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193 results on '"Vaughan P"'

1. How do cemented short Exeter stems perform compared with standard-length Exeter stems? The experience of the New Zealand National Joint Registry

Author: Michael C. Wyatt, FRACS, Vaughan Poutawera, FRACS, David C. Kieser, PhD, FRACS, Chris M.A. Frampton, PhD, and Gary J. Hooper, MD, FRACS
Subjects: Orthopedic surgery, RD701-811
Abstract: Background: The standard Exeter (Stryker) cemented stem is 150 mm long with standard offsets ranging from 37.5 mm to 56 mm. Exeter short stems of 125 mm are also available in the offsets of 37.5 mm, 44 mm, and 50 mm. In addition, smaller (125 mm or shorter) Exeter cemented stems with offsets of 35.5 mm or less are available. The aim of this study was to examine the New Zealand Joint Registry (NZJR) comparing medium-term survival rates and functional outcomes of standard-length stems with Exeter short stems of various offsets in patients undergoing primary total hip replacement. Methods: Using the NZJR, we compared the results of 3 separate groups of patients with Exeter stems. Patients with standard 150 mm length Exeter stems (Standard) were compared with patients with Exeter 125 mm stems with regular 37.5 mm, 44 mm, and 50 mm offsets (Short 37+) and Exeter 125 mm stems with offsets of 35.5 mm and below (Short 37−). Demographic data, preoperative diagnosis, patient-reported outcome measures, and reasons for revision were compared between groups. Kaplan-Meier survival analysis and Cox multivariate regression analysis were used to examine implant survival and the influence of stem group on revision rates adjusting for gender, age, diagnosis, and surgical approach. Results: There were 43,427 Exeter cemented stems in the NZJR between January 1, 1999 and 31, May 2018; 41,629 Standard, 657 Short 37+, and 1501 Short 37−. In all 3 groups, the posterior surgical approach was preferred (Standard, 76.1%; Short 37+, 94.6%; Short 37−, 76.6%; P < .001). In the Short 37− group, 94.1% were female, while in the other 2 groups, there was an equal gender ratio (P < .001). The Short 37- group was also significantly younger than the other 2 groups with 41.6% younger than 65 years compared with Short 37+ (37.2%) and Standard groups (36.9%) (P < .01). There was no difference in American Society of Anesthesiologists grade between groups. Body mass index (BMI) was significantly higher in both the Short 37− and Short 37 + groups compared with the Standard group (Standard BMI, 28.71; SD 5.72; Short 37+ BMI, 29.69; SD, 6.67; Short 37− BMI, 29.09; SD 7.07; P < .001). The all-cause revision rate for standard stems was 0.55/100 component years (cy) (95% CI: 0.52 to 0.58). The Short 37− group had a higher rate of revision compared with the Standard group (hazard ratio 1.6; 95% CI: 1.3 to 1.98; P < .001), while the Short 37+ group had a hazard ratio of 0.84 (95% CI: 0.38 to 1.88; P = .674) compared with the Standard group. Cox regression analysis controlling for age, gender, diagnosis of OA, and surgical approach did not affect these findings. However, no clinically meaningful difference between Oxford hip scores was observed. Conclusions: There was a significant difference in revision rates for aseptic loosening with standard-length Exeter stems having a lower revision rate than short Exeter stems with offsets 35.5 mm or less. The Short 37+ groups, despite comprising relatively small numbers, performed similarly to the Standard stem group. Keywords: Exeter, Short stem, Registry, Offset, Survivorship, Function
Published: 2020
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2. Integrated top-down process and voxel-based microstructure modeling for Ti-6Al-4V in laser wire direct energy deposition process

Author: Yousub Lee, Peeyush Nandwana, Brian Gibson, Paritosh Mhatre, Julio Ortega Rojas, Bhagyashree Prabhune, Aaron Thornton, Joshua Vaughan, and Srdjan Simunovic
Subjects: Additive manufacturing, Microstructure, Ti-6Al-4V, Top-down process modeling, Voxel-based microstructure modeling, Gaussian Process, Materials of engineering and construction. Mechanics of materials, TA401-492
Abstract: Laser-wire metal additive manufacturing (AM) is one of the ideal direct energy deposition (DED) processes for creating large-scale parts with a medium level of complexity. However, the DED process involves complex thermal signatures and wide length scales making the fabrication of realistic AM components and part qualification often reliant on experimental trial-and-error optimization. While experimental measurements over the full volume of a part are valuable and necessary, measuring the entire area of a part is significantly laborious and practically infeasible, particularly for large parts in terms of cost and rapid qualification. Therefore, in this work, we developed an effective thermal and microstructure modeling framework based on the Johnson–Mehl-Avrami-Kolmogorov (JMAK) and Koistinen & Marburger (KM) models through a top-down approach that considers plate distortion-affected thermal profiles. A voxel-by-voxel simulation method is used to predict individual phase fractions of Ti-6Al-4 V. The predicted results were validated through detailed metallurgical measurements. A combined voxel-by-voxel approach with a sparse data reconstruction technique produced a near-perfect reconstruction of the original data. This approach anticipates a significant reduction in data points and computation time and resources. Lastly, we conclude with potential extensions of this work to other modeling efforts.
Published: 2024
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3. Bipartition of the atlanto-occipital joint surfaces in a South African sample

Author: Vaughan Thompson, Caroline Hay, Christopher Yelverton, and Nicolene Jooste
Subjects: Anatomical variation, Joint bipartition, Occipital condyle, Superior articular facet of the atlas, South Africa, Human anatomy, QM1-695
Abstract: Background: One variation of the atlanto-occipital joint contains a groove or crest dividing the superior articulating facet of C1 and/or the corresponding occipital condyle. This study aimed to estimate the prevalence of bipartition of the facets associated with the atlanto-occipital joint and to determine the relationships between the corresponding joint surfaces, bilateral and unilateral facets as well as demographic factors in a South African sample. Materials and methods: Data about shape and bipartition found on the superior articular facets of the atlas and the occipital condyles were collected from 109 skulls and atlases from the Pretoria Bone Collection, South Africa. Shape data was categorically classified according to existing criteria from literature. Results: The results revealed the occasional occurrence of a double facet at both the superior articular facet of the atlas (15.6 %), and the occipital condyle (7.34 %). Shape and facet number of the superior articulating facet and corresponding occipital condyle were significantly correlated. The prevalence of bipartition of neither the superior articular facets nor the occipital condyles were statistically significantly different between the left and right sides. Sex and age did not statistically significantly contribute to prevalence of bipartition in this population. However, population group statistically significantly contributed to prevalence of bipartition (p = 0.019), with the White South African sample having a much higher prevalence (88.24 % superior articulating facet, 100 % occipital condyle) of bipartition compared to the Black South African sample (11.76 % superior articular facet, 0 % occipital condyle). Conclusion: Awareness of this joint variation and instances where it is more likely to occur may be valuable for neuro-vascular and orthopaedic surgeons when doing invasive treatments around the craniocervical junction, and chiropractors when assessing and treating patients.
Published: 2024
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4. Search for pair production of boosted Higgs bosons via vector-boson fusion in the bb¯bb¯ final state using pp collisions at s=13TeV with the ATLAS detector

Author: G. Aad, E. Aakvaag, B. Abbott, S. Abdelhameed, K. Abeling, N.J. Abicht, S.H. Abidi, M. Aboelela, A. Aboulhorma, H. Abramowicz, H. Abreu, Y. Abulaiti, B.S. Acharya, A. Ackermann, C. Adam Bourdarios, L. Adamczyk, S.V. Addepalli, M.J. Addison, J. Adelman, A. Adiguzel, T. Adye, A.A. Affolder, Y. Afik, M.N. Agaras, J. Agarwala, A. Aggarwal, C. Agheorghiesei, A. Ahmad, F. Ahmadov, W.S. Ahmed, S. Ahuja, X. Ai, G. Aielli, A. Aikot, M. Ait Tamlihat, B. Aitbenchikh, M. Akbiyik, T.P.A. Åkesson, A.V. Akimov, D. Akiyama, N.N. Akolkar, S. Aktas, K. Al Khoury, G.L. Alberghi, J. Albert, P. Albicocco, G.L. Albouy, S. Alderweireldt, Z.L. Alegria, M. Aleksa, I.N. Aleksandrov, C. Alexa, T. Alexopoulos, F. Alfonsi, M. Algren, M. Alhroob, B. Ali, H.M.J. Ali, S. Ali, S.W. Alibocus, M. Aliev, G. Alimonti, W. Alkakhi, C. Allaire, B.M.M. Allbrooke, J.F. Allen, C.A. Allendes Flores, P.P. Allport, A. Aloisio, F. Alonso, C. Alpigiani, Z.M.K. Alsolami, M. Alvarez Estevez, A. Alvarez Fernandez, M. Alves Cardoso, M.G. Alviggi, M. Aly, Y. Amaral Coutinho, A. Ambler, C. Amelung, M. Amerl, C.G. Ames, D. Amidei, K.J. Amirie, S.P. Amor Dos Santos, K.R. Amos, S. An, V. Ananiev, C. Anastopoulos, T. Andeen, J.K. Anders, A.C. Anderson, S.Y. Andrean, A. Andreazza, S. Angelidakis, A. Angerami, A.V. Anisenkov, A. Annovi, C. Antel, E. Antipov, M. Antonelli, F. Anulli, M. Aoki, T. Aoki, M.A. Aparo, L. Aperio Bella, C. Appelt, A. Apyan, S.J. Arbiol Val, C. Arcangeletti, A.T.H. Arce, E. Arena, J-F. Arguin, S. Argyropoulos, J.-H. Arling, O. Arnaez, H. Arnold, G. Artoni, H. Asada, K. Asai, S. Asai, N.A. Asbah, R.A. Ashby Pickering, K. Assamagan, R. Astalos, K.S.V. Astrand, S. Atashi, R.J. Atkin, M. Atkinson, H. Atmani, P.A. Atmasiddha, K. Augsten, S. Auricchio, A.D. Auriol, V.A. Austrup, G. Avolio, K. Axiotis, G. Azuelos, D. Babal, H. Bachacou, K. Bachas, A. Bachiu, F. Backman, A. Badea, T.M. Baer, P. Bagnaia, M. Bahmani, D. Bahner, K. Bai, J.T. Baines, L. Baines, O.K. Baker, E. Bakos, D. Bakshi Gupta, L.E. Balabram Filho, V. Balakrishnan, R. Balasubramanian, E.M. Baldin, P. Balek, E. Ballabene, F. Balli, L.M. Baltes, W.K. Balunas, J. Balz, I. Bamwidhi, E. Banas, M. Bandieramonte, A. Bandyopadhyay, S. Bansal, L. Barak, M. Barakat, E.L. Barberio, D. Barberis, M. Barbero, M.Z. Barel, K.N. Barends, T. Barillari, M-S. Barisits, T. Barklow, P. Baron, D.A. Baron Moreno, A. Baroncelli, G. Barone, A.J. Barr, J.D. Barr, F. Barreiro, J. Barreiro Guimarães da Costa, U. Barron, M.G. Barros Teixeira, S. Barsov, F. Bartels, R. Bartoldus, A.E. Barton, P. Bartos, A. Basan, M. Baselga, A. Bassalat, M.J. Basso, S. Bataju, R. Bate, R.L. Bates, S. Batlamous, B. Batool, M. Battaglia, D. Battulga, M. Bauce, M. Bauer, P. Bauer, L.T. Bazzano Hurrell, J.B. Beacham, T. Beau, J.Y. Beaucamp, P.H. Beauchemin, P. Bechtle, H.P. Beck, K. Becker, A.J. Beddall, V.A. Bednyakov, C.P. Bee, L.J. Beemster, T.A. Beermann, M. Begalli, M. Begel, A. Behera, J.K. Behr, J.F. Beirer, F. Beisiegel, M. Belfkir, G. Bella, L. Bellagamba, A. Bellerive, P. Bellos, K. Beloborodov, D. Benchekroun, F. Bendebba, Y. Benhammou, K.C. Benkendorfer, L. Beresford, M. Beretta, E. Bergeaas Kuutmann, N. Berger, B. Bergmann, J. Beringer, G. Bernardi, C. Bernius, F.U. Bernlochner, F. Bernon, A. Berrocal Guardia, T. Berry, P. Berta, A. Berthold, S. Bethke, A. Betti, A.J. Bevan, N.K. Bhalla, S. Bhatta, D.S. Bhattacharya, P. Bhattarai, K.D. Bhide, V.S. Bhopatkar, R.M. Bianchi, G. Bianco, O. Biebel, R. Bielski, M. Biglietti, C.S. Billingsley, M. Bindi, A. Bingul, C. Bini, A. Biondini, G.A. Bird, M. Birman, M. Biros, S. Biryukov, T. Bisanz, E. Bisceglie, J.P. Biswal, D. Biswas, I. Bloch, A. Blue, U. Blumenschein, J. Blumenthal, V.S. Bobrovnikov, M. Boehler, B. Boehm, D. Bogavac, A.G. Bogdanchikov, C. Bohm, V. Boisvert, P. Bokan, T. Bold, M. Bomben, M. Bona, M. Boonekamp, C.D. Booth, A.G. Borbély, I.S. Bordulev, H.M. Borecka-Bielska, G. Borissov, D. Bortoletto, D. Boscherini, M. Bosman, J.D. Bossio Sola, K. Bouaouda, N. Bouchhar, L. Boudet, J. Boudreau, E.V. Bouhova-Thacker, D. Boumediene, R. Bouquet, A. Boveia, J. Boyd, D. Boye, I.R. Boyko, L. Bozianu, J. Bracinik, N. Brahimi, G. Brandt, O. Brandt, F. Braren, B. Brau, J.E. Brau, R. Brener, L. Brenner, R. Brenner, S. Bressler, G. Brianti, D. Britton, D. Britzger, I. Brock, R. Brock, G. Brooijmans, E.M. Brooks, E. Brost, L.M. Brown, L.E. Bruce, T.L. Bruckler, P.A. Bruckman de Renstrom, B. Brüers, A. Bruni, G. Bruni, M. Bruschi, N. Bruscino, T. Buanes, Q. Buat, D. Buchin, A.G. Buckley, O. Bulekov, B.A. Bullard, S. Burdin, C.D. Burgard, A.M. Burger, B. Burghgrave, O. Burlayenko, J.T.P. Burr, J.C. Burzynski, E.L. Busch, V. Büscher, P.J. Bussey, J.M. Butler, C.M. Buttar, J.M. Butterworth, W. Buttinger, C.J. Buxo Vazquez, A.R. Buzykaev, S. Cabrera Urbán, L. Cadamuro, D. Caforio, H. Cai, Y. Cai, V.M.M. Cairo, O. Cakir, N. Calace, P. Calafiura, G. Calderini, P. Calfayan, G. Callea, L.P. Caloba, D. Calvet, S. Calvet, M. Calvetti, R. Camacho Toro, S. Camarda, D. Camarero Munoz, P. Camarri, M.T. Camerlingo, D. Cameron, C. Camincher, M. Campanelli, A. Camplani, V. Canale, A.C. Canbay, E. Canonero, J. Cantero, Y. Cao, F. Capocasa, M. Capua, A. Carbone, R. Cardarelli, J.C.J. Cardenas, G. Carducci, T. Carli, G. Carlino, J.I. Carlotto, B.T. Carlson, E.M. Carlson, J. Carmignani, L. Carminati, A. Carnelli, M. Carnesale, S. Caron, E. Carquin, S. Carrá, G. Carratta, A.M. Carroll, T.M. Carter, M.P. Casado, M. Caspar, F.L. Castillo, L. Castillo Garcia, V. Castillo Gimenez, N.F. Castro, A. Catinaccio, J.R. Catmore, T. Cavaliere, V. Cavaliere, N. Cavalli, L.J. Caviedes Betancourt, Y.C. Cekmecelioglu, E. Celebi, S. Cella, F. Celli, M.S. Centonze, V. Cepaitis, K. Cerny, A.S. Cerqueira, A. Cerri, L. Cerrito, F. Cerutti, B. Cervato, A. Cervelli, G. Cesarini, S.A. Cetin, D. Chakraborty, J. Chan, W.Y. Chan, J.D. Chapman, E. Chapon, B. Chargeishvili, D.G. Charlton, M. Chatterjee, C. Chauhan, Y. Che, S. Chekanov, S.V. Chekulaev, G.A. Chelkov, A. Chen, B. Chen, H. Chen, J. Chen, M. Chen, S. Chen, S.J. Chen, X. Chen, Y. Chen, C.L. Cheng, H.C. Cheng, S. Cheong, A. Cheplakov, E. Cheremushkina, E. Cherepanova, R. Cherkaoui El Moursli, E. Cheu, K. Cheung, L. Chevalier, V. Chiarella, G. Chiarelli, N. Chiedde, G. Chiodini, A.S. Chisholm, A. Chitan, M. Chitishvili, M.V. Chizhov, K. Choi, Y. Chou, E.Y.S. Chow, K.L. Chu, M.C. Chu, X. Chu, Z. Chubinidze, J. Chudoba, J.J. Chwastowski, D. Cieri, K.M. Ciesla, V. Cindro, A. Ciocio, F. Cirotto, Z.H. Citron, M. Citterio, D.A. Ciubotaru, A. Clark, P.J. Clark, N. Clarke Hall, C. Clarry, J.M. Clavijo Columbie, S.E. Clawson, C. Clement, J. Clercx, Y. Coadou, M. Cobal, A. Coccaro, R.F. Coelho Barrue, R. Coelho Lopes De Sa, S. Coelli, B. Cole, J. Collot, P. Conde Muiño, M.P. Connell, S.H. Connell, E.I. Conroy, F. Conventi, H.G. Cooke, A.M. Cooper-Sarkar, F.A. Corchia, A. Cordeiro Oudot Choi, L.D. Corpe, M. Corradi, F. Corriveau, A. Cortes-Gonzalez, M.J. Costa, F. Costanza, D. Costanzo, B.M. Cote, J. Couthures, G. Cowan, K. Cranmer, D. Cremonini, S. Crépé-Renaudin, F. Crescioli, M. Cristinziani, M. Cristoforetti, V. Croft, J.E. Crosby, G. Crosetti, A. Cueto, H. Cui, Z. Cui, W.R. Cunningham, F. Curcio, J.R. Curran, P. Czodrowski, M.M. Czurylo, M.J. Da Cunha Sargedas De Sousa, J.V. Da Fonseca Pinto, C. Da Via, W. Dabrowski, T. Dado, S. Dahbi, T. Dai, D. Dal Santo, C. Dallapiccola, M. Dam, G. D'amen, V. D'Amico, J. Damp, J.R. Dandoy, D. Dannheim, M. Danninger, V. Dao, G. Darbo, S.J. Das, F. Dattola, S. D'Auria, A. D'avanzo, C. David, T. Davidek, I. Dawson, H.A. Day-hall, K. De, R. De Asmundis, N. De Biase, S. De Castro, N. De Groot, P. de Jong, H. De la Torre, A. De Maria, A. De Salvo, U. De Sanctis, F. De Santis, A. De Santo, J.B. De Vivie De Regie, D.V. Dedovich, J. Degens, A.M. Deiana, F. Del Corso, J. Del Peso, F. Del Rio, L. Delagrange, F. Deliot, C.M. Delitzsch, M. Della Pietra, D. Della Volpe, A. Dell'Acqua, L. Dell'Asta, M. Delmastro, P.A. Delsart, S. Demers, M. Demichev, S.P. Denisov, L. D'Eramo, D. Derendarz, F. Derue, P. Dervan, K. Desch, C. Deutsch, F.A. Di Bello, A. Di Ciaccio, L. Di Ciaccio, A. Di Domenico, C. Di Donato, A. Di Girolamo, G. Di Gregorio, A. Di Luca, B. Di Micco, R. Di Nardo, K.F. Di Petrillo, M. Diamantopoulou, F.A. Dias, T. Dias Do Vale, M.A. Diaz, F.G. Diaz Capriles, M. Didenko, E.B. Diehl, S. Díez Cornell, C. Diez Pardos, C. Dimitriadi, A. Dimitrievska, J. Dingfelder, I-M. Dinu, S.J. Dittmeier, F. Dittus, M. Divisek, F. Djama, T. Djobava, C. Doglioni, A. Dohnalova, J. Dolejsi, Z. Dolezal, K. Domijan, K.M. Dona, M. Donadelli, B. Dong, J. Donini, A. D'Onofrio, M. D'Onofrio, J. Dopke, A. Doria, N. Dos Santos Fernandes, P. Dougan, M.T. Dova, A.T. Doyle, M.A. Draguet, E. Dreyer, I. Drivas-koulouris, M. Drnevich, M. Drozdova, D. Du, T.A. du Pree, F. Dubinin, M. Dubovsky, E. Duchovni, G. Duckeck, O.A. Ducu, D. Duda, A. Dudarev, E.R. Duden, M. D'uffizi, L. Duflot, M. Dührssen, I. Duminica, A.E. Dumitriu, M. Dunford, S. Dungs, K. Dunne, A. Duperrin, H. Duran Yildiz, M. Düren, A. Durglishvili, B.L. Dwyer, G.I. Dyckes, M. Dyndal, B.S. Dziedzic, Z.O. Earnshaw, G.H. Eberwein, B. Eckerova, S. Eggebrecht, E. Egidio Purcino De Souza, L.F. Ehrke, G. Eigen, K. Einsweiler, T. Ekelof, P.A. Ekman, S. El Farkh, Y. El Ghazali, H. El Jarrari, A. El Moussaouy, V. Ellajosyula, M. Ellert, F. Ellinghaus, N. Ellis, J. Elmsheuser, M. Elsawy, M. Elsing, D. Emeliyanov, Y. Enari, I. Ene, S. Epari, P.A. Erland, D. Ernani Martins Neto, M. Errenst, M. Escalier, C. Escobar, E. Etzion, G. Evans, H. Evans, L.S. Evans, A. Ezhilov, S. Ezzarqtouni, F. Fabbri, L. Fabbri, G. Facini, V. Fadeyev, R.M. Fakhrutdinov, D. Fakoudis, S. Falciano, L.F. Falda Ulhoa Coelho, F. Fallavollita, G. Falsetti, J. Faltova, C. Fan, Y. Fan, Y. Fang, M. Fanti, M. Faraj, Z. Farazpay, A. Farbin, A. Farilla, T. Farooque, S.M. Farrington, F. Fassi, D. Fassouliotis, M. Faucci Giannelli, W.J. Fawcett, L. Fayard, P. Federic, P. Federicova, O.L. Fedin, M. Feickert, L. Feligioni, D.E. Fellers, C. Feng, M. Feng, Z. Feng, M.J. Fenton, L. Ferencz, R.A.M. Ferguson, S.I. Fernandez Luengo, P. Fernandez Martinez, M.J.V. Fernoux, J. Ferrando, A. Ferrari, P. Ferrari, R. Ferrari, D. Ferrere, C. Ferretti, D. Fiacco, F. Fiedler, P. Fiedler, A. Filipčič, E.K. Filmer, F. Filthaut, M.C.N. Fiolhais, L. Fiorini, W.C. Fisher, T. Fitschen, P.M. Fitzhugh, I. Fleck, P. Fleischmann, T. Flick, M. Flores, L.R. Flores Castillo, L. Flores Sanz De Acedo, F.M. Follega, N. Fomin, J.H. Foo, A. Formica, A.C. Forti, E. Fortin, A.W. Fortman, M.G. Foti, L. Fountas, D. Fournier, H. Fox, P. Francavilla, S. Francescato, S. Franchellucci, M. Franchini, S. Franchino, D. Francis, L. Franco, V. Franco Lima, L. Franconi, M. Franklin, G. Frattari, Y.Y. Frid, J. Friend, N. Fritzsche, A. Froch, D. Froidevaux, J.A. Frost, Y. Fu, S. Fuenzalida Garrido, M. Fujimoto, K.Y. Fung, E. Furtado De Simas Filho, M. Furukawa, J. Fuster, A. Gaa, A. Gabrielli, P. Gadow, G. Gagliardi, L.G. Gagnon, S. Gaid, S. Galantzan, E.J. Gallas, B.J. Gallop, K.K. Gan, S. Ganguly, Y. Gao, F.M. Garay Walls, B. Garcia, C. García, A. Garcia Alonso, A.G. Garcia Caffaro, J.E. García Navarro, M. Garcia-Sciveres, G.L. Gardner, R.W. Gardner, N. Garelli, D. Garg, R.B. Garg, J.M. Gargan, C.A. Garner, C.M. Garvey, V.K. Gassmann, G. Gaudio, V. Gautam, P. Gauzzi, J. Gavranovic, I.L. Gavrilenko, A. Gavrilyuk, C. Gay, G. Gaycken, E.N. Gazis, A.A. Geanta, C.M. Gee, A. Gekow, C. Gemme, M.H. Genest, A.D. Gentry, S. George, W.F. George, T. Geralis, P. Gessinger-Befurt, M.E. Geyik, M. Ghani, K. Ghorbanian, A. Ghosal, A. Ghosh, B. Giacobbe, S. Giagu, T. Giani, P. Giannetti, A. Giannini, S.M. Gibson, M. Gignac, D.T. Gil, A.K. Gilbert, B.J. Gilbert, D. Gillberg, G. Gilles, L. Ginabat, D.M. Gingrich, M.P. Giordani, P.F. Giraud, G. Giugliarelli, D. Giugni, F. Giuli, I. Gkialas, L.K. Gladilin, C. Glasman, G.R. Gledhill, G. Glemža, M. Glisic, I. Gnesi, Y. Go, M. Goblirsch-Kolb, B. Gocke, D. 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Privara, T. Procter, M.L. Proffitt, N. Proklova, K. Prokofiev, G. Proto, J. Proudfoot, M. Przybycien, W.W. Przygoda, A. Psallidas, J.E. Puddefoot, D. Pudzha, D. Pyatiizbyantseva, J. Qian, D. Qichen, Y. Qin, T. Qiu, A. Quadt, M. Queitsch-Maitland, G. Quetant, R.P. Quinn, G. Rabanal Bolanos, D. Rafanoharana, F. Raffaeli, F. Ragusa, J.L. Rainbolt, J.A. Raine, S. Rajagopalan, E. Ramakoti, I.A. Ramirez-Berend, K. Ran, N.P. Rapheeha, H. Rasheed, V. Raskina, D.F. Rassloff, A. Rastogi, S. Rave, S. Ravera, B. Ravina, I. Ravinovich, M. Raymond, A.L. Read, N.P. Readioff, D.M. Rebuzzi, G. Redlinger, A.S. Reed, K. Reeves, J.A. Reidelsturz, D. Reikher, A. Rej, C. Rembser, M. Renda, M.B. Rendel, F. Renner, A.G. Rennie, A.L. Rescia, S. Resconi, M. Ressegotti, S. Rettie, J.G. Reyes Rivera, E. Reynolds, O.L. Rezanova, P. Reznicek, H. Riani, N. Ribaric, E. Ricci, R. Richter, S. Richter, E. Richter-Was, M. Ridel, S. Ridouani, P. Rieck, P. Riedler, E.M. Riefel, J.O. Rieger, M. Rijssenbeek, M. Rimoldi, L. Rinaldi, P. Rincke, T.T. Rinn, M.P. Rinnagel, G. Ripellino, I. Riu, J.C. Rivera Vergara, F. Rizatdinova, E. Rizvi, B.R. Roberts, S.H. Robertson, D. Robinson, C.M. Robles Gajardo, M. Robles Manzano, A. Robson, A. Rocchi, C. Roda, S. Rodriguez Bosca, Y. Rodriguez Garcia, A. Rodriguez Rodriguez, A.M. Rodríguez Vera, S. Roe, J.T. Roemer, A.R. Roepe-Gier, J. Roggel, O. Røhne, R.A. Rojas, C.P.A. Roland, J. Roloff, A. Romaniouk, E. Romano, M. Romano, A.C. Romero Hernandez, N. Rompotis, L. Roos, S. Rosati, B.J. Rosser, E. Rossi, L.P. Rossi, L. Rossini, R. Rosten, M. Rotaru, B. Rottler, C. Rougier, D. Rousseau, D. Rousso, A. Roy, S. Roy-Garand, A. Rozanov, Z.M.A. Rozario, Y. Rozen, A. Rubio Jimenez, A.J. Ruby, V.H. Ruelas Rivera, T.A. Ruggeri, A. Ruggiero, A. Ruiz-Martinez, A. Rummler, Z. Rurikova, N.A. Rusakovich, H.L. Russell, G. Russo, J.P. Rutherfoord, S. Rutherford Colmenares, M. Rybar, E.B. Rye, A. Ryzhov, J.A. Sabater Iglesias, P. Sabatini, H.F-W. Sadrozinski, F. Safai Tehrani, B. Safarzadeh Samani, S. Saha, M. Sahinsoy, A. Saibel, M. Saimpert, M. Saito, T. Saito, A. Sala, D. Salamani, A. Salnikov, J. Salt, A. Salvador Salas, D. Salvatore, F. Salvatore, A. Salzburger, D. Sammel, E. Sampson, D. Sampsonidis, D. Sampsonidou, J. Sánchez, V. Sanchez Sebastian, H. Sandaker, C.O. Sander, J.A. Sandesara, M. Sandhoff, C. Sandoval, L. Sanfilippo, D.P.C. Sankey, T. Sano, A. Sansoni, L. Santi, C. Santoni, H. Santos, A. Santra, E. Sanzani, K.A. Saoucha, J.G. Saraiva, J. Sardain, O. Sasaki, K. Sato, C. Sauer, E. Sauvan, P. Savard, R. Sawada, C. Sawyer, L. Sawyer, C. Sbarra, A. Sbrizzi, T. Scanlon, J. Schaarschmidt, U. Schäfer, A.C. Schaffer, D. Schaile, R.D. Schamberger, C. Scharf, M.M. Schefer, V.A. Schegelsky, D. Scheirich, M. Schernau, C. Scheulen, C. Schiavi, M. Schioppa, B. Schlag, K.E. Schleicher, S. Schlenker, J. Schmeing, M.A. Schmidt, K. Schmieden, C. Schmitt, N. Schmitt, S. Schmitt, L. Schoeffel, A. Schoening, P.G. Scholer, E. Schopf, M. Schott, J. Schovancova, S. Schramm, T. Schroer, H-C. Schultz-Coulon, M. Schumacher, B.A. Schumm, Ph. Schune, A.J. Schuy, H.R. Schwartz, A. Schwartzman, T.A. Schwarz, Ph. Schwemling, R. Schwienhorst, F.G. Sciacca, A. Sciandra, G. Sciolla, F. Scuri, C.D. Sebastiani, K. Sedlaczek, S.C. Seidel, A. Seiden, B.D. Seidlitz, C. Seitz, J.M. Seixas, G. Sekhniaidze, L. Selem, N. Semprini-Cesari, D. Sengupta, V. Senthilkumar, L. Serin, M. Sessa, H. Severini, F. Sforza, A. Sfyrla, Q. Sha, E. Shabalina, A.H. Shah, R. Shaheen, J.D. Shahinian, D. Shaked Renous, L.Y. Shan, M. Shapiro, A. Sharma, A.S. Sharma, P. Sharma, P.B. Shatalov, K. Shaw, S.M. Shaw, Q. Shen, D.J. Sheppard, P. Sherwood, L. Shi, X. Shi, C.O. Shimmin, J.D. Shinner, I.P.J. Shipsey, S. Shirabe, M. Shiyakova, M.J. Shochet, J. Shojaii, D.R. Shope, B. Shrestha, S. Shrestha, M.J. Shroff, P. Sicho, A.M. Sickles, E. Sideras Haddad, A.C. Sidley, A. Sidoti, F. Siegert, Dj. Sijacki, F. Sili, J.M. Silva, I. Silva Ferreira, M.V. Silva Oliveira, S.B. Silverstein, S. Simion, R. Simoniello, E.L. Simpson, H. Simpson, L.R. Simpson, N.D. Simpson, S. Simsek, S. Sindhu, P. Sinervo, S. Singh, S. Sinha, M. Sioli, I. Siral, E. Sitnikova, J. Sjölin, A. Skaf, E. Skorda, P. Skubic, M. Slawinska, V. Smakhtin, B.H. Smart, S.Yu. Smirnov, Y. Smirnov, L.N. Smirnova, O. Smirnova, A.C. Smith, D.R. Smith, E.A. Smith, H.A. Smith, J.L. Smith, R. Smith, M. Smizanska, K. Smolek, A.A. Snesarev, S.R. Snider, H.L. Snoek, S. Snyder, R. Sobie, A. Soffer, C.A. Solans Sanchez, E.Yu. Soldatov, U. Soldevila, A.A. Solodkov, S. Solomon, A. Soloshenko, K. Solovieva, O.V. Solovyanov, P. Sommer, A. Sonay, W.Y. Song, A. Sopczak, A.L. Sopio, F. Sopkova, J.D. Sorenson, I.R. Sotarriva Alvarez, V. Sothilingam, O.J. Soto Sandoval, S. Sottocornola, R. Soualah, Z. Soumaimi, D. South, N. Soybelman, S. Spagnolo, M. Spalla, D. Sperlich, G. Spigo, S. Spinali, B. Spisso, D.P. Spiteri, M. Spousta, E.J. Staats, R. Stamen, A. Stampekis, M. Standke, E. Stanecka, W. Stanek-Maslouska, M.V. Stange, B. Stanislaus, M.M. Stanitzki, B. Stapf, E.A. Starchenko, G.H. Stark, J. Stark, P. Staroba, P. Starovoitov, S. Stärz, R. Staszewski, G. Stavropoulos, J. Steentoft, A. Stefl, P. Steinberg, B. Stelzer, H.J. Stelzer, O. Stelzer-Chilton, H. Stenzel, T.J. Stevenson, G.A. Stewart, J.R. Stewart, M.C. Stockton, G. Stoicea, M. Stolarski, S. Stonjek, A. Straessner, J. Strandberg, S. Strandberg, M. Stratmann, M. Strauss, T. Strebler, P. Strizenec, R. Ströhmer, D.M. Strom, R. Stroynowski, A. Strubig, S.A. Stucci, B. Stugu, J. Stupak, N.A. Styles, D. Su, S. Su, W. Su, X. Su, D. Suchy, K. Sugizaki, V.V. Sulin, M.J. Sullivan, D.M.S. Sultan, L. Sultanaliyeva, S. Sultansoy, T. Sumida, S. Sun, O. Sunneborn Gudnadottir, N. Sur, M.R. Sutton, H. Suzuki, M. Svatos, M. Swiatlowski, T. Swirski, I. Sykora, M. Sykora, T. Sykora, D. Ta, K. Tackmann, A. Taffard, R. Tafirout, J.S. Tafoya Vargas, Y. Takubo, M. Talby, A.A. Talyshev, K.C. Tam, N.M. Tamir, A. Tanaka, J. Tanaka, R. Tanaka, M. Tanasini, Z. Tao, S. Tapia Araya, S. Tapprogge, A. Tarek Abouelfadl Mohamed, S. Tarem, K. Tariq, G. Tarna, G.F. Tartarelli, M.J. Tartarin, P. Tas, M. Tasevsky, E. Tassi, A.C. Tate, G. Tateno, Y. Tayalati, G.N. Taylor, W. Taylor, R. Teixeira De Lima, P. Teixeira-Dias, J.J. Teoh, K. Terashi, J. Terron, S. Terzo, M. Testa, R.J. Teuscher, A. Thaler, O. Theiner, N. Themistokleous, T. Theveneaux-Pelzer, O. Thielmann, D.W. Thomas, J.P. Thomas, E.A. Thompson, P.D. Thompson, E. Thomson, R.E. Thornberry, C. Tian, Y. Tian, V. Tikhomirov, Yu.A. Tikhonov, S. Timoshenko, D. Timoshyn, E.X.L. Ting, P. Tipton, A. Tishelman-Charny, S.H. Tlou, K. Todome, S. Todorova-Nova, S. Todt, L. Toffolin, M. Togawa, J. Tojo, S. Tokár, K. Tokushuku, O. Toldaiev, R. Tombs, M. Tomoto, L. Tompkins, K.W. Topolnicki, E. Torrence, H. Torres, E. Torró Pastor, M. Toscani, C. Tosciri, M. Tost, D.R. Tovey, I.S. Trandafir, T. Trefzger, A. Tricoli, I.M. Trigger, S. Trincaz-Duvoid, D.A. Trischuk, B. Trocmé, A. Tropina, L. Truong, M. Trzebinski, A. Trzupek, F. Tsai, M. Tsai, A. Tsiamis, P.V. Tsiareshka, S. Tsigaridas, A. Tsirigotis, V. Tsiskaridze, E.G. Tskhadadze, M. Tsopoulou, Y. Tsujikawa, I.I. Tsukerman, V. Tsulaia, S. Tsuno, K. Tsuri, D. Tsybychev, Y. Tu, A. Tudorache, V. Tudorache, A.N. Tuna, S. Turchikhin, I. Turk Cakir, R. Turra, T. Turtuvshin, P.M. Tuts, S. Tzamarias, E. Tzovara, F. Ukegawa, P.A. Ulloa Poblete, E.N. Umaka, G. Unal, A. Undrus, G. Unel, J. Urban, P. Urrejola, G. Usai, R. Ushioda, M. Usman, Z. Uysal, V. Vacek, B. Vachon, T. Vafeiadis, A. Vaitkus, C. Valderanis, E. Valdes Santurio, M. Valente, S. Valentinetti, A. Valero, E. Valiente Moreno, A. Vallier, J.A. Valls Ferrer, D.R. Van Arneman, T.R. Van Daalen, A. Van Der Graaf, P. Van Gemmeren, M. Van Rijnbach, S. Van Stroud, I. Van Vulpen, P. Vana, M. Vanadia, W. Vandelli, E.R. Vandewall, D. Vannicola, L. Vannoli, R. Vari, E.W. Varnes, C. Varni, T. Varol, D. Varouchas, L. Varriale, K.E. Varvell, M.E. Vasile, L. Vaslin, G.A. Vasquez, A. Vasyukov, L.M. Vaughan, R. Vavricka, T. Vazquez Schroeder, J. Veatch, V. Vecchio, M.J. Veen, I. Veliscek, L.M. Veloce, F. Veloso, S. Veneziano, A. Ventura, S. Ventura Gonzalez, A. Verbytskyi, M. Verducci, C. Vergis, M. Verissimo De Araujo, W. Verkerke, J.C. Vermeulen, C. Vernieri, M. Vessella, M.C. Vetterli, A. Vgenopoulos, N. Viaux Maira, T. Vickey, O.E. Vickey Boeriu, G.H.A. Viehhauser, L. Vigani, M. Villa, M. Villaplana Perez, E.M. Villhauer, E. Vilucchi, M.G. Vincter, A. Visibile, C. Vittori, I. Vivarelli, E. Voevodina, F. Vogel, J.C. Voigt, P. Vokac, Yu. Volkotrub, J. Von Ahnen, E. Von Toerne, B. Vormwald, V. Vorobel, K. Vorobev, M. Vos, K. Voss, M. Vozak, L. Vozdecky, N. Vranjes, M. Vranjes Milosavljevic, M. Vreeswijk, N.K. Vu, R. Vuillermet, O. Vujinovic, I. Vukotic, S. Wada, C. Wagner, J.M. Wagner, W. Wagner, S. Wahdan, H. Wahlberg, M. Wakida, J. Walder, R. Walker, W. Walkowiak, A. Wall, E.J. Wallin, T. Wamorkar, A.Z. Wang, C. Wang, H. Wang, J. Wang, P. Wang, R. Wang, S.M. Wang, S. Wang, T. Wang, W.T. Wang, W. Wang, X. Wang, Y. Wang, Z. Wang, A. Warburton, R.J. Ward, N. Warrack, S. Waterhouse, A.T. Watson, H. Watson, M.F. Watson, E. Watton, G. Watts, B.M. Waugh, J.M. Webb, C. Weber, H.A. Weber, M.S. Weber, S.M. Weber, C. Wei, Y. Wei, A.R. Weidberg, E.J. Weik, J. Weingarten, C. Weiser, C.J. Wells, T. Wenaus, B. Wendland, T. Wengler, N.S. Wenke, N. Wermes, M. Wessels, A.M. Wharton, A.S. White, A. White, M.J. White, D. Whiteson, L. Wickremasinghe, W. Wiedenmann, M. Wielers, C. Wiglesworth, D.J. Wilbern, H.G. Wilkens, J.J.H. Wilkinson, D.M. Williams, H.H. Williams, S. Williams, S. Willocq, B.J. Wilson, P.J. Windischhofer, F.I. Winkel, F. Winklmeier, B.T. Winter, J.K. Winter, M. Wittgen, M. Wobisch, T. Wojtkowski, Z. Wolffs, J. Wollrath, M.W. Wolter, H. Wolters, M.C. Wong, E.L. Woodward, S.D. Worm, B.K. Wosiek, K.W. Woźniak, S. Wozniewski, K. Wraight, C. Wu, M. Wu, S.L. Wu, X. Wu, Y. Wu, Z. Wu, J. Wuerzinger, T.R. Wyatt, B.M. Wynne, S. Xella, L. Xia, M. Xia, J. Xiang, M. Xie, S. Xin, A. Xiong, J. Xiong, D. Xu, H. Xu, L. Xu, R. Xu, T. Xu, Y. Xu, Z. Xu, B. Yabsley, S. Yacoob, Y. Yamaguchi, E. Yamashita, H. Yamauchi, T. Yamazaki, Y. Yamazaki, J. Yan, S. Yan, Z. Yan, H.J. Yang, H.T. Yang, S. Yang, T. Yang, X. Yang, Y. Yang, Z. Yang, W-M. Yao, H. Ye, J. Ye, S. Ye, X. Ye, Y. Yeh, I. Yeletskikh, B. Yeo, M.R. Yexley, T.P. Yildirim, P. Yin, K. Yorita, S. Younas, C.J.S. Young, C. Young, C. Yu, Y. Yu, J. Yuan, M. Yuan, R. Yuan, L. Yue, M. Zaazoua, B. Zabinski, E. Zaid, Z.K. Zak, T. Zakareishvili, N. Zakharchuk, S. Zambito, J.A. Zamora Saa, J. Zang, D. Zanzi, O. Zaplatilek, C. Zeitnitz, H. Zeng, J.C. Zeng, D.T. Zenger, Jr, O. Zenin, T. Ženiš, S. Zenz, S. Zerradi, D. Zerwas, M. Zhai, D.F. Zhang, J. Zhang, K. Zhang, L. Zhang, P. Zhang, R. Zhang, S. Zhang, T. Zhang, X. Zhang, Y. Zhang, Z. Zhang, H. Zhao, T. Zhao, Y. Zhao, Z. Zhao, A. Zhemchugov, J. Zheng, K. Zheng, X. Zheng, Z. Zheng, D. Zhong, B. Zhou, H. Zhou, N. Zhou, Y. Zhou, C.G. Zhu, J. Zhu, X. Zhu, Y. Zhu, X. Zhuang, K. Zhukov, N.I. Zimine, J. Zinsser, M. Ziolkowski, L. Živković, A. Zoccoli, K. Zoch, T.G. Zorbas, O. Zormpa, W. Zou, and L. Zwalinski
Subjects: Physics, QC1-999
Abstract: A search for Higgs boson pair production via vector-boson fusion is performed in the Lorentz-boosted regime, where a Higgs boson candidate is reconstructed as a single large-radius jet, using 140 fb−1 of proton–proton collision data at s=13 TeV recorded by the ATLAS detector at the Large Hadron Collider. Only Higgs boson decays into bottom quark pairs are considered. The search is particularly sensitive to the quartic coupling between two vector bosons and two Higgs bosons relative to its Standard Model prediction, κ2V. This study constrains κ2V to 0.55
Published: 2024
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5. The role of southern red-backed voles, Myodes gapperi, and Peromyscus mice in the enzootic maintenance of Lyme disease spirochetes in North Dakota, USA

Author: Michael W. Dougherty, Nathan M. Russart, Robert A. Gaultney, Emily M. Gisi, Haley M. Cooper, Lindsey R. Kallis, Catherine A. Brissette, and Jefferson A. Vaughan
Subjects: Lyme disease, Ixodes scapularis, Dermacentor variabilis, Peromyscus, Myodes gapperi, Reservoir potential, Infectious and parasitic diseases, RC109-216
Abstract: Lyme disease has expanded into the Great Plains of the USA. To investigate local enzootic transmission, small mammals were trapped in two forested tracts in northeastern North Dakota during 2012 and 2013. Peromyscus mice and southern red-backed voles, Myodes gapperi, comprised over 90% of all mammals captured. One site was dominated by Peromyscus (79% of 100 mammals captured). At the other site, M. gapperi (59% of 107 mammals captured) was more abundant than Peromyscus (36%). Immature stages of two tick species parasitized small mammals: Dermacentor variabilis and Ixodes scapularis. Larval I. scapularis ectoparasitism was significantly higher on Peromyscus (81% infested; 3.7 larvae per infested mouse) than M. gapperi (47% infested; 2.6 larvae per infested vole) whereas larval and nymphal D. variabilis ectoparasitism were highest on M. gapperi. Over 45% of infested rodents were concurrently infested with both tick species. Testing engorged I. scapularis larvae from Peromyscus (n = 66) and M. gapperi (n = 20) yielded xenopositivity prevalence for Borrelia burgdorferi sensu lato (s.l.) in these rodents of 6% and 5%, respectively. Progeny of field collected M. gapperi were used to determine host infectivity for a local isolate of B. burgdorferi sensu stricto (s.s.). Five M. gapperi were injected with spirochetes, infested with pathogen-free I. scapularis larvae on days 10, 20, and 40 after infection, and engorged larvae molted to nymphs. Subsamples of nymphs were tested by PCR for B. burgdorferi s. s. DNA and yielded infection rates of 56% (n = 100 nymphs tested), 75% (n = 8) and 64% (n = 31), respectively. The remaining infected nymphs were fed on BALB/c Mus musculus mice and 7 d later, mice were euthanized, and tissues were cultured for B. burgdorferi s.s. Nymphs successfully transmitted spirochetes to 13 of 18 (72%) mice that were exposed to 1–5 infected ticks. Theoretical reservoir potentials – i.e., ability to generate B. burgdorferi infected nymphs – were compared between Peromyscus and M. gapperi. At one site, Peromyscus accounted for nearly all Borrelia-infected nymphs produced (reservoir potential value of 0.935). At the other site, the reservoir potentials for Peromyscus (0.566) and M. gapperi (0.434) were comparable. The difference was attributed to differences in the relative abundance of voles versus mice between sites and the higher level of ectoparasitism by larval I. scapularis on Peromyscus versus M. gapperi at both sites. The southern red-backed vole, M. gapperi, contributes to the enzootic maintenance of Lyme disease spirochetes in North Dakota and possibly other areas where this rodent species is abundant.
Published: 2024
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6. Changes in blood pressure measurement prevalence among United States adults with hypertension before and during the COVID-19 pandemic

Author: Baffour Otchere, Adam S. Vaughan, LaTonia Richardson, Hilary K. Wall, and Fátima Coronado
Subjects: Hypertension, COVID-19, Self-measured blood pressure monitoring, Medicine
Abstract: Background: The Coronavirus Disease 2019 (COVID-19) pandemic disrupted health care, with particularly profound effects on persons with chronic conditions like hypertension. Objectives: In this study, we examined changes in the prevalence of blood pressure (BP) measurements by a healthcare professional among adults aged ≥ 18 years with hypertension before and during the COVID-19 pandemic in the United States (US). Methods: This study utilized the National Health Interview Survey data from April to December of the 2019 and 2021 modules of the survey. A total of 15,855 participants were included in the analytic sample. The prevalence of BP measurements taken by a health professional was calculated and the association between survey year and BP measurements was evaluated using adjusted and unadjusted logistic regression models. Results: Overall, the prevalence of BP measurements by a health professional among US adults with hypertension decreased from 95.9 % in the pre-pandemic period to 94.7 % in the pandemic period. Adults with hypertension were less likely (OR: 0.76, 95 % CI: 0.63–0.91) to report having had a BP measurement taken by a health professional during the pandemic compared to before the pandemic. Conclusion: Self-measured BP monitoring with clinical support could ensure continuous and improved care of individuals with hypertension, especially when circumstances could interrupt healthcare access.
Published: 2024
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7. Differential activation of lateral parabrachial nuclei and their limbic projections during head compared with body pain: A 7-Tesla functional magnetic resonance imaging study

Author: Rebecca V Robertson, Noemi Meylakh, Lewis S Crawford, Fernando A Tinoco Mendoza, Paul M Macey, Vaughan G Macefield, Kevin A Keay, and Luke A Henderson
Subjects: Brainstem, Parabrachial nucleus, Hypothalamus, Thalamus, Ultra-high field MRI, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract: Pain is a complex experience that involves sensory, emotional, and motivational components. It has been suggested that pain arising from the head and orofacial regions evokes stronger emotional responses than pain from the body. Indeed, recent work in rodents reports different patterns of activation in ascending pain pathways during noxious stimulation of the skin of the face when compared to noxious stimulation of the body. Such differences may dictate different activation patterns in higher brain regions, specifically in those areas processing the affective component of pain. We aimed to use ultra-high field functional magnetic resonance imaging (fMRI at 7-Tesla) to determine whether noxious thermal stimuli applied to the surface of the face and body evoke differential activation patterns within the ascending pain pathway in awake humans (n=16). Compared to the body, noxious heat stimulation to the face evoked more widespread signal changes in prefrontal cortical regions and numerous brainstem and subcortical limbic areas. Moreover, facial pain evoked significantly different signal changes in the lateral parabrachial nucleus, substantia nigra, paraventricular hypothalamus, and paraventricular thalamus, to those evoked by body pain. These results are consistent with recent preclinical findings of differential activation in the brainstem and subcortical limbic nuclei and associated cortices during cutaneous pain of the face when compared with the body. The findings suggest one potential mechanism by which facial pain could evoke a greater emotional impact than that evoked by body pain.
Published: 2024
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8. Hazardous wildfire smoke events can alter dawn soundscapes in dry forests of central and eastern Washington, United States

Author: Olivia V. Sanderfoot, Morgan W. Tingley, Sarah B. Bassing, Joseph K. Vaughan, Nicole A. June, and Beth Gardner
Subjects: Biophony, Ecoacoustics, Passive acoustic monitoring, Air pollution, AIRPACT, Ecology, QH540-549.5
Abstract: As global wildfire activity increases, wildlife are facing greater exposure to hazardous smoke pollution – with unknown consequences for biodiversity. Research on the effects of smoke on wild animals is extremely limited, in part due to the inherent logistical challenges of observing how animals respond to smoke in real time. Passive acoustic monitoring may be a powerful tool to safely and effectively monitor biodiversity before, during, and after major smoke events. In this study, we used data collected from a large-scale network of bioacoustic recorders at 92 sites in central and eastern Washington state during August–September, 2019–2020 to investigate the effect of wildfire smoke on dawn soundscapes and, by extension, acoustically active wildlife. We used acoustic indices to document and characterize changes in soundscapes related to smoke exposure, including the Acoustic Complexity Index (ACI), Bioacoustic Index (BI), and Normalized Difference Soundscape Index (NDSI). Higher values of these indices likely indicate higher levels of biodiversity in our study area. We hypothesized that wildfire smoke would reduce bird vocalizations, leading to declines in ACI, BI, and NDSI at dawn, when birds are most active. We used linear and quantile regression models to test for an effect of daily exposure to fine particulate matter (PM2.5), a marker of wildfire smoke, on the mean daily values and the upper 90th percentile of each index at dawn. We also conducted a before-during-after analysis of a particularly hazardous smoke event that impacted our study area on September 12–14, 2020. We did not observe linear effects of daily PM2.5 on average or peak daily values of acoustic indices; however, we did observe a significant reduction in ACI and BI during the three-day smoke event in 2020 and in the two weeks following this air pollution episode. Our results indicate that, on average, ACI and BI were reduced by 2.7 % and 15.9 % during and 1.5 % and 11.0 % afterward, respectively. These findings add further evidence that wildfire smoke alters soundscapes, likely due to changes in the presence, abundance, or behavior of acoustically active animals. Furthermore, our study demonstrates that wildfire smoke may have delayed and/or cumulative effects on acoustically active wildlife. Our study highlights the potential for passive acoustic monitoring to document wildlife responses to smoke pollution and identify potentially relevant exposure periods.
Published: 2024
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9. Growing and fostering knowledge translation: Recommendations for health organisations from the SPHERE Envisionarium

Author: Ann Dadich, Priya Vaughan, Chloe Watfern, Zoi Triandafilidis, Stephanie Habak, and Katherine M. Boydell
Subjects: Knowledge translation, Health networks, Health organisations, Envisionarium, Science (General), Q1-390, Social sciences (General), H1-99
Abstract: Objectives: Despite considerable investments in health research, there is a disconnect between what is known to enhance healthcare and how healthcare is delivered in situ. Knowledge translation (KT) plays a vital role in addressing this disconnect. Some governments promote KT via initiatives that encourage collaboration between researchers, clinicians, communities and others; this includes Maridulu Budyari Gumal SPHERE (Sydney Partnership for Health, Education, Research and Enterprise). To promote KT and address the knowledge-to-action gap, we held an envisionarium with SPHERE members, to generate recommendations to promote KT in, and beyond, SPHERE. Methods: To discern these recommendations, an envisionarium was facilitated with SPHERE members. Participants included researchers, healthcare providers and others (n = 16). Participants considered how KT can be fostered and promoted. Discussion notes and participant responses were thematically analysed. Results: Four recommendations were identified, accompanied by practical steps to action these to enable health and research institutions to foster KT. These include the need to: provide access to resources; reconceptualise impact and innovation; promote the legitimacy of different knowledges; and engage everyone in KT. Conclusions: These recommendations are important for three reasons. First, they demonstrate that KT requires more than funding – it also requires networks that buoy the dynamic flow of knowledge in its varied manifestations. Second, the recommendations demonstrate the importance of supportive organisational mechanisms that inculcate positive, KT-friendly structures or cultures, while affording individuals the opportunity to organically foster innovation. Third, they demonstrate the methodological value of envisionariums to disrupt the status quo and envision different ways to promote KT.
Published: 2024
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10. Post-acute COVID-19 outcomes including participant-reported long COVID: amubarvimab/romlusevimab versus placebo in the ACTIV-2 trialResearch in context

Author: Teresa H. Evering, Carlee Moser, Nikolaus Jilg, Justin Ritz, David A. Wohl, Jonathan Z. Li, David Margolis, Arzhang Cyrus Javan, Joseph J. Eron, Judith S. Currier, Eric S. Daar, Davey M. Smith, Michael D. Hughes, Kara W. Chew, Kara Chew, David (Davey) Smith, Eric Daar, David Wohl, Judith Currier, Joseph Eron, Michael Hughes, Mark Giganti, Lara Hosey, Jhoanna Roa, Nilam Patel, Kelly Colsh, Irene Rwakazina, Justine Beck, Scott Sieg, Jonathan Li, Courtney Fletcher, William Fischer, Rachel Bender Ignacio, Sandra Cardoso, Katya Corado, Prasanna Jagannathan, Alan Perelson, Sandy Pillay, Cynthia Riviere, Upinder Singh, Babafemi Taiwo, Joan Gottesman, Matthew Newell, Susan Pedersen, Joan Dragavon, Cheryl Jennings, Brian Greenfelder, William Murtaugh, Jan Kosmyna, Morgan Gapara, Akbar Shahkolahi, Verónica Lacal, Diego Salusso, Sebastian Nuñez, Marcelo Rodrigo Rodriguez, Luciana Laborde, Marcelo Papasidero, Luis Wehbe, Mariana Gonzalez, Felicitas Fernandez Voena, Tomas Alvarez, Amaru Lopez, Virginia Huhn, Ulises D'Andrea Nores, Pablo Dieser, Fernando Bordese, Marisa Mussi, Rodrigo de Carvalho Santana, Adriana Aparecida Tiraboschi Bárbaro, Breno Santos, Rita de Cássia Alves Lira, Andre Luiz Machado da Silva, Sandra Wagner Cardoso, Maria Pia Diniz Ribeiro, Nathália Soliva, Eduardo Vasconcellos, Jorge Eurico Ribeiro, Miriam Amaral Enéas, Jorge Pinto, Julia Fonseca de Morais Caporali, Flávia Gomes Faleiro Ferreira, Norma Erendira Rivera Martinez, Victor Casildo Bohorquez Lopez, Melchor Victor Frias, Krystle Fetalvero, Alyxzza Maranan, Jennifer Rosa, Thomas Coetzer, Maureen Mohata, Sr., Umesh Lalloo, Penelope Madlala, Larisha Pillay-Ramaya, Jaclyn Ann Bennet, Noluthando Mwelase, Nokuphiwa Mbhele, Frederick Petrick, Leonard Joubert, Rose Mbali, Sr., Natasha Joseph, Mmatsie Manentsa, Eugene van der Walt, Mduduzi Sandile Lawrance Masilela, Zinhle Zwane, Tendai Chiperera, Lerato Mohapi, Suri Moonsamy, Usha Singh, Kirsten McHarry, Elizma Snyman, Pieter Lennox, James Craig Innes, Oteng Letlape, Olebogeng Jonkane, William Brumskine, Tania Adonis, Ni Ni Sein, Modulakgotla Sebe, Yacoob Vahed, Nazreen Jeewa Hussen, Ismail Mitha, Vasundhara Cheekati, Purna Cheekati, Christie Lummus, Samuel Idarraga, Andrew Kim, David N. Pham, Wei-Hsin Kao, Michael M. Pfeffer, Miriam Batule Dominguez, Anju Malik, Anna Bryan, Melanie Arnold, Idania Fernandez, Cinzia Karpf, Aniuska Ruiz, David Taylor, Eric Folkens, Jennifer Manne, Sigal Yawetz, Cheryl Keenan, Emeka Eziri, Carl Fichtenbaum, Jenifer Baer, Sarah Trentman, Robert Call, Leroy Vaughan, Aaron Milstone, Jamie Alex Slandzicki, Jessica Wallan, Clinton Guillory, Nancy Andrews, Leslie Hughes, Jonathan Berardi, Celine Arar, Randall Quinn, Jorge P. Amaya, Marissa Gomez-Martinez, Luis Cantu, Monica Betancourt-Garcia, Nwora Lance Okeke, Charles M. Burns, Fadi Haddad, Victoria Haddad, Augusto Focil, Griselda Rosas, Susana Moyano, Yaneicy Gonzalez Rojas, Ahmad Aswad, Yevgeniy Bukhman, Manish Jain, Eugene Bukhman, Humam Farah, Rebekah McClain, Sadia Shaik, Timothy Hatlen, Deepa Gotur, Joseph Surber, Jeffrey Kingsley, April Pixler, Alex Zopo, Jack Herman, Craig Herman, Ramon Leon, Boris Nikolov, Fernando Gonzalez Vergara, Ana I. Gonzalez, Noemi Gonzalez, Michael Gelman, Olga Andriunas, Zarema Jagizarov, Jan Westerman, David Davis, Donna Sherer, Kelly Dooley, Becky Becker, Adaliah Wilkins, Jose Pérez, Eloy Roman, Heriberto Fernández, Bharat Mocherla, Kelly Beck, Valarie Maldonado, Jennifer Veltman, Rajesh Gandhi, Katrina Shea, Matthew Planchon, Laura Bogan Herpel, Kaushlendra K. Tripathi, Donald C. Day, John Pullman, Sr., Erin Williams-Leber, Misty Johnson, Michelle Hecker, Ann Avery, Keila Hoover, George W. Monlux, Elizabeth Juneja, Jr., Arthur Wernick, Karelia Ruiz, Maureen Hernández, Yadilys Pérez, Babafemi O. Taiwo, Claudia Hawkins, Baiba Berzins, Carlos Malvestutto, Heather Harber, Robyn Cicarella, Edwin DeJesus, Charlotte-Paige Rolle, Almena L. Free, Sallie D. Pulliam, Debra Weinstein, Rosa M. Suarez, Ezequiel Socorro, Estefania Socorro, Gene Neytman, Raymond Easley, Mariam Aziz, Joan Swiatek, Avish Nagpal, Breanna Kompelien, Kathryn McEvoy, Susan E. Hoover, Allison Lutz, Jessica Just, Manuel Hernandez, Yanly B. Victoria, Gabriel Rodriguez, Divya Pathak, Joshua J. Ordway, Megan Heffner, Patrick Weston, Khalilah Weston, Madhu Choudhary, Jennifer Sullivano, Olayemi Osiyemi, Myriam Izquierdo, Odelsey Torna, Brian Clemency, Renoj Varughese, Joshua Lynch, Aleen Khodabakhshian, Samantha Fortier, Christopher Coyne, Alexandrea Cronin, Constance Benson, Steven Hendrickx, Rosemarie Ramirez, Anne Luetkemeyer, Suzanne Hendler, Dennis Dentoni-Lasofsky, Mobeen Rathore, Saniyyah Mahmoudi, Amna Riaz, Mario Castro, Leslie Spikes, Chase Hall, Jonathan Oakes, Amy James Loftis, Pablo Tebas, William Short, Michael P. Dube, Saahir Khan, Luis M. Mendez, Sarah McGuffin, Chris Jonsson, Mamta K. Jain, Smruthi Senthil, Kimberly Turner-Gray, Sanjay Mehta, Mary Lewinski, Masoud Azizad, Christopher Chow, Lisa Nakatani, Derrick Williamson, Hisham Atriss, Matthew Caloura, Midhun Malla, Hannah Hazard-Jenkins, Aimee Wilkin, Jamraus Fayssoux, Hannah Seagle, Rachel Presti, and Alem Haile
Subjects: COVID-19, Monoclonal antibodies, Outpatient treatment, Clinical trial, Post COVID conditions, Long COVID, Medicine (General), R5-920
Abstract: Summary: Background: It is unknown if early COVID-19 monoclonal antibody (mAb) therapy can reduce risk of Long COVID. The mAbs amubarvimab/romlusevimab were previously demonstrated to reduce risk of hospitalization/death by 79%. This study assessed the impact of amubarvimab/romlusevimab on late outcomes, including Long COVID. Methods: Non-hospitalized high-risk adults within 10 days of COVID-19 symptom onset enrolled in a randomized, double-blind, placebo-controlled phase 2/3 trial of amubarvimab/romlusevimab for COVID-19 treatment. Late symptoms, assessed using a participant-completed symptom diary, were a pre-specified exploratory endpoint. The primary outcome for this analysis was the composite of Long COVID by participant self-report (presence of COVID-19 symptoms as recorded in the diary at week 36) or hospitalization or death by week 36. Inverse probability weighting (IPW) was used to address incomplete outcome ascertainment, giving weighted risk ratios (wRR) comparing amubarvimab/romlusevimab to placebo. Findings: Participants received amubarvimab/romlusevimab (n = 390) or placebo (n = 390) between January and July 2021. Median age was 49 years, 52% were female, 18% Black/African American, 49% Hispanic/Latino, and 9% COVID-19-vaccinated at entry. At week 36, 103 (13%) had incomplete outcome ascertainment, and 66 (17%) on amubarvimab/romlusevimab and 92 (24%) on placebo met the primary outcome (wRR = 0.70, 95% confidence interval (CI) 0.53–0.93). The difference was driven by fewer hospitalizations/deaths with amubarvimab/romlusevimab (4%) than placebo (13%). Among 652 participants with available diary responses, 53 (16%) on amubarvimab/romlusevimab and 44 (14%) on placebo reported presence of Long COVID. Interpretation: Amubarvimab/romlusevimab treatment, while highly effective in preventing hospitalizations/deaths, did not reduce risk of Long COVID. Additional interventions are needed to prevent Long COVID. Funding: National Institute of Allergy and Infectious Diseases of the National Institutes of Health. Amubarvimab and romlusevimab supplied by Brii Biosciences.
Published: 2024
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11. Breast cancer-related arm lymphoedema: a critical unmet need

Author: Sandra C. Hayes, Michael Bernas, Melanie L. Plinsinga, Christopher Pyke, Christobel Saunders, Neil Piller, Christine Moffatt, Vaughan Keeley, Natalie Kruger, Hildegard Reul-Hirche, and Alexandra L. McCarthy
Subjects: Medicine (General), R5-920
Published: 2024
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12. Search for heavy Majorana neutrinos in e±e± and e±μ± final states via WW scattering in pp collisions at s=13 TeV with the ATLAS detector

Author: G. Aad, E. Aakvaag, B. Abbott, S. Abdelhameed, K. Abeling, N.J. Abicht, S.H. Abidi, M. Aboelela, A. Aboulhorma, H. Abramowicz, H. Abreu, Y. Abulaiti, B.S. Acharya, A. Ackermann, C. Adam Bourdarios, L. Adamczyk, S.V. Addepalli, M.J. Addison, J. Adelman, A. Adiguzel, T. Adye, A.A. Affolder, Y. Afik, M.N. Agaras, J. Agarwala, A. Aggarwal, C. Agheorghiesei, A. Ahmad, F. Ahmadov, W.S. Ahmed, S. Ahuja, X. Ai, G. Aielli, A. Aikot, M. Ait Tamlihat, B. Aitbenchikh, M. Akbiyik, T.P.A. Åkesson, A.V. Akimov, D. Akiyama, N.N. Akolkar, S. Aktas, K. Al Khoury, G.L. Alberghi, J. Albert, P. Albicocco, G.L. Albouy, S. Alderweireldt, Z.L. Alegria, M. Aleksa, I.N. Aleksandrov, C. Alexa, T. Alexopoulos, F. Alfonsi, M. Algren, M. Alhroob, B. Ali, H.M.J. Ali, S. Ali, S.W. Alibocus, M. Aliev, G. Alimonti, W. Alkakhi, C. Allaire, B.M.M. Allbrooke, J.F. Allen, C.A. Allendes Flores, P.P. Allport, A. Aloisio, F. Alonso, C. Alpigiani, Z.M.K. Alsolami, M. Alvarez Estevez, A. Alvarez Fernandez, M. Alves Cardoso, M.G. Alviggi, M. Aly, Y. Amaral Coutinho, A. Ambler, C. Amelung, M. Amerl, C.G. Ames, D. Amidei, K.J. Amirie, S.P. Amor Dos Santos, K.R. Amos, S. An, V. Ananiev, C. Anastopoulos, T. Andeen, J.K. Anders, A.C. Anderson, S.Y. Andrean, A. Andreazza, S. Angelidakis, A. Angerami, A.V. Anisenkov, A. Annovi, C. Antel, E. Antipov, M. Antonelli, F. Anulli, M. Aoki, T. Aoki, M.A. Aparo, L. Aperio Bella, C. Appelt, A. Apyan, S.J. Arbiol Val, C. Arcangeletti, A.T.H. Arce, E. Arena, J-F. Arguin, S. Argyropoulos, J.-H. Arling, O. Arnaez, H. Arnold, G. Artoni, H. Asada, K. Asai, S. Asai, N.A. Asbah, R.A. Ashby Pickering, K. Assamagan, R. Astalos, K.S.V. Astrand, S. Atashi, R.J. Atkin, M. Atkinson, H. Atmani, P.A. Atmasiddha, K. Augsten, S. Auricchio, A.D. Auriol, V.A. Austrup, G. Avolio, K. Axiotis, G. Azuelos, D. Babal, H. Bachacou, K. Bachas, A. Bachiu, F. Backman, A. Badea, T.M. Baer, P. Bagnaia, M. Bahmani, D. Bahner, K. Bai, J.T. Baines, L. Baines, O.K. Baker, E. Bakos, D. Bakshi Gupta, L.E. Balabram Filho, V. Balakrishnan, R. Balasubramanian, E.M. Baldin, P. Balek, E. Ballabene, F. Balli, L.M. Baltes, W.K. Balunas, J. Balz, I. Bamwidhi, E. Banas, M. Bandieramonte, A. Bandyopadhyay, S. Bansal, L. Barak, M. Barakat, E.L. Barberio, D. Barberis, M. Barbero, M.Z. Barel, K.N. Barends, T. Barillari, M-S. Barisits, T. Barklow, P. Baron, D.A. Baron Moreno, A. Baroncelli, G. Barone, A.J. Barr, J.D. Barr, F. Barreiro, J. Barreiro Guimarães da Costa, U. Barron, M.G. Barros Teixeira, S. Barsov, F. Bartels, R. Bartoldus, A.E. Barton, P. Bartos, A. Basan, M. Baselga, A. Bassalat, M.J. Basso, S. Bataju, R. Bate, R.L. Bates, S. Batlamous, B. Batool, M. Battaglia, D. Battulga, M. Bauce, M. Bauer, P. Bauer, L.T. Bazzano Hurrell, J.B. Beacham, T. Beau, J.Y. Beaucamp, P.H. Beauchemin, P. Bechtle, H.P. Beck, K. Becker, A.J. Beddall, V.A. Bednyakov, C.P. Bee, L.J. Beemster, T.A. Beermann, M. Begalli, M. Begel, A. Behera, J.K. Behr, J.F. Beirer, F. Beisiegel, M. Belfkir, G. Bella, L. Bellagamba, A. Bellerive, P. Bellos, K. Beloborodov, D. Benchekroun, F. Bendebba, Y. Benhammou, K.C. Benkendorfer, L. Beresford, M. Beretta, E. Bergeaas Kuutmann, N. Berger, B. Bergmann, J. Beringer, G. Bernardi, C. Bernius, F.U. Bernlochner, F. Bernon, A. Berrocal Guardia, T. Berry, P. Berta, A. Berthold, S. Bethke, A. Betti, A.J. Bevan, N.K. Bhalla, S. Bhatta, D.S. Bhattacharya, P. Bhattarai, K.D. Bhide, V.S. Bhopatkar, R.M. Bianchi, G. Bianco, O. Biebel, R. Bielski, M. Biglietti, C.S. Billingsley, M. Bindi, A. Bingul, C. Bini, A. Biondini, G.A. Bird, M. Birman, M. Biros, S. Biryukov, T. Bisanz, E. Bisceglie, J.P. Biswal, D. Biswas, I. Bloch, A. Blue, U. Blumenschein, J. Blumenthal, V.S. Bobrovnikov, M. Boehler, B. Boehm, D. Bogavac, A.G. Bogdanchikov, C. Bohm, V. Boisvert, P. Bokan, T. Bold, M. Bomben, M. Bona, M. Boonekamp, C.D. Booth, A.G. Borbély, I.S. Bordulev, H.M. Borecka-Bielska, G. Borissov, D. Bortoletto, D. Boscherini, M. Bosman, J.D. Bossio Sola, K. Bouaouda, N. Bouchhar, L. Boudet, J. Boudreau, E.V. Bouhova-Thacker, D. Boumediene, R. Bouquet, A. Boveia, J. Boyd, D. Boye, I.R. Boyko, L. Bozianu, J. Bracinik, N. Brahimi, G. Brandt, O. Brandt, F. Braren, B. Brau, J.E. Brau, R. Brener, L. Brenner, R. Brenner, S. Bressler, G. Brianti, D. Britton, D. Britzger, I. Brock, G. Brooijmans, E.M. Brooks, E. Brost, L.M. Brown, L.E. Bruce, T.L. Bruckler, P.A. Bruckman de Renstrom, B. Brüers, A. Bruni, G. Bruni, M. Bruschi, N. Bruscino, T. Buanes, Q. Buat, D. Buchin, A.G. Buckley, O. Bulekov, B.A. Bullard, S. Burdin, C.D. Burgard, A.M. Burger, B. Burghgrave, O. Burlayenko, J.T.P. Burr, J.C. Burzynski, E.L. Busch, V. Büscher, P.J. Bussey, J.M. Butler, C.M. Buttar, J.M. Butterworth, W. Buttinger, C.J. Buxo Vazquez, A.R. Buzykaev, S. Cabrera Urbán, L. Cadamuro, D. Caforio, H. Cai, Y. Cai, V.M.M. Cairo, O. Cakir, N. Calace, P. Calafiura, G. Calderini, P. Calfayan, G. Callea, L.P. Caloba, D. Calvet, S. Calvet, M. Calvetti, R. Camacho Toro, S. Camarda, D. Camarero Munoz, P. Camarri, M.T. Camerlingo, D. Cameron, C. Camincher, M. Campanelli, A. Camplani, V. Canale, A.C. Canbay, E. Canonero, J. Cantero, Y. Cao, F. Capocasa, M. Capua, A. Carbone, R. Cardarelli, J.C.J. Cardenas, G. Carducci, T. Carli, G. Carlino, J.I. Carlotto, B.T. Carlson, E.M. Carlson, J. Carmignani, L. Carminati, A. Carnelli, M. Carnesale, S. Caron, E. Carquin, S. Carrá, G. Carratta, A.M. Carroll, T.M. Carter, M.P. Casado, M. Caspar, F.L. Castillo, L. Castillo Garcia, V. Castillo Gimenez, N.F. Castro, A. Catinaccio, J.R. Catmore, T. Cavaliere, V. Cavaliere, N. Cavalli, L.J. Caviedes Betancourt, Y.C. Cekmecelioglu, E. Celebi, S. Cella, F. Celli, M.S. Centonze, V. Cepaitis, K. Cerny, A.S. Cerqueira, A. Cerri, L. Cerrito, F. Cerutti, B. Cervato, A. Cervelli, G. Cesarini, S.A. Cetin, D. Chakraborty, J. Chan, W.Y. Chan, J.D. Chapman, E. Chapon, B. Chargeishvili, D.G. Charlton, M. Chatterjee, C. Chauhan, Y. Che, S. Chekanov, S.V. Chekulaev, G.A. Chelkov, A. Chen, B. Chen, H. Chen, J. Chen, M. Chen, S. Chen, S.J. Chen, X. Chen, Y. Chen, C.L. Cheng, H.C. Cheng, S. Cheong, A. Cheplakov, E. Cheremushkina, E. Cherepanova, R. Cherkaoui El Moursli, E. Cheu, K. Cheung, L. Chevalier, V. Chiarella, G. Chiarelli, N. Chiedde, G. Chiodini, A.S. Chisholm, A. Chitan, M. Chitishvili, M.V. Chizhov, K. Choi, Y. Chou, E.Y.S. Chow, K.L. Chu, M.C. Chu, X. Chu, Z. Chubinidze, J. Chudoba, J.J. Chwastowski, D. Cieri, K.M. Ciesla, V. Cindro, A. Ciocio, F. Cirotto, Z.H. Citron, M. Citterio, D.A. Ciubotaru, A. Clark, P.J. Clark, N. Clarke Hall, C. Clarry, J.M. Clavijo Columbie, S.E. Clawson, C. Clement, J. Clercx, Y. Coadou, M. Cobal, A. Coccaro, R.F. Coelho Barrue, R. Coelho Lopes De Sa, S. Coelli, L.S. Colangeli, B. Cole, J. Collot, P. Conde Muiño, M.P. Connell, S.H. Connell, E.I. Conroy, F. Conventi, H.G. Cooke, A.M. Cooper-Sarkar, F.A. Corchia, A. Cordeiro Oudot Choi, L.D. Corpe, M. Corradi, F. Corriveau, A. Cortes-Gonzalez, M.J. Costa, F. Costanza, D. Costanzo, B.M. Cote, J. Couthures, G. Cowan, K. Cranmer, D. Cremonini, S. Crépé-Renaudin, F. Crescioli, M. Cristinziani, M. Cristoforetti, V. Croft, J.E. Crosby, G. Crosetti, A. Cueto, H. Cui, Z. Cui, W.R. Cunningham, F. Curcio, J.R. Curran, P. Czodrowski, M.M. Czurylo, M.J. Da Cunha Sargedas De Sousa, J.V. Da Fonseca Pinto, C. Da Via, W. Dabrowski, T. Dado, S. Dahbi, T. Dai, D. Dal Santo, C. Dallapiccola, M. Dam, G. D'amen, V. D'Amico, J. Damp, J.R. Dandoy, D. Dannheim, M. Danninger, V. Dao, G. Darbo, S.J. Das, F. Dattola, S. D'Auria, A. D'avanzo, C. David, T. Davidek, I. Dawson, H.A. Day-hall, K. De, R. De Asmundis, N. De Biase, S. De Castro, N. De Groot, P. de Jong, H. De la Torre, A. De Maria, A. De Salvo, U. De Sanctis, F. De Santis, A. De Santo, J.B. De Vivie De Regie, D.V. Dedovich, J. Degens, A.M. Deiana, F. Del Corso, J. Del Peso, F. Del Rio, L. Delagrange, F. Deliot, C.M. Delitzsch, M. Della Pietra, D. Della Volpe, A. Dell'Acqua, L. Dell'Asta, M. Delmastro, P.A. Delsart, S. 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Vavricka, T. Vazquez Schroeder, J. Veatch, V. Vecchio, M.J. Veen, I. Veliscek, L.M. Veloce, F. Veloso, S. Veneziano, A. Ventura, S. Ventura Gonzalez, A. Verbytskyi, M. Verducci, C. Vergis, M. Verissimo De Araujo, W. Verkerke, J.C. Vermeulen, C. Vernieri, M. Vessella, M.C. Vetterli, A. Vgenopoulos, N. Viaux Maira, T. Vickey, O.E. Vickey Boeriu, G.H.A. Viehhauser, L. Vigani, M. Villa, M. Villaplana Perez, E.M. Villhauer, E. Vilucchi, M.G. Vincter, A. Visibile, C. Vittori, I. Vivarelli, E. Voevodina, F. Vogel, J.C. Voigt, P. Vokac, Yu. Volkotrub, J. Von Ahnen, E. Von Toerne, B. Vormwald, V. Vorobel, K. Vorobev, M. Vos, K. Voss, M. Vozak, L. Vozdecky, N. Vranjes, M. Vranjes Milosavljevic, M. Vreeswijk, N.K. Vu, R. Vuillermet, O. Vujinovic, I. Vukotic, S. Wada, C. Wagner, J.M. Wagner, W. Wagner, S. Wahdan, H. Wahlberg, M. Wakida, J. Walder, R. Walker, W. Walkowiak, A. Wall, E.J. Wallin, T. Wamorkar, A.Z. Wang, C. Wang, H. Wang, J. Wang, P. Wang, R. Wang, S.M. Wang, S. Wang, T. Wang, W.T. Wang, W. Wang, X. Wang, Y. Wang, Z. Wang, A. Warburton, R.J. Ward, N. Warrack, S. Waterhouse, A.T. Watson, H. Watson, M.F. Watson, E. Watton, G. Watts, B.M. Waugh, J.M. Webb, C. Weber, H.A. Weber, M.S. Weber, S.M. Weber, C. Wei, Y. Wei, A.R. Weidberg, E.J. Weik, J. Weingarten, C. Weiser, C.J. Wells, T. Wenaus, B. Wendland, T. Wengler, N.S. Wenke, N. Wermes, M. Wessels, A.M. Wharton, A.S. White, A. White, M.J. White, D. Whiteson, L. Wickremasinghe, W. Wiedenmann, M. Wielers, C. Wiglesworth, D.J. Wilbern, H.G. Wilkens, J.J.H. Wilkinson, D.M. Williams, H.H. Williams, S. Williams, S. Willocq, B.J. Wilson, P.J. Windischhofer, F.I. Winkel, F. Winklmeier, B.T. Winter, J.K. Winter, M. Wittgen, M. Wobisch, T. Wojtkowski, Z. Wolffs, J. Wollrath, M.W. Wolter, H. Wolters, M.C. Wong, E.L. Woodward, S.D. Worm, B.K. Wosiek, K.W. Woźniak, S. Wozniewski, K. Wraight, C. Wu, M. Wu, S.L. Wu, X. Wu, Y. Wu, Z. Wu, J. Wuerzinger, T.R. Wyatt, B.M. Wynne, S. Xella, L. Xia, M. Xia, J. Xiang, M. Xie, S. Xin, A. Xiong, J. Xiong, D. Xu, H. Xu, L. Xu, R. Xu, T. Xu, Y. Xu, Z. Xu, B. Yabsley, S. Yacoob, Y. Yamaguchi, E. Yamashita, H. Yamauchi, T. Yamazaki, Y. Yamazaki, J. Yan, S. Yan, Z. Yan, H.J. Yang, H.T. Yang, S. Yang, T. Yang, X. Yang, Y. Yang, Z. Yang, W-M. Yao, H. Ye, J. Ye, S. Ye, X. Ye, Y. Yeh, I. Yeletskikh, B.K. Yeo, M.R. Yexley, T.P. Yildirim, P. Yin, K. Yorita, S. Younas, C.J.S. Young, C. Young, C. Yu, Y. Yu, J. Yuan, M. Yuan, R. Yuan, L. Yue, M. Zaazoua, B. Zabinski, E. Zaid, Z.K. Zak, T. Zakareishvili, N. Zakharchuk, S. Zambito, J.A. Zamora Saa, J. Zang, D. Zanzi, O. Zaplatilek, C. Zeitnitz, H. Zeng, J.C. Zeng, D.T. Zenger, Jr, O. Zenin, T. Ženiš, S. Zenz, S. Zerradi, D. Zerwas, M. Zhai, D.F. Zhang, J. Zhang, K. Zhang, L. Zhang, P. Zhang, R. Zhang, S. Zhang, T. Zhang, X. Zhang, Y. Zhang, Z. Zhang, H. Zhao, T. Zhao, Y. Zhao, Z. Zhao, A. Zhemchugov, J. Zheng, K. Zheng, X. Zheng, Z. Zheng, D. Zhong, B. Zhou, H. Zhou, N. Zhou, Y. Zhou, C.G. Zhu, J. Zhu, X. Zhu, Y. Zhu, X. Zhuang, K. Zhukov, N.I. Zimine, J. Zinsser, M. Ziolkowski, L. Živković, A. Zoccoli, K. Zoch, T.G. Zorbas, O. Zormpa, W. Zou, and L. Zwalinski
Subjects: Physics, QC1-999
Abstract: A search for heavy Majorana neutrinos in scattering of same-sign W boson pairs in proton–proton collisions at s=13 TeV at the LHC is reported. The dataset used corresponds to an integrated luminosity of 140 fb−1, collected with the ATLAS detector during 2015–2018. The search is performed in final states including a same-sign ee or eμ pair and at least two jets with large invariant mass and a large rapidity difference. No significant excess of events with respect to the Standard Model background predictions is observed. The results are interpreted in a benchmark scenario of the Phenomenological Type-I Seesaw model. New constraints are set on the values of the |VeN|2 and |VeNVμN⁎| parameters for heavy Majorana neutrino masses between 50 GeV and 20 TeV, where VℓN is the matrix element describing the mixing of the heavy Majorana neutrino mass eigenstate with the Standard Model neutrino of flavour ℓ=e,μ. The sensitivity to the Weinberg operator is investigated and constraints on the effective ee and eμ Majorana neutrino masses are reported. The statistical combination of the ee and eμ channels with the previously published μμ channel is performed.
Published: 2024
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13. Investigation of the degradation behaviour of poly-L-lactic acid braided stents under real-time and accelerated conditions

Author: Agnese Lucchetti, Flavia Caronna, Lison Rocher, Karl Joyce, Martin Fawdry, Olena Kudina, William Ronan, Thomas Gries, and Ted J. Vaughan
Subjects: Polymers and polymer manufacture, TP1080-1185
Abstract: Degradation tests are a key step in the development of a bioresorbable stent. The present study focused on the degradation of bioresorbable stents made from PLLA filaments, and examined the variation of the physical, thermal, and mechanical properties of the material and the devices under both real-time and accelerated degradation conditions. Results showed that the undegraded filaments were highly crystalline and composed by both α and α′ crystalline phases, induced by both the melt spinning and heat treatment processes. The latter was shown to have an important influence on the further formation of α crystalline phase and therefore crystalline structure perfectioning. Real-time degradation tests showed that the devices maintained structural stability for up to a year, meeting the required 6-month degradation period for vascular stents. Degradation was shown to primarily affect the crystalline regions, and to cause a gradual loss of material ductility before any mass loss or decrease in crystallinity. In turn, a constant decrease of molecular weight was observed, with stent failure occurring around day 389 due to a drop in molecular weight below 10,000 g/mol. Accelerated degradation tests mirrored real-time results until mass loss began. Subsequently a slower molecular weight decrease was observed, with an increase and subsequent decrease of material crystallinity. The consistency of the data obtained between real-time and accelerated degradation before mass loss confirmed the possibility to gain insights into real-time degradation through an accelerated protocol. However, attention must be paid to the initial molecular weight of the material, which has been shown to highly influence the acceleration rate. This study provides a wide range of experimental data both on the real-time and thermally accelerated degradation behaviour of PLLA braided stents that can be used as benchmark for further studies in the field.
Published: 2024
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14. Estimating pathogen spread using structured coalescent and birth–death models: A quantitative comparison

Author: Sophie Seidel, Tanja Stadler, and Timothy G. Vaughan
Subjects: Phylodynamics, Phylogenetics, Pathogen spread, Birth–death, Coalescent, Infectious and parasitic diseases, RC109-216
Abstract: Elucidating disease spread between subpopulations is crucial in guiding effective disease control efforts. Genomic epidemiology and phylodynamics have emerged as key principles to estimate such spread from pathogen phylogenies derived from molecular data. Two well-established structured phylodynamic methodologies – based on the coalescent and the birth–death model – are frequently employed to estimate viral spread between populations. Nonetheless, these methodologies operate under distinct assumptions whose impact on the accuracy of migration rate inference is yet to be thoroughly investigated.In this manuscript, we present a simulation study, contrasting the inferential outcomes of the structured coalescent model with constant population size and the multitype birth–death model with a constant rate. We explore this comparison across a range of migration rates in endemic diseases and epidemic outbreaks. The results of the epidemic outbreak analysis revealed that the birth–death model exhibits a superior ability to retrieve accurate migration rates compared to the coalescent model, regardless of the actual migration rate. Thus, to estimate accurate migration rates, the population dynamics have to be accounted for. On the other hand, for the endemic disease scenario, our investigation demonstrates that both models produce comparable coverage and accuracy of the migration rates, with the coalescent model generating more precise estimates. Regardless of the specific scenario, both models similarly estimated the source location of the disease.This research offers tangible modelling advice for infectious disease analysts, suggesting the use of either model for endemic diseases. For epidemic outbreaks, or scenarios with varying population size, structured phylodynamic models relying on the Kingman coalescent with constant population size should be avoided as they can lead to inaccurate estimates of the migration rate. Instead, coalescent models accounting for varying population size or birth–death models should be favoured. Importantly, our study emphasises the value of directly capturing exponential growth dynamics which could be a useful enhancement for structured coalescent models.
Published: 2024
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15. Variables that impact HPV test accuracy during vaginal self collection workflow for cervical cancer screening

Author: Laurence Vaughan, Devin Gary, Millie Shah, Lyndsay Lewellen, Laura Galbraith, and Valentin Parvu
Subjects: HPV self collection, Uterine cervical neoplasms, Specimen handling, Analytic sample preparation methods, Human papillomavirus viruses, Clinical laboratory techniques, Gynecology and obstetrics, RG1-991, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract: Vaginal self collection (SC) is safe and effective for human papillomavirus (HPV) testing and can increase cervical cancer screening coverage for underserved women. To better understand the impact of SC methodology on HPV test outcomes, empirical testing was conducted using different swab collection workflows. Deposition of the collection swab into resuspension buffer resulted in a 2.4-cycle reduction in threshold detection of human beta-hemoglobin during PCR when compared to “swirl-and-toss”. In addition, reducing the swab resuspension volume from 10 mL to 3 mL resulted in a 2.6-cycle reduction in threshold detection of human beta-globin. A systematic literature search (01/01/2020 to 08/02/2023) of Ovid Medline and Embase, followed by data extraction and analysis, was conducted to further assess the impact of resuspension volume on performance following SC. HPV test performance for SC, relative to clinician collection (CC), was calculated for detection of cervical pre-cancer. Data were stratified by the resuspension volume ratio of SC to CC being either ≥ 1.0 or
Published: 2024
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16. Applying a modified streamlined disease risk analysis framework to a platypus conservation translocation, with special consideration for the conservation of ecto- and endoparasites

Author: Jessica Whinfield, Kristin Warren, Larry Vogelnest, and Rebecca Vaughan-Higgins
Subjects: Platypus, Wildlife health, Conservation translocation, Parasite conservation, Disease risk analysis, Zoology, QL1-991
Abstract: Platypuses are the world's most evolutionarily distinct mammal and have several host-specific ecto- and endoparasites. With platypus populations declining, consideration should also be given to preserving these high conservation priority parasites alongside their charismatic host. A disease risk analysis (DRA) was performed for a platypus conservation translocation, using a modified streamlined methodology that incorporated a parasite conservation framework. DRA frameworks rarely consider parasite conservation. Rather, parasites are typically considered myopically in terms of the potential harm they may cause their host. To address this, a previously proposed parasite conservation framework was incorporated into an existing streamlined DRA methodology. Incorporation of the two frameworks was achieved readily, although there is opportunity for further refinement of this process. This DRA is significant as it is the first performed for any monotreme species, and implements the emerging approach of balancing the health and disease risk of the host with parasite conservation.
Published: 2024
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17. A critically co-endangered feather louse Forficuloecus pezopori n. sp. (Phthiraptera: Philopteridae) detected through conservation intervention for the western ground parrot Pezoporus flaviventris (Psittaculidae)

Author: Storm Blas Martin, Sarah Keatley, Alisa Wallace, Rebecca J. Vaughan-Higgins, and Amanda Ash
Subjects: Co-extinction, Psocodea, Ischnocera, Lice, Endemic, Translocation, Zoology, QL1-991
Abstract: Forficuloecus pezopori Martin, Keatley & Ash n. sp. from the western ground parrot Pezoporus flaviventris North, 1911 (Psittaculidae) is proposed based on combined evidence from morphology and COI mitochondrial DNA. Phylogenetically, the new species is closest to its two known congeners from Western Australia: F. josephi Price, Johnson & Palma, 2008 from Bourke's parrot Neopsephotus bourkii (Gould, 1841) and the scarlet-chested parrot Neophema splendida (Gould, 1841), and F. palmai Guimarães, 1985 from the Australian ringneck parrot Barnardius zonarius (Shaw, 1805). Morphologically it is distinguishable by abdominal chaetotaxy and characters of the male genitalia, and is most similar to F. josephi and F. greeni Guimarães, 1985; the latter has no representative sequence data. Forficuloecus pezopori is the eleventh species of its genus and the only metazoan parasite known from P. flaviventris, which is among Australia's most endangered vertebrates. The new louse is apparently restricted to P. flaviventris and is therefore co-endangered, facing at least the same likelihood of extinction as its host. We recommend ongoing translocation and field monitoring efforts for P. flaviventris include monitoring but not treatment for lice infestations in otherwise healthy individuals, and that the care management plan for captive P. flaviventris considers that F. pezopori is similarly imperilled.
Published: 2024
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18. Measurement of vector boson production cross sections and their ratios using pp collisions at s=13.6 TeV with the ATLAS detector

Author: G. Aad, E. Aakvaag, B. Abbott, S. Abdelhameed, K. Abeling, N.J. Abicht, S.H. Abidi, M. Aboelela, A. Aboulhorma, H. Abramowicz, H. Abreu, Y. Abulaiti, B.S. Acharya, A. Ackermann, C. Adam Bourdarios, L. Adamczyk, S.V. Addepalli, M.J. Addison, J. Adelman, A. Adiguzel, T. Adye, A.A. Affolder, Y. Afik, M.N. Agaras, J. Agarwala, A. Aggarwal, C. Agheorghiesei, A. Ahmad, F. Ahmadov, W.S. Ahmed, S. Ahuja, X. Ai, G. Aielli, A. Aikot, M. Ait Tamlihat, B. Aitbenchikh, M. Akbiyik, T.P.A. Åkesson, A.V. Akimov, D. Akiyama, N.N. Akolkar, S. Aktas, K. Al Khoury, G.L. Alberghi, J. Albert, P. Albicocco, G.L. Albouy, S. Alderweireldt, Z.L. Alegria, M. Aleksa, I.N. Aleksandrov, C. Alexa, T. Alexopoulos, F. Alfonsi, M. Algren, M. Alhroob, B. Ali, H.M.J. Ali, S. Ali, S.W. Alibocus, M. Aliev, G. Alimonti, W. Alkakhi, C. Allaire, B.M.M. Allbrooke, J.F. Allen, C.A. Allendes Flores, P.P. Allport, A. Aloisio, F. Alonso, C. Alpigiani, Z.M.K. Alsolami, M. Alvarez Estevez, A. Alvarez Fernandez, M. Alves Cardoso, M.G. Alviggi, M. Aly, Y. Amaral Coutinho, A. Ambler, C. Amelung, M. Amerl, C.G. Ames, D. Amidei, K.J. Amirie, S.P. Amor Dos Santos, K.R. Amos, S. An, V. Ananiev, C. Anastopoulos, T. Andeen, J.K. Anders, S.Y. Andrean, A. Andreazza, S. Angelidakis, A. Angerami, A.V. Anisenkov, A. Annovi, C. Antel, E. Antipov, M. Antonelli, F. Anulli, M. Aoki, T. Aoki, M.A. Aparo, L. Aperio Bella, C. Appelt, A. Apyan, S.J. Arbiol Val, C. Arcangeletti, A.T.H. Arce, E. Arena, J-F. Arguin, S. Argyropoulos, J.-H. Arling, O. Arnaez, H. Arnold, G. Artoni, H. Asada, K. Asai, S. Asai, N.A. Asbah, K. Assamagan, R. Astalos, K.S.V. Astrand, S. Atashi, R.J. Atkin, M. Atkinson, H. Atmani, P.A. Atmasiddha, K. Augsten, S. Auricchio, A.D. Auriol, V.A. Austrup, G. Avolio, K. Axiotis, G. Azuelos, D. Babal, H. Bachacou, K. Bachas, A. Bachiu, F. Backman, A. Badea, T.M. Baer, P. Bagnaia, M. Bahmani, D. Bahner, K. Bai, J.T. Baines, L. Baines, O.K. Baker, E. Bakos, D. Bakshi Gupta, V. Balakrishnan, R. Balasubramanian, E.M. Baldin, P. Balek, E. Ballabene, F. Balli, L.M. Baltes, W.K. Balunas, J. Balz, I. Bamwidhi, E. Banas, M. Bandieramonte, A. Bandyopadhyay, S. Bansal, L. Barak, M. Barakat, E.L. Barberio, D. Barberis, M. Barbero, M.Z. Barel, K.N. Barends, T. Barillari, M-S. Barisits, T. Barklow, P. Baron, D.A. Baron Moreno, A. Baroncelli, G. Barone, A.J. Barr, J.D. Barr, F. Barreiro, J. Barreiro Guimarães da Costa, U. Barron, M.G. Barros Teixeira, S. Barsov, F. Bartels, R. Bartoldus, A.E. Barton, P. Bartos, A. Basan, M. Baselga, A. Bassalat, M.J. Basso, R. Bate, R.L. Bates, S. Batlamous, B. Batool, M. Battaglia, D. Battulga, M. Bauce, M. Bauer, P. Bauer, L.T. Bazzano Hurrell, J.B. Beacham, T. Beau, J.Y. Beaucamp, P.H. Beauchemin, P. Bechtle, H.P. Beck, K. Becker, A.J. Beddall, V.A. Bednyakov, C.P. Bee, L.J. Beemster, T.A. Beermann, M. Begalli, M. Begel, A. Behera, J.K. Behr, J.F. Beirer, F. Beisiegel, M. Belfkir, G. Bella, L. Bellagamba, A. Bellerive, P. Bellos, K. Beloborodov, D. Benchekroun, F. Bendebba, Y. Benhammou, K.C. Benkendorfer, L. Beresford, M. Beretta, E. Bergeaas Kuutmann, N. Berger, B. Bergmann, J. Beringer, G. Bernardi, C. Bernius, F.U. Bernlochner, F. Bernon, A. Berrocal Guardia, T. Berry, P. Berta, A. Berthold, S. Bethke, A. Betti, A.J. Bevan, N.K. Bhalla, S. Bhatta, D.S. Bhattacharya, P. Bhattarai, K.D. Bhide, V.S. Bhopatkar, R.M. Bianchi, G. Bianco, O. Biebel, R. Bielski, M. Biglietti, C.S. Billingsley, M. Bindi, A. Bingul, C. Bini, A. Biondini, G.A. Bird, M. Birman, M. Biros, S. Biryukov, T. Bisanz, E. Bisceglie, J.P. Biswal, D. Biswas, I. Bloch, A. Blue, U. Blumenschein, J. Blumenthal, V.S. Bobrovnikov, M. Boehler, B. Boehm, D. Bogavac, A.G. Bogdanchikov, C. Bohm, V. Boisvert, P. Bokan, T. Bold, M. Bomben, M. Bona, M. Boonekamp, C.D. Booth, A.G. Borbély, I.S. Bordulev, H.M. Borecka-Bielska, G. Borissov, D. Bortoletto, D. Boscherini, M. Bosman, J.D. Bossio Sola, K. Bouaouda, N. Bouchhar, L. Boudet, J. Boudreau, E.V. Bouhova-Thacker, D. Boumediene, R. Bouquet, A. Boveia, J. Boyd, D. Boye, I.R. Boyko, L. Bozianu, J. Bracinik, N. Brahimi, G. Brandt, O. Brandt, F. Braren, B. Brau, J.E. Brau, R. Brener, L. Brenner, R. Brenner, S. Bressler, D. Britton, D. Britzger, I. Brock, G. Brooijmans, E. Brost, L.M. Brown, L.E. Bruce, T.L. Bruckler, P.A. Bruckman de Renstrom, B. Brüers, A. Bruni, G. Bruni, M. Bruschi, N. Bruscino, T. Buanes, Q. Buat, D. Buchin, A.G. Buckley, O. Bulekov, B.A. Bullard, S. Burdin, C.D. Burgard, A.M. Burger, B. Burghgrave, O. Burlayenko, J.T.P. Burr, J.C. Burzynski, E.L. Busch, V. Büscher, P.J. Bussey, J.M. Butler, C.M. Buttar, J.M. Butterworth, W. Buttinger, C.J. Buxo Vazquez, A.R. Buzykaev, S. Cabrera Urbán, L. Cadamuro, D. Caforio, H. Cai, Y. Cai, V.M.M. Cairo, O. Cakir, N. Calace, P. Calafiura, G. Calderini, P. Calfayan, G. Callea, L.P. Caloba, D. Calvet, S. Calvet, M. Calvetti, R. Camacho Toro, S. Camarda, D. Camarero Munoz, P. Camarri, M.T. Camerlingo, D. Cameron, C. Camincher, M. Campanelli, A. Camplani, V. Canale, A.C. Canbay, E. Canonero, J. Cantero, Y. Cao, F. Capocasa, M. Capua, A. Carbone, R. Cardarelli, J.C.J. Cardenas, G. Carducci, T. Carli, G. Carlino, J.I. Carlotto, B.T. Carlson, E.M. Carlson, J. Carmignani, L. Carminati, A. Carnelli, M. Carnesale, S. Caron, E. Carquin, S. Carrá, G. Carratta, A.M. Carroll, T.M. Carter, M.P. Casado, M. Caspar, F.L. Castillo, L. Castillo Garcia, V. Castillo Gimenez, N.F. Castro, A. Catinaccio, J.R. Catmore, T. Cavaliere, V. Cavaliere, N. Cavalli, Y.C. Cekmecelioglu, E. Celebi, S. Cella, F. Celli, M.S. Centonze, V. Cepaitis, K. Cerny, A.S. Cerqueira, A. Cerri, L. Cerrito, F. Cerutti, B. Cervato, A. Cervelli, G. Cesarini, S.A. Cetin, D. Chakraborty, J. Chan, W.Y. Chan, J.D. Chapman, E. Chapon, B. Chargeishvili, D.G. Charlton, M. Chatterjee, C. Chauhan, Y. Che, S. Chekanov, S.V. Chekulaev, G.A. Chelkov, A. Chen, B. Chen, H. Chen, J. Chen, M. Chen, S. Chen, S.J. Chen, X. Chen, Y. Chen, C.L. Cheng, H.C. Cheng, S. Cheong, A. Cheplakov, E. 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Crosetti, A. Cueto, Z. Cui, W.R. Cunningham, F. Curcio, J.R. Curran, P. Czodrowski, M.M. Czurylo, M.J. Da Cunha Sargedas De Sousa, J.V. Da Fonseca Pinto, C. Da Via, W. Dabrowski, T. Dado, S. Dahbi, T. Dai, D. Dal Santo, C. Dallapiccola, M. Dam, G. D'amen, V. D'Amico, J. Damp, J.R. Dandoy, D. Dannheim, M. Danninger, V. Dao, G. Darbo, S.J. Das, F. Dattola, S. D'Auria, A. D'avanzo, C. David, T. Davidek, I. Dawson, H.A. Day-hall, K. De, R. De Asmundis, N. De Biase, S. De Castro, N. De Groot, P. de Jong, H. De la Torre, A. De Maria, A. De Salvo, U. De Sanctis, F. De Santis, A. De Santo, J.B. De Vivie De Regie, D.V. Dedovich, J. Degens, A.M. Deiana, F. Del Corso, J. Del Peso, F. Del Rio, L. Delagrange, F. Deliot, C.M. Delitzsch, M. Della Pietra, D. Della Volpe, A. Dell'Acqua, L. Dell'Asta, M. Delmastro, P.A. Delsart, S. Demers, M. Demichev, S.P. Denisov, L. D'Eramo, D. Derendarz, F. Derue, P. Dervan, K. Desch, C. Deutsch, F.A. Di Bello, A. Di Ciaccio, L. Di Ciaccio, A. Di Domenico, C. 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Quetant, R.P. Quinn, G. Rabanal Bolanos, D. Rafanoharana, F. Raffaeli, F. Ragusa, J.L. Rainbolt, J.A. Raine, S. Rajagopalan, E. Ramakoti, I.A. Ramirez-Berend, K. Ran, N.P. Rapheeha, H. Rasheed, V. Raskina, D.F. Rassloff, A. Rastogi, S. Rave, S. Ravera, B. Ravina, I. Ravinovich, M. Raymond, A.L. Read, N.P. Readioff, D.M. Rebuzzi, G. Redlinger, A.S. Reed, K. Reeves, J.A. Reidelsturz, D. Reikher, A. Rej, C. Rembser, M. Renda, M.B. Rendel, F. Renner, A.G. Rennie, A.L. Rescia, S. Resconi, M. Ressegotti, S. Rettie, J.G. Reyes Rivera, E. Reynolds, O.L. Rezanova, P. Reznicek, H. Riani, N. Ribaric, E. Ricci, R. Richter, S. Richter, E. Richter-Was, M. Ridel, S. Ridouani, P. Rieck, P. Riedler, E.M. Riefel, J.O. Rieger, M. Rijssenbeek, M. Rimoldi, L. Rinaldi, P. Rincke, T.T. Rinn, M.P. Rinnagel, G. Ripellino, I. Riu, J.C. Rivera Vergara, F. Rizatdinova, E. Rizvi, B.R. Roberts, S.H. Robertson, D. Robinson, C.M. Robles Gajardo, M. Robles Manzano, A. Robson, A. Rocchi, C. Roda, S. Rodriguez Bosca, Y. Rodriguez Garcia, A. Rodriguez Rodriguez, A.M. Rodríguez Vera, S. Roe, J.T. Roemer, A.R. Roepe-Gier, J. Roggel, O. Røhne, R.A. Rojas, C.P.A. Roland, J. Roloff, A. Romaniouk, E. Romano, M. Romano, A.C. Romero Hernandez, N. Rompotis, L. Roos, S. Rosati, B.J. Rosser, E. Rossi, L.P. Rossi, L. Rossini, R. Rosten, M. Rotaru, B. Rottler, C. Rougier, D. Rousseau, D. Rousso, A. Roy, S. Roy-Garand, A. Rozanov, Z.M.A. Rozario, Y. Rozen, A. Rubio Jimenez, A.J. Ruby, V.H. Ruelas Rivera, T.A. Ruggeri, A. Ruggiero, A. Ruiz-Martinez, A. Rummler, Z. Rurikova, N.A. Rusakovich, H.L. Russell, G. Russo, J.P. Rutherfoord, S. Rutherford Colmenares, M. Rybar, E.B. Rye, A. Ryzhov, J.A. Sabater Iglesias, P. Sabatini, H.F-W. Sadrozinski, F. Safai Tehrani, B. Safarzadeh Samani, S. Saha, M. Sahinsoy, A. Saibel, M. Saimpert, M. Saito, T. Saito, A. Sala, D. Salamani, A. Salnikov, J. Salt, A. Salvador Salas, D. Salvatore, F. Salvatore, A. Salzburger, D. Sammel, E. Sampson, D. Sampsonidis, D. Sampsonidou, J. Sánchez, V. Sanchez Sebastian, H. Sandaker, C.O. Sander, J.A. Sandesara, M. Sandhoff, C. Sandoval, L. Sanfilippo, D.P.C. Sankey, T. Sano, A. Sansoni, L. Santi, C. Santoni, H. Santos, A. Santra, E. Sanzani, K.A. Saoucha, J.G. Saraiva, J. Sardain, O. Sasaki, K. Sato, C. Sauer, E. Sauvan, P. Savard, R. Sawada, C. Sawyer, L. Sawyer, C. Sbarra, A. Sbrizzi, T. Scanlon, J. Schaarschmidt, U. Schäfer, A.C. Schaffer, D. Schaile, R.D. Schamberger, C. Scharf, M.M. Schefer, V.A. Schegelsky, D. Scheirich, M. Schernau, C. Scheulen, C. Schiavi, M. Schioppa, B. Schlag, K.E. Schleicher, S. Schlenker, J. Schmeing, M.A. Schmidt, K. Schmieden, C. Schmitt, N. Schmitt, S. Schmitt, L. Schoeffel, A. Schoening, P.G. Scholer, E. Schopf, M. Schott, J. Schovancova, S. Schramm, T. Schroer, H-C. Schultz-Coulon, M. Schumacher, B.A. Schumm, Ph. Schune, A.J. Schuy, H.R. Schwartz, A. Schwartzman, T.A. Schwarz, Ph. Schwemling, R. Schwienhorst, A. Sciandra, G. Sciolla, F. Scuri, C.D. Sebastiani, K. Sedlaczek, S.C. Seidel, A. Seiden, B.D. Seidlitz, C. Seitz, J.M. Seixas, G. Sekhniaidze, L. Selem, N. Semprini-Cesari, D. Sengupta, V. Senthilkumar, L. Serin, M. Sessa, H. Severini, F. Sforza, A. Sfyrla, Q. Sha, E. Shabalina, A.H. Shah, R. Shaheen, J.D. Shahinian, D. Shaked Renous, L.Y. Shan, M. Shapiro, A. Sharma, A.S. Sharma, P. Sharma, P.B. Shatalov, K. Shaw, S.M. Shaw, Q. Shen, D.J. Sheppard, P. Sherwood, L. Shi, X. Shi, C.O. Shimmin, J.D. Shinner, I.P.J. Shipsey, S. Shirabe, M. Shiyakova, M.J. Shochet, J. Shojaii, D.R. Shope, B. Shrestha, S. Shrestha, M.J. Shroff, P. Sicho, A.M. Sickles, E. Sideras Haddad, A.C. Sidley, A. Sidoti, F. Siegert, Dj. Sijacki, F. Sili, J.M. Silva, I. Silva Ferreira, M.V. Silva Oliveira, S.B. Silverstein, S. Simion, R. Simoniello, E.L. Simpson, H. Simpson, L.R. Simpson, N.D. Simpson, S. Simsek, S. Sindhu, P. Sinervo, S. Singh, S. Sinha, M. Sioli, I. Siral, E. Sitnikova, J. Sjölin, A. Skaf, E. Skorda, P. Skubic, M. Slawinska, V. Smakhtin, B.H. 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Stevenson, G.A. Stewart, J.R. Stewart, M.C. Stockton, G. Stoicea, M. Stolarski, S. Stonjek, A. Straessner, J. Strandberg, S. Strandberg, M. Stratmann, M. Strauss, T. Strebler, P. Strizenec, R. Ströhmer, D.M. Strom, R. Stroynowski, A. Strubig, S.A. Stucci, B. Stugu, J. Stupak, N.A. Styles, D. Su, S. Su, W. Su, X. Su, D. Suchy, K. Sugizaki, V.V. Sulin, M.J. Sullivan, D.M.S. Sultan, L. Sultanaliyeva, S. Sultansoy, T. Sumida, S. Sun, O. Sunneborn Gudnadottir, N. Sur, M.R. Sutton, H. Suzuki, M. Svatos, M. Swiatlowski, T. Swirski, I. Sykora, M. Sykora, T. Sykora, D. Ta, K. Tackmann, A. Taffard, R. Tafirout, J.S. Tafoya Vargas, Y. Takubo, M. Talby, A.A. Talyshev, K.C. Tam, N.M. Tamir, A. Tanaka, J. Tanaka, R. Tanaka, M. Tanasini, Z. Tao, S. Tapia Araya, S. Tapprogge, A. Tarek Abouelfadl Mohamed, S. Tarem, K. Tariq, G. Tarna, G.F. Tartarelli, M.J. Tartarin, P. Tas, M. Tasevsky, E. Tassi, A.C. Tate, G. Tateno, Y. Tayalati, G.N. Taylor, W. Taylor, R. Teixeira De Lima, P. Teixeira-Dias, J.J. Teoh, K. Terashi, J. Terron, S. Terzo, M. Testa, R.J. Teuscher, A. Thaler, O. Theiner, N. Themistokleous, T. Theveneaux-Pelzer, O. Thielmann, D.W. Thomas, J.P. Thomas, E.A. Thompson, P.D. Thompson, E. Thomson, R.E. Thornberry, C. Tian, Y. Tian, V. Tikhomirov, Yu.A. Tikhonov, S. Timoshenko, D. Timoshyn, E.X.L. Ting, P. Tipton, A. Tishelman-Charny, S.H. Tlou, K. Todome, S. Todorova-Nova, S. Todt, L. Toffolin, M. Togawa, J. Tojo, S. Tokár, K. Tokushuku, O. Toldaiev, R. Tombs, M. Tomoto, L. Tompkins, K.W. Topolnicki, E. Torrence, H. Torres, E. Torró Pastor, M. Toscani, C. Tosciri, M. Tost, D.R. Tovey, I.S. Trandafir, T. Trefzger, A. Tricoli, I.M. Trigger, S. Trincaz-Duvoid, D.A. Trischuk, B. Trocmé, L. Truong, M. Trzebinski, A. Trzupek, F. Tsai, M. Tsai, A. Tsiamis, P.V. Tsiareshka, S. Tsigaridas, A. Tsirigotis, V. Tsiskaridze, E.G. Tskhadadze, M. Tsopoulou, Y. Tsujikawa, I.I. Tsukerman, V. Tsulaia, S. Tsuno, K. Tsuri, D. Tsybychev, Y. Tu, A. Tudorache, V. Tudorache, A.N. Tuna, S. Turchikhin, I. Turk Cakir, R. Turra, T. Turtuvshin, P.M. Tuts, S. Tzamarias, E. Tzovara, F. Ukegawa, P.A. Ulloa Poblete, E.N. Umaka, G. Unal, A. Undrus, G. Unel, J. Urban, P. Urrejola, G. Usai, R. Ushioda, M. Usman, Z. Uysal, V. Vacek, B. Vachon, T. Vafeiadis, A. Vaitkus, C. Valderanis, E. Valdes Santurio, M. Valente, S. Valentinetti, A. Valero, E. Valiente Moreno, A. Vallier, J.A. Valls Ferrer, D.R. Van Arneman, T.R. Van Daalen, A. Van Der Graaf, P. Van Gemmeren, M. Van Rijnbach, S. Van Stroud, I. Van Vulpen, P. Vana, M. Vanadia, W. Vandelli, E.R. Vandewall, D. Vannicola, L. Vannoli, R. Vari, E.W. Varnes, C. Varni, T. Varol, D. Varouchas, L. Varriale, K.E. Varvell, M.E. Vasile, L. Vaslin, G.A. Vasquez, A. Vasyukov, L.M. Vaughan, R. Vavricka, T. Vazquez Schroeder, J. Veatch, V. Vecchio, M.J. Veen, I. Veliscek, L.M. Veloce, F. Veloso, S. Veneziano, A. Ventura, S. Ventura Gonzalez, A. Verbytskyi, M. Verducci, C. Vergis, M. Verissimo De Araujo, W. Verkerke, J.C. Vermeulen, C. Vernieri, M. Vessella, M.C. Vetterli, A. Vgenopoulos, N. Viaux Maira, T. Vickey, O.E. Vickey Boeriu, G.H.A. Viehhauser, L. Vigani, M. Villa, M. Villaplana Perez, E.M. Villhauer, E. Vilucchi, M.G. Vincter, A. Visibile, C. Vittori, I. Vivarelli, E. Voevodina, F. Vogel, J.C. Voigt, P. Vokac, Yu. Volkotrub, J. Von Ahnen, E. Von Toerne, B. Vormwald, V. Vorobel, K. Vorobev, M. Vos, K. Voss, M. Vozak, L. Vozdecky, N. Vranjes, M. Vranjes Milosavljevic, M. Vreeswijk, N.K. Vu, R. Vuillermet, O. Vujinovic, I. Vukotic, S. Wada, C. Wagner, J.M. Wagner, W. Wagner, S. Wahdan, H. Wahlberg, M. Wakida, J. Walder, R. Walker, W. Walkowiak, A. Wall, E.J. Wallin, T. Wamorkar, A.Z. Wang, C. Wang, H. Wang, J. Wang, P. Wang, R. Wang, S.M. Wang, S. Wang, T. Wang, W.T. Wang, W. Wang, X. Wang, Y. Wang, Z. Wang, A. Warburton, R.J. Ward, N. Warrack, S. Waterhouse, A.T. Watson, H. Watson, M.F. Watson, E. Watton, G. Watts, B.M. Waugh, J.M. Webb, C. Weber, H.A. Weber, M.S. Weber, S.M. Weber, C. Wei, Y. Wei, A.R. Weidberg, E.J. Weik, J. Weingarten, C. Weiser, C.J. Wells, T. Wenaus, B. Wendland, T. Wengler, N.S. Wenke, N. Wermes, M. Wessels, A.M. Wharton, A.S. White, A. White, M.J. White, D. Whiteson, L. Wickremasinghe, W. Wiedenmann, M. Wielers, C. Wiglesworth, D.J. Wilbern, H.G. Wilkens, J.J.H. Wilkinson, D.M. Williams, H.H. Williams, S. Williams, S. Willocq, B.J. Wilson, P.J. Windischhofer, F.I. Winkel, F. Winklmeier, B.T. Winter, J.K. Winter, M. Wittgen, M. Wobisch, T. Wojtkowski, Z. Wolffs, J. Wollrath, M.W. Wolter, H. Wolters, M.C. Wong, E.L. Woodward, S.D. Worm, B.K. Wosiek, K.W. Woźniak, S. Wozniewski, K. Wraight, C. Wu, M. Wu, S.L. Wu, X. Wu, Y. Wu, Z. Wu, J. Wuerzinger, T.R. Wyatt, B.M. Wynne, S. Xella, L. Xia, M. Xia, J. Xiang, M. Xie, S. Xin, A. Xiong, J. Xiong, D. Xu, H. Xu, L. Xu, R. Xu, T. Xu, Y. Xu, Z. Xu, B. Yabsley, S. Yacoob, Y. Yamaguchi, E. Yamashita, H. Yamauchi, T. Yamazaki, Y. Yamazaki, J. Yan, S. Yan, Z. Yan, H.J. Yang, H.T. Yang, S. Yang, T. Yang, X. Yang, Y. Yang, Z. Yang, W-M. Yao, H. Ye, J. Ye, S. Ye, X. Ye, Y. Yeh, I. Yeletskikh, B.K. Yeo, M.R. Yexley, T.P. Yildirim, P. Yin, K. Yorita, S. Younas, C.J.S. Young, C. Young, C. Yu, Y. Yu, M. Yuan, R. Yuan, L. Yue, M. Zaazoua, B. Zabinski, E. Zaid, Z.K. Zak, T. Zakareishvili, N. Zakharchuk, S. Zambito, J.A. Zamora Saa, J. Zang, D. Zanzi, O. Zaplatilek, C. Zeitnitz, H. Zeng, J.C. Zeng, D.T. Zenger, Jr, O. Zenin, T. Ženiš, S. Zenz, S. Zerradi, D. Zerwas, M. Zhai, D.F. Zhang, J. Zhang, K. Zhang, L. Zhang, P. Zhang, R. Zhang, S. Zhang, T. Zhang, X. Zhang, Y. Zhang, Z. Zhang, H. Zhao, T. Zhao, Y. Zhao, Z. Zhao, A. Zhemchugov, J. Zheng, K. Zheng, X. Zheng, Z. Zheng, D. Zhong, B. Zhou, H. Zhou, N. Zhou, Y. Zhou, C.G. Zhu, J. Zhu, X. Zhu, Y. Zhu, X. Zhuang, K. Zhukov, N.I. Zimine, J. Zinsser, M. Ziolkowski, L. Živković, A. Zoccoli, K. Zoch, T.G. Zorbas, O. Zormpa, W. Zou, and L. Zwalinski
Subjects: Physics, QC1-999
Abstract: Fiducial and total W± and Z boson cross sections, their ratios and the ratio of top-antitop-quark pair and W-boson fiducial cross sections are measured in proton–proton collisions at a centre-of-mass energy of s=13.6TeV, corresponding to an integrated luminosity of 29 fb−1 of data collected in 2022 by the ATLAS experiment at the Large Hadron Collider. The measured fiducial cross-section values for W+→ℓ+ν, W−→ℓ−ν¯, and Z→ℓ+ℓ− (ℓ=e or μ) boson productions are 4250±150pb, 3310±120pb, and 744±20pb, respectively, where the uncertainty is the total uncertainty, including that arising from the luminosity of about 2.2%. The measurements are in agreement with Standard-Model predictions calculated at next-to-next-to-leading-order in αs, next-to-next-to-leading logarithmic accuracy and next-to-leading-order electroweak accuracy.
Published: 2024
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19. Navigated peel-away sheath assisted placement of fully pre-assembled Ommaya reservoir systems: Technical note

Author: Connor A. Wathen, Maria Punchak, Peter Madsen, Kerry Vaughan, Vivek Buch, and Paul J. Marcotte
Subjects: Ommaya, navigation, peel-away sheath, Surgery, RD1-811, Neurology. Diseases of the nervous system, RC346-429
Published: 2024
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20. Effects of small-scale outplanting fertilization on conifer seedling growth and fungal community establishment

Author: Andreas N. Schneider, David Castro, Mattias Holmlund, Torgny Näsholm, Vaughan Hurry, and Nathaniel R. Street
Subjects: Seedling establishment, Rotation forestry, Scots pine, Norway spruce, Ectomycorrhiza, Fertilization, Forestry, SD1-669.5, Plant ecology, QK900-989
Abstract: Forestry in Sweden largely relies on planting genetically improved seedlings after clear-cutting, and high survival and early growth of planted seedlings is vital for stand establishment, economic viability, and carbon sequestration. Norway spruce (Picea abies) and Scots pine (Pinus sylvestris) are the two most important tree species in Swedish forest stands and both are associated with a variety of ectomycorrhizal fungi. While seedlings are generally not fertilized at outplanting, previous results have shown that fertilization with arginine phosphate can increase root growth and seedling survival. However, it is not clear how this affects fungal community composition on the roots of growing seedlings. In a planting experiment sampled after one and two growing seasons, we found that planting position had the largest effects both on seedling performance and on fungal community composition and provide insight into the early stages of fungal community succession on planted Norway spruce and Scots pine seedlings. Fungal taxa present on seedlings before planting persisted on seedling roots, while some degree of novel colonization by site indigenous taxa was observed. Fertilization modified the relative abundance of some fungal taxa but did not lead to significant changes in overall community composition. In terms of seedling performance, ammonium nitrate led to increased mortality while arginine phosphate improved root growth.
Published: 2024
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21. Dynamic modulation of mouse thalamocortical visual activity by salient sounds

Author: Clément E. Lemercier, Patrik Krieger, and Denise Manahan-Vaughan
Subjects: Natural sciences, Biological sciences, Neuroscience, Systems neuroscience, Sensory neuroscience, Science
Abstract: Summary: Visual responses of the primary visual cortex (V1) are altered by sound. Sound-driven behavioral arousal suggests that, in addition to direct inputs from the primary auditory cortex (A1), multiple other sources may shape V1 responses to sound. Here, we show in anesthetized mice that sound (white noise, ≥70dB) drives a biphasic modulation of V1 visually driven gamma-band activity, comprising fast-transient inhibitory and slow, prolonged excitatory (A1-independent) arousal-driven components. An analogous yet quicker modulation of the visual response also occurred earlier in the visual pathway, at the level of the dorsolateral geniculate nucleus (dLGN), where sound transiently inhibited the early phasic visual response and subsequently induced a prolonged increase in tonic spiking activity and gamma rhythmicity. Our results demonstrate that sound-driven modulations of visual activity are not exclusive to V1 and suggest that thalamocortical inputs from the dLGN to V1 contribute to shaping V1 visual response to sound.
Published: 2024
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22. The prognostic utility of temporalis muscle thickness measured on magnetic resonance scans in patients with intra-axial malignant brain tumours: A systematic review and meta-analysis

Author: Olatomiwa Olukoya, Temidayo Osunronbi, Damilola A. Jesuyajolu, Blossom C. Uwaga, Ayomide Vaughan, Oluwabusayo Aluko, Temitayo O. Ayantayo, Jeremiah O.I. Daniel, Samuel O. David, Habiblah A. Jagunmolu, Alieu Kanu, Ayomide T. Kayode, Tobi N. Olajide, and Lewis Thorne
Subjects: Brain metastases, Glioblastoma (GBM), Primary CNS lymphoma, Prognosis, Sarcopenia, Temporalis muscle thickness (TMT), Surgery, RD1-811, Neurology. Diseases of the nervous system, RC346-429
Abstract: Introduction: Sarcopenia is associated with worsened outcomes in solid cancers. Temporalis muscle thickness (TMT) has emerged as a measure of sarcopenia. Hence, this study aims to evaluate the relationship between TMT and outcome measures in patients with malignant intra-axial neoplasms. Method: We searched Medline, Embase, Scopus and Cochrane databases for relevant studies. Event ratios with 95% confidence intervals (CI) were analysed using the RevMan 5.4 software. Where meta-analysis was impossible, vote counting was used to determine the effect of TMT on outcomes. The GRADE framework was used to determine the certainty of the evidence. Results: Four outcomes were reported for three conditions across 17 studies involving 4430 patients. Glioblastoma: thicker TMT was protective for overall survival (OS) (HR 0.59; 95% CI 0.46–0.76) (GRADE low), progression free survival (PFS) (HR 0.40; 95% CI 0.26–0.62) (GRADE high), and early discontinuation of treatment (OR 0.408; 95% CI 0.168–0.989) (GRADE high); no association with complications (HR 0.82; 95% CI 0.60–1.10) (GRADE low). Brain Metastases: thicker TMT was protective for OS (HR 0.73; 95% CI 0.67–0.78) (GRADE moderate); no association with PFS (GRADE low). Primary CNS Lymphoma: TMT was protective for overall survival (HR 0.34; 95% CI 0.19–0.60) (GRADE moderate) and progression free survival (HR 0.23; 95% CI 0.09–0.56) (GRADE high). Conclusion: TMT has significant prognostic potential in intra-axial malignant neoplasms, showing a moderate to high certainty for its association with outcomes following GRADE evaluation. This will enable shared decision making between patients and clinicians.
Published: 2024
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23. Feasibility of a Self-directed Upper Extremity Training Program to Promote Actual Arm Use for Individuals Living in the Community With Chronic Stroke

Author: Grace J. Kim, PhD, Amanda Gahlot, MS, Camile Magsombol, OTD, Margaret Waskiewicz, OTD, Nettie Capasso, MS, Stephen Van Lew, PhD, Hayejin Kim, MS, Avinash Parnandi, PhD, Victoria Vaughan Dickson, PhD, and Yael Goverover, PhD
Subjects: Self-directed training, Actual arm use, Shared decision-making, Stroke, Upper extremity, Medicine (General), R5-920
Abstract: Objective: To determine the feasibility of a self-directed training protocol to promote actual arm use in everyday life. The secondary aim was to explore the initial efficacy on upper extremity (UE) outcome measures. Design: Feasibility study using multiple methods. Setting: Home and outpatient research lab. Participants: Fifteen adults (6 women, 9 men, mean age=53.08 years) with chronic stroke living in the community. There was wide range of UE functional levels, ranging from dependent stabilizer (limited function) to functional assist (high function). Intervention: Use My Arm-Remote protocol. Phase 1 consisted of clinician training on motivational interviewing (MI). Phase 2 consisted of MI sessions with participants to determine participant generated goals, training activities, and training schedules. Phase 3 consisted of UE task-oriented training (60 minutes/day, 5 days/week, for 4 weeks). Participants received daily surveys through an app to monitor arm training behavior and weekly virtual check-ins with clinicians to problem-solve challenges and adjust treatment plans. Outcome Measures: Primary outcome measures were feasibility domains after intervention, measured by quantitative study data and qualitative semi-structured interviews. Secondary outcomes included the Canadian Occupational Performance Measure (COPM), Motor Activity Log (MAL), Fugl-Meyer Assessment (FMA), and accelerometry-based duration of use metric measured at baseline, discharge, and 4-week follow-up. Results: The UMA-R was feasible in the following domains: recruitment rate, retention rate, intervention acceptance, intervention delivery, adherence frequency, and safety. Adherence to duration of daily practice did not meet our criteria. Improvements in UE outcomes were achieved at discharge and maintained at follow-up as measured by COPM-Performance subscale (F[1.42, 19.83]=17.72, P
Published: 2024
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24. Strategies for a scalable multi-robot large scale wire arc additive manufacturing system

Author: Alex Arbogast, Andrzej Nycz, Mark W. Noakes, Peter Wang, Christopher Masuo, Joshua Vaughan, Lonnie Love, Randall Lind, William Carter, Luke Meyer, Derek Vaughan, Alex Walters, Steven Patrick, Jonathan Paul, and Jason Flamm
Subjects: Additive manufacturing, Robotics, Machine intelligence, Directed energy deposition, Coordinated robot motion, 3D printing, Industrial engineering. Management engineering, T55.4-60.8
Abstract: Conventional robotic wire arc additive manufacturing technologies enable the rapid production of moderate-sized components using low-cost wire feedstocks and robotic welding systems. Efforts to date have primarily focused on single robot solutions. However, new configurations are possible with coordination of multiple robots and multi-degree of freedom positioners. This paper describes a new multi-agent control paradigm that enables multiple robots to work collaboratively on manufacturing a single component on a rotating platform. The advantages of this approach are increased deposition rate and productivity. This paper demonstrates this control strategy on a 19 degrees-of-freedom platform based on three wire arc additive systems surrounding a single rotating platform.
Published: 2024
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25. Prediction and understanding of non-linear distortion on large curved wall manufactured by wire-arc direct energy deposition

Author: Yousub Lee, Andrzej Nycz, Srdjan Simunovic, Luke Meyer, Derek Vaughan, William Carter, Sudarsanam S. Babu, Joshua Vaughan, and Lonnie Love
Subjects: Wire-arc direct energy deposition, Finite element method, Distortion mechanism, Additive manufacturing, Maintenance pauses, Industrial engineering. Management engineering, T55.4-60.8
Abstract: Wire-arc direct energy deposition (wire-arc DED) has been developed to manufacture large-scale metal products with high deposition rates, low material cost, and high material efficiency. However, dynamically varying printing conditions and complex geometries frequently lead to unfavorable part distortions during and after printing which are magnified as part sizes increase. In this study, an effective computational simulation method was developed for large-scale 316 L stainless steel parts using finite element method. The model was validated with the measured distortion using a 3D laser scanner. The distribution of deviation is within 16 % (=1.6 mm) against a measured value for a 483.6 mm tall part with 248 layers, with excellent agreement with the spatial pattern of distortion. The dynamic part deformation during printing and cooling was tracked using vision camera to investigate the thermo-mechanical deformation mechanism. The result showed that long pauses during machine maintenance pauses have strong influence on part distortion.
Published: 2023
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26. Tracking updates in clinical databases increases efficiency for variant reanalysis

Author: Lele Li, Xia Tian, Vaughan Woodzell, Richard A. Gibbs, Bo Yuan, and Eric Venner
Subjects: ACMG guideline, ClinVar, Efficiency, Reanalysis, Screening, Genetics, QH426-470, Medicine
Abstract: Purpose: Variant interpretation, guided by American College of Medical Genetics and Genomics guidelines, can inform clinical decision-making. However, interpretations may change over time for a variety of reasons. Periodic reanalysis of previous variant interpretations is important to ensure that reported genetic findings remain accurate according to current knowledge. Methods: We performed automated filtering by comparing ClinVar variants available in August 2020 with those from August 2021 to screen for potential reanalysis candidates from 3 projects. These variants were subsequently interpreted based on the American College of Medical Genetics and Genomics/Association for Molecular Pathology variant interpretation guideline or ClinGen revised gene-specific guidelines if applicable. Results: Our method annotated 241 unique variants requiring reanalysis, from 3 projects containing 3,832,210 previously interpreted variants, including those filtered automatically. Among these 241 variants, 43 variants changed interpretation, including 55.81% (N = 24) with upgraded and 44.19% (N = 19) with downgraded classifications. An efficiency study showed that our strategy increased the reanalysis efficiency and saved reviewing time. Conclusion: We demonstrated an effective high-throughput method, initiating from external data updates, to achieve variant reanalysis in a clinical laboratory. This filtering method reduced the number of variants that need to be reanalyzed, screened potential variants, and saved time and cost for clinical laboratories.
Published: 2024
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27. Laser induced graphene (LIG) biosensors derived from chitosan: Towards sustainable and green electronics

Author: Hassan Hamidi, Juliette Levieux, Cathal Larrigy, Alida Russo, Eoghan Vaughan, Richard Murray, Aidan J. Quinn, and Daniela Iacopino
Subjects: Green electronics, Direct laser writing, Glucose, Abundant materials, Biopolymers, Biotechnology, TP248.13-248.65
Abstract: Modern biosensors can provide real-time monitoring of individuals' health status, revolutionizing traditional healthcare diagnostics. As demand for these devices is continuously growing, the development of novel green materials and processes is mandatory to ensure sustainability. In this work, a simple laser direct writing approach was utilized to fabricate a novel green Laser Induced Graphene (LIG) glucose biosensor, whereby chitosan-based biofilms were used as writing feedstock material. Careful optimization of the biofilm composition was carried out in conjunction with the optimization of laser irradiation parameters to obtain bio-LIG structures with low sheet resistance and spectral characteristics of graphene-like materials. The surface of bio-LIG electrodes was modified with Prussian Blue nanoparticles and the electrocatalytic performance of bio-LIG sensors towards H2O2 was investigated using voltammetric techniques. The response of H2O2 was linear in the range 3 μM - 1 mM (sensitivity, 103.4 μA mM−1 cm−2 and the limit of detection (LOD), 1.9 μM). Following immobilization of glucose oxidase, the bio-LIG sensors showed a linear response of glucose in phosphate buffer (PBS) in the relevant physiological range of 25–300 μM (sensitivity, 457 nA mM−1 cm−2). The LOD was calculated as 9.6 μM. Additionally, the biosensor showed comparable results in artificial sweat.
Published: 2023
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28. Family physicians’ perspectives on collaboration challenges between primary care and specialist care during the COVID-19 pandemic in Canada: A qualitative study

Author: Lauren R. Moritz, Richard Buote, Madeleine McKay, Leslie Meredith, Dana Ryan, Sarah Spencer, Crystal Vaughan, Lindsay Hedden, Julia Lukewich, Maria Mathews, Shabnam Asghari, Judith Belle Brown, Paul S. Gill, Eric Wong, and Emily Gard Marshall
Subjects: Physicians, Primary care, COVID-19, Referral, Consultation, Collaboration, Public aspects of medicine, RA1-1270
Abstract: Background: Prior to the COVID-19 pandemic, Canada had longer wait-times for specialist appointments compared to other Commonwealth countries. During the pandemic, many specialist services were postponed or suspended, impacting access. The purpose of this study was to explore family physicians’ perspectives on specialist care availability during the pandemic and implications for family physician workload and patient management. These experiences can inform future pandemic plans. Methods: Using semi-structured interviews, we explored family physicians’ experiences during COVID-19 across regions within four Canadian provinces (British Columbia, Ontario, Nova Scotia, Newfoundland and Labrador). Thematic and framework analyses were used to identify themes from the interviews. Results: We interviewed 68 family physicians between October 2020 and June 2021. Of these 68 participants, 27 discussed their interactions with specialists during the pandemic. We identified themes around access to, and collaboration with, specialists. At times, specialists were less available for patient care and family physician consultations, and communications were uncoordinated across the system. Family physicians took on additional work to address the lack of access and identified pandemic planning challenges. Participants offered recommendations for improving collaboration and access post-pandemic. Interpretation: The COVID-19 pandemic exacerbated existing challenges in the Canadian healthcare system pertaining to specialist access. Pandemic plans should reflect the importance of specialist consultations. Decision-makers should consider innovations to facilitate collaboration between family physicians and specialists.
Published: 2023
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29. MAPPING THE NEURAL CIRCUITRY OF SIMPLE SOUND PERCEPTION IN AWAKE RATS: AN FMRI CONNECTOMIC STUDY

Author: Gabriele Russo and Denise Manahan-Vaughan
Subjects: Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Published: 2023
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30. ROLE OF PREFRONTAL CORTEX-VENTRAL-HIPPOCAMPUS NETWORK IN APPETITIVE SPATIAL EXTINCTION

Author: Marta Méndez-Couz and Denise Manahan-Vaughan
Subjects: Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Published: 2023
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31. RODENT GOAL-DIRECTED SKILLED ACTION IS MODULATED BY THE DOPAMINE RECEPTORS FOUND IN THE FASTIGIAL NUCLEUS

Author: Violeta Maria Caragea, Marta Mendez-Couz, and Denise Manahan-Vaughan
Subjects: Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Published: 2023
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32. PLACE CELLS MAP THE NEURAL SIGNATURES OF EXTINCTION LEARNING

Author: Laura Dolón Vera, Jose Donoso, Marta Mendez-Couz, Sen Cheng, and Denise Manahan-Vaughan
Subjects: Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Published: 2023
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33. ENHANCED SPATIAL MEMORY RENEWAL THROUGH Β-ADRENERGIC MODULATION OF BRAIN NETWORKS

Author: Josué Haubrich, Laura Dolon, and Denise Manahan-Vaughan
Subjects: Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Published: 2023
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34. Traumatic anterior shoulder dislocation with concomitant pectoralis rupture and Bankart lesion

Author: Alayna Vaughan, BA, Tyler Luthringer, MD, and Joseph Abboud, MD, MBA
Subjects: Anterior shoulder dislocation, Pectoralis major tendon rupture, Anterior inferior labral tear, Surgery, RD1-811
Published: 2023
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35. Integrative systems biology characterizes immune-mediated neurodevelopmental changes in murine Zika virus microcephaly

Author: Kimino Fujimura, Amanda J. Guise, Tojo Nakayama, Christoph N. Schlaffner, Anais Meziani, Mukesh Kumar, Long Cheng, Dylan J. Vaughan, Andrew Kodani, Simon Van Haren, Kenneth Parker, Ofer Levy, Ann F. Durbin, Irene Bosch, Lee Gehrke, Hanno Steen, Ganeshwaran H. Mochida, and Judith A. Steen
Subjects: Immunology, Virology, Developmental neuroscience, Science
Abstract: Summary: Characterizing perturbation of molecular pathways in congenital Zika virus (ZIKV) infection is critical for improved therapeutic approaches. Leveraging integrative systems biology, proteomics, and RNA-seq, we analyzed embryonic brain tissues from an immunocompetent, wild-type congenital ZIKV infection mouse model. ZIKV induced a robust immune response accompanied by the downregulation of critical neurodevelopmental gene programs. We identified a negative correlation between ZIKV polyprotein abundance and host cell cycle-inducing proteins. We further captured the downregulation of genes/proteins, many of which are known to be causative for human microcephaly, including Eomesodermin/T-box Brain Protein 2 (EOMES/TBR2) and Neuronal Differentiation 2 (NEUROD2). Disturbances of distinct molecular pathways in neural progenitors and post-mitotic neurons may contribute to complex brain phenotype of congenital ZIKV infection. Overall, this report on protein- and transcript-level dynamics enhances understanding of the ZIKV immunopathological landscape through characterization of fetal immune response in the developing brain.
Published: 2023
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36. A universal AutoScore framework to develop interpretable scoring systems for predicting common types of clinical outcomes

Author: Feng Xie, Yilin Ning, Mingxuan Liu, Siqi Li, Seyed Ehsan Saffari, Han Yuan, Victor Volovici, Daniel Shu Wei Ting, Benjamin Alan Goldstein, Marcus Eng Hock Ong, Roger Vaughan, Bibhas Chakraborty, and Nan Liu
Subjects: Health Sciences, Computer sciences, Science (General), Q1-390
Abstract: Summary: The AutoScore framework can automatically generate data-driven clinical scores in various clinical applications. Here, we present a protocol for developing clinical scoring systems for binary, survival, and ordinal outcomes using the open-source AutoScore package. We describe steps for package installation, detailed data processing and checking, and variable ranking. We then explain how to iterate through steps for variable selection, score generation, fine-tuning, and evaluation to generate understandable and explainable scoring systems using data-driven evidence and clinical knowledge.For complete details on the use and execution of this protocol, please refer to Xie et al. (2020),1 Xie et al. (2022)2, Saffari et al. (2022)3 and the online tutorial https://nliulab.github.io/AutoScore/. : Publisher’s note: Undertaking any experimental protocol requires adherence to local institutional guidelines for laboratory safety and ethics.
Published: 2023
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37. Body mapping as a participatory method to explore health provider beliefs and understanding about sexual and reproductive health and rights in Timor-Leste

Author: Helen Henderson, Alexandrina Marques da Silva, Mariano da Silva, Helio Afranio Soares Xavier, Silvina Amaral Mendonca, Rui Maria de Araújo, Cathy Vaughan, and Meghan A. Bohren
Subjects: Body mapping, Participatory research, Sexual and reproductive health, Male contraception, South-east Asia, Public aspects of medicine, RA1-1270
Abstract: Understanding the attitudes, knowledge, and practice of a health provider towards sexual and reproductive health (SRH) can provide valuable insight about how a primary health care system is functioning, and if it is meeting the SRH needs of its population. We conducted collaborative, participatory, and operational research to explore access to male methods of family planning in The Democratic Republic of Timor-Leste (Timor-Leste), from a health provider perspective. We conducted in-depth interviews (IDIs) with 24 health providers in 2019. Fifteen midwives, four doctors, three nurses and two family planning counsellors participated (16 women, 8 men; aged 25–56 years). IDIs comprised of semi-structured open-ended questions followed by body mapping activities. Moving from open-ended questions to body mapping activities enabled participants to engage with the research questions in complimentary but different ways, resulting in more in-depth and insightful data. The body mapping activities provided flexibility, time and scope for participants to reflect on their beliefs and practices in a more detailed and tangible way, and in ways they controlled and found acceptable. Data were analysed using reflexive thematic analysis. The body mapping method helped to demonstrate there was limited knowledge and experience about male SRH amongst health providers participating in our study, with many expressing interest to upskill in this area. Insights from our research can be used to inform health policy and programmatic decision-making in Timor-Leste. We conclude that when used appropriately, body mapping is an effective participatory research tool that can be used with health providers to explore SRH.
Published: 2023
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38. Using brain cell-type-specific protein interactomes to interpret neurodevelopmental genetic signals in schizophrenia

Author: Yu-Han H. Hsu, Greta Pintacuda, Ruize Liu, Eugeniu Nacu, April Kim, Kalliopi Tsafou, Natalie Petrossian, William Crotty, Jung Min Suh, Jackson Riseman, Jacqueline M. Martin, Julia C. Biagini, Daya Mena, Joshua K.T. Ching, Edyta Malolepsza, Taibo Li, Tarjinder Singh, Tian Ge, Shawn B. Egri, Benjamin Tanenbaum, Caroline R. Stanclift, Annie M. Apffel, Steven A. Carr, Monica Schenone, Jake Jaffe, Nadine Fornelos, Hailiang Huang, Kevin C. Eggan, Kasper Lage, Stephan Ripke, Benjamin M. Neale, Aiden Corvin, James T.R. Walters, Kai-How Farh, Peter A. Holmans, Phil Lee, Brendan Bulik-Sullivan, David A. Collier, Tune H. Pers, Ingrid Agartz, Esben Agerbo, Margot Albus, Madeline Alexander, Farooq Amin, Silviu A. Bacanu, Martin Begemann, Richard A. Belliveau, Jr., Judit Bene, Sarah E. Bergen, Elizabeth Bevilacqua, Tim B. Bigdeli, Donald W. Black, Richard Bruggeman, Nancy G. Buccola, Randy L. Buckner, William Byerley, Wiepke Cahn, Guiqing Cai, Dominique Campion, Rita M. Cantor, Vaughan J. Carr, Noa Carrera, Stanley V. Catts, Kimberley D. Chambert, Raymond C.K. Chan, Ronald Y.L. Chan, Eric Y.H. Chen, Wei Cheng, Eric FC. Cheung, Siow Ann Chong, C. Robert Cloninger, David Cohen, Nadine Cohen, Paul Cormican, Nick Craddock, James J. Crowley, David Curtis, Michael Davidson, Kenneth L. Davis, Franziska Degenhardt, Jurgen Del Favero, Ditte Demontis, Dimitris Dikeos, Timothy Dinan, Srdjan Djurovic, Gary Donohoe, Elodie Drapeau, Jubao Duan, Frank Dudbridge, Naser Durmishi, Peter Eichhammer, Johan Eriksson, Valentina Escott-Price, Laurent Essioux, Ayman H. Fanous, Martilias S. Farrell, Josef Frank, Lude Franke, Robert Freedman, Nelson B. Freimer, Marion Friedl, Joseph I. Friedman, Menachem Fromer, Giulio Genovese, Lyudmila Georgieva, Ina Giegling, Paola Giusti-Rodríguez, Stephanie Godard, Jacqueline I. Goldstein, Vera Golimbet, Srihari Gopal, Jacob Gratten, Lieuwe de Haan, Christian Hammer, Marian L. Hamshere, Mark Hansen, Thomas Hansen, Vahram Haroutunian, Annette M. Hartmann, Frans A. Henskens, Stefan Herms, Joel N. Hirschhorn, Per Hoffmann, Andrea Hofman, Mads V. Hollegaard, David M. Hougaard, Masashi Ikeda, Inge Joa, Antonio Julià, René S. Kahn, Luba Kalaydjieva, Sena Karachanak-Yankova, Juha Karjalainen, David Kavanagh, Matthew C. Keller, James L. Kennedy, Andrey Khrunin, Yunjung Kim, Janis Klovins, James A. Knowles, Bettina Konte, Vaidutis Kucinskas, Zita Ausrele Kucinskiene, Hana Kuzelova-Ptackova, Anna K. Kähler, Claudine Laurent, Jimmy Lee, S. Hong Lee, Sophie E. Legge, Bernard Lerer, Miaoxin Li, Tao Li, Kung-Yee Liang, Jeffrey Lieberman, Svetlana Limborska, Carmel M. Loughland, Jan Lubinski, Jouko Lönnqvist, Milan Macek, Patrik K.E. Magnusson, Brion S. Maher, Wolfgang Maier, Jacques Mallet, Sara Marsal, Manuel Mattheisen, Morten Mattingsdal, Robert W. McCarley, Colm McDonald, Andrew M. McIntosh, Sandra Meier, Carin J. Meijer, Bela Melegh, Ingrid Melle, Raquelle I. Mesholam-Gately, Andres Metspalu, Patricia T. Michie, Lili Milani, Vihra Milanova, Younes Mokrab, Derek W. Morris, Ole Mors, Kieran C. Murphy, Robin M. Murray, Inez Myin-Germeys, Bertram Müller-Myhsok, Mari Nelis, Igor Nenadic, Deborah A. Nertney, Gerald Nestadt, Kristin K. Nicodemus, Liene Nikitina-Zake, Laura Nisenbaum, Annelie Nordin, Eadbhard O'Callaghan, Colm O'Dushlaine, F. Anthony O'Neill, Sang-Yun Oh, Ann Olincy, Line Olsen, Jim Van Os, Christos Pantelis, George N. Papadimitriou, Sergi Papiol, Elena Parkhomenko, Michele T. Pato, Tiina Paunio, Milica Pejovic-Milovancevic, Diana O. Perkins, Olli Pietiläinen, Jonathan Pimm, Andrew J. Pocklington, John Powell, Alkes Price, Ann E. Pulver, Shaun M. Purcell, Digby Quested, Henrik B. Rasmussen, Abraham Reichenberg, Mark A. Reimers, Alexander L. Richards, Joshua L. Roffman, Panos Roussos, Douglas M. Ruderfer, Veikko Salomaa, Alan R. Sanders, Ulrich Schall, Christian R. Schubert, Thomas G. Schulze, Sibylle G. Schwab, Edward M. Scolnick, Rodney J. Scott, Larry J. Seidman, Jianxin Shi, Engilbert Sigurdsson, Teimuraz Silagadze, Jeremy M. Silverman, Kang Sim, Petr Slominsky, Jordan W. Smoller, Hon-Cheong So, Chris C.A. Spencer, Eli A. Stahl, Hreinn Stefansson, Stacy Steinberg, Elisabeth Stogmann, Richard E. Straub, Eric Strengman, Jana Strohmaier, T Scott Stroup, Mythily Subramaniam, Jaana Suvisaari, Dragan M. Svrakic, Jin P. Szatkiewicz, Erik Söderman, Srinivas Thirumalai, Draga Toncheva, Sarah Tosato, Juha Veijola, John Waddington, Dermot Walsh, Dai Wang, Qiang Wang, Bradley T. Webb, Mark Weiser, Dieter B. Wildenauer, Nigel M. Williams, Stephanie Williams, Stephanie H. Witt, Aaron R. Wolen, Emily H.M. Wong, Brandon K. Wormley, Hualin Simon Xi, Clement C. Zai, Xuebin Zheng, Fritz Zimprich, Naomi R. Wray, Kari Stefansson, Peter M. Visscher, Rolf Adolfsson, Ole A. Andreassen, Douglas H.R. Blackwood, Elvira Bramon, Joseph D. Buxbaum, Anders D. Børglum, Sven Cichon, Ariel Darvasi, Enrico Domenici, Hannelore Ehrenreich, Tõnu Esko, Pablo V. Gejman, Michael Gill, Hugh Gurling, Christina M. Hultman, Nakao Iwata, Assen V. Jablensky, Erik G. Jönsson, Kenneth S. Kendler, George Kirov, Jo Knight, Todd Lencz, Douglas F. Levinson, Qingqin S. Li, Jianjun Liu, Anil K. Malhotra, Steven A. McCarroll, Andrew McQuillin, Jennifer L. Moran, Preben B. Mortensen, Bryan J. Mowry, Markus M. Nöthen, Roel A. Ophoff, Michael J. Owen, Aarno Palotie, Carlos N. Pato, Tracey L. Petryshen, Danielle Posthuma, Marcella Rietschel, Brien P. Riley, Dan Rujescu, Pak C. Sham, Pamela Sklar, David St Clair, Daniel R. Weinberger, Jens R. Wendland, Thomas Werge, Mark J. Daly, Patrick F. Sullivan, Michael C. O'Donovan, Shengying Qin, Akira Sawa, Rene Kahn, Kyung Sue Hong, Wenzhao Shi, Ming Tsuang, Masanari Itokawa, Gang Feng, Stephen J. Glatt, Xiancang Ma, Jinsong Tang, Yunfeng Ruan, Feng Zhu, Yasue Horiuchi, Byung Dae Lee, Eun-Jeong Joo, Woojae Myung, Kyooseob Ha, Hong-Hee Won, Ji Hyung Baek, Young Chul Chung, Sung-Wan Kim, Agung Kusumawardhani, Wei J. Chen, Hai-Gwo Hwu, Akitoyo Hishimoto, Ikuo Otsuka, Ichiro Sora, Tomoko Toyota, Takeo Yoshikawa, Hiroshi Kunugi, Kotaro Hattori, Sayuri Ishiwata, Shusuke Numata, Tetsuro Ohmori, Makoto Arai, Yuji Ozeki, Kumiko Fujii, Se Joo Kim, Heon-Jeong Lee, Yong Min Ahn, Se Hyun Kim, Kazufumi Akiyama, Kazutaka Shimoda, and Makoto Kinoshita
Subjects: Molecular interaction, Developmental neuroscience, Cellular neuroscience, Proteomics, Science
Abstract: Summary: Genetics have nominated many schizophrenia risk genes and identified convergent signals between schizophrenia and neurodevelopmental disorders. However, functional interpretation of the nominated genes in the relevant brain cell types is often lacking. We executed interaction proteomics for six schizophrenia risk genes that have also been implicated in neurodevelopment in human induced cortical neurons. The resulting protein network is enriched for common variant risk of schizophrenia in Europeans and East Asians, is down-regulated in layer 5/6 cortical neurons of individuals affected by schizophrenia, and can complement fine-mapping and eQTL data to prioritize additional genes in GWAS loci. A sub-network centered on HCN1 is enriched for common variant risk and contains proteins (HCN4 and AKAP11) enriched for rare protein-truncating mutations in individuals with schizophrenia and bipolar disorder. Our findings showcase brain cell-type-specific interactomes as an organizing framework to facilitate interpretation of genetic and transcriptomic data in schizophrenia and its related disorders.
Published: 2023
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39. The COVID-19 laboratory response in Timor-Leste; a story of collaboration

Author: Nevio Sarmento, Endang Soares da Silva, Ismael Barreto, João C. Ximenes, Julia M. Angelina, Dircia M. Correia, Silvia M. Babo, Ari Jayanti P. Tilman, Antonio Salles de Sousa, Elisabeth Hornay, Lourenço C. Ico, Filipe de Neri Machado, Maria Varela Niha, Susan Ballard, Chantel Lin, Benjamin Howden, Rob Baird, Johanna Wapling, Lucsendar Alves, Tessa Oakley, Ian Marr, Anthony D.K. Draper, Paul Arkell, Heidi Smith-Vaughan, Nicholas S.S. Fancourt, Jennifer Yan, and Joshua R. Francis
Subjects: Timor-Leste, COVID-19, SARS-CoV-2, Laboratory response, Pandemic, Low-resource, Public aspects of medicine, RA1-1270
Abstract: Summary: Timor-Leste is a small nation of 1.3 million people which shares a land border with Indonesia and is 550 km from Darwin, Australia. It is one of the poorest nations in Asia. The National Health Laboratory (NHL) and its network of smaller laboratories in Timor-Leste had limited capacity to perform molecular diagnostic testing before the coronavirus disease 2019 (COVID-19) pandemic began.With the support of international development partners, the NHL rapidly expanded its molecular testing service. From March 2020 to February 2022, over 200,000 molecular tests were performed; COVID-19 testing sites were established in hospital and community health center laboratories and all 13 municipalities, and the number of scientists and technicians at the molecular diagnostic laboratory at the NHL increased from five to 28 between 2019 and 2022.Molecular diagnostic testing for COVID-19 was successfully established at the NHL and in the municipalities. The molecular diagnostic laboratory at NHL is now equipped to respond to not only large-scale COVID-19 testing but also laboratory detection of other infectious diseases, preparing Timor-Leste for future outbreaks or pandemics.
Published: 2023
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40. Effect of different schedules of ten-valent pneumococcal conjugate vaccine on pneumococcal carriage in Vietnamese infants: results from a randomised controlled trialResearch in context

Author: Heidi Smith-Vaughan, Beth Temple, Vo Thi Trang Dai, Pham Thi Hoan, Ho Nguyen Loc Thuy, Thanh V. Phan, Kathryn Bright, Nguyen Trong Toan, Doan Y. Uyen, Cattram Duong Nguyen, Jemima Beissbarth, Belinda Daniela Ortika, Monica Larissa Nation, Eileen Margaret Dunne, Jason Hinds, Jana Lai, Catherine Satzke, Tran Ngoc Huu, and Kim Mulholland
Subjects: Pneumococcal conjugate vaccine, Pneumococcal carriage, Vaccine schedules, Public aspects of medicine, RA1-1270
Abstract: Summary: Background: WHO recommends a three-dose infant pneumococcal conjugate vaccine (PCV) schedule administered as a two-dose primary series with booster (2 + 1) or a three-dose primary series (3 + 0). Data on carriage impacts of these and further reduced PCV schedules are needed to inform PCV strategies. Here we evaluate the efficacy against carriage of four different PCV10 schedules. Methods: Participants within an open-label, randomised controlled trial in Ho Chi Minh City, Vietnam, were allocated to receive PCV10 in a 3 + 1 (2,3,4,9 months, n = 152), 3 + 0 (2,3,4 months, n = 149), 2 + 1 (2,4,9.5 months, n = 250) or novel two-dose (2,6 months, n = 202) schedule, or no infant doses of PCV (two control groups, n = 197 and n = 199). Nasopharyngeal swabs collected between 2 and 24 months were analysed (blinded) for pneumococcal carriage and serotypes. Trial registration: ClinicalTrials.gov NCT01953510. Findings: Pneumococcal carriage prevalence was low (10.6–14.1% for vaccine-type (VT) at 12–24 months in unvaccinated controls). All four PCV10 schedules reduced VT carriage compared with controls (the 2 + 1 schedule at 12, 18, and 24 months; the 3 + 1 and two-dose schedules at 18 months; and the 3 + 0 schedule at 24 months), with maximum reductions of 40.1%–64.5%. There were no differences in VT carriage prevalence at 6 or 9 months comparing three-dose and two-dose primary series, and no differences at 12, 18, or 24 months when comparing schedules with and without a booster dose. Interpretation: In Vietnamese children with a relatively low pneumococcal carriage prevalence, 3 + 1, 2 + 1, 3 + 0 and two-dose PCV10 schedules were effective in reducing VT carriage. There were no discernible differences in the effect on carriage of the WHO-recommended 2 + 1 and 3 + 0 schedules during the first two years of life. Together with the previously reported immunogenicity data, this trial suggests that a range of PCV schedules are likely to generate significant direct and indirect protection. Funding: NHMRC, BMGF
Published: 2023
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41. The psychological impact of the coronavirus disease 2019 pandemic on women who become pregnant after receiving treatment for infertility: a longitudinal study

Author: Alice D. Domar, Ph.D., Jaimin S. Shah, M.D., Annika Gompers, Ph.D., Alison J. Meyers, B.A., Darya R. Khodakhah, Michele R. Hacker, Sc.D., Alan S. Penzias, M.D., Denny Sakkas, Ph.D., Thomas L. Toth, M.D., and Denis A. Vaughan, M.D.
Subjects: COVID-19, infertility, stressors, distress, pregnancy, Diseases of the genitourinary system. Urology, RC870-923, Gynecology and obstetrics, RG1-991
Abstract: Objective: To compare the impact of the coronavirus disease 2019 (COVID-19) pandemic on the psychological health of patients with infertility who have become pregnant with that of women who have not. Design: Prospective cohort study conducted from April 2020 to June 2020. The participants completed three questionnaires over this period. Setting: A single large, university-affiliated infertility practice. Patients: A total of 443 pregnant women and 1,476 women still experiencing infertility who completed all three questionnaires. Interventions: None. Main Outcome Measures: Patient-reported primary stressor over three months of the first major COVID-19 surge; further data on self-reported sadness, anxiety, loneliness, and the use of personal coping strategies. Results: Pregnant participants were significantly less likely to report taking an antidepressant or anxiolytic medication, were less likely to have a prior diagnosis of depression, were more likely to cite COVID-19 as a top stressor, and overall were less likely to practice stress-relieving activities during the first surge. Conclusions: Women who became pregnant after receiving treatment for infertility cited the pandemic as their top stressor and were more distressed about the pandemic than their nonpregnant counterparts but were less likely to be engaging in stress-relieving activities. Given the ongoing impact of the pandemic, patients with infertility who become pregnant after receiving treatment should be counseled and encouraged to practice specific stress-reduction strategies.
Published: 2022
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42. Timely Curative Treatment and Overall Mortality Among Veterans With Stage I NSCLC

Author: Rolando Sanchez, MD, MS, Mary S. Vaughan Sarrazin, PhD, and Richard M. Hoffman, MD, MPH
Subjects: Veterans, Early-stage lung cancer, Non–small cell lung cancer, Lung cancer screening, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract: Introduction: Early stage lung cancer (LC) outcomes depend on the receipt of timely therapy. We aimed to determine the proportions of Veterans with stage I NSCLC in the age group eligible for LC screening (LCS) receiving timely curative treatment (≤12 wk after diagnosis), the factors associated with timely treatment and modality, and the factors associated with overall mortality. Methods: Retrospective cohort study in Veterans aged 55 to 80 years when diagnosed with stage I NSCLC during 2011 to 2015. We used multivariate logistic regression models to determine factors associated with receiving timely therapy and receiving surgery versus stereotactic body radiation therapy (SBRT). We used multivariate Cox proportional hazards regression analysis to determine factors associated with overall mortality. Results: We identified 4796 Veterans with stage I NSCLC; the cohort was predominantly older, White males, current or former smokers, and living in urban areas. Overall, 84% underwent surgery and 16% underwent SBRT. The median time to treatment was 63 days (61 d for surgery; 71 d for SBRT), with 30% treated more than 12 weeks. Unmarried Veterans with higher social deprivation index were less likely to receive timely therapy. Black race, female sex, and never smoking were associated with lower overall mortality. Older Veterans receiving treatment >12 wk, with higher comorbidity index, and squamous cell carcinoma had higher overall mortality. Conclusions: A total of 30% of the Veterans with stage I NSCLC in the age group eligible for LCS received curative treatment more than 12 weeks after diagnosis, which was associated with higher overall mortality. Delays in LC treatment could decrease the mortality benefits of LCS among the Veterans.
Published: 2023
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43. Oral minocycline plus rifampicin versus oral linezolid for complicated skin and skin structure infections caused by methicillin-resistant Staphylococcus aureus: the AIDA open label, randomized, controlled Phase 4 trialResearch in context

Author: Antigone Kotsaki, Nikolaos Tziolos, Theano Kontopoulou, Ioannis M. Koutelidakis, Styliani Symbardi, Vaughan Reed, Miriam O'Hare, Zoi Alexiou, Helen Sambatakou, Konstantinos Toutouzas, Karolina Akinosoglou, Malvina Lada, Evangelos J. Giamarellos-Bourboulis, and Alasdair MacGowan
Subjects: Minocycline, Rifampicin, Linezolid, MRSA, Clincal trial, cSSI, Medicine (General), R5-920
Abstract: Summary: Background: The need for oral, cost-effective treatment for complicated skin and skin structure infections (cSSSIs) due to methicillin-resistant Staphylococcus aureus (MRSA) was addressed by the non-inferiority comparisons of oral minocycline plus rifampicin with linezolid. Methods: In the AIDA multicenter, open label, randomized, controlled clinical trial, hospitalized adults with cSSSI and documented MRSA were randomly assigned at a 2:1 ratio to either oral 600 mg rifampicin qd plus 100 mg minocycline bid or oral 600 mg linezolid bid for 10 days. The primary endpoint was the clinical cure rate in the clinically evaluable (CE) population at the test-of-cure visit (14 days). Non-inferiority was confirmed if the lower confidence limit (CI) did not fall below the accepted error margin of 15%. The study is registered with EudraCT number 2014-001276-56. Findings: 123 patients recruited between November 2014 and January 2017 were randomly assigned to treatment (81 patients to minocycline plus rifampicin and 42 patients to linezolid). Cure rates were 78.% (46/59, 90% CI 67.3–86.5) and 68.6% (24/35, 90% CI 53.4–81.3), respectively (P = 0.337). The percent difference in cure rates was 9.4% (90% CI −7.2 to 26.8%). Minocycline plus rifampicin combination was deemed non-inferior to linezolid as the lower CI was −7.2% i.e. smaller than the accepted error margin of −15%. Although statistically not significant, the overall rate of adverse events was higher in the linezolid group (47.6%, 20/42 versus 38.3%, 31/81). Interpretation: Oral minocycline plus rifampicin was non-inferior to oral linezolid treatment providing alternative oral treatment for cSSSI. Funding: The EU Seventh Research Framework Programme.
Published: 2023
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44. Detailed organisation of the human midbrain periaqueductal grey revealed using ultra-high field magnetic resonance imaging

Author: Fernando A Tinoco Mendoza, Timothy E S Hughes, Rebecca V Robertson, Lewis S Crawford, Noemi Meylakh, Paul M Macey, Vaughan G Macefield, Kevin A Keay, and Luke A Henderson
Subjects: Functional MRI, Pain, Brainstem, Periaqueductal grey, Somatotopy, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract: The midbrain periaqueductal grey (PAG) is a critical region for the mediation of pain-related behavioural responses. Neuronal tract tracing techniques in experimental animal studies have demonstrated that the lateral column of the PAG (lPAG) displays a crude somatotopy, which is thought to be critical for the selection of contextually appropriate behavioural responses, without the need for higher brain input. In addition to the different behavioural responses to cutaneous and muscle pain – active withdrawal versus passive coping – there is evidence that cutaneous pain is processed in the region of the lPAG and muscle pain in the adjacent ventrolateral PAG (vlPAG). Given the fundamental nature of these behavioural responses to cutaneous and muscle pain, these PAG circuits are assumed to have been preserved, though yet to be definitively documented in humans. Using ultra-high field (7-Tesla) functional magnetic resonance imaging we determined the locations of signal intensity changes in the PAG during noxious cutaneous heat stimuli and muscle pain in healthy control participants. Images were processed and blood oxygen level dependant (BOLD) signal changes within the PAG determined. It was observed that noxious cutaneous stimulation of the lip, cheek, and ear evoked maximal increases in BOLD activation in the rostral contralateral PAG, whereas noxious cutaneous stimulation of the thumb and toe evoked increases in the caudal contralateral PAG. Analysis of individual participants demonstrated that these activations were located in the lPAG. Furthermore, we found that deep muscular pain evoked the greatest increases in signal intensity in the vlPAG. These data suggest that the crude somatotopic organization of the PAG may be phyletically preserved between experimental animals and humans, with a body-face delineation capable of producing an appropriate behavioural response based on the location and tissue origin of a noxious stimulus.
Published: 2023
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45. Ethanol exposure alters Alzheimer's-related pathology, behavior, and metabolism in APP/PS1 mice

Author: Stephen M. Day, Stephen C. Gironda, Caitlin W. Clarke, J. Andy Snipes, Noelle I. Nicol, Hana Kamran, Warner Vaughan, Jeffrey L. Weiner, and Shannon L. Macauley
Subjects: Amyloid-β, Alcohol, Metabolism, Brain, Alzheimer's disease, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract: Epidemiological studies identified alcohol use disorder (AUD) as a risk factor for Alzheimer's disease (AD), yet there is conflicting evidence on how alcohol use promotes AD pathology. In this study, a 10-week moderate two-bottle choice drinking paradigm was used to identify how chronic ethanol exposure alters amyloid-β (Aβ)-related pathology, metabolism, and behavior. Ethanol-exposed APPswe/PSEN1dE9 (APP/PS1) mice showed increased brain atrophy and an increased number of amyloid plaques. Further analysis revealed that ethanol exposure led to a shift in the distribution of plaque size in the cortex and hippocampus. Ethanol-exposed mice developed a greater number of smaller plaques, potentially setting the stage for increased plaque proliferation in later life. Ethanol drinking APP/PS1 mice also exhibited deficits in nest building, a metric of self-care, as well as increased locomotor activity and central zone exploration in an open field test. Ethanol exposure also led to a diurnal shift in feeding behavior which was associated with changes in glucose homeostasis and glucose intolerance. Complementary in vivo microdialysis experiments were used to measure how acute ethanol directly modulates Aβ in the hippocampal interstitial fluid (ISF). Acute ethanol transiently increased hippocampal ISF glucose levels, suggesting that ethanol directly affects cerebral metabolism. Acute ethanol also selectively increased ISF Aβ40, but not ISF Aβ42, levels during withdrawal. Lastly, chronic ethanol drinking increased N-methyl-d-aspartate receptor (NMDAR) and decreased γ-aminobutyric acid type-A receptor (GABAAR) mRNA levels, indicating a potential hyperexcitable shift in the brain's excitatory/inhibitory (E/I) balance. Collectively, these experiments suggest that ethanol may increase Aβ deposition by disrupting metabolism and the brain's E/I balance. Furthermore, this study provides evidence that a moderate drinking paradigm culminates in an interaction between alcohol use and AD-related phenotypes with a potentiation of AD-related pathology, behavioral dysfunction, and metabolic impairment.
Published: 2023
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46. Dopamine transporter membrane mobility is bidirectionally regulated by phosphorylation and palmitoylation

Author: Madhur Shetty, Danielle E. Bolland, Joshua Morrell, Bryon D. Grove, James D. Foster, and Roxanne A. Vaughan
Subjects: Fluorescence recovery after photobleaching, FRAP, Protein kinase C, Mitogen activated protein kinase, Palmitoyl acyl transferase, DHHC2, Physiology, QP1-981, Specialties of internal medicine, RC581-951
Abstract: The primary regulator of dopamine availability in the brain is the dopamine transporter (DAT), a plasma membrane protein that drives reuptake of released dopamine from the extracellular space into the presynaptic neuron. DAT activity is regulated by post-translational modifications that establish clearance capacity through impacts on transport kinetics, and dysregulation of these events may underlie dopaminergic imbalances in mood and psychiatric disorders. Here, using fluorescence recovery after photobleaching, we show that phosphorylation and palmitoylation induce opposing effects on DAT lateral membrane mobility, which may influence functional outcomes by regulating subcellular localization and binding partner interactions. Membrane mobility was also impacted by amphetamine and in polymorphic variant A559V in directions consistent with enhanced phosphorylation. These findings grow the list of DAT properties controlled by these post-translational modifications and highlight their role in establishment of dopaminergic tone in physiological and pathophysiological states.
Published: 2023
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47. Understanding the physiology of the human vagus nerve from intraneural microelectrode recordings

Author: Vaughan Macefield, Mikaela Patros, Matteo Ottaviani, and Tye Dawood
Subjects: Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Published: 2023
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48. Stimulation of the dorsolateral prefrontal cortex modulates sympathetic nerve activity to muscle and skin in humans

Author: Vaughan Macefield, Gianni Sesa-Ashton, Rebecca Wong, Brendan McCarthy, Sudipta Datta, Luke Henderson, and Tye Dawood
Subjects: Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Published: 2023
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49. PERIOD 2 regulates low-dose radioprotection via PER2/pGSK3β/β-catenin/Per2 loop

Author: Aris T. Alexandrou, Yixin Duan, Shanxiu Xu, Clifford Tepper, Ming Fan, Jason Tang, Jonathan Berg, Wassim Basheer, Tyler Valicenti, Paul F. Wilson, Matthew A. Coleman, Andrew T. Vaughan, Loning Fu, David J. Grdina, Jefferey Murley, Aijun Wang, Gayle Woloschak, and Jian Jian Li
Subjects: Biological sciences, cell biology, molecular biology, Science
Abstract: Summary: During evolution, humans are acclimatized to the stresses of natural radiation and circadian rhythmicity. Radiosensitivity of mammalian cells varies in the circadian period and adaptive radioprotection can be induced by pre-exposure to low-level radiation (LDR). It is unclear, however, if clock proteins participate in signaling LDR radioprotection. Herein, we demonstrate that radiosensitivity is increased in mice with the deficient Period 2 gene (Per2def) due to impaired DNA repair and mitochondrial function in progenitor bone marrow hematopoietic stem cells and monocytes. Per2 induction and radioprotection are also identified in LDR-treated Per2wt mouse cells and in human skin (HK18) and breast (MCF-10A) epithelial cells. LDR-boosted PER2 interacts with pGSK3β(S9) which activates β-catenin and the LEF/TCF mediated gene transcription including Per2 and genes involved in DNA repair and mitochondrial functions. This study demonstrates that PER2 plays an active role in LDR adaptive radioprotection via PER2/pGSK3β/β-catenin/Per2 loop, a potential target for protecting normal cells from radiation injury.
Published: 2022
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50. Adolescent alcohol exposure reduces dopamine 1 receptor modulation of prelimbic neurons projecting to the nucleus accumbens and basolateral amygdala

Author: J. Daniel Obray, Justine D. Landin, Dylan T. Vaughan, Michael D. Scofield, and L. Judson Chandler
Subjects: Prelimbic cortex, Adolescence, Alcohol, Dopamine 1 receptor, Pyramidal neuron, Development, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract: Binge drinking during adolescence is highly prevalent despite increasing evidence of its long-term impact on behaviors associated with modulation of behavioral flexibility by the medial prefrontal cortex (mPFC). In the present study, male and female rats underwent adolescent intermittent ethanol (AIE) exposure by vapor inhalation. After aging to adulthood, retrograde bead labelling and viral tagging were used to identify populations of neurons in the prelimbic region (PrL) of the mPFC that project to specific subcortical targets. Electrophysiological recording from bead-labelled neurons in PrL slices revealed that AIE did not alter the intrinsic excitability of PrL neurons that projected to either the NAc or the BLA. Similarly, recordings of spontaneous inhibitory and excitatory post-synaptic currents revealed no AIE-induced changes in synaptic drive onto either population of projection neurons. In contrast, AIE exposure was associated with a loss of dopamine receptor 1 (D1), but no change in dopamine receptor 2 (D2), modulation of evoked firing of both populations of projection neurons. Lastly, confocal imaging of proximal and apical dendritic tufts of viral-labelled PrL neurons that projected to the nucleus accumbens (NAc) revealed AIE did not alter the density of dendritic spines. Together, these observations provide evidence that AIE exposure results in disruption of D1 receptor modulation of PrL inputs to at least two major subcortical target regions that have been implicated in AIE-induced long-term changes in behavioral control.
Published: 2022
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