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Publisher Summary The dorsal-column medial-lemniscal (DCML) system has its first and most important synaptic station in the dorsal column nuclei. It is phylogenetically the most recent of the three systems and has been traditionally viewed as an exclusive, homogeneous, fast, and high-safety system for relaying somatic sensory information from peripheral mechanoreceptors to the thalamocortical levels. The closely related spino-cervico-lemniscal system involves two spinal synaptic stations in succession (the dorsal horn gray and the lateral cervical nucleus) before relaying the crossed information towards areas near and similar to those of the DCML system in the thalamus and cortex. The third or ventral column system is the oldest phylogenetically. It lacks a precise definition; however, it encompasses a larger central nervous system representation and includes several components, most of which have slow and low-safety transmission across the successive relays. Its peripheral axons innervate mechanoreceptors, thermoreceptors, and nociceptors. The axons of second order neurons in the dorsal gray of the spinal cord ascend crossed and/or uncrossed through several routes before reaching several supra-spinal structures.