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Background: The burden of dyslipidemia in Bangladesh remains inadequately characterized., Objectives: To determine and describe the prevalence and pattern of dyslipidemia and its associated risk factors among an adult Bangladeshi population., Design: Population-based, cross-sectional study. Participants were adults living in all eight administrative divisions of Bangladesh. The total sample size was 7084 (53.1 % women, 46.9% urban residents). Primary outcome measures were triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and the use of lipid lowering medication. In addition, control of LDL-C and control of non high-density lipoprotein cholesterol (non-HDL-C) were investigated., Results: The overall dyslipidemia prevalence was 76.7%, with 35.7% showing a high TG level, 18.5% showing a high LDL-C level, 63.8% showing a low HDL-C level, and 7.2% of the participants showing all three lipid abnormalities. Sylhet division had the highest prevalence (83.8%) of overall dyslipidemia, while Rangpur had the lowest prevalence (69.3%). The control of LDL-C (<50 mg/dL) and non-HDL-C (<80 mg/dL) among adults with a previous history of atherosclerotic cardiovascular diseases (ASCVD) were 5.1% and 6.9% respectively. The regression models showed that male sex and age 45-59 years were significant predictors of overall dyslipidemia. Both smokers and smokeless tobacco users were significant factors for overall dyslipidemia and high TG. A high waist-hip ratio was associated with overall dyslipidemia and all other subtypes of dyslipidemia., Conclusion: The high prevalence of dyslipidemia in Bangladesh necessitates lifestyle interventions to prevent and control this cardiovascular risk factor., Competing Interests: Declaration of Competing Interest The authors declare there is no conflict of interests., (Copyright © 2023. Published by Elsevier Inc.)

Medicinal importance of the sulfonylhydrazones is well-evident owing to their binding ability with zinc containing metalloenzymes. In the present study, we have synthesized different series of sulfonylhydrazones by using facile synthetic methods in good to excellent yield. All the successfully prepared sulfonylhydrazones were screened for ectonucleotidase (ALP & e5'NT) inhibitory activity. Among the chromen-2-one scaffold based sulfonylhydrazones, the compounds 7 was found to be most potent inhibitor for h-TNAP (human tissue non-specific alkaline phosphatase) and h-IAP (human intestinal alkaline phosphatase) with IC 50 values of 1.02 ± 0.13 and 0.32 ± 0.0 3 µM respectively, compared with levamisole (IC 50  = 25.2 ± 1.90 µM for h-TNAP) and l-phenylalanine (IC 50  = 100 ± 3.00 µM for h-IAP) as standards. Further, the chromen-2-one based molecule 5a showed excellent activity against h-ecto 5'-NT (human ecto-5'-nucleotidase) with IC 50 value of 0.29 ± 0.004 µM compared to standard, sulfamic acid (IC 50  = 42.1 ± 7.8 µM). However, among the series of phenyl ring based sulfonylhydrazones, compound 9d was found to be most potent against h-TNAP and h-IAP with IC 50 values of 0.85 ± 0.08 and 0.52 ± 0.03 µM, respectively. Moreover, in silico studies were also carried to demonstrate their putative binding with the target enzymes. The potent compounds 5a, 7, and 9d against different ectonucleotidases (h-ecto 5'-NT, h-TNAP, h-IAP) could potentially serve as lead for the development of new therapeutic agents., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2020 Elsevier Inc. All rights reserved.)

O-Carboxymethyl chitosan (OCMC) Schiff's base was utilized for a new class of organic-inorganic hybrid material by grafting it on nano-silica-silane and further metallated with Cu (II). Here (3-Aminopropyl) triethoxysilane (APTES) was used as a linker and 2-hydroxy-1-naphthaldehyde (HN) for Schiff's base formation. The hybrid was characterized by FTIR, TGA, powder XRD, SEM, CHN, DLS, ICP-AES, diffuse reflectance UV-vis and EDX spectroscopic techniques. Magnetization measurements were carried out by VSM at room temperature. This study explored the possible synergic effect of unique properties of carboxymethyl chitosan, Schiff's base Cu (II) complex and nano-silica towards antibacterial activity and in dye degradation studies. The antibacterial performance of nano-hybrid material was examined against both Gram-positive (Escherichia coli) and Gram-negative (Bacillus subtilis) bacteria. The catalytic activity of the hybrid was tested for degradation of reactive black 5 (RB5) through advanced oxidation processes using H 2 O 2 as oxidant. The results show a high dye degradation efficiency of 93% in 130min by the hybrid catalyst with reusability. As per published reports, Chitosan-Schiff's bases show strong antimicrobial activity and their Cu complexes exhibit good catalytic and anticancer activities. Therefore, it is expected that the new organic-inorganic hybrid would be highly applicable in environmental as well as biomedical fields., (Copyright © 2017 Elsevier B.V. All rights reserved.)

Thioureas are exceptionally versatile building blocks towards the synthesis of wide variety of heterocyclic systems, which also possess extensive range of pharmacological activities. The substituted benzoic acids were converted into corresponding acid chlorides, these acid chlorides were then treated with potassium thiocyanate in acetone and then the reaction mixture was refluxed for 1-2h afford ethyl 4-(3-benzoylthioureido)benzoates thioureas in good yields. All the newly synthesized compounds were evaluated for their urease inhibitory activities and were found to be potent inhibitors of urease enzyme. Compounds 1f and 1g were identified as the most potent urease inhibitors (IC50 0.21 and 0.13 μM, respectively), and was 100-fold more potent than the standard inhibitors. Further molecular docking studies were carried out using the crystal structure of urease to find out the binding mode of the inhibitors with the enzyme., (Copyright © 2013 Elsevier Inc. All rights reserved.)