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6 results on '"Stephen K. Durham"'

1. Risk Assessment

Author

Stephen K. Durham, Daniel G. Rudmann, Keegan C. Rudmann, and James A. Swenberg

Published
2023

2. Contributors

Author

Basel T. Assaf, Adam D. Aulbach, Virunya Bhat, Brad Bolon, William M. Bracken, Alys E. Bradley, Glenn H. Cantor, Kevin B. Donnelly, Elodie Drevon-Gaillot, Stephen K. Durham, Jeffery A. Engelhardt, Daniela Ennulat, James Fikes, John Reginald Foster, Kathleen Funk, Sibylle Gröters, Magali R. Guffroy, Silvia Guionaud, Katherine Hammerman, Carole Harbison, Claudia Harper, Christopher Hurst, Evan B. Janovitz, Kevin Keane, Stephanie Klein, Rebecca Kohnken, Michael W. Leach, Xiantang Li, René Meisner, Keith Nelson, Thomas Nolte, Arun R. Pandiri, Jonathan A. Phillips, Colin G. Rousseaux, Daniel G. Rudmann, Keegan C. Rudmann, Aaron M. Sargeant, JoAnn C.L. Schuh, A. Eric Schultze, Rani S. Sellers, James A. Swenberg, Eric Tien, John L. Vahle, Lyn M. Wancket, and Charles E. Wood

Published
2023

3. Contributors

Author

E. Terence Adams, Rick Adler, Carl L. Alden, Phillip M. Bartholomew, Joydeep Basu, Val R. Beasley, Brian R. Berridge, Timothy A. Bertram, Hyo-eun Bhang, Hugh E. Black, Brad Bolon, Gary A. Boorman, Denise I. Bounous, Rogely Waite Boyce, William M. Bracken, Amy E. Brix, Danielle Brown, Mark T. Butt, Glenn H. Cantor, Bruce D. Car, Vincent Castranova, Russell C. Cattley, Curtis Chan, Robert E. Chapin, Samuel M. Cohen, Steve Colegate, Daniel Cook, Paul S. Cooke, Torrie A. Crabbs, Dianne M. Creasy, James W. Crissman, John M. Cullen, Dimitry M. Danilenko, Barbara Davis, Myrtle A. Davis, T. Zane Davis, Ronald A. DeLellis, Nancy D. Denslow, Kelly L. Diegel, David C. Dorman, Richard R. Dubielzig, Stephen K. Durham, Sandy Eldridge, Susan A. Elmore, Jeffrey I. Everitt, Suzanne Fenton, Duncan C. Ferguson, Reuel Field, George L. Foley, William R. Foster, Jerry D. Frantz, Kathy Gabrielson, Shayne C. Gad, Elizabeth J. Galbreath, Dale R. Gardner, Robert H. Garman, Santokh Gill, Peter Glerup, Dale L. Goad, Mary Elizabeth Pecquet Goad, Nanna Grand, Benjamin T. Green, Kathryn E. Gropp, Hans Jørgen G. Gundersen, Diane Gunson, Ramesh C. Gupta, Sharon M. Gwaltney-Brant, Jeffery O. Hall, Wendy Halpern, Gordon C. Hard, Jerry F. Hardisty, Jack R. Harkema, Philip W. Harvey, Wanda M. Haschek, Kathleen Heinz-Taheny, Ronald A. Herbert, Eugene Herman, Mark Hoenerhoff, Ann Hubbs, David Hutto, Evan B. Janovitz, Kanwar Nasir M. Khan, Kevin P. Keenan, Roy L. Kerlin, John M. Kreeger, Kannan Krishnan, C. Frieke Kuper, Stephen T. Lee, Lois D. Lehman-McKeeman, Xiantang Li, Eric D. Lombardini, Calvert Louden, John W. Ludlow, David E. Malarkey, Peter C. Mann, Robert R. Maronpot, Kevin S. McDorman, Mark A. Melanson, Robert Mercer, Rosanna Mirabile, Ronald W. Moch, James P. Morrison, Daniel Morton, Laura Dill Morton, Sureshkumar Muthupalani, Kristen J. Nikula, Ricardo Ochoa, Michelle E. Pacheco-Thompson, Olga M. Pulido, Kip E. Panter, George A. Parker, Dale W. Porter, Douglas Reid Patterson, James A. Pfister, Carl A. Pinkert, Lila Ramaiah, Deepa B. Rao, Donald G. Robertson, Jennifer Rojko, Thomas J. Rosol, Colin G. Rousseaux, Daniel G. Rudmann, Christine Ruehl-Fehlert, Linda Sargent, Christina M. Satterwhite, Kenneth A. Schafer, Philip F. Solter, Robert C. Sills, Liz Simon, Mikala Skydsgaard, Graham S. Smith, Krishnan Sriram, Bryan L. Stegelmeier, John M. Sullivan, Catherine Sutcliffe, James A. Swenberg, Polina Sysa-Shah, Leandro Teixeira, Noriko Tsuchiya, John L. Vahle, John F. Van Vleet, Aurore Varela, Kenneth A. Voss, Robin M. Walker, Matthew A. Wallig, Gail L. Walter, Kevin D. Welch, Paul White, Christopher T. Winkelmann, Zbigniew W. Wojcinski, and Jeffrey C. Wolf

Published
2013

4. Risk Assessment

Author

James A. Swenberg and Stephen K. Durham

Subjects
Risk analysis (engineering), Process (engineering), Computer science, Human exposure, Adverse health effect, Mechanism based, Hazard analysis, Risk assessment, Variety (cybernetics), Exposure assessment
Abstract

Risk assessment is the systematic analysis of scientific data to characterize potential adverse health effects resulting from human exposure to hazardous agents or situations. Classical risk assessment is composed of four major components, including hazard identification, dose–response evaluation, exposure assessment, and risk characterization. This assessment relies on a wide variety of data sources of both a qualitative and a quantitative nature. Classical default-based risk assessment is evolving into a science-based risk assessment process that more fully utilizes mechanistic data. The integrative analysis of toxicogenomic-derived data into this process has favorably impacted the risk assessment landscape.

Published
2013

5. Risk AssessmentThe Changing Paradigm

Author

James A. Swenberg and Stephen K. Durham

Subjects
Risk perception, Engineering, Risk analysis (engineering), business.industry, Process (engineering), Management science, Risk analysis (business), Risk management tools, Factor analysis of information risk, Risk assessment, business, Hazard, Risk management
Abstract

This chapter discusses the changing paradigm of the risk assessment. Veterinary pathologists and toxicologists participate in the risk assessment process on a daily basis. The pathologist, together with the input from colleagues in toxicology, initially identifies the potential adverse effects of chemicals and drugs in laboratory animals, defines the dose response of the effects, and then determines whether they are likely to express themselves in humans. In order to ascertain an accurate conclusion in the risk assessment process, broad scientific knowledge with biologically based mechanistic information is required. Mechanism helps to determine whether the hazard develops in humans or not; gives quantitative information to suggest that risk is more or less likely to occur; and helps identify subpopulations that are at greater or lesser risk. Thus, there is a critical need for a scientific understanding of mechanism to reduce the extent of uncertainty associated with the assessment of risk. Risk management is the decision-making process that formulates policy actions designed to reduce the probability that the hazard will be expressed. Different skill sets are required for risk assessment and risk management. In addition to evaluating risk estimates, risk managers must also consider statutory, economic, social, and political factors. The perception of risk and its impact varies greatly among societies.

Published
2002

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