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20 results on '"Smith, G.D."'

1. Measurement of the beam spin asymmetry of e→p→e′p′η in the deep-inelastic regime with CLAS

Author

Zhao, B., Kim, A., Joo, K., Bedlinskiy, I., Kim, W., Kubarovsky, V., Ungaro, M., Adhikari, S., Akbar, Z., Angelini, G., Avakian, H., Ball, J., Baltzell, N.A., Barion, L., Bashkanov, M., Battaglieri, M., Batourine, V., Biselli, A.S., Boiarinov, S., Briscoe, W.J., Brooks, W.K., Burkert, V.D., Carman, D.S., Celentano, A., Chatagnon, P., Chetry, T., Ciullo, G., Clark, L., Clary, B.A., Cole, P.L., Contalbrigo, M., Crede, V., D'Angelo, A., Dashyan, N., De Vita, R., De Sanctis, E., Defurne, M., Deur, A., Diehl, S., Djalali, C., Dupre, R., Egiyan, H., Ehrhart, M., El Alaoui, A., El Fassi, L., Eugenio, P., Filippi, A., Forest, T.A., Gavalian, G., Ghandilyan, Y., Gilfoyle, G.P., Girod, F.X., Golovatch, E., Gothe, R.W., Griffioen, K.A., Guidal, M., Guo, L., Hafidi, K., Hakobyan, H., Harrison, N., Hattawy, M., Heddle, D., Hicks, K., Holtrop, M., Ilieva, Y., Ireland, D.G., Ishkhanov, B.S., Isupov, E.L., Jenkins, D., Jo, H.S., Johnston, S., Kabir, M.L., Keller, D., Khachatryan, G., Khachatryan, M., Khandaker, M., Klein, A., Klein, F.J., Kuhn, S.E., Kuleshov, S.V., Lanza, L., Lenisa, P., Livingston, K., MacGregor, I.J.D., Marchand, D., Markov, N., McKinnon, B., Meyer, C.A., Meziani, Z.E., Mirazita, M., Mokeev, V., Montgomery, R.A., Munoz Camacho, C., Nadel-Turonski, P., Niccolai, S., Niculescu, G., Osipenko, M., Ostrovidov, A.I., Paolone, M., Paremuzyan, R., Park, K., Pogorelko, O., Price, J.W., Prok, Y., Protopopescu, D., Ripani, M., Rizzo, A., Rosner, G., Rossi, P., Sabatié, F., Salgado, C., Schumacher, R.A., Sharabian, Y.G., Skorodumina, Iu., Smith, G.D., Sokhan, D., Sparveris, N., Stepanyan, S., Strakovsky, I.I., Strauch, S., Taiuti, M., Tan, J.A., Voskanyan, H., Voutier, E., Wang, R., Wei, X., Wood, M.H., Zachariou, N., Zhang, J., and Zhao, Z.W.

Subjects
Nucleon structure, Deeply Virtual Meson Production, Chiral-odd generalized parton distributions, High Energy Physics::Phenomenology, Chiral-odd generalized parton distributions, CLAS collaboration, Deeply Virtual Meson Production, Nucleon structure, Socio-culturale, CLAS collaboration, High Energy Physics::Experiment, Nuclear Experiment, lcsh:Physics, lcsh:QC1-999, Settore FIS/04 - Fisica Nucleare e Subnucleare
Abstract

The beam spin asymmetry of the exclusive pseudoscalar channel e→p→e′p′η was measured for the first time in the deep-inelastic regime (W>2 GeV/c2 and Q2>1 GeV2/c2) using a longitudinally polarized 5.78 GeV electron beam at Jefferson Lab with the CEBAF Large Acceptance Spectrometer. The data were accumulated in 144 four-dimensional bins of Q2, xB, −t and ϕ over a wide kinematic range, where ϕ is the azimuthal angle between the lepton and hadron scattering planes, The measured azimuthal dependence with large amplitudes of the sin⁡ϕ moments is a clear indication of a substantial contribution to the polarized cross-section from transversely polarized virtual photons. In the framework of generalized parton distributions (GPDs) this contribution is expressed via longitudinal-transverse interference between chiral-even and chiral-odd GPDs. The experimental results are compared to the existing theoretical models demonstrating the sensitivity to the product of chiral-odd and chiral-even GPDs and provide new constraints to the existing GPD parameterizations. Keywords: Nucleon structure, CLAS collaboration, Deeply Virtual Meson Production, Chiral-odd generalized parton distributions

Published
2019

2. Measurement of the beam spin asymmetry of in the deep-inelastic regime with CLAS

Author

Zhao, B., Kim, A., Joo, K., Bedlinskiy, I., Kim, W., Kubarovsky, V., Ungaro, M., Adhikari, S., Akbar, Z., Angelini, G., Avakian, H., Ball, J., Baltzell, N.A., Barion, L., Bashkanov, M., Battaglieri, M., Batourine, V., Biselli, A.S., Boiarinov, S., Briscoe, W.J., Brooks, W.K., Burkert, V.D., Carman, D.S., Celentano, A., Chatagnon, P., Chetry, T., Ciullo, G., Clark, L., Clary, B.A., Cole, P.L., Contalbrigo, M., Crede, V., D'Angelo, A., Dashyan, N., De Vita, R., De Sanctis, E., Defurne, M., Deur, A., Diehl, S., Djalali, C., Dupre, R., Egiyan, H., Ehrhart, M., El Alaoui, A., El Fassi, L., Eugenio, P., Filippi, A., Forest, T.A., Gavalian, G., Ghandilyan, Y., Gilfoyle, G.P., Girod, F.X., Golovatch, E., Gothe, R.W., Griffioen, K.A., Guidal, M., Guo, L., Hafidi, K., Hakobyan, H., Harrison, N., Hattawy, M., Heddle, D., Hicks, K., Holtrop, M., Ilieva, Y., Ireland, D.G., Ishkhanov, B.S., Isupov, E.L., Jenkins, D., Jo, H.S., Johnston, S., Kabir, M.L., Keller, D., Khachatryan, G., Khachatryan, M., Khandaker, M., Klein, A., Klein, F.J., Kuhn, S.E., Kuleshov, S.V., Lanza, L., Lenisa, P., Livingston, K., MacGregor, I.J.D., Marchand, D., Markov, N., McKinnon, B., Meyer, C.A., Meziani, Z.E., Mirazita, M., Mokeev, V., Montgomery, R.A., Munoz Camacho, C., Nadel-Turonski, P., Niccolai, S., Niculescu, G., Osipenko, M., Ostrovidov, A.I., Paolone, M., Paremuzyan, R., Park, K., Pogorelko, O., Price, J.W., Prok, Y., Protopopescu, D., Ripani, M., Rizzo, A., Rosner, G., Rossi, P., Sabatié, F., Salgado, C., Schumacher, R.A., Sharabian, Y.G., Skorodumina, Iu., Smith, G.D., Sokhan, D., Sparveris, N., Stepanyan, S., Strakovsky, I.I., Strauch, S., Taiuti, M., Tan, J.A., Voskanyan, H., Voutier, E., Wang, R., Wei, X., Wood, M.H., Zachariou, N., Zhang, J., and Zhao, Z.W.

Abstract

The beam spin asymmetry of the exclusive pseudoscalar channel e→p→e′p′η was measured for the first time in the deep-inelastic regime (W>2 GeV/c2 and Q2>1 GeV2/c2) using a longitudinally polarized 5.78 GeV electron beam at Jefferson Lab with the CEBAF Large Acceptance Spectrometer. The data were accumulated in 144 four-dimensional bins of Q2, xB, −t and ϕ over a wide kinematic range, where ϕ is the azimuthal angle between the lepton and hadron scattering planes, The measured azimuthal dependence with large amplitudes of the sin⁡ϕ moments is a clear indication of a substantial contribution to the polarized cross-section from transversely polarized virtual photons. In the framework of generalized parton distributions (GPDs) this contribution is expressed via longitudinal-transverse interference between chiral-even and chiral-odd GPDs. The experimental results are compared to the existing theoretical models demonstrating the sensitivity to the product of chiral-odd and chiral-even GPDs and provide new constraints to the existing GPD parameterizations.

Published
2019

3. First results on nucleon resonance photocouplings from the γp → π+π−p reaction

Author

Golovatch, E., Burkert, V.D., Carman, D.S., Gothe, R.W., Hicks, K., Ishkhanov, B.S., Mokeev, V.I., Pasyuk, E., Adhikari, S., Akbar, Z., Amaryan, M.J., Avakian, H., Ball, J., Barion, L., Bashkanov, M., Battaglieri, M., Bedlinskiy, I., Biselli, A.S., Boiarinov, S., Briscoe, W.J., Cao, F., Celentano, A., Chatagnon, P., Chetry, T., Ciullo, G., Clark, L., Clary, B.A., Cole, P.L., Contalbrigo, M., Crede, V., D'Angelo, A., Dashyan, N., De Vita, R., De Sanctis, E., Defurne, M., Deur, A., Diehl, S., Djalali, C., Dugger, M., Dupre, R., Egiyan, H., Ehrhart, M., El Alaoui, A., El Fassi, L., Elouadrhiri, L., Eugenio, P., Fedotov, G., Fersch, R., Filippi, A., Ghandilyan, Y., Gilfoyle, G.P., Giovanetti, K.L., Girod, F.X., Glazier, D.I., Griffioen, K.A., Guidal, M., Guo, L., Hafidi, K., Hakobyan, H., Harrison, N., Hattawy, M., Heddle, D., Holtrop, M., Ilieva, Y., Ireland, D.G., Isupov, E.L., Jenkins, D., Jo, H.S., Johnston, S., Joo, K., Kabir, M.L., Keller, D., Khachatryan, G., Khachatryan, M., Khandaker, M., Kim, W., Klein, A., Klein, F.J., Kubarovsky, V., Lanza, L., Lenisa, P., Livingston, K., MacGregor, I.J.D., Marchand, D., Markov, N., McKinnon, B., Meyer, C.A., Montgomery, R.A., Movsisyan, A., Munoz Camacho, C., Nadel-Turonski, P., Niccolai, S., Niculescu, G., Osipenko, M., Ostrovidov, A.I., Paolone, M., Paremuzyan, R., Park, K., Pogorelko, O., Price, J.W., Prok, Y., Protopopescu, D., Ripani, M., Riser, D., Rizzo, A., Rosner, G., Sabatié, F., Salgado, C., Schumacher, R.A., Sharabian, Y.G., Skorodumina, Iu., Smith, G.D., Sober, D.I., Sokhan, D., Sparveris, N., Strakovsky, I.I., Strauch, S., Taiuti, M., Tan, J.A., Tyler, N., Ungaro, M., Voskanyan, H., Voutier, E., Wang, R., Wei, X., Wood, M.H., Zachariou, N., Zhang, J., and Zhao, Z.W.

Abstract

No abstract available.

Published
2019

5. Differential cross section for γd → ωd using CLAS at Jefferson Lab

Author

Chetry, T., Hicks, K., Compton, N., Sargsian, M., Adhikari, S., Ball, J., Balossino, I., Barion, L., Battaglieri, M., Batourine, V., Bedlinskiy, I., Biselli, A.S., Boiarinov, S., Briscoe, W.J., Brooks, W.K., Burkert, V.D., Carman, D.S., Celentano, A., Charles, G., Ciullo, G., Clark, L., Clary, Brandon A., Cole, P.L., Contalbrigo, M., Crede, V., D'Angelo, A., Dashyan, N., De Vita, R., De Sanctis, E., Deur, A., Djalali, C., Dupre, R., El Alaoui, A., El Fassi, L., Eugenio, P., Fedotov, G., Fersch, R., Filippi, A., Gavalian, G., Ghandilyan, Y., Giovanetti, K.L., Girod, F.X., Golovatch, E., Gothe, R.W., Griffioen, K.A., Guo, L., Hafidi, K., Harrison, N., Hattawy, M., Holtrop, M., Ilieva, Y., Ireland, D.G., Ishkhanov, B.S., Isupov, E.L., Jenkins, D., Johnston, S., Kabir, M.L., Keller, D., Khachatryan, G., Khachatryan, M., Khandaker, M., Kim, A., Kim, W., Klein, F.J., Kubarovsky, V., Lanza, L., Lenisa, P., Livingston, K., MacGregor, I.J.D., Markov, N., McKinnon, B., Mokeev, V., Movsisyan, A., Munoz Camacho, C., Nadel-Turonski, P., Niccolai, S., Niculescu, G., Osipenko, M., Ostrovidov, A.I., Paolone, M., Paremuzyan, R., Park, K., Pasyuk, E., Phelps, W., Pogorelko, O., Price, J.W., Prok, Y., Ripani, M., Riser, D., Ritchie, B.G., Rizzo, A., Rosner, G., Salgado, C., Schumacher, R.A., Skorodumina, Iu., Smith, G.D., Sober, D.I., Sokhan, D., Sparveris, N., Stepanyan, S., Strakovsky, I.I., Strauch, S., Taiuti, M., Tan, J.A., Ungaro, M., Voskanyan, H., Voutier, E., Weinstein, L.B., Wood, M.H., Zachariou, N., Zhang, J., and Zhao, Z.W.

Abstract

The cross section for coherent ω-meson photoproduction off the deuteron has been measured for the\ud first time as a function of the momentum transfer t = (Pγ − Pω)2 and photon energy Eγ using the CLAS\ud detector at the Thomas Jefferson National Accelerator Facility. The cross sections are measured in the\ud energy range 1.4 < Eγ < 3.4 GeV. A model based on ω − N rescattering is consistent with the data at\ud low and intermediate momentum transfer, |t|. For 2.8 < Eγ < 3.4 GeV, the total cross-section of ω − N\ud scattering, based on fits within the framework of the Vector Meson Dominance model, is in the range of\ud 30–40 mb.

Published
2018

6. Semi-inclusive target and beam-target asymmetries from 6 GeV electron scattering with CLAS

Author

Jawalkar, S., Koirala, S., Avakian, H., Bosted, P., Griffioen, K.A., Keith, C., Kuhn, S.E., Adhikari, K.P., Adhikari, S., Adikaram, D., Akbar, Z., Amaryan, M.J., Anefalos Pereira, S., Ball, J., Baltzell, N.A., Battaglieri, M., Batourine, V., Bedlinskiy, I., Biselli, A.S., Boiarinov, S., Briscoe, W.J., Brock, J., Brooks, W.K., Bültmann, S., Burkert, V.D., Cao, Frank Thanh, Carlin, C., Carman, D.S., Celentano, A., Charles, G., Chetry, T., Ciullo, G., Clark, L., Colaneri, L., Cole, P.L., Contalbrigo, M., Cortes, O., Crede, V., D'Angelo, A., Dashyan, N., De Vita, R., De Sanctis, E., Defurne, M., Deur, A., Djalali, C., Ddoge, G., Dupre, R., Egiyan, H., El Alaoui, A., El Fassi, L., Elouadrhiri, L., Eugenio, P., Fedotov, G., Fegan, S., Fersch, R., Filippi, A., Fleming, J.A., Forest, T.A., Fradi, A., Garçon, M., Ghandilyan, Y., Gilfoyle, G.P., Giovanetti, K.L., Girod, F.X., Gleason, C., Gohn, W., Golovatch, E., Gothe, R.W., Guidal, M., Guler, N., Guo, L., Hakobyan, H., Hanretty, C., Harrison, N., Hattawy, M., Heddle, D., Hicks, K., Hollis, G., Holtrop, M., Hughes, S.M., Ilieva, Y., Ireland, D.G., Ishkhanov, B.S., Isupov, E.L., Jenkins, D., Jiang, H., Joo, K., Joosten, S., Keller, D., Khachatryan, G., Khachatryan, M., Khandaker, M., Kim, A., Kim, W., Klein, A., Klein, F.J., Kubarovsky, V., Kuleshov, S.V., Lanza, L., Lenisa, P., Livingston, K., Lu, H.Y., MacGregor, I.J.D., Markov, N., Mayer, M., McCracken, M.E., McKinnon, B., Meyer, C.A., Mineeva, T., Mirazita, M., Mokeev, V., Montgomery, R.A., Movsisyan, A., Munoz Camacho, C., Nadel-Turonski, P., Net, L.A., Niccolai, S., Niculescu, G., Niculescu, I., Osipenko, M., Ostrovidov, A.I., Paremuzyan, R., Park, K., Pasyuk, E., Phelps, E., Phelps, W., Pierce, J., Pisano, S., Pogorelko, O., Price, J.W., Prok, Y., Protopopescu, D., Raue, B.A., Ripani, M., Riser, D., Rizzo, A., Rosner, G., Rossi, P., Sabatié, F., Salgado, C., Schumacher, R.A., Seder, E., Sharabian, Y.G., Simonyan, A., Skorodumina, Iu., Smith, G.D., Sober, D.I., Sokhan, D., Sparveris, N., Stankovic, I., Strauch, S., Taiuti, M., Ungaro, M., Voskanyan, H., Voutier, E., Walford, N.K., Watts, D.P., Wei, X., Weinstein, L.B., Wood, M.H., Zachariou, N., Zhang, J., and Zhao, Z.W.

Abstract

We present precision measurements of the target and beam-target spin asymmetries from neutral pion electroproduction in deep-inelastic scattering (DIS) using the CEBAF Large Acceptance Spectrometer (CLAS) at Jefferson Lab. We scattered 6-GeV, longitudinally polarized electrons off longitudinally polarized protons in a cryogenic $^{14}$NH$_{3}$ target, and extracted double and single target spin asymmetries for ep→e′π0X in multidimensional bins in four-momentum transfer (1.0

Published
2018

8. Photon beam asymmetry Σ in the reaction γ→p→pω for E γ = 1.152 to 1.876 GeV

Author

Collins, P., Ritchie, B.G., Dugger, M., Klein, F.J., Anisovich, A.V., Klempt, E., Nikonov, V.A., Sarantsev, A., Adhikari, K.P., Adhikari, S., Adikaram, D., Akbar, Z., Anefalos Pereira, S., Avakian, H., Ball, J., Baltzell, N.A., Bashkanov, M., Battaglieri, M., Batourine, V., Bedlinskiy, I., Biselli, A.S., Boiarinov, S., Briscoe, W.J., Brooks, W.K., Burkert, V.D., Cao, Frank Thanh, Cao, T., Carman, D.S., Celentano, A., Charles, G., Chetry, T., Ciullo, G., Clark, L., Cole, P.L., Contalbrigo, M., Cortes, O., Crede, V., Dashyan, N., De Vita, R., De Sanctis, E., Defurne, M., Deur, A., Djalali, C., Dupre, R., Egiyan, H., El Alaoui, A., El Fassi, L., Eugenio, P., Fedotov, G., Filippi, A., Fleming, J.A., Ghandilyan, Y., Gilfoyle, G.P., Giovanetti, K.L., Girod, F.X., Glazier, D.I., Gleason, C., Golovatch, E., Gothe, R.W., Griffioen, K.A., Guidal, M., Hafidi, K., Hakobyan, H., Hanretty, C., Harrison, N., Hattawy, M., Heddle, D., Hicks, K., Hollis, G., Holtrop, M., Hughes, S.M., Ilieva, Y., Ireland, D.G., Ishkhanov, B.S., Isupov, E.L., Jenkins, D., Jiang, H., Jo, H.S., Joosten, S., Keller, D., Khachatryan, G., Khachatryan, M., Khandaker, M., Kim, A., Kim, W., Klein, A., Kubarovsky, V., Kuleshov, S.V., Lanza, L., Lenisa, P., Livingston, K., MacGregor, I.J.D., Markov, N., McKinnon, B., Meyer, C.A., Meziani, Z.E., Mineeva, T., Mokeev, V., Montgomery, R.A., Movsisyan, A., Munevar, E., Munoz Camacho, C., Nadel-Turonski, P., Net, L.A., Niccolai, S., Niculescu, G., Niculescu, I., Osipenko, M., Ostrovidov, A.I., Paolone, M., Paremuzyan, R., Park, K., Pasyuk, E., Phelps, W., Pisano, S., Pogorelko, O., Price, J.W., Procureur, S., Prok, Y., Protopopescu, D., Raue, B.A., Ripani, M., Rizzo, A., Rosner, G., Sabatié, F., Salgado, C., Schumacher, R.A., Sharabian, Y.G., Simonyan, A., Skorodumina, Iu., Smith, G.D., Sober, D.I., Sokhan, D., Sparveris, N., Stankovic, I., Stepanyan, S., Strakovsky, I.I., Strauch, S., Taiuti, M., Ungaro, M., Voskanyan, H., Voutier, E., Walford, N.K., Watts, D.P., Wei, X., Wood, M.H., Zachariou, N., Zhang, J., and Zhao, Z.W.

Subjects
Nuclear Experiment
Abstract

Photon beam asymmetry Σ measurements for ω photoproduction in the reaction γ→p→ωp are reported for photon energies from 1.152 to 1.876 GeV. Data were taken using a linearly-polarized tagged photon beam, a cryogenic hydrogen target, and the CLAS spectrometer in Hall B at Jefferson Lab. The measurements obtained markedly increase the size of the database for this observable, extend coverage to higher energies, and resolve discrepancies in previously published data. Comparisons of these new results with predictions from a chiral-quark-based model and from a dynamical coupled-channels model indicate the importance of interferences between t -channel meson exchange and s - and u -channel contributions, underscoring sensitivity to the nucleon resonances included in those descriptions. Comparisons with the Bonn–Gatchina partial-wave analysis indicate the Σ data reported here help to fix the magnitudes of the interference terms between the leading amplitudes in that calculation (Pomeron exchange and the resonant portion of the JP=3/2+ partial wave), as well as the resonant portions of the smaller partial waves with JP=1/2− , 3/2− , and 5/2+ .

Published
2017

9. Strengthening mechanisms in an Al-Fe-Cr-Ti nano-quasicrystalline alloy and composites

Author

Engineering and Physical Sciences Research Council (UK), Pedrazzini, S., Galano, M., Audebert, F., Collins, D.M., Hofmann, F., Abbey, B., Korsunsky, A.M., Lieblich, Marcela, García Escorial, Asunción, Smith, G.D., Engineering and Physical Sciences Research Council (UK), Pedrazzini, S., Galano, M., Audebert, F., Collins, D.M., Hofmann, F., Abbey, B., Korsunsky, A.M., Lieblich, Marcela, García Escorial, Asunción, and Smith, G.D.

Abstract

We report a study of the structure-processing-property relationships in a high strength AlFeCrTi nano-quasicrystalline alloy and composites containing 10 and 20 vol% ductilising pure Al fibres. The superimposed contributions of several different strengthening mechanisms have been modelled analytically using data obtained from systematic characterisation of the monolithic alloy bar. An observed yield strength of 544 MPa has been substantiated from a combination of solid solution strengthening, work hardening, precipitation hardening and Hall-Petch grain size dependent effects. These materials have been shown by other authors in previous published work to be highly sensitive to the size distribution of particles in the powder from which they are made, and the subsequent thermomechanical processing conditions. The processing condition employed in this study provided micron-sized grains with a strong [111] preferential orientation along the extrusion direction and a bimodal size distribution of the icosahedral nano-quasicrystalline precipitates. Both were deemed to be a significant contributor to the high yield strength observed. The addition of pure Al fibres was found to decrease the yield strength linearly with increasing Al content, and to augment the ductility of the composites.

Published
2016

10. Sensitisation waves in a bidomain fire-diffuse-fire model of intracellular Ca²⁺ dynamics

Author

Thul, Ruediger, Coombes, Stephen, and Smith, G.D.

Abstract

We present a bidomain threshold model of intracellular calcium (Ca²⁺) dynamics in which, as suggested by recent experiments, the cytosolic threshold for Ca²⁺ liberation is modulated by the Ca²⁺ concentration in the releasing compartment. We explicitly construct stationary fronts and determine their stability using an Evans function approach. Our results show that a biologically motivated choice of a dynamic threshold, as opposed to a constant threshold, can pin stationary fronts that would otherwise be unstable. This illustrates a novel mechanism to stabilise pinned interfaces in continuous excitable systems. Our framework also allows us to compute travelling pulse solutions in closed form and systematically probe the wave speed as a function of physiologically important parameters. We find that the existence of travelling wave solutions depends on the time scale of the threshold dynamics, and that facilitating release by lowering the cytosolic threshold increases the wave speed. The construction of the Evans function for a travelling pulse shows that of the co-existing fast and slow solutions the slow one is always unstable.

Published
2009

11. List of Contributors

Author

Allen, B.L., primary, Arnold, R.W., additional, Bouma, J., additional, Drees, L.R., additional, Edmonds, R.L., additional, Fanning, D.S., additional, Hall, G.F., additional, Mackintosh, E.E., additional, Runge, E.C.A., additional, Smeck, N.E., additional, Smith, G.D., additional, Ugolini, F.C., additional, Wilding, L.P., additional, and Yaalon, D.H., additional

Published
1983
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16. Sensitisation waves in a bidomain fire-diffuse-fire model of intracellular Ca²⁺ dynamics

Author

Thul, Ruediger, Coombes, Stephen, Smith, G.D., Thul, Ruediger, Coombes, Stephen, and Smith, G.D.

Abstract

We present a bidomain threshold model of intracellular calcium (Ca²⁺) dynamics in which, as suggested by recent experiments, the cytosolic threshold for Ca²⁺ liberation is modulated by the Ca²⁺ concentration in the releasing compartment. We explicitly construct stationary fronts and determine their stability using an Evans function approach. Our results show that a biologically motivated choice of a dynamic threshold, as opposed to a constant threshold, can pin stationary fronts that would otherwise be unstable. This illustrates a novel mechanism to stabilise pinned interfaces in continuous excitable systems. Our framework also allows us to compute travelling pulse solutions in closed form and systematically probe the wave speed as a function of physiologically important parameters. We find that the existence of travelling wave solutions depends on the time scale of the threshold dynamics, and that facilitating release by lowering the cytosolic threshold increases the wave speed. The construction of the Evans function for a travelling pulse shows that of the co-existing fast and slow solutions the slow one is always unstable.

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17. Sensitisation waves in a bidomain fire-diffuse-fire model of intracellular Ca²⁺ dynamics

Author

Thul, Ruediger, Coombes, Stephen, Smith, G.D., Thul, Ruediger, Coombes, Stephen, and Smith, G.D.

Abstract

We present a bidomain threshold model of intracellular calcium (Ca²⁺) dynamics in which, as suggested by recent experiments, the cytosolic threshold for Ca²⁺ liberation is modulated by the Ca²⁺ concentration in the releasing compartment. We explicitly construct stationary fronts and determine their stability using an Evans function approach. Our results show that a biologically motivated choice of a dynamic threshold, as opposed to a constant threshold, can pin stationary fronts that would otherwise be unstable. This illustrates a novel mechanism to stabilise pinned interfaces in continuous excitable systems. Our framework also allows us to compute travelling pulse solutions in closed form and systematically probe the wave speed as a function of physiologically important parameters. We find that the existence of travelling wave solutions depends on the time scale of the threshold dynamics, and that facilitating release by lowering the cytosolic threshold increases the wave speed. The construction of the Evans function for a travelling pulse shows that of the co-existing fast and slow solutions the slow one is always unstable.

Full Text
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18. Sensitisation waves in a bidomain fire-diffuse-fire model of intracellular Ca²⁺ dynamics

Author

Thul, Ruediger, Coombes, Stephen, Smith, G.D., Thul, Ruediger, Coombes, Stephen, and Smith, G.D.

Abstract

We present a bidomain threshold model of intracellular calcium (Ca²⁺) dynamics in which, as suggested by recent experiments, the cytosolic threshold for Ca²⁺ liberation is modulated by the Ca²⁺ concentration in the releasing compartment. We explicitly construct stationary fronts and determine their stability using an Evans function approach. Our results show that a biologically motivated choice of a dynamic threshold, as opposed to a constant threshold, can pin stationary fronts that would otherwise be unstable. This illustrates a novel mechanism to stabilise pinned interfaces in continuous excitable systems. Our framework also allows us to compute travelling pulse solutions in closed form and systematically probe the wave speed as a function of physiologically important parameters. We find that the existence of travelling wave solutions depends on the time scale of the threshold dynamics, and that facilitating release by lowering the cytosolic threshold increases the wave speed. The construction of the Evans function for a travelling pulse shows that of the co-existing fast and slow solutions the slow one is always unstable.

Full Text
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19. Sensitisation waves in a bidomain fire-diffuse-fire model of intracellular Ca²⁺ dynamics

Author

Thul, Ruediger, Coombes, Stephen, Smith, G.D., Thul, Ruediger, Coombes, Stephen, and Smith, G.D.

Abstract

We present a bidomain threshold model of intracellular calcium (Ca²⁺) dynamics in which, as suggested by recent experiments, the cytosolic threshold for Ca²⁺ liberation is modulated by the Ca²⁺ concentration in the releasing compartment. We explicitly construct stationary fronts and determine their stability using an Evans function approach. Our results show that a biologically motivated choice of a dynamic threshold, as opposed to a constant threshold, can pin stationary fronts that would otherwise be unstable. This illustrates a novel mechanism to stabilise pinned interfaces in continuous excitable systems. Our framework also allows us to compute travelling pulse solutions in closed form and systematically probe the wave speed as a function of physiologically important parameters. We find that the existence of travelling wave solutions depends on the time scale of the threshold dynamics, and that facilitating release by lowering the cytosolic threshold increases the wave speed. The construction of the Evans function for a travelling pulse shows that of the co-existing fast and slow solutions the slow one is always unstable.

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20. Sensitisation waves in a bidomain fire-diffuse-fire model of intracellular Ca²⁺ dynamics

Author

Thul, Ruediger, Coombes, Stephen, Smith, G.D., Thul, Ruediger, Coombes, Stephen, and Smith, G.D.

Abstract

We present a bidomain threshold model of intracellular calcium (Ca²⁺) dynamics in which, as suggested by recent experiments, the cytosolic threshold for Ca²⁺ liberation is modulated by the Ca²⁺ concentration in the releasing compartment. We explicitly construct stationary fronts and determine their stability using an Evans function approach. Our results show that a biologically motivated choice of a dynamic threshold, as opposed to a constant threshold, can pin stationary fronts that would otherwise be unstable. This illustrates a novel mechanism to stabilise pinned interfaces in continuous excitable systems. Our framework also allows us to compute travelling pulse solutions in closed form and systematically probe the wave speed as a function of physiologically important parameters. We find that the existence of travelling wave solutions depends on the time scale of the threshold dynamics, and that facilitating release by lowering the cytosolic threshold increases the wave speed. The construction of the Evans function for a travelling pulse shows that of the co-existing fast and slow solutions the slow one is always unstable.

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