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Plasmablastic lymphoma (PBL) is a rare and aggressive non- Hodgkin 's B-cell lymphoma initially reported in patients with the HIV virus with a predilection for the oral cavity. It can affect individuals with other types of immunodeficiency and appear in extra-oral sites, also demonstrating an association with Epstein-Barr Virus (EBV) infection. Histopathological diagnosis is challenging due to overlapping features of other high-grade lymphomas and plasma cell lesions. The objective of the study was to report two cases of oral manifestations of Plasmablastic Lymphoma, in a patient with different HIV serological status and EBV positivity, aiming to present and discuss information regarding the clinical presentation, laboratory and immunohistochemical findings, proposed treatment and a review of updated literature on the topic.

Angiosarcomas are rare and aggressive malignant tumors of endothelial cells, they have a vascular or lymphatic origin. Diagnostic evaluation includes a biopsy to confirm the histopathological diagnosis, in addition to magnetic resonance imaging to delineate the extent of the primary lesion before surgery. We report an unusual clinical event of well-differentiated angiosarcoma in the nasogingival labial region in a female patient, 85-years-old, who sought care with increased sensitivity in the upper lip with progressive worsening and the appearance of pain and local edema. After a biopsy and immunohistochemical study, she was diagnosed with well-differentiated nasogingivolabial angiosarcoma. The patient underwent extensive surgical resection of the lesion with nasal amputation, resection of the upper lip, and partial palatectomy associated with postoperative radiotherapy. Then, she was referred to the oral and maxillofacial prosthesis service for rehabilitation. The patient was diagnosed with advanced stage metastasis in the liver 25 months after the surgical treatment, being under palliative care. Eight months later, the patient died. We also present a discussion of clinical and histopathological aspects, differential diagnosis and treatment modalities, In addition to a brief review of the literature on the subject.

Introduction: Periodontitis, a complex infectious disease that may lead to irreversible loss of periodontium, is considered a predisposing agent for developing insulin resistance due to the release of inflammatory mediators, showing a bilateral relationship with diabetes mellitus. The investigation of periodontal disease requires a clinical approach and complete intraoral radiographs, even with increasing concerns about radiation exposure. Thus, this study assesses pixel linear analysis accuracy using digital radiography via Digora® in detecting alveolar bone destruction in diabetic rats with periodontal disease. Methodology: 40 rats were divided into groups (n = 10): control (C), rats with periodontal disease (PD), experimental diabetic rats (ED), experimental diabetic rats with periodontal disease (ED-PD). Diabetes was induced by streptozotocin and periodontal disease by periodontal ligature. After 30 days, maxillae bone destruction was obtained by linear analysis of vertical bone loss using digital radiography and then assessed by micro-CT and histology. Data were analyzed by ANOVA and Tukey’s test (p

Background: Maxillary sinus mucocele is a benign cystic lesion caused due to mucus retention. The aim of this article is to relate a singular case of MSM development after dental extraction. We believe that previous dental extraction procedure of teeth 26, must have established some degree of Oroantral Comunnication, allowing the maxillary sinus epithelial inclusion into the alveolar socket. Case presentation: A 32-year-old male patient presented to the Oral Medicine service in the authors’ institution, with a chief complaint of left-sided facial swelling with slow growth and development for 2 years. Intra oral examination revealed a symptomatic circumscribed lesion of approximately 5–6 cm without mobility, firm on palpation, located in the vestibular sulcus on left-sided maxilla. It was situated in the region between teeth 25 to 27, with the teeth 26 being absent The lateral wall was surgically removed from the cystic cavity, followed by conservative decompression allowing gradual pneumatization of the maxillary sinus. The lesion response comprised regression in size, swelling, and pain, preserving the affected site and benefiting the patient with possible rehabilitation in the future. At the 2-year follow-up, the patient reported no complications. Conclusion: This study case demonstrated that MSM could be confused with tumors from an odontogenic nature, sometimes presenting an aggressive growth pattern. Although numerous treatment modalities exist for the treatment of MSM, the conservative technique promotes effective tissue preservation and benefits to the patient.