6 results on '"Treu, Svenja"'
Search Results
2. Contributors
- Author
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Akram, Harith, primary, Al-Fatly, Bassam, additional, Alho, Eduardo Joaquim Lopes, additional, Baldermann, Juan Carlos, additional, Betzel, Richard F., additional, Boutet, Alexandre, additional, Butenko, K., additional, Choi, Ki Sueng, additional, Coenen, Volker A., additional, Deco, Gustavo, additional, Dembek, Till Anselm, additional, Dhollander, Thijs, additional, Elias, Gavin J.B., additional, Fernandes, Henrique M., additional, Ferreira, Francisca, additional, Fonoff, Erich Talamoni, additional, Fox, Michael D., additional, Germann, Jürgen, additional, Heinsen, Helmut, additional, Hertel, Frank, additional, Hollunder, Barbara, additional, Horn, Andreas, additional, Husch, Andreas, additional, Irmen, Friederike, additional, Jech, Robert, additional, Joutsa, Juho, additional, Krack, Paul, additional, Kringelbach, Morten L., additional, Kühn, Andrea A., additional, Lau, Jonathan C., additional, Li, Ningfei, additional, Lofredi, Roxanne, additional, Loh, Aaron, additional, Lozano, Andres M., additional, Mayberg, Helen, additional, Mueller, Karsten, additional, Neudorfer, Clemens, additional, Neumann, Wolf-Julian, additional, Oxenford, Simon, additional, Parmar, Roohie, additional, Perera, Thushara, additional, Rajamani, Nanditha, additional, Reisert, Marco, additional, van Rienen, U., additional, Shine, James M., additional, Siddiqi, Shan H., additional, Taha, Alaa, additional, Treu, Svenja, additional, Wong, Emily H.Y., additional, and Yang, Joseph Yuan-Mou, additional
- Published
- 2022
- Full Text
- View/download PDF
3. A ventromedial prefrontal dysrhythmia in obsessive-compulsive disorder is attenuated by nucleus accumbens deep brain stimulation
- Author
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Psicología, Treu, Svenja, González Rosa, Javier Jesús, Soto Leon, Vanesa, Lozano-Soldevilla, Diego, Oliviero, Antonio, López Sosa, Fernando, Reneses-Prieto, Blanca, Barcia, Juan A., Strange, Bryan A., Psicología, Treu, Svenja, González Rosa, Javier Jesús, Soto Leon, Vanesa, Lozano-Soldevilla, Diego, Oliviero, Antonio, López Sosa, Fernando, Reneses-Prieto, Blanca, Barcia, Juan A., and Strange, Bryan A.
- Abstract
Background: Obsessive-compulsive disorder (OCD) has consistently been linked to abnormal frontostriatal activity. The electrophysiological disruption in this circuit, however, remains to be characterized. Objective/hypothesis: The primary goal of this study was to investigate the neuronal synchronization in OCD patients. We predicted aberrant oscillatory activity in frontal regions compared to healthy control subjects, which would be alleviated by deep brain stimulation (DBS) of the nucleus accumbens (NAc). Methods: We compared scalp EEG recordings from nine patients with OCD treated with NAc-DBS with recordings from healthy controls, matched for age and gender. Within the patient group, EEG activity was compared with DBS turned off vs. stimulation at typical clinical settings (3.5 V, frequency of stimulation 130 Hz, pulse width 60 ms). In addition, intracranial EEG was recorded directly from depth macro electrodes in the NAc in four OCD patients. Results: Cross-frequency coupling between the phase of alpha/low beta oscillations and amplitude of high gamma was significantly increased over midline frontal and parietal electrodes in patients when stimulation was turned off, compared to controls. Critically, in patients, beta (16-25 Hz)-gamma (110-166 Hz) phase amplitude coupling source localized to the ventromedial prefrontal cortex, and was reduced when NAc-DBS was active. In contrast, intracranial EEG recordings showed no beta-gamma phase amplitude coupling. The contribution of non-sinusoidal beta waveforms to this coupling are reported. Conclusion: We reveal an increased beta-gamma phase amplitude coupling in fronto-central scalp sensors in patients suffering from OCD, compared to healthy controls, which may derive from ventromedial prefrontal regions implicated in OCD and is normalized by DBS of the nucleus accumbens. This aberrant cross-frequency coupling could represent a biomarker of OCD, as well as a target for novel therapeutic approaches. (C) 2021 The Author
- Published
- 2021
4. A Unified Functional Network Target for Deep Brain Stimulation in Obsessive-Compulsive Disorder.
- Author
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Li N, Hollunder B, Baldermann JC, Kibleur A, Treu S, Akram H, Al-Fatly B, Strange BA, Barcia JA, Zrinzo L, Joyce EM, Chabardes S, Visser-Vandewalle V, Polosan M, Kuhn J, Kühn AA, and Horn A
- Subjects
- Humans, Internal Capsule diagnostic imaging, Magnetic Resonance Imaging, Deep Brain Stimulation, Obsessive-Compulsive Disorder diagnostic imaging, Obsessive-Compulsive Disorder therapy, Subthalamic Nucleus
- Abstract
Background: Multiple deep brain stimulation (DBS) targets have been proposed for treating intractable obsessive-compulsive disorder (OCD). Here, we investigated whether stimulation effects of different target sites would be mediated by one common or several segregated functional brain networks., Methods: First, seeding from active electrodes of 4 OCD patient cohorts (N = 50) receiving DBS to anterior limb of the internal capsule or subthalamic nucleus zones, optimal functional connectivity profiles for maximal Yale-Brown Obsessive Compulsive Scale improvements were calculated and cross-validated in leave-one-cohort-out and leave-one-patient-out designs. Second, we derived optimal target-specific connectivity patterns to determine brain regions mutually predictive of clinical outcome for both targets and others predictive for either target alone. Functional connectivity was defined using resting-state functional magnetic resonance imaging data acquired in 1000 healthy participants., Results: While optimal functional connectivity profiles showed both commonalities and differences between target sites, robust cross-predictions of clinical improvements across OCD cohorts and targets suggested a shared network. Connectivity to the anterior cingulate cortex, insula, and precuneus, among other regions, was predictive regardless of stimulation target. Regions with maximal connectivity to these commonly predictive areas included the insula, superior frontal gyrus, anterior cingulate cortex, and anterior thalamus, as well as the original stereotactic targets., Conclusions: Pinpointing the network modulated by DBS for OCD from different target sites identified a set of brain regions to which DBS electrodes associated with optimal outcomes were functionally connected-regardless of target choice. On these grounds, we establish potential brain areas that could prospectively inform additional or alternative neuromodulation targets for obsessive-compulsive disorder., (Copyright © 2021 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.)
- Published
- 2021
- Full Text
- View/download PDF
5. Deep Brain Stimulation of the Nucleus Accumbens, Ventral Striatum, or Internal Capsule Targets for Medication-Resistant Obsessive-Compulsive Disorder: A Multicenter Study.
- Author
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Torres Díaz CV, Treu S, Strange B, Lara M, Navas M, Ezquiaga E, Zazo ES, Vicente JS, Muñiz I, and Fernandez FS
- Subjects
- Adult, Female, Humans, Male, Middle Aged, Obsessive-Compulsive Disorder physiopathology, Treatment Outcome, Young Adult, Deep Brain Stimulation, Internal Capsule physiopathology, Nucleus Accumbens physiopathology, Obsessive-Compulsive Disorder therapy, Ventral Striatum physiopathology
- Abstract
Background: Deep brain stimulation of the nucleus accumbens, ventral striatum, or internal capsule region has shown a 45%-60% response rate in adults with severe treatment-refractory obsessive-compulsive disorder, regardless of which target is used. We sought to improve the effectiveness of deep brain stimulation by placing the electrode along a trajectory including these 3 targets, enabling a change of stimulation site depending on the patient's response., Methods: This study used the medical records of 14 patients from 4 different Spanish institutions: 7 from the Hospital Universitario La Princesa, 3 from the Hospital Universitario Central de Asturias, 2 from Hospital Universitario Fundación Jiménez Díaz, and 2 from Hospital Universitari Son Espases. All patients were operated on under the same protocol. Qualitative and quantitative data were collected., Results: Of 14 patients, 11 showed significant improvement in obsessive-compulsive disorder symptoms, as evident in a reduction ≥35% in Yale-Brown Obsessive Compulsive Scale scores following stimulation relative to preoperative scores. Seven patients responded to stimulation at the nucleus accumbens (the first area we set for stimulation), whereas 4 patients needed to have the active contact switched to the internal capsule to benefit from stimulation., Conclusions: Deep brain stimulation of the nucleus accumbens, internal capsule, and ventral striatum significantly benefited our cohort of patients with medication-resistant obsessive-compulsive disorder. Electrode insertion through the 3 main targets might confer additional therapeutic efficacy., (Copyright © 2021 Elsevier Inc. All rights reserved.)
- Published
- 2021
- Full Text
- View/download PDF
6. A ventromedial prefrontal dysrhythmia in obsessive-compulsive disorder is attenuated by nucleus accumbens deep brain stimulation.
- Author
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Treu S, Gonzalez-Rosa JJ, Soto-Leon V, Lozano-Soldevilla D, Oliviero A, Lopez-Sosa F, Reneses-Prieto B, Barcia JA, and Strange BA
- Subjects
- Electrophysiological Phenomena, Frontal Lobe, Humans, Nucleus Accumbens, Deep Brain Stimulation, Obsessive-Compulsive Disorder therapy
- Abstract
Background: Obsessive-compulsive disorder (OCD) has consistently been linked to abnormal frontostriatal activity. The electrophysiological disruption in this circuit, however, remains to be characterized., Objective/hypothesis: The primary goal of this study was to investigate the neuronal synchronization in OCD patients. We predicted aberrant oscillatory activity in frontal regions compared to healthy control subjects, which would be alleviated by deep brain stimulation (DBS) of the nucleus accumbens (NAc)., Methods: We compared scalp EEG recordings from nine patients with OCD treated with NAc-DBS with recordings from healthy controls, matched for age and gender. Within the patient group, EEG activity was compared with DBS turned off vs. stimulation at typical clinical settings (3.5 V, frequency of stimulation 130 Hz, pulse width 60 μs). In addition, intracranial EEG was recorded directly from depth macroelectrodes in the NAc in four OCD patients., Results: Cross-frequency coupling between the phase of alpha/low beta oscillations and amplitude of high gamma was significantly increased over midline frontal and parietal electrodes in patients when stimulation was turned off, compared to controls. Critically, in patients, beta (16-25 Hz) -gamma (110-166 Hz) phase amplitude coupling source localized to the ventromedial prefrontal cortex, and was reduced when NAc-DBS was active. In contrast, intracranial EEG recordings showed no beta-gamma phase amplitude coupling. The contribution of non-sinusoidal beta waveforms to this coupling are reported., Conclusion: We reveal an increased beta-gamma phase amplitude coupling in fronto-central scalp sensors in patients suffering from OCD, compared to healthy controls, which may derive from ventromedial prefrontal regions implicated in OCD and is normalized by DBS of the nucleus accumbens. This aberrant cross-frequency coupling could represent a biomarker of OCD, as well as a target for novel therapeutic approaches., Competing Interests: Declaration of competing interest JAB has received travel and speaker honoraria from Medtronic and Boston Scientific. The rest of authors declare no conflicts of interest., (Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.)
- Published
- 2021
- Full Text
- View/download PDF
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