4 results on '"Sil, Sanchita"'
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2. List of Contributors
- Author
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Beć, Krzysztof B., primary, Bhatt, Chet R., additional, Chowdhury, Joydeep, additional, Coluccelli, Nicola, additional, Dasgupta, Jyotishman, additional, De Boni, Leonardo, additional, Delbeck, Sven, additional, Dubey, Pankaj, additional, Dwivedi, Yashashchandra, additional, Gautam, Rekha, additional, Ghany, Charles T., additional, Gupta, V.P., additional, Heise, H. Michael, additional, Huck, Christian W., additional, Jung, Young M., additional, Karir, Ginny, additional, Karmakar, Shreetama, additional, Kumar, Vikas, additional, Küpper, Lukas, additional, McIntyre, Dustin L., additional, Mendonça, Cleber R., additional, Mukhopadhyay, Anamika, additional, Noda, Isao, additional, Ozaki, Yukihiro, additional, Polli, Dario, additional, Prabhu, Shriganesh S., additional, Roy, Palas, additional, Saini, Jyoti, additional, Sil, Sanchita, additional, Singh, Jagdish P., additional, Thakur, Surya N., additional, Umapathy, Siva, additional, Verma, Kanupriya, additional, Viswanathan, K.S., additional, Vivas, Marcelo G., additional, Xu, Yizhuang, additional, and Yueh, Fang Y., additional
- Published
- 2018
- Full Text
- View/download PDF
3. Potential of Raman spectroscopic techniques to study proteins.
- Author
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Kuhar N, Sil S, and Umapathy S
- Subjects
- Amino Acids, Muramidase, Protein Structure, Secondary, Protein Folding, Spectrum Analysis, Raman
- Abstract
Proteins are large, complex molecules responsible for various biological processes. However, protein misfolding may lead to various life-threatening diseases. Therefore, it is vital to understand the shape and structure of proteins. Despite numerous techniques, a mechanistic understanding of the protein folding process is still unclear. Therefore, new techniques are continually being explored. In the present article, we have discussed the importance of Raman spectroscopy, Raman Optical Activity (ROA) and various other advancements in Raman spectroscopy to understand protein structure and conformational changes based on the review of our earlier work and recent literature. A Raman spectrum of a protein provides unique signatures for various secondary structures like helices, beta-sheets, turns, random structures, etc., and various amino acid residues such as tyrosine, tryptophan, and phenylalanine. We have shown how Raman spectra can differentiate between bovine serum albumin (BSA) and lysozyme protein based on their difference in sequence and structure (primary, secondary and tertiary). Although it is challenging to elucidate the structure of a protein using a Raman spectrum alone, Raman spectra can be used to differentiate small changes in conformations of proteins such as BSA during melting. Various new advancements in technique and data analyses in Raman spectroscopic studies of proteins have been discussed. The last part of the review focuses on the importance of the ROA spectrum to understand additional features about proteins. The ROA spectrum is rich in information about the protein backbone due to its rigidity compared to its side chains. Furthermore, the ROA spectra of lysozyme and BSA have been presented to show how ROA provides extra information about the solvent properties of proteins., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2021. Published by Elsevier B.V.)
- Published
- 2021
- Full Text
- View/download PDF
4. Understanding phase transition and vibrational mode coupling in ammonium nitrate using 2D correlation Raman spectroscopy.
- Author
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Sil S, Kuhar N, Roy K, Chaturvedi D, Morita S, Ozaki Y, and Umapathy S
- Abstract
Ammonium nitrate (AN) is an important component of the chemical industry such as an active ingredient in fertilizers, as an oxidizer in explosive compositions and propellants, and as a blasting agent in civil explosives. Numerous accidents have been reported in the past which concerns its thermal instability and poses a big threat to its processing, transportation, and storage. Despite much literature being reported to understand its thermal instability, a mechanistic view remains unclear. In the present work, we have studied the behavior of AN to temperature change using a mathematical approach called 2D correlation (2D Cos) Raman spectroscopy to provide complete insight into the detailed dynamical nature of the interactions between the species (ionic or molecular) occurring with an increase in temperature. We have analyzed various libration and translational modes of nitrate in the low-frequency region using this mathematical tool. It is observed from 2D maps that the phase transition of AN starts with changes in libration modes followed by various nitrate modes and ammonium modes which further precedes low-frequency translational modes. Further, the 2D correlation could differentiate between modes splitting and shifting based on specific 2D Cos pattern. The changes occurring in the N-O deformation modes, symmetric stretching modes as well as anti-symmetric stretching modes which have been attributed to the weakening of the hetero-ionic coupling between the NH
4 + and the NO3 - ions could be clearly distinguished in the 2D synchronous and asynchronous plots. Besides, moving window analysis was performed to visualize the transition temperature at which phase change of AN takes place., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2021. Published by Elsevier B.V.)- Published
- 2021
- Full Text
- View/download PDF
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