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Your search keyword '"Sergio Claudio Saccà"' showing total 5 results
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5 results on '"Sergio Claudio Saccà"'

1. Contributors

Author

Winsome Abbott-Johnson, Niyazi Acar, Asaf Achiron, Vaishali Agte, R.A. Armstrong, Bahri Aydın, Fereshteh Bahmani, Lionel Bretillon, Alain M. Bron, Zvia Burgansky-Eliash, Pramila Chaubey, Emina Čolak, Damian Cole, Marc Comaratta, M. Cossenza, Catherine P. Creuzot-Garcher, R.C. Cubbidge, R.P. Cubbidge, Carlo Alberto Cutolo, Alexandra P M de Koning-Backus, Maria Cristina de Oliveira Izar, Patricia Coelho de Velasco, I. Domith, T.G. Encarnação, Mesut Erdurmuş, Hamed Esfandiari, Rocío Estévez-Santiago, Asghar Farajzadeh, Silvia C. Finnemann, Francisco Antonio Helfenstein Fonseca, Christopher Fortenbach, Peter L. Gehlbach, Snehal Gite, Elissa Goldman, Paweł Grieb, Julia A. Haller, Sang Beom Han, Rijo Hayashi, Idan Hecht, Tatiana Helfenstein, Ruth E Hogg, Joon Young Hyon, Yao Jin, Kim Jiramongkolchai, Rahul K. Reddy, Frances H. Kazal, Paul Kerlin, Jessica C Kiefte-de Jong, Amar U. Kishan, Caroline C W Klaver, Kimitoshi Kohno, Dingbo Lin, Nils A. Loewen, Idit Maharshak, Shilpa Mathew, Francesca Mazzoni, Naoya Miyamoto, Bobeck S. Modjtahedi, Lawrence S. Morse, Manikanta Murahari, Nara Naranjit, Robert Kelechi Obi, Begoña Olmedilla-Alonso, R. Paes-de-Carvalho, Adela Pintea, C.C. Portugal, Jiang Qin, Marina Roizenblatt, Tommaso Rossi, Dumitriţa Rugină, Sergio Claudio Saccà, Poliana Capucho Sandre, Preeti C. Sangave, Megha Sarkar, Claudio Alberto Serfaty, Horacio M. Serra, Juliet Adamma Shenge, Hüseyin Simavlı, R. Socodato, Marco Spinazzi, Krishnapura Srinivasan, Philip P. Storey, María Fernanda Suárez, Vasanti Suvarna, Mehmet Tosun, Jade Vargas, Jayne V Woodside, Lei Wu, Chen Xi, Ramazan Yağcı, Ji Yong, S. Zahra Bathaie, and Lepša Žorić

Published
2019

2. Glaucoma: An Overview

Author

Sergio Claudio Saccà, Carlo Alberto Cutolo, and Tommaso Rossi

Published
2019

3. Glaucoma

Author

Cristina Cartiglia, Sergio Claudio Saccà, and Alberto Izzotti

Subjects
medicine.medical_specialty, Intraocular pressure, genetic structures, business.industry, Glaucoma, medicine.disease, Retinal ganglion, eye diseases, Ganglion, medicine.anatomical_structure, Atrophy, Normal tension glaucoma, Ophthalmology, Genetic predisposition, medicine, sense organs, Trabecular meshwork, business
Abstract

Glaucoma is a disease known since the time of Hippocrates. Today, the term glaucoma refers to a spectrum of neurodegenerative diseases that have in common progressive optical atrophy resulting from the apoptosis of retinal ganglion cells, and axonal atrophy and degeneration extending to the visual areas of the brain cortex, finally leading to the characteristic optical-cup neuropathy and irreversible visual loss. The action of many factors, including aging, genetic predisposition, exogenous environmental and endogenous factors, is necessary for the development of glaucoma. In addition to ganglion cell loss, most glaucoma types are characterized by high intraocular pressure. This is due to the damage that occurs in the trabecular meshwork, a key region in the pathogenesis of high-pressure glaucoma. In normal-pressure glaucoma, the pathogenesis is different, with vascular factors playing a very important role.

Published
2014

4. Contributors

Author

Winsome Abbott-Johnson, Niyazi Acar, Vaishali Agte, Daniel Agudelo, Maria Antonietta Altea, R.A. Armstrong, Tin Aung, Bahri Aydın, Fereshteh Bahmani, D. Balmer, S. Zahra Bathaie, Lynne Bell, Tos T.J.M. Berendschot, Paul S. Bernstein, Brian M. Besch, Philippe Bourassa, R.B. Bozard, Lionel Bretillon, Alain M. Bron, Benjamin Buaud, Gabriëlle H.S. Buitendijk, Laurie T. Butler, Aldo Caporossi, Stefano Caragiuli, Chloé Cartier, Cristina Cartiglia, Chi-Ming Chan, Min-Lee Chang, Bashira A. Charles, Emily Y. Chew, Ching-Yu Cheng, Chung-Jung Chiu, Deepika Chopra, Patricia Coelho de Velasco, David Coman, Nicole Combe, Dolores Corella, M. Cossenza, Simonetta Costa, Catherine P. Creuzot-Garcher, Maria Cristina de Oliveira Izar, R.P. Cubbidge, Alyssa Cwanger, Cécile Delcourt, Marie-Noëlle Delyfer, I.C.L. Domith, David Dunaief, Joshua L. Dunaief, Rajan Elanchezhian, Andrew W. Eller, T.G. Encarnação, Mesut Erdurmuş, Evangelina Espósito, Asghar Farajzadeh, David T. Field, Silvia C. Finnemann, Steven J. Fliesler, Nicolas Froger, P.S. Ganapathy, V. Ganapathy, Jose J. Garcia-Medina, Pitchairaj Geraldine, Carmen Giannantonio, C.R. Gibson, Snehal Gite, N. Goldenberg-Cohen, Glen Gole, Ian R. Gorovoy, Julia A. Haller, Lisa Hark, Rijo Hayashi, Hui He, Tatiana Helfenstein, Francisco Antonio Helfenstein Fonseca, Ken-ichi Hosoya, Yi-Ling Huang, Chi-Feng Hung, M. Ibberson, Hiroto Izumi, Alberto Izzotti, Riikka L. Järvinen, Hua Ji, Yao Jin, Corinne Joffre, Choun-Ki Joo, Sang Hoon Jung, Heikki P. Kallio, Paul Kerlin, Eun Chul Kim, Jin Sook Kim, Amar U. Kishan, Caroline C.W. Klaver, Kimitoshi Kohno, Jean-François Korobelnik, Yoshiyuki Kubo, Petra S. Larmo, Ryszard Lauterbach, Ling-Jun Li, Dingbo Lin, M.I. Lopez-Galvez, Yi Lu, Zhi-Quan Lu, F. Manco Lavado, Claudio Marcocci, Shilpa Mathew, Cosimo Mazzotta, Francesca Menconi, Naoya Miyamoto, Bobeck S. Modjtahedi, Lawrence S. Morse, Sarah W. Mount, Arumugam R. Muralidharan, Benjamin P. Nicholson, R. Paes-de-Carvalho, J.C. Pastor, Dorota Pawlik, John F. Payne, Daniel Petrovič, Serge Picaud, Maria D. Pinazo-Duran, Adela Mariana Pintea, Jogchum Plat, C.C. Portugal, Ananda S. Prasad, Victor R. Preedy, Jiang Qin, R. Roduit, Costantino Romagnoli, Marie-Bénédicte Rougier, Dumitriţa Olivia Rugină, Charumathi Sabanayagam, Sergio Claudio Saccà, José-Alain Sahel, Dave Saint-Amour, Pedro Sanz-Solana, Seang Mei Saw, D.F. Schorderet, Claudio Alberto Serfaty, Horacio M. Serra, Saumil Sethna, Jay Siak, Hüseyin Simavlı, S.B. Smith, S.M. Smith, R. Socodato, Marco Spinazzi, K. Srinivasan, Philip Storey, María Fernanda Suárez, H.A. Tajmir-Riahi, Gavin S. Tan, Vin Tangpricha, Akihiko Tawara, P. Archana Teresa, Philip A. Thomas, Mehmet Tosun, Julio A. Urrets-Zavalía, Preejith P. Vachali, Carole Vaysse, Sabrina Viau, Claire M. Williams, Tien Y. Wong, Chen Xi, Ramazan Yağcı, Jia Yan, Baoru Yang, Ji Yong, Vicente Zanon-Moreno, Xiangjia Zhu, and S.R. Zwart

Published
2014

5. Oxidative stress and glaucoma: injury in the anterior segment of the eye

Author

Alberto Izzotti and Sergio Claudio Saccà

Subjects
medicine.hormone, Intraocular pressure, medicine.medical_specialty, genetic structures, DNA damage, Glaucoma, Anatomy, Biology, medicine.disease, medicine.disease_cause, Retinal ganglion, eye diseases, Endothelins, medicine.anatomical_structure, Endocrinology, Internal medicine, Optic nerve, medicine, sense organs, Trabecular meshwork, Oxidative stress
Abstract

The perturbation of the pro-oxidant/antioxidant balance can lead to increased oxidative damage, especially when the first line of antioxidant defense weakens with age. Chronic changes in the composition of factors present in aqueous or vitreous humor may induce alterations both in trabecular cells and in cells of the optic nerve head. Free radicals and reactive oxygen species are able to affect the cellularity of the human trabecular meshwork (HTM). These findings suggest that intraocular pressure increase, which characterizes most glaucomas, is related to oxidative and degenerative processes affecting the HTM and, more specifically, its endothelial cells. This supports the theory that glaucomatous damage is the pathophysiological consequence of oxidative stress. Glaucomatous subjects might have a genetic predisposition, rendering them more susceptible to reactive oxygen species-induced damage. It is likely that specific genetic factors contribute to both the elevation of IOP and susceptibility of the optic nerve/retinal ganglion cells (RGCs) to degeneration. Thus, oxidative stress plays a fundamental role during the arising of glaucoma-associated lesions, first in the HTM and then, when the balance between nitric oxide and endothelins is broken, in neuronal cell. Vascular damage and hypoxia, often associated with glaucoma, lead to apoptosis of RGCs and may also contribute to the induction of oxidative damage to the HTM. On the whole, these findings support the hypothesis that oxidative damage is an important step in the pathogenesis of primary open-angle glaucoma and might be a relevant target for both prevention and therapy.

Published
2008

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