45 results on '"Satija, S."'
Search Results
2. Targeting eosinophils in chronic respiratory diseases using nanotechnology-based drug delivery.
- Author
-
Sharma, P, Dhanjal, DS, Chopra, C, Tambuwala, MM, Sohal, SS, van der Spek, PJ, Sharma, HS, Satija, S, Sharma, P, Dhanjal, DS, Chopra, C, Tambuwala, MM, Sohal, SS, van der Spek, PJ, Sharma, HS, and Satija, S
- Abstract
Asthma, COPD, COVID-19, EGPA, Lung cancer, and Pneumonia are major chronic respiratory diseases (or CRDs) affecting millions worldwide and account for substantial morbidity and mortality. These CRDs are irreversible diseases that affect different parts of the respiratory system, imposing a considerable burden on different socio-economic classes. All these CRDs have been linked to increased eosinophils in the lungs. Eosinophils are essential immune mediators that contribute to tissue homeostasis and the pathophysiology of various diseases. Interestingly, elevated eosinophil level is associated with cellular processes that regulate airway hyperresponsiveness, airway remodeling, mucus hypersecretion, and inflammation in the lung. Therefore, eosinophil is considered the therapeutic target in eosinophil-mediated lung diseases. Although, conventional medicines like antibiotics, anti-inflammatory drugs, and bronchodilators are available to prevent CRDs. But the development of resistance to these therapeutic agents after long-term usage remains a challenge. However, progressive development in nanotechnology has unveiled the targeted nanocarrier approach that can significantly improve the pharmacokinetics of a therapeutic drug. The potential of the nanocarrier system can be specifically targeted on eosinophils and their associated components to obtain promising results in the pharmacotherapy of CRDs. This review intends to provide knowledge about eosinophils and their role in CRDs. Moreover, it also discusses nanocarrier drug delivery systems for the targeted treatment of CRDs.
- Published
- 2022
3. Pharmacological evaluation of bromelain in mouse model of Alzheimer's disease
- Author
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Kumar, R, Sharma, N, Khurana, N, Singh, SK, Satija, S, Mehta, M, and Vyas, M
- Subjects
Memory Disorders ,Galactose ,1109 Neurosciences, 1115 Pharmacology and Pharmaceutical Sciences ,Toxicology ,Bromelains ,Hippocampus ,Disease Models, Animal ,Mice ,Oxidative Stress ,Neuroprotective Agents ,Alzheimer Disease ,Aluminum Chloride ,Animals ,Donepezil ,Maze Learning - Abstract
The current study elucidates pharmacological evaluation of bromelain as a bioactive compound obtain from pineapple stem belongs to family Bromeliaceae in AlCl3 and D - galactose induced mice. In mice, co-administration of AlCl3 at dose 5 mg/kg b.w., via the oral route, and D - galactose at dose 60 mg/kg b.w., via intraperitoneal route for 90 days resulted in cognitive impairment, spatial learning, and memory deficits, as well as neurotoxicity. However, 30 consecutive days, treatments via an intraperitoneal route with bromelain low dose (Brm L) at dose 10 mg/kg b.w., bromelain high dose (Brm H) at dose 20 mg/kg b.w., donepezil (Dnpz) at dose 2 mg/kg b.w., and Brm L + Dnpz at doses 10, 2 mg/kg b.w. were considerably reversed the effect of AlCl3 and D - galactose induced AD mice. Consequences of behavioral parameters (Morris water maze, elevated plus maze and locomotor), biochemical estimation (MDA, GSH, SOD, CAT, Nitrite and AChE), and ELISA tests (mouse BACE, Aβ1 - 42, TNF-α, IL-6, and BDNF) confirmed significant (p
- Published
- 2022
4. Introduction to cancer cell biology
- Author
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Shaikh, MA, Gilhotra, R, Singh, SK, Rawat, S, Gupta, G, Hussain, S, Singh, Y, Satija, S, Mehta, M, and Dua, K
- Abstract
Cancer comprises more than 200 genetically related diseases in which information about cells stored in DNA is altered, resulting in changes in gene expression and abnormal cell development, proliferation, and metastasis. Genetic factors, environmental factors, lifestyle factors, occupations, and certain biological factors play a crucial role in the development of various types of cancer. There are eight distinguishing and harmonizing features or hallmarks of cancer cells. These include sustained multiplication (proliferative) signaling, avoidance of immune annihilation (destruction), deregulation of cell energetics, avoidance of apoptosis, shunning of anti-growth signals, metastasis and tissue invasion, endless multiplication (replication) potential, and extended (sustained) tumor angiogenesis. There are two characteristics that enable tumor growth and metastasis: genetic instability and mutability, and inflammation.
- Published
- 2021
5. Chapter 15 Novel Controlled Release Pulmonary Drug Delivery Systems: Current updates and Challenges
- Author
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Dhanjal, DS, Mehta, M, Chopra, C, Singh, R, Sharma, P, Chellappan, DK, Tambuwala, MM, Bakshi, HA, Aljabali, AAA, Gupta, G, Nammi, S, Prasher, P, Dua, K, and Satija, S
- Published
- 2021
6. Chapter 35 Targeting siRNAs in cancer drug delivery
- Author
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Obeid, MA, Aljabali, AAA, Alshaer, W, Charbe, NB, Chellappan, DK, Dua, K, Satija, S, and Tambuwala, MM
- Published
- 2021
7. Nanotechnology based advanced therapeutic strategies for targeting interleukins in chronic respiratory diseases.
- Author
-
Hussain, MS, Sharma, P, Dhanjal, DS, Khurana, N, Vyas, M, Sharma, N, Mehta, M, Tambuwala, MM, Satija, S, Sohal, SS, Oliver, BGG, Sharma, HS, Hussain, MS, Sharma, P, Dhanjal, DS, Khurana, N, Vyas, M, Sharma, N, Mehta, M, Tambuwala, MM, Satija, S, Sohal, SS, Oliver, BGG, and Sharma, HS
- Abstract
Both communicable and non-communicable chronic respiratory conditions have accorded for suffering of millions of people of all ages and stated to be leading cause of death, morbidity, economic and social pressures, and disability-adjusted life-years (DALYs) worldwide. These illnesses impair patient's health and negatively impacts families and society, particularly in low and middle-income countries. Chronic respiratory diseases (CRDs) affect different organs of respiratory system, involving airways, parenchyma, and pulmonary vasculature. As the number of respiratory diseases are exponentially escalating but still the stakeholders are not paying attention towards its serious complications. Currently, the treatment being used primarily focusses only on alleviating symptoms of these illness rather delivering the therapeutic agent at target site for optimal care and/or prevention. Lately, extensive research is being conducted on airways and systemic inflammation, oxidative stress, airway, or parenchymal rehabilitation. From which macrophages, neutrophils, and T cells, as well as structural cells as fibroblasts, epithelial, endothelial, and smooth muscle cells have been found to be active participants that are involved in these chronic respiratory diseases. The pathogenesis of all these chronic respiratory diseases gets caused differently via mediators and proteins, including cytokines, chemokines, growth factors and oxidants. Presently, the target of prescription therapies is to reduce the inflammation of airways and relieve the airway contraction. In all studies, cytokines have been found to play an imperative role in fostering chronic airway inflammation and remodelling. Owing to the limitations of conventional treatments, the current review aims to summarize the current knowledge about the chronic respiratory disease and discuss further about the various conventional methods that can be used for treating this ailment. Additionally, it also highlights and discusses ab
- Published
- 2021
8. Targeting eosinophils in respiratory diseases: Biological axis, emerging therapeutics and treatment modalities.
- Author
-
Lee, L-Y, Hew, GSY, Meenu, Shukla, SD, Satija, S, Khurana, N, Anand, K, Dureja, H, Singh, SK, Mishra, V, Singh, PK, Gulati, M, Prasher, P, Aljabali, AAA, Tambuwala, MM, Thangavelu, L, Panneerselvam, J, Gupta, G, Zacconi, FC, Shastri, M, Jha, NK, Xenaki, D, MacLoughlin, R, Oliver, BG, Chellappan, DK, Dua, K, Lee, L-Y, Hew, GSY, Meenu, Shukla, SD, Satija, S, Khurana, N, Anand, K, Dureja, H, Singh, SK, Mishra, V, Singh, PK, Gulati, M, Prasher, P, Aljabali, AAA, Tambuwala, MM, Thangavelu, L, Panneerselvam, J, Gupta, G, Zacconi, FC, Shastri, M, Jha, NK, Xenaki, D, MacLoughlin, R, Oliver, BG, Chellappan, DK, and Dua, K
- Abstract
Eosinophils are bi-lobed, multi-functional innate immune cells with diverse cell surface receptors that regulate local immune and inflammatory responses. Several inflammatory and infectious diseases are triggered with their build up in the blood and tissues. The mobilization of eosinophils into the lungs is regulated by a cascade of processes guided by Th2 cytokine generating T-cells. Recruitment of eosinophils essentially leads to a characteristic immune response followed by airway hyperresponsiveness and remodeling, which are hallmarks of chronic respiratory diseases. By analysing the dynamic interactions of eosinophils with their extracellular environment, which also involve signaling molecules and tissues, various therapies have been invented and developed to target respiratory diseases. Having entered clinical testing, several eosinophil targeting therapeutic agents have shown much promise and have further bridged the gap between theory and practice. Moreover, researchers now have a clearer understanding of the roles and mechanisms of eosinophils. These factors have successfully assisted molecular biologists to block specific pathways in the growth, migration and activation of eosinophils. The primary purpose of this review is to provide an overview of the eosinophil biology with a special emphasis on potential pharmacotherapeutic targets. The review also summarizes promising eosinophil-targeting agents, along with their mechanisms and rationale for use, including those in developmental pipeline, in clinical trials, or approved for other respiratory disorders.
- Published
- 2021
9. Nanomedicine advances in cancer therapy
- Author
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Hinge, N, Pandey, MM, Singhvi, G, Gupta, G, Mehta, M, Satija, S, Gulati, M, Dureja, H, and Dua, K
- Abstract
The book highlights the most recent advances in both nanosystems and 3D-printed systems for both drug delivery and tissue engineering applications.
- Published
- 2020
10. Targeting eosinophils in chronic respiratory diseases using nanotechnology-based drug delivery.
- Author
-
Sharma P, Dhanjal DS, Chopra C, Tambuwala MM, Sohal SS, van der Spek PJ, Sharma HS, and Satija S
- Subjects
- Eosinophils, Humans, Lung, Nanotechnology, Asthma drug therapy, COVID-19 Drug Treatment
- Abstract
Asthma, COPD, COVID-19, EGPA, Lung cancer, and Pneumonia are major chronic respiratory diseases (or CRDs) affecting millions worldwide and account for substantial morbidity and mortality. These CRDs are irreversible diseases that affect different parts of the respiratory system, imposing a considerable burden on different socio-economic classes. All these CRDs have been linked to increased eosinophils in the lungs. Eosinophils are essential immune mediators that contribute to tissue homeostasis and the pathophysiology of various diseases. Interestingly, elevated eosinophil level is associated with cellular processes that regulate airway hyperresponsiveness, airway remodeling, mucus hypersecretion, and inflammation in the lung. Therefore, eosinophil is considered the therapeutic target in eosinophil-mediated lung diseases. Although, conventional medicines like antibiotics, anti-inflammatory drugs, and bronchodilators are available to prevent CRDs. But the development of resistance to these therapeutic agents after long-term usage remains a challenge. However, progressive development in nanotechnology has unveiled the targeted nanocarrier approach that can significantly improve the pharmacokinetics of a therapeutic drug. The potential of the nanocarrier system can be specifically targeted on eosinophils and their associated components to obtain promising results in the pharmacotherapy of CRDs. This review intends to provide knowledge about eosinophils and their role in CRDs. Moreover, it also discusses nanocarrier drug delivery systems for the targeted treatment of CRDs., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2022. Published by Elsevier B.V.)
- Published
- 2022
- Full Text
- View/download PDF
11. Intra-genomic heterogeneity in CpG dinucleotide composition in dengue virus.
- Author
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Jaglan A, Satija S, Singh D, Phartyal R, and Verma M
- Subjects
- Dinucleoside Phosphates, Genomics, Humans, RNA, Messenger, Dengue prevention & control, Dengue Virus genetics
- Abstract
Purpose: Dengue virus is a life-threatening virus and cases of dengue infection have been increasing steadily in the past decades causing millions of deaths every year. So far, there is no vaccine that works effectively on all serotypes. Recently, CpG-recoded vaccines have proved to be effective against few viruses., Methods: In this study, evaluation and interpretation of more than 4547 Dengue virus genome sequences were included for analyzing novel CpG dinucleotides rich regions which are shared amid all serotypes. Genomic regions of DENV were synonymously CpG recoded using in silico methods and analyzed for adaptation in both human and Aedes spp. hosts based on CAI scores., Results: The analysis mirrored that serotypes 1, 3, and 4 shared CpG islands present in common regions. DENV-2 CpG islands showed no similarity with any of the CpG islands present in other serotypes. While DENV-3 sequences were found to possess the maximum number of conserved CpG islands stretches; DENV-2 was found to possess the lowest number. We found that all serotypes (with an exception of serotype 2) have CpG island in their 3' UTR. In silico CpG recoding of DENV genomic regions resulted in ∼ 3 fold increase of CpG dinucleotide frequency and comparative analysis based on CAI scores showed decreased adaptive fitness of CpG recoded DENV inside human host., Conclusion: These CG-dinucleotide-enriched RNA sequences can be targeted by ZAP (zinc-finger antiviral protein) which can differentiate between host mRNA and viral mRNA. Our in silico findings can further be exploited for CpG-recoding of DENV genomes which can evoke cellular and humoral immune responses by recruiting ZAP-induced RNA degradation machinery and hence providing a promising approach for vaccine development., (Copyright © 2022 Elsevier B.V. All rights reserved.)
- Published
- 2022
- Full Text
- View/download PDF
12. A new era in oxygen therapeutics? From perfluorocarbon systems to haemoglobin-based oxygen carriers.
- Author
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Charbe NB, Castillo F, Tambuwala MM, Prasher P, Chellappan DK, Carreño A, Satija S, Singh SK, Gulati M, Dua K, González-Aramundiz JV, and Zacconi FC
- Subjects
- Hemoglobins therapeutic use, Humans, Nitric Oxide therapeutic use, Oxygen therapeutic use, Blood Substitutes therapeutic use, Fluorocarbons
- Abstract
Blood transfusion is the key to life in case of traumatic emergencies, surgeries and in several pathological conditions. An important goal of whole blood or red blood cell transfusion is the fast delivery of oxygen to vital organs and restoration of circulation volume. Whole blood or red blood cell transfusion has several limitations. Free haemoglobin not only loses its tetrameric configuration and extracts via the kidney leading to nephrotoxicity but also scavenges nitric oxide (NO), leading to vasoconstriction and hypertension. PFC based formulations transport oxygen in vivo, the contribution in terms of clinical outcome is challenging. The oxygen-carrying capacity is not the only criterion for the successful development of haemoglobin-based oxygen carriers (HBOCs). This review is a bird's eye view on the present state of the PFCs and HBOCs in which we analyzed the current modifications made or which are underway in development, their promises, and hurdles in clinical implementation., (Copyright © 2022. Published by Elsevier Ltd.)
- Published
- 2022
- Full Text
- View/download PDF
13. Nanotechnology based advanced therapeutic strategies for targeting interleukins in chronic respiratory diseases.
- Author
-
Hussain MS, Sharma P, Dhanjal DS, Khurana N, Vyas M, Sharma N, Mehta M, Tambuwala MM, Satija S, Sohal SS, Oliver BGG, and Sharma HS
- Abstract
Both communicable and non-communicable chronic respiratory conditions have accorded for suffering of millions of people of all ages and stated to be leading cause of death, morbidity, economic and social pressures, and disability-adjusted life-years (DALYs) worldwide. These illnesses impair patient's health and negatively impacts families and society, particularly in low and middle-income countries. Chronic respiratory diseases (CRDs) affect different organs of respiratory system, involving airways, parenchyma, and pulmonary vasculature. As the number of respiratory diseases are exponentially escalating but still the stakeholders are not paying attention towards its serious complications. Currently, the treatment being used primarily focusses only on alleviating symptoms of these illness rather delivering the therapeutic agent at target site for optimal care and/or prevention. Lately, extensive research is being conducted on airways and systemic inflammation, oxidative stress, airway, or parenchymal rehabilitation. From which macrophages, neutrophils, and T cells, as well as structural cells as fibroblasts, epithelial, endothelial, and smooth muscle cells have been found to be active participants that are involved in these chronic respiratory diseases. The pathogenesis of all these chronic respiratory diseases gets caused differently via mediators and proteins, including cytokines, chemokines, growth factors and oxidants. Presently, the target of prescription therapies is to reduce the inflammation of airways and relieve the airway contraction. In all studies, cytokines have been found to play an imperative role in fostering chronic airway inflammation and remodelling. Owing to the limitations of conventional treatments, the current review aims to summarize the current knowledge about the chronic respiratory disease and discuss further about the various conventional methods that can be used for treating this ailment. Additionally, it also highlights and discusses about the advanced drug delivery system that are being used for targeting the interleukins for the treatment of CRDs., (Copyright © 2021 Elsevier B.V. All rights reserved.)
- Published
- 2021
- Full Text
- View/download PDF
14. Targeting eosinophils in respiratory diseases: Biological axis, emerging therapeutics and treatment modalities.
- Author
-
Lee LY, Hew GSY, Mehta M, Shukla SD, Satija S, Khurana N, Anand K, Dureja H, Singh SK, Mishra V, Singh PK, Gulati M, Prasher P, Aljabali AAA, Tambuwala MM, Thangavelu L, Panneerselvam J, Gupta G, Zacconi FC, Shastri M, Jha NK, Xenaki D, MacLoughlin R, Oliver BG, Chellappan DK, and Dua K
- Subjects
- Animals, Cytokines immunology, Cytokines metabolism, Eosinophils drug effects, Eosinophils metabolism, Humans, Lung metabolism, Lung pathology, Respiration Disorders metabolism, Respiration Disorders physiopathology, Respiratory Tract Diseases metabolism, Respiratory Tract Diseases physiopathology, Th2 Cells immunology, Th2 Cells metabolism, Eosinophils immunology, Respiration Disorders immunology, Respiratory Tract Diseases immunology
- Abstract
Eosinophils are bi-lobed, multi-functional innate immune cells with diverse cell surface receptors that regulate local immune and inflammatory responses. Several inflammatory and infectious diseases are triggered with their build up in the blood and tissues. The mobilization of eosinophils into the lungs is regulated by a cascade of processes guided by Th2 cytokine generating T-cells. Recruitment of eosinophils essentially leads to a characteristic immune response followed by airway hyperresponsiveness and remodeling, which are hallmarks of chronic respiratory diseases. By analysing the dynamic interactions of eosinophils with their extracellular environment, which also involve signaling molecules and tissues, various therapies have been invented and developed to target respiratory diseases. Having entered clinical testing, several eosinophil targeting therapeutic agents have shown much promise and have further bridged the gap between theory and practice. Moreover, researchers now have a clearer understanding of the roles and mechanisms of eosinophils. These factors have successfully assisted molecular biologists to block specific pathways in the growth, migration and activation of eosinophils. The primary purpose of this review is to provide an overview of the eosinophil biology with a special emphasis on potential pharmacotherapeutic targets. The review also summarizes promising eosinophil-targeting agents, along with their mechanisms and rationale for use, including those in developmental pipeline, in clinical trials, or approved for other respiratory disorders., (Copyright © 2021 Elsevier Inc. All rights reserved.)
- Published
- 2021
- Full Text
- View/download PDF
15. Targeting respiratory diseases using miRNA inhibitor based nanotherapeutics: Current status and future perspectives.
- Author
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Mehta M, Satija S, Paudel KR, Malyla V, Kannaujiya VK, Chellappan DK, Bebawy M, Hansbro PM, Wich PR, and Dua K
- Subjects
- Animals, Humans, Lung Neoplasms drug therapy, Lung Neoplasms metabolism, Nanocapsules chemistry, Nanotechnology methods, Polymers chemistry, Antagomirs chemistry, Antagomirs therapeutic use, MicroRNAs antagonists & inhibitors, MicroRNAs metabolism, Nanoparticles chemistry
- Abstract
MicroRNAs (miRNAs) play a fundamental role in the developmental and physiological processes that occur in both animals and plants. AntagomiRs are synthetic antagonists of miRNA, which prevent the target mRNA from suppression. Therapeutic approaches that modulate miRNAs have immense potential in the treatment of chronic respiratory disorders. However, the successful delivery of miRNAs/antagomiRs to the lungs remains a major challenge in clinical applications. A range of materials, namely, polymer nanoparticles, lipid nanocapsules and inorganic nanoparticles, has shown promising results for intracellular delivery of miRNA in chronic respiratory disorders. This review discusses the current understanding of miRNA biology, the biological roles of antagomiRs in chronic respiratory disease and the recent advances in the therapeutic utilization of antagomiRs as disease biomarkers. Furthermore our review provides a common platform to debate on the nature of antagomiRs and also addresses the viewpoint on the new generation of delivery systems that target antagomiRs in respiratory diseases., (Copyright © 2020 Elsevier Inc. All rights reserved.)
- Published
- 2021
- Full Text
- View/download PDF
16. Small interfering RNA for cancer treatment: overcoming hurdles in delivery.
- Author
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Charbe NB, Amnerkar ND, Ramesh B, Tambuwala MM, Bakshi HA, Aljabali AAA, Khadse SC, Satheeshkumar R, Satija S, Metha M, Chellappan DK, Shrivastava G, Gupta G, Negi P, Dua K, and Zacconi FC
- Abstract
In many ways, cancer cells are different from healthy cells. A lot of tactical nano-based drug delivery systems are based on the difference between cancer and healthy cells. Currently, nanotechnology-based delivery systems are the most promising tool to deliver DNA-based products to cancer cells. This review aims to highlight the latest development in the lipids and polymeric nanocarrier for siRNA delivery to the cancer cells. It also provides the necessary information about siRNA development and its mechanism of action. Overall, this review gives us a clear picture of lipid and polymer-based drug delivery systems, which in the future could form the base to translate the basic siRNA biology into siRNA-based cancer therapies., Competing Interests: The authors have no conflicts of interest to declare., (© 2020 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.)
- Published
- 2020
- Full Text
- View/download PDF
17. Perspectives and advancements in the design of nanomaterials for targeted cancer theranostics.
- Author
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Tan YY, Yap PK, Xin Lim GL, Mehta M, Chan Y, Ng SW, Kapoor DN, Negi P, Anand K, Singh SK, Jha NK, Lim LC, Madheswaran T, Satija S, Gupta G, Dua K, and Chellappan DK
- Subjects
- Antineoplastic Agents chemistry, Drug Carriers chemistry, Drug Design, Humans, Neoplasms pathology, Tumor Microenvironment, Antineoplastic Agents therapeutic use, Nanostructures chemistry, Neoplasms drug therapy, Theranostic Nanomedicine
- Abstract
Cancer continues to be one of the most challenging diseases to be treated and is one of the leading causes of deaths around the globe. Cancers account for 13% of all deaths each year, with cancer-related mortality expected to rise to 13.1 million by the year 2030. Although, we now have a large library of chemotherapeutic agents, the problem of non-selectivity remains the biggest drawback, as these substances are toxic not only to cancerous cells, but also to other healthy cells in the body. The limitations with chemotherapy and radiation have led to the discovery and development of novel strategies for safe and effective treatment strategies to manage the menace of cancer. Researchers have long justified and have shed light on the emergence of nanotechnology as a potential area for cancer therapy and diagnostics, whereby, nanomaterials are used primarily as nanocarriers or as delivery agents for anticancer drugs due to their tumor targeting properties. Furthermore, nanocarriers loaded with chemotherapeutic agents also overcome biological barriers such as renal and hepatic clearances, thus improving therapeutic efficacy with lowered morbidity. Theranostics, which is the combination of rationally designed nanomaterials with cancer-targeting moieties, along with protective polymers and imaging agents has become one of the core keywords in cancer research. In this review, we have highlighted the potential of various nanomaterials for their application in cancer therapy and imaging, including their current state and clinical prospects. Theranostics has successfully paved a path to a new era of drug design and development, in which nanomaterials and imaging contribute to a large variety of cancer therapies and provide a promising future in the effective management of various cancers. However, in order to meet the therapeutic needs, theranostic nanomaterials must be designed in such a way, that take into account the pharmacokinetic and pharmacodynamics properties of the drug for the development of effective carcinogenic therapy., (Copyright © 2020 Elsevier B.V. All rights reserved.)
- Published
- 2020
- Full Text
- View/download PDF
18. Plants derived therapeutic strategies targeting chronic respiratory diseases: Chemical and immunological perspective.
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Prasher P, Sharma M, Mehta M, Paudel KR, Satija S, Chellappan DK, Dureja H, Gupta G, Tambuwala MM, Negi P, Wich PR, Hansbro NG, Hansbro PM, and Dua K
- Subjects
- Animals, Chronic Disease, Humans, Plant Extracts chemistry, Plant Extracts therapeutic use, Respiratory Tract Diseases immunology, Molecular Targeted Therapy methods, Plant Extracts pharmacology, Respiratory Tract Diseases drug therapy
- Abstract
The apparent predicament of the representative chemotherapy for managing respiratory distress calls for an obligatory deliberation for identifying the pharmaceuticals that effectively counter the contemporary intricacies associated with target disease. Multiple, complex regulatory pathways manifest chronic pulmonary disorders, which require chemotherapeutics that produce composite inhibitory effect. The cost effective natural product based molecules hold a high fervor to meet the prospects posed by current respiratory-distress therapy by sparing the tedious drug design and development archetypes, present a robust standing for the possible replacement of the fading practice of poly-pharmacology, and ensure the subversion of a potential disease relapse. This study summarizes the experimental evidences on natural products moieties and their components that illustrates therapeutic efficacy on respiratory disorders., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2020 Elsevier B.V. All rights reserved.)
- Published
- 2020
- Full Text
- View/download PDF
19. Emerging trends in the novel drug delivery approaches for the treatment of lung cancer.
- Author
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Sharma P, Mehta M, Dhanjal DS, Kaur S, Gupta G, Singh H, Thangavelu L, Rajeshkumar S, Tambuwala M, Bakshi HA, Chellappan DK, Dua K, and Satija S
- Subjects
- Antineoplastic Agents chemistry, Antineoplastic Agents therapeutic use, Dendrimers chemistry, Humans, Liposomes chemistry, Lung Neoplasms pathology, Nanoparticles chemistry, Drug Carriers chemistry, Lung Neoplasms drug therapy
- Abstract
Cancer is one of the major diseases that cause a high number of deaths globally. Of the major types of cancers, lung cancer is known to be the most chronic form of cancer in the world. The conventional management of lung cancer includes different medical interventions like chemotherapy, surgical removal, and radiation therapy. However, this type of approach lacks specificity and also harms the adjacent normal cells. Lately, nanotechnology has emerged as a promising intervention in the management and treatment of lung cancers. Nanotechnology has revolutionized the existing modalities and focuses primarily on reducing toxicity and improving the bioavailability of anticancer drugs to the target tumor cells. Nanocarrier systems are being currently used extensively to exploit and to overcome the obstructions induced by cancers in the lungs. The nano-carrier-loaded therapeutic drug delivery methods have shown promising potential in treating lung cancer as its target is to control the growth of tumor cells. In this review, various modes of nano drug delivery options like liposomes, dendrimers, quantum dots, carbon nanotubes and metallic nanoparticles have been discussed. Nano-carrier drug delivery systems emerge as a promising approach and thus is expected to provide newer and advanced avenues in cancer therapeutics., (Copyright © 2019 Elsevier B.V. All rights reserved.)
- Published
- 2019
- Full Text
- View/download PDF
20. Oligonucleotide therapy: An emerging focus area for drug delivery in chronic inflammatory respiratory diseases.
- Author
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Mehta M, Deeksha, Tewari D, Gupta G, Awasthi R, Singh H, Pandey P, Chellappan DK, Wadhwa R, Collet T, Hansbro PM, Kumar SR, Thangavelu L, Negi P, Dua K, and Satija S
- Subjects
- Dendrimers chemistry, Humans, Liposomes chemistry, MicroRNAs chemistry, MicroRNAs therapeutic use, Nanoparticles chemistry, Oligonucleotides, Antisense chemistry, RNA Interference, RNA, Small Interfering chemistry, RNA, Small Interfering therapeutic use, Drug Carriers chemistry, Oligonucleotides, Antisense therapeutic use, Pulmonary Disease, Chronic Obstructive drug therapy
- Abstract
Oligonucleotide-based therapies are advanced novel interventions used in the management of various respiratory diseases such as asthma and Chronic Obstructive Pulmonary Disease (COPD). These agents primarily act by gene silencing or RNA interference. Better methodologies and techniques are the need of the hour that can deliver these agents to tissues and cells in a target specific manner by which their maximum potential can be reached in the management of chronic inflammatory diseases. Nanoparticles play an important role in the target-specific delivery of drugs. In addition, oligonucleotides also are extensively used for gene transfer in the form of polymeric, liposomal and inorganic carrier materials. Therefore, the current review focuses on various novel dosage forms like nanoparticles, liposomes that can be used efficiently for the delivery of various oligonucleotides such as siRNA and miRNA. We also discuss the future perspectives and targets for oligonucleotides in the management of respiratory diseases., (Copyright © 2019 Elsevier B.V. All rights reserved.)
- Published
- 2019
- Full Text
- View/download PDF
21. Interactions with the macrophages: An emerging targeted approach using novel drug delivery systems in respiratory diseases.
- Author
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Mehta M, Deeksha, Sharma N, Vyas M, Khurana N, Maurya PK, Singh H, Andreoli de Jesus TP, Dureja H, Chellappan DK, Gupta G, Wadhwa R, Collet T, Hansbro PM, Dua K, and Satija S
- Subjects
- Humans, Inflammation drug therapy, Drug Delivery Systems, Macrophages drug effects, Respiratory Tract Diseases drug therapy
- Abstract
Macrophages are considered as the most flexible cells of the hematopoietic system that are distributed in the tissues to act against pathogens and foreign particles. Macrophages are essential in maintaining homeostatic tissue processes, repair and immunity. Also, play important role in cytokine secretion and signal transduction of the infection so as to develop acquired immunity. Accounting to their involvement in pathogenesis, macrophages present a therapeutic target for the treatment of inflammatory respiratory diseases. This review focuses on novel drug delivery systems (NDDS) including nanoparticles, liposomes, dendrimers, microspheres etc that can target alveolar macrophage associated with inflammation, intracellular infection and lung cancer. The physiochemical properties and functional moieties of the NDDS attributes to enhanced macrophage targeting and uptake. The NDDS are promising for sustained drug delivery, reduced therapeutic dose, improved patient compliance and reduce drug toxicity. Further, the review also discuss about modified NDDS for specificity to the target and molecular targeting via anti-microbial peptides, kinases, NRF-2 and phosphodiesterase., (Copyright © 2019. Published by Elsevier B.V.)
- Published
- 2019
- Full Text
- View/download PDF
22. Increasing complexity and interactions of oxidative stress in chronic respiratory diseases: An emerging need for novel drug delivery systems.
- Author
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Dua K, Malyla V, Singhvi G, Wadhwa R, Krishna RV, Shukla SD, Shastri MD, Chellappan DK, Maurya PK, Satija S, Mehta M, Gulati M, Hansbro N, Collet T, Awasthi R, Gupta G, Hsu A, and Hansbro PM
- Subjects
- Anti-Inflammatory Agents chemistry, Anti-Inflammatory Agents pharmacology, Anti-Inflammatory Agents therapeutic use, Dendrimers chemistry, Drug Delivery Systems, Emulsions chemistry, Humans, Liposomes chemistry, Lung Diseases, Obstructive drug therapy, Lung Diseases, Obstructive metabolism, Microspheres, Nanoparticles chemistry, Lung Diseases, Obstructive pathology, Oxidative Stress drug effects
- Abstract
Oxidative stress is intensely involved in enhancing the severity of various chronic respiratory diseases (CRDs) including asthma, chronic obstructive pulmonary disease (COPD), infections and lung cancer. Even though there are various existing anti-inflammatory therapies, which are not enough to control the inflammation caused due to various contributing factors such as anti-inflammatory genes and antioxidant enzymes. This leads to an urgent need of novel drug delivery systems to combat the oxidative stress. This review gives a brief insight into the biological factors involved in causing oxidative stress, one of the emerging hallmark feature in CRDs and particularly, highlighting recent trends in various novel drug delivery carriers including microparticles, microemulsions, microspheres, nanoparticles, liposomes, dendrimers, solid lipid nanocarriers etc which can help in combating the oxidative stress in CRDs and ultimately reducing the disease burden and improving the quality of life with CRDs patients. These carriers improve the pharmacokinetics and bioavailability to the target site. However, there is an urgent need for translational studies to validate the drug delivery carriers for clinical administration in the pulmonary clinic., (Copyright © 2018 Elsevier B.V. All rights reserved.)
- Published
- 2019
- Full Text
- View/download PDF
23. Insertion of Dengue E into lipid bilayers studied by neutron reflectivity and molecular dynamics simulations.
- Author
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Vanegas JM, Heinrich F, Rogers DM, Carson BD, La Bauve S, Vernon BC, Akgun B, Satija S, Zheng A, Kielian M, Rempe SB, and Kent MS
- Subjects
- Amino Acid Sequence, Animals, Cells, Cultured, Hydrogen Bonding, Lipid Bilayers chemistry, Membrane Fusion, Models, Molecular, Molecular Dynamics Simulation, Neutrons, Protein Binding, Spodoptera, Viral Envelope Proteins chemistry, Virus Attachment, Lipid Bilayers metabolism, Viral Envelope Proteins metabolism, Virus Internalization
- Abstract
The envelope (E) protein of Dengue virus rearranges to a trimeric hairpin to mediate fusion of the viral and target membranes, which is essential for infectivity. Insertion of E into the target membrane serves to anchor E and possibly also to disrupt local order within the membrane. Both aspects are likely to be affected by the depth of insertion, orientation of the trimer with respect to the membrane normal, and the interactions that form between trimer and membrane. In the present work, we resolved the depth of insertion, the tilt angle, and the fundamental interactions for the soluble portion of Dengue E trimers (sE) associated with planar lipid bilayer membranes of various combinations of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC), 1-palmitoyl-2-oleoyl-sn-glycero-3-phospho-rac-glycerol (POPG), 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoethanolamine (POPE), and cholesterol (CHOL) by neutron reflectivity (NR) and by molecular dynamics (MD) simulations. The results show that the tip of E containing the fusion loop (FL) is located at the interface of the headgroups and acyl chains of the outer leaflet of the lipid bilayers, in good agreement with prior predictions. The results also indicate that E tilts with respect to the membrane normal upon insertion, promoted by either the anionic lipid POPG or CHOL. The simulations show that tilting of the protein correlates with hydrogen bond formation between lysines and arginines located on the sides of the trimer close to the tip (K246, K247, and R73) and nearby lipid headgroups. These hydrogen bonds provide a major contribution to the membrane anchoring and may help to destabilize the target membrane., (Copyright © 2018 Elsevier B.V. All rights reserved.)
- Published
- 2018
- Full Text
- View/download PDF
24. Supercritical fluid processing of polymer thin films: an X-ray study of molecular-level porosity.
- Author
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Koga T, Jerome J, Rafailovich MH, Chu B, Douglas J, and Satija S
- Abstract
This paper reviews our recent experimental results that address the effects of solvent density inhomogeneities in supercritical carbon dioxide (scCO(2)) on polymer thin film processing. The key phenomenon is excess sorption of CO(2) molecules into polymer thin films even when the bulk miscibility with CO(2) is very poor. We have found that the amount of the excess sorption is attributed to the large density fluctuations in scCO(2) near the critical point. Further, taking advantage of the vitrification process of polymer chains through quick evaporation of CO(2), we can preserve the "expanded" structures as they are. The resultant films have large degree of molecular-level porosity that is very useful in producing coatings with low dielectric constants, enhanced adhesion, and metallization properties. These characteristics can be achieved in an environmentally "green" manner, without organic solvents, and are not specific to any class of polymers.
- Published
- 2006
- Full Text
- View/download PDF
25. Influence of the electric field on a bio-mimetic film supported on a gold electrode.
- Author
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Burgess I, Li M, Horswell SL, Szymanski G, Lipkowski J, Satija S, and Majewski J
- Subjects
- Electrodes, Gold, Quartz, Biomimetic Materials, Cholesterol, Dimyristoylphosphatidylcholine, Electrochemistry, Lipid Bilayers
- Abstract
A model biological membrane was formed by fusion of mixed cholesterol and DMPC (dimyristoylphosphatidylcholine) phospholipid vesicles onto a gold-coated quartz support. The gold surface was charged and the influence of the charge at the solid support on the structure and integrity of the phospholipid bilayer was investigated using the specular reflection of neutrons and electrochemical measurements. When the surface charge density is close to zero, the lipid vesicles fuse directly on the surface to form a bilayer with a small number of defects and hence low water content. When the support's surface is negatively charged the film swells and incorporates water due to the field driven poration of the membrane. When the charge density is more negative then -8 microC cm(-2) the bilayer is detached from the metal surface. However, it remains in close proximity to the metal electrode, suspended on a thin cushion of water. The film thicknesses, calculated from neutron reflectivity, have allowed us to determine the tilt angle of the lipid molecules as a function of the support's charge density. The lipid molecules are tilted 55 degrees from the surface normal at zero charge density but become significantly more perpendicular (30 degrees tilt angle) at charge densities more negative than -8 microC cm(-2). The tilt angle measurements are in very good agreement with previous IR studies. This paper describes the highlights of a more in-depth study which is fully described in [1].
- Published
- 2005
- Full Text
- View/download PDF
26. Neutron and X-ray scattering studies of cholera toxin interactions with lipid monolayers at the air-liquid interface.
- Author
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Miller CE, Majewski J, Kjaer K, Weygand M, Faller R, Satija S, and Kuhl TL
- Subjects
- Cholera Toxin chemistry, G(M1) Ganglioside chemistry, G(M1) Ganglioside metabolism, Lipids chemistry, Neutron Diffraction, X-Ray Diffraction, Cholera Toxin metabolism, Lipid Metabolism
- Abstract
Using neutron/X-ray reflectivity and X-ray grazing incidence diffraction (GID), we have characterized the structure of mixed DPPE:GM(1) lipid monolayers before and during the binding of cholera toxin (CTAB(5)) or its B subunit (CTB(5)). Structural parameters such as the density and thickness of the lipid layer, extension of the GM(1) oligosaccharide headgroup, and orientation and position of the protein upon binding are reported. Both CTAB(5) and CTB(5) were measured to have approximately 50% coverage when bound to the lipid monolayer. X-ray GID experiments show that both the lipid monolayer and the cholera toxin layer are crystalline. The effects of X-ray beam damage have been assessed and the monolayer/toxin structure does not change with time after protein binding has saturated.
- Published
- 2005
- Full Text
- View/download PDF
27. Combustion Chemistry and the Carbon Neutral Future : What Will the Next 25 Years of Research Require?
- Author
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Kenneth Brezinsky and Kenneth Brezinsky
- Subjects
- Clean energy, Combustion
- Abstract
As the demands for cleaner, more efficient, reduced and zero carbon emitting transportation increase, the traditional focus of Combustion Chemistry research is stretching and adapting to help provide solutions to these contemporary issues. Combustion Chemistry and the Carbon Neutral Future: What will the Next 25 Years of Research Require? presents a guide to current research in the field and an exploration of possible future steps as we move towards cleaner, greener and reduced carbon combustion chemistry. Beginning with a discussion of engine emissions and soot, the book goes on to discuss a range of alternative fuels, including hydrogen, ammonia, small alcohols and other bio-oxygenates, natural gas, syngas and synthesized hydrocarbon fuels. Methods for predicting and improving efficiency and sustainability, such as low temperature and catalytic combustion, chemical looping, supercritical fluid combustion, and diagnostic monitoring even at high pressure, are then explored. Some novel aspects of biomass derived aviation fuels and combustion synthesis are also covered. Combining the knowledge and experience of an interdisciplinary team of experts in the field, Combustion Chemistry and the Carbon Neutral Future: What will the Next 25 Years of Research Require? is an insightful guide to current and future focus areas for combustion chemistry researchers in line with the transition to greener, cleaner technologies. - Provides insight on current developments in combustion chemistry as a tool for supporting a reduced-carbon future - Reviews modeling and diagnostic tools, in addition to key approaches and alternative fuels - Includes projections for the future from leaders in the field, pointing current and prospective researchers to potentially fruitful areas for exploration
- Published
- 2023
28. Fundamentals of Pharmacognosy and Phytotherapy E-Book : Fundamentals of Pharmacognosy and Phytotherapy E-Book
- Author
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Michael Heinrich, Joanne Barnes, José Prieto-Garcia, Simon Gibbons, Elizabeth M. Williamson, Michael Heinrich, Joanne Barnes, José Prieto-Garcia, Simon Gibbons, and Elizabeth M. Williamson
- Subjects
- Materia medica, Vegetable, Pharmacognosy
- Abstract
Pharmacognosy, the science of nature-derived drugs, pharmaceuticals and poisons, played a crucial role in the development of modern medicine, and now has an equally important place in healthcare all over the world. This wide scope ranges from traditional medicine systems and herbal and nutritional therapies, the preparation and use of highly standardised and clinically tested herbal medicines, to the production of potent drugs used only in a purified form. Natural sources mainly focus on plants, fungi and algae, but drug discovery of novel compounds and structures includes bacteria and even marine animals. Fundamentals of Pharmacognosy and Phytotherapy is a landmark textbook that covers this spectrum of medicinal plant use. Written by leading experts in this field, this book takes the reader through the history, identification and quality assurance of plant-based medicines to their therapeutic properties, safety and compatibility and interaction with prescribed drugs. Aimed at students of all healthcare professions, including pharmacy, medicine, nursing and complementary therapies, the comprehensively updated information in this textbook is also relevant to those companies and organisations concerned with the regulation and testing of herbal medicines (phytomedicines), other natural health products, nutraceuticals and dietary supplements. - Introduces the concepts and scope of pharmacognosy - Examines the scientific evidence of plant-based medicines for a range of health conditions - Extended and updated referencing includes recent reviews, WHO and official documents (open access where available) for quick access to further scientific literature New to this edition - Antimicrobial natural products: as antibiotics and antiseptics, and their potential as bacterial resistance modifiers - Anticancer natural products: scope now includes their role in chemoprevention and associated anti-inflammatory mechanisms - New chapter on pharmacovigilance for herbal medicines and related products - Quality assurance and pharmacopoeial methods extended, with many new figures and examples - Plant medicines of recent scientific interest (popularity, or notoriety) added throughout - An enhanced eBook version is included with purchase. The eBook allows you to access all the text, figures, and references, with the ability to search, customise your content, make notes and highlights, and have content read aloud - Antimicrobial natural products: as antibiotics and antiseptics, and their potential as bacterial resistance modifiers - Anticancer natural products: scope now includes their role in chemoprevention and associated anti-inflammatory mechanisms - New chapter on pharmacovigilance for herbal medicines and related products - Quality assurance and pharmacopoeial methods extended, with many new figures and examples - Plant medicines of recent scientific interest (popularity, or notoriety) added throughout
- Published
- 2023
29. Encyclopedia of Solid-Liquid Interfaces
- Abstract
Encyclopedia of Solid-Liquid Interfaces is designed to provide a comprehensive overview of macroscopic phenomena at solid-liquid interfaces, e.g. in physics, chemistry, geology, biology and technology, and to describe the methodological approaches and strategies to gain microscopic insight into the underlying properties and processes on the atomic/molecular level. Covering an area of chemistry that plays a fundamental role in nature and technology, the book compiles all relevant features of the field into a'one-stop'reference source that will be relevant to a wide range of interdisciplinary scientists, researchers and academics. Encompassing 155 chapters by renowned experts, and led by leading names in the field, the contents will be organized over 3 volumes. - Provides information on solid Liquid Interfaces that no other resource covers - Includes a comprehensive and interdisciplinary overview on current understanding of the ubiquitous phenomena at Solid-Liquid Interfaces in its full interdisciplinary breadth between physics, chemistry, biology and geology - Ideal resource to use in teaching, research and development that requires inputs on solid-liquid interfaces - Presents an up-to-date accounting of the experimental and theoretical research of solid-liquid interfaces at the atomic/molecular level as provided by expert authors
- Published
- 2023
30. Principles of Multiple-Liquid Separation Systems : Interaction, Application and Advancement
- Author
-
Kit Wayne Chew, Shir Reen Chia, Pau Loke Show, Kit Wayne Chew, Shir Reen Chia, and Pau Loke Show
- Subjects
- Separation (Technology), Liquids
- Abstract
Principles of Multiple-Liquid Separation Systems: Interaction, Application and Advancement describes the basic principles and advancements of multiple-liquid separation systems in downstream processing. Several important elements are included, such as the fundamental process and mechanisms of the multiple-liquid separation system, key principles of the interaction between different solvents and phase components, applications, and green solvents for the separation system. Furthermore, the book gives insights in commercializing this separation technique to industrial scale and making the process environmentally and economically sustainable. The book also presents constructive critics of this separation technique for both past and the latest findings. - Comprehensively reviews several advanced separation methods and their fundamentals in a single source - Covers a deep understanding of the interaction between various liquid phase techniques and the latest cases of advanced techniques applied in bioprocesses - Provides a critical and constructive judgement of costs and environmental sustainability of multiple-liquid separation systems
- Published
- 2023
31. Applications of Multifunctional Nanomaterials
- Author
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Sabu Thomas, Nandakumar Kalarikkal, Ann Rose Abraham, Sabu Thomas, Nandakumar Kalarikkal, and Ann Rose Abraham
- Abstract
Applications of Multifunctional Nanomaterials showcases the major applications of highly correlated nanosystems that highlight the multifunctionality of nanomaterials. This includes applications of nanomaterials in spintronics, information storage, magnetic data storage and memory device applications, energy harvesting applications using nanomultiferroics with piezoelectric polymers, nonlinear optical limiting applications using graphene or ferrite nanoparticles, soft tissues applications, EMI shielding applications and even applications in sunscreen lotions, cosmetics and food packaging will be discussed. In addition, nanoparticle incorporation in animal nutrition intended for increased productivity is an innovative and groundbreaking theme of the book. Finally, functionalized magnetic nanoparticles for drug delivery, magnetic hyperthermia, sutures, cancer therapy, dentistry and other biomedical and bio-engineering applications using nanoparticles are discussed in detail. - Explains the major design and fabrication techniques and processes for a range of multifunctional nanomaterials and nanotechnologies - Demonstrates how ferromagnetics, multiferroics and carbon nanomaterials are designed for electronic and optical applications - Assesses the major challenges of using multifunctional nanomaterials on a mass scale
- Published
- 2023
32. Antiviral and Antimicrobial Smart Coatings : Fundamentals and Applications
- Author
-
Aditya Kumar, Ajit Behera, Muhammad Bilal, Ram K. Gupta, Tuan Anh Nguyen, Aditya Kumar, Ajit Behera, Muhammad Bilal, Ram K. Gupta, and Tuan Anh Nguyen
- Subjects
- Anti-infective agents, Coatings
- Abstract
Antiviral and Antimicrobial Smart Coatings: Fundamentals and Applications provides a critical analysis of all types of smart antiviral and antimicrobial coatings currently being researched. The book opens with a discussion of the microbial and viral pathogens, including how to identify them and their interaction with surfaces. The next three sections look at the concept of smart coatings, specifically antibacterial, antifungal, and antiviral smart coatings, types, effects, and applications. The book concludes by discussing the methods and standards for characterization of coatings and then presents several real world case studies. A valuable resource for those working in the smart coatings field. - Introduces the concepts of smart coatings and the synthesis, characterization, and classification - Provides insights into the pros and cons of established processes and thereby provides guidance on how to select the appropriate techniques for specific applications - Discusses the process of applying smart antimicrobial and antiviral coatings on various surfaces - Presents the methods for characterization of smart and multifunctional coatings
- Published
- 2023
33. Nanostructured Materials for Tissue Engineering
- Author
-
Arijit Mondal, Amit Kumar Nayak, Prithviraj Chakraborty, Arijit Mondal, Amit Kumar Nayak, and Prithviraj Chakraborty
- Abstract
Nanostructured Materials for Tissue Engineering introduces the key properties and approaches involved in using nanostructured materials in tissue engineering, including functionalization, nanotechnology-based regenerative techniques, toxicological and biocompatible aspects. A broad range of nanomaterial types are covered, from polymer scaffolds and nanocomposites to gold nanoparticles and quantum dots. This book aids the reader in materials selection, as well as matching to the best applications, including bone, skin, pulmonary or neurological tissue engineering. Users will find this book to be an up-to-date review on this fast-changing field that is ideal for materials scientists, tissue engineers, biomedical engineers, and pharmaceutical scientists. - Covers the most recent advances in this fast-moving field, including all key aspects from properties and functionalization to materials selection and application in tissue engineering - Reviews a variety of nanomaterials and their benefits, including polymeric, gold and carbon nanoparticles - Explores a range of tissue engineering applications, such as cardiovascular therapies, skin repair and regeneration, and diabetes management
- Published
- 2023
34. Plant Polysaccharides As Pharmaceutical Excipients
- Author
-
Amit Kumar Nayak, Md Saquib Hasnain, Dilipkumar Pal, Amit Kumar Nayak, Md Saquib Hasnain, and Dilipkumar Pal
- Subjects
- Polysaccharides--Therapeutic use, Excipients
- Abstract
Plant Polysaccharides as Pharmaceutical Excipients explores innovative techniques and applications of plant-derived polysaccharides as pharmaceutical excipients. Plant polysaccharides are sustainable, renewable and abundantly available, offering attractive properties in terms of water solubility, swelling ability, non-toxicity and biodegradability. These qualities have resulted in extensive exploration into their applications as excipients in a variety of pharmaceutical dosage forms. This book takes a comprehensive, application-oriented approach, drawing on the very latest research that includes sources, classification and extraction methods of plant polysaccharides. Subsequent chapters focus on plant polysaccharides for individual pharmaceutical applications, enabling the reader to understand their preparation for specific targeted uses. Throughout the book, information is supported by illustrations, chemical structures, flow charts and data tables, providing a clear understanding. Finally, future perspectives and challenges are reviewed and discussed. - Explains sources, classifications, extraction methods and biocompatibility of plant polysaccharides - Guides the reader through properties and preparation methods of plant polysaccharides as pharmaceutical excipients - Covers a broad range of cutting-edge applications, with each chapter targeting a specific use
- Published
- 2023
35. Fungal Cell Factories for Sustainable Nanomaterials Productions and Agricultural Applications
- Author
-
Kamel A Abd-Elsalam and Kamel A Abd-Elsalam
- Abstract
Fungal Cell Factories for Sustainable Nanomaterials Productions and Agricultural Applications explores the mycogenic synthesis of many metal nanoparticles, including processing processes, environmental protection, and future perspectives. Nanomaterials, including silver, gold, palladium, copper, zinc, selenium, titanium dioxide, metal sulphide, cellulose, have been formed by major fungal genes, such as mushrooms, Fusarium, Trichoderma, endophytic fungi, and yeast, in addition to lichens. Understanding the exact process involved in the synthesis of nanoparticles and the effects of various factors on the reduction of metal ions can help to improve low-cost strategies for the synthesis and extraction of nanoparticles. Other sections focus on a new framework for the production of nano-antimicrobial, the use of myconanoparticles against plant diseases, post-harvest antibiotics, mycotoxin control and plant pests in addition to certain animal pathogens. Myconanomaterials are well developed with great potential and promise for advanced diagnostics, biosensors, precision farming and targeted smart delivery systems. - Assesses the impact of a variety of copper-based nanostructures on agri-food sectors, addressing the most relevant knowledge gaps - Explores the opportunities that myconanotechnology can provide for industrial applications - Explains the major challenges of applying myconanotechnology at an industrial scale
- Published
- 2022
36. Nanotechnology and Human Health : Current Research and Future Trends
- Author
-
Mukesh Kumar Yadav, Jae Jun Song, Arun S. Kharat, Punuri Jayasekhar Babu, Mukesh Kumar Yadav, Jae Jun Song, Arun S. Kharat, and Punuri Jayasekhar Babu
- Subjects
- Biotechnology, Nanotechnology--Health aspects
- Abstract
Nanotechnology in Human Health: Current Research and Future Trends details the various challenges faced in human healthcare settings and how nanotechnology can be used to target and improve outcomes. The book describes the application of nanoparticles in the diagnosis of human diseases, including metabolic diseases, cancer, bacterial infection, organ degeneration and the various targeted, nano-based treatments available. Several chapters look at how microbial biofilms - a key clinical concern - can be mitigated using nanomaterials and nanotechnology. In addition, the book covers how different nanoparticle types can be utilized as therapeutic agents. This book combines materials science concepts and techniques with clinical insights and understanding to provide an interdisciplinary reference for materials scientists, microbiologists, biomedical engineers and clinicians with an interest in nanotechnology. - Reviews the potential applications of nanotechnology in healthcare, with a focus on combating antibiotic-resistant microbial infections and biofilms - Explores the legal, social and ethical challenges of utilizing nanotechnology in clinical settings - Combines materials science concepts and techniques with clinical insights and understanding to provide an interdisciplinary approach
- Published
- 2022
37. Copper Nanostructures: Next-Generation of Agrochemicals for Sustainable Agroecosystems
- Author
-
Kamel A Abd-Elsalam and Kamel A Abd-Elsalam
- Subjects
- Copper in agriculture, Sustainable agriculture, Nanostructured materials--Environmental aspects, Agricultural chemicals
- Abstract
Copper Nanostructures: Next-Generation of Agrochemicals for Sustainable Agroecosystems considers the impact of copper-based nanostructures on agri-food sectors. Sections highlight the green synthesis of copper nanoparticles, production mechanisms, eco-safety, and future perspectives, discuss the increasing importance of copper nanomaterials in plant protection applications, describe the use of copper nanostructures in plant science applications, cover antimicrobial applications, explore copper nanostructure applications, and summarize current applications in agroecosystems, such as copper nanoparticles as nanosensors, their negative ecological effects, estimation risks, and more. - Assesses the impact of a large variety of copper-based nanostructures on the agri-food sector - Discusses how the properties of a variety of copper-based nanomaterials make them effective for agricultural applications - Explains the challenges surrounding the mass production of copper-based nanomaterials
- Published
- 2022
38. Fundamentals of Bionanomaterials
- Author
-
Ahmed Barhoum, Jaison Jeevanandam, Michael K Danquah, Ahmed Barhoum, Jaison Jeevanandam, and Michael K Danquah
- Abstract
Bionanomaterials are molecular materials composed partially or completely of biological molecules, key biological structures, such as proteins, enzymes, viruses, DNA, biopolymers as well as metal, metal oxides, and carbon nanomaterials with characteristic bioactivity. Bionanomaterials have drawn much attention for their use in a wide range of industrial applications from scaffolds, dental implants, drug delivery, dialysis, biobatteries, biofuel cells, air purification, and water treatment. Therefore, the intensive current research in this area is driven towards the designing and functionalization of bionanomaterials for industrial applications. Fundamentals of Bionanomaterials covers the fundamental aspects, experimental setup, synthesis, properties, and characterization of the different types of bionanomaterial. It discusses the different structure and unique properties of bionanomaterials that can be obtained by modifying their morphology and composition, highlighting a wide range of fabrication techniques of bionanomaterials and critical processing parameters. This is an important reference source for all those seeking to gain a solid understanding of the characterization, properties and processing a variety of bionanomaterial classes. - Explains the major properties and characterization techniques for a range of bionanomaterial classes - Discusses the commercialization of different types of bionanomaterials for a variety of industry sectors - Highlights the challenges and interdisciplinary perspective of bionanomaterials in science, biology, engineering, medicine, and technology, incorporating both fundamentals and applications
- Published
- 2022
39. Freshwater Mycology : Perspectives of Fungal Dynamics in Freshwater Ecosystems
- Author
-
Suhaib A. Bandh, Sana Shafi, Suhaib A. Bandh, and Sana Shafi
- Subjects
- Freshwater fungi
- Abstract
Freshwater Mycology: Perspectives of Fungal Dynamics in Freshwater Ecosystems presents chapters from expert contributors around the world. Through the contributed chapters, the contributors explore the perspectives of fungal dynamics in freshwater ecosystems, especially their diversity, distribution, functioning and role, biotransformation and bioprospecting potential, methodical advancements and metagenomic insights. Written with aquatic ecologists in mind, this book provides information on oceanic, estuarine and freshwater ecosystems not currently well understood and identifies new questions and answers about the roles of mycology in aquatic ecosystems. This topic is becoming an increasingly important area to understand due to the increasing global transports of microbes due to climate change and human actions. This is leading to a rapid loss of healthy freshwater ecosystems, the grave problem of antibiotic resistance, and the rarity of qualified mycology taxonomists and molecular systematicians. - Includes data from locations not previously or well covered from prior synthesis publications - Identifies new information on the roles of mycology in aquatic ecosystems - Provides insights into the fungal diversity of freshwater ecosystems, along with their potential roles
- Published
- 2022
40. Agri-Waste and Microbes for Production of Sustainable Nanomaterials
- Author
-
Kamel A. Abd-Elsalam, Rajiv Periakaruppan, S. Rajeshkumar, Kamel A. Abd-Elsalam, Rajiv Periakaruppan, and S. Rajeshkumar
- Subjects
- Agricultural wastes--Recycling, Nanostructured materials--Environmental aspects
- Abstract
Agri-Waste and Microbes for Production of Sustainable Nanomaterials assesses the most recent trends used to produce bionanomaterials from agricultural waste and microorganisms. The book covers the green synthesis of various nanomaterials using microorganisms and agricultural waste, including the synthesis and characterization of green nanomaterials, the production of nanomaterials from agri-waste, including metallic, copper, silica, cellulose, nanopolymers and nano/micro plastics, and biological methods such as agricultural and microbial synthesis of metallic/metal oxide, magnetic, silver, copper, nanomaterials and nanonutrients. This is an important reference source for plant scientists, materials scientists and environmental scientists who want to understand this new generation of sustainable nanomaterials. The synthesis of nanocellulose materials from agri-wastes is an emerging alternative for waste treatment methods, developing new biosensors and antimicrobial agents. Silicon nanoparticles are an additional ingredient for the improvement of crop yields. With recent advances in nanomaterials synthesis performance and the discovery of their biomedical, environmental and agricultural applications, it is hoped that the implementation of these methods will be used at large-scale for industrial applications in different sectors. - Highlights recent methods to produce bionanomaterials from agricultural waste and microorganisms - Explores the use of agri-waste in environmental and agricultural applications - Assesses the major challenges for using agri-waste to create eco-friendly nanomaterials at large scale
- Published
- 2022
41. Nanotechnology in Modern Animal Biotechnology : Concepts and Applications
- Author
-
Pawan Kumar Maurya, Sanjay Singh, Pawan Kumar Maurya, and Sanjay Singh
- Subjects
- Biotechnology industries, Biotechnology, Nanotechnology
- Abstract
Nanotechnology in Modern Animal Biotechnology: Concepts and Applications discusses the advancement of nanotechnologies in almost every field, ranging from materials science, to food, forensic, agriculture and life sciences, including biotechnology and medicine. Nanotechnology is already being harnessed to address many of the key problems in animal biotechnology, with future applications covering animal biotechnology (e.g. animal nutrition, health, disease diagnosis, and drug delivery). This book provides the tools, ideas and techniques of nanoscale principles to investigate, understand and transform biological systems. Nanotechnology provides the ability to manipulate materials at atomic and molecular levels and also arrange atom-by-atom on a scale of ~1–100 nm to create, new materials and devices with fundamentally new functions and properties arising due to their small scale. - Details the basics of nanotechnology, along with comprehensive information on the state-of-the-art and future perspectives of nanotechnology in biosensors - Provides recent perspectives and the challenges of nanomedicine - Provides new insights into the role nanomaterials can play in curing various diseases - Includes the most recent diagnostic methods, such as nanosensors
- Published
- 2019
42. Comprehensive Biomaterials II
- Author
-
Kevin Healy, Dietmar W. Hutmacher, David W. Grainger, C. James Kirkpatrick, Kevin Healy, Dietmar W. Hutmacher, David W. Grainger, and C. James Kirkpatrick
- Subjects
- Biomedical materials
- Abstract
Comprehensive Biomaterials II, Second Edition, Seven Volume Set brings together the myriad facets of biomaterials into one expertly-written series of edited volumes. Articles address the current status of nearly all biomaterials in the field, their strengths and weaknesses, their future prospects, appropriate analytical methods and testing, device applications and performance, emerging candidate materials as competitors and disruptive technologies, research and development, regulatory management, commercial aspects, and applications, including medical applications. Detailed coverage is given to both new and emerging areas and the latest research in more traditional areas of the field. Particular attention is given to those areas in which major recent developments have taken place. This new edition, with 75% new or updated articles, will provide biomedical scientists in industry, government, academia, and research organizations with an accurate perspective on the field in a manner that is both accessible and thorough. - Reviews the current status of nearly all biomaterials in the field by analyzing their strengths and weaknesses, performance, and future prospects - Covers all significant emerging technologies in areas such as 3D printing of tissues, organs and scaffolds, cell encapsulation; multimodal delivery, cancer/vaccine - biomaterial applications, neural interface understanding, materials used for in situ imaging, and infection prevention and treatment - Effectively describes the many modern aspects of biomaterials from basic science, to clinical applications
- Published
- 2017
43. Comprehensive Supramolecular Chemistry II
- Author
-
George W. Gokel, Len Barbour, George W. Gokel, and Len Barbour
- Subjects
- Supramolecular chemistry
- Abstract
Comprehensive Supramolecular Chemistry II, Second Edition, Nine Volume Set is a'one-stop shop'that covers supramolecular chemistry, a field that originated from the work of researchers in organic, inorganic and physical chemistry, with some biological influence. The original edition was structured to reflect, in part, the origin of the field. However, in the past two decades, the field has changed a great deal as reflected in this new work that covers the general principles of supramolecular chemistry and molecular recognition, experimental and computational methods in supramolecular chemistry, supramolecular receptors, dynamic supramolecular chemistry, supramolecular engineering, crystallographic (engineered) assemblies, sensors, imaging agents, devices and the latest in nanotechnology. Each section begins with an introduction by an expert in the field, who offers an initial perspective on the development of the field. Each article begins with outlining basic concepts before moving on to more advanced material. - Contains content that begins with the basics before moving on to more complex concepts, making it suitable for advanced undergraduates as well as academic researchers - Focuses on application of the theory in practice, with particular focus on areas that have gained increasing importance in the 21st century, including nanomedicine, nanotechnology and medicinal chemistry - Fully rewritten to make a completely up-to-date reference work that covers all the major advances that have taken place since the First Edition published in 1996
- Published
- 2017
44. Polymer Green Flame Retardants
- Author
-
Constantine D. Papaspyrides, Pantelis Kiliaris, Constantine D. Papaspyrides, and Pantelis Kiliaris
- Subjects
- Polymers--Fires and fire prevention
- Abstract
Polymer Green Flame Retardants covers key issues regarding the response of polymers during fire, the mechanisms of their flame retardation, the regulations imposed on their use, and the health hazards arising from their combustion. Presenting the latest research developments, the book focuses in particular on nanocomposites, believed to be the most promising approach for producing physically superior materials with low flammability and ecological impact. The fire properties of nanocomposites of various matrixes and fillers are discussed, the toxicological characteristics of these materials are analyzed, addressing also their environmental sustainability. Edited by distinguished scientists, including an array of international industry and academia experts, this book will appeal to chemical, mechanical, environmental, material and process engineers, upper-level undergraduate and graduate students in these disciplines, and generally to researchers developing commercially attractive and environmentally friendly fire-proof products. - Provides recent findings on the manufacture of environmentally sustainable flame retardant polymeric materials - Covers legislation and regulations concerning flame retarded polymeric material use - Includes tables containing the fire properties of the most common polymeric materials
- Published
- 2014
45. Side Effects of Drugs Annual : A Worldwide Yearly Survey of New Data and Trends in Adverse Drug Reactions
- Author
-
Jeffrey K. Aronson and Jeffrey K. Aronson
- Subjects
- Pharmacology, Drugs--Side effects
- Abstract
The Side Effects of Drugs Annual was first published in 1977. It has been continually published since then, as a yearly update to the voluminous encyclopedia Meyler's Side Effects of Drugs. Each new Annual continues to provide clinicians and medical investigators with a reliable and critical yearly survey of new data and trends in the area of Adverse Drug Reactions and Interactions. An international team of specialists has contributed to the informative, by critically interpreting it, and by pointing to whatever is misleading. - Provides a critical yearly survey of new data and trends - Special reviews in this Annual include, among other topics, Epidemiology of the use of ecstasy, Paracetamol and the risk of asthma, Combination vaccines/multiple immunizations, Interactions of herbal medicines with warfarin, and Tyrosine kinase inhibitors
- Published
- 2010
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