10 results on '"Tikkanen, Jani T."'
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2. Contributors
- Author
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Albakri, Aref, primary, AlMahameed, Soufian T., additional, Andršová, Irena, additional, Asirvatham, Samuel J., additional, Avari Silva, Jennifer N., additional, Bacharova, Ljuba, additional, Bagliani, Giuseppe, additional, Barakat, Rody, additional, Barakat, Michel M., additional, Barletta, Valentina, additional, Barthel, Petra, additional, Bébarová, Markéta, additional, Beck, Hiroko, additional, Belhassen, Bernard, additional, Bende, Girish, additional, Berkefeld, Anna, additional, Birgersdotter-Green, Ulrika, additional, Blinova, Ksenia, additional, Blomström-Lundqvist, Carina, additional, Bongiorni, Maria Grazia, additional, Brand, Thomas, additional, Bugiardini, Raffaele, additional, Bunch, T. Jared, additional, Castiglione, Alessandro, additional, Cenko, Edina, additional, Chatzidou, Sofia, additional, Chee, Jennifer, additional, Chelu, Mihail G., additional, Chen, Shih Ann, additional, Ciconte, Giuseppe, additional, Curtis, Anne B., additional, Curtis, Stephanie, additional, Cygankiewicz, Iwona, additional, Dalal, Aarti S., additional, Day, John D., additional, Della Tommasina, Veronica, additional, Deshmukh, Abhishek J., additional, Dilaveris, Polychronis, additional, Di Summa, Roberto, additional, Dogan, Mehmet, additional, Dong, Jun, additional, du Fay de Lavallaz, Jeanne, additional, Eckhardt, Lee L., additional, Efimova, Elena, additional, Ernst, Sabine, additional, Fawzy, Ameenathul M., additional, Gaita, Fiorenzo, additional, Garber, Libet, additional, Garnett, Christine, additional, Georgiopoulos, Georgios, additional, Gillis, Anne M., additional, Giustetto, Carla, additional, Gonzalez Corcia, M. Cecilia, additional, Haim, Moti, additional, Halliday, Brian P., additional, Hamdan, Mohamed H., additional, Hammersley, Daniel J., additional, Hartikainen, Juha E.K., additional, Haugaa, Kristina H., additional, Haukilahti, M. Anette E., additional, Hautala, Arto J., additional, Helánová, Kateřina, additional, Hnatkova, Katerina, additional, Hu, Yu-Feng, additional, Hu, Xiao, additional, Hurley, David, additional, Iwai, Sei, additional, Jacobs, Victoria, additional, Jacobson, Jason T., additional, James, Cynthia A., additional, Jiang, Hongying, additional, Jones, Camelle, additional, Jones, Richard E., additional, Junttila, M. Juhani, additional, Kadish, Alan H., additional, Karavirta, Laura, additional, Karim, Saima, additional, Karnad, Dilip, additional, Karunatilleke, Anne, additional, Kaufman, Elizabeth S., additional, Kenttä, Tuomas V., additional, Kezerle, Louise, additional, Khalil, Fouad M., additional, Klingenheben, Thomas, additional, Kloosterman, M., additional, Kontogiannis, Christos, additional, Kowlgi, Gurukripa N., additional, Kroman, Anne M., additional, Kutyifa, Valentina, additional, Lampert, Rachel, additional, Laukkanen, Jari, additional, Lee, Hyon Jae, additional, Leinveber, Pavel, additional, Leren, Ida S., additional, Lima, Fabio V., additional, Linde, Cecilia, additional, Locati, Emanuela T., additional, Macfarlane, Peter W., additional, Maclachlan, Hamish, additional, Mäkikallio, Timo H., additional, Malik, Marek, additional, Manfrini, Olivia, additional, Marashly, Qussay, additional, Margioula, Eleni, additional, McCaffrey, James A., additional, Mehra, Nandini S., additional, Milman, Anat, additional, Moharem-Elgamal, Sarah, additional, Mujović, Nebojša, additional, Nagarajan, Darbhamulla V., additional, Nemec, Petr, additional, Novotný, Tomáš, additional, O'Neill, Louisa, additional, Odening, Katja E., additional, Panicker, Gopi Krishna, additional, Pappone, Carlo, additional, Patton, Kristen K., additional, Pelter, Michele M., additional, Peyracchia, Mattia, additional, Potpara, Tratjana, additional, Powell, Benjamin E., additional, Preben, Bjerregaard, additional, Sarkozy, Andrea, additional, Schneider, Birke, additional, Segreti, Luca, additional, Selzman, Kimberly A., additional, Sharma, Sanjay, additional, Šišáková, Martina, additional, Spears, D.A., additional, Spera, Francesco Raffaele, additional, Špinarová, Lenka, additional, Stein, Phyllis K., additional, Stergiopoulos, Kathleen, additional, Sticherling, Christian, additional, Stuart, Graham, additional, Sugrue, Alan M., additional, Svennberg, Emma, additional, Tada, Hiroshi, additional, Tampakis, Konstantinos, additional, Tereshchenko, Larisa G., additional, Terho, Henri, additional, te Riele, Anneline S.J.M., additional, Tikkanen, Jani T., additional, Toman, Ondřej, additional, Toso, Elisabetta, additional, Tracy, Cynthia M., additional, Trifunovic, Danijela, additional, Turner, James M.A., additional, Vaidya, Vaibhav R., additional, Van Gelder, Isabelle C., additional, Vasavan, Tharni, additional, Verrier, Richard L., additional, Veseli, Granit, additional, Vicente, Jose, additional, Williamson, Catherine, additional, Wu, Wendy W., additional, YH. Lip, Gregory, additional, Younis, Arwa, additional, Zabel, Markus, additional, Zathar, Zafraan, additional, Zegre-Hemsey, Jessica K., additional, Zheng, Nan, additional, and Zucchelli, Giulio, additional
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- 2020
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3. Risk of sudden cardiac death associated with QRS, QTc, and JTc intervals in the general population.
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Tikkanen JT, Kentta T, Porthan K, Anttonen O, Eranti A, Aro AL, Kerola T, Rissanen HA, Knekt P, Heliövaara M, Holkeri A, Haukilahti A, Niiranen T, Hernesniemi J, Jula A, Nieminen MS, Myerburg RJ, Albert CM, Salomaa V, Huikuri HV, and Junttila MJ
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- Humans, Prognosis, Proportional Hazards Models, Risk Factors, Death, Sudden, Cardiac epidemiology, Death, Sudden, Cardiac etiology, Electrocardiography
- Abstract
Background: QRS duration and corrected QT (QTc) interval have been associated with sudden cardiac death (SCD), but no data are available on the significance of repolarization component (JTc interval) of the QTc interval as an independent risk marker in the general population., Objective: In this study, we sought to quantify the risk of SCD associated with QRS, QTc, and JTc intervals., Methods: This study was conducted using data from 3 population cohorts from different eras, comprising a total of 20,058 individuals. The follow-up period was limited to 10 years and age at baseline to 30-61 years. QRS duration and QT interval (Bazett's) were measured from standard 12-lead electrocardiograms at baseline. JTc interval was defined as QTc interval - QRS duration. Cox proportional hazards models that controlled for confounding clinical factors identified at baseline were used to estimate the relative risk of SCD., Results: During a mean period of 9.7 years, 207 SCDs occurred (1.1 per 1000 person-years). QRS duration was associated with a significantly increased risk of SCD in each cohort (pooled hazard ratio [HR] 1.030 per 1-ms increase; 95% confidence interval [CI] 1.017-1.043). The QTc interval had borderline to significant associations with SCD and varied among cohorts (pooled HR 1.007; 95% CI 1.001-1.012). JTc interval as a continuous variable was not associated with SCD (pooled HR 1.001; 95% CI 0.996-1.007)., Conclusion: Prolonged QRS durations and QTc intervals are associated with an increased risk of SCD. However, when the QTc interval is deconstructed into QRS and JTc intervals, the repolarization component (JTc) appears to have no independent prognostic value., (Copyright © 2022 Heart Rhythm Society. Published by Elsevier Inc. All rights reserved.)
- Published
- 2022
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4. Impact of age and sex on the long-term prognosis associated with early repolarization in the general population.
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Holkeri A, Eranti A, Haukilahti MAE, Kerola T, Kenttä TV, Tikkanen JT, Rissanen H, Heliövaara M, Knekt P, Junttila MJ, Aro AL, and Huikuri HV
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- Adult, Age Factors, Death, Sudden, Cardiac etiology, Female, Finland epidemiology, Follow-Up Studies, Humans, Incidence, Male, Middle Aged, Prognosis, Retrospective Studies, Risk Factors, Sex Factors, Survival Rate trends, Time Factors, Ventricular Fibrillation complications, Ventricular Fibrillation physiopathology, Death, Sudden, Cardiac epidemiology, Electrocardiography, Heart Conduction System physiopathology, Heart Rate physiology, Population Surveillance methods, Risk Assessment methods, Ventricular Fibrillation epidemiology
- Abstract
Background: Early repolarization (ER) has been linked to the risk of sudden cardiac death (SCD) in the general population, although controversy remains regarding risks across various subgroups., Objective: The purpose of this study was to investigate whether age and sex influence the prognostic significance of ER., Methods: We evaluated the 12-lead electrocardiograms of 6631 Finnish general population subjects age ≥30 years (mean age 50.1 ± 13.9 years; 44.5% men) for the presence of ER (J-point elevation ≥0.1 mV in ≥2 inferior/lateral leads) and followed them for 24.4 ± 10.3 years. We analyzed the association between ER and the risk of SCD, cardiac death, and all-cause mortality in subgroups according to age (<50 or ≥50 years) and sex., Results: ER was present in 367 of the 3305 subjects age <50 years and in 426 of 3326 subjects ≥50 years. ER was not associated with any of the endpoints in the entire study population. After adjusting for clinical factors, ER was associated with SCD (hazard ratio [HR] 1.88; 95% confidence interval [CI] 1.16-3.07) in subjects <50 but not in older subjects (interaction between ER and age group, P = .048). In the younger subgroup, women with ER had a high risk of SCD (HR 4.11; 95% CI 1.41-12.03), whereas among men ER was not associated with SCD. Finally, ER was not associated with cardiac mortality or all-cause mortality in either age group., Conclusion: ER is associated with SCD in subjects younger than 50 years, particularly in women, but not in subjects 50 years and older., (Copyright © 2019 Heart Rhythm Society. Published by Elsevier Inc. All rights reserved.)
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- 2020
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5. ECG left ventricular hypertrophy as a risk predictor of sudden cardiac death.
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Porthan K, Kenttä T, Niiranen TJ, Nieminen MS, Oikarinen L, Viitasalo M, Hernesniemi J, Jula AM, Salomaa V, Huikuri HV, Albert CM, and Tikkanen JT
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- Adult, Aged, Cohort Studies, Female, Follow-Up Studies, Health Surveys methods, Humans, Hypertrophy, Left Ventricular diagnosis, Male, Middle Aged, Predictive Value of Tests, Prospective Studies, Risk Factors, Death, Sudden, Cardiac epidemiology, Electrocardiography methods, Electrocardiography mortality, Hypertrophy, Left Ventricular mortality, Hypertrophy, Left Ventricular physiopathology
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Background: Electrocardiographic (ECG) left ventricular hypertrophy (LVH) is an established risk factor for cardiovascular events. However, limited data is available on the prognostic values of different ECG LVH criteria specifically to sudden cardiac death (SCD). Our goal was to assess relationships of different ECG LVH criteria to SCD., Methods: Three traditional and clinically useful (Sokolow-Lyon, Cornell, R
aVL ) and a recently proposed (Peguero-Lo Presti) ECG LVH voltage criteria were measured in 5730 subjects in the Health 2000 Survey, a national general population cohort study. Relationships between LVH criteria, as well as their selected composites, to SCD were analyzed with Cox regression models. In addition, population-attributable fractions for LVH criteria were calculated., Results: After a mean follow-up of 12.5 ± 2.2 years, 134 SCDs had occurred. When used as continuous variables, all LVH criteria except for RaVL were associated with SCD in multivariable analyses. When single LVH criteria were used as dichotomous variables, only Cornell was significant after adjustments. The dichotomous composite of Sokolow-Lyon and Cornell was also significant after adjustments (hazard ratio for SCD 1.82, 95% confidence interval 1.20-2.70, P = 0.006) and was the only LVH measure that showed statistically significant population-attributable fraction (11.0%, 95% confidence interval 1.9-19.2%, P = 0.019)., Conclusions: Sokolow-Lyon, Cornell, and Peguero-Lo Presti ECG, but not RaVL voltage, are associated with SCD risk as continuous ECG voltage LVH variables. When SCD risk assessment/adjustment is performed using a dichotomous ECG LVH measure, composite of Sokolow-Lyon and Cornell voltages is the preferred option., (Copyright © 2018 The Authors. Published by Elsevier B.V. All rights reserved.)- Published
- 2019
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6. Prediction of sudden cardiac death with automated high-throughput analysis of heterogeneity in standard resting 12-lead electrocardiograms.
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Kenttä TV, Nearing BD, Porthan K, Tikkanen JT, Viitasalo M, Nieminen MS, Salomaa V, Oikarinen L, Jula A, Kontula K, Newton-Cheh C, Huikuri HV, and Verrier RL
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- Adult, Aged, Aged, 80 and over, Arrhythmias, Cardiac diagnosis, Arrhythmias, Cardiac physiopathology, Female, Finland epidemiology, Humans, Male, Middle Aged, Predictive Value of Tests, Prognosis, Risk Factors, Survival Rate trends, Arrhythmias, Cardiac mortality, Death, Sudden, Cardiac epidemiology, Electrocardiography, Population Surveillance, Rest physiology, Risk Assessment methods
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Background: Heterogeneity of depolarization and repolarization underlies the development of lethal arrhythmias., Objective: We investigated whether quantification of spatial depolarization and repolarization heterogeneity identifies individuals at risk for sudden cardiac death (SCD)., Methods: Spatial R-, J-, and T-wave heterogeneity (RWH, JWH, and TWH, respectively) was analyzed using automated second central moment analysis of standard digital 12-lead electrocardiograms in 5618 adults (2588, 46% men; mean ± SEM age 50.9 ± 0.2 years), who took part in the epidemiological Health 2000 Survey as representative of the entire Finnish adult population., Results: During the follow-up period of 7.7 ± 0.2 years, a total of 72 SCDs occurred (1.3%), with an average yearly incidence rate of 0.17% per year. Increased RWH, JWH, and TWH in left precordial leads (V4-V6) were univariately associated with SCD (P < .001 for each). When adjusted with standard clinical risk markers, JWH and TWH remained independent predictors of SCD. Increased TWH (≥102 µV) was associated with a 1.7-fold adjusted relative risk for SCD (95% confidence interval [CI] 1.0-2.9; P = .048) and increased JWH (≥123 µV) with a 2.0-fold adjusted relative risk for SCD (95% CI 1.2-3.3; P = .006). When both TWH and JWH were above the threshold, the adjusted relative risk for SCD was 2.9-fold (95% CI 1.5-5.7; P = .002). When RWH (≥470 µV), JWH, and TWH were all above the threshold, the adjusted relative risk for SCD was 3.2-fold (95% CI 1.4-7.1; P = .009)., Conclusion: Second central moment analysis of standard resting 12-lead electrocardiographic morphology provides an ultrarapid means for the automated measurement of spatial RWH, JWH, and TWH, enabling analysis of high subject volumes and screening for SCD risk in the general population., (Copyright © 2016 Heart Rhythm Society. Published by Elsevier Inc. All rights reserved.)
- Published
- 2016
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7. Delayed QRS transition in the precordial leads of an electrocardiogram as a predictor of sudden cardiac death in the general population.
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Aro AL, Eranti A, Anttonen O, Kerola T, Rissanen HA, Knekt P, Porthan K, Tikkanen JT, Junttila MJ, and Huikuri HV
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- Adult, Age Distribution, Female, Finland epidemiology, Humans, Incidence, Kaplan-Meier Estimate, Male, Middle Aged, Population Surveillance, Predictive Value of Tests, Proportional Hazards Models, Retrospective Studies, Risk Assessment, Sex Distribution, Time Factors, Arrhythmias, Cardiac diagnosis, Arrhythmias, Cardiac mortality, Cause of Death, Death, Sudden, Cardiac epidemiology, Electrocardiography methods
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Background: QRS transition zone is related to the electrical axis of the heart in the horizontal plane and is easily determined from the precordial leads of a standard 12-lead ECG. However, whether delayed QRS transition, or clockwise rotation of the heart, carries prognostic implications and predicts sudden cardiac death (SCD) is unclear., Objective: The purpose of this study was to study whether delayed transition is associated with mortality and SCD., Methods: We evaluated 12-lead ECGs of 10,815 Finnish middle-aged subjects from the general population (52% men, mean age 44 ± 8.5 years) and followed them for 30 ± 11 years. Main end-points were mortality and SCD., Results: Delayed QRS transition at lead V4 or later occurred in 1770 subjects (16.4%) and markedly delayed transition at lead V5 or later in 146 subjects (1.3%). Delayed transition zone was associated with older age, male gender, higher body mass index, hypertension, baseline cardiovascular disease, leftward shift of the frontal QRS axis, wider QRS-T angle, and ECG left ventricular hypertrophy. After adjusting for several clinical and ECG variables, delayed transition was associated with overall mortality (hazard ratio [HR] 1.15, 95% confidence interval [CI] 1.07-1.22, P < .001) and SCD (HR 1.23, 95% CI 1.03-1.47, P = .029). Markedly delayed transition at V5 or later predicted significantly SCD (HR 1.89, 95% CI 1.18-3.03, P = .008) and all-cause mortality (HR 1.30, 95% CI 1.07-1.58, P = .01). However, further adjustments for repolarization abnormalities attenuated this effect., Conclusion: Delayed QRS transition in the precordial leads of an ECG seems to be a novel ECG risk marker for SCD. In particular, markedly delayed transition was associated with significantly increased risk of SCD, independent of confounding factors., (Copyright © 2014 Heart Rhythm Society. Published by Elsevier Inc. All rights reserved.)
- Published
- 2014
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8. Early repolarization as a predictor of arrhythmic and nonarrhythmic cardiac events in middle-aged subjects.
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Junttila MJ, Tikkanen JT, Kenttä T, Anttonen O, Aro AL, Porthan K, Kerola T, Rissanen HA, Knekt P, and Huikuri HV
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- Adult, Cause of Death trends, Confidence Intervals, Death, Sudden, Cardiac epidemiology, Female, Finland epidemiology, Follow-Up Studies, Forecasting, Heart Failure complications, Heart Failure mortality, Humans, Incidence, Male, Middle Aged, Prevalence, Prognosis, Proportional Hazards Models, Retrospective Studies, Risk Factors, Survival Rate trends, Tachycardia, Ventricular complications, Tachycardia, Ventricular mortality, Death, Sudden, Cardiac etiology, Electrocardiography, Heart Conduction System physiopathology, Heart Failure physiopathology, Heart Rate physiology, Risk Assessment methods, Tachycardia, Ventricular physiopathology
- Abstract
Background: Early repolarization (ER) in the inferior/lateral leads predicts mortality, but whether ER is a specific sign of increased risk for arrhythmic events is not known., Objective: The purpose of this study was to study the association of ER and arrhythmic events and nonarrhythmic morbidity and mortality., Methods: We assessed the prognostic significance of ER in a community-based general population of 10,846 middle-aged subjects (mean age 44 ± 8 years). The end-points were sustained ventricular tachycardia or resuscitated ventricular fibrillation (VT-VF), arrhythmic death, nonarrhythmic cardiac death, new-onset atrial fibrillation (AF), hospitalization for congestive heart failure, or coronary artery disease during mean follow-up of 30 ± 11 years. ER was defined as ≥0.1-mV elevation of J point in either inferior or lateral leads., Results: After including all risk factors of cardiac mortality and morbidity in Cox regression analysis, inferior ER (prevalence 3.5%) predicted VF-VT events (n = 108 [1.0%]) with a hazard ratio (HR) of 2.2 (95% confidence interval [CI] 1.1-4.5, P = .03) but not nonarrhythmic cardiac death (n = 1235 [12.2%]), AF (n = 1659 [15.2%]), congestive heart failure (n = 1752 [16.1%]), or coronary artery disease (n = 3592 [32.9%]) (P = NS for all). Inferior ER predicted arrhythmic death in cases without other QRS complex abnormalities (multivariate HR 1.68, 95 % CI 1.10-2.58, P = .02) but not in those with ER and other coexisting abnormalities in QRS morphology (HR 1.30, 95% CI 0.86-1.96, P = .22)., Conclusion: ER in the inferior leads, especially in cases without other QRS complex abnormalities, predicts the occurrence of VT-VF but not nonarrhythmic cardiac events, suggesting that ER is a specific sign of increased vulnerability to ventricular tachyarrhythmias., (Copyright © 2014 Heart Rhythm Society. Published by Elsevier Inc. All rights reserved.)
- Published
- 2014
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9. A meta-analysis of genome-wide association studies of the electrocardiographic early repolarization pattern.
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Sinner MF, Porthan K, Noseworthy PA, Havulinna AS, Tikkanen JT, Müller-Nurasyid M, Peloso G, Ulivi S, Beckmann BM, Brockhaus AC, Cooper RR, Gasparini P, Hengstenberg C, Hwang SJ, Iorio A, Junttila MJ, Klopp N, Kähönen M, Laaksonen MA, Lehtimäki T, Lichtner P, Lyytikäinen LP, Martens E, Meisinger C, Meitinger T, Merchant FM, Nieminen MS, Peters A, Pietilä A, Perz S, Oikarinen L, Raitakari O, Reinhard W, Silander K, Thorand B, Wichmann HE, Sinagra G, Viikari J, O'Donnell CJ, Ellinor PT, Huikuri HV, Kääb S, Newton-Cheh C, and Salomaa V
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- Female, Genetic Predisposition to Disease, Humans, Male, Mutation, Phenotype, Polymorphism, Single Nucleotide, Risk Factors, Arrhythmias, Cardiac genetics, Death, Sudden, Cardiac, Electrocardiography, Genome-Wide Association Study, Heart Conduction System physiopathology
- Abstract
Background: The early repolarization pattern (ERP) is common and associated with risk of sudden cardiac death. ERP is heritable, and mutations have been described in syndromatic cases., Objective: To conduct a meta-analysis of genome-wide association studies to identify common genetic variants influencing ERP., Methods: We ascertained ERP on the basis of electrocardiograms in 3 large community-based cohorts from Europe and the United States: the Framingham Heart Study, the Health 2000 Study, and the KORA F4 Study. We analyzed genome-wide association studies in participants with and without ERP by logistic regression assuming an additive genetic model and meta-analyzed individual cohort results. We then sought to strengthen support for findings that reached P ≤ 1 × 10(-5) in independent individuals by direct genotyping or in-silico analysis of genome-wide data. We meta-analyzed the results from both stages., Results: Of 7482 individuals in the discovery stage, 452 showed ERP (ERP positive: mean age 46.9 ± 8.9 years, 30.3% women; ERP negative: 47.5 ± 9.4 years, 54.2% women). After meta-analysis, 8 single nucleotide polymorphisms reached P ≤ 1 × 10(-5): The most significant finding was intergenic rs11653989 (odds ratio 0.47; 95% confidence interval 0.36-0.61; P = 6.9 × 10(-9)). The most biologically relevant finding was intronic to KCND3: rs17029069 (odds ratio 1.46; 95% confidence interval 1.25-1.69; P = 8.5 × 10(-7)). In the replication step (7151 individuals), none of the 8 variants replicated, and combined meta-analysis results failed to reach genome-wide significance., Conclusions: In a genome-wide association study, we were not able to reliably identify genetic variants predisposing to ERP, presumably due to insufficient statistical power and phenotype heterogeneity. The reported heritability of ERP warrants continued investigation in larger well-phenotyped populations., (Copyright © 2012 Heart Rhythm Society. All rights reserved.)
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- 2012
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10. Causes of nonischemic sudden cardiac death in the current era.
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Hookana E, Junttila MJ, Puurunen VP, Tikkanen JT, Kaikkonen KS, Kortelainen ML, Myerburg RJ, and Huikuri HV
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- Adult, Alcoholism complications, Alcoholism epidemiology, Analysis of Variance, Autopsy, Cardiomyopathies complications, Cardiomyopathies epidemiology, Cardiovascular Diseases complications, Cardiovascular Diseases epidemiology, Cause of Death, Chi-Square Distribution, Female, Finland epidemiology, Humans, Hypertension complications, Hypertension epidemiology, Life Style, Male, Middle Aged, Obesity complications, Obesity epidemiology, Prevalence, Risk Factors, Surveys and Questionnaires, Death, Sudden, Cardiac etiology
- Abstract
Background: Previous data have shown that various nonischemic cardiac diseases account for about 20% of sudden cardiac deaths (SCDs) and that dilated and hypertrophic cardiomyopathy (CM) are major causes of nonischemic SCD., Objective: The purpose of this study was to define the prevalence and causes of SCD due to nonischemic CM in the current era given the substantial change in the diagnosis and treatment of cardiac diseases and in lifestyle patterns., Methods: A total of 2661 consecutive victims of SCD from among a population of approximately 470,000 inhabitants in the Province of Oulu, Northern Finland, were included in the study. The causes of deaths were determined from the uniformly required autopsies of SCD victims in Finland, plus available medical records and standardized questionnaires., Results: Nonischemic cause of SCD was found in 579 victims (21.8% of all the SCDs). Mean age (± SD) was 55 (±12) years; 78% were males. After subgrouping the nonischemic SCDs into various categories, SCDs associated most closely with obesity (23.7%), followed by alcoholic CM (19.0%), hypertensive CM (15.5%), and fibrotic CM (13.6%). Fibrotic CM was the most common association with SCD in subjects younger than 40 years (28.3%), whereas alcoholic CM was the most common cause of death in subjects between 40 and 59 years of age (25.8%)., Conclusion: CM related to obesity, fibrotic CM, and alcoholic CM are commonly associated with nonischemic SCD in the current era. The association of SCD with fibrotic CM is notably frequent among victims younger than 40 years., (Copyright © 2011 Heart Rhythm Society. Published by Elsevier Inc. All rights reserved.)
- Published
- 2011
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