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Gold–Platinum (Au–Pt) alloy demonstrates considerable promise as a material for spacecraft proof mass, due to its ultra-low magnetic susceptibility. This study systematically investigates the effect of heat treatment on the microstructure evolution, magnetic properties, and mechanical performance of the Au72Pt28 alloy. The results indicate that the Pt-rich phase can be precipitated by discontinuous precipitation (DP) and continuous precipitation (CP) reactions. There is a competition between the two precipitation behaviors of Pt-rich phase, which is closely related to their diffusion path. With increasing ageing time and temperature, the discontinuous precipitates gradually coarsen and extend from grain boundaries into grain interior, while the Pt-rich phase nanoparticles precipitated by CP reaction uniformly distribute in the grain interior. Besides, the volume fraction of Pt-rich phase gradually increases, resulting in the increase of magnetic susceptibility. The coarsening of discontinuous precipitates is the main reason for the decrease in the nanoindentation hardness, and it increases rapidly due to a large number of intragranular Pt-rich phase nanoparticles.

An in-depth understanding of the bimodal scale particle reinforced composites, including the particle content and size, phase constitution and distribution, and their effects on mechanical properties and deformation mechanisms, is essential to advance the study of high performance high entropy alloys (HEAs). In this study, the bimodal-sized (nano + micron)(N + M)-Al2O3P/CoCrFeMnNi reinforced composites and monomadal-sized micron(M)-Al2O3P/CoCrFeMnNi reinforced composites were successfully fabricated using a two-step ball milling process in conjunction with spark plasma sintering (SPS) technology. Results showed that the Al2O3P/CoCrFeMnNi composites primarily consisted of fcc structure, with Al2O3 and MnAl2O4 as secondary phases. The M-Al2O3P reinforced composites contained obvious heterogeneous structure while (N + M)-Al2O3P reinforced composites exhibited a multi-scale grain structure comprising of double-sized reinforcement and multiple-sized matrix grains. The yield strength (YS) of bimodal-size particle reinforced composites was higher than that of monomadal particle reinforced composites. For example, the YS of (N-5)/(M − 5) and (N-5)/(M − 10) composites was 117% and 133% higher than that of HEA, respectively. Intriguingly, (N + M)-Al2O3P reinforced composites effectively addressed the issue of reduced material strength caused by a high concentration of particles with a monomadal size. Moreover, the composites of (N-5)/(M − 5) and (N-5)/(M − 10) with a high content of lightweight Al2O3P effectively contributed to the reduction in density of HEA, exhibiting a decrease by 11% and 17% compared to pure HEA, respectively.

Abnormal regional variations in electrical and calcium homeostasis properties have been implicated in catecholaminergic polymorphic ventricular tachycardias (CPVT) attributable to abnormal RyR2-mediated store Ca2+ release, but their underlying mechanism have not been well explored in intact hearts. Methods: We performed in vivo and ex vivo studies including high throughput mapping of Ca2+ transients (CaT) and transmembrane voltage (Vm) in murine wild-type (WT) and heterozygous RyR2-R2474S/+ hearts, before and during isoprenaline (ISO) challenge. Results: ISO-challenged RyR2-R2474S/+ showed increased incidence of arrhythmia accompanied by abnormal Ca2+ transients compared to WT. CaT duration (CaTD) in the LV apex amongst regions studied both before and during ISO challenge in both WT and RyR2-R2474S/+ ventricles. RyR2-R2474S/+ ventricles showed prolonged CaTD, both before and during isoprenaline (ISO) challenge. Conversely, action potential durations (APD) were the same in WT and RyR2-R2474S/+ ventricles and identically reduced by ISO challenge. RyR2-R2474S/+ showed Vm-CaT latencies at time to half decay, but not rise time to peak, which were significantly prolonged compared to WT in all ventricular regions examined with ISO challenge. Following burst pacing, ventricular localized concordant alternans in CaT and APD were readily observed in RyR2-R2474S/+ but not in WT mice. Such CaT and APD alternans occurred mostly semiannually in specific regions of the ventricular pre-occurrence of VT. Conclusion: The pro-arrhythmic RyR2-R2474S/+ phenotype in intact hearts thus directly parallels delayed regional CaT recovery properties and alteration of Vm-CaT latencies. Studies suggest that discordant localized calcium alternans are mechanistically responsible for action potential duration alternans and occurrence of VT in RyR2-R2474S/+ mice.

The paper comprehensively describes the evolution of metastable microstructures in a cast low-Ta-containing γ-TiAl alloy during cooling-tempering-lamellarization heat treatments. The behavior and mechanism of microstructure refinement are discussed. The rapid cooling generates metastable microstructures, including Widmanstätten, feathery, and massive structures, with many γ variants in small sizes and different orientations. It significantly refines the coarsened colonies and randomizes the texture. The tempering can effectively stabilize the metastable microstructures. During tempering, the γ→α phase transformation is more active at higher temperatures while coarsening and recrystallization dominate at lower temperatures. After tempering, a refined microstructure with spherical grains and convoluted structures forms. Subsequent lamellarization treatment optimizes the microstructure and obtains a fine-grained nearly-lamellar microstructure with small colonies (∼70 μm) and dispersed fine γ grains (∼10 vol%), which yielded a 1.0 % elongation with a 487 MPa yield strength (0.2%) and a 589 MPa ultimate tensile strength at room temperature. Finally, the unique promotion effects and mechanism of a small amount of Ta addition on the nucleation, growth, evolution, and stabilization of metastable microstructures are concluded and discussed, which is crucial for the refinement of cast γ-TiAl alloy by heat treatment alone.

Introduction: Many breast cancer patients suffer from fear of cancer recurrence (FCR). However, effective physical intervention for FCR has been scarce. Previous studies have confirmed that repetitive transcranial magnetic stimulation (rTMS) can help improve patients' anxiety, depression, fear, and stress level. Therefore, this study aims to assess the efficacy of rTMS in the treatment of FCR in breast cancer patients and explore its underlying neural mechanism. Methods and analysis: and analysis: Fifty breast cancer patients with high FCR (FCR total score >27), and fifty age- and gender-matched patients with low FCR (FCR total score

Although the catalytic properties of Au–Pt alloys have received widespread attention, there are a few of relevant studies on their microscopic deformation process. Considering that Au–Pt alloys are noble metals, and the costs of experiments are extremely high. Direct research experiments are extremely expensive. So the molecular dynamics method which can directly observe the evolution process of microstructure and analyze the mechanical behavior of each deformation stage of the material was adopted to explore the underlined relationship between the temperature and the compression deformation mechanism. The results show that during the process of compression deformation, lots of atoms in the crystal are converted into boundary atoms, the dislocation multiplication and the grain fragmentation occur. In different temperature intervals, along with the compression deformation, low temperature, medium temperature and high temperature recovery appear. Due to the influence of the dual mechanism of deformation and recovery, the deformation mechanism is different at different temperatures, at low temperature stage is mainly the dislocation multiplication and the grain fragmentation, at middle temperature stage is the combination of the opposite sign dislocation, and at high temperature stage is mainly the merger of the grain.

In the present work, novel nano-Al2O3p reinforced heterogeneous CoCrFeMnNi matrix composites with 0–7.5 wt% Al2O3p were fabricated by mechanical alloying (MA) and spark plasma sintering (SPS) method. The microstructure evolution and properties, i.e., density, hardness and room temperature compression were systematically studied. The results show that different degrees of heterogeneous matrix organization occurred in the composites. The CoCrFeMnNi-2.5 wt%Al2O3p composite consists of CG region and UFG region of uniformly distributed nano-Al2O3p. And the addition of nano-Al2O3p can effectively refine the matrix grains. Compared to pure HEA, the grain size of CoCrFeMnNi-5.0 wt%Al2O3p composite is refined by 48.5%. With the increase of nano-Al2O3 content, the hardness values of the composites increased by 23.6%–56.7% than those of pure HEA. Among the nanocomposites, the CoCrFeMnNi-5.0 wt%Al2O3p composite exhibits the best strengthening effect, while the CoCrFeMnNi-2.5 wt%Al2O3p composite shows a superior strong-plastic synergistic effect with yield strength, ultimate compressive strength and fracture strain of 913 MPa, 1935 MPa and 38%, respectively. However, with the Al2O3p content further increases to 7.5 wt%, both the strength and plasticity of the composite decrease due to the serious agglomeration of nanoparticles.

The Ni61Fe10Cr10Al17Mo2 high-entropy alloys (HEAs) with low density have been developed with great potentials for applications. The forging process is one of the important methods for fabricating components. Accordingly, the study of the deformation behavior of HEAs is the essence in the processing and molding of this material for using in industry. Moreover, there are multiple phases with hierarchical structures in the as-cast Ni61Fe10Cr10Al17Mo2 alloys, with the face-centered cubic (FCC) phase as the matrix phase accompanied with hard body-centered cubic (BCC) B2 phase. Here, the hot deformation behaviors of the homogenized Ni61Fe10Cr10Al17Mo2 alloy were investigated at strain rates ranging from 0.001 to 1.0 s−1 and temperatures ranging from 1000 to 1200 °C via isothermal compression tests. The true stress-strain curves were used to reveal the relationship between the flow stress and the deformation temperature and strain rate. The constitutive equations describing the correlations between the flow stress and hot compression parameters were constructed. At the same time, the dynamic material model and instability criterion were used to plot the hot processing map. Furthermore, the deformed microstructures and the dynamic recrystallization of alloy were investigated. Combined with the processing map, the optimal processing route is obtained.

The effects of Ta alloying on the isothermal oxidation behavior and mechanism of a cast Ti-48Al-3Nb-1.5Ta (at.%) TiAl alloy are investigated. It exhibits excellent oxidation resistance with mass gains of 0.95 and 1.29 mg·cm−2 after 900 °C oxidation for 100/200 h in the air, similar to 8 at.% Nb-containing TiAl alloys. The oxide scale shows a complex multi-layer structure, where the Al2O3 layer and continuous dense nitride layer act as protective layers against diffusion and metal oxidation. The oxidation mechanisms are discussed thermodynamically and kinetically. Compared with Nb, Ta is more significant in inhibiting diffusion and promoting the formation of the protective continuous nitride layer, thus being more effective in improving the oxidation resistance of cast TiAl alloy. Consequently, without considering the influence of microstructure, the oxidation resistance of cast Nb-containing TiAl alloy can be further improved by replacing some Nb with a small amount of Ta. It is supposed to provide new insights into the design of oxidation-resistant TiAl alloys.

The novel loquat cultivar ‘Chunhua No.1′ (CH1) is a promising commercial cultivar. However, CH1 has texture characteristics different from those of common loquat, and its formation mechanism remains unclear. Here, we first identified the phenolic compounds of CH1 and its parent (‘Dawuxing’, DWX) and the effect on texture formation. The special presence of stone cells explained the flavor differences in CH1. Chlorogenic acid, neochlorogenic acid, and coniferyl alcohol were the main phenolic compounds in loquat, and the high content of coniferyl alcohol was a potential factor for the rough texture of CH1. Transcriptome reveals that phenylpropanoid metabolism was activated during CH1 fruit texture formation. Kyoto Encyclopedia of Genes and Genomes (KEGG) identified 51 structural genes involved in phenylpropanoid biosynthesis, and Weighted Gene Co-expression Network Analysis (WGCNA) identified four structural genes and 88 transcription factors. These findings provide new insights into the phenolic metabolism and flavor formation of loquat fruit.

The Al2O3 coating on continuous TiNb fiber can effectively suppress the interfacial reaction in TiNbf/TiAl composites. Some phase transitions in fiber have been founded and their formation reason was analyzed. The micromechanical properties of each phase and macroscopic mechanical properties of the composites were also systematically studied. The α+β duplex structure exhibiting texture feature was found in the most regions of TiNb fiber. Meanwhile α+δ layer, σ layer, outer α layer, and β layer would be formed respectively within 10 μm of the fiber surface whose formation reasons were explained from thermodynamics dominated by Al element. Nanoindentation tests indicated the deformation capacity of each phase satisfied: β＞δ＞σ＞α (outer)＞α (inner)＞Al2O3 coating. The composite with coated fibers has excellent fracture strength of 498 MPa and the fracture toughness of 18.72 MPa m, which was benefited from the fine grain strengthening and precipitation strengthening mechanisms. The Al2O3 coating can significantly improve the thermal stability of the composites during thermal exposure below 1250 °C, and keep the mechanical properties from degradation. This work is of great significance for understanding the phase transformation and deformation process of innovative Al2O3 coated TiNb fiber reinforced TiAl matrix composites.

Titanium dioxide (TiO2) is widely used in various fields, and doped TiO2 exhibits different characteristics in different fields. Although numerous studies of Fe-doped TiO2 have been reported, they mainly analyze the influence of Fe on TiO2. The behavior of Fe during the phase transition of TiO2 has been rarely studied. To explore the continuous behavior of Fe during the phase transition of Fe-doped TiO2, the real-time phase transitions of Fe-doped and pure TiO2 at 300–1000 °C were characterized using high-temperature in-situ X-ray diffraction (XRD). Based on the experimental results, models of Fe-doped TiO2 were established using density functional theory (DFT). By comparing the calculated and refined values of the in-situ XRD data of Fe-doped TiO2 and an analysis of the defect formation energies, the evolution of Fe was as follows: Fe is located at a lattice interstice of anatase with an oxygen vacancy → Fe at a Ti site in anatase with an oxygen vacancy → Fe at a Ti site in rutile with an oxygen vacancy → Fe at a Ti site in rutile without an oxygen vacancy. This study reveals the deep connection between the microscopic properties of Fe and the phase transition of Fe-doped TiO2 and clarifies the states of Fe. It provides a theoretical basis for determining the states of doped atoms during the phase transition of TiO2 and theoretical guidance for research regarding the phase transitions of doped TiO2 systems.

Microstructural development and mechanical properties of tungsten heavy alloy, WHA, with FeNiCoCrMn high entropy alloy, HEA, binder were investigated and compared to conventional WHA using Fe–Ni binder. Both WHAs, with HEA and conventional Fe–Ni binders, were fabricated by hot isostatic pressing at a temperature of 1450 °C in an argon environment. Scanning electron microscopy revealed that WHA with HEA and conventional binders possessed uniform and well-refined microstructures. Energy dispersive spectroscopy and X-ray diffraction, XRD, spectroscopy validated the formation and composition of HEA, existing as a skeletal network surrounding tungsten grains. HEA binder exhibited an overall increase of 42% in micro Vickers hardness values. Furthermore, hardness values of the tungsten heavy alloy were also seen to rise when fabricated with HEA binder. However, WHA sample with HEA binder was seen to undergo faster strain hardening and a premature failure, leading to lower values of ultimate strength and reduced ductility.

The unique cellular structure has been reported to be the dominant reason for the remarkable mechanical properties in laser powder-bed fusion (LPBF) superalloys. However, the specific strengthening mechanism of the cellular structure needs to be further researched. In this study, the microstructure and tensile properties of a composition-optimized Haynes 230 alloy fabricated by the LPBF method were systematically investigated. The post-heated HT1 and HT2 samples with different cellular and grain structures served as the reference. The results show that the micron-scale grain and submicron-scale cellular structures are present in the as-built (AB) sample. The cellular boundaries are characterized by solute Nb segregation and high-density dislocations. The tensile tests show that the AB sample illustrates excellent tensile properties with ultimate tensile strength (UTS) of 1180.2 MPa, yield strength (YS) of 842.5 MPa and elongation (EL) of 29.3 %. The high YS mainly results from the strengthening effects of the cellular structure, which can be considered as a combination of dislocation and elemental segregation strengthening. The contribution of cellular structure to YS is much higher than that of GB strengthening. Furthermore, the deformation incompatibility of heterogeneous grain and cellular structures leads to high hetero-deformation induced (HDI) strengthening, which is also the primary reason for the abnormal upturn of strain hardening rate (SHR) in the AB sample.

The RAN Guanine Nucleotide Release Factor (RANGRF) gene encodes the protein MOG1, which binds to Nav1.5 and facilitates its transport to the cell membrane. Nav1.5 mutations have been linked to various cardiac arrhythmias and cardiomyopathy. To investigate the role of RANGRF in this process, we utilized the CRISPR/Cas9 gene editing system to generate a homozygous RANGRF knockout hiPSC line. The availability of the cell line will prove to be an invaluable asset in the study of disease mechanisms and the testing of gene therapies for cardiomyopathy.

Schizophrenia is a group of common psychosis of unknown etiology and GRIN2A gene has been a risk gene for schizophrenia. In order to understand the relationship between the GRIN2A and schizophrenia, we generated a GRIN2A-KO human embryonic stem cell line by CRISPR/Cas9 system, which could provide a valuable resource for investing pathogenic mechanisms underlying schizophrenia and facilitating the development of targeted medicine.

In present work, a novel γ′′-strengthened Nb-alloyed medium-entropy alloy (MEA) was successfully fabricated and systematically investigated. Our results evidence that the γ′′ phase brings out significant precipitation hardening effect (∼10.2 %volume fraction contributes ∼ 685 MPa strength enhancement). The metastable γ′′ phase could abnormally transform to ε phase, and the morphology and distribution of ε phase shows great impacts on mechanical properties. A hetero-lamellae grain coupling with dual-precipitation (HLG + dual-P) structure was successfully constructed in this Nb-alloyed MEA, which could effectively combine precipitation hardening and hetero-deformation induced (HDI) hardening effects. Deformation characters investigations reveals that the absence of mechanical twinning in γ′′-strengthened MEA originates from the improved critical twinning stress related to the fine dislocation source size and the difficulty of high-energy complex SFs reordering. The combination of massive stacking-faults, Lomer-Cottrell locks and dynamically reinforced HDI hardening contribute to the excellent ductility and work-hardening capacity at high-level strength in the HLG + dual-P structural alloy. Our work provides a useful insight and helpful guidance for developing high-performance precipitation-hardened multi-principal element alloys.

Introduction: Savolitinib has been found to have encouraging antitumor activity and a favorable safety profile in Chinese patients with pulmonary sarcomatoid carcinoma and other NSCLCs with MET exon 14 skipping alterations (MET ex14 positive) at the primary analysis of a phase 2 study. Here, we present the long-term efficacy and safety data of savolitinib, including subgroup analyses. Methods: This multicenter, single-arm, open-label, phase 2 study in the People’s Republic of China enrolled MET inhibitor-naive adults with locally advanced or metastatic METex14-positive NSCLC (NCT02897479). Oral savolitinib at a dose of 400 or 600 mg was administered once daily (body weight dependent). The primary objectives of the final analysis were long-term overall survival (OS) and subgroup analyses by previous systemic treatment, NSCLC subtypes, and brain metastases. Results: At the final analysis cutoff date (June 28, 2021), a total of 70 patients were enrolled and receiving savolitinib, and median follow-up was 28.4 (interquartile range: 26.2–36.3) months. The median OS was 12.5 months (95% confidence interval [CI]: 10.5–21.4 [18- and 24-mo OS rates, 42.1% and 31.5%, respectively]). Median OS in pretreated or treatment-naive patients was 19.4 (95% CI: 10.5–31.3) and 10.9 (95% CI: 7.5–14.0) months, respectively; it was 10.6 months (95% CI: 4.6–14.0) in patients with pulmonary sarcomatoid carcinoma, 17.3 months (95% CI: 10.6–23.6) in other NSCLC subtypes, and 17.7 months (95% CI: 10.5–not evaluable) in patients with brain metastases. No new safety signals emerged with prolonged follow-up and exposure. Conclusions: The updated results further confirm the favorable benefit and acceptable safety of savolitinib in Chinese patients with METex14-positive NSCLC.

Ultrasonic surface rolling technology is a new mechanical surface treatment technology that can improve the surface integrity, increase the amplitude and depth of the residual compressive stress layer and improve the fatigue property of metal materials. In this paper, the effect of ultrasonic rolling on the surface layer's microstructure and properties of Ti6Al4V alloys is investigated. The microstructure, surface roughness, surface topography, microhardness and residual stress were used to characterise the surface-modified layer. Specimens treated by ultrasonic surface rolling obtained the smallest surface roughness (0.231 μm) and largest plastic deformation depth (304.38 μm), simultaneously, under sixteen processing stage numbers. The rule of surface compressive residual stress distribution had a similar tendency to the law of surface microhardness distribution. Furthermore, the grain size of the strengthened surface layer decreased, the texture type changed and the Schmidt factor increased compared with the matrix. The increase of microhardness and residual stress is due to grain refinement and dislocation strengthening.

ABSTRACT: Background: Generalized anxiety disorder (GAD) is a common chronic mental disorder, and it also can cause depressive symptoms and cognitive impairment. The primary aim of this study was to determine whether inflow-frequency transcranial magnetic stimulation (ILF-TMS) improves anxiety symptoms in patients with GAD. Methods: Sixty-two patients with GAD were randomly divided into 2 groups. Thirty-one patients in the active ILF-TMS group and 31 patients in the sham ILF-TMS group. All participants were assessed at baseline, week 2, week 4 and week 12. The intention-to-treat methodology was used for the analysis. Results: The response rate was higher in the active group than in the sham group, with a significant difference at week 12 (response rate: 80.6% vs. 54.8%, respectively; P = 0.03). Although the remission rate was higher in the active group at week 12, there was no statistically significant difference between the groups (remission rate: 71.0% vs. 48.4%; P > 0.05). No statistically significant differences on the Hamilton Depression Rating Scale, Clinical Global Impression scale, and neurocognitive test between groups were observed (overall P > 0.05). Adverse events that occurred in the active group were similar to those in the sham group, with no significant differences (P > 0.05). Conclusion: The response rate was higher in the active group at the end of the trial, which indicated that ILF-TMS may be an effective and safe adjunctive tool to improve anxiety symptoms in patients with GAD.

The high-temperature compressive property of Ti2AlN/TiAl composites, which are promising lightweight materials for high-temperature applications, was investigated. In situ high-energy X-ray diffraction (HEXRD) was utilized to analyze the micromechanical behavior at different deformation stages. It is determined {110}γ fiber texture firstly formed at work hardening stage and {0002}H fiber texture appeared at softening stage. The micro-deformation sequences were related to crystallographic orientations where [200]//LD, [202]//LD oriented γ grains were easier to work-hardening while [002]//LD, [110]//LD oriented γ grains presented hardening-softening transformation characteristic. The lattice strain wave of [0002]//LD oriented H grain reflected an interesting atomic-scale ripples meanwhile [10_13]//LD oriented H phase presented a unique interface-dislocation mechanism. A significantly higher stress level in H phase demonstrates its strong bearing capacity. Our investigations establish a relationship between macroscopic deformation of composite and the microscopic elastic/plastic deformation of each component meanwhile provide in-depth understanding of the cooperative deformation characteristics in Ti2AlN/TiAl composites.

Although deformation processes in single-phase nano-polycrystalline alloys at different temperatures are well described, the deformation mechanism in two-phase nano-polycrystalline alloys at different temperatures is still unclear. Here, the deformation behaviour of the two-phase TiAl+Ti3Al nano-polycrystalline alloys is investigated at different temperatures by molecular dynamic simulation. For a comprehensive understanding of the processes, mechanical properties of the single-phase TiAl and Ti3Al nano-polycrystalline alloys are explored as well. The results of numerical simulations indicate that temperature has a strong influence on the deformation mechanism of the alloys. When temperature is below 800 K, the critical grain size (~8.3 nm) becomes a dominant factor controlling the deformation process in the single-phase TiAl. In the two-phase TiAl+Ti3Al nano-polycrystalline alloys, the motion of dislocations in the TiAl phase with the grain size smaller than the critical size dominates the deformation process. On the other hand, no obvious phenomena linked with the critical size occur in the Ti3Al phase. Once the strain exceeds 18.0%, the dislocation emission is observed in the Ti3Al grains. At high temperatures (≥800 K), in the two-phase nano-polycrystalline alloy, the deformation mechanism changes from the plastic deformation to the boundary slip and recrystallization.

Background: Whether hepatic resection (HR) could be performed for patients with Barcelona Clinic Liver Cancer (BCLC) B/C stage hepatocellular carcinoma (HCC) is controversial, and the safety and clinical value of HR combined with antiviral therapy for hepatitis B virus (HBV)-related HCC with BCLC-B/C stage remain to be investigated. Methods: We retrospectively evaluated 126 patients with BCLC stage B/C HCC who underwent HR. These patients were divided into the antiviral group (Group A, n = 86) and the control group (Group B, n = 40). The operative indications and prognosis of 126 patients were analyzed. Results: The 1-year, 3-year, and 5-year disease-free survival (DFS) rates for Group A and Group B were 55.4%, 36.1%, 33.7% and 53.8%, 28.2%, 23.1%, respectively. The corresponding overall survival (OS) rates for the two groups were 89.2%, 61.4%, 45.8% and 82.1%, 48.7%, 33.3%, respectively. The DFS and OS for Group A were better than for Group B (p = 0.013, and p = 0.038, respectively). Antiviral therapy was an independent protective factor of late tumor recurrence [hazard ratio (HR) = 0.391, 95% confidence interval (CI): 0.190–0.806, p = 0.011] but not of early tumor recurrence. Conclusion: It is safe and feasible to perform HR combined with antiviral therapy for HBV-related HCC with BCLC stage B/C.