1. Maternal and perinatal outcomes in high compared to low risk pregnancies complicated by severe acute respiratory syndrome coronavirus 2 infection (phase 2): the World Association of Perinatal Medicine working group on coronavirus disease 2019
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D'Antonio, Francesco, Sen, Cihat, Mascio, Daniele Di, Galindo, Alberto, Villalain, Cecilia, Herraiz, Ignacio, Arisoy, Resul, Ovayolu, Ali, Eroğlu, Hasan, Canales, Manuel Guerra, Ladella, Subhashini, Cojocaru, Liviu, Turan, Ozhan, Turan, Sifa, Hadar, Eran, Brzezinski-Sinai, Noa A, Dollinger, Sarah, Uyaniklar, Ozlem, Ocakouglu, Sakine Rahimli, Atak, Zeliha, Premru-Srsen, Tanja, Kornhauser-Cerar, Lilijana, Druškovič, Mirjam, Ples, Liana, Gündüz, Reyhan, Ağaçayak, Elif, Schvartzman, Javier Alfonso, Malbran, Mercedes Negri, Liberati, Marco, Sebastiano, Francesca Di, Oronzi, Ludovica, Cerra, Chiara, Buca, Danilo, Cagnacci, Angelo, Ramone, Arianna, Barra, Fabio, Carosso, Andrea, Benedetto, Chiara, Cosma, Stefano, Pintiaux, Axelle, Daelemans, Caroline, Costa, Elena, Özel, Ayşegül, Muhçu, Murat, Lopez, Jesús S Jimenez, Alvarado, Clara, Piqueras, Anna Luengo, Oliva, Dolores Esteban, Schera, Giovanni Battista Luca, Volpe, Nicola, Frusca, Tiziana, Samardjiski, Igor, Simeonova, Slagjana, Papestiev, Irena Aleksioska, Hojman, Javier, Turkcuoglu, Ilgin, Cromi, Antonella, Laganà, Antonio Simone, Ghezzi, Fabio, Sirico, Angelo, Familiari, Alessandra, Scambia, Giovanni, Sukhikh, Zulfiya Khodjaeva Gennady T, Gorina, Ksenia A, de Sa, Renato Augusto Moreira, Vaz, Mariana, Feuerschuette, Otto Henrique May, Gatta, Anna Nunzia Della, Youssef, Aly, Donna, Gaetana Di, Martinez-Varea, Alicia, Loscalzo, Gabriela, Morales Roselló, José, Stefanovic, Vedran, Nupponen, Irmeli, Nelskylä, Kaisa, Ayala, Rodrigo, Molpeceres, Rebeca Garrote, Vázquez, Asunción Pino, Sandri, Fabrizio, Cataneo, Ilaria, Lenzi, Marinella, Haberal, Esra Tustas, Huertas, Erasmo, Sanchez, Amadeo, Arango, Pedro, Bermejo, Amanda, Alcantara, María Monica Gonzalez, Göynümer, Gökhan, Okuyan, Erhan, Madalina, Ciuhodaru, Guisan, Ana Concheiro, Schulte, Alejandra Martínez, Esposito, Valentina, De Robertis, Valentina, Zdjelar, Snezana, Lackovic, Milan, Mihajlovic, Sladjana, Jekova, Nelly, Saccone, Gabriele, Aslan, Mehmet Musa, Dedda, Maria Carmela Di, Chalid, Maisuri, Canache, Jose Enrique Moros, Daskalakis, George, Antsaklis, Panos, Vega, Enrique Criado, Cueto, Elisa, Taccaliti, Chiara, Aykanat, Yeliz, Özlem Genç, Şerife, Froessler, Bernd, Radulova, Petya Angelova, Morano, Danila, Bianchi, Beatrice, Marino, Maria Giulia Lombana, Meccariello, Gabriella, Rohatgi, Bindu, Schiattarella, Antonio, Morlando, Maddalena, Colacurci, Nicola, Villasco, Andrea, Biglia, Nicoletta, Marques, Ana Luiza Santos, Gatti, Alessandra, Luvero, Daniela, Angioli, Roberto, Pittaro, Alejandro, Lila, Albert, Zlatohlávková, Blanka, On the behalf of the World Association of Perinatal Medicine working group on coronavirus disease 2019, Dicle Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kadın Hastalıkları ve Doğum Ana Bilim Dalı, Gündüz, Reyhan, Ağaçayak, Elif, [Belirlenecek], D'Antonio, F., Sen, C., Mascio, D. D., Galindo, A., Villalain, C., Herraiz, I., Arisoy, R., Ovayolu, A., Eroglu, H., Canales, M. G., Ladella, S., Cojocaru, L., Turan, O., Turan, S., Hadar, E., Brzezinski-Sinai, N. A., Dollinger, S., Uyaniklar, O., Ocakouglu, S. R., Atak, Z., Premru-Srsen, T., Kornhauser-Cerar, L., Druskovic, M., Ples, L., Gunduz, R., Agacayak, E., Schvartzman, J. A., Malbran, M. N., Liberati, M., Sebastiano, F. D., Oronzi, L., Cerra, C., Buca, D., Cagnacci, A., Ramone, A., Barra, F., Carosso, A., Benedetto, C., Cosma, S., Pintiaux, A., Daelemans, C., Costa, E., Ozel, A., Muhcu, M., Lopez, J. S. J., Alvarado, C., Piqueras, A. L., Oliva, D. E., Schera, G. B. L., Volpe, N., Frusca, T., Samardjiski, I., Simeonova, S., Papestiev, I. A., Hojman, J., Turkcuoglu, I., Cromi, A., Lagana, A. S., Ghezzi, F., Sirico, A., Familiari, A., Scambia, G., Sukhikh, Z. K. G. T., Gorina, K. A., de Sa, R. A. M., Vaz, M., Feuerschuette, O. H. M., Gatta, A. N. D., Youssef, A., Donna, G. D., Martinez-Varea, A., Loscalzo, G., Rosello, J. M., Stefanovic, V., Nupponen, I., Nelskyla, K., Ayala, R., Molpeceres, R. G., Vazquez, A. P., Sandri, F., Cataneo, I., Lenzi, M., Haberal, E. T., Huertas, E., Sanchez, A., Arango, P., Bermejo, A., Alcantara, M. M. G., Goynumer, G., Okuyan, E., Madalina, C., Guisan, A. C., Schulte, A. M., Esposito, V., De Robertis, V., Zdjelar, S., Lackovic, M., Mihajlovic, S., Jekova, N., Saccone, G., Aslan, M. M., Dedda, M. C. D., Chalid, M., Canache, J. E. M., Daskalakis, G., Antsaklis, P., Vega, E. C., Cueto, E., Taccaliti, C., Aykanat, Y., Ozlem Genc, S., Froessler, B., Radulova, P. A., Morano, D., Bianchi, B., Marino, M. G. L., Meccariello, G., Rohatgi, B., Schiattarella, A., Morlando, M., Colacurci, N., Villasco, A., Biglia, N., Marques, A. L. S., Gatti, A., Luvero, D., Angioli, R., Pittaro, A., Lila, A., and Zlatohlavkova, B.
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Neonatal intensive care unit ,coronavirus ,Miscarriage ,law.invention ,0302 clinical medicine ,Retrospective Studie ,law ,Pregnancy ,Neonatal ,Severe acute respiratory syndrome coronavirus 2 ,030212 general & internal medicine ,Pregnancy Complications, Infectious ,030219 obstetrics & reproductive medicine ,coronavirus disease 2019 ,infection ,pregnancy ,severe acute respiratory syndrome coronavirus 2 ,Asia ,Australia ,Europe ,Female ,Humans ,Infant, Newborn ,Intensive Care Units, Neonatal ,Retrospective Studies ,SARS-CoV-2 ,South America ,COVID-19 ,Pregnancy Outcome ,Coronavirus disease 2019 ,Obstetrics ,Incidence (epidemiology) ,Infectious ,General Medicine ,Intensive care unit ,3. Good health ,Intensive Care Units ,Covid-19 ,Infection ,Human ,medicine.medical_specialty ,03 medical and health sciences ,medicine ,business.industry ,Infant ,Retrospective cohort study ,Odds ratio ,medicine.disease ,Newborn ,Confidence interval ,coronaviru ,Pregnancy Complications ,Coronavirus ,Pregnancy Complications, Infectiou ,business - Abstract
BACKGROUND: It has still to be ascertained whether severe acute respiratory syndrome coronavirus 2 infection in pregnancy is associated with worse maternal and fetal outcomes compared to low risk gestations. OBJECTIVE: This study aimed to evaluate maternal and perinatal outcomes in high- and low-risk pregnancies complicated by severe acute respiratory syndrome coronavirus 2 infection. STUDY DESIGN: This was a multinational retrospective cohort study involving women with laboratory-confirmed severe acute respiratory syndrome coronavirus 2 infection from 76 centers from 25 countries in Europe, the United States, South America, Asia, and Australia from April 4, 2020, to October 28, 2020. The primary outcome was a composite measure of maternal mortality and morbidity, including admission to the intensive care unit, use of mechanical ventilation, or death. The secondary outcome was a composite measure of adverse perinatal outcome, including miscarriage, fetal loss, neonatal and perinatal death, and admission to the neonatal intensive care unit. All outcomes were assessed in high- and low-risk pregnancies. Pregnancies were considered high risk in case of either preexisting chronic medical conditions in pregnancy or obstetrical disorders occurring in pregnancy. The Fisher exact test and logistic regression analysis were used to analyze the data. RESULTS: A total of 887 singleton pregnancies who tested positive for severe acute respiratory syndrome coronavirus 2 infection using reverse transcription-polymerase chain reaction of nasal and pharyngeal swab specimens were included in the study. The risk of composite adverse maternal outcomes was higher in high-risk pregnancies than in low-risk pregnancies (odds ratio, 1.52; 95% confidence interval, 1.03-2.24; P=.035). In addition, women carrying high-risk pregnancies were at higher risk of hospital admission (odds ratio, 1.48; 95% confidence interval, 1.07-2.04; P=.002), presence of severe respiratory symptoms (odds ratio, 2.13; 95% confidence interval, 0.41-3.21; P=.001), admission to the intensive care unit (odds ratio, 2.63; 95% confidence interval, 1.42-4.88), and invasive mechanical ventilation (odds ratio, 2.65; 95% confidence interval, 1.19-5.94; P=.002). When exploring perinatal outcomes, high-risk pregnancies were at high risk of adverse perinatal outcomes (odds ratio, 1.78; 95% confidence interval, 0.15-2.72; P=.009). However, such association was mainly because of the higher incidence of miscarriage in high-risk pregnancies compared with that in low-risk pregnancies (5.3% vs 1.6%, P=.008); furthermore, there was no difference in other explored outcomes between the 2 study groups. At logistic regression analysis, maternal age (odds ratio, 1.12; 95% confidence interval, 1.02-1.22; P=.023) and high-risk pregnancy (odds ratio, 4.21; 95% confidence interval, 3.90-5.11; P
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- 2021