facial nerve. After tumor removal, with no attempt of confirmation of vascular compression of the right facial nerve REZ, facial spasm gradually decreased and eventually almost disappeared. Postoperative magnetic resonance imaging revealed that the loop of anterior inferior cerebellar artery had shifted away from the right facial nerve REZ. Dorsal shift of the anterior inferior cerebellar artery loop toward the facial nerve REZ along with dorsal shift of the vertebral and basilar arteries secondary to the huge contralateral mass located in the ventrolateral portion of the foramen magnum was suggested to represent the main cause of facial spasm., Conclusions: Although an extremely rare condition, facial spasm can develop as a result of contralateral tumors in locations other than the cerebellopontine angle., (Copyright © 2016 Elsevier Inc. All rights reserved.)
- Published
- 2016
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43. Cranial Base Repair Using Suturing Technique Combined with a Mucosal Flap for Cerebrospinal Fluid Leakage During Endoscopic Endonasal Surgery.
- Author
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Hara T, Akutsu H, Yamamoto T, Tanaka S, Takano S, Ishikawa E, Matsuda M, and Matsumura A
- Subjects
- Adolescent, Adult, Aged, Aged, 80 and over, Cerebrospinal Fluid Leak etiology, Child, Child, Preschool, Drainage, Female, Humans, Lumbar Vertebrae, Male, Middle Aged, Retrospective Studies, Severity of Illness Index, Cerebrospinal Fluid Leak surgery, Neuroendoscopy adverse effects, Nose, Plastic Surgery Procedures methods, Skull Base surgery, Surgical Flaps, Suture Techniques
- Abstract
Objective: To evaluate a cranial base repair method using the dural suturing technique in combination with a mucosal flap in the endoscopic endonasal approach., Methods: We analyzed 190 patients (mean age, 52.3 years; age range, 3-86 years) who underwent 194 endoscopic endonasal approaches. The degree of intraoperative cerebrospinal fluid (CSF) leakage was graded based on previously published criteria: grade 0, absent; grade 1, small; grade 2, moderate; and grade 3, large. Cranial base repair using the dural suturing technique was performed according to the grade of CSF leakage: grades 1 and 2, autologous fat graft anchored by dural suturing covered with a sphenoid sinus mucosal flap, and grade 3, multilayered, inlay sutured and onlay nonsutured fascial grafts covered with a nasoseptal flap., Results: Intraoperative CSF leakage was observed in 125 of 194 cases (64.4%). The degree of CSF leakage was grade 0 in 69 cases, grade 1 in 51 cases, grade 2 in 30 cases, and grade 3 in 44 cases. A postoperative CSF leak was encountered in 2 of 125 repaired cases (1.6%). Both cases with CSF leak involved grade 3 CSF leak (4.5%), and both were successfully treated with lumbar drainage., Conclusion: Our graded cranial base repair method using the dural suturing technique is simple and reliable., (Copyright © 2015 Elsevier Inc. All rights reserved.)
- Published
- 2015
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44. Neuroendoscopy Followed by Radiotherapy in Cystic Craniopharyngiomas--a Long-Term Follow-Up.
- Author
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Takano S, Akutsu H, Mizumoto M, Yamamoto T, Tsuboi K, and Matsumura A
- Subjects
- Adult, Aged, Aged, 80 and over, Biopsy, Craniopharyngioma pathology, Female, Follow-Up Studies, Headache etiology, Humans, Hypopituitarism etiology, Magnetic Resonance Imaging, Male, Memory Disorders etiology, Middle Aged, Neoplasm Recurrence, Local, Pituitary Hormones blood, Pituitary Neoplasms pathology, Retrospective Studies, Suction, Visual Acuity, Craniopharyngioma surgery, Neuroendoscopy methods, Pituitary Neoplasms surgery, Radiosurgery methods
- Abstract
Background: Treatment of cystic craniopharyngiomas is often complicated because of adherence of craniopharyngiomas to adjacent brain structures. A strategy involving neuroendoscopic procedures followed by stereotactic radiotherapy is less invasive, avoiding brain damage. However, long-term follow-up of this strategy has not been investigated in depth., Methods: Cystic craniopharyngiomas in 9 patients were treated with neuroendoscopic cyst aspiration and fenestration, followed by fractionated stereotactic radiotherapy (FSRT). The neuroendoscopic procedure focused on widening of cyst fenestration and extensive irrigation of the cyst contents. FSRT was performed using 6 fixed beams, an 8-mm margin to cover the gross tumor volume with a 95% isodose line, and a target delivered dose of 50.4 Gy in 28 fractions., Results: The median follow-up period was 72.9 months. Tumor control was achieved in 8 of 9 patients (88.9%). Marked tumor volume reduction was obtained with the neuroendoscopic procedure alone (26.1%) at 6 months (20.4%), 1 year (11.0%), and 2 years (3.1%). One recurrent case showed multilobulated cysts, and a second surgery was required 1 year after the treatment. Clinical symptoms such as headache and visual disruption were rapidly alleviated after the neuroendoscopic procedure. No new visual disturbances, endocrinopathy, or hypothalamic dysfunction was observed during follow up., Conclusions: Neuroendoscopic cyst aspiration and fenestration followed by FSRT is a less invasive, powerful strategy for treating adult cystic craniopharyngiomas., (Copyright © 2015 Elsevier Inc. All rights reserved.)
- Published
- 2015
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45. Improvement of Long-term Results with Neoadjuvant Chemotherapy and Radiotherapy for Central Nervous System Germinoma.
- Author
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Takano S, Yamamoto T, Ishikawa E, Akutsu H, Nakai K, Matsuda M, Muroi A, Shibata Y, Mizumoto M, Tsuboi K, and Matsumura A
- Subjects
- Adolescent, Age of Onset, Antineoplastic Agents therapeutic use, Central Nervous System Neoplasms drug therapy, Central Nervous System Neoplasms radiotherapy, Child, Combined Modality Therapy, Disease-Free Survival, Dose-Response Relationship, Radiation, Female, Follow-Up Studies, Germinoma drug therapy, Germinoma radiotherapy, Humans, Kaplan-Meier Estimate, Karnofsky Performance Status, Male, Neoadjuvant Therapy adverse effects, Retrospective Studies, Survival Analysis, Treatment Outcome, Young Adult, Central Nervous System Neoplasms therapy, Germinoma therapy, Neoadjuvant Therapy methods
- Abstract
Objective: To evaluate the role of neoadjuvant chemotherapy and radiotherapy in the treatment of central nervous system germinomas in 38 patients who received definitive treatment and were followed-up >5 years between 1980 and 2009., Methods: The median age at diagnosis and follow-up period were 16.5 years and 128.3 months, respectively. Treatment was irradiation alone or adjuvant platinum-based chemotherapy followed by reduced-dose local irradiation. Seven patients progressed at 12.9-133.9 months and 1 died of disease 89.3 months after therapy initiation., Results: The treatment strategies were divided into 3 groups: group A (1980-1988, n = 5), whole brain with local irradiation; group B (1989-2002, n = 16), chemotherapy with or without reduced irradiation dose; and group C (2003-2009, n = 17): neoadjuvant chemotherapy (3 courses) followed by 30.6 Gy of whole ventricle irradiation for patients with localized complete response, and additional local boost of 19.8 Gy for others. There were 7 recurrent cases, all in group B. The progression-free survival was significantly longer in groups A and C versus group B (P < 0.001). Decreased Karnofsky performance status was observed in 2 (40%), 6 (37.5%), and 0 cases in groups A-C, respectively. The main reasons for the good results in group C might be the neoadjuvant chemotherapy with whole ventricle radiotherapy and introduction of neuroendoscopy, especially for pineal lesions, resulting in a substantial reduction of time from the diagnosis to first treatment., Conclusions: Chemotherapy followed by whole ventricle radiotherapy, with or without local boost, and with use of neuroendoscopy results in good disease control without late complications in patients with germinomas., (Copyright © 2015 Elsevier Inc. All rights reserved.)
- Published
- 2015
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46. Movable intraoperative magnetic resonance imaging incorporating a seismic system.
- Author
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Akutsu H, Yamamoto T, Masuda Y, Ishikawa E, Masumoto T, Matsuda M, and Matsumura A
- Subjects
- Adult, Biopsy, Brain Neoplasms pathology, Equipment and Supplies, Female, Humans, Intraoperative Care, Japan, Male, Middle Aged, Brain Neoplasms surgery, Earthquakes, Facility Design and Construction, Image-Guided Biopsy instrumentation, Magnetic Resonance Imaging instrumentation, Neurosurgical Procedures instrumentation, Operating Rooms, Surgery, Computer-Assisted instrumentation
- Abstract
Introduction: A high-field ceiling-mounted and movable intraoperative MR imaging (iMRI) can minimize additional risks for MRI and enhance safety by not moving the patient. In this system, hanging the heavy magnet from the ceiling requires structural stability; this stability was confirmed in earlier studies, but not proved during a seismic event., Objective: We have installed a 1.5 T movable iMRI system with an incorporated seismic system in our hospital in Japan, a seismic event-prone region. This arrangement is the first in the world, to our knowledge. The objective of this study was to describe the mechanism of this seismic system and the first clinical experience using this system., Methods: The seismic system consists of a stabilizer pad that is mounted directly under the magnet, in addition to the structural stability. The seismic system was tested with using a shaker table testing at a test laboratory., Results: Ninety-one patients underwent neurosurgical intervention using this iMRI and seismic system at our hospital. In all patients, intra-, pre, and/or postoperative MR images were successfully obtained, and image quality was excellent. The workflow of moving the magnet and scanning were smooth and unproblematic. We had 169 seismic events in our city during this time period, but had no incidental or accidental events related to the seismic events., Conclusion: With the use of the seismic system, a ceiling-mounted, movable iMRI system can be more safely used. This seismic system may contribute to the spread of movable iMRI systems in countries where seismic events occur., (Copyright © 2015 Elsevier B.V. All rights reserved.)
- Published
- 2015
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47. Influence of echo time in quantitative proton MR spectroscopy using LCModel.
- Author
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Yamamoto T, Isobe T, Akutsu H, Masumoto T, Ando H, Sato E, Takada K, Anno I, and Matsumura A
- Subjects
- Aspartic Acid analogs & derivatives, Aspartic Acid metabolism, Brain metabolism, Choline metabolism, Creatine metabolism, Humans, Phosphocreatine metabolism, Reproducibility of Results, Brain Neoplasms metabolism, Glioma metabolism, Image Processing, Computer-Assisted methods, Models, Theoretical, Proton Magnetic Resonance Spectroscopy methods
- Abstract
Objective: The objective of this study was to elucidate the influence on quantitative analysis using LCModel with the condition of echo time (TE) longer than the recommended values in the spectrum acquisition specifications., Methods: A 3T magnetic resonance system was used to perform proton magnetic resonance spectroscopy. The participants were 5 healthy volunteers and 11 patients with glioma. Data were collected at TE of 72, 144 and 288ms. LCModel was used to quantify several metabolites (N-acetylaspartate, creatine and phosphocreatine, and choline-containing compounds). The results were compared with quantitative values obtained by using the T2-corrected internal reference method., Results: In healthy volunteers, when TE was long, the quantitative values obtained using LCModel were up to 6.8-fold larger (p<0.05) than those obtained using the T2-corrected internal reference method. The ratios of the quantitative values obtained by the two methods differed between metabolites (p<0.05). In patients with glioma, the ratios of quantitative values obtained by the two methods tended to be larger at longer TE, similarly to the case of healthy volunteers, and large between-individual variation in the ratios was observed., Conclusions: In clinical practice, TE is sometimes set longer than the value recommended for LCModel. If TE is long, LCModel overestimates the quantitative value since it cannot compensate for signal attenuation, and this effect is different for each metabolite and condition. Therefore, if TE is longer than recommended, it is necessary to account for the possibly reduced reliability of quantitative values calculated using LCModel., (Copyright © 2015 Elsevier Inc. All rights reserved.)
- Published
- 2015
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48. Variability in amplitude and stimulation threshold values in motor evoked potential (MEP) monitoring during the resection of brain lesions.
- Author
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Okamoto E, Ishikawa E, Yamamoto T, Matsuda M, Nakai K, Matsushita A, Masuda Y, Akutsu H, Ayuzawa S, Sakamaki F, Matsumoto Y, and Matsumura A
- Subjects
- Adult, Aged, Deep Brain Stimulation standards, Female, Humans, Intraoperative Neurophysiological Monitoring standards, Male, Middle Aged, Prospective Studies, Brain physiology, Brain surgery, Deep Brain Stimulation methods, Evoked Potentials, Motor physiology, Intraoperative Neurophysiological Monitoring methods
- Abstract
Objective: Criteria for motor evoked potential (MEP) monitoring include the amplitude criterion and threshold criterion. The aim of our study for the amplitude criterion during removal of brain lesions was to determine a suitable stimulus intensity that can reduce the variability in amplitudes. We also assessed the usefulness of the threshold criterion and amplitude criterion by comparing the variability between the two methods as a preliminary study., Methods: Seventeen patients including 12 cases with no neurological deterioration after surgery were enrolled in this study. The amplitudes in various stimulus intensities and the stimulation threshold (ST) were repeatedly measured during surgery. The stimulus intensities used in the amplitude criterion are described as 'the ST just after dura opening (ST(0))+additional intensity'. The variability was assessed with the coefficient of variation (CV)., Results: With direct cortical stimulation (DCS), the CVs of amplitudes were significantly lower at stimulus intensities of more than ST(0)+4 mA, with the smallest at ST(0)+10 mA. The CV of STs was significantly smaller than that of amplitudes., Conclusions: The variability in the amplitude criterion was significantly reduced using stimulus intensities of more than ST(0)+4 mA. The variability in the threshold criterion was significantly smaller than that of the amplitude criterion, even when using a strong stimulus intensity., Significance: The maximal stimulus intensity with no body motion should be used in the amplitude criterion for intraoperative MEP elicited by DCS., (Copyright © 2014 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.)
- Published
- 2015
- Full Text
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49. Sleep, cardiac autonomic function, and carotid atherosclerosis in patients with cardiovascular risks: HSCAA study.
- Author
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Kadoya M, Koyama H, Kurajoh M, Kanzaki A, Kakutani-Hatayama M, Okazaki H, Shoji T, Moriwaki Y, Yamamoto T, Emoto M, Inaba M, and Namba M
- Subjects
- Actigraphy, Adult, Aged, Carotid Arteries diagnostic imaging, Carotid Artery Diseases diagnosis, Carotid Artery Diseases epidemiology, Carotid Intima-Media Thickness, Chi-Square Distribution, Cross-Sectional Studies, Female, Heart Rate, Humans, Japan epidemiology, Logistic Models, Male, Middle Aged, Multivariate Analysis, Odds Ratio, Plaque, Atherosclerotic, Risk Factors, Severity of Illness Index, Autonomic Nervous System physiopathology, Carotid Artery Diseases physiopathology, Heart innervation, Sleep
- Abstract
Objectives: Behavioral and psychosocial factors have been gaining increased attention in regard to cardiovascular diseases. We evaluated sleep conditions, cardiac autonomic function, and carotid atherosclerosis in subjects who participated in the Hyogo Sleep Cardio-Autonomic Atherosclerosis (HSCAA) Study., Methods: This cross-sectional study included 330 serial patients registered in the HSCAA study who were free from past cardiovascular diseases, and prescribing α- or β-blockers. In addition to clinical background and classical cardiovascular risk factors, sleep efficiency, apnea hypopnea index (AHI), awake physical activity, heart rate variability (HRV), carotid intima-media thickness (IMT), presence of plaque and plaque score were determined., Results: Sleep efficiency (r = -0.183) and all HRV parameters (SDNN: r = -0.202; rMSSD: r = -0.234; pNN50: r = -0.277) were significantly (p < 0.01) and negatively associated with IMT, while AHI (r = 0.220, p < 0.001) was positively associated with IMT. Similarly, sleep efficiency (r = -0.129), HRV parameters (SDNN: r = -0.170; rMSSD: r = -0.217; pNN50: r = -0.260) and AHI (r = 0.184) were also significantly (p < 0.05) associated with plaque scores. Multivariate logistic regression analyses showed that rMSSD, but not sleep efficiency or AHI, was significantly associated with carotid plaque (OR 0.74, 95% CI 0.56-0.98, p = 0.037), independent of classical risk factors. The association of rMSSD with carotid plaque remained significant even after adjustment for sleep efficiency or AHI. A comparison of risk factors in specific subgroups showed that the association of lower HRV with carotid plaque was more prominent in patients with cardiovascular risk factors including male gender, hypertension, dyslipidemia and diabetes mellitus., Conclusion: Cardiac autonomic nervous dysfunction was independently associated with carotid atherosclerosis, independent of sleep condition. Moreover, that association was more prominent in specific subgroups with cardiovascular risk factors., (Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.)
- Published
- 2015
- Full Text
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50. Long-term survival after treatment of glioblastoma multiforme with hyperfractionated concomitant boost proton beam therapy.
- Author
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Mizumoto M, Yamamoto T, Takano S, Ishikawa E, Matsumura A, Ishikawa H, Okumura T, Sakurai H, Miyatake S, and Tsuboi K
- Subjects
- Adult, Aged, Antineoplastic Agents, Alkylating therapeutic use, Brain Neoplasms drug therapy, Chemoradiotherapy, Dacarbazine analogs & derivatives, Dacarbazine therapeutic use, Dose Fractionation, Radiation, Female, Glioblastoma drug therapy, Humans, Male, Middle Aged, Nimustine therapeutic use, Prognosis, Radiotherapy Planning, Computer-Assisted methods, Survival Analysis, Temozolomide, Brain Neoplasms radiotherapy, Glioblastoma radiotherapy, Proton Therapy methods
- Abstract
Purpose: Although conventional x-ray therapy of 60 Gy in 30 fractions is generally used in our institute as well as others, the prognosis of patients with glioblastoma multiforme (GBM) is poor. The purpose of this study was to evaluate the characteristics of long-term GBM survivors after postoperative hyperfractionated concomitant boost x-ray radiation therapy and proton beam therapy., Methods and Materials: Twenty-three of 81 GBM patients who met the eligible criteria and consented to the protocol were treated with x-ray radiation therapy (50.4 Gy in 28 fractions in T2-high areas) and proton beam therapy (46.2 GyE in 28 fractions in gadolinium-enhanced volumes >6 hours after x-ray radiation therapy) concurrent with nimustine hydrochloride or temozolomide., Results: Treatment was completed in all patients within 38-50 days (median, 43 days). Six currently living patients (median follow-up period, 70.9 months) developed radiation necrosis without tumor recurrence. Of these, 5 underwent necrotomy and 2 received bevacizumab after necrotomy. Compared with the pretreatment status, the Karnofsky performance scale (KPS) for the 6 survivors decreased by 10%-30% at the last follow-up. However, radiation necrosis had been well controlled and 5 of 6 patients maintained a stable KPS without hospital care., Conclusions: The results suggest that high-dose proton beam therapy could control GBM pathogenesis if the treatment area completely covers tumor infiltration. Although radiation necrosis was inevitable, the remaining brain volume was fairly well preserved in the long-term survivors., (Copyright © 2015 American Society for Radiation Oncology. Published by Elsevier Inc. All rights reserved.)
- Published
- 2015
- Full Text
- View/download PDF
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