Search

Your search keyword '"Shuangjie Liu"' showing total 2 results
Start Over Author "Shuangjie Liu" Publisher elsevier
2 results on '"Shuangjie Liu"'

1. Cancer-keeper genes as therapeutic targets

Author

Xizhe Zhang, Chunyu Pan, Xinru Wei, Meng Yu, Shuangjie Liu, Jun An, Jieping Yang, Baojun Wei, Wenjun Hao, Yang Yao, Yuyan Zhu, and Weixiong Zhang

Subjects
Therapeutics, Drugs, Cancer, Science
Abstract

Summary: Finding cancer-driver genes has been a central theme of cancer research. We took a different perspective; instead of considering normal cells, we focused on cancerous cells and genes that maintained abnormal cell growth, which we named cancer-keeper genes (CKGs). Intervening CKGs may rectify aberrant cell growth, making them potential cancer therapeutic targets. We introduced control-hub genes and developed an efficient algorithm by extending network controllability theory. Control hub are essential for maintaining cancerous states and thus can be taken as CKGs. We applied our CKG-based approach to bladder cancer (BLCA). All genes on the cell-cycle and p53 pathways in BLCA were identified as CKGs, showing their importance in cancer. We discovered that sensitive CKGs — genes easily altered by structural perturbation — were particularly suitable therapeutic targets. Experiments on cell lines and a mouse model confirmed that six sensitive CKGs effectively suppressed cancer cell growth, demonstrating the immense therapeutic potential of CKGs.

Published
2023
Full Text
View/download PDF

2. A global integrated analysis of UNC5C down-regulation in cancers: insights from mechanism and combined treatment strategy

Author

Siyang Jing, Yuyan Zhu, Meng Yu, Jiaxing Lin, Pinying Wang, Jieping Yang, Shuangjie Liu, and Haotian Xing

Subjects
0301 basic medicine, Tumor suppressor gene, medicine.medical_treatment, Down-Regulation, RM1-950, Protein degradation, Biology, UNC5C, Targeted therapy, Epigenetic regulation, 03 medical and health sciences, 0302 clinical medicine, Cell Line, Tumor, Pan-cancer analysis, medicine, Humans, Gene Regulatory Networks, Epigenetics, Pharmacology, Regulation of gene expression, Multi-omics, Sequence Analysis, RNA, Computational Biology, General Medicine, TCGA, Chromatin, Gene Expression Regulation, Neoplastic, 030104 developmental biology, 030220 oncology & carcinogenesis, Cancer cell, Cancer research, Therapeutics. Pharmacology, Netrin Receptors
Abstract

As the transmembrane receptor of Netrin-1, the tumor suppressor gene Unc-5 Netrin Receptor C (UNC5C) can trigger apoptosis. Although its tumor suppressor effects have been demonstrated in solid tumors such as colon cancer, there is still a lack of systematic research on its expression regulation mechanism. To address this need, we analyzed datasets from The Cancer Genome Atlas (TCGA) database, including multi-omics data for 32 types of cancers and 10,967 cases. Analysis of these data revealed a trend of significantly decreased UNC5C expression in 16 types of solid tumors. Additionally, low UNC5C expression is related to poor prognosis of five types of tumors and restoring the expression of UNC5C can effectively inhibit the proliferation potential of renal cancer cells. Promoter DNA methylation, chromatin remodeling-mediated epigenetic regulation, transcriptional inhibition, RNA-binding protein and miRNA-mediated post-transcriptional inhibition, genetic changes caused by deep deletion and truncated mutations, and ubiquitinating enzyme-mediated protein degradation can synergistically cause the down-regulation of UNC5C expression in solid tumors. This study is the first to analyze the comprehensive molecular mechanism of down-regulation of the tumor suppressor gene UNC5C from multiple dimensions using pan-cancer data. Our results suggest that analyses of gene expression regulation relying on computational biological methods may help guide the targeted therapy of tumor suppressor gene reactivation.

Published
2021

Catalog

Books, media, physical & digital resources
See catalog results