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Start Over Author "Wiggs, Janey L." Publisher elsevier
38 results on '"Wiggs, Janey L."'

2. List of contributors

Author

Ahmad, Hanif, primary, Alany, Raid G., additional, Alió, Jorge L., additional, Anderson, Andrew J., additional, Arora, Anmol, additional, Azuara-Blanco, Augusto, additional, Barrio, Jorge Alio del, additional, Baudouin, Christophe, additional, Bou Said, Reeda, additional, Bourne, Rupert R.A., additional, Butt, Fatima, additional, Calkins, David J., additional, Chan, Geoffrey Z.P., additional, Cheng, Ching-Yu, additional, Chong, Rachel S., additional, Cordeiro, Maria Francesca, additional, Crowston, Jonathan G., additional, Daka, Qëndresë, additional, Daneshvar, Ramin, additional, Denniss, Jonathan, additional, Deol, Sundeep Singh, additional, Epstein, Rebecca, additional, Ertel, Monica, additional, Fam, Jonathan M., additional, Fellman, Ronald L., additional, Garway-Heath, Ted, additional, Gazzard, Gus, additional, Gilbert, Clare, additional, Gillmann, Kevin, additional, Goldberg, Ivan, additional, Goldberg, Jeffrey L., additional, Grover, Sumit, additional, Heatley, Gregg A., additional, Hoffmann M., Esther, additional, Huang, Alex S., additional, Jin, Zi-Bing, additional, Johnstone, Murray, additional, Kahook, Malik, additional, Katz, L. Jay, additional, Kaufman, Paul L., additional, Keane, Pearse A., additional, Khawaja, Anthony P., additional, Khoueir, Ziad, additional, Lawlor, Mitchell, additional, Leung, Christopher, additional, Malyugin, Boris, additional, Mansberger, Steven L., additional, Mansouri, Kaweh, additional, Martin, Keith R., additional, Martinez, Christine E., additional, McKendrick, Allison M., additional, Mermoud, André, additional, Nickells, Robert W., additional, Nouri-Mahdavi, Kouros, additional, Oostra, Tyler D., additional, Palko, Joel, additional, Patel, Radhika Pooja, additional, Pradhan, Zia S., additional, Priyanka, Ramesh, additional, Rao, Harsha L., additional, Razeghinejad, Reza, additional, Realini, Tony, additional, Ritch, Robert, additional, Roy, Sylvain, additional, Sailer, Kerstin, additional, Sanchez, Facundo G., additional, Schlötzer-Schrehardt, Ursula, additional, Schuman, Joel S., additional, Scott, Andrew, additional, Seibold, Leonard, additional, Sharma, Anant, additional, Spaeth, George, additional, Strohmaier, Clemens A., additional, Szymanska, Maja, additional, Tanna, Angelo P., additional, Tanuj, Dada, additional, Tapply, Ian H., additional, Tatham, Andrew J., additional, Toris, Carol B., additional, Tsasousis, Konstantinos T., additional, Wang, Ningli, additional, Weinreb, Robert N., additional, Wiggs, Janey L., additional, Wo, Yu Jun, additional, Wollstein, Gadi, additional, Wu, Shen, additional, Wu, Zhichao, additional, Xin, Chen, additional, Yoo, Chungkwon, additional, Young, Cara Capitena, additional, and Zhang, Jingxue, additional

Published
2023
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3. The association between serum lipids and intraocular pressure in two large UK cohorts

Author

Madjedi, Kian M., Stuart, Kelsey V., Chua, Sharon Y.L., Luben, Robert N., Warwick, Alasdair, Pasquale, Louis R., Kang, Jae H., Wiggs, Janey L., Lentjes, Marleen A.H., Aschard, Hugues, Sattar, Naveed, Foster, Paul J., and Khawaja, Anthony P.

Abstract

Purpose: \ud Serum lipids are modifiable, routinely collected blood test features associated with cardiovascular health. We examined the association of commonly collected serum lipid measures (total cholesterol [TC], high-density lipoprotein cholesterol [HDL-C], low-density lipoprotein cholesterol [LDL-C], and triglycerides) with intraocular pressure (IOP).\ud \ud Design: \ud Cross-sectional study in the UK Biobank and European Prospective Investigation into Cancer and Nutrition (EPIC)-Norfolk cohorts.\ud \ud Participants: \ud We included 94 323 participants from the UK Biobank (mean age, 57 years) and 6230 participants from the EPIC-Norfolk (mean age, 68 years) cohorts with data on TC, HDL-C, LDL-C, and triglycerides collected between 2006 and 2009.\ud \ud Methods: \ud Multivariate linear regression adjusting for demographic, lifestyle, anthropometric, medical, and ophthalmic covariables was used to examine the associations of serum lipids with corneal-compensated IOP (IOPcc).\ud \ud Main Outcome Measures: \ud Corneal-compensated IOP.\ud \ud Results: \ud Higher levels of TC, HDL-C, and LDL-C were associated independently with higher IOPcc in both cohorts after adjustment for key demographic, medical, and lifestyle factors. For each 1-standard deviation increase in TC, HDL-C, and LDL-C, IOPcc was higher by 0.09 mmHg (95% confidence interval [CI], 0.06–0.11 mmHg; P < 0.001), 0.11 mmHg (95% CI, 0.08–0.13 mmHg; P < 0.001), and 0.07 mmHg (95% CI, 0.05–0.09 mmHg; P < 0.001), respectively, in the UK Biobank cohort. In the EPIC-Norfolk cohort, each 1-standard deviation increase in TC, HDL-C, and LDL-C was associated with a higher IOPcc by 0.19 mmHg (95% CI, 0.07–0.31 mmHg; P = 0.001), 0.14 mmHg (95% CI, 0.03–0.25 mmHg; P = 0.016), and 0.17 mmHg (95% CI, 0.06–0.29 mmHg; P = 0.003). An inverse association between triglyceride levels and IOP in the UK Biobank (–0.05 mmHg; 95% CI, –0.08 to –0.03; P < 0.001) was not replicated in the EPIC-Norfolk cohort (P = 0.30).\ud \ud Conclusions: \ud Our findings suggest that serum TC, HDL-C, and LDL-C are associated positively with IOP in 2 United Kingdom cohorts and that triglyceride levels may be associated negatively. Future research is required to assess whether these associations are causal in nature.

Published
2022

6. Contributors

Author

Ackerman, Michael J., primary, Ahmed, Minhaz Uddin, additional, Ahn, Sun Hee, additional, Allingham, R. Rand, additional, Alsarraj, Jude, additional, Anderson, Matthew L., additional, Annex, Brian H., additional, Augustine, Christina K., additional, Baranzini, Sergio E., additional, Barnes, Peter J., additional, Beasley, Georgia M., additional, Becker, Richard C., additional, Benjamin, Ivor J., additional, Benson, D. Woodrow, additional, Bentzon, Jacob Fog, additional, Bernard, Philip S., additional, Bertram, Lars, additional, Beskow, Laura M., additional, Bondy, Brigitta, additional, Bos, J. Martijn, additional, Boulting, Gabriella L., additional, Brody, Jerome S., additional, Brown, April S., additional, Buetow, Kenneth H., additional, Bullinger, Lars, additional, Butte, Atul J., additional, Carey, David J., additional, Carlson, George, additional, Chen, David, additional, Chahrour, Maria, additional, Chiocca, E. Antonio, additional, Cho, Alex H., additional, Compton, Carolyn, additional, Cook-Deegan, Robert, additional, Craddock, Nicholas, additional, Coulter, Michael, additional, Damani, Samir B., additional, Danik, Jacqueline S., additional, Dave, Sandeep, additional, Dedrick, Russell, additional, DeLeo, Frank R., additional, Diamandis, Eleftherios P., additional, Dokun, Ayotunde O., additional, Downing, Gregory J., additional, Eck, Stephen L., additional, Edelman, Lucas B., additional, Eggan, Kevin C., additional, Falk, Erling, additional, Faruki, Hawazin, additional, Feng, Junjie, additional, Festen, Eleanora Anna Margaretha, additional, Florez, Jose C., additional, Fowler, Vance G., additional, Freedman, Jennifer A., additional, Freeze, Hudson H., additional, Fröhling, Stefan, additional, Galas, David J., additional, Gerhard, Glenn S., additional, Geschwind, Daniel H., additional, van Kessel, Ad Geurts, additional, Giffin, Robert B., additional, Ginsburg, Geoffrey S., additional, Goodall, Megan, additional, Govender, Praveen, additional, Green, Robert C., additional, Gunter, Chris, additional, Gwinn, Marta, additional, Haga, Susanne B., additional, Heath, James R., additional, Hegele, Robert A., additional, Holton, John, additional, Hood, Leroy, additional, Hunter, Kent W., additional, Hwang, Daehee, additional, Javitt, Gail, additional, Jefferson, Gina, additional, John, Sam, additional, Johnson, Keith J., additional, Johnson, Toby, additional, Joy, Tisha R., additional, Kathiresan, Sekar, additional, Kathuria, Hasmeena, additional, Katwal, Arabindra B., additional, Kawamoto, Kensaku, additional, Kelly, Andrea, additional, Khoury, Muin J., additional, Kim, Jin Woo, additional, Kingsmore, Stephen F., additional, Klingler, Tod, additional, Kobayashi, Scott D., additional, Kohane, Isaac S., additional, Kraus, Virginia Byers, additional, Kuiper, Roland P., additional, Lai-Goldman, Myla, additional, Lamb, Neil E., additional, Lambova, Sevdalina Nikolova, additional, Lanktree, Matthew B., additional, Lawler, Sean E., additional, Ledbetter, David H., additional, Lee, Charles, additional, Lee, Inyoul, additional, Le Roch, Karine G., additional, Levy, Samuel, additional, Limou, Sophie, additional, Liu, Wennuan, additional, Liu, Yutao, additional, London, Barry, additional, MacKeigan, Jeffrey P., additional, Mardis, Elaine R., additional, Marquez, Hector, additional, Marra, Marco, additional, Martin, Christa Lese, additional, Martin, Lisa J., additional, McCarroll, Steven A., additional, McHutchison, John, additional, McLeod, Howard L., additional, Mejías, Asunción, additional, Meltzer, Eric B., additional, Moody, M. Anthony, additional, Morin, Ryan D., additional, Moseley, M. Arthur, additional, Mountain, Joanna L., additional, Müller-Ladner, Ulf, additional, Munroe, Patricia B., additional, Ng, Bobby G., additional, Noble, Paul W., additional, O’Donovan, Michael C., additional, Odunsi, Kunle, additional, Omenn, Gilbert S., additional, Ommen, Steve R., additional, Orlando, Lori A., additional, Osterhaus, Albert D.M.E., additional, Owen, Michael J., additional, Parikshak, Neelroop N., additional, Patel, Keyur, additional, Pavlou, Maria P., additional, Paynter, Nina P., additional, Pejovic, Tanja, additional, Pham, Michael X., additional, Plenge, Robert M., additional, Podgoreanu, Mihai V., additional, Ponts, Nadia, additional, Price, Nathan D., additional, Quinn, Bruce, additional, Quintana, Francisco J., additional, Rader, Daniel J., additional, Ramilo, Octavio, additional, Rehm, Heidi L., additional, Rhodes, Benjamin, additional, Ridker, Paul M., additional, Riggs, Erin Rooney, additional, Ross, Jeffrey S., additional, Rubinstein, Wendy S., additional, Saunders, Carol J., additional, Scott, Joan, additional, Shackel, Nicholas A., additional, Shah, Svati H., additional, Simon, Richard, additional, Sisodiya, Sanjay M., additional, Smits, Saskia L., additional, Stamatoyannopoulos, John A., additional, Steele, Glenn D., additional, Steele, Mark P., additional, Stewart, Tessandra, additional, Thomas, Giovana R., additional, Topol, Eric J., additional, Tunis, Sean R., additional, Turner, Aubrey R., additional, Tyler, Douglas S., additional, Veenstra, David L., additional, Venkatachalam, Ramprasath, additional, Voora, Deepak, additional, Vyse, Timothy J., additional, Walsh, Christopher A., additional, Walsh, Katherine, additional, Wang, Hao, additional, Wang, Jun, additional, Weersma, Rinse K., additional, Weiner, Howard L., additional, Weiss, Scott T., additional, Wester, C. William, additional, Wholley, David N., additional, Wiggs, Janey L., additional, Wijmenga, Cisca, additional, Willard, Huntington F., additional, Williams, Hywel J., additional, Williams, Marc S., additional, Winkler, Cheryl A., additional, Woodcock, Janet, additional, Woods, Christopher W., additional, Wu, Pae C., additional, Xu, Jianfeng, additional, Yee, James, additional, Yoo, Hyuntae, additional, Yu, Timothy, additional, Zhang, Jing, additional, and Zhang, Yurong, additional

Published
2013
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9. Contributors

Author

Ackerman, Michael J., primary, Barnes, Peter J., additional, Becker, Richard, additional, Benjamin, Ivor J., additional, Boguski, Mark, additional, Bondy, Brigitta, additional, Breitbart, Roger E., additional, Brody, Jerome S., additional, Bullinger, Lars, additional, Butte, Atul, additional, Chung, Wendy K., additional, Cottrell, Susan E., additional, Cox, Nancy J., additional, Febbo, Phillip G., additional, Gerhard, Glenn S., additional, Ginsburg, Geoffrey S., additional, Goldstein, David B., additional, Grossman, Iris, additional, Haga, Susanne, additional, Holton, John, additional, Hood, Leroy, additional, Huang, Andrew T., additional, Johnson, Melissa, additional, Khoury, Muin, additional, Lawler, Sean, additional, Lee, Charles, additional, Levy, Samuel, additional, Alfredo Martínez, J., additional, McGrath, Kevin, additional, McHutchison, John, additional, Newby, L. Kristin, additional, Newgard, Christopher, additional, Noble, Paul, additional, Nussbaum, Robert L., additional, Pejovic, Tanya, additional, Plenge, Robert, additional, Quertermous, Thomas, additional, Rader, Daniel J., additional, Ramaswamy, Sridhar, additional, Rimsza, Lisa, additional, Ross, Jeffrey, additional, Shannon, M. Frances, additional, Shianna, Kevin, additional, Singleton, Andrew, additional, Snyderman, Ralph, additional, Stewart, Alison, additional, Thomas, Giovana, additional, Topol, Eric J., additional, Towbin, Jeffrey A., additional, Veenstra, Timothy D., additional, Veenstra, David L., additional, Weiner, Howard L., additional, Weiss, Scott T., additional, Wiesner, Georgia, additional, Wiggs, Janey L., additional, Wijmenga, Cisca, additional, Willard, Huntington F., additional, Woodcock, Janet, additional, Woods, Christopher, additional, and Yagil, Yoram, additional

Published
2010
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11. Contributors

Author

Ackerman, Michael J., primary, Anderson, Matthew L., additional, Andreotti, Felicita, additional, Annex, Brian H., additional, Antonellis, Anthony, additional, Artemov, Dmitri, additional, Bain, James R., additional, Barnes, Peter J., additional, Barnholtz-Sloan, J.S., additional, Becker, Richard C., additional, Benjamin, Ivor J., additional, Billings, Paul R., additional, Body, Simon C., additional, Boguski, Mark, additional, Bonassi, Stefano, additional, Bondy, Brigitta, additional, Bos, J. Martijn, additional, Breitbart, Roger E., additional, Brody, Jerome, additional, Brown, Matthew P., additional, Bullinger, Lars, additional, Burgess, Shawn C., additional, Butte, Atul J., additional, Carey, David J., additional, Carlson, George, additional, Celedón, Juan C., additional, Chandrasekharan, Subhashini, additional, Chang, Wing C. (John), additional, Chen, Yan, additional, Chiocca, Antonio, additional, Chow, Theresa Puifun, additional, Chung, Wendy K., additional, Cook-Deegan, Robert, additional, Corella, Dolores, additional, Cottrell, Susan, additional, Cox, Nancy J., additional, Crawford, Nigel P.S., additional, Cuticchia, A. Jamie, additional, Deforce, Dieter, additional, Deng, Mario C., additional, Devi, Gayathri, additional, deVos, Theo, additional, Distler, Juergen, additional, Dohner, Harmut, additional, Dokun, Ayotunde O., additional, Edbrooke, Mark R., additional, Edelman, Lucas B., additional, Elewaut, Dirk, additional, Epstein, Charles J., additional, Fanous, Ayman H., additional, Febbo, Phillip G., additional, Feezor, Robert J., additional, Feng, Yonmei, additional, Földes-Papp, Zeno, additional, Fujinaka, Hidehiko, additional, Galas, David J., additional, Garrison, Louis, P., additional, Gerhard, Glenn S., additional, Ginsburg, Geoffrey S., additional, Gjertsen, Bjorn T., additional, Glass, Michael, additional, Goldstein, David B., additional, Gordon, Erynn S., additional, Gosnell, Tucker, additional, Grass, Peter, additional, Green, Eric D., additional, Grossman, Iris, additional, Gwinn, Marta, additional, Haefliger, Carolina, additional, Haga, Susanne B., additional, Hall, Per, additional, Hare, Joshua M., additional, Hariri, Ahmad, additional, Heath, James R., additional, Hegele, Robert A., additional, Heidecker, Bettina, additional, Hislop, Shona, additional, Hoffman, Eric P., additional, Holton, John, additional, Hood, Leroy, additional, Huang, Andrew T., additional, Huang, Erich S., additional, Hubbard, Carlos A., additional, Hunter, Kent, additional, Hyland, Courtney, additional, Ihm, Chunhwa, additional, Ilkayeva, Olga, additional, Irizarry, Rafael, additional, Jain, Shushant, additional, Johnson, Melissa D., additional, Kantoff, Philip W., additional, Kathiresan, Sekar, additional, Kathuria, Hasmeena, additional, Kawamoto, Kensaku, additional, Keyser, Filip De, additional, Khalid, Asif, additional, Khoury, Muin, additional, Kingsmore, Stephen F., additional, Kittleson, Michelle M., additional, Koshy, Beena T., additional, Krishnan, Ranga, additional, Krouse, Robert S., additional, Kundra, Vikas, additional, Lai-Goldman, Myla, additional, Lakhani, Vipul, additional, Langer, Robert, additional, Lawler, Sean E., additional, Lee, Inyoul, additional, Lee, Charles, additional, Lee, Arthur S., additional, Leong, Stanely, additional, Lesche, Ralf, additional, Levy, Samuel, additional, Liu, Edison T., additional, Lobach, David F., additional, Lorens, James B., additional, Lusis, Aldons J., additional, Lyerly, H. Kim, additional, Madamanchi, Nageswara R., additional, Martinez, J. Alfredo, additional, Masignani, Vega, additional, McGrath, Kevin, additional, McHutchison, John, additional, Middleton, Frank, additional, Mielants, Herman, additional, Muehlbauer, Michael J., additional, Müller-Ladner, Ulf, additional, Nelson, Mark A., additional, Neri, Monica, additional, Netea, Mihai, additional, Newby, L. Kristin, additional, Newgard, Christopher B., additional, Ng, Maggie, additional, Noble, Paul W., additional, Ntziachristos, Vasilis, additional, Nussbaum, Robert L., additional, O'Donoghue, Meghan B., additional, Odunsi, Kunle, additional, Olden, Kenneth, additional, Ommen, Steve R., additional, Ordovas, Jose M., additional, Patarca, Roberto, additional, Patel, Jeetendra, additional, Patel, K., additional, Pato, Carlos N., additional, Pato, Michele T., additional, Pejovic, Tanja, additional, Perin, Noah C., additional, Pham, Michael, additional, Plenge, Robert M., additional, Plum, Achim, additional, Podgoreanu, Mihai V., additional, Pollack, Jonathan R., additional, Pollex, Rebecca L., additional, Price, Nathan D., additional, Quertermous, Thomas, additional, Quintana, Francisco J., additional, Raby, Benjamin A., additional, Rader, Daniel J., additional, Ramaswamy, Sridhar, additional, Rammensee, Hans-Georg, additional, Ramsey, Scott D., additional, Rappuoli, Rino, additional, Rifai, Nader, additional, Rimsza, Lisa, additional, Rogers, Yu-Hui, additional, Roses, Allen D., additional, Ross, Jeffrey S., additional, Roubenoff, Ronenn, additional, Runge, Marschall S., additional, Scheuner, Maren T., additional, Schuster, Matthias, additional, Schwartz, David A., additional, Schwinn, Debra A., additional, Seng, Chia Kee, additional, Shackel, Nicholas A., additional, Shannon, M. Frances, additional, Sherry, A. Dean, additional, Shi, Jiaqi, additional, Shianna, Kevin, additional, Shnayder, Yelizaveta, additional, Singleton, Andrew B., additional, Slavin, T.P., additional, Smith, Desmond J., additional, Snoeckx, Rikkert L., additional, Snyderman, Ralph, additional, Spira, Avrum, additional, Spraggs, Colin F., additional, Stevens, Robert D., additional, Stewart, Nicolas A., additional, Stewart, Alison, additional, Stewart, F., additional, Strausberg, Robert L., additional, Szyf, Moshe, additional, Tan, Weihong, additional, Tepper, Robert I., additional, Tettelin, Hervé, additional, Thomas, Giovana R., additional, Thompson, John D., additional, Thongboonkerd, Visith, additional, Topol, Eric J., additional, Towbin, Jeffrey A., additional, Bodegraven, Ad A. van, additional, Van Den Bogaert, Kris, additional, Van den Bosch, Filip, additional, Vatta, Matte, additional, Veenstra, Timothy D., additional, Veenstra, David L., additional, Vendrov, Aleksandr E., additional, Verfaillie, Catherine M., additional, Walley, Nicole M., additional, Wang, Ling, additional, Weale, Mike, additional, Weinblatt, Michael E., additional, Weiner, Howard L., additional, Weiss, Scott T., additional, Weissleder, Ralph, additional, Wells, Samuel A., additional, Wenner, Brett R., additional, Wiechers, Ilse R., additional, Wiesner, Georgia L., additional, Wiggs, Janey L., additional, Wijmenga, Cisca, additional, Willard, Huntington F., additional, Wilson, James M., additional, Wivel, Nelson A., additional, Wohlgemuth, Jay, additional, Woodcock, Janet, additional, Woods, Christopher W., additional, Woon, Paula W., additional, Yagil, Chana, additional, Yagil, Yoram, additional, Yamamoto, Tadashi, additional, Yao, Gang, additional, Yee, Andrew J., additional, Yoo, Hyuntae, additional, You, Y. Nancy, additional, Yu, Li-Rong, additional, Zagury, Jean-François, additional, Zimmern, Ron, additional, and Züchner, Stephan, additional

Published
2009
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14. List of Contributors

Author

Ahmed, Iqbal ike K., primary, Ahmed, Irma, additional, Ai, Everett, additional, Al-Ghoul, Ahmed, additional, Allen, David, additional, Alvi, Nishat P., additional, Anand, Rajiv, additional, Ang, Leonard P.-K., additional, Apple, David J., additional, Archer, Desmond B., additional, Arnold, Anthony C., additional, Arshinoff, Steve A., additional, Assil, Kerry K., additional, Atebara, Neal H., additional, Atluri, Harvinder K.S., additional, Augsburger, James J., additional, Aylward, G. William, additional, Azar, Dimitri T., additional, Baker, Brad J., additional, Balcer, Laura Joan, additional, Barnett, C.J., additional, Baumal, Caroline R., additional, Bearelly, Srilaxmi, additional, Benson, William E., additional, Berger, Steven Thomas, additional, Biswas, Jyotirmav, additional, Bolling, James P., additional, Bornfeld, Norbert, additional, Bose, Swaraj, additional, Bouchard, Charles S., additional, Boulton, Michael E., additional, Brandt, James D., additional, Brodsky, Michael C., additional, Brown, Kimberly Ellen, additional, Brown, Gary C., additional, Brown, Melissa M., additional, Budenz, Donald L., additional, Bui, Alex, additional, Burns, Stephen K., additional, Campolattaro, Brian N., additional, Cantor, Louis B., additional, Jr, Antonio Capone, additional, Carter, Keith D., additional, Chan, Chi-Chao, additional, Chang, Stanley, additional, Chao, Jennifer R., additional, Charonis, George C., additional, Chew, Paul T.K., additional, Ciardella, Antonio P., additional, Civan, Mortimer M., additional, Clark, Abbott F., additional, Clarke, Jonathan, additional, Contreras, Janice E., additional, Collin, J. Richard O., additional, Codère, François, additional, Corrêa, Zélia M., additional, Cowan, Claude L., additional, Craven, E. Randy, additional, Cruess, Alan F., additional, Custer, Phillip L., additional, Dahan, Elie, additional, Dai, Eric, additional, Damato, Bertil E., additional, Damji, Karim F., additional, Davidson, Richard S., additional, Davis, Elizabeth A., additional, Dhaliwal, Deepinder K., additional, Diamond, Gary R., additional, Do, Diana V., additional, Donahue, Sean P., additional, Dortzbach, Richard K., additional, Drenser, Kimberly A., additional, Duker, Jay S., additional, Dutton, Jonathan J., additional, Edgington, Bryan, additional, Eggers, Howard M., additional, Ehlers, William, additional, Engelbert, Michael, additional, Espandar, Ladan, additional, Evans, Monica, additional, Farjo, Ayad A., additional, Farjo, Qais Anastas, additional, Faucett, Donald C., additional, Feiz, Vahid, additional, Fine, I. Howard, additional, Fisher, Yale L., additional, Fishman, Gerald A., additional, Forster, David J., additional, Fox, Gregory M., additional, Freedman, Jeffrey, additional, Friedman, David S., additional, Friedman, Neil J., additional, Friedman, Deborah I., additional, Fu, Arthur D., additional, Fynn-Thompson, Nicoletta, additional, Ganatra, Jyotsom, additional, Gayre, Gregg S., additional, Gery, Igal, additional, Ghanem, Ramon C., additional, Giblin, Michael, additional, Gigantelli, James W., additional, Goldberg, Anna, additional, Goldberg, Robert A., additional, Goldberg, William, additional, Goldberg, Ivan, additional, Goldstein, Debra A., additional, Goldstein, Michael H., additional, Gonder, John R., additional, Green, Jeffrey P., additional, Greven, Craig M., additional, Gross, Nicole E., additional, Gross, Ronald L., additional, Grover, Sandeep, additional, Guercio, Jason R., additional, Gupta, Vishali, additional, Gupta, Amod, additional, Gurkan, Sevgi, additional, Guthoff, Rudolf E., additional, Hallak, Joelle, additional, Haller, Julia A., additional, Hamilton, Richard S., additional, Harbour, J. William, additional, Hardten, David R., additional, Harris, Alon, additional, Hedges Jr, Thomas R., additional, Heier, Jeffrey S., additional, Henderson, Polly A., additional, Herndon, Leon W., additional, Hitchings, Roger A., additional, Ho, Allen C., additional, Hoffman, Richard S., additional, Holz, Huck A., additional, Howard, Gene R., additional, Howes, Frank W., additional, Hsu, Jason, additional, Hurwitz, Jeffrey J., additional, Inomata, Hajime, additional, Ip, Michael, additional, Isaacs, Robert T., additional, Izak, Andrea M., additional, Jampel, Henry, additional, Jampol, Lee M., additional, Jiyamapa, Julia, additional, Johnson, Chris A., additional, Johnson, T. Mark, additional, Johnson, Mark W., additional, Jones, Nicholas, additional, Kahook, Malik, additional, Kanner, Elliott M., additional, Kapusta, Michael A., additional, Kardon, Randy, additional, Karp, Carol L., additional, Kass, Michael, additional, Katz, L. Jay, additional, Kaufman, Paul L., additional, Khan, Baseer, additional, Khaw, Peng Tee, additional, Kim, Gene, additional, Kimura, Alan E., additional, Kitzmann, Anna, additional, Klancnik, James M., additional, Koch, Douglas D., additional, Kohnen, Thomas, additional, Kojima, Takashi, additional, Kornmehl, Ernest W., additional, Kramarevsky, Natalia, additional, Labbe, Thad, additional, Lane, Stephen S., additional, Lavin, Patrick J.M., additional, Lawton, Andrew, additional, Lee, Paul P., additional, Leen, Martha Motuz, additional, Levinson, Ralph, additional, Lim, Ridia, additional, Lingua, Robert W., additional, Lipham, William J., additional, Lopez, Pedro F., additional, Lundstrom, Mats, additional, Magnante, Peter, additional, Mandava, Naresh, additional, Marak, George E., additional, Marmor, Michael F., additional, Marten, Lisa, additional, Mathura, Jeevan R., additional, Martidis, Adam, additional, Mattox, Cynthia, additional, McDermott, Mark L., additional, McLeod, Stephen D., additional, Mejico, Luis J., additional, Meyers, Sanford M., additional, Mieler, William F., additional, Migdal, Clive S., additional, Miller, David, additional, Miller, Russell, additional, Mimura, Tatsuya, additional, Mittra, Robert A., additional, Moorthy, Ramana S., additional, Morley, Michael G., additional, Morse, Lawrence S., additional, Moshirfar, Majid, additional, Moster, Mark L., additional, Nehls Rikkers, Sarah M., additional, Neff, Ann G., additional, Newlin, Anna C., additional, Noble, Kenneth G., additional, Noecker, Robert J., additional, Okada, Annabelle A., additional, Olson, Jeffrey L., additional, Opalinski, Yvonne A.V., additional, Packer, Mark, additional, Pandey, Suresh K., additional, Patel, Vivek Ravindra, additional, Pavesio, Carlos E., additional, Pineles, Stacy, additional, Piva, Alfio, additional, Piltz-Seymour, Jody, additional, Pollack, John S., additional, Prall, F. Ryan, additional, Price, Marianne O., additional, Price, Francis W., additional, Primack, Jonathan D., additional, Pruett, Ronald C., additional, Puliafito, Carmen A., additional, Pulido, Jose S., additional, Quiros, Peter A., additional, Ramulu, Pradeep, additional, Ramos-Esteban, Jerome C., additional, Rao, P. Kumar, additional, Rao, Narsing A., additional, Read, Russell W., additional, Rechtman, Ehud, additional, Regillo, Carl D., additional, Reichel, Elias, additional, Rhee, Douglas J., additional, Rhee, Steven S., additional, Rheinstrom, Stephen D., additional, Riedel, Patrick J., additional, Rikkers, Sarah M., additional, Robinson, Fiona O., additional, Rodriguez-Coleman, Hannah, additional, Rogers, Adam, additional, Roe, Richard, additional, Roh, Shiyoung, additional, Rosen, Emanuel S., additional, Rosenblatt, Brett, additional, Rosenfeld, Philip J., additional, Rubenstein, Jonathan B., additional, Rubin, Steven E., additional, Rubin, Richard M., additional, Rubsamen, Patrick E., additional, Saadati, Hossein G., additional, Sadun, Alfredo A., additional, Salim, Sarwat, additional, Salinas, Humberto, additional, Samuelson, Thomas W., additional, Sanborn, George E., additional, Sarmiento, Jerome S., additional, Scheufele Cleary, Tina A., additional, Schor, Paulo, additional, Schubert, Hermann D., additional, Schuman, Joel, additional, Schwab, Ivan R., additional, Schwartz, Gary S., additional, Scott, Clifford A., additional, Sebag, Jerry, additional, See, Jovina L.S., additional, Selkin, Robert P., additional, Shields, Bruce, additional, Shingleton, Bradford, additional, Sierra, Patricia B., additional, Sieving, Paul A., additional, Sivalingam, Arunan, additional, Small, Kent W., additional, Smiddy, William E., additional, Soong, Kaz, additional, Soukiasian, Sarkis, additional, Spaide, Richard F., additional, Spoor, Thomas C., additional, Stasi, Kalliopi, additional, Steel, David, additional, Stein, Joshua D., additional, Steinemann, Thomas L., additional, Suchecki, Jeanine, additional, Sugar, Joel, additional, Sugar, Alan, additional, Tan, J.C.H., additional, Tanenbaum, Myron, additional, Taravella, Michael J., additional, Tasman, William S., additional, Telander, David G., additional, Tennant, Matthew T.S., additional, Tessler, Howard H., additional, Thall, Edmond H., additional, Tingey, David P., additional, Tobaigy, Faisal M., additional, Truong, Steven, additional, Tsai, James C., additional, Tsai, Julie, additional, Tsiaras, William G., additional, Tu, Elmer Y., additional, Tucker, Nancy, additional, Tuli, Sonal S., additional, Valluri, Shailaja, additional, Vander, James F., additional, Vaughn, Gregory J., additional, Virasch, Vanee Val, additional, Wadia, Hormuz P., additional, Walker, Rebecca S., additional, Walton, David Sellers, additional, Wang, Li, additional, Wang, Frederick M., additional, Wang, Ming X., additional, Wang, Robert C., additional, Wax, Martin, additional, Weinberg, David V., additional, Weinstein, Joel M., additional, Weiter, John J., additional, Werner, Liliana, additional, Wevill, Mark T., additional, White, Paul F., additional, Wiggs, Janey L., additional, Wilkinson, Charles P., additional, Williams, Patrick D., additional, Williams, George A., additional, Wirostko, William J., additional, Wollstein, Gadi, additional, Yee, Robert D., additional, Young, Joshua A., additional, and Zamir, Ehud, additional

Published
2009
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17. List of Contributors

Author

Abad, Juan-Carlos, primary, Abelson, Mark B, additional, Abramson, David H, additional, Acquadro, Martin A, additional, Adamis, Anthony P, additional, Adams, Wesley H, additional, Afshari, Natalie A, additional, Ai, Everett, additional, Aiello, Lloyd M, additional, Aiello, Lloyd P, additional, Akduman, Levent, additional, Albano, Marissa L, additional, Albert, Daniel M., additional, Alexandrou, Terry J, additional, Alfonso, Eduardo C, additional, Alié, Jorge L, additional, Alizadeh, Hassan, additional, Al Jadaan, Ibrahim A, additional, Al-Jastaneiah, Sabah, additional, Allen, Calliope E, additional, Allen, David, additional, Allen, Robert C, additional, Alm, Albert, additional, Al-Swailem, Samar, additional, Alt, Abigail K, additional, Altaweel, Michael M, additional, Anderson, Russell, additional, Andreoli, Christopher M, additional, Androudi, Sofia, additional, Ang, Leonard PK, additional, Anzaar, Fahd, additional, Apple, David J, additional, Arrigg, Claudia A, additional, Artal, Pablo, additional, Asbell, Penny, additional, Asdourian, George K, additional, Atebara, Neal, additional, Atmaca-Sonmez, Pelin, additional, Audo, Isabelle, additional, Auffarth, Gerd U, additional, Avery, Robin K, additional, Azar, Dimitri T, additional, Baker, Ann S, additional, Balles, Mark, additional, Barnes, Scott D, additional, Barnett, Donald M, additional, Barney, Neal P, additional, Barouch, Fina C, additional, Bartley, George B, additional, Barton, Jason JS, additional, Behlau, Irmgard, additional, Belda, Jose I, additional, Bennett, Jeffrey L, additional, Bennett, Timothy J, additional, Berdy, Gregg J, additional, Bernardino, Carlo Roberto, additional, Bernardino, Vitaliano, additional, Berson, Eliot L, additional, Bharadwaj, Amitabh, additional, Bhisitkul, Robert, additional, Bhui, Ravinder D, additional, Bilyk, Jurij, additional, Biousse, Valérie, additional, Bird, Alan C, additional, Blair, Norman Paul, additional, Blodi, Barbara A, additional, Blumenkranz, Mark S, additional, Boldt, H Culver, additional, Borchert, Mark S, additional, Borrillo, Luigi, additional, Borodic, Gary E, additional, Boruchoff, S Arthur, additional, Bose, Swaraj, additional, Boulton, Michael E, additional, Bowman, RW, additional, Bradley, Elizabeth A, additional, Brazitikos, Periklis D, additional, Breeze, Robert, additional, Bressler, Neil M, additional, Bressler, Susan B, additional, Brini, Alfred, additional, Budenz, Donald L, additional, Buffenn, Angela N, additional, Burk, Scott E, additional, Butrus, Salim, additional, Callanan, David, additional, Cameron, J Douglas, additional, Cantor, Louis B, additional, Cantore, William A, additional, Cantu-Dibildox, Jorge, additional, Casas, Victoria, additional, Casper, Miriam, additional, Casten, Robin J, additional, Catoira, Yara P, additional, Cavallerano, Jerry, additional, Chai, Samantha J, additional, Chalita, Maria R, additional, Chamberlain, Sherman M, additional, Chan, Audrey S, additional, Chan, Chi-Chao, additional, Chan, Paul, additional, Chapin, Matthew J, additional, Chapman, Karen L, additional, Chen, Eric, additional, Chen, Joe, additional, Chen, Julie A, additional, Chen, Teresa C, additional, Chen, Zhou, additional, Chévez-Barrios, Patricia, additional, Chew, Emily Y, additional, Chiang, Mark, additional, Chodosh, James, additional, Chong, Eva-Marie, additional, Chun, Denise, additional, Chylack, Leo T, additional, Ciardella, Antonio P, additional, Civan, Mortimer, additional, Clamen, Liane, additional, Clark, John I, additional, Cockerham, Glenn, additional, Cohen, Andre, additional, Cohen, Elisabeth J, additional, Colby, Kathryn A, additional, Coleman, Anne L, additional, Coleman, Hanna R, additional, Colin, Joseph, additional, Collier, J Michael, additional, Comer, Grant M, additional, Conlon, M Ronan, additional, Cooper, Kim E, additional, Corbett, James J, additional, Coma, Miguel C, additional, Cyrlin, Marshall N, additional, Dagi, Linda R, additional, Dahlgren, Matthew A, additional, Daley, Timothy J, additional, Da Mata, Andrea P, additional, Damato, Bertil, additional, D'Amico, Donald J, additional, Dana, Reza, additional, Danan-Husson, Aude, additional, Danesh-Meyer, Helen B, additional, Danis, Ronald P, additional, Darlington, Jason K, additional, Davidson, Stefanie L, additional, Davis, Janet L, additional, Davis, Elizabeth A, additional, de la Cruz, Jose J, additional, de la Garza, Adam G, additional, DeAngelis, Margaret M, additional, DeMartelaere, Sheri L, additional, Demer, Joseph L, additional, Dhaliwal, Avninder, additional, Dieckert, J Paul, additional, Do, Diana V, additional, Doane, Marshall G, additional, Dodds, Christopher, additional, Dohlman, Claes H, additional, Donati, Guy, additional, Donnenfeld, Eric D, additional, Drack, Arlene, additional, Dryja, Thaddeus P, additional, Dueker, David, additional, Duker, Jay S, additional, Dunbar, Jennifer A, additional, Dunn, James P, additional, Dupps, William J, additional, Durand, Marlene L, additional, Dutton, Jonathan J, additional, Eandi, Chiara M, additional, Edward, Deepak P, additional, Egan, Robert A, additional, Eichenbaum, David A, additional, Eklund, Susan E, additional, Engle, Elizabeth C, additional, Erickson, Kristine, additional, Esmaeli, Bita, additional, Fay, Aaron, additional, Feiner, Leonard, additional, Fekrat, Sharon, additional, Ferris, Frederick L, additional, Fine, Howard F, additional, Fletcher, Donald C, additional, Flikier, Paul, additional, Floyd, Richard P, additional, Flynn, Harry W, additional, Fong, Donald S, additional, Font, Ramon L, additional, Forbes, Brian JR, additional, Foroozan, Rod, additional, Foster, Bradley S, additional, Foster, C Stephen, additional, Foster, Jill A, additional, Foulks, Gary N, additional, Fountain, Tamara R, additional, Fox, Gregory M, additional, Freddo, Thomas F, additional, Freedman, Sharon F, additional, Freund, K Bailey, additional, Friberg, Thomas R, additional, Friedman, Alan H, additional, Friedman, David, additional, Friedman, Deborah I, additional, Friedman, Ephraim, additional, Fu, Arthur D, additional, Fulton, Anne B, additional, Galal, Ahmed, additional, Galetta, Steven, additional, Gallardo, Mark, additional, Gallie, Brenda, additional, Garner, Alec, additional, Garrity, James A, additional, Gatinel, Damien, additional, Gedde, Steven J, additional, Geist, Craig E, additional, Gerber, Steve, additional, Ghanem, Ramon C, additional, Gieser, Jon P, additional, Gilmore, Michael S, additional, Gimbel, Howard V, additional, Gipson, Ilene K, additional, Glover, Tyrone, additional, Goldberg, Robert A, additional, Goldenfeld, Mordechai, additional, Goldstein, Scott M, additional, Gomi, Cintia F, additional, Gong, Haiyan, additional, Gonzales, John A, additional, Goosey, John, additional, Gottlieb, Justin L, additional, Gould, Joshua, additional, Gragoudas, Evangelos S, additional, Granet, David B, additional, Greaney, Michael J, additional, Green, Daniel G, additional, Grehn, Franz, additional, Greiner, Jack V, additional, Greven, Craig M, additional, Griepentrog, Gregory J, additional, Groenewald, Carl, additional, Grosskreutz, Cynthia L, additional, Grover, Lori Latowski, additional, Gullapalli, Vamsi K, additional, Gulur, Padma, additional, Gunther, Jonathan, additional, Gupta, Manish, additional, Gupta, Mayank, additional, Guyer, David R, additional, Haivala, Darin R, additional, Haller, Julia A, additional, Halmagyi, GM, additional, Halperin, Lawrence S, additional, Hamdi, Islam M, additional, Hamilton, Steven R, additional, Hammersmith, Kristin M, additional, Han, Dennis P, additional, Hansen, Ronald M, additional, Harbour, J William, additional, Hariprasad, Seenu M, additional, Harissi-Dagher, Mona, additional, Hassan, Shirin E., additional, Hatton, Mark P, additional, Hawley, Pamela, additional, Hayashida, Yasutaka, additional, Heckenlively, John R, additional, Hedges, Thomas R, additional, Heggie, Alfred D, additional, Heher, Katrinka L, additional, Heier, Jeffrey S, additional, Hejtmancik, J Fielding, additional, Henderson, Bonnie A, additional, Hersh, Peter S, additional, Hidayat, Ahmed A, additional, Higginbotham, Eva Juliet, additional, Hirose, Tatsuo, additional, Ho, Allen C, additional, Ho, ThucAnh T, additional, Hogan, R Nick, additional, Holck, David E, additional, Holekamp, Nancy M, additional, Hovland, Peter G, additional, Hsu, Thomas C, additional, Hsu, William C, additional, Huang, Andrew JW, additional, Hughes, Mark S, additional, Hui, Jennifer, additional, Hunter, David G, additional, Huryn, Laryssa A, additional, Husain, Deeba, additional, Hyndiuk, Robert A, additional, Ip, Michael, additional, Jacobs, Brian J, additional, Jakobiec, Frederick A, additional, Jampol, Lee M, additional, Jensen, Harold G, additional, Ji, Fei, additional, Johnson, David L, additional, Johnson, Douglas H, additional, Johnson, Mark W, additional, Johnson, R Paul, additional, Johnson, Robert N, additional, Joos, Karen M, additional, Joyce, Nancy C, additional, Jumper, J Michael, additional, Jurkunas, Ula V., additional, Kahana, Alon, additional, Kahook, Malik Y, additional, Kanner, Elliott, additional, Kalwerisky, Kevin, additional, Kaplan, Henry J, additional, Karatza, Ekaterini C, additional, Kardon, Randy, additional, Katowitz, James A, additional, Katowitz, William R, additional, Kazlas, Melanie, additional, Keefe, Kelly S, additional, Kelley, Lara, additional, Kent, Charles J, additional, Kenyon, Kenneth R, additional, Khan, Bilal F, additional, Khan, Jemshed A, additional, Khan, Naheed W, additional, Khaw, Peng Tee, additional, Kherani, Femida, additional, Kim, Eva C, additional, Kim, Hee Joon, additional, Kim, Ivana K, additional, Kim, Jonathan W, additional, Kim, Rosa Y, additional, Kim, Stella K, additional, Kim, Tae-Im, additional, Klais, Christina M, additional, Klapper, Stephen R, additional, Klein, Barbara EK, additional, Kleinmann, Guy, additional, Klink, Thomas, additional, Klisovic, Dino D, additional, Klyce, Stephen D, additional, Kocaturk, Tolga, additional, Kohnen, Thomas, additional, Kojima, Takeshi, additional, Koller, Tobias, additional, Kostick, David A, additional, Kraut, Joel A, additional, Krishnan, Chandrasekharan, additional, Krueger, Ronald R, additional, Krug, Joseph H, additional, Krupsky, Sara, additional, Kuchtey, Rachel W, additional, Kurban, Ramsay S, additional, Kurz, Paul A, additional, Kuszak, JR, additional, Kwon, Young H, additional, Labbe, Thad A, additional, Lam, Deborah L, additional, Lamkin, Jeffrey C, additional, Lamping, Kathleen A, additional, Lane, Anne Marie, additional, Lane, Katherine A, additional, Lane, Keith J, additional, Lass, Jonathan H, additional, Lawrence, Mary G, additional, Lee, Andrew G, additional, Lee, Carol M, additional, Lee, Michael S, additional, Lee, Paul P, additional, Lee, William B, additional, Leibovitch, Igal, additional, Lemke, Bradley N, additional, Lemley, Craig A, additional, Leonardi, Andrea, additional, Lessell, Simmons, additional, Levin, Leonard A, additional, Levy-Clarke, Grace A, additional, Lew, Julie C, additional, Lewis, Craig, additional, Li, Wei, additional, Lim, Laurence S, additional, Lim, Lyndell L, additional, Lim, Wee-Kiak, additional, Liu, Grant T, additional, Loewenstein, John I, additional, Lott, McGregor N, additional, Lowry, Jonathan C, additional, Lyon, David B, additional, Lytle, Robert E, additional, MacCumber, Mathew, additional, Mackool, Bonnie T, additional, Madiwale, Nalini A, additional, Mah, Francis, additional, Mainster, Martin A, additional, Manning, Michael H, additional, Mansberger, Steven L, additional, Marc, Robert E, additional, Marchong, Mellone, additional, Marcus, Dennis M, additional, Mares, Julie A, additional, Marr, Brian P, additional, Martinez, Carlos E, additional, Massof, Robert W, additional, Matsumoto, Yukihiro, additional, Mattox, Cynthia, additional, Maus, Marlon, additional, McCabe, Cathleen M, additional, McCormick, Steven A, additional, McCrakken, Michael, additional, McCulley, James P, additional, McDermott, John A, additional, McDonald, H Richard, additional, McDonald, Marguerite B, additional, McDonnell, Peter J, additional, McGillivray, Robert, additional, McKeown, Craig A, additional, McLaughlin, James, additional, McMullen, W Wynn, additional, Melamed, Shlomo, additional, Meligonis, George, additional, Mendrinos, Efstratios, additional, Meyer, Dale R, additional, Meyerle, Catherine B, additional, Mieler, William F, additional, Migliori, Michael, additional, Mihm, Martin C, additional, Miller, Darlene, additional, Miller, David, additional, Miller, Joan W, additional, Miller, Neil R, additional, Mills, David M, additional, Mills, Monte D, additional, Milman, Tatyana, additional, Mogk, Lylas, additional, Mogk, Marja, additional, Monés, Jordi, additional, Montes-Micó, Robert, additional, Morse, Christie L, additional, Morton, Asa D, additional, Moskowitz, Anne, additional, Mukai, Shizuo, additional, Murphree, A Linn, additional, Murphy, Robert P, additional, Murray, Timothy G, additional, Murray, Philip I, additional, Nagao, Karina, additional, Neitz, Jay, additional, Neitz, Maureen, additional, Netland, Peter A, additional, Neufeld, Arthur H, additional, Newman, Nancy J, additional, Ng, Eugene WM, additional, Nguyen, Quan Dong, additional, Niederkorn, Jerry Y, additional, Noecker, Robert J, additional, Nussenblatt, Robert B, additional, O'Brien, Joan M, additional, O'Brien, Paul D, additional, O'Brien, Terrence P, additional, O'Day, Denis, additional, Olk, R Joseph, additional, Olsen, Karl R, additional, Onal, Sumru, additional, Ooi, Yen Hoong, additional, Opremcak, E Mitchel, additional, Ousler, George, additional, Ozment, Randall R, additional, Packer, Samuel, additional, Palmer, Millicent L, additional, Papaliodis, George N, additional, Park, DJ John, additional, Parke, David W, additional, Parsa, Cameron F, additional, Parsons, M Andrew, additional, Pasquale, Louis R, additional, Patel, Neha N, additional, Patel, Sayjal J, additional, Patrianakos, Thomas D, additional, Patrinely, James R, additional, Pavan-Langston, Deborah, additional, Peli, Eli, additional, Pepin, Susan M, additional, Perez, Victor L, additional, Pérez-Santonja, Juan J, additional, Perfect, John R, additional, Perry, Henry D, additional, Piatigorsky, Joram, additional, Pieramici, Dante, additional, Pierce, Eric A, additional, Pineda, Roberto, additional, Pless, Misha L, additional, Pomeranz, Howard D, additional, Pournaras, Constantin J, additional, Power, William, additional, Prakash, Manvi, additional, Prasad, Anita G, additional, Purvin, Valerie, additional, Quillen, David A, additional, Quinn, Graham E, additional, Rabena, Melvin D, additional, Rae, James L, additional, Raizman, Michael B, additional, Randazzo, Alessandro, additional, Rao, Narsing A, additional, Rapuano, Christopher J, additional, Reeves, Sherman W, additional, Regillo, Carl D, additional, Reichel, Elias, additional, Reinke, Martin H, additional, Rhee, Douglas, additional, Richter, Claudia U, additional, Rizzo, Joseph F, additional, Robb, Richard M, additional, Roden, Anja C, additional, Rodgers, I Rand, additional, Rodrigues, Merlyn M, additional, Ron, Yonina, additional, Rose, Geoffrey E, additional, Rosen, Emanuel S, additional, Rosenbaum, James T, additional, Rosenthal, Perry, additional, Rouse, Strutha C, additional, Rovner, Barry W, additional, Rozanowska, Malgorzata, additional, Rubin, Michael P, additional, Rubin, Peter AD, additional, Rumelt, Shimon, additional, Rustgi, Anil K, additional, Rutar, Tina, additional, Ruttum, Mark S, additional, Rutzen, Allan R, additional, Ryan, Edward T, additional, Sadun, Alfredo A, additional, Sahel, José-Alain, additional, Saligan, Leorey, additional, Salim, Sarwat, additional, Salmon, John F, additional, Salomão, Diva R, additional, Sami, David, additional, Sandberg, Michael A, additional, Sangwan, Virender S, additional, Saornil, Maria A, additional, Sassani, Joseph W, additional, Sayegh, Rony R, additional, Schachat, Andrew P, additional, Schell, Wiley A, additional, Schefler, Amy C, additional, Scheufele, Tina, additional, Schiedler, Vivian, additional, Schneider, Gretchen, additional, Schroeder, Alison, additional, Schuchard, Ronald A, additional, Schuman, Joel S, additional, Schwab, Ivan R, additional, Scott, Adrienne, additional, Scott, Ingrid U, additional, Sears, Marvin L, additional, Seddon, Johanna M, additional, Seiler, Theo, additional, Selkin, Robert P, additional, Semba, Richard D, additional, Serbanescu, Irina, additional, Sexton, Briar, additional, Shaarawy, Tarek M, additional, Shah, Peter, additional, Shapiro, Aron, additional, Sharma, Savitri, additional, Shein, Jean, additional, Shetlar, Debra J, additional, Shields, M Bruce, additional, Shields, Carol L, additional, Shields, Jerry A, additional, Shingleton, Bradford J, additional, Shore, John W, additional, Shuba, Lesya M, additional, Simon, Guy J Ben, additional, Simmons, Richard J, additional, Simpson, Michael, additional, Singh, Arun D, additional, Singh, Omah S, additional, Sisley, Karen, additional, Sit, Arthur J, additional, Smerdon, David, additional, Smiddy, William E, additional, Smith, Ronald E, additional, Smith, Terry J, additional, Snebold, Neal G, additional, Sobrin, Lucia, additional, Sorenson, John A, additional, Soukiasian, Sarkis H, additional, Spaeth, George L, additional, Spaide, Richard F, additional, Srivastava, Monika, additional, Srivastava, Sunil K, additional, Stangos, Alexandros N, additional, Starck, Tomy, additional, Stark, Walter J, additional, Stein, Joshua D, additional, Steinert, Roger F, additional, Strauss, Leon, additional, Streeten, Barbara W, additional, Streilein, J Wayne, additional, Strong, James D, additional, Sugino, Ilene K, additional, Suhler, Eric B, additional, Sullivan, Timothy J, additional, Sun, Jennifer K, additional, Sunness, Janet S, additional, Sutula, Francis C, additional, Syed, Nasreen A, additional, Ta, Christopher N, additional, Takei, Hidehiro, additional, Talamo, Jonathan H, additional, Tamesis, Richard R, additional, Tamhankar, Madhura, additional, Tarbet, Kristen J, additional, Tarver-Carr, Michelle, additional, Terry, Mark A, additional, Thomas, Joseph M, additional, Thompson, Vance, additional, Thorne, Jennifer E, additional, Thurtell, Matthew J, additional, Tingey, David P, additional, To, King W, additional, Tobaigy, Faisal M, additional, Tolentino, Michael J, additional, Tong, Melissa G, additional, Torkildsen, Gail, additional, Toth, Cynthia A, additional, Traboulsi, Elias I, additional, Trucksis, Michele, additional, Tsai, James C, additional, Tsai, Julie H, additional, Tse, David T, additional, Tseng, Scheffer CG, additional, Tu, Elmer Y, additional, Udell, Ira J, additional, Valenzuela, Alejandra A, additional, Van Gelder, Russell N, additional, Van Stavern, Gregory P, additional, Vander Veen, Deborah K, additional, Vavvas, Demetrios, additional, Verity, David H, additional, Vinciguerra, Paolo, additional, Vinger, Paul F, additional, Volpe, Nicholas J, additional, Wackernagel, Werner, additional, Wadhwa, Sonal Desai, additional, Wagoner, Michael D, additional, Waheed, Nadia K, additional, Walton, David S, additional, Wand, Martin, additional, Wang, Jie Jin, additional, Warden, Scott M, additional, Webb, Lennox, additional, Weber, David, additional, Wee, Daniel, additional, Westerfeld, Corey B, additional, Westfall, Christopher T, additional, Whitcup, Scott M, additional, White, Valerie A, additional, White, William L, additional, Wickens, Jason, additional, Wiggs, Janey L, additional, Wilensky, Jacob T, additional, Wilkinson, Charles P, additional, Williams, Patrick D, additional, Wilson, David J, additional, Wilson, M Roy, additional, Wilson, Steven E, additional, Winokur, Jules, additional, Wirostko, William J, additional, Wollstein, Gadi, additional, Wong, Albert Chak Ming, additional, Wong, Tien Y, additional, Woog, John J, additional, Wride, Michael, additional, Wu, Carolyn S, additional, WuDunn, Darrell, additional, Yang, Jean, additional, Yannuzzi, Lawrence A, additional, Yaremchuk, Michael J, additional, Yeatts, R Patrick, additional, Yee, Richard W, additional, Yeh, Steven, additional, Young, Lucy HY, additional, Yu, Jenny Y, additional, Yue, Beatrice YJT, additional, Zacks, Charles M, additional, Zagelbaum, Bruce M, additional, Zamani, Maryam, additional, Zarbin, Marco, additional, Zografos, Leonidas, additional, and Zoumalan, Christopher I, additional

Published
2008
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21. The clinical utility of a glaucoma polygenic risk score in four population-based European-ancestry cohorts.

Author

de Vries VA, Hanyuda A, Vergroesen JE, Do R, Friedman DS, Kraft P, Turman C, Luo YL, Tran JH, Liefers B, Wong SH, Lee RH, Zebardast N, Klaver CCW, Segrè AV, Pasquale LR, Wiggs JL, Kang JH, and Ramdas WD

Abstract

Objective: We used a polygenic risk score (PRS) to identify high-risk groups for primary open-angle glaucoma (POAG) within population-based cohorts., Design: Secondary analysis of four prospective population-based studies., Participants: We included four European-ancestry cohorts: the United States (US) based Nurses' Health Study (NHS), NHS2, and the Health Professionals Follow-up Study, and the Rotterdam Study (RS) in the Netherlands. The US cohorts included female nurses and male health professionals aged 55+ years. The RS included residents aged 45 years or older living in Rotterdam, the Netherlands., Methods: PRS weights were estimated by applying the Lassosum method on imputed genotype and phenotype data from the UK-Biobank. This resulted in 144,020 variants, single nucleotide polymorphism (SNPs) and indels, with non-zero betas that we used to calculate a PRS in the target populations. Using multivariable Cox proportional hazard models, we estimated the relationship between the standardized PRS and relative risk for POAG. Additionally, POAG prediction was tested by calculating these models' concordance (Harrell's C-statistic). Finally, we assessed the association between PRS tertiles and glaucoma-related traits., Main Outcome Measures: The relative risk for POAG and Harrell's C-statistic (the equivalent of an area-under-the-curve for longitudinal models)., Results: Among 1,046 cases and 38,809‬ controls, the relative risk (95% confidence interval) for POAG for participants in the highest PRS quintile was 3.99 (3.08, 5.18) in the US cohorts, and 4.89 (2.93, 8.17) in the Rotterdam Study, compared with participants with median genetic risk (3 rd quintile). In restricted cubic spline analyses, the relation between continuous PRS and POAG risk increased exponentially in the US and Rotterdam cohorts (P spline <0.05). Combining age, sex, intraocular pressure >25 mmHg, and family history resulted in a meta-analyzed concordance of 0.75 (0.73, 0.75). Adding the PRS to this model improved the concordance to 0.82 (0.80, 0.84). In a meta-analysis of all cohorts, cases in the highest tertile had a larger cup-disc ratio at diagnosis, by 0.11 (0.07, 0.15), and a 2.07-fold increased risk of requiring glaucoma surgery (1.19, 3.60)., Conclusions: Incorporating a PRS into a POAG predictive model improves identification concordance from 0.75 up to 0.82, supporting its potential for guiding more cost-effective screening strategies., (Copyright © 2024. Published by Elsevier Inc.)

Published
2024
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22. The Association of Physical Activity with Glaucoma and Related Traits in the UK Biobank.

Author

Madjedi KM, Stuart KV, Chua SYL, Ramulu PY, Warwick A, Luben RN, Sun Z, Chia MA, Aschard H, Wiggs JL, Kang JH, Pasquale LR, Foster PJ, and Khawaja AP

Subjects
Humans, Biological Specimen Banks, Cross-Sectional Studies, Intraocular Pressure, Retinal Ganglion Cells, Tomography, Optical Coherence, United Kingdom epidemiology, Mendelian Randomization Analysis, Glaucoma genetics, Macula Lutea
Abstract

Purpose: To examine the association of physical activity (PA) with glaucoma and related traits, to assess whether genetic predisposition to glaucoma modified these associations, and to probe causal relationships using Mendelian randomization (MR)., Design: Cross-sectional observational and gene-environment interaction analyses in the UK Biobank. Two-sample MR experiments using summary statistics from large genetic consortia., Participants: UK Biobank participants with data on self-reported or accelerometer-derived PA and intraocular pressure (IOP; n = 94 206 and n = 27 777, respectively), macular inner retinal OCT measurements (n = 36 274 and n = 9991, respectively), and glaucoma status (n = 86 803 and n = 23 556, respectively)., Methods: We evaluated multivariable-adjusted associations of self-reported (International Physical Activity Questionnaire) and accelerometer-derived PA with IOP and macular inner retinal OCT parameters using linear regression and with glaucoma status using logistic regression. For all outcomes, we examined gene-PA interactions using a polygenic risk score (PRS) that combined the effects of 2673 genetic variants associated with glaucoma., Main Outcome Measures: Intraocular pressure, macular retinal nerve fiber layer (mRNFL) thickness, macular ganglion cell-inner plexiform layer (mGCIPL) thickness, and glaucoma status., Results: In multivariable-adjusted regression models, we found no association of PA level or time spent in PA with glaucoma status. Higher overall levels and greater time spent in higher levels of both self-reported and accelerometer-derived PA were associated positively with thicker mGCIPL (P < 0.001 for trend for each). Compared with the lowest quartile of PA, participants in the highest quartiles of accelerometer-derived moderate- and vigorous-intensity PA showed a thicker mGCIPL by +0.57 μm (P < 0.001) and +0.42 μm (P = 0.005). No association was found with mRNFL thickness. High overall level of self-reported PA was associated with a modestly higher IOP of +0.08 mmHg (P = 0.01), but this was not replicated in the accelerometry data. No associations were modified by a glaucoma PRS, and MR analyses did not support a causal relationship between PA and any glaucoma-related outcome., Conclusions: Higher overall PA level and greater time spent in moderate and vigorous PA were not associated with glaucoma status but were associated with thicker mGCIPL. Associations with IOP were modest and inconsistent. Despite the well-documented acute reduction in IOP after PA, we found no evidence that high levels of habitual PA are associated with glaucoma status or IOP in the general population., Financial Disclosure(s): Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article., (Copyright © 2023 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved.)

Published
2023
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23. Mitochondrial TXNRD2 and ME3 Genetic Risk Scores Are Associated with Specific Primary Open-Angle Glaucoma Phenotypes.

Author

Aboobakar IF, Kinzy TG, Zhao Y, Fan B, Pasquale LR, Qassim A, Kolovos A, Schmidt JM, Craig JE, Cooke Bailey JN, and Wiggs JL

Subjects
Humans, Genetic Predisposition to Disease, Cross-Sectional Studies, Phenotype, Intraocular Pressure, Risk Factors, Thioredoxin Reductase 2 genetics, Genome-Wide Association Study, Glaucoma, Open-Angle diagnosis, Glaucoma, Open-Angle genetics
Abstract

Purpose: Genetic variants in regions that include the mitochondrial genes thioredoxin reductase 2 (TXNRD2) and malic enzyme 3 (ME3) are associated with primary open-angle glaucoma (POAG) in genome-wide association studies (GWASs). To assess their clinical impact, we investigated whether TXNRD2 and ME3 genetic risk scores (GRSs) are associated with specific glaucoma phenotypes., Design: Cross-sectional study., Participants: A total of 2617 patients with POAG and 2634 control participants from the National Eye Institute Glaucoma Human Genetics Collaboration Hereditable Overall Operational Database (NEIGHBORHOOD) consortium., Methods: All POAG-associated single nucleotide polymorphisms (SNPs) in the TXNRD2 and ME3 loci were identified using GWAS data (P < 0.05). Of these, 20 TXNRD2 and 24 ME3 SNPs were selected after adjusting for linkage disequilibrium. The correlation between SNP effect size and gene expression levels was investigated using the Gene-Tissue Expression database. Genetic risk scores were constructed for each individual using the unweighted sum of TXNRD2, ME3, and TXNRD2 + ME3 combined risk alleles. Age- and sex-adjusted odds ratios (ORs) for POAG diagnosis were calculated per decile for each GRS. Additionally, the clinical features of patients with POAG in the top 1%, 5%, and 10% of each GRS were compared with those in the bottom 1%, 5%, and 10%, respectively., Main Outcome Measures: Primary open-angle glaucoma OR per GRS decile, maximum treated intraocular pressure (IOP), and prevalence of paracentral visual field loss among patients with POAG with high versus low GRSs., Results: A larger SNP effect size strongly correlated with higher TXNRD2 and lower ME3 expression levels (r = 0.95 and r = -0.97, respectively; P < 0.05 for both). Individuals in decile 10 of the TXNRD2 + ME3 GRS had the highest odds of POAG diagnosis (OR, 1.79 compared with decile 1; 95% confidence interval, 1.39-2.30; P < 0.001). Patients with POAG in the top 1% of the TXNRD2 GRS showed higher mean maximum treated IOP compared with the bottom 1% (19.9 mmHg vs. 15.6 mmHg; adjusted P = 0.03). Patients with POAG in the top 1% of the ME3 and TXNRD2 + ME3 GRS showed a higher prevalence of paracentral field loss than the bottom 1% (72.7% vs. 14.3% for ME3 GRS and 88.9% vs. 33.3% for TXNRD2+ME3 GRS; adjusted P = 0.03 for both)., Conclusions: Patients with POAG with higher TXNRD2 and ME3 GRSs showed higher treated IOP and a greater prevalence of paracentral field loss. Functional studies exploring how these variants impact mitochondrial function in patients with glaucoma are warranted., Financial Disclosure(s): Proprietary or commercial disclosure may be found after the references., (Copyright © 2023 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved.)

Published
2023
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24. Long-term Alcohol Consumption and Risk of Exfoliation Glaucoma or Glaucoma Suspect Status among United States Health Professionals.

Author

Hanyuda A, Rosner BA, Wiggs JL, Negishi K, Pasquale LR, and Kang JH

Subjects
Humans, United States epidemiology, Follow-Up Studies, Prospective Studies, Risk Factors, Alcohol Drinking adverse effects, Alcohol Drinking epidemiology, Exfoliation Syndrome epidemiology, Exfoliation Syndrome etiology, Glaucoma diagnosis, Glaucoma epidemiology, Glaucoma etiology, Ocular Hypertension
Abstract

Purpose: To assess the association between intakes of total alcohol and individual alcoholic beverages and the incidence of exfoliation glaucoma/glaucoma suspect (XFG/XFGS) status., Design: Prospective cohort study., Participants: A total of 195 408 participants in the Nurses' Health Study (1980-2018), the Health Professionals Follow-up Study (1986-2018), and the Nurses' Health Study II (1991-2019) were followed biennially. Eligible participants at each 2-year risk period were ≧ 40 years and free of XFG/XFGS status with available data on diet and ophthalmic examination findings., Methods: Cumulatively averaged total (primary exposure) and individual alcoholic beverage (beer, wine, and liquor) intakes from validated dietary information every 2-4 years., Main Outcome Measures: Confirmed incident XFG/XFGS status using medical records. We used per-eye Cox proportional hazards models, accounting for intereye correlations, to estimate multivariate-adjusted relative risks (MVRRs) and 95% confidence intervals (CIs)., Results: During 6 877 823 eye-years of follow-up, 705 eyes with XFG/XFGS status were documented. Greater total alcohol consumption was associated significantly with higher XFG/XFGS status risk: the MVRR for XFG/XFGS status for cumulatively averaged alcohol consumption of ≧15 g/day or more versus nondrinking was 1.55 (95% CI, 1.17-2.07; P = 0.02 for trend). Long- and short-term alcohol intake was associated significantly with XFG/XFGS status risk, with the strongest associations with cumulatively averaged alcohol intake as of 4 years before diagnosis (MVRR ≥ 15 g/day vs. nondrinking, 1.65; 95% CI, 1.25-2.18; P = 0.002 for trend). Compared with nondrinkers, consuming ≧ 3.6 drinks of beer, wine, or liquor per week was associated with the following MVRRs for XFG/XFGS status: 1.26 (95% CI, 0.89-1.77; P = 0.40 for trend), 1.30 (95% CI, 1.00-1.68; P = 0.15 for trend), and 1.46 (95% CI, 1.15-1.85; P = 0.01 for trend), respectively. We did not observe interactions by age, latitude, residential tier, or intakes of folate or vitamin A (P > 0.40 for interaction); however, the association between alcohol and XFG/XFGS status was suggestively stronger for those without a family history of glaucoma (P = 0.10 for interaction)., Conclusions: Long-term alcohol consumption was associated with a higher risk of XFG/XFGS status. Our findings provide further clues regarding the XFG/XFGS etiology., (Copyright © 2022 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved.)

Published
2023
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25. The Association between Serum Lipids and Intraocular Pressure in 2 Large United Kingdom Cohorts.

Author

Madjedi KM, Stuart KV, Chua SYL, Luben RN, Warwick A, Pasquale LR, Kang JH, Wiggs JL, Lentjes MAH, Aschard H, Sattar N, Foster PJ, and Khawaja AP

Subjects
Aged, Cholesterol, HDL, Cholesterol, LDL, Cross-Sectional Studies, Humans, Middle Aged, Prospective Studies, Risk Factors, Triglycerides, United Kingdom epidemiology, Intraocular Pressure
Abstract

Purpose: Serum lipids are modifiable, routinely collected blood test features associated with cardiovascular health. We examined the association of commonly collected serum lipid measures (total cholesterol [TC], high-density lipoprotein cholesterol [HDL-C], low-density lipoprotein cholesterol [LDL-C], and triglycerides) with intraocular pressure (IOP)., Design: Cross-sectional study in the UK Biobank and European Prospective Investigation into Cancer and Nutrition (EPIC)-Norfolk cohorts., Participants: We included 94 323 participants from the UK Biobank (mean age, 57 years) and 6230 participants from the EPIC-Norfolk (mean age, 68 years) cohorts with data on TC, HDL-C, LDL-C, and triglycerides collected between 2006 and 2009., Methods: Multivariate linear regression adjusting for demographic, lifestyle, anthropometric, medical, and ophthalmic covariables was used to examine the associations of serum lipids with corneal-compensated IOP (IOPcc)., Main Outcome Measures: Corneal-compensated IOP., Results: Higher levels of TC, HDL-C, and LDL-C were associated independently with higher IOPcc in both cohorts after adjustment for key demographic, medical, and lifestyle factors. For each 1-standard deviation increase in TC, HDL-C, and LDL-C, IOPcc was higher by 0.09 mmHg (95% confidence interval [CI], 0.06-0.11 mmHg; P < 0.001), 0.11 mmHg (95% CI, 0.08-0.13 mmHg; P < 0.001), and 0.07 mmHg (95% CI, 0.05-0.09 mmHg; P < 0.001), respectively, in the UK Biobank cohort. In the EPIC-Norfolk cohort, each 1-standard deviation increase in TC, HDL-C, and LDL-C was associated with a higher IOPcc by 0.19 mmHg (95% CI, 0.07-0.31 mmHg; P = 0.001), 0.14 mmHg (95% CI, 0.03-0.25 mmHg; P = 0.016), and 0.17 mmHg (95% CI, 0.06-0.29 mmHg; P = 0.003). An inverse association between triglyceride levels and IOP in the UK Biobank (-0.05 mmHg; 95% CI, -0.08 to -0.03; P < 0.001) was not replicated in the EPIC-Norfolk cohort (P = 0.30)., Conclusions: Our findings suggest that serum TC, HDL-C, and LDL-C are associated positively with IOP in 2 United Kingdom cohorts and that triglyceride levels may be associated negatively. Future research is required to assess whether these associations are causal in nature., (Copyright © 2022 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved.)

Published
2022
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26. Alcohol, Intraocular Pressure, and Open-Angle Glaucoma: A Systematic Review and Meta-analysis.

Author

Stuart KV, Madjedi K, Luben RN, Chua SYL, Warwick AN, Chia M, Pasquale LR, Wiggs JL, Kang JH, Hysi PG, Tran JH, Foster PJ, and Khawaja AP

Subjects
Cross-Sectional Studies, Ethanol therapeutic use, Humans, Intraocular Pressure, Tonometry, Ocular, Glaucoma, Open-Angle drug therapy, Glaucoma, Open-Angle epidemiology, Glaucoma, Open-Angle etiology, Ocular Hypertension etiology
Abstract

Topic: This systematic review and meta-analysis summarizes the existing evidence for the association of alcohol use with intraocular pressure (IOP) and open-angle glaucoma (OAG)., Clinical Relevance: Understanding and quantifying these associations may aid clinical guidelines or treatment strategies and shed light on disease pathogenesis. The role of alcohol, a modifiable factor, in determining IOP and OAG risk also may be of interest from an individual or public health perspective., Methods: The study protocol was preregistered in the Open Science Framework Registries (https://osf.io/z7yeg). Eligible articles (as of May 14, 2021) from 3 databases (PubMed, Embase, Scopus) were independently screened and quality assessed by 2 reviewers. All case-control, cross-sectional, and cohort studies reporting a quantitative effect estimate and 95% confidence interval (CI) for the association between alcohol use and either IOP or OAG were included. The evidence for the associations with both IOP and OAG was qualitatively summarized. Effect estimates for the association with OAG were pooled using random effects meta-analysis. Studies not meeting formal inclusion criteria for systematic review, but with pertinent results, were also appraised and discussed. Certainty of evidence was assessed using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) framework., Results: Thirty-four studies were included in the systematic review. Evidence from 10 studies reporting an association with IOP suggests that habitual alcohol use is associated with higher IOP and prevalence of ocular hypertension (IOP > 21 mmHg), although absolute effect sizes were small. Eleven of 26 studies, comprising 173 058 participants, that tested for an association with OAG met inclusion criteria for meta-analysis. Pooled effect estimates indicated a positive association between any use of alcohol and OAG (1.18; 95% confidence interval [CI], 1.02-1.36; P = 0.03; I 2  = 40.5%), with similar estimates for both prevalent and incident OAG. The overall GRADE certainty of evidence was very low., Conclusions: Although this meta-analysis suggests a harmful association between alcohol use and OAG, our results should be interpreted cautiously given the weakness and heterogeneity of the underlying evidence base, the small absolute effect size, and the borderline statistical significance. Nonetheless, these findings may be clinically relevant, and future research should focus on improving the quality of evidence., (Copyright © 2022 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved.)

Published
2022
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27. Photoreceptor Layer Thinning Is an Early Biomarker for Age-Related Macular Degeneration: Epidemiologic and Genetic Evidence from UK Biobank OCT Data.

Author

Zekavat SM, Sekimitsu S, Ye Y, Raghu V, Zhao H, Elze T, Segrè AV, Wiggs JL, Natarajan P, Del Priore L, Zebardast N, and Wang JC

Subjects
Adult, Aged, Biological Specimen Banks, Biomarkers, Cohort Studies, Female, High-Temperature Requirement A Serine Peptidase 1 genetics, Humans, Male, Middle Aged, Retinal Pigment Epithelium, United Kingdom epidemiology, Macular Degeneration diagnosis, Macular Degeneration epidemiology, Macular Degeneration genetics, Tomography, Optical Coherence methods
Abstract

Purpose: Despite widespread use of OCT, an early-stage imaging biomarker for age-related macular degeneration (AMD) has not been identified. Pathophysiologically, the timing of drusen accumulation in relationship to photoreceptor degeneration in AMD remains unclear, as are the inherited genetic variants contributing to these processes. Herein, we jointly analyzed OCT, electronic health record data, and genomic data to characterize the time sequence of changes in retinal layer thicknesses in AMD, as well as epidemiologic and genetic associations between retinal layer thicknesses and AMD., Design: Cohort study., Participants: Forty-four thousand eight hundred twenty-three individuals from the UK Biobank (enrollment age range, 40-70 years; 54% women; median follow-up, 10 years)., Methods: The Topcon Advanced Boundary Segmentation algorithm was used for retinal layer segmentation. We associated 9 retinal layer thicknesses with prevalent AMD (present at enrollment) in a logistic regression model and with incident AMD (diagnosed after enrollment) in a Cox proportional hazards model. Next, we associated AMD-associated genetic alleles, individually and as a polygenic risk score (PRS), with retinal layer thicknesses. All analyses were adjusted for age, age-squared (age 2 ), sex, smoking status, and principal components of ancestry., Main Outcome Measures: Prevalent and incident AMD., Results: Photoreceptor segment (PS) thinning was observed throughout the lifespan of individuals analyzed, whereas retinal pigment epithelium (RPE) and Bruch's membrane (BM) complex thickening started after 57 years of age. Each standard deviation (SD) of PS thinning and RPE-BM complex thickening was associated with incident AMD (PS: hazard ratio [HR], 1.35; 95% confidence interval [CI], 1.23-1.47; P = 3.7 × 10 - 11 ; RPE-BM complex: HR, 1.14; 95% CI, 1.06-1.22; P = 0.00024). The AMD PRS was associated with PS thinning (β, -0.21 SD per twofold genetically increased risk of AMD; 95% CI, -0.23 to -0.19; P = 2.8 × 10 -74 ), and its association with RPE-BM complex was U-shaped (thinning with AMD PRS less than the 92nd percentile and thickening with AMD PRS more than the 92nd percentile). The loci with strongest support for genetic correlation were AMD risk-raising variants Complement Factor H (CFH):rs570618-T, CFH:rs10922109-C, and Age-Related Maculopathy Susceptibility 2 (ARMS2)/High-Temperature Requirement Serine Protease 1 (HTRA1):rs3750846-C on PS thinning and SYN3/Tissue Inhibitor of Metalloprotease 3 (TIMP3):rs5754227-T on RPE-BM complex thickening., Conclusions: Epidemiologically, PS thinning precedes RPE-BM complex thickening by decades and is the retinal layer most strongly predictive of future AMD risk. Genetically, AMD risk variants are associated with decreased PS thickness. Overall, these findings support PS thinning as an early-stage biomarker for future AMD development., (Copyright © 2022 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved.)

Published
2022
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28. Genome-Wide Association Study Identifies Two Common Loci Associated with Pigment Dispersion Syndrome/Pigmentary Glaucoma and Implicates Myopia in its Development.

Author

Simcoe MJ, Shah A, Fan B, Choquet H, Weisschuh N, Waseem NH, Jiang C, Melles RB, Ritch R, Mahroo OA, Wissinger B, Jorgenson E, Wiggs JL, Garway-Heath DF, Hysi PG, and Hammond CJ

Subjects
Genome-Wide Association Study, Humans, Intraocular Pressure, Polymorphism, Single Nucleotide, Glaucoma, Open-Angle genetics, Myopia genetics
Abstract

Purpose: To identify genetic variants associated with pigment dispersion syndrome (PDS) and pigmentary glaucoma (PG) in unrelated patients and to further understand the genetic and potentially causal relationships between PDS and associated risk factors., Design: A 2-stage genome-wide association meta-analysis with replication and subsequent in silico analyses including Mendelian randomization., Participants: A total of 574 cases with PG or PDS and 52 627 controls of European descent., Methods: Genome-wide association analyses were performed in 4 cohorts and meta-analyzed in 3 stages: (1) a discovery meta-analysis was performed in 3 cohorts, (2) replication was performed in the fourth cohort, and (3) all 4 cohorts were meta-analyzed to increase statistical power. Two-sample Mendelian randomization was used to determine whether refractive error and intraocular pressure exert causal effects over PDS., Main Outcome Measures: The association of genetic variants with PDS and whether myopia exerts causal effects over PDS., Results: Significant association was present at 2 novel loci for PDS/PG. These loci and follow-up analyses implicate the genes gamma secretase activator protein (GSAP) (lead single nucleotide polymorphism [SNP]: rs9641220, P = 6.0×10 -10 ) and glutamate metabotropic receptor 5 (GRM5)/TYR (lead SNP: rs661177, P = 3.9×10 -9 ) as important factors in disease risk. Mendelian randomization showed significant evidence that negative refractive error (myopia) exerts a direct causal effect over PDS (P = 8.86×10 -7 )., Conclusions: Common SNPs relating to the GSAP and GRM5/TYR genes are associated risk factors for the development of PDS and PG. Although myopia is a known risk factor, this study uses genetic data to demonstrate that myopia is, in part, a cause of PDS and PG., (Copyright © 2022 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved.)

Published
2022
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29. Characteristics of p.Gln368Ter Myocilin Variant and Influence of Polygenic Risk on Glaucoma Penetrance in the UK Biobank.

Author

Zebardast N, Sekimitsu S, Wang J, Elze T, Gharahkhani P, Cole BS, Lin MM, Segrè AV, and Wiggs JL

Subjects
Adult, Aged, Biological Specimen Banks, Cross-Sectional Studies, Female, Genome-Wide Association Study, Glaucoma, Open-Angle diagnosis, Glaucoma, Open-Angle physiopathology, Humans, Intraocular Pressure, Male, Middle Aged, Nerve Fibers pathology, Penetrance, Retinal Ganglion Cells pathology, Tomography, Optical Coherence, United Kingdom, Cytoskeletal Proteins genetics, Eye Proteins genetics, Glaucoma, Open-Angle genetics, Glycoproteins genetics, Multifactorial Inheritance genetics, Mutation
Abstract

Purpose: MYOC (myocilin) mutations account for 3% to 5% of primary open-angle glaucoma (POAG) cases. We aimed to understand the true population-wide penetrance and characteristics of glaucoma among individuals with the most common MYOC variant (p.Gln368Ter) and the impact of a POAG polygenic risk score (PRS) in this population., Design: Cross-sectional population-based study., Participants: Individuals with the p.Gln368Ter variant among 77 959 UK Biobank participants with fundus photographs (FPs)., Methods: A genome-wide POAG PRS was computed, and 2 masked graders reviewed FPs for disc-defined glaucoma (DDG)., Main Outcome Measures: Penetrance of glaucoma., Results: Two hundred individuals carried the p.Gln368Ter heterozygous genotype, and 177 had gradable FPs. One hundred thirty-two showed no evidence of glaucoma, 45 (25.4%) had probable/definite glaucoma in at least 1 eye, and 19 (10.7%) had bilateral glaucoma. No differences were found in age, race/ethnicity, or gender among groups (P > 0.05). Of those with DDG, 31% self-reported or had International Classification of Diseases codes for glaucoma, whereas 69% were undiagnosed. Those with DDG had higher medication-adjusted cornea-corrected intraocular pressure (IOPcc) (P < 0.001) vs. those without glaucoma. This difference in IOPcc was larger in those with DDG with a prior glaucoma diagnosis versus those not diagnosed (P < 0.001). Most p.Gln368Ter carriers showed IOP in the normal range (≤21 mmHg), although this proportion was lower in those with DDG (P < 0.02) and those with prior glaucoma diagnosis (P < 0.03). Prevalence of DDG increased with each decile of POAG PRS. Individuals with DDG demonstrated significantly higher PRS compared with those without glaucoma (0.37 ± 0.97 vs. 0.01 ± 0.90; P = 0.03). Of those with DDG, individuals with a prior diagnosis of glaucoma had higher PRS compared with undiagnosed individuals (1.31 ± 0.64 vs. 0.00 ± 0.81; P < 0.001) and 27.5 times (95% confidence interval, 2.5-306.6) adjusted odds of being in the top decile of PRS for POAG., Conclusions: One in 4 individuals with the MYOC p.Gln368Ter mutation demonstrated evidence of glaucoma, a substantially higher penetrance than previously estimated, with 69% of cases undetected. A large portion of p.Gln368Ter carriers, including those with DDG, have IOP in the normal range, despite similar age. Polygenic risk score increases disease penetrance and severity, supporting the usefulness of PRS in risk stratification among MYOC p.Gln368Ter carriers., (Copyright © 2021 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved.)

Published
2021
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30. Intraocular Pressure, Glaucoma, and Dietary Caffeine Consumption: A Gene-Diet Interaction Study from the UK Biobank.

Author

Kim J, Aschard H, Kang JH, Lentjes MAH, Do R, Wiggs JL, Khawaja AP, and Pasquale LR

Subjects
Adult, Aged, Cross-Sectional Studies, Female, Follow-Up Studies, Glaucoma etiology, Glaucoma physiopathology, Humans, Male, Mendelian Randomization Analysis methods, Middle Aged, Prospective Studies, Risk Factors, United Kingdom, Biological Specimen Banks statistics & numerical data, Caffeine administration & dosage, Genetic Predisposition to Disease, Glaucoma genetics, Intraocular Pressure physiology
Abstract

Purpose: We examined the association of habitual caffeine intake with intraocular pressure (IOP) and glaucoma and whether genetic predisposition to higher IOP modified these associations. We also assessed whether genetic predisposition to higher coffee consumption was related to IOP., Design: Cross-sectional study in the UK Biobank., Participants: We included 121 374 participants (baseline ages, 39-73 years) with data on coffee and tea intake (collected 2006-2010) and corneal-compensated IOP measurements in 2009. In a subset of 77 906 participants with up to 5 web-based 24-hour-recall food frequency questionnaires (2009-2012), we evaluated total caffeine intake. We also assessed the same relationships with glaucoma (9286 cases and 189 763 controls)., Methods: We evaluated multivariable-adjusted associations with IOP using linear regression and with glaucoma using logistic regression. For both outcomes, we examined gene-diet interactions using a polygenic risk score (PRS) that combined the effects of 111 genetic variants associated with IOP. We also performed Mendelian randomization using 8 genetic variants associated with coffee intake to assess potential causal effects of coffee consumption on IOP., Main Outcome Measures: Intraocular pressure and glaucoma., Results: Mendelian randomization analysis did not support a causal effect of coffee drinking on IOP (P > 0.1). Greater caffeine intake was associated weakly with lower IOP: the highest (≥232 mg/day) versus lowest (<87 mg/day) caffeine consumption was associated with a 0.10-mmHg lower IOP (P trend  = 0.01). However, the IOP PRS modified this association: among those in the highest IOP PRS quartile, consuming > 480 mg/day versus < 80 mg/day was associated with a 0.35-mmHg higher IOP (P interaction  = 0.01). The relationship between caffeine intake and glaucoma was null (P ≥ 0.1). However, the IOP PRS also modified this relationship: compared with those in the lowest IOP PRS quartile consuming no caffeine, those in the highest IOP PRS quartile consuming ≥ 321 mg/day showed a 3.90-fold higher glaucoma prevalence (P interaction  = 0.0003)., Conclusions: Habitual caffeine consumption was associated weakly with lower IOP, and the association between caffeine consumption and glaucoma was null. However, among participants with the strongest genetic predisposition to elevated IOP, greater caffeine consumption was associated with higher IOP and higher glaucoma prevalence., (Copyright © 2020 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved.)

Published
2021
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32. Diet quality and genetic association with body mass index: results from 3 observational studies.

Author

Ding M, Ellervik C, Huang T, Jensen MK, Curhan GC, Pasquale LR, Kang JH, Wiggs JL, Hunter DJ, Willett WC, Rimm EB, Kraft P, Chasman DI, Qi L, Hu FB, and Qi Q

Subjects
Aged, Cohort Studies, Diet, Diet, Mediterranean, Energy Intake, Exercise, Female, Genotype, Humans, Male, Middle Aged, Polymorphism, Single Nucleotide genetics, Prospective Studies, Risk Factors, Body Mass Index, Diet, Healthy, Genetic Predisposition to Disease genetics
Abstract

Background: It is unknown whether dietary quality modifies genetic association with body mass index (BMI)., Objective: This study examined whether dietary quality modifies genetic association with BMI., Design: We calculated 3 diet quality scores including the Alternative Healthy Eating Index 2010 (AHEI-2010), the Alternative Mediterranean Diet score (AMED), and the Dietary Approach to Stop Hypertension (DASH) diet score. We examined the interactions of a genetic risk score (GRS) based on 97 BMI-associated variants with the 3 diet quality scores on BMI in 30,904 participants from 3 large cohorts., Results: We found significant interactions between total GRS and all 3 diet scores on BMI assessed after 2-3 y, with an attenuated genetic effect observed in individuals with healthier diets (AHEI: P-interaction = 0.003; AMED: P = 0.001; DASH: P = 0.004). For example, the difference in BMI (kg/m2) per 10-unit increment of the GRS was smaller among participants in the highest tertile of AHEI score compared with those in the lowest tertile (0.84; 95% CI: 0.72, 0.96 compared with 1.14; 95% CI: 0.99, 1.29). Results were consistent across the 3 cohorts with no significant heterogeneity. The interactions with diet scores on BMI appeared more significant for central nervous system GRSs (P < 0.01 for 3 diet scores) than for non-central nervous system GRSs (P > 0.05 for 3 diet scores)., Conclusions: A higher diet quality attenuated genetic predisposition to obesity. These findings underscore the importance of maintaining a healthful diet for the prevention of obesity, particularly for those individuals with a strong genetic predisposition to obesity. This trial was registered with the Clinical Trial Registry as NCT03577639.

Published
2018
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33. Reply.

Author

Pasquale LR, Hyman L, Wiggs JL, Rosner BA, Joshipura K, McEvoy M, McPherson ZE, Danias J, and Kang JH

Published
2017
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34. Demographic, Systemic, and Ocular Factors Associated with Nonarteritic Anterior Ischemic Optic Neuropathy.

Author

Cestari DM, Gaier ED, Bouzika P, Blachley TS, De Lott LB, Rizzo JF, Wiggs JL, Kang JH, Pasquale LR, and Stein JD

Subjects
Adult, Aged, Aged, 80 and over, Arteritis diagnosis, Arteritis physiopathology, Cohort Studies, Female, Follow-Up Studies, Humans, Male, Managed Care Programs, Middle Aged, Optic Neuropathy, Ischemic diagnosis, Optic Neuropathy, Ischemic physiopathology, Proportional Hazards Models, Retrospective Studies, Risk Factors, United States epidemiology, Visual Acuity physiology, Arteritis epidemiology, Optic Neuropathy, Ischemic epidemiology
Abstract

Objective: Nonarteritic anterior ischemic optic neuropathy (NAION) is a devastating ocular condition causing permanent vision loss. Little is known about risk factors for developing this disease. We assessed demographic, systemic, and ocular factors associated with NAION., Design: Retrospective longitudinal cohort study., Participants: Beneficiaries between 40 and 75 years old without NAION at baseline enrolled in a large U.S. managed care network., Methods: Enrollees were monitored continuously for ≥2 years between 2001 and 2014 to identify those newly diagnosed with NAION (International Classification of Diseases, 9th Revision, Clinical Modification [ICD-9-CM] code 377.41). All persons were under ophthalmic surveillance and all cases had ≥1 confirmatory ICD-9-CM code for NAION during follow-up., Main Outcome Measures: Multivariable Cox regression modeling was used to generate hazard ratios (HRs) with 95% confidence intervals (CIs) to describe the statistical relationship between selected demographic characteristics, systemic and ocular conditions, and the hazard of developing NAION., Results: Of 1 381 477 eligible enrollees, 977 (0.1%) developed NAION during a mean ± standard deviation (SD) follow-up of 7.8±3.1 years. The mean ± SD age for NAION cases at the index date was 64.0±9.2 years vs. 58.4±9.4 years for the remainder of the beneficiaries. After adjustment for confounding factors, each additional year older was associated with a 2% increased hazard of NAION (HR = 1.02; 95% CI: 1.01-1.03). Female subjects had a 36% decreased hazard of developing NAION (HR = 0.64; 95% CI: 0.55-0.74) compared with male subjects. Compared with whites, Latinos had a 46% decreased hazard of developing NAION (HR = 0.54; 95% CI: 0.36-0.82), whereas African ancestry was not significantly associated with NAION (HR = 0.91; 95% CI: 0.72-1.15). Systemic diseases associated with NAION included hypertension (HR = 1.62; 95% CI: 1.26-2.07) and hypercoagulable states (HR = 2.46; 95% CI: 1.51-4.00). Although diabetes mellitus (DM) was not significantly associated with NAION compared with those without DM (P = 0.45), patients with end-organ involvement from DM had a 27% increased hazard of NAION relative to those with uncomplicated DM (HR = 1.27; 95% CI: 1.01-1.59). Ocular diseases associated with NAION were age-related macular degeneration (HR = 1.29; 95% CI: 1.08-1.54) and retinal vein occlusion (HR = 3.94; 95% CI: 3.11-4.99)., Conclusions: Our study identified several modifiable risk factors that may be associated with NAION. Should future studies confirm these findings, they may offer opportunities to prevent or treat this debilitating condition., (Copyright © 2016 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved.)

Published
2016
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35. Prospective Study of Oral Health and Risk of Primary Open-Angle Glaucoma in Men: Data from the Health Professionals Follow-up Study.

Author

Pasquale LR, Hyman L, Wiggs JL, Rosner BA, Joshipura K, McEvoy M, McPherson ZE, Danias J, and Kang JH

Subjects
Follow-Up Studies, Glaucoma, Open-Angle epidemiology, Glaucoma, Open-Angle physiopathology, Humans, Male, Middle Aged, Prevalence, Prognosis, Prospective Studies, Risk Factors, Time Factors, Tonometry, Ocular, United States epidemiology, Glaucoma, Open-Angle diagnosis, Health Personnel, Intraocular Pressure physiology, Oral Health, Risk Assessment methods, Visual Fields physiology
Abstract

Purpose: Tooth loss or periodontal disease is associated with systemic endothelial dysfunction, which has been implicated in primary open-angle glaucoma (POAG). The relationship between oral health and POAG has received limited attention. Thus, we evaluated the association between oral health history and risk of POAG and POAG subtypes., Design: Prospective cohort study., Participants: Health Professionals Follow-up Study participants (40 536 men) followed biennially from 1986 to 2012. At each 2-year risk period, eligible participants were aged 40+ years, were free of POAG, and reported eye examinations., Methods: By using validated questions, we updated participants' status on number of natural teeth, teeth lost, periodontal disease with bone loss, and root canal treatments., Main Outcome Measures: During follow-up, 485 incident cases of POAG were confirmed with medical records and classified into subtypes defined by intraocular pressure (IOP; ≥ or <22 mmHg) or visual field (VF) loss pattern at diagnosis (peripheral loss only or early paracentral loss). Multivariable relative risks (MVRRs) and 95% confidence intervals (CIs) were estimated., Results: Number of natural teeth, periodontal disease, and root canal treatment were not associated with POAG. However, compared with no report of tooth loss, a report of losing teeth within the past 2 years was associated with a 1.45-fold increased risk of POAG (95% CI, 1.06-1.97); in particular, a report within the past 2 years of both losing teeth and having a prevalent diagnosis of periodontal disease was associated with a 1.85-fold increased risk of POAG (95% CI, 1.07-3.18). The associations with recent tooth loss were not significantly different for the POAG subtypes (P for heterogeneity ≥0.36), although associations were strongest in relation to the POAG subtypes with IOP <22 mmHg (MVRR, 1.93; 95% CI, 1.09-3.43) and early paracentral VF loss (MVRR, 2.27; 95% CI, 1.32-3.88)., Conclusions: Although the number of natural teeth was not associated with risk of POAG, recent tooth loss was associated with an increased risk of POAG. Because these findings may be due to chance, they need confirmation in larger studies., (Copyright © 2016 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved.)

Published
2016
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36. Panel-based genetic diagnostic testing for inherited eye diseases is highly accurate and reproducible, and more sensitive for variant detection, than exome sequencing.

Author

Consugar MB, Navarro-Gomez D, Place EM, Bujakowska KM, Sousa ME, Fonseca-Kelly ZD, Taub DG, Janessian M, Wang DY, Au ED, Sims KB, Sweetser DA, Fulton AB, Liu Q, Wiggs JL, Gai X, and Pierce EA

Subjects
Exome genetics, Eye Diseases pathology, Genotype, Humans, Polymorphism, Single Nucleotide, Prospective Studies, Reproducibility of Results, Sensitivity and Specificity, Eye Diseases diagnosis, Eye Diseases genetics, Genetic Testing, High-Throughput Nucleotide Sequencing
Abstract

Purpose: Next-generation sequencing-based methods are being adopted broadly for genetic diagnostic testing, but the performance characteristics of these techniques with regard to test accuracy and reproducibility have not been fully defined., Methods: We developed a targeted enrichment and next-generation sequencing approach for genetic diagnostic testing of patients with inherited eye disorders, including inherited retinal degenerations, optic atrophy, and glaucoma. In preparation for providing this genetic eye disease (GEDi) test on a CLIA-certified basis, we performed experiments to measure the sensitivity, specificity, and reproducibility, as well as the clinical sensitivity, of the test., Results: The GEDi test is highly reproducible and accurate, with sensitivity and specificity of 97.9 and 100%, respectively, for single-nucleotide variant detection. The sensitivity for variant detection was notably better than the 88.3% achieved by whole-exome sequencing using the same metrics, because of better coverage of targeted genes in the GEDi test as compared with a commercially available exome capture set. Prospective testing of 192 patients with inherited retinal degenerations indicated that the clinical sensitivity of the GEDi test is high, with a diagnostic rate of 51%., Conclusion: Based on quantified performance metrics, the data suggest that selective targeted enrichment is preferable to whole-exome sequencing for genetic diagnostic testing.

Published
2015
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37. Association of CAV1/CAV2 genomic variants with primary open-angle glaucoma overall and by gender and pattern of visual field loss.

Author

Loomis SJ, Kang JH, Weinreb RN, Yaspan BL, Cooke Bailey JN, Gaasterland D, Gaasterland T, Lee RK, Lichter PR, Budenz DL, Liu Y, Realini T, Friedman DS, McCarty CA, Moroi SE, Olson L, Schuman JS, Singh K, Vollrath D, Wollstein G, Zack DJ, Brilliant M, Sit AJ, Christen WG, Fingert J, Kraft P, Zhang K, Allingham RR, Pericak-Vance MA, Richards JE, Hauser MA, Haines JL, Pasquale LR, and Wiggs JL

Subjects
Aged, Case-Control Studies, Female, Genotype, Humans, Intraocular Pressure, Male, Middle Aged, Sex Factors, Caveolin 1 genetics, Caveolin 2 genetics, Genomic Structural Variation, Glaucoma, Open-Angle genetics, Polymorphism, Single Nucleotide, Vision Disorders genetics, Visual Fields
Abstract

Purpose: The CAV1/CAV2 (caveolin 1 and caveolin 2) genomic region previously was associated with primary open-angle glaucoma (POAG), although replication among independent studies has been variable. The aim of this study was to assess the association between CAV1/CAV2 single nucleotide polymorphisms (SNPs) and POAG in a large case-control dataset and to explore associations by gender and pattern of visual field (VF) loss further., Design: Case-control study., Participants: We analyzed 2 large POAG data sets: the Glaucoma Genes and Environment (GLAUGEN) study (976 cases, 1140 controls) and the National Eye Institute Glaucoma Human Genetics Collaboration (NEIGHBOR) consortium (2132 cases, 2290 controls)., Methods: We studied the association between 70 SNPs located within the CAV1/CAV2 genomic region in the GLAUGEN and NEIGHBOR studies, both genotyped on the Illumina Human 660WQuadv1C BeadChip array and imputed with the Markov Chain Haplotyping algorithm using the HapMap 3 reference panel. We used logistic regression models of POAG in the overall population and separated by gender, as well as by POAG subtypes defined by type of VF defect (peripheral or paracentral). Results from GLAUGEN and NEIGHBOR were meta-analyzed, and a Bonferroni-corrected significance level of 7.7 × 10(-4) was used to account for multiple comparisons., Main Outcome Measures: Overall POAG, overall POAG by gender, and POAG subtypes defined by pattern of early VF loss., Results: We found significant associations between 10 CAV1/CAV2 SNPs and POAG (top SNP, rs4236601; pooled P = 2.61 × 10(-7)). Of these, 9 were significant only in women (top SNP, rs4236601; pooled P = 1.59 × 10(-5)). Five of the 10 CAV1/CAV2 SNPs were associated with POAG with early paracentral VF (top SNP, rs17588172; pooled P = 1.07 × 10(-4)), and none of the 10 were associated with POAG with peripheral VF loss only or POAG among men., Conclusions: CAV1/CAV2 SNPs were associated significantly with POAG overall, particularly among women. Furthermore, we found an association between CAV1/CAV2 SNPs and POAG with paracentral VF defects. These data support a role for caveolin 1, caveolin 2, or both in POAG and suggest that the caveolins particularly may affect POAG pathogenesis in women and in patients with early paracentral VF defects., (Copyright © 2014 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved.)

Published
2014
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38. Demographic and geographic features of exfoliation glaucoma in 2 United States-based prospective cohorts.

Author

Kang JH, Loomis S, Wiggs JL, Stein JD, and Pasquale LR

Subjects
Adult, Age Factors, Aged, Body Constitution, Exfoliation Syndrome diagnosis, Eye Color, Family Health, Female, Follow-Up Studies, Geography, Glaucoma diagnosis, Health Personnel, Humans, Intraocular Pressure, Male, Middle Aged, Prospective Studies, Racial Groups, Risk Factors, Sex Factors, United States epidemiology, Exfoliation Syndrome epidemiology, Glaucoma epidemiology
Abstract

Purpose: To examine prospectively the association between demographic and geographic factors in relation to exfoliation glaucoma (EG) or exfoliation glaucoma suspect (EGS)., Design: Prospective cohort study., Participants: Seventy-eight thousand nine hundred fifty-five women in the Nurses' Health Study and 41 191 men in the Health Professionals Follow-up Study., Methods: Female and male health professionals were followed prospectively from 1980 through 2008 and from 1986 through 2008, respectively. Eligible participants were 40 years of age or older, did not have EG or EGS at baseline, and reported undergoing eye examinations during follow-up. Information regarding demographic features, lifetime geographic residence, and potential confounders was collected. During follow-up, 348 EG or EGS cases were confirmed with medical record review. The relative risk of EG or EGS in each cohort was estimated separately and the results were pooled with meta-analysis., Main Outcome Measures: Multivariate rate ratios (MVRRs) of EG or EGS and their 95% confidence intervals (CIs)., Results: Exfoliation glaucoma or EGS was strongly age related with subjects 75 years of age or older at 46.22-fold (95% CI, 22.77-93.80) increased risk compared with those between 40 and 55 years of age. Although men were 68% less likely to develop EG or EGS than women (MVRR, 0.32; 95% CI, 0.23-0.46), no predisposition to EG or EGS by ancestry, particularly Scandinavian ancestry, emerged. Compared with a lifetime of living in the northern tier of the continental United States, lifetime residence in the middle geographic tier (MVRR, 0.53; 95% CI, 0.40-0.71) and in the southern geographic tier (MVRR, 0.25; 95% CI, 0.09-0.71) was associated with markedly reduced risks of EG or EGS., Conclusions: In this mainly white cohort from the United States, increasing age and female gender were significant risk factors for EG or EGS; however, Scandinavian heritage was not. Living in the middle or southern regions of the United States relative to living in the northern region was associated with a reduced risk of EG or EGS., Financial Disclosure(s): The author(s) have no proprietary or commercial interest in any materials discussed in this article., (Copyright © 2012 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved.)

Published
2012
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