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19 results on '"William R. Wagner"'

1. Can a Biohybrid Patch Salvage Ventricular Function at a Late Time Point in the Post-Infarction Remodeling Process?

Author

Lindemberg M. Silveira-Filho, MD, PhD, Garrett N. Coyan, MD, MS, Arianna Adamo, MS, Samuel K. Luketich, MS, Giorgio Menallo, BSc, MSc, Antonio D’Amore, PhD, and William R. Wagner, PhD

Subjects
biomaterial, cardiac patch, left ventricular remodeling, myocardial infarction, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Summary: A biohybrid patch without cellular components was implanted over large infarcted areas in severely dilated hearts. Nonpatched animals were assigned to control or losartan therapy. Patch-implanted animals responded with better morphological and functional echocardiographic endpoints, which were more evident in a subgroup of animals with very low pre-treatment ejection fraction (

Published
2021
Full Text
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2. An Elastomeric Polymer Matrix, PEUU-Tac, Delivers Bioactive Tacrolimus Transdurally to the CNS in Rat

Author

Yolandi van der Merwe, Anne E. Faust, Ian Conner, Xinzhu Gu, Firuz Feturi, Wenchen Zhao, Bianca Leonard, Souvik Roy, Vijay S. Gorantla, Raman Venkataramanan, Kia M. Washington, William R. Wagner, and Michael B. Steketee

Subjects
Tacrolimus, FK506, Retinal ganglion cell, CNS, Axon regeneration, Optic nerve, Medicine, Medicine (General), R5-920
Abstract

Central nervous system (CNS) neurons fail to regrow injured axons, often resulting in permanently lost neurologic function. Tacrolimus is an FDA-approved immunosuppressive drug with known neuroprotective and neuroregenerative properties in the CNS. However, tacrolimus is typically administered systemically and blood levels required to effectively treat CNS injuries can lead to lethal, off-target organ toxicity. Thus, delivering tacrolimus locally to CNS tissues may provide therapeutic control over tacrolimus levels in CNS tissues while minimizing off-target toxicity. Herein we show an electrospun poly(ester urethane) urea and tacrolimus elastomeric matrix (PEUU-Tac) can deliver tacrolimus trans-durally to CNS tissues. In an acute CNS ischemia model in rat, the optic nerve (ON) was clamped for 10s and then PEUU-Tac was used as an ON wrap and sutured around the injury site. Tacrolimus was detected in PEUU-Tac wrapped ONs at 24 h and 14 days, without significant increases in tacrolimus blood levels. Similar to systemically administered tacrolimus, PEUU-Tac locally decreased glial fibrillary acidic protein (GFAP) at the injury site and increased growth associated protein-43 (GAP-43) expression in ischemic ONs from the globe to the chiasm, consistent with decreased astrogliosis and increased retinal ganglion cell (RGC) axon growth signaling pathways. These initial results suggest PEUU-Tac is a biocompatible elastic matrix that delivers bioactive tacrolimus trans-durally to CNS tissues without significantly increasing tacrolimus blood levels and off-target toxicity.

Published
2017
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3. Can a Biohybrid Patch Salvage Ventricular Function at a Late Time Point in the Post-Infarction Remodeling Process?

Author

Giorgio Menallo, Antonio D'Amore, Arianna Adamo, Garrett N. Coyan, Lindemberg M. Silveira-Filho, William R. Wagner, and Samuel K. Luketich

Subjects
0301 basic medicine, PECUU, poly(ester carbonate urethane) urea, LVsd, left ventricular end-systolic diameter, 030204 cardiovascular system & hematology, HF, heart failure, 0302 clinical medicine, LVEF, left ventricular ejection fraction, Myocardial infarction, EDA, end-diastolic area, cardiac patch, left ventricular remodeling, Ejection fraction, Ventricular function, FS, fractional shortening, biomaterial, ECM, extracellular matrix, Losartan, myocardial infarction, LVdd, left ventricular end-diastolic diameter, Cardiology, MI, myocardial infarction, cardiovascular system, SMA, smooth muscle actin, Cardiology and Cardiovascular Medicine, medicine.drug, medicine.medical_specialty, PBS, phosphate-buffered saline, 03 medical and health sciences, MT, Masson trichrome, Internal medicine, ESA, end-systolic area, PEUU, poly(ester urethane) urea, medicine, EF, ejection fraction, Diseases of the circulatory (Cardiovascular) system, Time point, Ventricular remodeling, Process (anatomy), Post infarction, business.industry, medicine.disease, AT1R, angiotensin 1 receptor, 030104 developmental biology, LV, left ventricle, M2, macrophage type 2, RC666-701, M1, macrophage type 1, Preclinical Research, LVFW, left ventricular free wall, business
Abstract

Visual Abstract, Highlights • A simple, biohybrid patch made of polymer (PECUU) and ECM, without cellular components, was able to induce positive remodeling features when applied over chronic infarcts with severely dilated hearts and high cardiac function impairment in rats. • The remodeling benefit was particularly notable in a subgroup of the sickest rats with very low initial ejection fraction in which the echocardiographic endpoints were found to improve after treatment. • This technological approach may hold promise for future translation to patients in a chronic scenario., Summary A biohybrid patch without cellular components was implanted over large infarcted areas in severely dilated hearts. Nonpatched animals were assigned to control or losartan therapy. Patch-implanted animals responded with better morphological and functional echocardiographic endpoints, which were more evident in a subgroup of animals with very low pre-treatment ejection fraction (

Published
2021

4. Preface

Author

William R. Wagner, Shelly E. Sakiyama-Elbert, Guigen Zhang, Michael J. Yaszemski, Buddy D. Ratner, Allan S. Hoffman, Frederick J. Schoen, and Jack E. Lemons

Published
2020

6. Introduction

Author

Buddy D. Ratner and William R. Wagner

Published
2020

7. List of Contributors

Author

Abhinav Acharya, Marian A. Ackun-Farmmer, John R. Aggas, Phillip J. Andersen, James M. Anderson, Kristi Anseth, Paul A. Archer, Nureddin Ashammakhi, Jose D. Avila, Julia E. Babensee, Stephen f. Badylak, Kiheon Baek, Aaron B. Baker, Syeda Mahwish Bakht, Amit Bandyopadhyay, Aaron Barchowsky, Garrett Bass, Matthew L. Becker, Sarah Miho Van Belleghem, Danielle S.W. Benoit, Arne Biesiekierski, Kristen L. Billiar, Susmita Bose, Christopher Bowman, Steven Boyce, Bryan N. Brown, Justin L. Brown, Jeffrey R. Capadona, David G. Castner, Calvin Chang, Philip Chang, Ashutosh Chilkoti, Karen L. Christman, Sangwon Chung, Kelly P. Coleman, Dan Conway, Keith E. Cook, Stuart L. Cooper, Elizabeth Cosgriff-Hernandez, Arthur J. Coury, Joseph D. Criscione, Heidi Culver, Jim Curtis, Feiyang Deng, Prachi Dhavalikar, Luis Diaz-Gomez, Rui M.A. Domingues, Elaine Duncan, Pamela Duran, Pedro Esbrit, Suzanne G. Eskin, Michael Y. Esmail, Jack L. Ferracane, Claudia Fischbach, Gary Fischman, John P. Fisher, Iolanda Francolini, Steven J. Frey, Akhilesh K. Gaharwar, Andrés J. García, Iain R. Gibson, Jeremy L. Gilbert, Brian Ginn, Zachary E. Goldblatt, Seth J. Goldenberg, Manuela E. Gomes, Manuel Gómez-Florit, Inês C. Gonçalves, Maud B. Gorbet, David W. Grainger, Miles Grody, Teja Guda, Scott A. Guelcher, Anthony Guiseppi-Elie, S. Adam Hacking, Nadim James Hallab, Luanne Hall-Stoodley, Stephen R. Hanson, Woojin M. Han, Melinda K. Harman, Roger Harrington, Martin J. Haschak, Daniel E. Heath, Emily Anne Hicks, Ryan T. Hill, Allan S. Hoffman, Thomas A. Horbett, Jeffrey A. Hubbell, Rasim Ipek, Joshua J. Jacobs, Young C. Jang, Shaoyi Jiang, Richard J. Johnson, Julian R. Jones, Vickie Y. Jo, Ravi S. Kane, David L. Kaplan, Ronit Kar, Benjamin George Keselowsky, Ali Khademhosseini, Yu Seon Kim, Martin W. King, Daniel S. Kohane, David H. Kohn, Liisa T. Kuhn, Mangesh Kulkarni, Catherine K. Kuo, Angela Lai, Bryron Lambert, Ziyang Lan, Robert A. Latour, Cato T. Laurencin, Bryan K. Lawson, Shannon Lee Layland, Jae Sung Lee, David Lee-Parritz, Ying Lei, Jack E. Lemons, Robert J. Levy, Gregory M. Lewerenz, Jamal S. Lewis, Simone Liebscher, Chien-Chi Lin, Natalie K. Livingston, Yang Li, Yuncang Li, Helen Lu, Laura Macdougall, Bhushan Mahadik, Sachin Mamidwar, Margaret P. Manspeaker, Hai-Quan Mao, Peter X. Ma, Tyler Marcet, Jeffrey Martin, M. Cristina L. Martins, Sally L. McArthur, Meghan McGill, Larry V. McIntire, Lei Mei, Bárbara B. Mendes, Antonios G. Mikos, Richard N. Mitchell, Indranath Mitra, Ben Muirhead, Khurram Munir, William L. Murphy, Phong K. Nguyen, Alexis L. Nolfi, Clyde Overby, Sertan Ozan, Robert F. Padera, Hannah A. Pearce, Nicholas A. Peppas, Andreia T. Pereira, Carmem S. Pfeifer, Artur M. Pinto, Nicole R. Raia, Edward A. Rankin, Buddy D. Ratner, Maria Vallet Regi, Rui L. Reis, Alastair Campbell Ritchie, Shelly E. Sakiyama-Elbert, Karim Salhadar, Antonio J. Salinas, Katja Schenke-Layland, Frederick J. Schoen, Brittany E. Schutrum, Michael V. Sefton, Michael A. Seidman, Darshan S. Shah, Heather Sheardown, Andrew J. Shoffstall, Carl G. Simon, Josh Simon, Kenneth R. Sims Jr., Steven M. Slack, Benjamin Slavin, Kirstie Lane Snodderly, Patrick S. Stayton, Stephanie D. Steichen, Paul Stoodley, W. Benton Swanson, Hobey Tam, Aftab Tayab, Susan N. Thomas, Kellen D. Traxel, Rocky S. Tuan, Erik I. Tucker, Rei Ukita, Austin Veith, Sarah E. Vidal Yucha, Christopher Viney, Naren Vyavahare, William R. Wagner, Min Wang, Raymond M. Wang, Petra Warner, Cuie Wen, Jennifer L. West, Matthew A. Whitman, Frank Witte, Michael F. Wolf, Zhicheng Yao, Michael Yaszemski, Michael J. Yaszemski, Lichen Yin, Guigen Zhang, Peng Zhang, Zhiyuan Zhong, and Nicholas P. Ziats

Published
2020

8. Introduction to Biomaterials Science

Author

Jack E. Lemons, Shelly E. Sakiyama-Elbert, Guigen Zhang, Buddy D. Ratner, William R. Wagner, Frederick J. Schoen, Michael J. Yaszemski, and Allan S. Hoffman

Subjects
Materials science
Published
2020

11. An Elastomeric Polymer Matrix, PEUU-Tac, Delivers Bioactive Tacrolimus Transdurally to the CNS in Rat

Author

Xinzhu Gu, Souvik Roy, Ian P. Conner, Yolandi van der Merwe, Wenchen Zhao, Michael B. Steketee, Kia M. Washington, Bianca T. Leonard, Anne E. Faust, Raman Venkataramanan, William R. Wagner, Vijay S. Gorantla, and Firuz G. Feturi

Subjects
Central Nervous System, Retinal Ganglion Cells, 0301 basic medicine, Optic nerve, Polyesters, medicine.medical_treatment, Central nervous system, FK506, Ischemia, lcsh:Medicine, chemical and pharmacologic phenomena, Pharmacology, Neuroprotection, General Biochemistry, Genetics and Molecular Biology, Tacrolimus, 03 medical and health sciences, Drug Delivery Systems, 0302 clinical medicine, medicine, Animals, Humans, Retinal ganglion cell, Axon regeneration, lcsh:R5-920, Glial fibrillary acidic protein, biology, business.industry, lcsh:R, General Medicine, medicine.disease, Rats, 3. Good health, Astrogliosis, 030104 developmental biology, Immunosuppressive drug, medicine.anatomical_structure, surgical procedures, operative, Elastomers, Optic Nerve Injuries, Anesthesia, Toxicity, biology.protein, CNS, business, lcsh:Medicine (General), 030217 neurology & neurosurgery, Research Paper
Abstract

Central nervous system (CNS) neurons fail to regrow injured axons, often resulting in permanently lost neurologic function. Tacrolimus is an FDA-approved immunosuppressive drug with known neuroprotective and neuroregenerative properties in the CNS. However, tacrolimus is typically administered systemically and blood levels required to effectively treat CNS injuries can lead to lethal, off-target organ toxicity. Thus, delivering tacrolimus locally to CNS tissues may provide therapeutic control over tacrolimus levels in CNS tissues while minimizing off-target toxicity. Herein we show an electrospun poly(ester urethane) urea and tacrolimus elastomeric matrix (PEUU-Tac) can deliver tacrolimus trans-durally to CNS tissues. In an acute CNS ischemia model in rat, the optic nerve (ON) was clamped for 10s and then PEUU-Tac was used as an ON wrap and sutured around the injury site. Tacrolimus was detected in PEUU-Tac wrapped ONs at 24 h and 14 days, without significant increases in tacrolimus blood levels. Similar to systemically administered tacrolimus, PEUU-Tac locally decreased glial fibrillary acidic protein (GFAP) at the injury site and increased growth associated protein-43 (GAP-43) expression in ischemic ONs from the globe to the chiasm, consistent with decreased astrogliosis and increased retinal ganglion cell (RGC) axon growth signaling pathways. These initial results suggest PEUU-Tac is a biocompatible elastic matrix that delivers bioactive tacrolimus trans-durally to CNS tissues without significantly increasing tacrolimus blood levels and off-target toxicity., Highlights • PEUU-Tac locally delivers tacrolimus to CNS tissues • PEUU-Tac positively modulates CNS tissue remodeling • PEUU-Tac minimizes off-target tacrolimus toxicity Central nervous system (CNS) injury typically results in permanently lost neurological function. Tacrolimus is an FDA-approved drug used during organ transplantation that also has CNS neuroprotective and neuroregenerative properties. However, tacrolimus is typically delivered systemically in the blood and delivering effective concentrations to CNS tissues requires tacrolimus blood levels that can lead to adverse side effects in multiple organs. Herein we show that PEUU-Tac, a tacrolimus-eluting matrix, can locally deliver tacrolimus to injured CNS tissues without increasing blood levels, suggesting PEUU-Tac can be used to treat CNS injuries locally while minimizing adverse side effects.

Published
2017

12. Design Principles in Biomaterials and Scaffolds

Author

William R. Wagner and Yang Zhu

Subjects
Scaffold, Engineering, business.industry, Systems engineering, Design elements and principles, business, Design for manufacturability
Abstract

This chapter introduces general design principles in biomaterials and scaffolds. Previous experiences and selected advances are summarized according to considerations to be taken in scaffold designs to meet the two basic requirements for practicality: efficacy and safety. The manufacturability of scaffolds is also briefly discussed. As limited by the volume of the text, only major aspects in the two categories are covered in this chapter. Readers are welcome to refer to other chapters in this book for more detailed and comprehensive information.

Published
2019

13. Attendees at Chengdu Definitions in Biomaterials Conference 2019

Author

Brendan A.C. Harley, Ki Dong Park, Arthur J. Coury, Joachim Kohn, Jiandong Ding, Kazunori Kataoka, Yuliang Zhao, Kai Zhang, Guoping Chen, Frank Witte, Madoka Takai, Hanry Yu, Andrés J. García, Yingjun Wang, Xingdong Zhang, Keith M. McLean, Wei Sun, Carl G. Simon, Ruggero Bettini, Seeram Ramakrishna, Serena M. Best, Changsheng Liu, Jiang Chang, Jian Ji, Jui-Che Lin, Rena Bizios, Maria J. Vicent, Timmie Topoleski, John L. Brash, Nicholas A. Peppas, Yilin Cao, Laura A. Poole-Warren, Helen H. Lu, Peter X. Ma, John A. M. Ramshaw, Ling Qin, James T. Anderson, Elizabeth Cosgriff-Hernandez, Kristi S. Anseth, Yasuhiko Tabata, Cato T. Laurencin, Mário A. Barbosa, William R. Wagner, Tingfei Xi, Xiaobing Fu, Iulian Vasile Antoniac, David F. Williams, Rui L. Reis, Deon Bezuidenhout, Hua Ai, Bikramjit Basu, Yunbing Wang, and Kam W. Leong

Subjects
Engineering, business.industry, 0206 medical engineering, 02 engineering and technology, 021001 nanoscience & nanotechnology, 0210 nano-technology, business, 020601 biomedical engineering
Published
2019

14. Contributors

Author

Rachit Agarwal, Jon D. Ahlstrom, Rafiq Ahmad, Emilio I. Alarcon, Alejandro J. Almarza, Graça Almeida-Porada, Manuel Almeida, Melissa Alvarado-Velez, James M. Anderson, Judith Arcidiacono, Anthony Atala, Stephen F. Badylak, Wayne Balkan, Brian G. Ballios, Pedro M. Baptista, M. Douglas Baumann, Supinder S. Bedi, Ravi V. Bellamkonda, Nicole M. Bergmann, Helen M. Blau, Joel D. Boerckel, Andres M. Bratt-Leal, James C. Brown, Scott Brubaker, Isabelle Brunette, Gisele A. Calderon, Arnold I. Caplan, David G. Castner, Cynthia Chang, Aditya Chawla, Xuguang Chen, Paul Cohen, Michael J. Cooke, Joshua S. Copus, Vitor M. Correlo, Charles S. Cox, Abritee Dahl, Richard M. Day, Paolo De Coppi, Mahesh C. Dodla, Jennifer H. Elisseeff, Juliet A. Emamaullee, Adam Esa, Yunlan Fang, Heather J. Faust, John P. Fisher, Matthew B. Fisher, Elvis L. Francois, Andrés J. García, Svetlana Gavrilov, Dan Gazit, Zulma Gazit, Christopher V. Gemmiti, Gregory J. Gillispie, Sarah E. Gilpin, W.T. Godbey, Andrea Gray, Ronald M. Green, May Griffith, Robert E. Guldberg, Qiongyu Guo, Geoffrey C. Gurtner, Michael C. Hacker, Issa A. Hanna, Joshua M. Hare, Konstantinos E. Hatzistergos, Ralf-Peter Herber, Jöns Hilborn, H. David Humes, Joshua G. Hunsberger, Kenjiro Iwasa, John D. Jackson, Margaret L. Jackson, Hae Lin Jang, John A. Jansen, Josephine Johnston, Carl Jorns, Huijun Kang, David L. Kaplan, David S. Kaplan, Adam J. Katz, Matthew W. Kelley, Kelsey Kennedy, Ali Khademhosseini, Gilson Khang, Jinho Kim, Rachel H. Klein, Irina Klimanskaya, Paul S. Knoepfler, In Kap Ko, Yash M. Kolambkar, Jan Krieghoff, Nathan W. Kucko, Manoj Kumar, Joanne Kurtzberg, Anna Kwilas, Donald W. Landry, Mark T. Langhans, Robert Lanza, Giacomo Lanzoni, Sang Jin Lee, Sander C.G. Leeuwenburgh, Kam W. Leong, Rui Liang, Volha Liaudanskaya, Hang Lin, Michael T. Longaker, Hermann P. Lorenz, Jeanne F. Loring, Shi-Jiang Lu, Alberto Lue, Peter X. Ma, Renata S. Magalhaes, Serena Mandla, Clement D. Marshall, Manuela Martins-Green, Devon E. Mason, Jonquil R. Mau, Richard McFarland, Melissa K. McHale, James C. Melville, Jason R. Meyers, Antonios G. Mikos, Jordan S. Miller, Paul A. Mittermiller, Hideki Miyachi, Shinka Miyamoto, Nelson Monteiro, Alessandra L. Moore, Sara Morini, Philipp T. Moser, Vivek J. Mukhatyar, Mark Murdock, Aaron Nagiel, Gail K. Naughton, Allison Nauta, Javier Navarro, Jared M. Newton, Aparna Nori, Teruo Okano, Joaquim M. Oliveira, Harald C. Ott, Jagannath Padmanabhan, Kristin M. Page, Anil Kumar Pallickaveedu Rajan Asari, Virginia E. Papaioannou, Jihoon Park, Samantha L. Payne, Gadi Pelled, Andrew Pepper, Elumalai Perumal, Melissa Petreaca, Christopher J. Pino, Alessandro Pirosa, Iris Pla-Palacín, Marta Pokrywczynska, Christopher D. Porada, Blaise D. Porter, Milica Radisic, Kunal J. Rambhia, F. Raquel Maia, Buddy D. Ratner, A.H. Reddi, Rui L. Reis, Laura Ricles, Camillo Ricordi, Muhammad Rizwan, Rebecca Robinson, Melanie Rodrigues, Benjamin B. Rothrauff, Hooman Sadri-Ardekani, Pilar Sainz-Arnal, Rangarajan Sambathkumar, Natalia Sánchez-Romero, Michelle Scarritt, Christopher M. Schneider, Steven D. Schwartz, Sarah Selem, Trinidad Serrano-Aulló, A.M. James Shapiro, Dmitriy Sheyn, Tatsuya Shimizu, Toshiharu Shinoka, Molly S. Shoichet, Toshihiro Shoji, Thomas Shupe, Andrew G. Sikora, Fiona Simpson, Aleksander Skardal, Daniel Skuk, Brandon T. Smith, Jihee Sohn, Shay Soker, Estela Solanas, Jeong Eun Song, Disha Sood, David L. Stocum, Stephen C. Strom, Jessica M. Sun, Hironobu Takahashi, Jacques P. Tremblay, Nirmalya Tripathy, John W. Tse, Rocky S. Tuan, Catherine M. Verfaillie, Gordana Vunjak-Novakovic, William R. Wagner, Yanling Wang, Emma Watson, Jennifer L. West, David F. Williams, James K. Williams, Mark E. Wong, Savio L-Y. Woo, Fiona M. Wood, Lei Xu, Doron C. Yakubovich, Yafeng Yang, Michael J. Yaszemski, Pamela C. Yelick, Evelyn K.F. Yim, Carolyn Yong, James J. Yoo, Simon Young, Nora Yucel, Rachel L. Zacharias, Yuanyuan Zhang, Ai Zhang, Jin Zhang, and Yang Zhu

Published
2018

15. Contributors

Author

Sascha Abramson, D. Michael Ackermann, Robert Akins, Richard Anders, Phillip J. Andersen, James M. Anderson, James A. Ankrum, Kristi S. Anseth, Joe Antonucci, Sarah Atzet, Stephen F. Badylak, Gail D. Baura, Ravi V. Bellamkonda, Serena M. Best, Sarindr Bhumiratana, Richard W. Bianco, Jack C. Bokros, Harvey S. Borovetz, Adele L. Boskey, Justin L. Brown, Bryan N. Brown, Stanley A. Brown, John B. Brunski, Fred Cahn, Alastair Campbell Ritchie, Arnold I. Caplan, Richard L. Carpenedo, Ashutosh Chilkoti, Sangwon Chung, Elisa Cimetta, Gary Cleary, Isaac P. Clements, André Colas, Kelly P. Coleman, Daniel E. Conway, Stuart L. Cooper, Bill Costerton, Arthur J. Coury, Crystal Cunanan, Jim Curtis, Antonio D’Amore, Patrick DeMeo, Tejal A. Desai, Sabine Dickens, Gonzalo Domingo, Elaine Duncan, Suzanne G. Eskin, David W. Feigal, Lino Ferreira, Jason Fuller, Robert P. Gallegos, Ellen Gawalt, Kaustabh Ghosh, Bilal Ghosn, Thomas W. Gilbert, Drew Elizabeth Glaser, Amandine Godier-Furnemont, Wayne R. Gombotz, David W. Grainger, Gary L. Grunkemeier, S. Adam Hacking, Nadim James Hallab, Luanne Hall-Stoodley, Stephen R. Hanson, Axel D. Haubold, Kip D. Hauch, Kenneth R. Hawkins, Daniel E. Heath, Douglas L. Helm, Larry L. Hench, Arne Hensten, Ryan T. Hill, Christopher Hobson, Simon P. Hoerstrup, Allan S. Hoffman, Thomas A. Horbett, Jeffrey A. Hubbell, Mark S. Humayun, Ray Ideker, Donald E. Ingber, Rakhi Jain, Jean Jacob, Joshua James Jacobs, Nils Jacobsen, Ruyun Jin, Richard J. Johnson, Jeffrey M. Karp, F. Kurtis Kasper, Sandeep Kathju, Ali Khademhosseini, Sungwon Kim, Martin W. King, Lothar W. Kleiner, Joachim Kohn, Heidi E. Koschwanez, Sangamesh G. Kumbar, Catherine K. Kuo, Lisa LaFleur, Matthew T. Lahti, Byron Lambert, Robert Langer, Cato T. Laurencin, David Lee-Parritz, Jack E. Lemons, Mark Levin, Robert J. Levy, Gregory M. Lewerenz, Wan-Ju Li, Chien-Chi Lin, Fang Liu, William G. Lowrie, Ying Lu, Michael J. Lysaght, Robert Maidhof, J.N. Mansbridge, M. Cristina, L. Martins, Jeffrey Martin, Jay P. Mayesh, Todd C. McDevitt, Larry V. McIntire, Katharine Merrit, Claudio Migliaresi, Antonios G. Mikos, Carl E. Misch, Richard N. Mitchell, Robert B. More, Christa W. Moss, Jennifer M. Munson, Melba Navarro, Robert M. Nerem, Rei Ogawa, Britlyn D. Orgill, Dennis P. Orgill, Robert F. Padera, Abhay Pandit, Kinam Park, Anil S. Patel, Roger B. Peck, P. Hunter Peckham, Nicholas A. Peppas, Maria Nunes Pereira, Josep Planell, Ketul C. Popat, Glenn D. Prestwich, Suzie H. Pun, John Rabolt, Roshni S. Rainbow, Taufiek Rajab, Buddy D. Ratner, William M. Reichert, Andrew L. Rivard, Adrian P. Rowley, Gang Ruan, Michael Sacks, Debanjan Sarkar, Sebastian Schaefer, Christine E. Schmidt, Frederick J. Schoen, Stacey C. Schutte, Michael V. Sefton, Shalaby W. Shalaby, Mark Shirtliff, Marc A. Simon, Milind Singh, Steven M. Slack, Francis A. Spelman, Albert Starr, Patrick S. Stayton, Roger Steinert, Paul Stoodley, Shalu Suri, Thomas Ming Swi Chang, Nina Tandon, Armand R. Tanguay, M. Scott Taylor, Grace S.L. Teo, Charles K. Thodeti, Joshua Tolkoff, Matthew Treiser, Rocky S. Tuan, Erik I. Tucker, Ramakrishna Venugopalan, Angela R. Vicari, Christopher Viney, Jessica M. Voight, Gordana Vunjak-Novakovic, William R. Wagner, Lian Wang, Karen R. Wasiluk, David Christopher Watts, Bernhard H. Weigl, James D. Weiland, John J. Whalen, David F. Williams, Rachel L. Williams, John T. Wilson, Clive G. Wilson, Jessica Winter, Michael F. Wolf, Jeremy C. Wright, Paul Yager, and Weian Zhao

Published
2013

16. Implantable Cardiac Assist Devices and IABPs

Author

Harvey S. Borovetz, Marc A. Simon, and William R. Wagner

Subjects
medicine.medical_specialty, business.industry, Internal medicine, Cardiology, medicine, Cardiac assist, business
Published
2013

17. Contributors

Author

Keith D. Aaronson, Shahab A. Akhter, James F. Antaki, Deborah D. Ascheim, J. Timothy Baldwin, Christian A. Bermudez, Emma J. Birks, Elizabeth D. Blume, Robin Roberts Bostic, Andrew Boyle, Eric A. Chen, Walter Dembitsky, Mary Amanda Dew, Annetine C. Gelijns, Theresa Gelzinis, Eiran Z. Gorodeski, Kathleen L. Grady, Igor Gregoric, Jennifer L. Hall, J. Thomas Heywood, William L. Holman, Tina Ommaya Ivovic, Brian Jaski, Valluvan Jeevanandam, Ranjit John, Francesca Joseph, Robert L. Kormos, Kathleen L. Lockard, Donna Mancini, Leslie W. Miller, Alan Moskowitz, Yoshifumi Naka, Francis D. Pagani, Michael K. Parides, Sonna M. Patel-Raman, Marc S. Penn, Shradha Rathi, Joseph G. Rogers, Stuart D. Russell, Mark S. Slaughter, Randall C. Starling, Lynne Warner Stevenson, Jeffrey Teuteberg, Guillermo Torre-Amione, William R. Wagner, Richard K. Wampler, John T. Watson, Peter D. Wearden, Joshua R. Woolley, and James B. Young

Published
2012

19. Application of Materials in Medicine, Biology, and Artificial Organs

Author

Jack E. Lemons, Nadim J. Hallab, Dennis C. Smith, Harvey S. Borovetz, Jeffery R. Morgan, Allan S. Hoffman, Joshua J. Jacobs, A. Norman Cranin, Paul Yager, Paul S. Malchesky, Andre Rudolf Louis Colas, Robert E. Padera, J. Lawrence Katz, John F. Burke, Bartley P. Griffith, Michael V. Sefton, Ray Ideker, Robert T. Sheridan, Jack Kennedy, Peter J. Tarcha, Thomas E. Rohr, William R. Wagner, Thomas Ming Swi Chang, Ramakrishna Venugopalan, Cynthia H. Gemmell, Francis A. Spelman, Ronald G. Tomapkins, Miguel F. Reffojo, Frederick J. Schoen, Mark S. Roby, Jim Curtis, Anil S. Patel, Martin L. Yarmush, and Jorge Heller

Subjects
Physiology, Computational biology, Biology
Published
1996

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