Author: "Sullivan, K." / Publisher: elsevier - Searchworks@Jio Institute Digital Library Search Results

181 results on '"Sullivan, K."'

1. Strategies and performance of the CMS silicon tracker alignment during LHC Run 2

Author: Yerevan Physics Institute, Yerevan, Tumasyan Institut für Hochenergiephysik, Armenia A., Vienna, Adam, Austria W., Andrejkovic, J. W., Bergauer, T., Blöch, D., Chatterjee, S., Dragicevic, M., Escalante Del Valle, A., Frühwirth1, R., Hinger, V., Jeitler1, M., Krammer, N., Lechner, L., Liko, D., Mikulec, I., Paulitsch, P., Pitters, F. M., Schieck1, J., Schöfbeck, R., Schwarz, D., Steininger, H., Templ, S., Waltenberger, W., Wulz1 Institute for Nuclear Problems, C. -E., Minsk, Chekhovsky, Belarus V., Litomin, A., Makarenko Universiteit Antwerpen, V., Antwerpen, Beaumont, Belgium W., Darwish2, M. R., De Wolf, E. A., Janssen, T., Kello3, T., Lelek, A., Rejeb Sfar, H., Van Mechelen, P., Van Putte, S., Van Remortel Vrije Universiteit Brussel, N., Brussel, Blekman, Belgium F., Bols, E. S., D’Hondt, J., Delcourt, M., El Faham, H., Lowette, S., Moortgat, S., Morton, A., Muller, D., Sahasransu, A. R., Tavernier, S., Van Doninck, W., Van Mulders Université Libre de Bruxelles, P., Bruxelles, Allard, Belgium Y., Beghin, D., Bilin, B., Clerbaux, B., De Lentdecker, G., Deng, W., Favart, L., Grebenyuk, A., Hohov, D., Kalsi, A. K., Khalilzadeh, A., Lee, K., Mahdavikhorrami, M., Makarenko, I., Moureaux, L., Pétré, L., Popov, A., Postiau, N., Robert, F., Song, Z., Starling, E., Thomas, L., Vanden Bemden, M., Vander Velde, C., Vanlaer, P., Vannerom, D., Wezenbeek, L., Yang Ghent University, Y., Ghent, Cornelis, Belgium T., Dobur, D., Knolle, J., Lambrecht, L., Mestdach, G., Niedziela, M., Roskas, C., Samalan, A., Skovpen, K., Tytgat, M., Ver- massen, B., Vit Université Catholique de Louvain, M., Louvain-la-Neuve, Benecke, Belgium A., Bethani, A., Bruno, G., Bury, F., Caputo, C., David, P., Deblaere, A., Delaere, C., Donertas, I. S., Giammanco, A., Jaffel, K., Jain, Sa., Lemaitre, V., Mondal, K., Prisciandaro, J., Szilasi, N., Taliercio, A., Teklishyn, M., Tran, T. T., Vischia, P., Wertz Centro Brasileiro de Pesquisas Fisicas, S., Rio de Janeiro, Alves, Brazil G. A., Hensel, C., Moraes Universidade do Estado do Rio de Janeiro, A., Aldá Júnior, Brazil W. L., Alves Gallo Pereira, M., Barroso Ferreira Filho, M., Brandao Malbouisson, H., Carvalho, W., Chinellato4, J., Da Costa, E. M., Da Silveira5, G. G., De Jesus Damiao, D., Fonseca De Souza, S., Matos Figueiredo, D., Mora Herrera, C., Mota Amarilo, K., Mundim, L., Nogima, H., Rebello Teles, P., Santoro, A., Silva Do Amaral, S. M., Sznajder, A., Thiel, M., Torres Da Silva De Araujo6, F., Vilela Pereira Universidade Estadual Paulista (a), A., Universidade Federal do ABC (b), São, Paulo, Bernardes5, Brazil C. A., Calligaris, L., Fernandez Perez Tomei, T. R., Gre- gores, E. M., Lemos, D. S., Mercadante, P. G., Novaes, S. F., and Methods in Physics Research, Sandra S. Padula 36 The CMS Collaboration Nuclear Inst., A 1037 (2022) 166795 Institute for Nuclear Research and Nuclear Energy, Bulgarian Academy of Sciences, Sofia, Aleksandrov, Bulgaria A., Antchev, G., Hadjiiska, R., Iaydjiev, P., Misheva, M., Rodozov, M., Shopova, M., Sultanov University of Sofia, G., Dimitrov, Bulgaria A., Ivanov, T., Litov, L., Pavlov, B., Petkov, P., Petrov Beihang University, A., Beijing, Cheng, China T., Javaid7, T., Mittal, M., Wang3, H., Yuan Department of Physics, L., Tsinghua, University, Ahmad, China M., Bauer, G., Dozen8, C., Hu, Z., Martins9, J., Wang, Y., Yi10, K., 11 Institute of High Energy Physics, Chapon, China E., Chen7, G. M., Chen7, H. S., Chen, M., Iemmi, F., Kapoor, A., Leggat, D., Liao, H., Liu7, Z. -A., Milosevic, V., Monti, F., Sharma, R., Tao, J., Thomas-Wilsker, J., Wang, J., Zhang, H., Zhao State Key Laboratory of Nuclear Physics and Technology, J., Peking Uni- versity, Agapitos, China A., An, Y., Ban, Y., Chen, C., Levin, A., Li, Q., Lyu, X., Mao, Y., Qian, S. J., Wang, D., Xiao Sun Yat-Sen University, Q. Wang12 J., Guangzhou, China M., Lu, You Institute of Modern Physics and Key Laboratory of Nuclear Physics and Ion-beam Application (MOE) - Fudan University, Z., Shanghai, Gao3, China X., Okawa Zhejiang University, H., Hangzhou, China, Zhejiang, Lin, China Z., Xiao Universidad de Los Andes, M., Bogota, Avila, Colombia C., Cabrera, A., Florez, C., Fraga Universidad de Antioquia, J., Medellin, Mejia Guisao, Colombia J., Ramirez, F., Ruiz Alvarez, J. D., Salazar González University of Split, C. A., Faculty of Electrical Engineering, Mechanical Engi- neering and Naval Architecture, Split, Giljanovic, Croatia D., Godinovic, N., Lelas, D., Puljak University of Split, I., Faculty of Science, Antunovic, Croatia Z., Kovac, M., Sculac Institute Rudjer Boskovic, T., Zagreb, Brigljevic, Croatia V., Ferencek, D., Majumder, D., Mishra, S., Roguljic, M., Starodumov13, A., Susa University of Cyprus, T., Nicosia, Attikis, Cyprus A., Christoforou, K., Erodotou, E., Ioannou, A., Kole, G., Kolosova, M., Konstantinou, S., Mousa, J., Nicolaou, C., Ptochos, F., Razis, P. A., Rykaczewski, H., Saka Charles University, H., Prague, Finger14, Czech Republic M., M. Finger Jr., 14, Kveton Escuela Politecnica Nacional, A., Quito, Ayala Universidad San Francisco de Quito, Ecuador E., Carrera Jarrin Academy of Scientific Research and Technology of the Arab Republic of Egypt, Ecuador E., Egyptian Network of High Energy Physics, Cairo, Abdalla15, Egypt H., Assran16, Y., 17 Center for High Energy Physics (CHEP-FU), Fayoum, University, El-, Fayoum, Mahmoud, Egypt M. A., Mohammed National Institute of Chemical Physics and Biophysics, Y., Tallinn, Ahmed18, Estonia I., Bhowmik, S., Dewanjee, R. K., Ehataht, K., Kadastik, M., Nandan, S., Nielsen, C., Pata, J., Raidal, M., Tani, L., Veelken Department of Physics, C., University of Helsinki, Helsinki, Eerola, Finland P., Forthomme, L., Kirschenmann, H., Osterberg, K., Vouti- lainen Helsinki Institute of Physics, M., Bharthuar, Finland S., Brücken, E., Garcia, F., Havukainen, J., Kim, M. S., Kinnunen, R., Lampén, T., Lassila-Perini, K., Lehti, S., Lindén, T., Lotti, M., Martikainen, L., Myllymäki, M., Ott, J., Siikonen, H., Tuominen, E., Tuominiemi Lappeenranta University of Technology, J., Lappeenranta, Luukka, Finland P., Petrow, H., Tuuva IRFU, T., Cea, Université, Paris-Saclay, Gif-sur-Yvette, Amendola, France C., Besancon, M., Couderc, F., Dejardin, M., Denegri, D., Faure, J. L., Ferri, F., Ganjour, S., Givernaud, A., Gras, P., Hamel de Monchenault, G., Jarry, P., Lenzi, B., Locci, E., Malcles, J., Rander, J., Rosowsky, A., Sahin, M. Ö., Savoy-Navarro19, A., Titov, M., Yu Laboratoire Leprince-Ringuet, G. B., Cnrs/in2p3, Ecole, Polytechnique, Insti- tut Polytechnique de Paris, Palaiseau, Ahuja, France S., Beaudette, F., Bonanomi, M., Buchot Perraguin, A., Busson, P., Cappati, A., Charlot, C., Davignon, O., Diab, B., Falmagne, G., Ghosh, S., Granier de Cassagnac, R., Hakimi, A., Kucher, I., Motta, J., Nguyen, M., Ochando, C., Paganini, P., Rembser, J., Salerno, R., Sarkar, U., Sauvan, J. B., Sirois, Y., Tarabini, A., Zabi, A., Zghiche Université de Strasbourg, A., Cnrs, IPHC UMR 7178, Strasbourg, Agram20, France J. -L., Andrea, J., Apparu, D., Bloch, D., Bonnin, C., Bourgatte, G., Brom, J. -M., Chabert, E. C., Charles, L., Collard, C., Dangelser, E., Darej, D., Fontaine20, J. -C., Goerlach, U., Grimault, C., Gross, L., Haas, C., Krauth, M., Le Bihan, A. -C., Nibigira, E., Ollivier-henry, N., Silva Jiménez, E., Van Hove Institut de Physique des 2 Infinis de Lyon (IP2I ), P., Villeurbanne, Asilar, France E., Baulieu, G., Beauceron, S., Bernet, C., Boudoul, G., Camen, C., Caponetto, L., Carle, A., Chanon, N., Contardo, D., Dené, P., Depasse, P., Dupasquier, T., El Mamouni, H., Fay, J., Galbit, G., Gascon, S., Gouze- vitch, M., Ille, B., Laktineh, I. B., Lattaud, H., Lesauvage, A., Lethuillier, M., Lumb, N., Mirabito, L., Nodari, B., Perries, S., Shchablo, K., Sordini, V., Torterotot, L., Touquet, G., Vander Donckt, M., Viret Georgian Technical University, S., Tbilisi, Lomidze, Georgia I., Toriashvili21, T., Tsamalaidze14 RWTH Aachen University, Z., Physikalisches Institut, I., Aachen, Autermann, Germany C., Botta, V., Feld, L., Karpinski, W., Kiesel, M. K., Klein, K., Lipinski, M., Louis, D., Meuser, D., Pauls, A., Pierschel, G., Rauch, M. P., Röwert, N., Schomakers, C., Schulz, J., Teroerde, M., Wlochal RWTH Aachen University, M., Physikalisches Institut A, Iii., Dodonova, Ger- many A., Eliseev, D., Erdmann, M., Fackeldey, P., Fischer, B., Hebbeker, T., Hoepfner, K., Ivone, F., Mastrolorenzo, L., and Methods in Physics Research, M. 37 The CMS Collaboration Nuclear Inst., A 1037 (2022) 166795 Merschmeyer, Meyer, A., Mocellin, G., Mondal, S., Mukherjee, S., Noll, D., Novak, A., Pook, T., Pozdnyakov, A., Rath, Y., Reithler, H., Roemer, J., Schmidt, A., Schuler, S. C., Sharma, A., Vigilante, L., Wiedenbeck, S., Zaleski RWTH Aachen University, S., Physikalisches Institut B, Iii., Dziwok, Ger- many C., Flügge, G., Haj Ahmad22, W., Hlushchenko, O., Kress, T., Nowack, A., Pistone, C., Pooth, O., Roy, D., Sert, H., Stahl18, A., Ziemons, T., Zotz Deutsches Elektronen-Synchrotron, A., Hamburg, Aarup Petersen, Germany H., Aldaya Martin, M., Asmuss, P., Baxter, S., Bayat- makou, M., Behnke, O., Bermúdez Martínez, A., Bertsche, D., Bhattacharya, S., Bin Anuar, A. A., Borras23, K., Brunner, D., Campbell, A., Cardini, A., Cheng, C., Colombina, F., Consuegra Rodríguez, S., Correia Silva, G., Danilov, V., De Silva, M., Didukh, L., Domínguez Damiani, D., Eckerlin, G., Eckstein, D., Estevez Banos, L. I., Filatov, O., Gallo24, E., Geiser, A., Giraldi, A., Grados Luyando, J. M., Grohsjean, A., Guthoff, M., Jafari25, A., Jomhari, N. Z., Jung, H., Kasem23, A., Kasemann, M., Kaveh, H., Kleinwort, C., Krücker, D., Lange, W., Lidrych, J., Lipka, K., Lohmann26, W., Mankel, R., Maser, H., Melzer-Pellmann, I. -A., Mendizabal Morentin, M., Metwally, J., Meyer, A. B., Meyer, M., Mittag, G., Mnich, J., Muhl, C., Mussgiller, A., Otarid, Y., Pérez Adán, D., Pitzl, D., Raspereza, A., Reichelt, O., Ribeiro Lopes, B., Rübenach, J., Saggio, A., Saibel, A., Savitskyi, M., Scham27, M., Scheurer, V., Schütze, P., Schwanenberger24, C., Shchedrolosiev, M., Shevchenko, R., Sosa Ricardo, R. E., Stafford, D., Stever, R., Tonon, N., Van De Klundert, M., Velyka, A., Walsh, R., Walter, D., Wen, Y., Wichmann, K., Wiens, L., Wissing, C., Wuchterl, S., Zuber University of Hamburg, A., Aggleton, Germany R., Albrecht, S., Bein, S., Benato, L., Biskop, H., Buhmann, P., Connor, P., De Leo, K., Eich, M., Feindt, F., Fröhlich, A., Garbers, C., Garutti, E., Gunnellini, P., Hajheidari, M., Haller, J., Hinzmann, A., Jabusch, H. R., Kasieczka, G., Klanner, R., Kogler, R., Kramer, T., Kutzner, V., Lange, J., Lange, T., Lobanov, A., Malara, A., Martens, S., Mrowietz, M., Niemeyer, C. E. N., Nigamova, A., Nissan, Y., Pena Rodriguez, K. J., Rieger, O., Schleper, P., Schröder, M., Schwandt, J., Sonneveld, J., Stadie, H., Steinbrück, G., Tews, A., Vormwald, B., Wellhausen, J., Zoi Karlsruher Institut fuer Technologie, I., Karlsruhe, Ardila-Perez, Germany L. E., Balzer, M., Barvich, T., Bechtel, J., Blank, T., Brom- mer, S., Burkart, M., Butz, E., Caselle, M., Caspart, R., Chwalek, T., De Boer†, W., Dierlamm, A., Droll, A., El Morabit, K., Faltermann, N., Giffels, M., Gosewisch, J. o., Gottmann, A., Hartmann18, F., Heidecker, C., Husemann, U., Keicher, P., Koppenhofer, R., Maier, S., Metzler, M., Mitra, S., Müller, Th., Neufeld, M., Neukum, M., Nürnberg, A., Quast, G., Rabbertz, K., Rauser, J., Sander, O., Savoiu, D., Schell, D., Schnepf, M., Seith, D., Shvetsov, I., Simonis, H. J., Stanulla, J., Steck, P., Ulrich, R., Van Der Linden, J., Von Cube, R. F., Wassmer, M., Weber, M., Weddigen, A., Wieland, S., Wittig, F., Wolf, R., Wozniewski, S., Wunsch Institute of Nuclear and Particle Physics (INPP), S., Ncsr, Demokritos, Aghia, Paraskevi, Anagnostou, Greece G., Assiouras, P., Daskalakis, G., Geralis, T., Kazas, I., Kyriakis, A., Loukas, D., Papadopoulos, A., Stakia National and Kapodistrian University of Athens, A., Athens, Diamantopoulou, Greece M., Karasavvas, D., Karathanasis, G., Kontaxakis, P., Koraka, C. K., Manousakis-Katsikakis, A., Panagiotou, A., Papavergou, I., Saoulidou, N., Theofilatos, K., Tziaferi, E., Vellidis, K., Vourliotis National Technical University of Athens, E., Bakas, Greece G., Kousouris, K., Papakrivopoulos, I., Tsipolitis, G., Zacharopoulou, A., Zografos University of Ioánnina, A., Ioánnina, Adamidis, Greece K., Bestintzanos, I., Evangelou, I., Foudas, C., Gianneios, P., Katsoulis, P., Kokkas, P., Manthos, N., Papadopoulos, I., Strologas MTA-ELTE Lendület CMS Particle and Nuclear Physics Group, J., Eötvös Loránd University, Budapest, Csanad, Hungary M., Farkas, K., Gadallah28, M. M. A., Lökös29, S., Major, P., Mandal, K., Mehta, A., Pasztor, G., Rd ́l, A. J., Surányi, O., Veres Wigner Research Centre for Physics, G. I., Balazs, Hungary T., Bartók30, M., Bencze, G., Hajdu, C., Horvath31, D., Márton, K., Sikler, F., Veszpremi Institute of Nuclear Research ATOMKI, V., Debrecen, Czellar, Hungary S., Karancsi30, J., Molnar, J., Szillasi, Z., Teyssier Institute of Physics, D., University of Debrecen, Raics, Hungary P., Trocsanyi32, Z. L., Ujvari Karoly Robert Campus, B., MATE Institute of Technology, Gyongyos, Csorgo33, Hun- gary T., Nemes33, F., Novak Indian Institute of Science (IISc), T., Bangalore, Choudhury, India S., Komaragiri, J. R., Kumar, D., Panwar, L., Tiwari National Institute of Science Education and Research, P. C., Hbni, Bhubaneswar, Bahinipati34, India S., Das, A. K., Kar, C., Mal, P., Mishra, T., Mohanty, R., Muraleedharan Nair Bindhu35, V. K., Nayak35, A., Saha, P., Sur, N., Swain, S. K., Vats35 Punjab University, D., Chandigarh, Bansal, India S., Beri, S. B., Bhatnagar, V., Chaudhary, G., Chauhan, S., Dhingra36, N., Gupta, R., Kaur, A., Kaur, M., Kaur, S., Kumari, P., Meena, M., Sandeep, K., Singh, J. B., Virdi University of Delhi, A. K., Delhi, Ahmed, India A., Bhardwaj, A., Choudhary, B. C., Gola, M., Jain, C., Jain, G., Keshri, S., Kumar, A., Naimuddin, M., Priyanka, P., Ranjan, K., Saumya, S., Shah Saha Institute of Nuclear Physics, A., Hbni, Kolkata, Bharti37, India M., Bhattacharya, R., Bhowmik, D., Dutta, S., Gomber38, B., Maity39, M., Palit, P., Rout, P. K., Saha, G., Sahu, B., Sarkar, S., Sharan, M., Singh37, B., Thakur37 Indian Institute of Technology Madras, S., Madras, Behera, India P. K., Behera, S. C., Kalbhor, P., Muhammad, A., Pradhan, R., Pujahari, P. R., Sikdar Bhabha Atomic Research Centre, A. K., Mumbai, Dutta, India D., Jha, V., Kumar, V., Mishra, D. K., Naskar40, K., Netrakanti, P. K., Pant, L. M., Shukla Tata Institute of Fundamental Research-A, P., Aziz, India T., Dugad, S., Kumar Tata Institute of Fundamental Research-B, M., Banerjee, India S., Chudasama, R., Guchait, M., Karmakar, S., Kumar, S., Majumder, G., Mazumdar, K., Mukherjee Indian Institute of Science Education and Research (IISER), S., Pune, Alpana, India K., Dube, S., Kansal, B., Laha, A., Pandey, S., Rane, A., Rastogi, A., and Methods in Physics Research, S. Sharma 38 The CMS Collaboration Nuclear Inst., A 1037 (2022) 166795 Isfahan University of Technology, Isfahan, Bakhshiansohi12, Iran H., Khazaie, E., Zeinali41 Institute for Research in Fundamental Sciences (IPM), M., Tehran, Abbas, Iran S. M., Chenarani42, S., Etesami, S. M., Khakzad, M., Mohammadi Najafabadi University College Dublin, M., Dublin, Bari, Italy, Bari, Ramos, D., Bologna, Italy, Bologna, Lo Meoa, S., Grosso, G., Lusiani, E., Pavia, Italy, Pavia, Perugia, Italy, Peru-, Gia, Baldinelli, G., Bianchi, F., Magherinib, M., Pisa, Italy, Italy, Albergo, S., Costa, S., Di Mattia, A., Saizu, M. A., Tricomi, A., Tuve, C., Potenza, R., Catania, Italy, Manca, Mandorli, G., Massa, M., Mazzoni, E., Messineo, A., Scrib- anoa, A., Firenze, Italy, Firenze, Frascati, Benussi, Italy L., Bianco, S., Genova, Italy, Gen-, Ova, Milano, Italy, Milano, Boldrini, G., Pinolini, B. S., Napoli, Italy, Potenza, Italy, Padova, Italy, Trento, Beccherle, R., Rome, Italy, Rome, Torino, Italy, Novara, Coli, S., Rivettia, A., Trieste, Italy, Trieste, Daegu, Dogra, Korea S., Huh, C., Kim, B., Kim, D. H., Kim, G. N., Kim, J., Lee, J., Lee, S. W., Moon, C. S., Y. D., Oh, Pak, S. I., Radburn-Smith, B. C., Sekmen, S., Yang Chonnam National University, Y. C., Institute for Universe and Elementary Particles, Kwangju, Kim, Korea H., D’Amantea, V., Di Domenicoa, M. R., D, A 1037 (2022) 166795 Hanyang University, Seoul, Francois, Korea B., Kim, T. J., Park Korea University, J., Cho, Korea S., Choi, S., Go, Y., Hong, B., Lee, K. S., Lim, J., Park, J., Park, S. K., Yoo Kyung Hee University, J., Department of Physics, Republic of Korea, Goh, Korea J., Gurtu Sejong University, A., Kim, Korea H. S., Kim Seoul National University, Y., Almond, Korea J., Bhyun, J. H., Choi, J., Jeon, S., Kim, J. S., Ko, S., Kwon, H., Lee, H., Lee, S., B. H., Oh, Oh, M., S. B., Oh, Seo, H., Yang, U. K., Yoon University of Seoul, I., Jang, Korea W., Kang, D. Y., Kang, Y., Kim, S., Ko, B., Lee, J. S. H., Lee, Y., Park, I. C., Roh, Y., Ryu, M. S., Song, D., Watson, I. J., Yang Yonsei University, S., Korea S., Ha, Yoo Sungkyunkwan University, H. D., Suwon, Choi, Korea M., Yu College of Engineering and Technology, I., American University of the Middle East (AUM), Egaila, Kuwait, Dasman, Beyrouthy, Kuwait T., Maghrbi Riga Technical University, Y., Riga, Veckalns49 Vilnius University, Latvia V., Vilnius, Ambrozas, Lithuania M., Carvalho Antunes De Oliveira, A., Juodagalvis, A., Rinkevicius, A., Tamulaitis National Centre for Particle Physics, G., Universiti, Malaya, Kuala, Lumpur, Bin Norjoharuddeen, Malaysia N., Wan Abdullah, W. A. T., Yusli, M. N., Zolkapli Universidad de Sonora (UNISON), Z., Hermosillo, Benitez, Mexico J. F., Castaneda Hernandez, A., Coello, M. León., Murillo Quijada, J. A., Sehrawat, A., Valencia Palomo Centro de Investigacion y de Estudios Avanzados del IPN, L., Mexico, City, Ayala, Mexico G., Castilla-Valdez, H., De La Cruz-Burelo, E., Heredia-De La Cruz50, I., Lopezfernandez, R., Mondragon Herrera, C. A., Perez Navarro, D. A., Sánchez Hernández Universidad Iberoamericana, A., Carrillo Moreno, Mexico S., Oropeza Barrera, C., Vazquez Valencia Benemerita Universidad Autonoma de Puebla, F., Puebla, Pedraza, Mexico I., Salazar Ibarguen, H. A., Uribe Estrada University of Montenegro, C., Podgorica, Mijuskovic51, Montenegro J., Raicevic University of Auckland, N., Auckland, Krofcheck University of Canterbury, New Zealand D., Christchurch, Butler National Centre for Physics, New Zealand P. H., Quaid-I-Azam, University, Islamabad, Ahmad, Pak- istan A., Asghar, M. I., Awais, A., Awan, M. I. M., Hoorani, H. R., Khan, W. A., Shah, M. A., Shoaib, M., Waqas AGH University of Science and Technology Faculty of Computer Sci- ence, M., Electronics and Telecommunications, Krakow, Avati, Poland V., Grzanka, L., Malawski National Centre for Nuclear Research, M., Swierk, Bialkowska, Poland H., Bluj, M., Boimska, B., Górski, M., Kazana, M., Szleper, M., Zalewski Institute of Experimental Physics, P., Faculty of Physics, University of Warsaw, Warsaw, Bunkowski, Poland K., Doroba, K., Kalinowski, A., Konecki, M., Krolikowski Laboratório de Instrumentção e Física Experimental de Partículas, J., Lisboa, Araujo, Portugal M., Bargassa, P., Bastos, D., Boletti, A., Faccioli, P., Gallinaro, M., Hollar, J., Leonardo, N., Niknejad, T., Pisano, M., Seixas, J., Toldaiev, O., Varela Joint Institute for Nuclear Research, J., Dubna, Afanasiev, Russia S., Budkouski, D., Golutvin, I., Gorbunov, I., Karjavine, V., Korenkov, V., Lanev, A., Malakhov, A., Matveev52, V., Palichik, V., Perelygin, V., Savina, M., Seitova, D., Shalaev, V., Shmatov, S., Shulha, S., Smirnov, V., Teryaev, O., Voytishin, N., Yuldashev54, B. S., Zarubin, A., Zhizhin Petersburg Nuclear Physics Institute, I., Petersburg), Gatchina (St., Gavrilov, Russia G., Golovtcov, V., Ivanov, Y., Kim55, V., Kuznetsova56, E., Murzin, V., Oreshkin, V., Smirnov, I., Sosnov, D., Sulimov, V., Uvarov, L., Volkov, S., Vorobyev Institute for Nuclear Research, A., Moscow, Andreev, Russia Yu., Dermenev, A., Gninenko, S., Golubev, N., Karneyeu, A., Kirpichnikov, D., Kirsanov, M., Krasnikov, N., Pashenkov, A., Pivovarov, G., Alikhanov of NRC ‘Kurchatov Institute’, A. Toropin Institute for Theoretical and Experimental Physics named by A. I., Epshteyn, Russia V., Gavrilov, V., Lychkovskaya, N., Nikitenko57, A., Popov, V., Stepennov, A., Toms, M., Vlasov, E., Zhokin Moscow Institute of Physics and Technology, A., Aushev National Research Nuclear University ’Moscow Engineering Physics Institute’ (MEPhI), Russia T., Bychkova, Russia O., Chadeeva58, M., Parygin, P., Popova, E., Rusinov, V., Lebedev Physical Institute, D. Selivanova P. 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C., Nabili, S., Palmer, C., Seidel, M., Skuja, A., Wang, L., Wong Massachusetts Institute of Technology, K., Cambridge, Massachusetts, Abercrombie, USA D., Andreassi, G., Bi, R., Brandt, S., Busza, W., Cali, I. A., D’Alfonso, M., Eysermans, J., Freer, C., Gomez Ceballos, G., Goncharov, M., Harris, P., Hu, M., Klute, M., Kovalskyi, D., Krupa, J., Lee, Y. -J., Mironov, C., Paus, C., Rankin, D., Roland, C., Roland, G., Shi, Z., Stephans, G. S. F., Wang, Z., Wyslouch University of Minnesota, B., Minneapolis, Minnesota, Chatterjee, USA R. M., Evans, A., Hansen, P., Hiltbrand, J., Jain, Sh., Krohn, M., Kubota, Y., Mans, J., Revering, M., Rusack, R., Saradhy, R., Schroeder, N., Strobbe, N., Wadud University of Mississippi, M. A., Oxford, Mississippi, Acosta, USA J. G., Cremaldi, L. M., Oliveros, S., Perera, L., Summers† University of Nebraska-Lincoln, D., Lincoln, Nebraska, Avdeeva, USA E., Bloom, K., Bryson, M., Claes, D. R., Fangmeier, C., Finco, L., Golf, F., Joo, C., Kravchenko, I., Meier, F., Musich, M., Reed, I., Siado, J. E., Snow†, G. R., Tabb, W., Yan, F., Zecchinelli State University of New York at Buffalo, A. G., Buffalo, Agarwal, USA G., Bandyopadhyay, H., Hay, L., Iashvili, I., Kharchilava, A., Mclean, C., Nguyen, D., Pekkanen, J., Rappoccio, S., Williams Northeastern University, A., Alverson, USA G., Barberis, E., Haddad, Y., Hortiangtham, A., Li, J., Madi- gan, G., Marzocchi, B., Morse, D. M., Nguyen, V., Orimoto, T., Parker, A., Skinnari, L., Tishelman-Charny, A., Wamorkar, T., Wang, B., Wisecarver, A., Wood Northwestern University, D., Evanston, Illinois, Bhattacharya, USA S., Bueghly, J., Chen, Z., Gilbert, A., Gunter, T., Hahn, K. A., Liu, Y., Odell, N., Schmitt, M. H., Sung, K., Velasco University of Notre Dame, M., Notre, Dame, Indiana, Band, USA R., Bucci, R., Das, A., Dev, N., Goldouzian, R., Hildreth, M., Hurtado Anampa, K., Jessop, C., Lannon, K., Lawrence, J., Loukas, N., Lut- ton, D., Marinelli, N., Mcalister, I., Mccauley, T., Mcgrady, C., Mohrman, K., Musienko52, Y., Ruchti, R., Siddireddy, P., Townsend, A., Wayne, M., Wightman, A., Zarucki, M., Zygala The Ohio State University, L., Columbus, Ohio, Bylsma, USA B., Cardwell, B., Durkin, L. S., Francis, B., Hill, C., Nunez Ornelas, M., Wei, K., Winer, B. L., Yates Princeton University, B. R., Princeton, New, Jersey, Addesa, USA F. M., Bonham, B., Das, P., Dezoort, G., Elmer, P., Frankenthal, A., Greenberg, B., Haubrich, N., Higginbotham, S., Kalogeropoulos, A., Kopp, G., Kwan, S., Lange, D., Marlow, D., Mei, K., Ojalvo, I., Olsen, J., Stickland, D., Tully University of Puerto Rico, C., Mayaguez, Puerto, Rico, Malik, USA S., Norberg, S., Ramirez Vargas Purdue University, J. E., West, Lafayette, Bakshi, USA A. S., Barnes, V. E., Chawla, R., Das, S., Gutay, L., Jones, M., Jung, A. W., Karmarkar, S., Kondratyev, D., Koshy, A. M., Liu, M., Negro, G., Neumeister, N., Paspalaki, G., Piperov, S., Purohit, A., Schulte, J. F., Stojanovic19, M., Thieman, J., Wang, F., Xiao, R., Xie Purdue University Northwest, W., Hammond, Indiana, Dolen, USA J., Parashar Rice University, N., Houston, Texas, Baty, USA A., Decaro, M., Dildick, S., Ecklund, K. M., Freed, S., Gardner, P., Geurts, F. J. M., Li, W., Liu, H., Nussbaum, T., Padley, B. P., Redjimi, R., Shi, W., Stahl Leiton, A. G., Yang, S., Zhang, L., Zhang University of Rochester, Y., Rochester, Bodek, USA A., de Barbaro, P., Demina, R., Dulemba, J. L., Fallon, C., Ferbel, T., Galanti, M., Garcia-Bellido, A., Hindrichs, O., Khukhunaishvili, A., Ranken, E., Taus Rutgers, R., The State University of New Jersey, Piscataway, Bartz, USA E., Chiarito, B., Chou, J. P., Gandrakota, A., Gershtein, Y., Halki- adakis, E., Hart, A., Heindl, M., Karacheban26, O., Laflotte, I., Lath, A., Montalvo, R., Nash, K., Osherson, M., Salur, S., Schnetzer, S., Somalwar, S., Stone, R., Thayil, S. A., Thomas, S., Wang University of Tennessee, H., Knoxville, Tennessee, Acharya, USA H., Delannoy, A. G., Fiorendi, S., Spanier Texas A&, S., University, M, College, Station, Texas, Bouhali98, USA O., Dalchenko, M., Delgado, A., Eusebi, R., Gilmore, J., and Methods in Physics Research, T. 43 The CMS Collaboration Nuclear Inst., A 1037 (2022) 166795 Huang, Kamon99, T., Kim, H., Luo, S., Malhotra, S., Mueller, R., Overton, D., Rathjens, D., Safonov Texas Tech University, A., Lubbock, Texas, Akchurin, USA N., Damgov, J., Hegde, V., Kunori, S., Lamichhane, K., Mengke, T., Muthumuni, S., Peltola, T., Volobouev, I., Whitbeck Vanderbilt University, A., Nashville, Tennessee, Appelt, USA E., D’Angelo, P., Greene, S., Gurrola, A., Johns, W., Melo, A., Ni, H., Padeken, K., Romeo, F., Sheldon, P., Tuo, S., Velkovska University of Virginia, J., Charlottesville, Virginia, Arenton, USA M. W., Cox, B., Cummings, G., Hakala, J., Hirosky, R., Joyce, M., Ledovskoy, A., Li, A., Neu, C., Perez Lara, C. E., Tannenwald, B., White, S., Wolfe Wayne State University, E., Detroit, Michigan, Poudyal University of Wisconsin - Madison, USA N., Madison, Wi, Wisconsin, Black, USA K., Bose, T., Caillol, C., Dasu, S., De Bruyn, I., Everaerts, P., Fienga, F., Galloni, C., He, H., Herndon, M., Hervé, A., Hussain, U., Lanaro, A., Loeliger, A., Loveless, R., Madhusudanan Sreekala, J., Mallampalli, A., Mohammadi, A., Pinna, D., Savin, A., Shang, V., Smith, W. H., Teague, D., Trembath-Reichert, S., Vetens 30 Also at Institute of Physics, W., Hungary 31 Also at Institute of Nuclear Research ATOMKI, Hungary 32 Also at MTA-ELTE Lendület CMS Particle and Nuclear Physics Group, Hungary 33 Also at Wigner Research Centre for Physics, Hungary 34 Also at IIT Bhubaneswar, Bhubaneswar, India 35 Also at Institute of Physics, Khalsa College, India 36 Also at G. H. G., Punjab, India 37 Also at Shoolini University, Solan, India 38 Also at University of Hyderabad, Hyderabad, India 39 Also at University of Visva-Bharati, Santiniketan, India 40 Also at Indian Institute of Technology (IIT), India 41 Also at Sharif University of Technology, Iran 42 Also at Department of Physics, University of Science and Technology of Mazandaran, Behshahr, Iran 43 Now at INFN Sezione di Bari, Università di Bari, Politecnico di Bari, Italy 44 Also at Italian National Agency for New Technologies, Energy and Sustainable Economic Development, Italy 45 Also at Centro Siciliano di Fisica Nucleare, e di Struttura Della Materia, Catania, Italy 46 Also at Horia Hulubei National Institute of Physics and Nuclear Engineering (IFIN-HH), Bucharest, Romania 47 Also at Universita di Napoli ‘Federico II’, Napoli, Italy 48 Also at Consiglio Nazionale delle Ricerche, - Istituto Officina dei Materiali, Perugia, Italy 49 Also at Riga Technical University, Latvia 50 Also at Consejo Nacional de Ciencia, y Tecnología, Mexico 51 Also at IRFU, France 52 Also at Institute for Nuclear Research, Russia 53 Now at National Research Nuclear University ‘Moscow Engineering Physics Institute’ (MEPhI), Russia 54 Also at Institute of Nuclear Physics of the Uzbekistan Academy of Sciences, Tashkent, Petersburg Polytechnic University, Uzbekistan 55 Also at St., Petersburg, St., Russia 56 Also at University of Florida, USA 57 Also at Imperial College, Lebedev Physical Institute, United Kingdom 58 Also at P. N., Russia 59 Also at California Institute of Technology, USA 60 Also at INFN Sezione di Padova, Università di Padova, Università di Trento, Trento, Italy, Padova, Italy 61 Also at Budker Institute of Nuclear Physics, Russia 62 Also at Faculty of Physics, University of Belgrade, Serbia 63 Also at Trincomalee Campus, Eastern, University, Sri, Lanka, Nilaveli, Sri Lanka 64 Also at INFN Sezione di Pavia, Università di Pavia, Italy 65 Also at National and Kapodistrian University of Athens, Greece 66 Also at Ecole Polytechnique Fédérale Lausanne, Lausanne, Switzer- land 67 Also at Universität Zürich, Switzerland 68 Also at Stefan Meyer Institute for Subatomic Physics, Austria 69 Also at Laboratoire d’Annecy-le-Vieux de Physique des Particules, IN2P3-CNRS, Annecyle-Vieux, France 70 Also at Şırnak University, Sirnak, Turkey 71 Also at Near East University, Research Center of Experimental Health Science, Turkey 72 Also at Konya Technical University, Konya, Turkey 73 Also at Piri Reis University, Turkey 74 Also at Adiyaman University, Adiyaman, Turkey 75 Also at Ozyegin University, Turkey 76 Also at Izmir Institute of Technology, Izmir, Turkey 77 Also at Necmettin Erbakan University, Turkey 78 Also at Bozok Universitetesi Rektörlügü, Yozgat, Turkey † Deceased, 1 Also at TU Wien, Wien, Austria, 2 Also at Institute of Basic and Applied Sciences, Faculty of Engineering, Arab Academy for Science, Technology and Maritime Transport, Alexandria, Egypt 3 Also 4 Also 5 Also 6 Also 7 Also 8 Also, 9 Also 10 Also at Nanjing Normal University Department of Physics, Nanjing, China 11 Now at The University of Iowa, USA 12 Also at Deutsches Elektronen-Synchrotron, Alikhanov of NRC ‘Kurchatov Institute’, Germany 13 Also at Institute for Theoretical and Experimental Physics named by A. I., Russia 14 Also at Joint Institute for Nuclear Research, Russia 15 Also at Cairo University, Egypt 16 Also at Suez University, Suez, Egypt 17 Now at British University in Egypt, Egypt 18 Also at CERN, Switzerland 19 Also at Purdue University, USA 20 Also at Université de Haute Alsace, Mulhouse, France 21 Also at Tbilisi State University, Georgia 22 Also at Erzincan Binali Yildirim University, Erzincan, Turkey 23 Also at RWTH Aachen University, Germany 24 Also at University of Hamburg, Germany 25 Also at Isfahan University of Technology, Iran 26 Also at Brandenburg University of Technology, Cottbus, Germany 27 Also at Forschungszentrum Julich, Juelich, Germany 28 Also at Physics Department, Assiut, University, Assiut, Egypt 29 Also at Karoly Robert Campus, Hungary at Université Libre de Bruxelles, Belgium at Universidade Estadual de Campinas, Campinas, Brazil at Federal University of Rio Grande do Sul, Porto, Alegre, Brazil at The University of the State of Amazonas, Manaus, Brazil at University of Chinese Academy of Sciences, China at Department of Physics, China at UFMS, Nova, Andradina, and Methods in Physics Research, Brazil 44 The CMS Collaboration Nuclear Inst., A 1037 (2022) 166795 79 Also at Marmara University, Turkey 80 Also at Milli Savunma University, Turkey 81 Also at Kafkas University, Kars, Turkey 82 Also at Istanbul Bilgi University, Turkey 83 Also at Hacettepe University, Turkey 84 Also at Istanbul University, - Cerrahpasa, Turkey 85 Also at Vrije Universiteit Brussel, Belgium 86 Also at School of Physics and Astronomy, University of Southampton, Southampton, United Kingdom 87 Also at Rutherford Appleton Laboratory, United Kingdom 88 Also at IPPP Durham University, Durham, United Kingdom 89 Also at Monash University, Clayton, Australia 90 Also at Universitá di Torino, Torino, Italy 91 Also at Bethel University, Paul, St., Minneapolis, USA 92 Also at Karamanoğlu Mehmetbey University, Karaman, Turkey 93 Also at Ain Shams University, Egypt 94 Also at Bingol University, Bingol, Turkey 95 Also at Georgian Technical University, Georgia 96 Also at Sinop University, Sinop, Turkey 97 Also at Erciyes University, Kayseri, Turkey 98 Also at Texas A, M University at Qatar, Doha, Qatar 99 Also at Kyungpook National University, Daegu, Korea, Universidad de Cantabria, CMS Collaboration, The CMS Collaboration, Department of Physics, Helsinki Institute of Physics, University of Zurich, Belforte, S., Candelise, V., Casarsa, M., Cossutti, F., DA ROLD, A., DELLA RICCA, G., Sorrentino, G., Vazzoler, F., ET AL (the CMS, Collaboration), Tumasyan, A, Adam, W, Andrejkovic, JW, Bergauer, T, Bloch, D, Chatterjee, S, Dragicevic, M, Del Valle, AE, Fruwirth, R, Hinger, V, Jeitler, M, Krammer, N, Lechner, L, Liko, D, Mikulec, I, Paulitsch, P, Pitters, FM, Schieck, J, Schofbeck, R, Schwarz, D, Steininger, H, Templ, S, Waltenberger, W, Wulz, E, Chekhovsky, V, Litomin, A, Makarenko, V, Beaumont, W, Darwish, MR, De Wolf, EA, Janssen, T, Kello, T, Lelek, A, Sfar, HR, Van Mechelen, P, Van Putte, S, Van Remortel, N, Blekman, F, Bols, ES, D'Hondt, J, Delcourt, M, El Faham, H, Lowette, S, Moortgat, S, Morton, A, Muller, D, Sahasransu, AR, Tavernier, S, Van Doninck, W, Van Mulders, P, Allard, Y, Beghin, D, Bilin, B, Clerbaux, B, De Lentdecker, G, Deng, W, Favart, L, Grebenyuk, A, Hohov, D, Kalsi, AK, Khalilzadeh, A, Lee, K, Mahdavikhorrami, M, Makarenko, I, Moureaux, L, Petre, L, Popov, A, Postiau, N, Robert, F, Song, Z, Starling, E, Thomas, L, Vanden Bemden, M, Vander Velde, C, Vanlaer, P, Vannerom, D, Wezenbeek, L, Yang, Y, Cornelis, T, Dobur, D, Knolle, J, Lambrecht, L, Mestdach, G, Niedziela, M, Roskas, C, Samalan, A, Skovpen, K, Tytgat, M, Vermassen, B, Vit, M, Benecke, A, Bethani, A, Bruno, G, Bury, F, Caputo, C, David, P, Deblaere, A, Delaere, C, Donertas, IS, Giammanco, A, Jaffel, K, Jain, S, Lemaitre, V, Mondal, K, Prisciandaro, J, Szilasi, N, Taliercio, A, Teklishyn, M, Tran, TT, Vischia, P, Wertz, S, Alves, GA, Hensel, C, Moraes, A, Alda, WL, Pereira, MAG, Ferreira, MB, Malbouisson, HB, Carvalho, W, Chinellato, J, Da Costa, EM, Da Silveira, GG, Damiao, DD, De Souza, SF, Figueiredo, DM, Herrera, CM, Amarilo, KM, Mundim, L, Nogima, H, Teles, PR, Santoro, A, Do Amaral, SMS, Sznajder, A, Thiel, M, De Araujo, FTD, Pereira, AV, Bernardes, CA, Calligaris, L, Tomei, TRFP, Gregores, EM, Lemos, DS, Mercadante, PG, Novaes, SF, Padula, SS, Aleksandrov, A, Antchev, G, Hadjiiska, R, Iaydjiev, P, Misheva, M, Rodozov, M, Shopova, M, Sultanov, G, Dimitrov, A, Ivanov, T, Litov, L, Pavlov, B, Petkov, P, Petrov, A, Cheng, T, Javaid, T, Mittal, M, Wang, H, Yuan, L, Ahmad, M, Bauer, G, Dozen, C, Hu, Z, Martins, J, Wang, Y, Yi, K, Chapon, E, Chen, GM, Chen, HS, Chen, M, Iemmi, F, Kapoor, A, Leggat, D, Liao, H, Liu, A, Milosevic, V, Monti, F, Sharma, R, Tao, J, Thomas-Wilsker, J, Wang, J, Zhang, H, Zhao, J, Agapitos, A, An, Y, Ban, Y, Chen, C, Levin, A, Li, Q, Lyu, X, Mao, Y, Qian, SJ, Wang, D, Wang, Q, Lu, M, You, Z, Gao, X, Okawa, H, Lin, Z, Xiao, M, Avila, C, Cabrera, A, Florez, C, Fraga, J, Guisao, JM, Ramirez, F, Alvarez, JDR, Gonzalez, CAS, Giljanovic, D, Godinovic, N, Lelas, D, Puljak, I, Antunovic, Z, Kovac, M, Sculac, T, Brigljevic, V, Ferencek, D, Majumder, D, Mishra, S, Roguljic, M, Starodumov, A, Susa, T, Attikis, A, Christoforou, K, Erodotou, E, Ioannou, A, Kole, G, Kolosova, M, Konstantinou, S, Mousa, J, Nicolaou, C, Ptochos, F, Razis, PA, Rykaczewski, H, Saka, H, Finger, M, Kveton, A, Ayala, E, Jarrin, EC, Abdalla, H, Assran, Y, Mahmoud, MA, Mohammed, Y, Ahmed, I, Bhowmik, S, Dewanjee, RK, Ehataht, K, Kadastik, M, Nandan, S, Nielsen, C, Pata, J, Raidal, M, Tani, L, Veelken, C, Eerola, P, Forthomme, L, Kirschenmann, H, Osterberg, K, Voutilainen, M, Bharthuar, S, Brucken, E, Garcia, F, Havukainen, J, Kim, MS, Kinnunen, R, Lampen, T, Lassila-Perini, K, Lehti, S, Linden, T, Lotti, M, Martikainen, L, Myllymaki, M, Ott, J, Siikonen, H, Tuominen, E, Tuominiemi, J, Luukka, P, Petrow, H, Tuuva, T, Amendola, C, Besancon, M, Couderc, F, Dejardin, M, Denegri, D, Faure, JL, Ferri, F, Ganjour, S, Givernaud, A, Gras, P, de Monchenault, GH, Jarry, P, Lenzi, B, Locci, E, Malcles, J, Rander, J, Rosowsky, A, Sahin, MO, Savoy-Navarro, A, Titov, M, Yu, GB, Ahuja, S, Beaudette, F, Bonanomi, M, Perraguin, AB, Busson, P, Cappati, A, Charlot, C, Davignon, O, Diab, B, Falmagne, G, Ghosh, S, de Cassagnac, RG, Hakimi, A, Kucher, I, Motta, J, Nguyen, M, Ochando, C, Paganini, P, Rembser, J, Salerno, R, Sarkar, U, Sauvan, JB, Sirois, Y, Tarabini, A, Zabi, A, Zghiche, A, Agram, L, Andrea, J, Apparu, D, Bonnin, C, Bourgatte, G, Brom, JM, Chabert, EC, Charles, L, Collard, C, Dangelser, E, Darej, D, Fontaine, C, Goerlach, U, Grimault, C, Gross, L, Haas, C, Krauth, M, Le Bihan, AC, Nibigira, E, Ollivier-henry, N, Jimenez, ES, Van Hove, P, Asilar, E, Baulieu, G, Beauceron, S, Bernet, C, Boudoul, G, Camen, C, Caponetto, L, Carle, A, Chanon, N, Contardo, D, Dene, P, Depasse, P, Dupasquier, T, El Mamouni, H, Fay, J, Galbit, G, Gascon, S, Gouzevitch, M, Ille, B, Laktineh, IB, Lattaud, H, Lesauvage, A, Lethuillier, M, Lumb, N, Mirabito, L, Nodari, B, Perries, S, Shchablo, K, Sordini, V, Torterotot, L, Touquet, G, Vander Donckt, M, Viret, S, Lomidze, I, Toriashvili, T, Tsamalaidze, Z, Autermann, C, Botta, V, Feld, L, Karpinski, W, Kiesel, MK, Klein, K, Lipinski, M, Louis, D, Meuser, D, Pauls, A, Pierschel, G, Rauch, MP, Rowert, N, Schomakers, C, Schulz, J, Teroerde, M, Wlochal, M, Dodonova, A, Eliseev, D, Erdmann, M, Fackeldey, P, Fischer, B, Hebbeker, T, Hoepfner, K, Ivone, F, Mastrolorenzo, L, Merschmeyer, M, Meyer, A, Mocellin, G, Mondal, S, Mukherjee, S, Noll, D, Novak, A, Pook, T, Pozdnyakov, A, Rath, Y, Reithler, H, Roemer, J, Schmidt, A, Schuler, SC, Sharma, A, Vigilante, L, Wiedenbeck, S, Zaleski, S, Dziwok, C, Flugge, G, Ahmad, WH, Hlushchenko, O, Kress, T, Nowack, A, Pistone, C, Pooth, O, Roy, D, Sert, H, Stahl, A, Ziemons, T, Zotz, A, Petersen, HA, Martin, MA, Asmuss, P, Baxter, S, Bayatmakou, M, Behnke, O, Martinez, AB, Bertsche, D, Bhattacharya, S, Bin Anuar, AA, Borras, K, Brunner, D, Campbell, A, Cardini, A, Cheng, C, Colombina, F, Rodriguez, SC, Silva, GC, Danilov, V, De Silva, M, Didukh, L, Damiani, DD, Eckerlin, G, Eckstein, D, Banos, LIE, Filatov, O, Gallo, E, Geiser, A, Giraldi, A, Luyando, JMG, Grohsjean, A, Guthoff, M, Jafari, A, Jomhari, NZ, Jung, H, Kasem, A, Kasemann, M, Kaveh, H, Kleinwort, C, Krucker, D, Lange, W, Lidrych, J, Lipka, K, Lohmann, W, Mankel, R, Maser, H, Melzer-Pellmann, IA, Morentin, MM, Metwally, J, Meyer, AB, Meyer, M, Mittag, G, Mnich, J, Muhl, C, Mussgiller, A, Otarid, Y, Adan, DP, Pitzl, D, Raspereza, A, Reichelt, O, Lopes, BR, Rubenach, J, Saggio, A, Saibel, A, Savitskyi, M, Scham, M, Scheurer, V, Schutze, P, Schwanenberger, C, Shchedrolosiev, M, Shevchenko, R, Ricardo, RES, Stafford, D, Stever, R, Tonon, N, Van De Klundert, M, Velyka, A, Walsh, R, Walter, D, Wen, Y, Wichmann, K, Wiens, L, Wissing, C, Wuchterl, S, Zuber, A, Aggleton, R, Albrecht, S, Bein, S, Benato, L, Biskop, H, Buhmann, P, Connor, P, De Leo, K, Eich, M, Feindt, F, Frohlich, A, Garbers, C, Garutti, E, Gunnellini, P, Hajheidari, M, Haller, J, Hinzmann, A, Jabusch, HR, Kasieczka, G, Klanner, R, Kogler, R, Kramer, T, Kutzner, V, Lange, J, Lange, T, Lobanov, A, Malara, A, Martens, S, Mrowietz, M, Niemeyer, CEN, Nigamova, A, Nissan, Y, Rodriguez, KJP, Rieger, O, Schleper, P, Schroder, M, Schwandt, J, Sonneveld, J, Stadie, H, Steinbruck, G, Tews, A, Vormwald, B, Wellhausen, J, Zoi, I, Ardila-Perez, LE, Balzer, M, Barvich, T, Bechtel, J, Blank, T, Brommer, S, Burkart, M, Butz, E, Caselle, M, Caspart, R, Chwalek, T, De Boer, W, Dierlamm, A, Droll, A, El Morabit, K, Faltermann, N, Giffels, M, Gosewisch, JO, Gottmann, A, Hartmann, F, Heidecker, C, Husemann, U, Keicher, P, Koppenhofer, R, Maier, S, Metzler, M, Mitra, S, Muller, T, Neufeld, M, Neukum, M, Nurnberg, A, Quast, G, Rabbertz, K, Rauser, J, Sander, O, Savoiu, D, Schell, D, Schnepf, M, 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S, Monroy, J, Fuentes, YP, Patterson, JR, Quach, D, Reichert, J, Reid, M, Riley, D, Ryd, A, Smolenski, K, Strohman, C, Sun, W, Thom, J, Wittich, P, Zou, R, Albrow, M, Alyari, M, Apollinari, G, Apresyan, A, Apyan, A, Bakshi, A, Bauerdick, LAT, Berry, D, Berryhill, J, Bhat, PC, Burkett, K, Butler, D, Butler, JN, Canepa, A, Cerati, GB, Cheung, HWK, Chlebana, F, Cremonesi, M, Derylo, G, Di Petrillo, KF, Dickinson, J, Elvira, VD, Feng, Y, Freeman, J, Gecse, Z, Ghosh, A, Gingu, C, Gonzalez, H, Gray, L, Green, D, Grunendahl, S, Gutsche, O, Harris, RM, Heller, R, Herwig, TC, Hirschauer, J, Jayatilaka, B, Jindariani, S, Johnson, M, Joshi, U, Klabbers, P, Klijnsma, T, Klima, B, Kwok, KHM, Lammel, S, Lei, CM, Lincoln, D, Lipton, R, Liu, T, Madrid, C, Maeshima, K, Mantilla, C, Mason, D, McBride, P, Merkel, P, Mrenna, S, Nahn, S, Ngadiuba, J, O'Dell, V, Papadimitriou, V, Pedro, K, Pena, C, Prokofyev, O, Ravera, F, Hall, AR, Ristori, L, Sexton-Kennedy, E, Smith, N, Soha, A, Spalding, WJ, Spiegel, L, Stoynev, S, Strait, J, Taylor, L, Tkaczyk, S, Tran, NV, Uplegger, L, Vaandering, EW, Voirin, E, Weber, HA, Acosta, D, Avery, P, Bourilkov, D, Cadamuro, L, Cherepanov, V, Errico, F, Field, RD, Guerrero, D, Joshi, BM, Kim, M, Koenig, E, Konigsberg, J, Korytov, A, Lo, KH, Matchev, K, Menendez, N, Mitselmakher, G, Madhu, AM, Rawal, N, Rosenzweig, D, Rosenzweig, S, Rotter, J, Shi, K, Sturdy, J, Yigitbasi, E, Zuo, X, Adams, T, Askew, A, Habibullah, R, Hagopian, V, Johnson, KF, Khurana, R, Kolberg, T, Martinez, G, Prosper, H, Schiber, C, Viazlo, O, Yohay, R, Zhang, J, Baarmand, MM, Butalla, S, Elkafrawy, T, Hohlmann, M, Verma, RK, Noonan, D, Rahmani, M, Yumiceva, F, Adams, MR, Gonzalez, HB, Cavanaugh, R, Chen, X, Dittmer, S, Evdokimov, A, Evdokimov, O, Gerber, CE, Hangal, DA, Hofman, DJ, Merrit, AH, Mills, C, Oh, G, Roy, T, Rudrabhatla, S, Tonjes, MB, Varelas, N, Viinikainen, J, Wang, X, Wu, Z, Ye, Z, Alhusseini, M, Dilsiz, K, Durgut, S, Gandrajula, RP, Koseyan, OK, Merlo, JP, Mestvirishvili, A, Nachtman, J, Ogul, H, Onel, Y, Penzo, A, Rude, C, Snyder, C, Tiras, E, Amram, O, Blumenfeld, B, Corcodilos, L, Davis, J, De Havenon, V, Eminizer, M, Feingold, J, Gritsan, AV, Kang, L, Kyriacou, S, Maksimovic, P, Martin, C, Roskes, J, Sullivan, K, Swartz, M, Vami, TA, You, C, Abreu, A, Anguiano, J, Barrera, CB, Baringer, P, Bean, A, Bylinkin, A, Flowers, Z, Isidori, T, Khalil, S, King, J, Krintiras, G, Kropivnitskaya, A, Lazarovits, M, Lindsey, C, Marquez, J, Minafra, N, Murray, M, Nickel, M, Rogan, C, Royon, C, Salvatico, R, Sanders, S, Schmitz, E, Smith, C, Takaki, JDT, Warner, Z, Williams, J, Wilson, G, Duric, S, Ivanov, A, Kaadze, K, Kim, D, Maravin, Y, Mitchell, T, Modak, A, Nam, K, Taylor, R, Rebassoo, F, Wright, D, Adams, E, Baden, A, Baron, O, Belloni, A, Eno, SC, Hadley, NJ, Jabeen, S, Kellogg, RG, Koeth, T, Mignerey, AC, Nabili, S, Palmer, C, Seidel, M, Skuja, A, Wang, L, Wong, K, Abercrombie, D, Andreassi, G, Bi, R, Brandt, S, Busza, W, Cali, IA, D'Alfonso, M, Eysermans, J, Freer, C, Ceballos, GG, Goncharov, M, Harris, P, Hu, M, Klute, M, Kovalskyi, D, Krupa, J, Lee, YJ, Mironov, C, Paus, C, Rankin, D, Roland, C, Roland, G, Shi, Z, Stephans, GSF, Wang, Z, Wyslouch, B, Chatterjee, RM, Evans, A, Hansen, P, Hiltbrand, J, Krohn, M, Kubota, Y, Mans, J, Revering, M, Rusack, R, Saradhy, R, Schroeder, N, Strobbe, N, Wadud, MA, Acosta, JG, Cremaldi, LM, Oliveros, S, Perera, L, Summers, D, Avdeeva, E, Bloom, K, Bryson, M, Claes, DR, Fangmeier, C, Finco, L, Golf, F, Joo, C, Kravchenko, I, Meier, F, Musich, M, Reed, I, Siado, JE, Snow, GR, Tabb, W, Yan, F, Zecchinelli, AG, Agarwal, G, Bandyopadhyay, H, Hay, L, Iashvili, I, Kharchilava, A, McLean, C, Nguyen, D, Pekkanen, J, Rappoccio, S, Williams, A, Alverson, G, Barberis, E, Haddad, Y, Hortiangtham, A, Li, J, Madigan, G, Marzocchi, B, Morse, DM, Nguyen, V, Orimoto, T, Parker, A, Skinnari, L, Tishelman-Charny, A, Wamorkar, T, Wang, B, Wisecarver, A, Wood, D, Bueghly, J, Chen, Z, Gilbert, A, Gunter, T, Hahn, KA, Liu, Y, Odell, N, Schmitt, MH, Sung, K, Velasco, M, Band, R, Bucci, R, Das, A, Dev, N, Goldouzian, R, Hildreth, M, Anampa, KH, Jessop, C, Lannon, K, Lawrence, J, Loukas, N, Lutton, D, Marinelli, N, Mcalister, I, McCauley, T, Mcgrady, C, Mohrman, K, Musienko, Y, Ruchti, R, Siddireddy, P, Townsend, A, Wayne, M, Wightman, A, Zarucki, M, Zygala, L, Bylsma, B, Cardwell, B, Durkin, LS, Francis, B, Hill, C, Ornelas, MN, Wei, K, Winer, BL, Yates, BR, Addesa, FM, Bonham, B, Das, P, Dezoort, G, Elmer, P, Frankenthal, A, Greenberg, B, Haubrich, N, Higginbotham, S, Kalogeropoulos, A, Kopp, G, Kwan, S, Lange, D, Marlow, D, Mei, K, Ojalvo, I, Olsen, J, Stickland, D, Tully, C, Norberg, S, Vargas, JER, Bakshi, AS, Barnes, VE, Chawla, R, Das, S, Gutay, L, Jones, M, Jung, AW, Karmarkar, S, Kondratyev, D, Koshy, AM, Liu, M, Negro, G, Neumeister, N, Paspalaki, G, Piperov, S, Purohit, A, Schulte, JF, Stojanovic, M, Thieman, J, Wang, F, Xiao, R, Xie, W, Dolen, J, Parashar, N, Baty, A, Decaro, M, Dildick, S, Ecklund, KM, Freed, S, Gardner, P, Geurts, FJM, Li, W, Liu, H, Nussbaum, T, Padley, BP, Redjimi, R, Shi, W, Leiton, AGS, Zhang, L, Bodek, A, de Barbaro, P, Demina, R, Dulemba, JL, Fallon, C, Ferbel, T, Galanti, M, Garcia-Bellido, A, Hindrichs, O, Khukhunaishvili, A, Ranken, E, Taus, R, Bartz, E, Chiarito, B, Chou, JP, Gandrakota, A, Gershtein, Y, Halkiadakis, E, Hart, A, Heindl, M, Karacheban, O, Laflotte, I, Lath, A, Montalvo, R, Nash, K, Osherson, M, Salur, S, Schnetzer, S, Somalwar, S, Stone, R, Thayil, SA, Thomas, S, Acharya, H, Delannoy, AG, Fiorendi, S, Spanier, S, Bouhali, O, Dalchenko, M, Delgado, A, Eusebi, R, Gilmore, J, Huang, T, Kamon, T, Luo, S, Malhotra, S, Mueller, R, Overton, D, Rathjens, D, Safonov, A, Akchurin, N, Damgov, J, Hegde, V, Kunori, S, Lamichhane, K, Mengke, T, Muthumuni, S, Peltola, T, Volobouev, I, Whitbeck, A, Appelt, E, D'Angelo, P, Greene, S, Gurrola, A, Johns, W, Melo, A, Ni, H, Padeken, K, Romeo, F, Sheldon, P, Tuo, S, Velkovska, J, Arenton, MW, Cox, B, Cummings, G, Hakala, J, Hirosky, R, Joyce, M, Ledovskoy, A, Li, A, Neu, C, Lara, CEP, Tannenwald, B, White, S, Wolfe, E, Poudyal, N, Black, K, Bose, T, Caillol, C, Dasu, S, De Bruyn, I, Everaerts, P, Fienga, F, Galloni, C, He, H, Herndon, M, Herve, A, Hussain, U, Lanaro, A, Loeliger, A, Loveless, R, Sreekala, JM, Mallampalli, A, Mohammadi, A, Pinna, D, Savin, A, Shang, V, Smith, WH, Teague, D, Trembath-Reichert, S, Vetens, W, Damarseçkin, Serdal, Physics, Elementary Particle Physics, Faculty of Sciences and Bioengineering Sciences, Vriendenkring VUB, and Sağır, Sinan
Subjects: Technology, Physics - Instrumentation and Detectors, Physics::Instrumentation and Detectors, Tracker, Legacy reprocessing, measurement methods, tracking detector, alignment, Settore ING-INF/01 - Elettronica, Physics, Particles & Fields, PARTICLE PHYSICS, LARGE HADRON COLLIDER, CMS, High Energy Physics - Experiment, High Energy Physics - Experiment (hep-ex), tracking detector: alignment, Detector, Alignment, MillePede-II, HipPy, VERTEX, High energy physics, Experimental particle physics, LHC, p p: scattering, p p: colliding beams, B: decay, tau: hadronic decay, interaction: gauge, interaction: model, transverse momentum: missing-energy, new physics: search for, mass spectrum: transverse, black hole: quantum, vector boson: mass, W': leptonic decay, sensitivity, leptoquark: coupling, CERN LHC Coll, leptoquark: mass: lower limit, anomaly, channel cross section: upper limit, effective field theory, Higgs, Detectors and Experimental Techniques, Instruments & Instrumentation, physics.ins-det, Instrumentation, detector, alignment, Physics, Instrumentation and Detectors (physics.ins-det), Nuclear & Particles Physics, Physics, Nuclear, Physical Sciences, 0202 Atomic, Molecular, Nuclear, Particle and Plasma Physics, Engineering sciences. Technology, Particle Physics - Experiment, performance, Nuclear and High Energy Physics, 530 Physics, 0299 Other Physical Sciences, FOS: Physical sciences, 10192 Physics Institute, 114 Physical sciences, 0201 Astronomical and Space Sciences, ddc:530, 3106 Nuclear and High Energy Physics, CMS, performance, Nuclear Science & Technology, numerical calculations, Science & Technology, hep-ex, 3105 Instrumentation, silicon, Physics and Astronomy, alignment [tracking detector], semiconductor detector
Abstract: The strategies for and the performance of the CMS silicon tracking system alignment during the 2015-2018 data-taking period of the LHC are described. The alignment procedures during and after data taking are explained. Alignment scenarios are also derived for use in the simulation of the detector response. Systematic effects, related to intrinsic symmetries of the alignment task or to external constraints, are discussed and illustrated for different scenarios., Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 1037, ISSN:0168-9002, ISSN:1872-9576
Published: 2022
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2. Couple Therapy

Author: Stephenson, K.R., primary, Sullivan, K., additional, and Christensen, A., additional
Published: 2016
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3. Methodology for the development of a national Dental Practice-Based Research Network survey on dentist’s beliefs and behaviors concerning antibiotic prophylaxis

Author: Mougeot, J.-L., Davis, J., Zhao, J., Sullivan, K., Thornhill, M., McKnight, P., Stephens, C., Lockhart, P., and The National Dental PBRN Collaborative Group
Abstract: Background\ud Dentists are high prescribers of antibiotics for both treatment and prevention of infection, although there are few guidelines to aid clinicians. Given the worldwide concerns about unnecessary use of antibiotics, there is a need for a better understanding of dentists’ use of these drugs for antibiotic prophylaxis (AP) to prevent distant site infections (i.e., infective endocarditis and prosthetic joint infection).\ud \ud Objective\ud The aim of this study was to develop and implement an effective, self-reporting, cross-sectional, survey instrument that optimized the response rate and maximized reliability and validity for determining the beliefs and behaviors of a large and nationally representative group of generalist and specialist dentists concerning their use of AP.\ud \ud Study Design\ud A 15-question survey (58 items) was developed in a structured process by a multidisciplinary team and configured for automated online dissemination to 3584 national Dental Practice-Based Research Network (DPBRN; hitherto referred to as “Network”) practitioners. The implementation phase consisted of 3 waves of greater than 1000 Network members. Additionally, 47 randomly selected dentists were surveyed twice to assess test–retest reliability.\ud \ud Results\ud Of 3584 eligible Network members, 2169 (60.5%) completed the survey. The age and geographic distributions of responders was similar to those of dentists in the 2019 American Dental Association census. Furthermore, test–retest weighted kappa values for the survey were acceptable (median 0.56; interquartile range 0.42–0.64).\ud \ud Conclusions\ud We developed a highly structured survey with a high response rate and good reliability that will allow us to obtain unique data on dentists’ beliefs and practices regarding AP prescribing.
Published: 2020

4. The Purpose of Storytelling: Analyzing Dag and The Dinosaur

Author: SULLIVAN, K, primary
Published: 2007
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5. Storyboarding: An Interview with Nathan Greno, Walt Disney Feature Animation

Author: SULLIVAN, K, primary
Published: 2007
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6. The Ideas behind Gopher Broke: An Interview with Jeff Fowler, Blur Studios

Author: SULLIVAN, K, primary
Published: 2007
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7. Building Better Content

Author: SULLIVAN, K, primary
Published: 2007
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8. Acting: Exploring the Human Condition

Author: SULLIVAN, K, primary
Published: 2007
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9. Building Story

Author: SULLIVAN, K, primary
Published: 2007
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10. Staging

Author: SULLIVAN, K, primary
Published: 2007
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11. Building Character and Location

Author: SULLIVAN, K, primary
Published: 2007
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12. The Purpose of Dialogue

Author: SULLIVAN, K, primary
Published: 2007
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13. Personality, Goals, Shapes, and Variance in Character Design: Tom Bancroft, Funnypages Productions, LLC

Author: SULLIVAN, K, primary
Published: 2007
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14. Story Background and Theory

Author: SULLIVAN, K, primary
Published: 2007
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15. Pitching Stories: Sande Scoredos, Sony Pictures Imageworks

Author: SULLIVAN, K, primary
Published: 2007
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16. Making the Animated Short: An Interview with Andrew Jimenez, Pixar Animation Studios

Author: SULLIVAN, K, primary
Published: 2007
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17. Visual Design: Interviews with Kendal Cronkhite and Kathy Altieri, DreamWorks Feature Animation

Author: SULLIVAN, K, primary
Published: 2007
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18. Story and Humor: An Interview with Chris Renaud and Mike Thurmeier, Blue Sky Animation Studios

Author: SULLIVAN, K, primary
Published: 2007
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19. Using industrial ecology and strategic management concepts to pursue the Sustainable Development Goals

Author: Sullivan, K., Thomas, S., Rosano, Michele, Sullivan, K., Thomas, S., and Rosano, Michele
Abstract: The subjectivity, complexity, and often competing interests of sustainable development have limited the effectiveness of integrating these important ideas into mainstream business strategy. With the adoption of the UN Sustainable Development Goals (SDGs) in January 2016, there are now global sustainability benchmarks that apply across diverse sectors and national contexts, allowing public and private organizations to orient and evaluate their activities, strategies, and business outcomes. However, it is not directly apparent where the advantage for business lies in pursuit of these actions within the prevailing economic paradigm, highlighting the need for new analytical frameworks and tools. Industrial ecology (IE) has been successfully used in engineering practice for decades and has been suggested as a method that can provide the concepts and methods necessary to bridge the gap between traditional busine ss practice and sustainable development. To test this, literature bridging the fields of industrial ecology, business strategy, and sustainable development was collected and analyzed using the textual analysis software Leximancer™. The analysis showed that while the SDGs are primarily aimed at the national level, they also hold relevance for business through innovation, partnerships, and strategic positioning, inter alia. The analysis found that the integration of IE and business strategy is highly relevant for three of the SDGs, but captures elements of all 17 to varying degrees. IE has a strong focus on innovation and its potential in new markets, products, and business models. IE is also consciously aimed at the efficient use of energy and resources, ideas that are relevant to mitigating, adapting, and building resilience in a changing future, but are also relevant to traditional concepts of business strategy and competitive advantage. This paper shows that through the combination of IE and strategic management theory, commercial organizations can positively co
Published: 2018

20. Associations Between Social Media Use and Anxiety Among Adolescents: A Systematic Review Study.

Author: Kerr B, Garimella A, Pillarisetti L, Charlly N, Sullivan K, and Moreno MA
Abstract: Purpose: Studies show mixed associations between adolescent social media use and anxiety. This systematic review evaluated research on social media and anxiety among adolescents for direction of associations, social media measures, demographic stratification, anxiety measures, and study quality., Methods: We searched for articles published in English before 2021 that tested associations between adolescent social media use and anxiety. Each study underwent screening and data extraction by two reviewers. Measures included direction of associations (positive, negative, null, mixed), social media measures, demographic group stratification, anxiety measures, and study quality (Strengthening of Reporting of Observational Studies in Epidemiology)., Results: A total of 32 studies were included. Over half reported positive associations between social media use and anxiety (56.3%). Problematic use was the most common social media measure type (31.4%). Positive associations with anxiety were predominantly observed for measures of problematic use (75.0%) and screen time (72.7%). Among other social media measures, 40.9% showed positive associations. A total of 18 anxiety measures were used. Four studies (12.5%) stratified findings by gender identity. The mean Strengthening of Reporting of Observational Studies in Epidemiology score was 34.1 (standard deviation = 4.3) out of 46., Discussion: Future work should explore accurate social media use measures that are not based on problematic use., (Published by Elsevier Inc.)
Published: 2024
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21. Development and Evaluation of a Metric-based Clinical Simulation Procedure for Assessing Ostomy Care in Nursing Practice.

Author: Haughey M, Harman M, Hopkins C, Watson A, Goodwin C, Hines J, Sullivan K, Gonzaga C, Washburn A, and Neyens DM
Abstract: Background: There is a need to understand the clinical decision-making and work practices within ostomy nursing care to support expanding nursing training., Objective: To develop and evaluate a new metric-based simulation for assessing ostomy nursing care using a human factors approach., Sample: This pilot study involved eleven stakeholders in the needs assessment, six nurse participants performing simulated ostomy care, and three independent observers assessing procedure reliability., Method: We conducted a needs assessment of ostomy nursing care and training, developed an enhanced metric-based simulation for ostomy appliance change procedures, and statistically evaluated its reliability for measuring the simulated tasks., Results: The enhanced metric-based simulation captured different tasks within four task categories: product selection; stoma and peristomal skin care; baseplate sizing and adhesion; and infection control strategies. The video review procedure was reliable for assessing continuous (average ICC≥0.96) and categorical (average κ>0.96) variables., Conclusion: The new metric-based simulation was suitable for characterizing a broad range of clinical decision-making and work practices in ostomy nursing care.
Published: 2024
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22. Unprofessionalism in anesthesiology: A qualitative study on classifying unprofessional behavior in anesthesiology residency education.

Author: Chen F, Belgique ST, Canter C, Boscardin CK, Willie C, Mitchell JD, Sullivan K, and Martinelli SM
Subjects: Humans, Professional Misconduct statistics & numerical data, Male, Female, Education, Medical, Graduate, Professionalism, United States, Anesthesiology education, Internship and Residency, Qualitative Research, Faculty, Medical psychology, Faculty, Medical statistics & numerical data
Abstract: Study Objective: This study aims to identify the domains that constitute behaviors perceived to be unprofessional in anesthesiology residency training programs., Design: Qualitative study., Setting: Anesthesiology residency training programs., Patients: Not applicable. The participants involved residents, fellows, and faculty members purposefully sampled in four US-based anesthesiology residency programs., Interventions: Participants were asked to submit examples of unprofessional behavior they witnessed in anesthesiology residents, fellows, or faculty members via a Qualtrics link., Measurements: Not applicable. The behavior examples were independently reviewed and categorized into themes using content analysis., Main Results: A total of 116 vignettes were collected, resulting in a final list of 111 vignettes after excluding those that did not describe behavior exhibited by anesthesiology faculty or trainees. Fifty-eight vignettes pertained to unprofessional behaviors observed in faculty members and 53 were observed in trainees (residents and fellows). Nine unprofessionalism themes emerged in the analysis. The most common themes were VERBAL, SUPERVISION, QUALITY, ENGAGEMENT, and TIME. As to the distribution of role group (faculty versus trainee) by theme, unprofessional behaviors falling into the categories of BIAS, GOSSIP, LEWD, and VERBAL were observed more in faculty; whereas themes with unprofessional behavior primarily attributed to trainees included ENGAGEMENT, QUALITY, TIME, and SUPERVISION., Conclusion: By reviewing reported professionalism-related vignettes within residency training programs, we identified classification descriptors for defining unprofessional behavior specific to anesthesiology residency education. Findings from this study enrich the definition of professionalism as a multi-dimensional competency pertaining to anesthesiology graduate medical education. This framework may facilitate preventative intervention and timely remediation plans for unprofessional behavior in residents and faculty., Competing Interests: Declaration of competing interest The authors declare no competing interests., (Copyright © 2024 Elsevier Inc. All rights reserved.)
Published: 2024
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23. Transapical balloon dilation of cor triatriatum sinister in a cat.

Author: Karlin E, Rush J, McCarthy R, Alartosky A, Reader R, Sullivan K, LaMastro J, and Melhorn H
Subjects: Animals, Male, Cats, Echocardiography, Transesophageal veterinary, Cor Triatriatum veterinary, Cor Triatriatum surgery, Cat Diseases surgery, Cat Diseases diagnostic imaging, Cat Diseases therapy
Abstract: A hybrid surgical approach was utilized to address cor triatriatum sinister in a 10-month-old castrated male domestic shorthair cat. Prior to surgery, open-mouth breathing occurred with exertion. The procedure was guided by transesophageal echocardiography and fluoroscopy. A minithoracotomy was performed, and the left atrial membrane was accessed via an introducer placed through the left ventricular apex. Sequential balloon dilations were performed, and the mean transmembrane gradient under anesthesia was reduced from 16 mmHg to 2.23 mmHg. Four months after surgery, the transmembrane mean gradient remained lower than prior to intervention. The cat tolerated surgery well and remains free of clinical signs nine months after surgery., (Copyright © 2024 Elsevier B.V. All rights reserved.)
Published: 2024
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24. Quantification of quaternary ammonium compounds by liquid chromatography-mass spectrometry: Minimizing losses from the field to the laboratory.

Author: Monteil-Rivera F, Locke S, Ye M, Smyth SA, Sullivan K, Okonski A, Jagla M, and Gutzman D
Subjects: Chromatography, Liquid methods, Limit of Detection, Water Pollutants, Chemical analysis, Liquid Chromatography-Mass Spectrometry, Quaternary Ammonium Compounds chemistry, Tandem Mass Spectrometry methods, Solid Phase Extraction methods
Abstract: Quaternary Ammonium Compounds (QACs) are widely used in household, medical and industrial settings. As a consequence, they are ubiquitously found in the environment. Although significant efforts have been put into the development of sensitive and reproducible analytical methods, much less effort has been dedicated to the monitoring of QACs upon sample storage and sample preparation. Here we studied the effect of storage, concentration, and extraction procedures on the concentrations of QACs in samples. Thirteen QACs selected amongst benzalkonium compounds (BACs), dialkyldimethylammonium compounds (DADMACs) and alkyltrimethylammonium compounds (ATMACs) were quantified in aqueous and solid samples using LC-MS/MS. Most QACs adsorbed on container walls could be recovered using a short washing step with MeOH containing 2 % v/v formic acid. Concentrations of QACs from aqueous solutions using solid phase extraction (SPE) with Strata-X cartridges and elution with acidified MeOH utilized to wash the emptied containers gave highly satisfactory recoveries (101-111 %). Good recoveries (89-116 %) were also obtained when extracting a spiked organic-rich synthetic soil using accelerated solvent extraction (ASE) with acidified MeOH at low solid/solvent ratio (0.4 g/20 mL). Applying the recommended methodologies to real samples collected from a Canadian wastewater treatment plant (WWTP) gave QAC concentrations in the ranges of 0.01-30 µg/L, < 1.2 µg/L, and 0.05-27 mg/kg for the influent, effluent and biosolids samples, respectively., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024. Published by Elsevier B.V.)
Published: 2024
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25. Contrasting copper concentrations and isotopic compositions in two Great Lakes watersheds.

Author: Junqueira TP, Araújo DF, Harrison AL, Sullivan K, Leybourne MI, and Vriens B
Abstract: Copper (Cu) stable isotopes can elucidate the biogeochemical controls and sources governing Cu dynamics in aquatic environments, but their application in larger rivers and catchments remains comparatively scarce. Here, we use major and trace element hydrogeochemical data, Cu isotope analyses, and mixing modeling, to assess Cu loads and sources in two major river systems in Ontario, Canada. In both the Spanish River and Trent River catchments, aqueous hydrochemical compositions appeared reasonably consistent, but Cu concentrations were more variable spatially. In the Spanish River, waters near (historic) industrial mining activities displayed positive Cu isotope compositions (δ 65 Cu SRM-976 between +0.75 ‰ and +1.01 ‰), but these signatures were gradually attenuated downstream by mixing with natural background waters (δ 65 Cu -0.65 ‰ to -0.16 ‰). In contrast, Trent River waters exhibited more irregular in-stream Cu isotope patterns (δ 65 Cu from -0.75 ‰ to +0.21 ‰), beyond the variability in Cu isotope signatures observed for adjacent agricultural soils (δ 65 Cu between -0.26 ‰ and +0.30 ‰) and lacking spatial correlation, reflective of the more diffuse sourcing and entwined endmember contributions to Cu loads in this catchment. This work shows that metal stable isotopes may improve our understanding of the sources and baseline dynamics of metals, even in large river systems., Competing Interests: Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Bas Vriens reports financial support was provided by National Science and Engineering Research Council (NSERC) Canada., (Copyright © 2023 The Authors. Published by Elsevier B.V. All rights reserved.)
Published: 2023
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26. Defining entrustable professional activities for first year anesthesiology residents: A Delphi study.

Author: Tanaka P, Marty A, Park YS, Kakazu C, Udani A, Pardo M, Sullivan K, Sandhu C, Turner J, Mitchell J, and Macario A
Subjects: Humans, United States, Delphi Technique, Competency-Based Education, Curriculum, Clinical Competence, Anesthesiology, Internship and Residency
Abstract: Introduction: The use of entrustable professional activities (EPAs) as a basis for assessment may bridge the gap between the theory of competency-based education and clinical practice. The purpose of this study was to develop and validate EPAs for United States (US) first-year clinical anesthesia (CA-1) residents for anesthesiology residency programs to use as the basis for curriculum development and workplace assessment., Methods: From a list of EPAs abstracted from the literature, an expert panel through a modified Delphi consensus process established EPAs for the CA1 curriculum., Results: The final list of EPAs after group consensus had 28 EPAs, with 14 (50%) considered to be applicable to the CA-1 year. An 80% consensus rate was used to accept or reject the final list., Conclusion: This study applied a construct validity lens to EPA development providing assurance that the EPAs adopted are appropriate for use in workplace-based assessment and entrustment decision-making., Competing Interests: Declaration of Competing Interest None., (Copyright © 2023. Published by Elsevier Inc.)
Published: 2023
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27. A Novel Web-Based and Mobile Application to Measure Real-Time Moral Distress: An Initial Pilot and Feasibility Study.

Author: Amos V, Phair N, Sullivan K, Wocial LD, and Epstein B
Subjects: Humans, Feasibility Studies, Reproducibility of Results, Morals, Internet, Mobile Applications
Abstract: Problem Definition: Moral distress (MoD) is a vital clinical indicator linked to clinician burnout and provider concerns about declining patient care quality. Yet it is not routinely assessed. Earlier, real-time recognition may better target interventions aimed at alleviating MoD and thereby increase provider well-being and improve patient care quality., Initial Approach and Testing: Combining two validated MoD instruments (the Moral Distress Thermometer [MDT] and the Measure of Moral Distress for Healthcare Professionals [MMD-HP]), the authors developed a novel mobile and Web-based application environment to measure and report levels MoD and their associated causes. This app was tested for basic feasibility and acceptability in two groups: graduate nursing students and practicing critical care nurses., Results: The MDT app appears feasible and acceptable for future use. All participants (n = 34) indicated the MDT app was satisfying to use, and 91.2% (n = 31) indicated the app was "very appropriate" for measuring MoD. In addition, 84.2% (n =16) of practicing nurses indicated the app fit either "somewhat well" (47.4%, n = 9) or "very well" (36.8%, n = 7) into their typical workday, and 68.4% (n = 13) said they were either "extremely likely" or "somewhat likely" to use the app daily in clinical practice., Key Insights and Next Steps: Education about moral distress and its associated causes proved important to the MDT app's success. It is ready for future validity and reliability testing, as well as examining usability beyond nursing, longitudinal data monitoring, and possible leveraging to pre- and postintervention evaluation studies., (Copyright © 2023 The Joint Commission. Published by Elsevier Inc. All rights reserved.)
Published: 2023
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28. Animal use and opportunities for reduction in carcinogenicity studies supporting approved new drug applications in the U.S., 2015-2019.

Author: Manuppello J, Slankster-Schmierer E, Baker E, and Sullivan K
Subjects: United States, Rats, Mice, Animals, Mice, Transgenic, United States Food and Drug Administration, Toxicokinetics, Carcinogenicity Tests
Abstract: A minimum of 65,341 rats and mice were used in 109 carcinogenicity studies conducted for new drug applications approved by the U.S. Food and Drug Administration from 2015 through 2019. By analyzing how these animals were used, we compared the potential for reducing animal use of implementing existing international guidelines and recommendations. The greatest reduction, 18.7%, would result from evaluating exposure by microsampling blood in main studies to replace toxicokinetics satellites, which used three-fold more mice than rats. A similar reduction, 17.3%, would result from replacing 33 long-term studies in mice with short-term studies in transgenic mice. Based on histopathology findings in chronic studies, 15 long-term studies in rats could have been waived, using 8410 fewer rats. Simply using single, rather than dual, negative control groups would result in a 7.8% reduction, and eliminating positive control groups would use 640 fewer transgenic mice. Combined, an estimated 46% reduction would be achieved, using approximately 29,876 fewer animals. The publication of an addendum to the main carcinogenicity testing guideline promises to decrease the number of long-term studies conducted in rats and mice and presents opportunity to promote full harmonization and implementation of related recommendations that would further dramatically reduce animal use., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.)
Published: 2023
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29. The association between non-English primary language and COVID-19 clinical trial eligibility and enrollment: A retrospective cohort study.

Author: Tait SD, Sacks CA, Dougan M, Sullivan K, Tsai AC, McCoy TH, and North CM
Subjects: Humans, Retrospective Studies, Eligibility Determination, Logistic Models, Language, COVID-19 epidemiology, COVID-19 therapy
Abstract: Background: Establishing equitable access to COVID-19 clinical trials is an important step in mitigating outcomes disparities. Historically, language has served as a barrier to equitable clinical trial participation., Methods: A centralized research infrastructure was established at our institution to screen potential trial participants and to promote efficient and equitable access to COVID-19 clinical trials. Rates of eligibility and enrollment in COVID-19 clinical trials by primary language between April 9 and July 31, 2020 (during the first regional COVID-19 surge) were evaluated using logistic regression. Estimates were adjusted for potential confounders including age, sex, and time., Results: A total of 1245 patients were admitted to the hospital with COVID-19 during the study period and screened for clinical trial eligibility. Among all screened patients, 487 (39%) had a non-English primary language. After adjustment, patients with a non-English primary language had 1.98 times higher odds (CI 1.51 to 2.59) of being eligible for 1 or more COVID-19 clinical trials. Among eligible patients, those with a non-English primary language had 1.83 times higher odds (CI 1.36 to 2.47) of enrolling in COVID-19 clinical trials than patients with English as the primary language., Conculsion: These findings suggest that there are modifiable barriers that can be addressed to lessen the impact of language discordance on access to clinical trials and provide an opportunity to further investigate factors associated with clinical trial participation for patients whose primary language is not English., Competing Interests: Declaration of Competing Interest ACT reports receiving a financial honorarium from Elsevier, Inc. for his work as Co-Editor-in-Chief of the journal SSM-Mental Health. CMN receives consulting fees from Axle Informatics. THM reports receiving a financial honorarium from Springer Nature. MD has research funding from Novartis and Eli Lilly; he has received consulting fees from Tillotts Pharma, ORIC Pharmaceuticals, Partner Therapeutics, SQZ Biotech, AzurRx, Eli Lilly, Mallinckrodt Pharmaceuticals, Aditum, and Moderna; he has received honoraria from UpToDate, Sandoz Academy, Experts at Your Fingertips, and WebMD; and he is a member of the Scientific Advisory Board for Neoleukin Therapeutics., (Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.)
Published: 2022
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30. Preliminary analysis of coronavirus disease 2019 variable insertion into Vascular Quality Initiative registries.

Author: Sullivan K, Mureebe L, Huffman K, Eldrup-Jorgensen J, and Lemmon GW
Subjects: Humans, Registries, Retrospective Studies, Treatment Outcome, Risk Factors, Quality Improvement, COVID-19, Peripheral Arterial Disease
Published: 2022
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31. Interpretation and reporting of mixed DNA profiles by seven forensic laboratories in the UK and Ireland.

Author: Mallinder B, Pope S, Thomson J, Beck LA, McDonald A, Ramsbottom D, Court DS, Vanhinsbergh D, Barber M, Evett I, Sullivan K, and Whitaker J
Subjects: DNA genetics, Humans, Ireland, Microsatellite Repeats, United Kingdom, DNA Fingerprinting methods, Laboratories
Abstract: In 2014, the UK Forensic Science Regulator (FSR) commissioned a collaborative trial to assess the methods used by forensic service providers (FSPs) in the UK and Ireland for analysis, interpretation and reporting of mixed DNA profiles. Five different mixed samples of varying complexity with supporting mock case circumstances were tested using SGMPlus™ and the newly introduced DNA-17(+) multiplexes and reported by participating laboratories. The results demonstrated a high degree of consistency in analytical methods and allele designations, but some variation in the statistical evaluation and reporting of results. Some of the differences noted were attributable to the major technology change to 17(+)-STR systems which had recently been implemented across the UK at that time. The FSR made recommendations based on the trial outcomes which were intended to produce a more consistent approach to mixtures analysis, interpretation and reporting. Four years later, the Association of Forensic Science Providers (AFSP) repeated the trial, with all major UK and Ireland FSPs (both public sector and private companies) again participating. This second trial used the same mixture set as the 2014 trial but was focussed on the methods for interpretation and evaluation. Since 2014, all UK and Ireland FSPs have implemented probabilistic statistical software using continuous models enabling statistical evaluation of more complex mixtures than was possible in 2014. The trial was therefore aimed at investigating the value of these improved capabilities and also to investigate if there appeared to be marked differences between the different software tools in use in the UK. The results demonstrate a high degree of concordance within and between FSPs and across different evaluation models, and will provide important support for the use of such models in evaluation of mixed DNA profiles., (Copyright © 2022 Elsevier B.V. All rights reserved.)
Published: 2022
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32. Effect of implementation of a 12-dose once-weekly treatment (3HP) in addition to standard regimens to prevent TB on completion rates: Interrupted time series design.

Author: Alvarez GG, Sullivan K, Pease C, Van Dyk D, Mallick R, Taljaard M, Grimshaw JM, Amaratunga K, Allen C, Brethour K, Mulpuru S, Pakhale S, Aaron SD, Cameron DW, Alsdurf H, Hui C, and Zwerling AA
Subjects: Adult, Drug Therapy, Combination, Humans, Interrupted Time Series Analysis, Isoniazid therapeutic use, Rifampin therapeutic use, Antitubercular Agents therapeutic use, Latent Tuberculosis drug therapy
Abstract: Objectives: We aimed to determine if offering a 12-dose once-weekly treatment (3HP) as an additional treatment option would result in an increase in the overall proportion of patients completing TB preventive treatment (TPT) above the baseline rate., Methods: We analyzed outcomes in consecutive adults referred to a TB clinic from January 2010 to May 2019. Starting December 2016, 3HP was offered as an alternative to standard clinic regimens which included 9 months of daily isoniazid or 4 months of daily rifampin. The primary outcome was the proportion of patients who completed TPT among all patients who started treatment. Using segmented autoregression analysis, we compared completion at the end of the study with projected completion had the intervention not been introduced., Results: A total of 2803 adults were referred for assessment over the study period. There was an absolute increase in completions among those who started a treatment of 19.0% at the end of the study between the observed intervention completion rate and the projected completion rate from the baseline study period (the completion rate had the 3HP intervention not been introduced) (76% observed vs 57% projected; 95% CI 6.6 to 31.4%; p = 0.004) and an absolute increase among those who were offered treatment (17.3%; 95% CI, 2.3 to 32.3%; p = 0.025)., Conclusions: The introduction of 3HP for TPT as an alternative to the regular regimens offered resulted in a significant increase in the proportion of patients completing treatment. Our study provides evidence to support accelerated use of 3HP in Canada., (Copyright © 2022 The Author(s). Published by Elsevier Ltd.. All rights reserved.)
Published: 2022
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33. Hydrogeochemical mineral exploration in deeply weathered terrains: An example from Mumbwa, Zambia.

Author: Kidder JA, Sullivan K, Leybourne MI, Voinot A, Layton-Matthews D, Stoltze A, and Bowell RJ
Subjects: Minerals, Prospective Studies, Zambia, Groundwater, Water Pollutants, Chemical analysis
Abstract: Locating mineral deposits in areas of thick or transported overburden is notoriously difficult. Post-mineral cover is prevalent in many parts of the globe and has led to prospective geological sequences being missed by traditional methods of exploration. Hydrogeochemistry is particularly applicable for the exploration of Iron Oxide Copper Gold (IOCG) deposits because, when compared to larger porphyry or sediment-hosted systems, IOCG deposits tend to be smaller and high-grade with a limited lateral footprint to intersect with grid-drilling; groundwater interactions and ion dispersion tend to produce a much larger anomaly target than regolith geochemistry alone and require fewer samples. As a case study, we examine the hydrogeochemistry of the Kitumba IOCG deposit, located in the Mumbwa district of west-central Zambia. We present physicochemical data (Eh, pH, TDS, conductivity), major and trace element concentrations, and isotopic compositions (δ 98 Mo, 87 Sr/ 86 Sr, and δ 65 Cu) from groundwaters interacting with the Kitumba deposit and surrounding prospects. A hydrogeochemical footprint of As, Mo, Fe, Mn, and Zn is dispersed from the deposit. Groundwater 87 Sr/ 86 Sr values (0.708832 to 0.731807) reflect the mixing in varying proportions of waters that have interacted with distinct lithological endmembers in the Mumbwa area, corresponding to a complicated tectonic and metamorphic history. We report fractionation of 1.34 to 1.60‰ (∆ 65 Cu groundwater - chalcopyrite ) between proximal groundwater and primary chalcopyrite, which we postulate may be related to the oxidative dissolution of primary sulfide minerals. The δ 98 Mo 3134 values of groundwaters proximal to known ore bodies are isotopically distinct (-1.08 ± 0.18‰ 2SE to 0.64 ± 0.08‰ 2 SE) from background aquifers (2.08 ± 0.12‰ 2SE). The trace element and isotopic hydrogeochemical patterns described in this study document water-rock and water-deposit interactions and demonstrate the potential of non-traditional stable isotopes to be employed in district-scale reduction of exploration ground and vectoring towards undisturbed ore deposits similar to Kitumba., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Crown Copyright © 2021. Published by Elsevier B.V. All rights reserved.)
Published: 2022
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34. The β-adrenergic receptor blocker and anti-inflammatory drug propranolol mitigates brain cytokine expression in a long-term model of Gulf War Illness.

Author: Michalovicz LT, Kelly KA, Miller DB, Sullivan K, and O'Callaghan JP
Subjects: Adrenergic beta-Antagonists pharmacology, Animals, Anti-Inflammatory Agents, Non-Steroidal pharmacology, Corticosterone, Cytokines immunology, Disease Models, Animal, Encephalitis immunology, Male, Mice, Mice, Inbred C57BL, Persian Gulf Syndrome chemically induced, Persian Gulf Syndrome immunology, Propranolol pharmacology, Adrenergic beta-Antagonists therapeutic use, Anti-Inflammatory Agents, Non-Steroidal therapeutic use, Brain immunology, Cytokines antagonists & inhibitors, Encephalitis drug therapy, Persian Gulf Syndrome drug therapy, Propranolol therapeutic use
Abstract: Aims: Growing evidence suggests that Gulf War Illness (GWI) is the result of underlying neuroimmune dysfunction. For example, previously we found that several GWI-relevant organophosphate acetylcholinesterase inhibitors produce heightened neuroinflammatory responses following subchronic exposure to stress hormone as a mimic of high physiological stress. The goal of the current study was to evaluate the potential for the β-adrenergic receptor inhibitor and anti-inflammatory drug, propranolol, to treat neuroinflammation in a novel long-term mouse model of GWI., Main Methods: Adult male C57BL/6J mice received a subchronic exposure to corticosterone (CORT) at levels mimicking high physiological stress followed by exposure to the sarin surrogate, diisopropyl fluorophosphate (DFP). These mice were then re-exposed to CORT every other week for a total of five weeks, followed by a systemic immune challenge with lipopolysaccharide (LPS). Animals receiving the propranolol treatment were given a single dose (20 mg/kg, i.p.) either four or 11 days prior to the LPS challenge. The potential anti-neuroinflammatory effects of propranolol were interrogated by analysis of cytokine mRNA expression., Key Findings: We found that our long-term GWI model produces a primed neuroinflammatory response to subsequent immune challenge that is dependent upon GWI-relevant organophosphate exposure. Propranolol treatment abrogated the elaboration of inflammatory cytokine mRNA expression in the brain instigated in our model, having no treatment effects in non-DFP exposed groups., Significance: Our results indicate that propranolol may be a promising therapy for GWI with the potential to treat the underlying neuroinflammation associated with the illness., (Published by Elsevier Inc.)
Published: 2021
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35. Boston biorepository, recruitment and integrative network (BBRAIN): A resource for the Gulf War Illness scientific community.

Author: Keating D, Zundel CG, Abreu M, Krengel M, Aenlle K, Nichols MD, Toomey R, Chao LL, Golier J, Abdullah L, Quinn E, Heeren T, Groh JR, Koo BB, Killiany R, Loggia ML, Younger J, Baraniuk J, Janulewicz P, Ajama J, Quay M, Baas PW, Qiang L, Conboy L, Kokkotou E, O'Callaghan JP, Steele L, Klimas N, and Sullivan K
Subjects: Boston, Humans, Information Dissemination, Magnetic Resonance Imaging, Persian Gulf Syndrome blood, Positron-Emission Tomography, Saliva metabolism, Persian Gulf Syndrome pathology
Abstract: Aims: Gulf War Illness (GWI), a chronic debilitating disorder characterized by fatigue, joint pain, cognitive, gastrointestinal, respiratory, and skin problems, is currently diagnosed by self-reported symptoms. The Boston Biorepository, Recruitment, and Integrative Network (BBRAIN) is the collaborative effort of expert Gulf War Illness (GWI) researchers who are creating objective diagnostic and pathobiological markers and recommend common data elements for GWI research., Main Methods: BBRAIN is recruiting 300 GWI cases and 200 GW veteran controls for the prospective study. Key data and biological samples from prior GWI studies are being merged and combined into retrospective datasets. They will be made available for data mining by the BBRAIN network and the GWI research community. Prospective questionnaire data include general health and chronic symptoms, demographics, measures of pain, fatigue, medical conditions, deployment and exposure histories. Available repository biospecimens include blood, plasma, serum, saliva, stool, urine, human induced pluripotent stem cells and cerebrospinal fluid., Key Findings: To date, multiple datasets have been merged and combined from 15 participating study sites. These data and samples have been collated and an online request form for repository requests as well as recommended common data elements have been created. Data and biospecimen sample requests are reviewed by the BBRAIN steering committee members for approval as they are received., Significance: The BBRAIN repository network serves as a much needed resource for GWI researchers to utilize for identification and validation of objective diagnostic and pathobiological markers of the illness., (Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.)
Published: 2021
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36. A randomized phase II remote study to assess Bacopa for Gulf War Illness associated cognitive dysfunction: Design and methods of a national study.

Author: Cheema AK, Wiener LE, McNeil RB, Abreu MM, Craddock T, Fletcher MA, Helmer DA, Ashford JW, Sullivan K, and Klimas NG
Subjects: Aged, Humans, Male, Middle Aged, Bacopa, Cognitive Dysfunction drug therapy, Persian Gulf Syndrome drug therapy, Veterans
Abstract: Aims: Gulf War Illness (GWI) is a chronic, debilitating, multi-symptom condition affecting as many as one-third of the nearly 700,000 U.S. troops deployed to the Middle East during the 1990-1991 Gulf War (GW). The treatment of GWI relies on symptom management. A common challenge in studying the efficacy of interventions for symptom management is participant recruitment related to factors such as the burden of travelling to study sites and the widespread dispersion of Veterans with GWI. The goal of this study is to assess the efficacy of a novel low-risk therapeutic agent, Bacopa monnieri, for cognitive function in Veterans with GWI and to evaluate the utility of a remote patient-centric study design developed to promote recruitment and minimize participant burden., Main Methods: To promote effective participant recruitment, we developed a remote patient-centric study design. Participants will be recruited online through social media and through a web-based research volunteer list of GW Veterans. An online assessment platform will be used, and laboratory blood draws will be performed at clinical laboratory sites that are local to participants. Furthermore, the assigned intervention will be mailed to each participant., Significance: These study design adaptations will open participation to Veterans nearly nationwide and reduce administrative costs while maintaining methodologic rigor and participant safety in a randomized, placebo-controlled phase II clinical trial., (Copyright © 2021 Elsevier Inc. All rights reserved.)
Published: 2021
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37. Elevated somatic mutation and evidence of genomic instability in veterans with Gulf War illness.

Author: Grant SG, Ibrahim OM, Jin XL, Klimas NG, Sullivan K, and Latimer JJ
Subjects: Case-Control Studies, Glycophorins genetics, Humans, Male, Genomic Instability, Mutation, Persian Gulf Syndrome genetics, Veterans
Abstract: Aims: Gulf War illness (GWI) is thought to be associated with exposures experienced by soldiers deployed in the 1991 Gulf War. A major question is how these exposures continue to influence the health of these individuals three decades later. One potentially permanent effect of such exposures is the induction of genetic mutations. We investigated whether veterans with GWI exhibited persistently elevated levels of somatic mutation., Materials and Methods: We applied the blood-based glycophorin A (GPA) somatic mutation assay to a cohort of veterans diagnosed with GWI and a set of both concurrent and historic age-matched controls. This assay quantifies red blood cells with a phenotype consistent with loss of one allele at the genetic determinant for the MN blood group, the GPA gene., Key Findings: As a population, those affected with GWI exhibited an uninduced mutation frequency at the GPA locus that was effectively twice that observed in controls, a result that was statistically significant. This result was influenced by an increase in the incidence of individuals with aberrantly high mutation frequencies, seemingly higher than would be expected by dose extrapolation and consistent with the induction of localized genomic instability in the hematopoietic bone marrow stem cells. When these "outliers" were removed from consideration, the remaining affected population retained a significantly higher mean allele loss mutation frequency, suggesting that both dose-dependent bone marrow genotoxicity and induction of genomic instability are contributing to the elevation in mutation frequency in these affected veterans., Significance: This study provides evidence that manifestation of GWI is associated with increased cumulative exposure to agents capable of inducing persistent mutations in bone marrow stem cells. Whether these mutations are involved in the clinical aspects of the condition or are simply biomarkers of overall exposure has yet to be determined. The increased incidence of genomic instability suggests that this persistent mutation can have important delayed effects on cellular integrity., (Copyright © 2021 Elsevier Inc. All rights reserved.)
Published: 2021
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38. Neurotoxicant exposures and rates of Chronic Multisymptom Illness and Kansas Gulf War Illness criteria in Gulf War deployed women veterans.

Author: Krengel M, Sullivan K, Heboyan V, Zundel CG, Wilson CC, Klimas N, and Coughlin SS
Subjects: Biological Warfare Agents, Chemical Warfare Agents adverse effects, Cholinesterase Inhibitors adverse effects, Chronic Disease, Female, Gulf War, Humans, Kansas epidemiology, Middle Aged, Persian Gulf Syndrome epidemiology, Pesticides adverse effects, Pyridostigmine Bromide adverse effects, Smoke adverse effects, Veterans, Environmental Exposure adverse effects, Neurotoxins adverse effects, Persian Gulf Syndrome chemically induced
Abstract: Aims: This study analyzed deployment-related exposures and risk of Persian Gulf War Illness (GWI) in women veterans from the Veterans Affairs (VA) Cooperative Studies Program 585 Gulf War Era Cohort and Biorepository (GWECB CSP#585)., Main Methods: We examined the associations between GW deployment-related exposures and case definitions for GWI in deployed GW women. Multivariate regression analyses controlling for demographic outcomes were performed., Key Findings: Surveys were obtained from 202 GW deployed women veterans. Self-reported exposure to smoke from oil well fires as well as chemical and biological warfare were the only exposures significantly associated with the Center for Disease Control and Prevention (CDC) GWI criteria. Seventy-nine women were excluded from the rest of the analyses as they met Kansas GW illness exclusion criteria. Eligible women who self-reported deployment-related exposure to smoke from oil wells, pyridostigmine bromide (PB) pills, pesticide cream, pesticide treated uniforms, and insect baits were significantly more likely to meet the Kansas GWI criteria (n = 123) than those unexposed and exposures were related to Kansas symptom subdomain endorsements., Significance: These results suggest that women GW veterans reporting deployment related exposures of pesticide, oil well fire and PB pills are significantly more likely to meet the Kansas GWI criteria in this national cohort of GW women suggesting its utility in future studies. In addition, based on these results it appears that women exposed to particular toxicants during the war may benefit from more targeted treatment strategies dependent upon the mechanism of exposure of their toxicant induced outcomes., (Copyright © 2021. Published by Elsevier Inc.)
Published: 2021
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39. Gulf War Illness Clinical Trials and Interventions Consortium (GWICTIC): A collaborative research infrastructure for intervention and implementation.

Author: Cheema AK, McNeil RB, Craddock T, Broderick G, Abreu MM, Aenlle K, Helmer DA, Ashford JW, Sullivan K, Bested A, Cohen DE, Shungu D, Chandler H, Fletcher MA, Krengel M, and Klimas N
Subjects: Biomedical Research, Clinical Trials as Topic, Disease Management, Gulf War, Humans, Persian Gulf Syndrome diagnosis, Research Design, Persian Gulf Syndrome therapy, Veterans Health
Abstract: Aims: There is an inadequate portfolio of treatments for Gulf War Illness (GWI), a complex disease involving multiple organ systems, and early-phase clinical trials are hampered by many logistical problems. To address these challenges, the Gulf War Illness Clinical Trials and Interventions Consortium (GWICTIC) was formed with the aims of (i) creating a collaborative consortium of clinical and scientific researchers that will rapidly implement rigorous and innovative phase I and II clinical trials for GWI, (ii) perform at least four phase I or II clinical trials, (iii) provide a foundation of scalable infrastructure and management in support of the efficient and successful operation of the GWICTIC, and (iv) partner with the Boston Biorepository, Recruitment & Integrated Network for GWI and other GWI investigators to develop a common data element platform for core assessments and outcomes., Main Methods: The GWICTIC brings together a multidisciplinary team of researchers at several institutions to provide scientific innovation, statistical and computational rigor, and logistical efficiency in the development and implementation of early-phase low-risk clinical trials for GWI. The GWICTIC core trials adhere to a Veteran-centered philosophy and focus on interventions with multiple mechanistic targets to maximize the likelihood of efficacy. To support rapid and efficient study startup and implementation across the GWI research community, the GWICTIC will share infrastructure with investigator-initiated research studies funded under separate mechanisms., Significance: The GWICTIC will leverage the efficiencies of centralized research support and innovative trial designs to address several longstanding needs in the GWI interventions research community., (Copyright © 2021. Published by Elsevier Inc.)
Published: 2021
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40. Endobronchial Ultrasound Staging of Operable Non-small Cell Lung Cancer: Do Triple-Normal Lymph Nodes Require Routine Biopsy?

Author: Hylton DA, Kidane B, Spicer J, Turner S, Churchill I, Sullivan K, Finley CJ, Shargall Y, Agzarian J, Seely AJE, Yasufuku K, and Hanna WC
Subjects: Aged, Aged, 80 and over, Bronchi, Carcinoma, Non-Small-Cell Lung secondary, Carcinoma, Non-Small-Cell Lung surgery, Female, Follow-Up Studies, Humans, Lung Neoplasms surgery, Lymphatic Metastasis diagnostic imaging, Male, Mediastinum, Middle Aged, Prospective Studies, Carcinoma, Non-Small-Cell Lung diagnosis, Endoscopic Ultrasound-Guided Fine Needle Aspiration methods, Endosonography methods, Lung Neoplasms diagnosis, Lymph Nodes diagnostic imaging, Pneumonectomy
Abstract: Background: Staging guidelines for lung cancer recommend endobronchial ultrasound (EBUS) and systematic biopsy of at least three mediastinal lymph node (LN) stations for accurate staging. A four-point ultrasonographic score (Canada Lymph Node Score [CLNS]) was developed to determine the probability of malignancy in each LN. A LN with a CLNS of < 2 is considered low probability for malignancy. We hypothesized that, in patients with cN0 non-small cell lung cancer, LNs with CLNS of < 2 may not require routine biopsy because they represent true node-negative disease., Research Question: Do LNs considered triple normal on CT scanning, PET scanning, and CLNS evaluation require routine biopsy?, Study Design and Methods: LNs were evaluated for ultrasonographic features at the time of EBUS and the CLNS was applied. Triple-normal LNs were defined as cN0 on CT scanning (short axis, < 1 cm), PET scanning (no hypermetabolic activity), and EBUS (CLNS, < 2). Specificity and negative predictive value (NPV) were calculated against the gold standard pathologic diagnosis from surgically excised specimens., Results: In total, 143 LNs from 57 cN0 patients were assessed. Triple-normal LNs showed a specificity and NPV of 60% (95% CI, 51.2%-68.3%) and 93.1% (95% CI, 85.6%-97.4%), respectively. After pathologic assessment, only 5.6% (n = 8/143) of triple-normal nodes were proven to be malignant., Interpretation: At the time of staging for lung cancer, combining CT scanning, PET scanning, and CLNS criteria can identify triple-normal LNs that have a high NPV for malignancy. This raises the question of whether triple-normal LNs require routine sampling during EBUS and transbronchial needle aspiration. A prospective trial is required to confirm these findings., (Copyright © 2021 American College of Chest Physicians. Published by Elsevier Inc. All rights reserved.)
Published: 2021
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41. Sex-Specific Differences in Heart Failure: Pathophysiology, Risk Factors, Management, and Outcomes.

Author: Sullivan K, Doumouras BS, Santema BT, Walsh MN, Douglas PS, Voors AA, and Van Spall HGC
Subjects: Cardiac Resynchronization Therapy, Cardiovascular Agents therapeutic use, Defibrillators, Implantable, Female, Healthcare Disparities, Heart Failure physiopathology, Heart Transplantation, Heart-Assist Devices, Humans, Male, Randomized Controlled Trials as Topic, Referral and Consultation, Research Subjects, Risk Factors, Sex Factors, Heart Failure therapy
Abstract: Heart failure (HF) is a leading cause of hospitalisation, morbidity, and mortality in Canada. There are sex-specific differences in the etiology, epidemiology, comorbidities, treatment response, and treatment adverse effects that have implications on outcomes in HF. Sex-specific analyses of some HF trials indicate that optimal doses of drug therapies and benefit of device therapies may differ between male and female patients, but the trials were not designed to test sex differences. The under-representation of female participants in HF randomised controlled trials (RCTs) is a major limitation in assessing the sex-specific efficacy and safety of treatments. To ensure that female patients receive safe and effective HF therapies, RCTs should include participants proportionate to the sex-specific distribution of disease. This review outlines the sex-specific differences in HF phenotype and treatment response, and highlights disparities in services and gaps in knowledge that merit further investigation., (Copyright © 2020 Canadian Cardiovascular Society. Published by Elsevier Inc. All rights reserved.)
Published: 2021
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42. A role for neuroimmune signaling in a rat model of Gulf War Illness-related pain.

Author: Lacagnina MJ, Li J, Lorca S, Rice KC, Sullivan K, O'Callaghan JP, and Grace PM
Subjects: Animals, Disease Models, Animal, Gulf War, Male, Pain, Rats, Rats, Sprague-Dawley, Persian Gulf Syndrome chemically induced
Abstract: More than a quarter of veterans of the 1990-1991 Persian Gulf War suffer from Gulf War Illness (GWI), a chronic, multi-symptom illness that commonly includes musculoskeletal pain. Exposure to a range of toxic chemicals, including sarin nerve agent, are a suspected root cause of GWI. Moreover, such chemical exposures induce a neuroinflammatory response in rodents, which has been linked to several GWI symptoms in rodents and veterans with GWI. To date, a neuroinflammatory basis for pain associated with GWI has not been investigated. Here, we evaluated development of nociceptive hypersensitivity in a model of GWI. Male Sprague Dawley rats were treated with corticosterone in the drinking water for 7 days, to mimic high physiological stress, followed by a single injection of the sarin nerve agent surrogate, diisopropyl fluorophosphate. These exposures alone were insufficient to induce allodynia. However, an additional sub-threshold challenge (a single intramuscular injection of pH 4 saline) induced long-lasting, bilateral allodynia. Such allodynia was associated with elevation of markers for activated microglia/macrophages (CD11b) and astrocytes/satellite glia (GFAP) in the lumbar dorsal spinal cord and dorsal root ganglia (DRG). Additionally, Toll-like receptor 4 (TLR4) mRNA was elevated in the lumbar dorsal spinal cord, while IL-1β and IL-6 were elevated in the lumbar dorsal spinal cord, DRG, and gastrocnemius muscle. Demonstrating a casual role for such neuroinflammatory signaling, allodynia was reversed by treatment with either minocycline, the TLR4 inhibitor (+)-naltrexone, or IL-10 plasmid DNA. Together, these results point to a role for neuroinflammation in male rats in the model of musculoskeletal pain related to GWI. Therapies that alleviate persistent immune dysregulation may be a strategy to treat pain and other symptoms of GWI., (Copyright © 2020 Elsevier Inc. All rights reserved.)
Published: 2021
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43. Alterations in high-order diffusion imaging in veterans with Gulf War Illness is associated with chemical weapons exposure and mild traumatic brain injury.

Author: Cheng CH, Koo BB, Calderazzo S, Quinn E, Aenlle K, Steele L, Klimas N, Krengel M, Janulewicz P, Toomey R, Michalovicz LT, Kelly KA, Heeren T, Little D, O'Callaghan JP, and Sullivan K
Subjects: Animals, Brain diagnostic imaging, Gulf War, Humans, Brain Concussion diagnostic imaging, Persian Gulf Syndrome diagnostic imaging, Veterans
Abstract: The complex etiology behind Gulf War Illness (GWI) has been attributed to the combined exposure to neurotoxicant chemicals, brain injuries, and some combat experiences. Chronic GWI symptoms have been shown to be associated with intensified neuroinflammatory responses in animal and human studies. To investigate the neuroinflammatory responses and potential causes in Gulf War (GW) veterans, we focused on the effects of chemical/biological weapons (CBW) exposure and mild traumatic brain injury (mTBI) during the war. We applied a novel MRI diffusion processing method, Neurite density imaging (NDI), on high-order diffusion imaging to estimate microstructural alterations of brain imaging in Gulf War veterans with and without GWI, and collected plasma proinflammatory cytokine samples as well as self-reported health symptom scores. Our study identified microstructural changes specific to GWI in the frontal and limbic regions due to CBW and mTBI, and further showed distinctive microstructural patterns such that widespread changes were associated with CBW and more focal changes on diffusion imaging were observed in GW veterans with an mTBI during the war. In addition, microstructural alterations on brain imaging correlated with upregulated blood proinflammatory cytokine markers TNFRI and TNFRII and with worse outcomes on self-reported symptom measures for fatigue and sleep functioning. Taken together, these results suggest TNF signaling mediated inflammation affects frontal and limbic regions of the brain, which may contribute to the fatigue and sleep symptoms of the disease and suggest a strong neuroinflammatory component to GWI. These results also suggest exposures to chemical weapons and mTBI during the war are associated with different patterns of peripheral and central inflammation and highlight the brain regions vulnerable to further subtle microscale morphological changes and chronic signaling to nearby glia., (Copyright © 2020 Elsevier Inc. All rights reserved.)
Published: 2020
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44. Investigation of Dalea parryi (Fabaceae) metabolites for anthelmintic activity against the human pathogenic hookworm Ancylostoma ceylanicum.

Author: Belofsky G, Engels L, McPherson V, Nash K, Sullivan K, Torrey B, Ripley C, Coria A, Bicchieri T, and Dondji B
Subjects: Adult, Ancylostoma, Ancylostomatoidea, Animals, Humans, Plant Roots, Anthelmintics, Fabaceae
Abstract: The US Southwest plant Dalea parryi (Fabaceae) was investigated as part of an ongoing study of the potential of plant compounds for anthelmintic activity to the human pathogenic hookworm Ancylostoma ceylanicum. This has resulted in the isolation of three previously undescribed isoflavonoid metabolites, denoted parryans A-C, a chalcone, six pterocarpans, and three known compounds from the roots of D. parryi. Parryans A and B express a rarely-seen O-prenyl substituent. Structures of the previously undescribed compounds were established using 1D and 2D NMR spectroscopy and mass spectrometry. The relative and absolute configurations of the undescribed stereoisomers were assigned using chemical shift and coupling constant data and comparisons of specific rotations to published data. The most active of the isolated compounds only expressed a 17% reduction in survival of A. ceylanicum adult hookworm in an ex vivo assay at 50 μg/mL after 5 days exposure. Toxicity, ranging from 47 to 93% reduction in survival of mammalian splenocytes was expressed by four of the compounds., (Copyright © 2020 Elsevier Ltd. All rights reserved.)
Published: 2020
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45. Acute toxicity "six-pack" studies supporting approved new drug applications in the U.S., 2015-2018.

Author: Manuppello J, Sullivan K, and Baker E
Subjects: Animals, Humans, United States, United States Food and Drug Administration, Animal Testing Alternatives, Pharmaceutical Preparations analysis, Toxicity Tests, Acute
Abstract: The acute toxicity "six-pack" is a battery of animal tests used to evaluate acute systemic toxicity by three routes of exposure, skin and eye irritation/corrosion, and skin sensitization. A perception exists that these tests are not required for pharmaceuticals. For the four years from 2015 through 2018, we tallied the number of corresponding tests submitted by sponsors in approved, original new drug applications, as reported by the U.S. Food and Drug Administration (FDA) in publicly available reviews. In 125 reviews, we identified 228 single dose acute toxicity studies, 62 in vivo local tolerance studies, and 32 in vivo skin sensitization studies, as well as 37 in vitro or ex vivo local tolerance studies. A total of 4798 animals were used in these studies; however, FDA's reporting was inconsistent, and we estimate the actual number of animals used to be 8998. For the evaluation of single dose acute toxicity, we accessed two guidance documents with conflicting recommendations regarding routes of administration and number of species to be used. For the evaluation of local tolerance and skin sensitization, most studies examined were conducted by routes other than that intended for human administration. Non-animal methods used to evaluate skin sensitization were not reported., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.)
Published: 2020
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46. In-vivo imaging of neuroinflammation in veterans with Gulf War illness.

Author: Alshelh Z, Albrecht DS, Bergan C, Akeju O, Clauw DJ, Conboy L, Edwards RR, Kim M, Lee YC, Protsenko E, Napadow V, Sullivan K, and Loggia ML
Subjects: Astrocytes, Gulf War, Humans, Pyridostigmine Bromide, Receptors, GABA, Persian Gulf Syndrome diagnostic imaging, Veterans
Abstract: Gulf War Illness (GWI) is a chronic disorder affecting approximately 30% of the veterans who served in the 1991 Gulf War. It is characterised by a constellation of symptoms including musculoskeletal pain, cognitive problems and fatigue. The cause of GWI is not definitively known but exposure to neurotoxicants, the prophylactic use of pyridostigmine bromide (PB) pills, and/or stressors during deployment have all been suspected to play some pathogenic role. Recent animal models of GWI have suggested that neuroinflammatory mechanisms may be implicated, including a dysregulated activation of microglia and astrocytes. However, neuroinflammation has not previously been directly observed in veterans with GWI. To measure GWI-related neuroinflammation in GW veterans, we conducted a Positron Emission Tomography (PET) study using [ 11 C]PBR28, which binds to the 18 kDa translocator protein (TSPO), a protein upregulated in activated microglia/macrophages and astrocytes. Veterans with GWI (n = 15) and healthy controls (HC, n = 33, including a subgroup of healthy GW veterans, HC VET , n = 8), were examined using integrated [ 11 C]PBR28 PET/MRI. Standardized uptake values normalized by occipital cortex signal (SUVR) were compared across groups and against clinical variables and circulating inflammatory cytokines (TNF-α, IL-6 and IL-1β). SUVR were validated against volume of distribution ratio (n = 13). Whether compared to the whole HC group, or only the HC VET subgroup, veterans with GWI demonstrated widespread cortical elevations in [ 11 C]PBR28 PET signal, in areas including precuneus, prefrontal, primary motor and somatosensory cortices. There were no significant group differences in the plasma levels of the inflammatory cytokines evaluated. There were also no significant correlations between [ 11 C]PBR28 PET signal and clinical variables or circulating inflammatory cytokines. Our study provides the first direct evidence of brain upregulation of the neuroinflammatory marker TSPO in veterans with GWI and supports the exploration of neuroinflammation as a therapeutic target for this disorder., (Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.)
Published: 2020
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47. Correspondence: Reply to Hopayian.

Author: Lim YZ, Chou L, Au RT, Seneviwickrama KMD, Cicuttini FM, Briggs AM, Sullivan K, Urquhart DM, and Wluka AE
Subjects: Humans, Prognosis, Low Back Pain, Self-Management
Published: 2020
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48. A permethrin metabolite is associated with adaptive immune responses in Gulf War Illness.

Author: Joshi U, Pearson A, Evans JE, Langlois H, Saltiel N, Ojo J, Klimas N, Sullivan K, Keegan AP, Oberlin S, Darcey T, Cseresznye A, Raya B, Paris D, Hammock B, Vasylieva N, Hongsibsong S, Stern LJ, Crawford F, Mullan M, and Abdullah L
Subjects: Adult, Animals, Benzoates analysis, Brain metabolism, Central Nervous System metabolism, Disease Models, Animal, Female, Gulf War, Humans, Male, Mice, Mice, Inbred C57BL, Middle Aged, Permethrin metabolism, Persian Gulf Syndrome physiopathology, Pyridostigmine Bromide adverse effects, Pyridostigmine Bromide metabolism, Veterans, Adaptive Immunity drug effects, Permethrin adverse effects, Persian Gulf Syndrome metabolism
Abstract: Gulf War Illness (GWI), affecting 30% of veterans from the 1991 Gulf War (GW), is a multi-symptom illness with features similar to those of patients with autoimmune diseases. The objective of the current work is to determine if exposure to GW-related pesticides, such as permethrin (PER), activates peripheral and central nervous system (CNS) adaptive immune responses. In the current study, we focused on a PER metabolite, 3-phenoxybenzoic acid (3-PBA), as this is a common metabolite previously shown to form adducts with endogenous proteins. We observed the presence of 3-PBA and 3-PBA modified lysine of protein peptides in the brain, blood and liver of pyridostigmine bromide (PB) and  PER (PB+PER) exposed mice at acute and chronic post-exposure timepoints. We tested whether 3-PBA-haptenated albumin (3-PBA-albumin) can activate immune cells since it is known that chemically haptenated proteins can stimulate immune responses. We detected autoantibodies against 3-PBA-albumin in plasma from PB + PER exposed mice and veterans with GWI at chronic post-exposure timepoints. We also observed that in vitro treatment of blood with 3-PBA-albumin resulted in the activation of B- and T-helper lymphocytes and that these immune cells were also increased in blood of PB + PER exposed mice and veterans with GWI. These immune changes corresponded with elevated levels of infiltrating monocytes in the brain and blood of PB + PER exposed mice which coincided with alterations in the markers of blood-brain barrier disruption, brain macrophages and neuroinflammation. These studies suggest that pesticide exposure associated with GWI may have resulted in the activation of the peripheral and CNS adaptive immune responses, possibly contributing to an autoimmune-type phenotype in veterans with GWI., (Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.)
Published: 2019
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49. People with low back pain want clear, consistent and personalised information on prognosis, treatment options and self-management strategies: a systematic review.

Author: Lim YZ, Chou L, Au RT, Seneviwickrama KMD, Cicuttini FM, Briggs AM, Sullivan K, Urquhart DM, and Wluka AE
Subjects: Humans, Patient Education as Topic, Prognosis, Attitude to Health, Health Services Needs and Demand, Low Back Pain psychology, Low Back Pain therapy, Self-Management
Abstract: Question: What health information needs are perceived by people with low back pain?, Design: Systematic review of publications examining perceived health information needs related to low back pain identified through Medline, EMBASE, CINAHL and PsycINFO (1990 to 2018)., Participants: Adults with low back pain of any duration., Data Extraction and Analysis: Two reviewers independently extracted descriptive data regarding study design and methodology, and assessed risk of bias. Aggregated findings of the perceived needs of people with low back pain regarding health information were meta-synthesised., Results: Forty-one studies (34 qualitative, four quantitative and three mixed-methods) were identified. Two major areas of perceived health information needs for low back pain emerged. The first major area was needs related to information content: general information related to low back pain, its cause and underlying pathology; strong desire for diagnosis and imaging; prognosis, future disability and effect on work capacity; precipitants and management of flares; general management approaches; self-management strategies; prevention; and support services. The second major area of needs related to how the information was delivered. People with low back pain wanted clear, consistent information delivered in suitable tone and understandable language., Conclusion: Available data suggest that the information needs of people with low back pain are centred around their desire for a diagnosis, potentially contributing to expectations for and overuse of imaging. People with low back pain expressed a strong desire for clear, consistent and personalised information on prognosis, treatment options and self-management strategies, related to healthcare and occupational issues. To correct unhelpful beliefs and optimise delivery of evidence-based therapy, patient and healthcare professional education (potentially by an integrated public health approach) may be warranted., (Copyright © 2019 Australian Physiotherapy Association. Published by Elsevier B.V. All rights reserved.)
Published: 2019
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50. Capacity assessment and estate planning - the therapeutic importance of the individual.

Author: Purser K and Sullivan K
Subjects: Forensic Psychiatry legislation & jurisprudence, Forensic Psychiatry methods, Fraud prevention & control, Fraud psychology, Humans, Intellectual Disability diagnosis, Intellectual Disability psychology, Wills, Financial Management, Mental Competency legislation & jurisprudence, Mental Competency psychology
Abstract: Demand for legal capacity assessments is increasing, especially assessments of financial capacity for estate planning purposes such as wills and enduring powers of attorney. This article proposes that such assessments will be improved by taking greater account of the client experience, including individual and relational factors and processes, and considering the practice framework. A literature review was undertaken with a two-fold aim: firstly, to understand the fundamentally important perspective (inclusive of these experiences) of the evaluee; and, secondly, to identify potential improvements in the capacity assessment process with a view to informing best practice. No studies were identified that directly addressed the individual perspective in capacity assessments. Case studies and commentaries that indirectly discuss the individual perspective were therefore analysed to identify any potential issues and recommendations. This analysis showed that individual factors, such as the evaluee's functional and disease status, and relational factors, such as trust, should be considered by examiners. This review demonstrates that there is a significant gap in the literature examining the individual's perspective and experiences in capacity assessments, as well as, any impact this may have on the assessment process and outcomes. Further research into this vital perspective is needed so that the experiences of those undergoing assessments can help inform best practice and ensure that optimal processes are adopted when assessing the capacity necessary to make legally recognised decisions. This article examines the importance of the participant perspective and experiences in capacity assessments through the novel lens of therapeutic jurisprudence. It includes practice suggestions and provides the direction for this future research., (Copyright © 2019 Elsevier Ltd. All rights reserved.)
Published: 2019
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