1. The role of α2,3-linked sialylation on clear cell type epithelial ovarian cancer.
- Author
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Sung PL, Wen KC, Horng HC, Chang CM, Chen YJ, Lee WL, and Wang PH
- Subjects
- Adenocarcinoma, Clear Cell genetics, Adenocarcinoma, Clear Cell pathology, Animals, Cadherins genetics, Carcinoma, Ovarian Epithelial, Cell Line, Tumor, Cystadenocarcinoma, Serous genetics, Cystadenocarcinoma, Serous pathology, Female, Gene Expression drug effects, Gene Expression Regulation, Neoplastic drug effects, Humans, Mice, Neoplasms, Glandular and Epithelial genetics, Neoplasms, Glandular and Epithelial pathology, Oleanolic Acid analogs & derivatives, Oleanolic Acid pharmacology, Ovarian Neoplasms genetics, Ovarian Neoplasms pathology, Saponins pharmacology, Sialyltransferases antagonists & inhibitors, Sialyltransferases genetics, beta-Galactoside alpha-2,3-Sialyltransferase, Adenocarcinoma, Clear Cell metabolism, Cystadenocarcinoma, Serous metabolism, Neoplasms, Glandular and Epithelial metabolism, Ovarian Neoplasms metabolism, Sialyltransferases metabolism
- Abstract
Objective: Our previous study has shown that high expression of α2,3-sialytransferase type I was associated with advanced stage serous type epithelial ovarian cancer (EOC). The aim of the current study further attempts to evaluate the altered α 2,3-sialylation on the behavior of clear cell type EOC (C-EOC)., Materials and Methods: Immunohistochemistry staining, bioinformatics analysis and tissue array were used to disclose the clinical significance of over α2,3-sialylation in C-EOC. An α2,3 sialylation inhibitor, soyasaponin I (SsaI) was used to investigate the behavior change of the C-EOC cell line., Results: We reconfirmed that α2,3-sialylation, instead of α2,6- sialylation, was associated with late-stage C-EOC. Soyasaponin I could inhibit α2,3-sialylation of C-EOC cell lines and increase E-cadherin expression with subsequently suppressing migration of C-EOC cells., Conclusions: The current study demonstrated the important role of α2,3-linked sialylation in C-EOC and targeting of α2,3-linked sialylation might offer as a potential therapeutic strategy in the future., (Copyright © 2018. Published by Elsevier B.V.)
- Published
- 2018
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