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6 results on '"Susan D Reynolds"'

1. MALDI imaging MS of phospholipids in the mouse lung[S]

Author

Robert C. Murphy, Peter M. Henson, Susan D. Reynolds, Bilan Li, Miguel A. Gijón, Joseph A. Hankin, Robert M. Barkley, and Karin A. Zemski Berry

Subjects
MALDI imaging, Docosahexaenoic Acids, Fluorescent Antibody Technique, lipid mediators, QD415-436, Biology, lipid localization, pulmonary tissue, Biochemistry, Mice, chemistry.chemical_compound, Endocrinology, Parenchyma, medicine, arachidonic acid, Animals, Lipid localization, Lung, Research Articles, Phospholipids, mass spectrometry, Lipid metabolism, Cell Biology, respiratory system, Lipid Metabolism, Sphingomyelins, respiratory tract diseases, Mice, Inbred C57BL, cryoembedding agent, medicine.anatomical_structure, chemistry, Docosahexaenoic acid, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Blood Vessels, Arachidonic acid, lipids (amino acids, peptides, and proteins), Sphingomyelin
Abstract

Lipid mediators are important in lung biochemistry and are derived from the enzymatic oxidation of arachidonic and docosahexaenoic acids, which are PUFAs that are present in phospholipids in cell membranes. In this study, MALDI imaging MS was used to determine the localization of arachidonate- and docosahexaenoate-containing phospholipids in mouse lung. These PUFA-containing phospholipids were determined to be uniquely abundant at the lining of small and large airways, which were unequivocally identified by immunohistochemistry. In addition, it was found that the blood vessels present in the lung were characterized by sphingomyelin molecular species, and lung surfactant phospholipids appeared evenly distributed throughout the lung parenchyma, indicating alveolar localization. This technique revealed unexpected high concentrations of arachidonate- and docosahexaenoate-containing phospholipids lining the airways in pulmonary tissue, which could serve as precursors of lipid mediators affecting airways biology.

Published
2011

2. List of Contributors

Author

Saurabh Aggarwal, Jason H.T. Bates, Stephen M. Black, Peter F. Bove, James S. Brown, Jared M. Brown, Gary R. Burleson, Stefanie C.M. Burleson, Florence G. Burleson, Alejandro Castañeda, James F. Collawn, Donald N. Cook, Daniel L. Costa, Elvira C. Covarrubias, James D. Crapo, Albert van der Vliet, Aimen K. Farraj, Jane E. Farrington, Robert B. Fick, Aron B. Fisher, Henry J. Forman, W. Michael Foster, Peter Gehr, Andrew J. Gow, Christine M. Gross, Ryan Hadley, Jack R. Harkema, Mehdi Saeed Hazari, Daniel Hirsch, Dallas M. Hyde, Victor J. Johnson, James H. Jones, Pranita Katwa, Murat Kaynar, Debra L. Laskin, Jeffrey D. Laskin, Hui-Hua Li, James D. Londino, Kim E. Longworth, Michael I. Luster, Rama Malaviya, Mark D. Mannie, Andrew T. Mariassy, Sadis Matalon, Stephanie A. Matthes, John T. McBride, Robert R. Mercer, John B. Morris, Hideki Nakano, Stephen G. Olmstead, Janice L. Peake, Kent E. Pinkerton, Bruce R. Pitt, Charles G. Plopper, Robert J. Porcelli, Scott H. Randell, Susan D. Reynolds, Jesse Roman, Philip L. Sannes, Rashmin C. Savani, Richard B. Schlesinger, Madhuri Singal, Suzette Smiley-Jewell, Bernd W. Spur, Claudette M. St. Croix, Judith A. St. George, Jeffrey S. Tepper, Kalidasan Thambiayya, Michael R. Van Scott, Laura S. Van Winkle, Peter D. Wagner, Karla A. Wasserloos, Barry Weinberger, Eric S. White, Kingsley Yin, Berran Yucesoy, and Graeme R. Zosky

Published
2015

3. Epithelial Cells of Trachea and Bronchi

Author

Susan D. Reynolds, Andrew T. Mariassy, and Kent E. Pinkerton

Subjects
Brush Cell, business.industry, Cough reflex, Parenchyma, Medicine, Anatomy, respiratory system, Inhaled air, business, respiratory tract diseases
Abstract

The trachea, bronchi, and bronchioles constitute the branched conduit for transport of gases to and from the lung parenchyma. The airways regulate the flow and condition the inhaled air. To accomplish these tasks, mammalian airways have acquired a number of adaptive mechanisms and functions, which are reflected in their structure.

Published
2015

4. Injury and Repair of the Lung

Author

Gregory P. Downey, Peter M. Henson, Marc Moss, and Susan D. Reynolds

Subjects
Pathology, medicine.medical_specialty, Lung, medicine.anatomical_structure, business.industry, medicine, Injury and repair, business
Published
2010

5. Contributors

Author

Lewis Adams, Anthony J. Alberg, Richard K. Albert, Kurt H. Albertine, Devanand Anantham, Douglas Arenberg, Najib T. Ayas, Ronald C. Balkissoon, John R. Balmes, Srinivas R. Bapoje, Joan Albert Barberà, Peter J. Barnes, Fuad M. Baroody, Margaret R. Becklake, Joshua O. Benditt, Neal L. Benowitz, Paul D. Blanc, Richard C. Boucher, Alfred A. Bove, Elisabeth Brambilla, V. Courtney Broaddus, Kevin K. Brown, Paul G. Brunetta, Jacques Cadranel, David P. Carbone, Bartolome R. Celli, Edward D. Chan, Moira Chan-Yeung, Richard N. Channick, Jean Chastre, Kian Fan Chung, Maria Cirino-Marcano, R. Edward Coleman, Harold R. Collard, Carlyne D. Cool, Jean-François Cordier, Tamera J. Corte, Vincent Cottin, Robert L. Cowie, Robert O. Crapo, Kristina Crothers, Charles L. Daley, Scott F. Davies, Teresa De Marco, Lorenzo Del Sorbo, Gregory P. Downey, Wonder Drake, Roland M. du Bois, James Duffin, Richard M. Effros, Mark D. Eisner, Brett M. Elicker, Armin Ernst, Peter F. Fedullo, Matthew J. Fenton, Daniel Fertel, Hans G. Folkesson, Rodney J. Folz, Andrew P. Fontenot, Joe G.N. Garcia, Gerald F. Gebhart, Thomas J. Giordano, Nicolas Girard, Mark T. Gladwin, Michael B. Gotway, James M. Greenberg, David E. Griffith, Stephen Groshong, Matthew J. Hegewald, Peter M. Henson, Nicholas S. Hill, Philip C. Hopewell, Laurence Huang, Yoshikazu Inoue, Michael D. Iseman, James E. Jackson, Jeffrey R. Jacobson, James R. Jett, Demet Karnak, Midori Kato-Maeda, Mani S. Kavuru, Talmadge E. King, Michael R. Knowles, Kenneth S. Knox, Robert M. Kotloff, Monica Kraft, Elif Kupeli, Stephen E. Lapinsky, Abigail R. Lara, Stephen C. Lazarus, F. Eun-Hyung Lee, Warren L. Lee, Y.C. Gary Lee, Teofilo Lee-Chiong, James F. Lewis, Richard W. Light, Andrew H. Limper, Robert Loddenkemper, John M. Luce, Njira Lugogo, Andrew M. Luks, Charles-Edouard Luyt, Roberto F. Machado, Neil R. MacIntyre, Lisa A. Maier, Fabien Maldonado, Jean-Luc Malo, Erica L. Martin, Thomas R. Martin, Robert J. Mason, Pierre P. Massion, Michael A. Matthay, Richard A. Matthay, Annyce S. Mayer, James McCarthy, F. Dennis McCool, Francis X. McCormack, Dana McGlothlin, Atul C. Mehta, Rosario Menéndez, Alison Morris, Timothy A. Morris, Lake D. Morrison, Marc Moss, Jill Murray, John F. Murray, Jeffrey L. Myers, Jay A. Nadel, Koh Nakata, Thomas S. Neuman, Lee S. Newman, Paul W. Noble, Marc Noppen, Thomas B. Nutman, Thomas G. O’Riordan, Allan I. Pack, Peter D. Paré, David R. Park, Edward F. Patz, Eliot A. Phillipson, Allan Pickens, Grace W. Pien, Frank L. Powell, Bobbi S. Pritt, Loretta G. Que, V. Marco Ranieri, John J. Reilly, Stephen I. Rennard, Susan D. Reynolds, David W.H. Riches, Norman W. Rizk, Bruce W.S. Robinson, Roberto Rodriguez-Roisin, Cecile S. Rose, Charis Roussos, John M. Routes, Lewis J. Rubin, Jonathan M. Samet, Christian Sandrock, George A. Sarosi, Richard T. Sawyer, Gregory A. Schmidt, Robert B. Schoene, Dean E. Schraufnagel, David A. Schwartz, Richard M. Schwartzstein, Marvin I. Schwarz, Moises Selman, John M. Shannon, Steven D. Shapiro, Kenneth E. Shepherd, Claire L. Shovlin, Kathy E. Sietsema, Gerard A. Silvestri, Philip L. Simonian, Arthur S. Slutsky, Gerald C. Smaldone, Eugene J. Sullivan, Erik R. Swenson, Alkis Togias, Antoni Torres, Bruce C. Trapnell, John Treanor, Rubin M. Tuder, George E. Tzelepis, Eric Vallières, Peter D. Wagner, Scott T. Weiss, Athol U. Wells, John B. West, Douglas B. White, John G. Widdicombe, Jeanine P. Wiener-Kronish, Richard Wunderink, James R. Yankaskas, Joseph D.C. Yao, Spyros G. Zakynthinos, Leslie Zimmerman, and Richard L. ZuWallack

Published
2010

6. MALDI imaging MS of phospholipids in the mouse lung[S]

Author

Karin A. Zemski Berry, Bilan Li, Susan D. Reynolds, Robert M. Barkley, Miguel A. Gijón, Joseph A. Hankin, Peter M. Henson, and Robert C. Murphy

Subjects
arachidonic acid, lipid localization, cryoembedding agent, lipid mediators, pulmonary tissue, mass spectrometry, Biochemistry, QD415-436
Abstract

Lipid mediators are important in lung biochemistry and are derived from the enzymatic oxidation of arachidonic and docosahexaenoic acids, which are PUFAs that are present in phospholipids in cell membranes. In this study, MALDI imaging MS was used to determine the localization of arachidonate- and docosahexaenoate-containing phospholipids in mouse lung. These PUFA-containing phospholipids were determined to be uniquely abundant at the lining of small and large airways, which were unequivocally identified by immunohistochemistry. In addition, it was found that the blood vessels present in the lung were characterized by sphingomyelin molecular species, and lung surfactant phospholipids appeared evenly distributed throughout the lung parenchyma, indicating alveolar localization. This technique revealed unexpected high concentrations of arachidonate- and docosahexaenoate-containing phospholipids lining the airways in pulmonary tissue, which could serve as precursors of lipid mediators affecting airways biology.

Published
2011
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