1. Cognitive impairment and frontal-subcortical geriatric syndrome are associated with metabolic syndrome in a stroke-free population.
- Author
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Roriz-Cruz M, Rosset I, Wada T, Sakagami T, Ishine M, De Sá Roriz-Filho J, Cruz TR, Hosseinkhani M, Rodrigues RP, Sudoh S, Arai H, Wakatsuki Y, Souza AC, Nakagawa M, Kita T, and Matsubayashi K
- Subjects
- Aged, Aged, 80 and over, Aging metabolism, Aging pathology, Brazil epidemiology, Cerebrovascular Circulation physiology, Cerebrovascular Disorders epidemiology, Cerebrovascular Disorders metabolism, Cerebrovascular Disorders physiopathology, Cognition Disorders metabolism, Cognition Disorders physiopathology, Comorbidity, Dementia, Vascular metabolism, Dementia, Vascular physiopathology, Depressive Disorder epidemiology, Depressive Disorder metabolism, Depressive Disorder physiopathology, Dyslipidemias complications, Dyslipidemias physiopathology, Female, Frontal Lobe blood supply, Frontal Lobe physiopathology, Humans, Insulin Resistance physiology, Male, Metabolic Syndrome metabolism, Metabolic Syndrome physiopathology, Middle Aged, Movement Disorders epidemiology, Movement Disorders metabolism, Movement Disorders physiopathology, Neural Pathways blood supply, Neural Pathways physiopathology, Prevalence, Risk Factors, Stroke epidemiology, Urinary Incontinence epidemiology, Urinary Incontinence metabolism, Urinary Incontinence physiopathology, Cognition Disorders epidemiology, Dementia, Vascular epidemiology, Frontal Lobe pathology, Metabolic Syndrome epidemiology, Neural Pathways pathology
- Abstract
Background: Metabolic syndrome (Met.S) consists of a conglomeration of obesity, hypertension, glucose intolerance, and dislipidemia. Frontal-subcortical geriatric syndrome (FSCS) is caused by ischemic disruption of the frontal-subcortical network. It is unknown if Met.S is associated with FSCS., Methods: We evaluated 422 community-dwelling elderly (> or =60) in Brazil. FSCS was defined as the presence of at least one frontal release sign (grasping, palmomental, snout, or glabellar) plus coexistence of > or =3 the following criteria: (1) cognitive impairment, (2) late-onset depression, (3) neuromotor dysfunction, and (4) urgency incontinence. All values were adjusted to age and gender., Results: Met.S was present in 39.3% of all subjects. Cases without any of the FSCS components represented 37.2% ('successful neuroaging' group). People with 1-3 of the FSCS components ('borderline pathological neuroaging' group) were majority (52.6%), whereas those with 4-5 of these components (FSCS group) were minority (10.2%). Met.S was significantly associated with FSCS (OR=5.9; CI: 1.5-23.4) and cognitive impairment (OR=2.2; CI: 1.1-4.6) among stroke-free subjects. Number of Met.S components explained 30.7% of the variance on the number of FSCS criteria (P<0.001). If Met.S were theoretically removed from this population, prevalence of FSCS would decline by 31.6% and that of cognitive impairment by 21.4%., Conclusions: Met.S was significantly associated with a 5.9 and 2.2 times higher chance of FSCS and cognitive impairment, respectively. Met.S might be a major determinant of 'successful' or 'pathological' neuroaging in western societies.
- Published
- 2007
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