7 results on '"Yada H"'
Search Results
2. Leak Test off Rubber Gaskets
- Author
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KOBAYASHI, S., primary, YADA, H., additional, and Nakagawa, Hiroshi, additional
- Published
- 1960
- Full Text
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3. Characterization of tolvaptan response and its impact on the outcome for patients with heart failure.
- Author
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Hitomi Y, Nagatomo Y, Yukino M, Yumita Y, Kagami K, Yasuda R, Toya T, Namba T, Masaki N, Yada H, and Adachi T
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- Aged, Antidiuretic Hormone Receptor Antagonists, Benzazepines, Humans, Male, Patient Discharge, Retrospective Studies, Tolvaptan, Aftercare, Heart Failure drug therapy
- Abstract
Background: Conventional diuretic therapy such as loop diuretics is a cornerstone of the treatment for heart failure (HF). Diuretic response is an important factor in determining resistance to HF therapy and has been shown to be associated with subsequent clinical outcome. Tolvaptan (TVP), a vasopressin V2 receptor antagonist, has a favorable profile in terms of rapid fluid removal and less aggravation of renal function. We hypothesized that the response to TVP might be associated with the subsequent clinical outcome., Method: In this single-center retrospective study, 148 consecutive HF patients who were administered TVP from 2014 through 2018 [age 79 (69-86) years, male 89 (60%)] were included. Ninety-six patients were divided into TVP responder [N = 39 (41%)] and non-responder groups based on the cut-off value of gained urine output (+ 93 ml/mg TVP /day) on the day after TVP was introduced., Results: Early TVP introduction (p = 0.012) and lower dose of loop diuretics (p = 0.043) were predictors of TVP responder. For 2 years after discharge, TVP responders showed more favorable outcomes regarding the primary endpoint defined as the composite of all-cause death and HF readmission (p = 0.034, log-rank test) and HF readmission (p = 0.005). A multivariable Cox model analysis revealed that TVP responder was an independent predictor of the primary endpoint (hazard ratio 0.48, p = 0.041). TVP responders had a lower number of HF readmissions over a 1-year period (p = 0.002). TVP response was independently associated with the number of HF readmissions (p = 0.015). The proportion of patients with an extended period between discharge and HF readmission after TVP administration was higher in responders than non-responders (67% vs. 23%, p = 0.006). These associations of TVP response and post-discharge outcomes were more evident in patients who continued TVP after discharge., Conclusion: TVP response can be indicative of subsequent clinical outcomes and may be informative when considering advanced care planning., Competing Interests: Declaration of Competing Interest None, (Copyright © 2021. Published by Elsevier Ltd.)
- Published
- 2021
- Full Text
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4. Usefulness of the d-ROMs test for prediction of cardiovascular events.
- Author
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Masaki N, Sato A, Horii S, Kimura T, Toya T, Yasuda R, Namba T, Yada H, Kawamura A, and Adachi T
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- Aged, Cause of Death, Disease Progression, Female, Humans, Japan epidemiology, Male, Middle Aged, Myocardial Revascularization statistics & numerical data, Predictive Value of Tests, Prognosis, Reactive Oxygen Species analysis, Risk Assessment methods, Risk Factors, Cardiovascular Diseases diagnosis, Cardiovascular Diseases metabolism, Cardiovascular Diseases mortality, Cardiovascular Diseases therapy, Oxidative Stress physiology
- Abstract
Background: d-ROMs test developed to determine the degree of individual oxidative stress may predict cardiovascular events., Methods and Results: 265 patients (204 men, 61 women; age, 65±13years) who had been treated for cardiovascular disease were divided evenly by quartile of baseline d-ROMs levels, and were followed up. During the observation periods of 2.66±1.47years, there were 14 (5%) deaths, 8 (3%) cardiovascular deaths, 13 (5%) major adverse cardiovascular events (MACEs), and 51 (19%) all cardiovascular events including heart failure, cardiovascular surgery, and revascularization. Log-rank tests demonstrated that the patients in the 4th quartile (d-ROMs≧395.00U.CARR) had a higher incidence rate of cardiovascular death than those in the 2nd quartile (d-ROMs 286.00-335.00, p=0.022). In multivariate Cox regression analysis, even after adjustment for age, sex, coronary risk factors, C-reactive protein, and renal function, high d-ROMs was a risk factor for all-cause death [adjusted HR of 4th vs. 1st quartile, 10.791 (95% confidence interval 1.032-112.805), p=0.047], and all cardiovascular events [HR of 4th vs. 1st quartile, 2.651 (95% confidence interval 1.138-6.177), p=0.024]., Conclusions: Our results suggest that d-ROMs is a useful oxidative stress marker to assess prognosis and risk of further cardiovascular events., (Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.)
- Published
- 2016
- Full Text
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5. Association between brachial-ankle pulse wave velocity and the ratio of l-arginine to asymmetric dimethylarginine in patients undergoing coronary angiography.
- Author
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Masaki N, Hakuno D, Toya T, Shiraishi Y, Kujiraoka T, Namba T, Yada H, Kimura K, Miyazaki K, and Adachi T
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- Aged, Arginine drug effects, Blood Pressure drug effects, Coronary Artery Disease blood, Coronary Artery Disease surgery, Cross-Sectional Studies, Female, Heart Rate drug effects, Hematocrit, Hemoglobins drug effects, Humans, Kidney physiopathology, Male, Middle Aged, Natriuretic Peptide, Brain drug effects, Vascular Stiffness drug effects, Ankle Brachial Index, Arginine analogs & derivatives, Arginine blood, Coronary Angiography drug effects, Pulse Wave Analysis
- Abstract
Background: Endothelial dysfunction causes vasomotor dysregulation and vascular stiffening in addition to structural changes. By influencing NO synthesis, deficiency of l-arginine relative to asymmetric dimethylarginine (ADMA), which is an l-arginine derivative that acts as a competitive NO synthase inhibitor, may lead to the promotion of arterial stiffness. This study investigated the relationship between the l-arginine/ADMA ratio and brachial-ankle pulse wave velocity (baPWV), an indicator of arterial stiffness., Methods and Results: This cross-sectional study enrolled 74 patients (62 men, 12 women; mean age, 67±10 years) undergoing elective coronary angiography. A total of 54 (73%) patients had coronary artery disease. Serum l-arginine and ADMA were measured by high-performance liquid chromatography with fluorescence detection. The ratio of l-arginine to ADMA and the serum l-arginine level was associated with baPWV in univariate regression analysis (l-arginine/ADMA ratio: β=-0.323, p=0.005; l-arginine: β=-0.247, p=0.034). In addition, baPWV was related to blood hemoglobin concentration, hematocrit, brain natriuretic peptide level, symmetric dimethylarginine, renal function, blood pressure, and heart rate. In multivariate analysis, the l-arginine/ADMA ratio was a significant predictor of baPWV (β=-0.310, p<0.001). In subgroup analyses, the l-arginine/ADMA ratio was associated with baPWV in elderly patients (n=46, β=-0.359, p=0.004), and in younger patients (n=28, β=-0.412, p=0.006)., Conclusion: A low l-arginine/ADMA ratio may be associated with high baPWV in patients undergoing coronary angiography., (Copyright © 2014 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved.)
- Published
- 2015
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6. Suppression of Rad leads to arrhythmogenesis via PKA-mediated phosphorylation of ryanodine receptor activity in the heart.
- Author
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Yamakawa H, Murata M, Suzuki T, Yada H, Ishida H, Aizawa Y, Adachi T, Kamiya K, and Fukuda K
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- Action Potentials drug effects, Animals, Arrhythmias, Cardiac metabolism, Arrhythmias, Cardiac physiopathology, Caffeine pharmacology, Calcium Signaling, Cyclic AMP-Dependent Protein Kinases genetics, Gene Expression Regulation, Mice, Mice, Transgenic, Mutation, Myocardium metabolism, Myocardium pathology, Myocytes, Cardiac drug effects, Myocytes, Cardiac metabolism, Myocytes, Cardiac pathology, Phosphorylation, Primary Cell Culture, Ryanodine Receptor Calcium Release Channel genetics, Sarcoplasmic Reticulum drug effects, Sarcoplasmic Reticulum metabolism, ras Proteins deficiency, Arrhythmias, Cardiac genetics, Calcium metabolism, Cyclic AMP-Dependent Protein Kinases metabolism, Ryanodine Receptor Calcium Release Channel metabolism, ras Proteins genetics
- Abstract
Ras-related small G-protein Rad plays a critical role in generating arrhythmias via regulation of the L-type Ca(2+) channel (LTCC). The aim was to demonstrate the role of Rad in intracellular calcium homeostasis by cardiac-Specific dominant-negative suppression of Rad. Transgenic (TG) mice overexpressing dominant-negative mutant Rad (S105N Rad TG) were generated. To measure intracellular Ca(2+) concentration ([Ca(2+)]i), we recorded [Ca(2+)]i transients and Ca(2+) sparks from isolated cardiomyocytes using confocal microscopy. The mean [Ca(2+)]i transient amplitude was significantly increased in S105N Rad TG cardiomyocytes, compared with control littermate mouse cells. The frequency of Ca(2+) sparks was also significantly higher in TG cells than in control cells, although there were no significant differences in amplitude. The sarcoplasmic reticulum Ca(2+) content was not altered in the S105N Rad TG cells, as assessed by measuring caffeine-induced [Ca(2+)]i transient. In contrast, phosphorylation of Ser(2809) on the cardiac ryanodine receptor (RyR2) was significantly enhanced in TG mouse hearts compared with controls. Additionally, the Rad-mediated RyR2 phosphorylation was regulated via a direct interaction of Rad with protein kinase A (PKA)., (Copyright © 2014 Elsevier Inc. All rights reserved.)
- Published
- 2014
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7. Mulberry anthracnose antagonists (iturins) produced by Bacillus amyloliquefaciens RC-2.
- Author
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Hiradate S, Yoshida S, Sugie H, Yada H, and Fujii Y
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- Antifungal Agents pharmacology, Bacillus growth & development, Peptides, Cyclic isolation & purification, Peptides, Cyclic pharmacology, Spectrum Analysis, Antifungal Agents isolation & purification, Bacillus metabolism, Fungi drug effects, Morus microbiology, Peptides, Cyclic biosynthesis
- Abstract
Bacillus amyloliquefaciens strain RC-2 produced seven antifungal compounds (1-7) secreted into the culture filtrate. These compounds inhibited the development of mulberry anthracnose caused by the fungus, Colletotrichum dematium. Chemical structural analyses by NMR and FAB-MS revealed that all these compounds were iturins (cyclic peptides with the following sequence: L-Asn --> D-Tyr --> D-Asn --> L-Gln --> L-Pro --> D-Asn --> L-Ser --> D-beta-amino acid -->) and compounds 1-6 are identical to iturins A-2-A-7, respectively. Compound 7 (iturin A-8) is a new iturin, which has a -(CH(2))(10)CH(CH(3))CH(2)CH(3) group as a side chain in the beta-amino acid in the molecule.
- Published
- 2002
- Full Text
- View/download PDF
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