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1. Tumor necrosis factor-alpha production-regulating activity of phthalimide derivatives in genetically modified murine melanoma cells B78H1.

Author

Orzeszko A, Lasek W, Switaj T, Stoksik M, and Kamińska B

Subjects
Animals, Drug Design, Melanoma, Mice, Phthalimides pharmacology, Tumor Cells, Cultured, Zidovudine pharmacology, Phthalimides chemical synthesis, Tumor Necrosis Factor-alpha biosynthesis, Zidovudine analogs & derivatives, Zidovudine chemical synthesis
Abstract

The effect of imides, monothioimides, trimellitimides, as well as 5'-deoxy-5'-phthaloylamino-derivatives of azidothymidine on tumor necrosis factor-alpha (TNF-alpha) production by genetically modified murine B78H1 melanoma cells transduced with the gene for human TNF-alpha (B78/TNF) was investigated. It was found that N-(adamant-1-yl)monothiophthalimide (1e) and N-(adamant-2-yl)-monothiophthalimide (1f) showed over 200% enhancing of TNF-alpha production while some of imides were inhibitors.

Published
2003
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