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Background: Fatigue is common among patients with inflammatory bowel diseases (IBDs) and is associated with decreased quality of life (QoL)., Aims: Describe fatigue evolution and identify factors associated with fatigue outcomes in patients with ulcerative colitis (UC) or Crohn's disease (CD) initiating biologic treatment., Methods: Data from adult Belgian patients with UC or CD enrolled in a prospective real-world study were utilized. Fatigue and QoL were assessed using the Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F) and the Short Inflammatory Bowel Disease Questionnaire, respectively. Factors associated with fatigue outcomes were assessed using multivariate regression., Results: 465 patients were included: 174 with UC and 291 with CD. Average FACIT-F scores indicated improvements in fatigue after 6 months, before stabilizing. A higher probability of fatigue disappearance was associated with clinical remission and was more likely in patients with UC than CD. Patients achieving clinical remission had lower probability of fatigue. Patients with fatigue improvements experienced greater QoL improvements than patients with fatigue persistence., Conclusions: Real-world findings suggest fatigue partly improves in the first 6 months of biologic treatment. Clinical remission was associated with greater probability of fatigue disappearance and lower likelihood of fatigue persistence. Further research into factors associated with fatigue in patients with IBD is warranted., Competing Interests: Conflict of interest E.L. reports educational and research grants from AbbVie, Fresenius Kabi, Janssen, Pfizer, and Takeda; speaker fees from AbbVie, Bristol Myers Squibb, Celgene, Dr Falk, Ferring, Galapagos, Janssen, Pfizer, and Takeda; serving on advisory boards for AbbVie, Arena, Bristol Myers Squibb, Celgene, Eli Lilly, Ferring, Gilead-Galapagos, Janssen, Pfizer, and Takeda; and being a consultant for AbbVie. P.B. reports research grants from AbbVie, Amgen, Celltrion, Mylan, Pfizer, and Takeda; lecture fees from AbbVie, Celltrion, Eli Lilly, Janssen, and Takeda; and consulting fees from AbbVie, Arena, Bristol Myers Squibb, Celltrion, Dr Falk, Eli Lilly, Galapagos, Janssen, Pentax, PSI-CRO, Roche, Takeda, and Tetrameros. A.C. reports consultancy fees from AbbVie, Galapagos, Janssen, and Takeda; and speaker fees from AbbVie, Celltrion, Galapagos, Janssen, and Pfizer. S.V. reports grants from AbbVie, Galapagos, Johnson & Johnson, Pfizer, and Takeda; and consulting and/or speaker fees from AbbVie, AbolerIS, AgomAb, Alimentiv, Arena, AstraZeneca, Avaxia, Boehringer Ingelheim, Bristol Myers Squibb, Celgene, CVasThera, Cytoki, Dr Falk, Eli Lilly, Ferring, Galapagos, Genentech-Roche, Gilead, GSK, Hospira, Imidomics, Janssen, Johnson & Johnson, Materia Prima, Merck Sharp & Dohme, MiroBio, Morphic, MrMHealth, Mundipharma, Pfizer, Prodigest, Progenity, Prometheus, Robarts Clinical Trials, Second Genome, Shire, Surrozen, Takeda, Theravance, Tillots, and Zealand. V.S. reports receiving a research grant from Takeda. F.B. reports grant/research support from AbbVie, Amgen, Janssen, and Takeda; being a speaker for AbbVie, Celltrion, Ferring Holding SA, Janssen, Merck Sharp & Dohme, Pfizer, and Takeda; honoraria from AbbVie, Amgen, Arena, Celltrion, Ferring Holding SA, Fresenius Kabi AG, Galapagos, Janssen, Merck Sharp & Dohme, Pfizer, and Takeda. F.F. reports research grants from Takeda. A.H. and G.V.G. are employees of Takeda. J.Z. is an employee of and holds stock/stock options in Takeda. The other authors declare no conflicts of interest., (Copyright © 2024. Published by Elsevier Ltd.)

An immunocompetent patient without a history of recent travel or animal exposure developed persistent abdominal bloating and cramps without diarrhoea or fever. Negative additional investigations excluded gastritis, infectious colitis, inflammatory bowel disease and neoplasia, but routine stool culture detected a Campylobacter -like organism. The isolate was obtained with use of a polycarbonate filter technique, emphasizing the importance of culture to support and validate the occurrence of emerging and new bacterial enteric pathogens. The ensuing extensive laboratory examinations proved challenging in identifying this potential pathogen. Phylogenetic marker analysis based on the 16S ribosomal RNA and rpoB gene sequences revealed that the isolate was most closely related to Arcobacter lanthieri and Arcobacter faecis . Subsequent analysis of a draft whole genome sequence assigned the isolate to A. lanthieri . We report the presence of five virulence genes, cadF , ciaB , mviN , hecA and iroE , indicating a possible pathogenic nature of this organism. This case demonstrated the importance of the use of agnostic methods for the detection of emerging pathogens in cases of enteric disease with a wide array of gastrointestinal symptoms., (© 2020 The Authors.)