1. Stromal myofibroblasts in squamous cell carcinoma of the tongue in young patients - a multicenter collaborative study.
- Author
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Fonseca FP, Coletta RD, Azevedo MB, Prado Ribeiro AC, Pires Soubhia AM, Miyahara GI, Carlos R, Farthing P, Hunter KD, Speight PM, Vargas PA, Almeida OP, Lopes MA, and Santos-Silva AR
- Subjects
- Adolescent, Adult, Aged, Female, Humans, Immunoenzyme Techniques, Male, Middle Aged, Risk Factors, Carcinoma, Squamous Cell pathology, Myofibroblasts pathology, Tongue Neoplasms pathology
- Abstract
Objective: The purpose of this study was to evaluate the presence of myofibroblasts, frequently associated with a more aggressive neoplastic behavior, in oral tongue squamous cell carcinoma (TSCC) of young patients and to compare with the distribution observed in older patients., Study Design: Tumor samples from 29 patients younger than 40 years old affected by TSCC were retrieved and investigated for the presence of stromal myofibroblasts by immunohistochemical reactions against α smooth muscle actin, and the results obtained were compared to TSCC cases affecting older patients., Results: No positive reaction could be found in the stromal areas devoid of neoplastic tissue, whereas myofibroblasts were present in 58.6% of the lesions in young patients and in 75.9% of the older ones. No significant difference was found when comparing the invasive front and the overall stroma of both groups, and no correlation could be obtained with stromal α smooth muscle actin expression, higher tumor grades or clinical stage (P > .05)., Conclusion: There was no significant difference between the presence of stromal myofibroblasts of TSCC affecting young and old individuals., (Copyright © 2014 Elsevier Inc. All rights reserved.)
- Published
- 2014
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