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7 results on '"Susan C. Nicolson"'

1. Electroencephalography as a tool to predict cerebral oxygen metabolism during deep-hypothermic circulatory arrest in neonates with critical congenital heart diseaseCentral MessagePerspective

Author

Gerard H. Laurent, ScB, Tiffany S. Ko, PhD, Kobina G. Mensah-Brown, MD, MS, Constantine D. Mavroudis, MD, MSC, MTR, Marin Jacobwitz, CRNP, PhD, Nicolina Ranieri, BSc, Susan C. Nicolson, MD, J. William Gaynor, MD, Wesley B. Baker, PhD, Daniel J. Licht, MD, Shavonne L. Massey, MD, MSCE, and Jennifer M. Lynch, MD, PhD

Subjects
cardiopulmonary bypass, cerebral oxygen extraction fraction, cerebral oxygen saturation, congenital heart disease, deep hypothermic circulatory arrest, neonate, Diseases of the circulatory (Cardiovascular) system, RC666-701, Surgery, RD1-811
Abstract

Objectives: Recent research suggests that increased cerebral oxygen use during surgical intervention for neonates with congenital heart disease may play a role in the development of postoperative white matter injury. The objective of this study is to determine whether increased cerebral electrical activity correlates with greater decrease of cerebral oxygen saturation during deep hypothermic circulatory arrest. Methods: Neonates with critical congenital heart disease requiring surgical intervention during the first week of life were studied. All subjects had continuous neuromonitoring with electroencephalography and an optical probe (to quantify cerebral oxygen saturation) during cardiac surgical repair that involved the use of cardiopulmonary bypass and deep hypothermic circulatory arrest. A simple linear regression was used to investigate the association between electroencephalography metrics before the deep hypothermic circulatory arrest period and the change in cerebral oxygen saturation during the deep hypothermic circulatory arrest period. Results: Sixteen neonates had both neuromonitoring modalities attached during surgical repair. Cerebral oxygen saturation data from 5 subjects were excluded due to poor data quality, yielding a total sample of 11 neonates. A simple linear regression model found that the presence of electroencephalography activity at the end of cooling is positively associated with the decrease in cerebral oxygen saturation that occurs during deep hypothermic circulatory arrest (P

Published
2023
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2. Effect of parental origin of damaging variants in pro-angiogenic genes on fetal growth in patients with congenital heart defects: Data and analyses

Author

Mark W. Russell, Julie S. Moldenhauer, Jack Rychik, Nancy B. Burnham, Erin Zullo, Samuel I. Parry, Rebecca A. Simmons, Michal A. Elovitz, Susan C. Nicolson, Rebecca L. Linn, Mark P. Johnson, Sunkyung Yu, Matthew G. Sampson, Hakon Hakonarson, and J. William Gaynor

Subjects
Computer applications to medicine. Medical informatics, R858-859.7, Science (General), Q1-390
Abstract

The placenta is a highly vascular structure composed of both maternal and fetal elements. We have determined that damaging variants in genes responsible for the positive regulation of angiogenesis (PRA) (GO:0045766) that are inherited by the fetus impair fetal growth and placental function in pregnancies involving critical congenital cardiac defects (Russell et al., 2019). In this dataset, we present the specific genetic variants identified, describe the parental origin of each variant where possible and present the analyses regarding the potential effects of parental origin of the variant on placental function and fetal growth. The data presented are related to the research article “Damaging variants in pro-angiogenic genes impair growth in fetuses with cardiac defects” (Russell et al., 2019). Keywords: Genetic variation, Placental function, Fetal growth, Congenital cardiac defects

Published
2019
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4. Results of a phase 1 multicentre investigation of dexmedetomidine bolus and infusion in corrective infant cardiac surgery

Author

Juan C. Ibla, Athena F. Zuppa, Hua Ni, Felicia L. Trachtenberg, Mario Stylianou, Nicole S. Wilder, Tera H Skeen, Erin A. Gottlieb, Susan C. Nicolson, Dean B. Andropoulos, and Kristin M. Burns

Subjects
Heart Defects, Congenital, Male, medicine.medical_specialty, law.invention, 03 medical and health sciences, 0302 clinical medicine, Bolus (medicine), Pharmacokinetics, 030202 anesthesiology, law, Cardiopulmonary bypass, medicine, Humans, Hypnotics and Sedatives, Dosing, Dexmedetomidine, Cardiac Surgical Procedures, Infusions, Intravenous, Dose-Response Relationship, Drug, business.industry, Infant, Newborn, Paediatric Anaesthesia, Infant, medicine.disease, Confidence interval, Cardiac surgery, Anesthesiology and Pain Medicine, Anesthesia, Female, business, Junctional rhythm, medicine.drug
Abstract

Background Dexmedetomidine (DEX) is increasingly used intraoperatively in infants undergoing cardiac surgery. This phase 1 multicentre study sought to: (i) determine the safety of DEX for cardiac surgery with cardiopulmonary bypass; (ii) determine the pharmacokinetics (PK) of DEX; (iii) create a PK model and dosing for steady-state DEX plasma levels; and (iv) validate the PK model and dosing. Methods We included 122 neonates and infants (0–180 days) with D-transposition of the great arteries, ventricular septal defect, or tetralogy of Fallot. Dose escalation was used to generate NONMEM® PK modelling, and then validation was performed to achieve low (200–300 pg ml−1), medium (400–500 pg ml−1), and high (600–700 pg ml−1) DEX plasma concentrations. Results Five of 122 subjects had adverse safety outcomes (4.1%; 95% confidence interval [CI], 1.8–9.2%). Two had junctional rhythm, two had second-/third-degree atrioventricular block, and one had hypotension. Clearance (CL) immediately postoperative and CL on CPB were reduced by approximately 50% and 95%, respectively, compared with pre-CPB CL. DEX clearance after CPB was 1240 ml min−1 70 kg−1. Age at 50% maximum clearance was approximately 2 days, and that at 90% maximum clearance was 18 days. Overall, 96.1% of measured DEX concentrations fell within the 5th–95th percentile prediction intervals in the PK model validation. Dosing strategies are recommended for steady-state DEX plasma levels ranging from 200 to 1000 pg ml−1. Conclusions When used with a careful dosing strategy, DEX results in low incidence and severity of adverse safety events in infants undergoing cardiac surgery with cardiopulmonary bypass. This validated PK model should assist clinicians in selecting appropriate dosing. The results of this phase 1 trial provide preliminary data for a phase 3 trial of DEX neuroprotection. Clinical trials registration NCT01915277.

Published
2019

5. Effect of parental origin of damaging variants in pro-angiogenic genes on fetal growth in patients with congenital heart defects: Data and analyses

Author

Hakon Hakonarson, Erin Zullo, Rebecca A. Simmons, Mark W. Russell, Julie S. Moldenhauer, Susan C. Nicolson, J. William Gaynor, Mark P. Johnson, Samuel Parry, Sunkyung Yu, Matthew G. Sampson, Rebecca L. Linn, Jack Rychik, Nancy Burnham, and Michal A. Elovitz

Subjects
Angiogenesis, Fetal growth, Biology, lcsh:Computer applications to medicine. Medical informatics, Congenital cardiac defects, Placental function, 03 medical and health sciences, 0302 clinical medicine, Placenta, Biochemistry, Genetics and Molecular Biology, Genetic variation, medicine, In patient, lcsh:Science (General), Gene, 030304 developmental biology, Genetics, 0303 health sciences, Fetus, Multidisciplinary, medicine.anatomical_structure, embryonic structures, lcsh:R858-859.7, 030217 neurology & neurosurgery, Function (biology), lcsh:Q1-390
Abstract

The placenta is a highly vascular structure composed of both maternal and fetal elements. We have determined that damaging variants in genes responsible for the positive regulation of angiogenesis (PRA) (GO:0045766) that are inherited by the fetus impair fetal growth and placental function in pregnancies involving critical congenital cardiac defects (Russell et al., 2019). In this dataset, we present the specific genetic variants identified, describe the parental origin of each variant where possible and present the analyses regarding the potential effects of parental origin of the variant on placental function and fetal growth. The data presented are related to the research article “Damaging variants in pro-angiogenic genes impair growth in fetuses with cardiac defects” (Russell et al., 2019). Keywords: Genetic variation, Placental function, Fetal growth, Congenital cardiac defects

Published
2019

6. Upper Respiratory Tract Infection

Author

Susan C. Nicolson, Arjunan Ganesh, and James M. Steven

Subjects
Upper respiratory tract infection, business.industry, Immunology, Medicine, business, medicine.disease
Published
2007

7. Contributors

Author

Mark Abel, Gaury S. Adhikary, Maurice S. Albin, Stacey L. Allen, Steven J. Allen, Jonathan M. Anagnostou, Maged Argalious, George A. Arndt, Lori A. Aronson, John L. Atlee, Michael S. Avidan, Isaac Azar, James E. Baker, Narayan Baliga, Shahar Bar-Yosef, Juliana Barr, Curtis L. Baysinger, Eric Bedell, Joan Benca, Patrick E. Benedict, David G. Bjoraker, Susan Black, William S. Blau, Steffan Blumenthal, John C. Boncyk, Alain Borgeat, Lois L. Bready, Thomas P. Broderick, David L. Brown, Adrie Bruijinzeel, Brenda A. Bucklin, Matthew D. Caldwell, William R. Camann, Maria I. Castro, Kevin P. Chan, Mark A. Chaney, Amit V. Chawla, David C.H. Cheng, S. Devi Chiravuri, Gordon Lee Collins, Lois A. Connolly, D. Ryan Cook, Scott D. Cook-Sather, Victoria Coon, John R. Cooper, Charles J. Coté, Douglas B. Coursin, James C. Crews, Deborah A. Davis, Martin L. De Ruyter, Hernando De Soto, Donn M. Dennis, Ronak Desai, Cheryl DeSimone, Cyrus DeSouza, Clifford S. Deutschman, Pema Dorje, Anthony R. Doyle, Kenneth Drasner, Catherine Drexler, Ellen Duncan, Martin W. Dünser, Jörg Dziersk, Michael P. Eaton, Charles E. Edmiston, James B. Eisenkraft, John Ellis, Brenda G. Fahy, Zhuang T. Fang, Doron Feldman, Lynne R. Ferrari, Matthew P. Feuer, Stephanie S.F. Fischer, M. Pamela Fish, Randall Flick, Michael P. Ford, Jennifer T. Fortney, James M.T. Foster, Melissa Franckowiak, Eugene B. Freid, Kimberly Frost-Pineda, Jeffrey L. Galinkin, Arjunan Ganesh, Hind M. Gautam, Rodolfo Gebhardt, Jeremy M. Geiduschek, J.C. Gerancher, Mark S. Gold, Stuart Grant, Glenn P. Gravlee, Ivar Gunnarsson, Mary Ann Gurkowski, Jacob Gutsche, Thomas S. Guyton, Ali Habibi, Saeed Habibi, Charles B. Hantler, H. David Hardman, Barry A. Harrison, Joy L. Hawkins, Christopher M.B. Heard, Stephen O. Heard, James R. Hebl, Robert F. Helfand, Rosemary Hickey, George A. Higgins, Scott Holliday, William Hope, Terese T. Horlocker, Liana Hosu, Kate Huncke, Samuel A. Irefin, William Jacobs, Eric Jacobsohn, J. Michael Jaeger, Michael F.M. James, Gregory M. Janelle, David R. Jobes, Nicola Jones, Shailendra Joshi, Zeev N. Kain, Wendy B. Kang, Shubjeet Kaur, Robert D. Kaye, Paul E. Kazanjian, Jeffrey S. Kelly, Kevin J. Kelly, Robert E. Kettler, Jonathan T. Ketzler, Evan D. Kharasch, M. Sean Kincaid, Kathryn P. King, Kai T. Kiviluoma, Jerome M. Klafta, Pattricia S. Klarr, Sandra L. Kopp, Donald A. Kroll, Kenneth Kuchta, C. Dean Kurth, Arthur M. Lam, Jeffrey L. Lane, Paul B. Langevin, Melissa A. Laxton, Marcia M. Lee, Mijin Lee, Peter J. Lee, Philip Levin, Jerrold H. Levy, Ian Lewis, Ray P. Liao, Spencer S. Liu, Emilio B. Lobato, Robert G. Loeb, Celeste M. Lombardi, Prashant Lotlikar, Michelle L. Lotto, Katarzyna Luba, Stewart J. Lustik, Vinod Malhotra, Christina M. Matadial, Viktoria D. Mayr, Deborah A. McClain, Thomas McCutchen, David L. McDonagh, Susan B. McDonald, Lynda J. Means, Mark Meyer, Mohammed Minhaj, Vivek Moitra, Constance L. Monitto, Terri G. Monk, Lisa M. Montenegro, Timothy E. Morey, Lucille A. Mostello, Isobel Muhiudeen-Russell, J. Thomas Murphy, Catherine Friederich Murray, Michael J. Murray, David Muzic, Nader D. Nader, Carsten Nadjat-Haiem, Mohamed Naguib, Bhiken Naik, David A. Nakata, Charles A. Napolitano, Bradly J. Narr, Krishna M. Natrajan, Norah Naughton, Patrick Neligan, Philippa Newfield, Hector F. Nicodemus, Susan C. Nicolson, Susan H. Noorily, Mark Nunnally, Christopher J. O'Connor, Michael F. O'Connor, Jerome F. O'Hara, Maria A.K. Öhrn, Nollag O'Rourke, Sheela S. Pai, Craig M. Palmer, C. Lee Parmley, Komal Patel, D. Janet Pavlin, Padmavathi Perala, Patricia H. Petrozza, Linda S. Polley, David Porembka, Claudia Praetel, Joseph Previte, Richard C. Prielipp, William Prince, Lester T. Proctor, Donald S. Prough, M. J. Pekka Raatikainen, Lee M. Radke, Sivam Ramanathan, James G. Ramsay, Monica N. Riesner, Edward T. Riley, Pamela R. Roberts, Kerri M. Robertson, Marnie Robinson, John B. Rose, Mark I. Rossberg, David M. Rothenberg, Daniel D. Rubens, Senthilkumar Sadhasivam, Tetsuro Sakai, Francis V. Salinas, Theodore J. Sanford, Ramachandran Satya-Krishna, Scott R. Schulman, Annette Schure, Jeffrey J. Schwartz, Christian Seefelder, Rajamani Sethuraman, Christoph N. Seubert, Jack S. Shanewise, Kelly T. Shannon, Gauhar Sharih, Aarti Sharma, Robert N. Sladen, Peter D. Slinger, Tod B. Sloan, Jonathan H. Slonin, Paul Smythe, Jennifer E. Souders, Scott R. Springman, James M. Steven, Robert K. Stoelting, Mark D. Stoneham, E. Price Stover, Laura Stover, Vijayendra Sudheendra, Kevin J. Sullivan, Christer H. Svensén, James F. Szocik, Kenichi A. Tanaka, Mark D. Tasch, Peter Tassani-Prell, Lisa Thannikary, Klaus D. Torp, Laurence C. Torsher, Mark F. Trankina, Kenneth W. Travis, Lawrence C. Tsen, Avery Tung, Manuel C. Vallejo, Gail A. Van Norman, Karen M. Van Tassel, Gurinder M.S. Vasdev, Melissa M. Vu, Mehernoor F. Watcha, Eileen Watson, B. Craig Weldon, Robert S. Weller, Lynda Wells, Volker Wenzel, Harshdeep Wilkhu, Brian A. Williams, Glyn D. Williams, Lisa Wise-Faberowski, Eric P. Wittkugel, David J. Wlody, Gilbert Y. Wong, Brian J. Woodcock, Christopher C. Young, William L. Young, Christine M. Zainer, Mark A. Zakowski, Paul B. Zanaboni, and R. Victor Zhang

Published
2007

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