Author: "Taylor EC" / Publisher: elsevier - Searchworks@Jio Institute Digital Library Search Results

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Author: Palmer DC, Skotnicki JS, and Taylor EC
Subjects: Aminopterin chemical synthesis, Folic Acid chemical synthesis, Methotrexate chemical synthesis, Molecular Structure, Aminopterin analogs & derivatives, Antineoplastic Agents chemical synthesis, Folic Acid analogs & derivatives, Methotrexate analogs & derivatives
Published: 1988
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Author: Kovacic P, Ames JR, Taylor EC, and Ryan MD
Subjects: Chemical Phenomena, Chemistry, Electrochemistry, Hydrogen-Ion Concentration, Pyridoxal Phosphate analysis, Eflornithine analysis, Methotrexate analysis
Abstract: The electrochemical characteristics of the antitumor agents methotrexate and alpha-difluoromethylornithine were determined as their iminium derivatives. Iminium formation from methotrexate is accomplished in vivo via protonation by enzyme. The requisite imine precursor is generated from alpha-difluoromethylornithine by condensation with enzyme containing pyridoxal phosphate. Electroreduction occurs in the range of -0.2 to -0.6 V. The relationship of reduction to structure is discussed. A possible mode of anticancer action involving electron transfer is presented.
Published: 1988
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