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Your search keyword '"Simon P. Kigozi"' showing total 2 results
Start Over Author "Simon P. Kigozi" Publisher elsevier
2 results on '"Simon P. Kigozi"'

1. LLIN evaluation in Uganda project (LLINEUP): The fabric integrity, chemical content and bioefficacy of long-lasting insecticidal nets treated with and without piperonyl butoxide across two years of operational use in Uganda

Author

Frank Mechan, Agaba Katureebe, Violet Tuhaise, Martin Mugote, Ambrose Oruni, Ismail Onyige, Kawesa Bumali, Jonathan Thornton, Kilama Maxwell, Mary Kyohere, Moses R. Kamya, Peter Mutungi, Simon P. Kigozi, Adoke Yeka, Jimmy Opigo, Catherine Maiteki-Sebuguzi, Samuel Gonahasa, Janet Hemingway, Grant Dorsey, Lisa J. Reimer, Sarah G. Staedke, Martin J. Donnelly, and Amy Lynd

Subjects
LLIN, Malaria, Durability, Insecticide, Bioefficacy, Piperonyl butoxide, Infectious and parasitic diseases, RC109-216
Abstract

Long-lasting insecticidal nets (LLINs) supplemented with the synergist piperonyl butoxide have been developed in response to growing pyrethroid resistance; however, their durability in the field remains poorly described. A pragmatic cluster-randomised trial was embedded into Ugandaʼs 2017–2018 LLIN distribution to compare the durability of LLINs with and without PBO. A total of 104 clusters (health sub-districts) were included with each receiving one of four LLIN products, two with pyrethroid + PBO (Olyset Plus and PermaNet 3.0) and two pyrethroid-only (Olyset Net and PermaNet 2.0). Nets were sampled at baseline, 12 and 25 months post-distribution to assess physical condition, chemical content, and bioefficacy. Physical condition was quantified using proportionate Hole Index and chemical content measured using high-performance liquid chromatography. Bioefficacy was assessed with three-minute World Health Organisation (WHO) Cone and Wireball assays using pyrethroid-resistant Anopheles gambiae, with 1-h knockdown and 24-h mortality recorded. There was no difference in physical durability between LLIN products assessed (P = 0.644). The pyrethroid content of all products remained relatively stable across time-points but PBO content declined by 55% (P

Published
2022
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2. Assessment of community-level effects of intermittent preventive treatment for malaria in schoolchildren in Jinja, Uganda (START-IPT trial): a cluster-randomised trial

Author

Sarah G Staedke, ProfPhD, Catherine Maiteki-Sebuguzi, MSc, Andrea M Rehman, PhD, Simon P Kigozi, MSc, Samuel Gonahasa, MBChB, Jaffer Okiring, MSc, Steve W Lindsay, ProfPhD, Moses R Kamya, ProfPhD, Clare I R Chandler, PhD, Grant Dorsey, ProfPhD, and Chris Drakeley, ProfPhD

Subjects
lcsh:Public aspects of medicine, parasitic diseases, lcsh:RA1-1270
Abstract

Summary: Background: Intermittent preventive treatment (IPT) is a well established malaria control intervention. Evidence that delivering IPT to schoolchildren could provide community-level benefits is limited. We did a cluster-randomised controlled trial to assess the effect of IPT of primary schoolchildren with dihydroartemisinin-piperaquine (DP) on indicators of malaria transmission in the community, in Jinja, Uganda. Methods: We included 84 clusters, each comprising one primary school and the 100 closest available households. The clusters were randomly assigned 1:1 to receive IPT with DP or standard care (control) by restricted randomisation to ensure balance by geography and school type. Children in intervention schools received IPT monthly for up to six rounds (June to December, 2014). We did cross-sectional community surveys in randomly selected households at baseline and in January to April, 2015, during which we measured participants' temperatures and obtained finger-prick blood smears for measurement of parasite prevalence by microscopy. We also did entomological surveys 1 night per month in households from 20 randomly selected IPT and 20 control clusters. The primary trial outcome was parasite prevalence in the final community survey. The primary entomological survey outcome was the annual entomological inoculation rate (aEIR) from July, 2014, to April, 2015. This trial is registered at ClinicalTrials.gov, number NCT02009215. Findings: Among 23 280 students registered in the 42 intervention schools, 10 079 (43%) aged 5–20 years were enrolled and received at least one dose of DP. 9286 (92%) of 10 079 received at least one full course of DP (three doses). Community-level parasite prevalence was lower in the intervention clusters than in the control clusters (19% vs 23%, adjusted risk ratio 0·85, 95% CI 0·73–1·00, p=0·05). The aEIR was lower in the intervention group than in the control group, but not significantly so (10·1 vs 15·2 infective bites per person, adjusted incidence rate ratio 0·80, 95% CI 0·36–1·80, p=0·59). Interpretation: IPT of schoolchildren with DP might have a positive effect on community-level malaria indicators and be operationally feasible. Studies with greater IPT coverage are needed. Funding: UK Medical Research Council, UK Department for International Development, and Wellcome Trust.

Published
2018

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