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3 results on '"Serana F"'

1. Imaging increased metabolism in the spinal cord in mice after middle cerebral artery occlusion

Author

Ruiqing Ni, Nadja Straumann, Serana Fazio, Xose Luis Dean-Ben, Georgios Louloudis, Claudia Keller, Daniel Razansky, Simon Ametamey, Linjing Mu, César Nombela-Arrieta, and Jan Klohs

Subjects
fluorodeoxyglucose (FDG), Ischemic stroke, Metabolism, MSOT, Optoacoustic tomography, Oxygenation, Physics, QC1-999, Acoustics. Sound, QC221-246, Optics. Light, QC350-467
Abstract

Emerging evidence indicates crosstalk between the brain and hematopoietic system following cerebral ischemia. Here, we investigated metabolism and oxygenation in the spleen and spinal cord in a transient middle cerebral artery occlusion (tMCAO) model. Sham-operated and tMCAO mice underwent [18F]fluorodeoxyglucose (FDG)-positron emission tomography (PET) to assess glucose metabolism. Naïve, sham-operated and tMCAO mice underwent multispectral optoacoustic tomography (MSOT) assisted by quantitative model-based reconstruction and unmixing algorithms for accurate mapping of oxygenation patterns in peripheral tissues at 24 h after reperfusion. We found increased [18F]FDG uptake and reduced MSOT oxygen saturation, indicating hypoxia in the thoracic spinal cord of tMCAO mice compared with sham-operated mice but not in the spleen. Reduced spleen size was observed in tMCAO mice compared with sham-operated mice ex vivo. tMCAO led to an increase in the numbers of mature T cells in femoral bone marrow tissues, concomitant with a stark reduction in these cell subsets in the spleen and peripheral blood. The combination of quantitative PET and MSOT thus enabled observation of hypoxia and increased metabolic activity in the spinal cord of tMCAO mice at 24 h after occlusion compared to sham-operated mice.

Published
2023
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2. Opposite effects of interferon-beta on new B and T cell release from production sites in multiple sclerosis patients

Author

Zanotti, C, Chiarini, M, Serana, F, Capra, R, Rottoli, M, Rovaris, M, Cavaletti, G, Clerici, R, Rezzonico, M, Caimi, L, Imberti, L, Imberti, L., CAVALETTI, GUIDO ANGELO, Zanotti, C, Chiarini, M, Serana, F, Capra, R, Rottoli, M, Rovaris, M, Cavaletti, G, Clerici, R, Rezzonico, M, Caimi, L, Imberti, L, Imberti, L., and CAVALETTI, GUIDO ANGELO

Abstract

The release of newly produced B and T lymphocytes from the production sites was analyzed in 30 multiple sclerosis patients treated with interferon-beta by measuring T-cell receptor excision circles and k-deleting recombination excision circles. We found that the therapy induces opposite effects on B- and T-cell mobilization in 33% of patients. New B-cell production, which peaks after 6months of therapy and then decreases to levels that, however, are still higher than in controls, may cause a renewal of the B-cell compartment. On the contrary, the decreased number of newly produced T lymphocytes observed at 12months of treatment and the association between reduced thymic output and low peripheral T lymphocytes can be a cause of leukopenia, a frequent side effect of the therapy.

Published
2012

3. Opposite effects of interferon-beta on new B and T cell release from production sites in multiple sclerosis patients

Author

Raffaella Clerici, Cinzia Zanotti, Monica Rezzonico, Marco Chiarini, Federico Serana, Marco Rovaris, M Rottoli, Luigi Caimi, Ruggero Capra, Guido Cavaletti, Luisa Imberti, Zanotti, C, Chiarini, M, Serana, F, Capra, R, Rottoli, M, Rovaris, M, Cavaletti, G, Clerici, R, Rezzonico, M, Caimi, L, and Imberti, L

Subjects
Adult, Male, Side effect, multiple sclerosis, lymphocytes, interferon-beta, T cell, Immunology, B-Lymphocyte Subsets, Biology, Young Adult, Multiple Sclerosis, Relapsing-Remitting, T-Lymphocyte Subsets, medicine, Humans, Immunology and Allergy, Receptor, Cell Proliferation, Leukopenia, T-cell receptor excision circles, Multiple sclerosis, Compartment (ship), Cell Differentiation, Interferon-beta, Middle Aged, medicine.disease, Peripheral, medicine.anatomical_structure, Neurology, Female, Neurology (clinical), medicine.symptom, Follow-Up Studies
Abstract

The release of newly produced B and T lymphocytes from the production sites was analyzed in 30 multiple sclerosis patients treated with interferon-beta by measuring T-cell receptor excision circles and k-deleting recombination excision circles. We found that the therapy induces opposite effects on B- and T-cell mobilization in 33% of patients. New B-cell production, which peaks after 6 months of therapy and then decreases to levels that, however, are still higher than in controls, may cause a renewal of the B-cell compartment. On the contrary, the decreased number of newly produced T lymphocytes observed at 12 months of treatment and the association between reduced thymic output and low peripheral T lymphocytes can be a cause of leukopenia, a frequent side effect of the therapy.

Published
2012

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