1. Isolation of four new monoterpenes from Ailanthus altissima (mill.) Swingle and their enzyme inhibitory effects.
- Author
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Song Q, Duan ZK, Tan YN, Gao ZH, Liu D, Hao JL, Lin B, Huang XX, and Song SJ
- Subjects
- Molecular Structure, Cholinesterase Inhibitors isolation & purification, Cholinesterase Inhibitors pharmacology, Cholinesterase Inhibitors chemistry, Monophenol Monooxygenase antagonists & inhibitors, Acetylcholinesterase metabolism, Butyrylcholinesterase metabolism, Ailanthus chemistry, Monoterpenes isolation & purification, Monoterpenes pharmacology, Molecular Docking Simulation, Phytochemicals isolation & purification, Phytochemicals pharmacology, Plant Leaves chemistry
- Abstract
A phytochemical study of the ethanol extract from Ailanthus altissima (Mill.) Swingle leaves resulted in the isolation of four new monoterpenoids (1-3, 5). The structures were elucidated using HRESIMS data, NMR spectroscopic data, quantum chemical calculations for NMR and ECD, and custom DP4+ probability analysis. Additionally, the absolute configuration of sugar was determined by acid hydrolysis. Compounds 1-4 are cyclogeraniane monocyclic monoterpenes, while compound 5 contains an acyclic mycrane monoterpenes skeleton. Anti-tyrosinase, anti-acetylcholinesterase, and anti-butyrylcholinesterase activities were tested. Compound 1 showed notable anti-acetylcholinesterase activity, and compound 3 exhibited significant inhibitory effects on anti-tyrosinase activity. Furthermore, the potential binding sites of compounds 1 and 3 were predicted by molecular docking., Competing Interests: Declaration of competing interest Qi Song, Zhi-Kang Duan, Ya-Nuo Tan, Zhi-Heng Gao, Dai Liu, Jin-Le Hao, Bin Lin, Xiao-Xiao Huang, and Shao-Jiang Song declare that they have no conflict of interest., (Copyright © 2024 Elsevier B.V. All rights reserved.)
- Published
- 2024
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