1. Chapter 13 Intracellular Regulation of Inwardly Rectifying Potassium Channels
- Author
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U. Brändle, Uwe Schulte, J. H. Schultz, J.P. Ruppersberg, and Bernd Fakler
- Subjects
Inward-rectifier potassium ion channel ,Potassium ,Protein subunit ,chemistry.chemical_element ,Multiple modes ,chemistry.chemical_compound ,chemistry ,Biochemistry ,ATP hydrolysis ,cardiovascular system ,Biophysics ,Sulfonylurea receptor ,Adenosine triphosphate ,Intracellular - Abstract
Publisher Summary This chapter provides an overview of the multiple modes of intracellular regulation of inwardly rectifying potassium (Kir) channels and provides some new insights into mechanisms and subunit specificity of the underlying molecular processes. Some types of intracellular regulation of Kir channels are complex: one example is dependence on adenosine triphosphate (ATP). While ATP dependence of Kir (KATP) channels is blocked by ATP without hydrolyzing it, in Kir2.l ATP hydrolysis reverses the spontaneous rundown. A similar process has also been described for Kir6.2 channels where it is independent of the presence of the regulatory sulfonylurea receptor (SUR) subunit. Chimeric channels constructed from Kir2.1 and Kirl.1 are analyzed in the chapter to define domains involved in this regulation. Even more complex is the regulation by oxidation and the effects of antioxidants that have been studied in Kir2.1 channels.
- Published
- 1999
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