Search

Your search keyword '"Wen‐Chih Wu"' showing total 11 results
Start Over Author "Wen‐Chih Wu" Publisher elsevier
11 results on '"Wen‐Chih Wu"'

1. Adversities in childhood and young adulthood and incident cardiovascular diseases: a prospective cohort studyResearch in context

Author

Xia Zou, Junfei Zhao, Anping Feng, Kei Hang Katie Chan, Wen-Chih Wu, JoAnn E. Manson, Simin Liu, and Jie Li

Subjects
Cardiovascular diseases, Adverse experience, Childhood, Adulthood, Lifestyle, Medicine (General), R5-920
Abstract

Summary: Background: Much remains unknown regarding the associations of adversities in childhood and adulthood with incident cardiovascular diseases (CVD). We aimed to examine the independent and cumulative relations of adversities in childhood and adulthood with incident CVD and whether these associations can be mitigated by adopting a healthy lifestyle later in life. Methods: We included 136,073 men and women [38–72 years at baseline] free of diagnosed CVD at baseline who responded to surveys on adversities in childhood and adulthood in the United Kingdom Biobank prospective cohort. They were recruited between 2006 and 2010 and were followed-up until 28 January 2021. Adversities included physical abuse, emotional abuse, sexual abuse, emotional neglect, and physical neglect. Participants were categorised into four groups according to the exposure periods, which were no adversity, childhood adversity only, adulthood adversity only, and cumulative adversity (both childhood and adulthood). The primary outcomes included incident fatal and non-fatal CVD events. The modifiable lifestyle factors were smoking, physical activity, diet, sleeping, social or leisure activities, and friend or family visits. Findings: We identified 16,415 (10.71/1000 person-year) incident CVD during a median follow-up of 11.8 years. Compared with participants with no adversity, CVD incidence increased by 11% in those with childhood adversity only (adjusted hazard ratio [HR]: 1.11 [95% CI 1.06–1.17], p

Published
2024
Full Text
View/download PDF

3. Ledipasvir/sofosbuvir for HCV genotype 1, 2, 4–6 infection: Real-world evidence from a nationwide registry in Taiwan

Author

Ching-Chu Lo, Chung-Feng Huang, Pin-Nan Cheng, Kuo-Chih Tseng, Chi-Yi Chen, Hsing-Tao Kuo, Yi-Hsiang Huang, Chi-Ming Tai, Cheng-Yuan Peng, Ming-Jong Bair, Chien-Hung Chen, Ming-Lun Yeh, Chih-Lang Lin, Chun-Yen Lin, Pei-Lun Lee, Lee-Won Chong, Chao-Hung Hung, Te Sheng Chang, Jee-Fu Huang, Chi-Chieh Yang, Jui-Ting Hu, Chih-Wen Lin, Chun-Ting Chen, Chia-Chi Wang, Wei-Wen Su, Tsai-Yuan Hsieh, Chih-Lin Lin, Wei-Lun Tsai, Tzong-Hsi Lee, Guei-Ying Chen, Szu-Jen Wang, Chun-Chao Chang, Lein-Ray Mo, Sheng-Shun Yang, Wen-Chih Wu, Chia-Sheng Huang, Chou-Kwok Hsiung, Chien-Neng Kao, Pei-Chien Tsai, Chen-Hua Liu, Mei-Hsuan Lee, Chun-Jen Liu, Chia-Yen Dai, Wan-Long Chuang, Han-Chieh Lin, Jia-Horng Kao, and Ming-Lung Yu

Subjects
Direct-acting antiviral, Hepatitis C virus, Ledipasvir, Real-world, Sofosbuvir, Medicine (General), R5-920
Abstract

Background/purpose: The Taiwan Association for the Study of the Liver (TASL) HCV Registry (TACR) is a nationwide registry of chronic hepatitis C patients in Taiwan. This study evaluated antiviral effectiveness of ledipasvir (LDV)/sofosbuvir (SOF) in patients in the TACR. Methods: Patients enrolled in TACR from 2017–2020 treated with LDV/SOF were eligible. The primary outcome was the proportion of patients with sustained virologic response 12 weeks after end of treatment (SVR12). Results: 5644 LDV/SOF ± ribavirin-treated patients were included (mean age: 61.4 years; 54.4% female). Dominant viral genotypes were GT1 (50.8%) and GT2 (39.3%). 1529 (27.1%) patients had liver cirrhosis, including 201 (3.6%) with liver decompensation; 686 (12.2%) had chronic kidney disease. SVR12 was achieved in 98.6% of the overall population and in 98.2% and 98.7% of patients with and without cirrhosis, respectively. SVR12 rates in patients with compensated cirrhosis treated with LDV/SOF without RBV were >98%, regardless of prior treatment experience. SVR12 was 98.6%, 98.4%, 100%, 100%, and 98.7% among those with GT1, GT2, GT4, GT5, and GT6 infections, respectively. Although patient numbers were relatively small, SVR12 rates of 100% were reported in patients infected with HCV GT2, GT5, and GT6 with decompensated cirrhosis and 98% in patients with severely compromised renal function. LDV/SOF adherence ≤60% (P

Published
2022
Full Text
View/download PDF

4. Adiposity, aldosterone and plasma renin activity among African Americans: The Jackson Heart Study

Author

Grace Lee, Bjorn Kluwe, Songzhu Zhao, David Kline, Divya Nedungadi, Guy N. Brock, James B. Odei, Veena Kesireddy, Neal Pohlman, Mario Sims, Valery S. Effoe, Wen-Chih Wu, Rita R. Kalyani, Gary S. Wand, Justin Echouffo-Tcheugui, Sherita H. Golden, and Joshua J. Joseph

Subjects
Renin, Aldosterone, Adipose tissue, African Americans, Diseases of the endocrine glands. Clinical endocrinology, RC648-665
Abstract

Objective: To analyze associations between adiposity and the renin-angiotensin-aldosterone system (RAAS) in a large African American (AA) cohort. Methods: Cross-sectional associations of adiposity (body mass index [BMI], waist circumference [WC], waist:height ratio, waist:hip ratio, leptin, adiponectin, leptin:adiponectin ratio [LAR], subcutaneous [SAT] and visceral adipose tissue [VAT], and liver attenuation [LA]) with aldosterone, plasma renin activity (renin), and aldosterone:renin ratio (ARR) were assessed in the Jackson Heart Study using adjusted linear regression models. Results: A 1-SD higher BMI was associated with a 4.8 % higher aldosterone, 9.4 % higher renin, and 5.0 % lower ARR (all p

Published
2023
Full Text
View/download PDF

5. Two decade trends in cardiovascular disease outcomes and cardiovascular risk factors among US veterans living with HIV

Author

Mohammed Haji, Vrishali V. Lopes, Augustus Ge, Christopher Halladay, Cullen Soares, Nishant R. Shah, Christopher T. Longenecker, Michelle Lally, Gerald S. Bloomfield, Theresa I. Shireman, David Ross, Jennifer L. Sullivan, James L. Rudolph, Wen-Chih Wu, and Sebhat Erqou

Subjects
HIV, Human immunodeficiency virus, Cardiovascular disease, CVD, Risk factors, Trend, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Coomprhensive data on temporal trends in cardiovascular disease (CVD) risk factors and outcomes in people living with HIV are limited. Using retrospective data on 50,284 US Veterans living with HIV (VLWH) who received care in the VA from 2001 to 2019, we calculated the prevalence and incidence estimates of CVD risk factors and outcomes, as well as the average annual percent changes (AAPC) in the estimates. The mean age of the Veterans increased from 47.8 (9.1) years to 58.0 (12.4) years during the study period. The population remained predominantly (>95%) male and majority Black (∼50%). The prevalence of the CVD outcomes increased progressively over the study period: coronary artery disease (3.9%–18.7%), peripheral artery disease (2.3%, 10.3%), ischemic cerebrovascular disease (1.1%–9.9%), and heart failure (2.4%–10.5%). There was a progressive increase in risk factor burden, except for smoking which declined after 2015. The AAPC in prevalence was statistically significant for the CVD outcomes and risk factors. When adjusted for age, the predicted prevalence of CVD risk factors and outcomes showed comparable (but attenuated) trends. There was generally a comparable (but attenuated) trend in incidence of CVD outcomes, procedures, and risk factors over the study period. The use of statins increased from 10.6% (2001) to 40.8% (2019). Antiretroviral therapy usage increased from 77.7% (2001) to 85.0% (2019). In conclusion, in a retrospective analysis of large-scale VA data we found the burden and incidence of several CVD risk factors and outcomes have increased among VLWH over the past 20 years.

Published
2022
Full Text
View/download PDF

6. Association between obesity phenotypes of insulin resistance and risk of type 2 diabetes in African Americans: The Jackson Heart Study

Author

Sean Lee, Mary E. Lacy, Mathew Jankowich, Adolfo Correa, and Wen-Chih Wu

Subjects
Diseases of the endocrine glands. Clinical endocrinology, RC648-665
Abstract

Objective: To determine whether insulin resistance (IR) measured by homeostasis model of insulin resistance (HOMA-IR) can further stratify diabetes risk in African Americans (AAs) beyond obesity and identify obese, low risk and non-obese, high risk individuals. Methods: Using the Jackson Heart Study cohort, we categorized participants without diabetes into four phenotypes: non-obese/insulin-sensitive, non-obese/IR, obese/insulin-sensitive and obese/IR. Obesity was defined as BMI ≥ 30 or BMI 25–30 plus an increased waist circumference. IR was defined as HOMA-IR ≥ 2. We used modified Poisson regression models to estimate the incident risk-ratios (IRR) of diabetes across these phenotypes adjusting for potential confounders and HbA1c. Results: Among 3219 AAs without diabetes, 14.0% were non-obese/insulin-sensitive, 24.6% non-obese/IR, 6.2% obese/insulin-sensitive, and 55.3% obese/IR. The overall crude incidence rate of diabetes was 29.91 cases/1000 person-years. In fully-adjusted models, compared to the non-obese/insulin-sensitive group, the relative risk of diabetes was highest in obese/IR (IRR = 2.35; 95% CI: 1.53, 3.60), followed by non-obese/IR (IRR = 1.59; 95% CI: 1.02, 2.46), and non-significant for the obese/insulin-sensitive (IRR = 1.70; 95% CI: 0.97, 2.99) group. Conclusions: HOMA-IR can further stratify diabetes risk in AA adults beyond obesity, identifying non-obese high-risk and lower-risk obese individuals. However, diabetes risk should still be carefully monitored in obese populations despite insulin sensitivity. Keywords: Overweight, Adiposity, Insulin sensitivity, Diabetes mellitus, Black race

Published
2020
Full Text
View/download PDF

7. Pathophysiologic relationship between Alzheimer's disease, cerebrovascular disease, and cardiovascular risk: A review and synthesis

Author

Peter J. Snyder, Jessica Alber, Mia Zhang, Ana Echeverria, Cláudia Y. Santos, and Wen-Chih Wu

Subjects
0301 basic medicine, medicine.medical_specialty, Population, Disease, Special Section: Vascular Contributions to Alzheimer's Disease, Pathogenesis, 03 medical and health sciences, 0302 clinical medicine, Epidemiology, medicine, Dementia, Intensive care medicine, Psychiatry, education, Cerebrovascular disease, education.field_of_study, business.industry, Incidence (epidemiology), Alzheimer's disease, VCID, medicine.disease, Cardiovascular disease, Psychiatry and Mental health, 030104 developmental biology, Vascular contributions to cognitive impairment and dementia, Risk factors, Etiology, Life expectancy, Neurology (clinical), business, 030217 neurology & neurosurgery
Abstract

As the population ages due to demographic trends and gains in life expectancy, the incidence and prevalence of dementia increases, and the need to understand the etiology and pathogenesis of dementia becomes ever more urgent. Alzheimer's disease (AD), the most common form of dementia, is a complex disease, the mechanisms of which are poorly understood. The more we learn about AD, the more questions are raised about our current conceptual models of disease. In the absence of a cure or the means by which to slow disease progress, it may be prudent to apply our current knowledge of the intersection between AD, cardiovascular disease, and cerebrovascular disease to foster efforts to delay or slow the onset of AD. This review discusses our current understanding of the epidemiology, genetics, and pathophysiology of AD, the intersection between AD and vascular causes of dementia, and proposes future directions for research and prevention.

Published
2017

8. Contributors

Author

SONYA S. ABDEL-RAZEQ, ABDULRAHMAN ABDULBAKI, WAFFIYAH AFRIDI, MONZR M. AL MALKI, TANYA ALI, PHILIP J. ALIOTTA, RUBEN ALVERO, SRIVIDYA ANANDAN, MEL L. ANDERSON, KATHRYN TAYLOR ANILOWSKI, MICHELLE STOZEK ANVAR, ETSUKO AOKI, NICOLE APPELLE, WISSAM S.Z. ASFAHANI, DANIEL K. ASIEDU, SUDEEP KAUR AULAKH, CRISOSTOMO R. BALIOG, PRIYA BANSAL, KRISHNA BARADHI, ROWLAND P. BARRETT, KERRI BATRA, VIKRAM BEHERA, OMRI BERGER, ARNALDO A. BERGES, SETH A. BERKOWITZ, JAYDEEP BHAT, HARIKRASHNA BHATT, COURTNEY CLARK BILODEAU, KENNETH D. BISHOP, MICHAEL BLUNDIN, SHEENAGH M. BODKIN, NIRALI BORA, JEFFREY M. BORKAN, ALEXANDRA BOSKE, LYNN BOWLBY, MARK F. BRADY, MANDEEP K. BRAR, ELIZABETH J. BROWN, GAVIN BROWN, JENNIFER BUCKLEY, JONATHAN BURNS, D. BRANDON BURTIS, DOUGLAS BURTT, STEVEN BUSSELEN, CLAUDIA RODRIGUEZ CABRERA, NIDA CHAUDHARY, VICKY CHENG, GAURAV CHOUDHARY, STEPHANIE W. CHOW, LISA COHEN, SCOTT COHEN, KAILA COMPTON, MARIA A. CORIGLIANO, BRIAN J. COWLES, DAN A. CRISTESCU, PATRICIA CRISTOFARO, ALICIA J. CURTIN, KRISTY L. DALRYMPLE, GEORGE T. DANAKAS, ALEXANDRA DEGENHARDT, JOSEPH A. DIAZ, JIMMY DIEP, MICHAEL R. DOBBS, NATHALIA DOOBAY, WILLIAM F. DOTSON, ANDREW DUKER, STUART J. EISENDRATH, PAMELA ELLSWORTH, HODA ELTOMI, PATRICIO SEBASTIAN ESPINOSA, VALERIA FABRE, MARK J. FAGAN, GIL M. FARKASH, TIMOTHY W. FARRELL, MITCHELL D. FELDMAN, FRED F. FERRI, GLEN FINNEY, STACI A. FISCHER, MARLENE FISHMAN, TAMARA G. FONG, PHILIP FORMICA, FRANK G. FORT, GLENN G. FORT, DAVID J. FORTUNATO, GREGORY K. FRITZ, SAINATH GADDAM, GENNA GEKHT, PAUL F. GEORGE, ANNGENE A. GIUSTOZZI, CINDY GLEIT, RICHARD J. GOLDBERG, ALLA GOLDBURT, GEETHA GOPALAKRISHNAN, PAUL GORDON, NANCY R. GRAFF, JOHN A. GRAY, ELLIOTT M. GROVES, PAVAN GUPTA, PRIYA SARIN GUPTA, NAWAZ HACK, WILLIAM O. HAHN, HARALD ALEXANDER HALL, MICHELE HALPERN, SAJEEV HANDA, TAYLOR HARRISON, DON HAYES, N. WILSON HOLLAND, SUSIE L. HU, ANNE L. HUME, HARKAWAL S. HUNDAL, SHARLISA HUTSON, SARAH M. HYDER, RICHARD S. ISAACSON, AHMAD M. ISMAIL, MATTHEW D. JANKOWICH, NOEL S.C. JAVIER, JENNIFER JEREMIAH, MICHAEL P. JOHNSON, BREE JOHNSTON, KIMBERLY JONES, KOHAR JONES, LUCY KALANITHI, EMILY R. KATZ, ALI KAZIM, BROOKE E. KEELEY, KARA A. KENNEDY, BEVIN KENNEY, LARA KFOURY, JIWON KIM, WAN J. KIM, ROBERT M. KIRCHNER, MICHAEL KLEIN, MELVYN KOBY, ROBERT KOHN, ARAVIND RAO KOKKIRALA, KENNETH KORR, KRISTINA KRAMER, DAVID KURSS, CINDY LAI, EDWARD V. LALLY, QUANG P. LE, KACHIU LEE, MARGARET LEKANDER, MATTHEW A. LEVINE, DONITA DILLON LIGHTNER, CHUN LIM, CUI LI LIN, RICHARD LONG, ELIZABETH A. LOWENHAUPT, ZEINA W. MAANI, SUSANNA R. MAGEE, ACHRAF A. MAKKI, ATIZAZUL H. MANSOOR, DOUGLAS W. MARTIN, ELISABETH B. MATSON, DANIEL T. MATTSON, KATE MAVRICH, ALISON C. MAY, LAUREN MAY, MAITREYI MAZUMDAR, JEFFREY C. McCLEAN, KELLY A. McGARRY, LYNN McNICOLL, LAURA H. McPEAKE, AKANKSHA MEHTA, DANIEL E. MENDEZ-ALLWOOD, LONNIE R. MERCIER, DENNIS J. MIKOLICH, THERESA A. MORGAN, NADIA MUJAHID, VINCENT A. MUKKADA, BILAL H. NAQVI, JACK H. NASSAU, JUDY NEE, TAKUMA NEMOTO, JAMES J. NG, MELISSA NOTHNAGLE, BETH NOWAK, GAIL M. O’BRIEN, CAROLYN J. O’CONNOR, ALEXANDER B. OLAWAIYE, MICHAEL K. ONG, STEVEN M. OPAL, JOSEPH R. OWENS, CHRISTINA ANTONIO PACHECO, ROBERTO PACHECO, JANICE PATACSIL-TRULL, BIRJU B. PATEL, PRANAV M. PATEL, ELENI PATROZOU, ALISON PATTERSON, STEVEN PELIGIAN, HEIDI H. PETERSON, KATHARINE A. PHILLIPS, PAUL A. PIRRAGLIA, WENDY A. PLANTE, ANGELA M. PLETTE, SHARON S. HARTMAN POLENSEK, SAMUEL H. POON, DONN POSNER, ARUNDATHI G. PRASAD, AMANDA PRESSMAN, KITTICHAI PROMRAT, SHAHNAZ PUNJANI, IFAD U. RAHMAN, RADHIKA A. RAMANAN, CHRISTIAN N. RAMSEY, WASIM RASHID, RICHARD REGNANTE, VICTOR I. REUS, HARLAN G. RICH, JESSICA RISSER, RACHEL ROACH, LUTHER K. ROBINSON, JAMISON ROGERS, ANISHKA S. ROLLE, JULIE L. ROTH, LAUREN ROTH, AMITY RUBEOR, IMMAD SADIQ, NUHA R. SAID, BHARATH SATHYA, HEMANT K. SATPATHY, RUBY K. SATPATHY, JASON M. SATTERFIELD, SEAN I. SAVITZ, SYEDA M. SAYEED, PETER J. SELL, CATHERINE SHAFTS, MADHAVI SHAH, GRACE SHIH, ASHA SHRESTHA, MARK SIGMAN, JOANNE M. SILVIA, DIVYA SINGHAL, JOHN SLADKY, JEANETTE G. SMITH, U. SHIVRAJ SOHUR, DIVJOT SOOCH, HEATHER SUNTER, MARY BETH SUTTER, JULIE ANNE SZUMIGALA, DOMINICK TAMMARO, SARAH TAPYRIK, GLADYS TELANG, TAHIR TELLIOGLU, IRIS L. TONG, ALEXANDER G. TRUESDELL, MARGARET TRYFOROS, JOSEPH RALPH TUCCI, EROBOGHENE E. UBOGU, SEAN H. UITERWYK, NICOLE J. ULLRICH, MARISA E. VAN POZNAK, NITANTH R. VANGALA, JORGE A. VILLAFUERTE, TARA M. WAYT, DENNIS M. WEPPNER, JORDAN WHITE, LAUREL M. WHITE, HILARY B. WHITLACH, MATTHEW P. WICKLUND, AMANDA WOJTUSIK, CHARLES WOLFF, MARIE ELIZABETH WONG, WEN-CHIH WU, WEN Y. (HELENA) WU-CHEN, BETH J. WUTZ, SARAH L. XAVIER, AUGUSTIN G. YIP, JOHN Q. YOUNG, CANDICE YUVIENCO, CINDY ZADIKOFF, FARIHA ZAHEER, MARK ZIMMERMAN, BERNARD ZIMMERMANN, SCOTT J. ZUCCALA, and RYAN W. ZUZEK

Published
2013

9. Section editors

Author

RUBEN ALVERO, JEFFREY M. BORKAN, MICHAEL R. DOBBS, FRED F. FERRI, GLENN G. FORT, RICHARD J. GOLDBERG, HARALD ALEXANDER HALL, DENNIS J. MIKOLICH, IRIS L. TONG, and WEN-CHIH WU

Published
2013

10. Contributors

Author

Sonya S. Abdel-Razeq, Tanya Ali, Philip J. Aliotta, George O. Alonso, Ruben Alvero, Srividya Anandan, Mel L. Anderson, Michelle Stozek Anvar, Etsuko Aoki, Vasanthi Arumugam, Sudeep Kaur Aulakh, Michael Benatar, Sheenagh M. Bodkin, Lynn Bowlby, Joanna Brown, Jonathan Burns, Gaurav Choudhary, Maria A. Corigliano, John E. Croom, George T. Danakas, Alexandra Degenhardt, Joseph A. Diaz, Christine M. Duffy, Jane V. Eason, Mark J. Fagan, Gil M. Farkash, Timothy W. Farrell, Christopher A. Ferri, Vito F. Ferri, Tamara G. Fong, Glenn G. Fort, Genna Gekht, Paul F. George, David R. Gifford, Cindy Gleit, Rebecca A. Griffith, Joseph F. Grillo, Michele Halpern, Mustafa A. Hammad, Sajeev Handa, Alex Harrison, Taylor Harrison, Christine Healy, Jennifer Roh Hur, Richard S. Isaacson, Jennifer Jeremiah, Michael P. Johnson, Powel H. Kazanjian, Joseph J. Lieber, Mara Linscott, Zeena Lobo, Michael Maher, Achraf A. Makki, Joseph R. Masci, Daniel T. Mattson, Kelly A. McGarry, Lynn McNicoll, Lonnie R. Mercier, Dennis J. Mikolich, Takuma Nemoto, Melissa Nothnagle, Gail M. O’Brien, Carolyn J. O’Connor, Steven M. Opal, Mina B. Pantcheva, Pranav M. Patel, Peter Petropoulos, Paul A. Pirraglia, Sharon S. Hartman Polensek, Maurice Policar, Arundathi G. Prasad, Kittichai Promrat, John Ragsdale, Chaitanya V. Reddy, Harlan G. Rich, Hemant K. Satpathy, Ruby Satpathy, Sean I. Savitz, Jack L. Schwartzwald, Harvey M. Shanies, Deborah L. Shapiro, Grace Shih, Joanne M. Silvia, U. Shivraj Sohur, Dominick Tammaro, Iris Tong, Margaret Tryforos, Eroboghene E. Ubogu, Tom J. Wachtel, Tara M. Wayt, Marc S. Weinberg, Dennis M. Weppner, Wen-Chih Wu, Beth J. Wutz, Cindy Zadikoff, and Scott J. Zuccala

Published
2011

11. Contributors

Author

Philip J. Aliotta, George O. Alonso, Susan Berner, Lynn Bowlby, John E. Croom, Claudia L. Dade, George T. Danakas, Mark J. Fagan, Mitchell D. Feldman, Fred F. Ferri, Marsha D. Fretwell, Michael P. Gerardo, Cynthia Holzer, Richard S. Isaacson, E. Gordon Margolin, Peter S. Margolis, Daniel T. Mattson, Lynn McNicoll, Lonnie R. Mercier, Arvind Modawal, John B. Murphy, Aman Nanda, Pranav M. Patel, Sean I. Savitz, Clifford Milo Singer, Michael D. Stein, Laura Trice, Eroboghene E. Ubogu, Tom J. Wachtel, Deborah Adams Wingate, Wen-Chih Wu, and Beth J. Wutz

Published
2007

Catalog

Books, media, physical & digital resources
See catalog results