516 results on '"Sasaki, K"'
Search Results
2. Temperature effect on strength of aluminum based high thermal conductive composites containing VGCF-CNT filler
- Author
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Sasaki, K., primary, Fukuchi, K., additional, Imanishi, T., additional, and Kakitsuji, A., additional
- Published
- 2014
- Full Text
- View/download PDF
3. ANALYTICAL AND EXPERIMENTAL MODELING OF INTRA-BODY COMMUNICATION CIRCUIT
- Author
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Terauchi, Y., primary, Hachisuka, K., additional, Sasaki, K., additional, Kishi, Y., additional, Hirota, T., additional, Hosaka, H., additional, Fujii, K., additional, and Ito, K., additional
- Published
- 2007
- Full Text
- View/download PDF
4. DEVELOPMENT OF LOCAL POSITIONING SYSTEM USING BLUETOOTH
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Hirota, T., primary, Tanaka, S., additional, Iwasaki, T., additional, Hosaka, H., additional, Sasaki, K., additional, Enomoto, M., additional, and Ando, H., additional
- Published
- 2007
- Full Text
- View/download PDF
5. O-Glycosidation Methods
- Author
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Toshima, K., primary and Sasaki, K., additional
- Published
- 2007
- Full Text
- View/download PDF
6. Normal transition in YBCO thin film and its effect on current limiting characteristics
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Onishi, T., primary, Sasaki, K., additional, and Kayoda, T., additional
- Published
- 2005
- Full Text
- View/download PDF
7. Characteristics of CO2 gas permeability and adsorption of coal samples for CO2 sequestration into Japanese coal seams
- Author
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SASAKI, K, primary and FUJII, T, additional
- Published
- 2005
- Full Text
- View/download PDF
8. Chemistry and Biological Activities of Ginkgo Biloba
- Author
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Sasaki, K., primary, Wada, K., additional, and Haga, M., additional
- Published
- 2003
- Full Text
- View/download PDF
9. Fundamental Tests on Carbon Dioxide Sequestration Into Coal Seams
- Author
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OHGA, K, primary, SASAKI, K, additional, DEGUCHI, G, additional, and FUJIOKA, M, additional
- Published
- 2003
- Full Text
- View/download PDF
10. Hydrogen and poly- (hydroxy) alkanoate production from organic acids by photosynthetic bacteria
- Author
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Noparatnaraporn, N., primary, Takeno, K., additional, and Sasaki, K., additional
- Published
- 2001
- Full Text
- View/download PDF
11. UNIFIED APPROACH TO CONSTITUTIVE MODELING -PLASTICITY AND CREEP-
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Ishikawa, H., primary and Sasaki, K., additional
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- 1996
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12. CYCLIC DEFORMATION AND LIFE PREDICTION OF SN-PB SOLDER ALLOYS
- Author
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Ohguchi, K., primary, Ishikawa, H., additional, and Sasaki, K., additional
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- 1996
- Full Text
- View/download PDF
13. Multivariable Control of a Magnetic Levitation System with a Y Shape Iron Plate
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Fujii, T., primary, Tsujino, T., additional, Suematu, K., additional, Sasaki, K., additional, and Murata, Y., additional
- Published
- 1995
- Full Text
- View/download PDF
14. Analysis of operator's diagnostic behavior using computer simulation
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Furuta, K., primary, Takahashi, M., additional, Yoshikawa, H., additional, Sasaki, K., additional, Itoh, T., additional, Matsumiya, M., additional, Sakaue, T., additional, Kiyokawa, K., additional, and Hasegawa, A., additional
- Published
- 1995
- Full Text
- View/download PDF
15. Consideration on acceleration mechanism of two dimensional MPD thruster
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Sasaki, K., primary, Hikita, Y., additional, Kawaguchi, H., additional, and Honma, T., additional
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- 1995
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- View/download PDF
16. Optical harmony of microparticles in solution
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Kitamura, N., primary, Sasaki, K., additional, Misawa, H., additional, and Masuhara, H., additional
- Published
- 1994
- Full Text
- View/download PDF
17. Poled polymer Frequency Doubling Waveguide in Purple-blue Wavelength Region
- Author
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Kinoshita, T., primary, Nonaka, Y., additional, Nihei, E., additional, Koike, Y., additional, and Sasaki, K., additional
- Published
- 1992
- Full Text
- View/download PDF
18. Application of Hybrid Constitutive Model to Sinusoidal Loading
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Sasaki, K., primary and Ishikawa, H., additional
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- 1992
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- View/download PDF
19. Application of Liquid Membrane Technique to the Recovery if Fermented Organic Acids
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HANO, T., primary, MATSUMOTO, M., additional, OHTAKE, T., additional, SASAKI, K., additional, HORI, F., additional, and KAWANO, Y., additional
- Published
- 1992
- Full Text
- View/download PDF
20. VARIOUS FACTORS AFFECTING THRESHOLD ENERGY PRODUCING A (n,γ)-PRODUCED HOT ATOM
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MATSUURA, T., primary, HIROTA, R., additional, and SASAKI, K., additional
- Published
- 1991
- Full Text
- View/download PDF
21. Formation of Functionally Gradient Diamond Films
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Kurihara, K., primary, Sasaki, K., additional, Kawarada, M., additional, and Goto, Y., additional
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- 1991
- Full Text
- View/download PDF
22. Electrical and morphological change of Ag-Ni films by annealing in vacuum
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Kawamura, M., Yamaguchi, M., Abe, Y., and Sasaki, K.
- Subjects
ComputingMethodologies_DOCUMENTANDTEXTPROCESSING - Abstract
Ag and Ag-Ni films (Ni: 0.6, 2.0 and 4.8 at.%) with a thickness of 95 nm were deposited on SiO_2/Si substrates and the thermal stability of the films was evaluated. The films were annealed at temperatures from 500 to 700℃ for 1 hour in vacuum. The as-deposited Ag and Ag-Ni films had a smooth surface. The Ag-Ni films had an electrical resistivity higher than that of the Ag film because of the impurity scattering effect. However, the resistivity of Ag-Ni films decreased until 600℃ by annealing. As the morphological change after annealing, void formation was observed for the Ag film at 500℃. Then after the annealing at 600℃, agglomeration with a partly uncovered substrate was clearly observed for the Ag film. On the other hand, void formation was also observed for the Ag-Ni films at 600℃. Further annealing at 650℃ caused agglomeration of the Ag-Ni films with an increase in their resistivity. Due to the insolubility of Ni into Ag, small islands of Ni appeared at this temperature. Consequently, Ag-Ni films are useful suppressing agglomeration up to the annealing temperature of 600℃. The resistivity of the Ag-Ni (0.6 at.%) film was 2.1-2.4μΩcm after annealing from 400℃ to 550℃ comparable with that of the Ag film (1.9-2.2μΩcm) and it remained low, though that of the pure Ag film increased significantly at 600℃., application/pdf
- Published
- 2005
23. Characterization of thermally stable Ir-Ta alloy thin films deposited by sputtering
- Author
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Watanabe, E., Abe, Y., Sasaki, K., and Iura, S.
- Subjects
ComputingMethodologies_DOCUMENTANDTEXTPROCESSING - Abstract
Ir-Ta alloy thin films were deposited on Si0_2/Si substrates by a magnetron sputtering system using pure Ar as sputtering gas. The lr/Ta composition ratio of the alloy films was varied by changing the number of Ta chips on an lr target. The crystal structure of the alloy films changed from fcc-Ir to lr_3Ta, α-(Ir,Ta), Ta_3Ir, and bcc-Ta with increasing Ta content. Post-deposition annealing of the alloy films was carried out in oxygen at temperatures from 300℃ to 800℃ for 1 hour. The alloy films with Ta contents of 10-50 at.% indicated low electrical resistivities below 220 μΩcm and the low resistivities were remained after annealing up to 600℃., application/pdf
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- 2004
24. Formation process of Al2O3 thin films by reactive sputtering
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Chiba, Y, Abe, Y, Kawamura, M, and Sasaki, K
- Subjects
Reactive sputtering ,Gettering effect ,Target voltage ,Aluminum oxide ,Plasma emission intensity - Abstract
Al and Al2O3 films were deposited by RF magnetron sputtering using a mixed gas of Ar and O2. The surface of the Al target was changed from the metallic mode to the oxide mode at a critical O2 flow ratio of 8%. The atomic ratio of sputtered Al atoms to supplied oxygen atoms was found to be approximately 2:3 at the critical O2 flow ratio. The oxide layer thickness formed on the Al target was estimated to be 5?7 nm at an O2 flow ratio of 100% by ellipsometry.
- Published
- 2008
25. The T2K experiment
- Author
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Abe, K., Abgrall, N., Aihara, H., Ajima, Y., Albert, J.B., Allan, D., Amaudruz, P.-A., Andreopoulos, C., Andrieu, B., Anerella, M.D., Angelsen, C., Aoki, S., Araoka, O., Argyriades, J., Ariga, A., Ariga, T., Assylbekov, S., de André, J.P.A.M., Autiero, D., Badertscher, A., Ballester, O., Barbi, M., Barker, G.J., Baron, P., Barr, G., Bartoszek, L., Batkiewicz, M., Bay, F., Bentham, S., Berardi, V., Berger, B.E., Berns, H., Bertram, I., Besnier, M., Beucher, J., Beznosko, D., Bhadra, S., Birney, P., Bishop, D., Blackmore, E., Blaszczyk, F.d.M., Blocki, J., Blondel, A., Bodek, A., Bojechko, C., Bouchez, J., Boussuge, T., Boyd, S.B., Boyer, M., Braam, N., Bradford, R., Bravar, A., Briggs, K., Brinson, J.D., Bronner, C., Brook-Roberge, D.G., Bryant, M., Buchanan, N., Budd, H., Cadabeschi, M., Calland, R.G., Calvet, D., Caravaca Rodríguez, J., Carroll, J., Cartwright, S.L., Carver, A., Castillo, R., Catanesi, M.G., Cavata, C., Cazes, A., Cervera, A., Charrier, J.P., Chavez, C., Choi, S., Chollet, S., Christodoulou, G., Colas, P., Coleman, J., Coleman, W., Collazuol, G., Connolly, K., Cooke, P., Curioni, A., Dabrowska, A., Danko, I., Das, R., Davies, G.S., Davis, S., Day, M., De La Broise, X., de Perio, P., De Rosa, G., Dealtry, T., Debraine, A., Delagnes, E., Delbart, A., Densham, C., Di Lodovico, F., Di Luise, S., Dinh Tran, P., Dobson, J., Doornbos, J., Dore, U., Drapier, O., Druillole, F., Dufour, F., Dumarchez, J., Durkin, T., Dytman, S., Dziewiecki, M., Dziomba, M., Ellison, B., Emery, S., Ereditato, A., Escallier, J.E., Escudero, L., Esposito, L.S., Faszer, W., Fechner, M., Ferrero, A., Finch, A., Fisher, C., Fitton, M., Flight, R., Forbush, D., Frank, E., Fransham, K., Fujii, Y., Fukuda, Y., Gallop, M., Galymov, V., Ganetis, G.L., Gannaway, F.C., Gaudin, A., Gaweda, J., Gendotti, A., George, M., Giffin, S., Giganti, C., Gilje, K., Giomataris, I., Giraud, J., Ghosh, A.K., Golan, T., Goldhaber, M., Gomez-Cadenas, J.J., Gomi, S., Gonin, M., Goyette, M., Grant, A., Grant, N., Grañena, F., Greenwood, S., Gumplinger, P., Guzowski, P., Haigh, M.D., Hamano, K., Hansen, C., Hara, T., Harrison, P.F., Hartfiel, B., Hartz, M., Haruyama, T., Hasanen, R., Hasegawa, T., Hastings, N.C., Hastings, S., Hatzikoutelis, A., Hayashi, K., Hayato, Y., Haycock, T.D.J., Hearty, C., Helmer, R.L., Henderson, R., Herlant, S., Higashi, N., Hignight, J., Hiraide, K., Hirose, E., Holeczek, J., Honkanen, N., Horikawa, S., Hyndman, A., Ichikawa, A.K., Ieki, K., Ieva, M., Iida, M., Ikeda, M., Ilic, J., Imber, J., Ishida, T., Ishihara, C., Ishii, T., Ives, S.J., Iwasaki, M., Iyogi, K., Izmaylov, A., Jamieson, B., Johnson, R.A., Joo, K.K., Jover-Manas, G., Jung, C.K., Kaji, H., Kajita, T., Kakuno, H., Kameda, J., Kaneyuki, K., Karlen, D., Kasami, K., Kasey, V., Kato, I., Kawamuko, H., Kearns, E., Kellet, L., Khabibullin, M., Khaleeq, M., Khan, N., Khotjantsev, A., Kielczewska, D., Kikawa, T., Kim, J.Y., Kim, S.-B., Kimura, N., Kirby, B., Kisiel, J., Kitching, P., Kobayashi, T., Kogan, G., Koike, S., Komorowski, T., Konaka, A., Kormos, L.L., Korzenev, A., Koseki, K., Koshio, Y., Kouzuma, Y., Kowalik, K., Kravtsov, V., Kreslo, I., Kropp, W., Kubo, H., Kubota, J., Kudenko, Y., Kulkarni, N., Kurchaninov, L., Kurimoto, Y., Kurjata, R., Kurosawa, Y., Kutter, T., Lagoda, J., Laihem, K., Langstaff, R., Laveder, M., Lawson, T.B., Le, P.T., Le Coguie, A., Le Ross, M., Lee, K.P., Lenckowski, M., Licciardi, C., Lim, I.T., Lindner, T., Litchfield, R.P., Longhin, A., Lopez, G.D., Lu, P., Ludovici, L., Lux, T., Macaire, M., Magaletti, L., Mahn, K., Makida, Y., Malafis, C.J., Malek, M., Manly, S., Marchionni, A., Mark, C., Marino, A.D., Marone, A.J., Marteau, J., Martin, J.F., Maruyama, T., Maryon, T., Marzec, J., Masliah, P., Mathie, E.L., Matsumura, C., Matsuoka, K., Matveev, V., Mavrokoridis, K., Mazzucato, E., McCauley, N., McFarland, K.S., McGrew, C., McLachlan, T., Mercer, I., Messina, M., Metcalf, W., Metelko, C., Mezzetto, M., Mijakowski, P., Miller, C.A., Minamino, A., Mineev, O., Mine, S., Minvielle, R.E., Mituka, G., Miura, M., Mizouchi, K., Mols, J.-P., Monfregola, L., Monmarthe, E., Moreau, F., Morgan, B., Moriyama, S., Morris, D., Muir, A., Murakami, A., Muratore, J.F., Murdoch, M., Murphy, S., Myslik, J., Nagashima, G., Nakadaira, T., Nakahata, M., Nakamoto, T., Nakamura, K., Nakayama, S., Nakaya, T., Naples, D., Nelson, B., Nicholls, T.C., Nishikawa, K., Nishino, H., Nitta, K., Nizery, F., Nowak, J.A., Noy, M., Obayashi, Y., Ogitsu, T., Ohhata, H., Okamura, T., Okumura, K., Okusawa, T., Ohlmann, C., Olchanski, K., Openshaw, R., Oser, S.M., Otani, M., Owen, R.A., Oyama, Y., Ozaki, T., Pac, M.Y., Palladino, V., Paolone, V., Paul, P., Payne, D., Pearce, G.F., Pearson, C., Perkin, J.D., Pfleger, M., Pierre, F., Pierrepont, D., Plonski, P., Poffenberger, P., Poplawska, E., Popov, B., Posiadala, M., Poutissou, J.-M., Poutissou, R., Preece, R., Przewlocki, P., Qian, W., Raaf, J.L., Radicioni, E., Ramos, K., Ratoff, P., Raufer, T.M., Ravonel, M., Raymond, M., Retiere, F., Richards, D., Ritou, J.-L., Robert, A., Rodrigues, P.A., Rondio, E., Roney, M., Rooney, M., Ross, D., Rossi, B., Roth, S., Rubbia, A., Ruterbories, D., Sacco, R., Sadler, S., Sakashita, K., Sanchez, F., Sarrat, A., Sasaki, K., Schaack, P., Schmidt, J., Scholberg, K., Schwehr, J., Scott, M., Scully, D.I., Seiya, Y., Sekiguchi, T., Sekiya, H., Sheffer, G., Shibata, M., Shimizu, Y., Shiozawa, M., Short, S., Siyad, M., Smith, D., Smith, R.J., Smy, M., Sobczyk, J., Sobel, H., Sooriyakumaran, S., Sorel, M., Spitz, J., Stahl, A., Stamoulis, P., Star, O., Statter, J., Stawnyczy, L., Steinmann, J., Steffens, J., Still, B., Stodulski, M., Stone, J., Strabel, C., Strauss, T., Sulej, R., Sutcliffe, P., Suzuki, A., Suzuki, K., Suzuki, S., Suzuki, S.Y., Suzuki, Y., Swierblewski, J., Szeglowski, T., Szeptycka, M., Tacik, R., Tada, M., Tadepalli, A.S., Taguchi, M., Takahashi, S., Takeda, A., Takenaga, Y., Takeuchi, Y., Tanaka, H.A., Tanaka, K., Tanaka, M., Tanaka, M.M., Tanimoto, N., Tashiro, K., Taylor, I.J., Terashima, A., Terhorst, D., Terri, R., Thompson, L.F., Thorley, A., Thorpe, M., Toki, W., Tomaru, T., Totsuka, Y., Touramanis, C., Tsukamoto, T., Tvaskis, V., Tzanov, M., Uchida, Y., Ueno, K., Usseglio, M., Vacheret, A., Vagins, M., Van Schalkwyk, J.F., Vanel, J.-C., Vasseur, G., Veledar, O., Vincent, P., Wachala, T., Waldron, A.V., Walter, C.W., Wanderer, P.J., Ward, M.A., Ward, G.P., Wark, D., Warner, D., Wascko, M.O., Weber, A., Wendell, R., Wendland, J., West, N., Whitehead, L.H., Wikström, G., Wilkes, R.J., Wilking, M.J., Williamson, Z., Wilson, J.R., Wilson, R.J., Wong, K., Wongjirad, T., Yamada, S., Yamada, Y., Yamamoto, A., Yamamoto, K., Yamanoi, Y., Yamaoka, H., Yanagisawa, C., Yano, T., Yen, S., Yershov, N., Yokoyama, M., Zalewska, A., Zalipska, J., Zaremba, K., Ziembicki, M., Zimmerman, E.D., Zito, M., and Zmuda, J.
- Subjects
Physics::Instrumentation and Detectors ,High Energy Physics::Phenomenology ,High Energy Physics::Experiment - Abstract
The T2K experiment is a long baseline neutrino oscillation experiment. Its main goal is to measure the\ud last unknown lepton sector mixing angle y13 by observing ne appearance in a nm beam. It also aims to\ud make a precision measurement of the known oscillation parameters, Dm2\ud 23 and sin2\ud 2y23, via nm\ud disappearance studies. Other goals of the experiment include various neutrino cross-section measurements and sterile neutrino searches. The experiment uses an intense proton beam generated by the\ud J-PARC accelerator in Tokai, Japan, and is composed of a neutrino beamline, a near detector complex\ud (ND280), and a far detector (Super-Kamiokande) located 295 km away from J-PARC. This paper\ud provides a comprehensive review of the instrumentation aspect of the T2K experiment and a summary\ud of the vital information for each subsystem.
- Published
- 2011
26. FREE-STREAM TURBULENCE EFFECTS ON A SEPARATION BUBBLE
- Author
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KIYA, M., primary and SASAKI, K., additional
- Published
- 1984
- Full Text
- View/download PDF
27. DEVELOPMENT OF LARGE BORE-HIGH CURRENT Nb3Sn COIL
- Author
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Ando, T., primary, Takahashi, Y., additional, Nishi, M., additional, Tsuji, H., additional, Shimamoto, S., additional, Yasukochi, K., additional, Hamajima, T., additional, Miura, A., additional, Fujiwara, N., additional, Osaki, O., additional, Sasaki, K., additional, Murase, S., additional, and Fujioka, T., additional
- Published
- 1983
- Full Text
- View/download PDF
28. Numerical Simulation of Nonproportional Cyclic Plasticity
- Author
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Ishikawa, H., primary and Sasaki, K., additional
- Published
- 1989
- Full Text
- View/download PDF
29. LIST OF CONTRIBUTORS AND DISCUSSANTS
- Author
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Ahmed, C.E., primary, Albertson, B.D., additional, Andreone, T., additional, Anogianakis, G., additional, Asa, S., additional, Atlas, S.A., additional, Aurbach, G.D., additional, Baird, A., additional, Bardin, C.W., additional, Barnes, K.M., additional, Beale, E., additional, Beck, J.C., additional, Bennett, H.P.J., additional, Billard, R., additional, Blizzard, R.M., additional, Böhlen, P., additional, Borges, J.L.C., additional, Bradlow, H.L., additional, Brand, S.J., additional, Brandi, M.L., additional, Bremner, W.J., additional, Broadus, A.E., additional, Brook, C., additional, Burtis, W.J., additional, Callard, G., additional, Callard, I., additional, Campbell, G.T., additional, Campen, C., additional, Carey, R.M., additional, Caruso-Nicoletti, M., additional, Cassorla, F.G., additional, Catterall, J.F., additional, Chang, J.P., additional, Chen, T.T., additional, Clark, J.H., additional, Cohen, S., additional, Comite, F., additional, Cronin, M.J., additional, Cuello, C., additional, Cutler, G.B., additional, Delahunty, G., additional, Dobyns, B.M., additional, Draper, M.W., additional, Drucker, W.D., additional, Eckstein, B., additional, Esch, F., additional, Evans, W.S., additional, Everitt, B., additional, Feuillan, P., additional, Fitzpatrick, L.A., additional, Foster, C.M., additional, Foster, D.L., additional, Freeman, M.W., additional, Friesen, H.G., additional, Frohman, L., additional, Funkenstein, D., additional, Furlanetto, R., additional, Garcia, H.B., additional, Geller, J., additional, Gill, J.R., additional, Godsall, J.W., additional, Goldstein, M., additional, Goltzman, D., additional, Gorski, J., additional, Granner, D.K., additional, Greengard, P., additional, Greep, R., additional, Greer, M.A., additional, Grumbach, M.M., additional, Guillemin, R., additional, Hansen, J., additional, Hart, C., additional, Hemmings, H., additional, Hench, K.D., additional, Hershman, J.M., additional, Hickok, N.J., additional, Hinds, L.A., additional, Ho, K., additional, Hoffman, R.A., additional, Hökfelt, T., additional, Horton, T., additional, Horvath, E., additional, Hulting, A.-L., additional, Igarashi, T., additional, Insogna, K.L., additional, Jänne, O.A., additional, Johansson, O., additional, Kaplan, S.L., additional, Karch, F.J., additional, Kassis, J., additional, Katz, M.S., additional, Keefe, D.L., additional, Kelch, R.P., additional, Kelly, P.A., additional, Kelly, T.M., additional, Kenigsburg, D., additional, Klingensmith, G.J., additional, Knobil, E., additional, Kontula, K.K., additional, Koutsilieris, M., additional, Kovacs, K., additional, Kronenberg, H.M., additional, Kulin, H., additional, Laherty, R.F., additional, Lakoski, J.M., additional, Laue, L., additional, Lederis, K., additional, Lefevre, Y.A., additional, Leong, D.A., additional, LeRoith, D., additional, Lesniak, M.A., additional, Ling, N., additional, Long, L.M., additional, Loriaux, D.L., additional, Lundberg, J.M., additional, Maack, T., additional, MacDonald, G.J., additional, MacLeod, R.M., additional, McConnell, S.J., additional, Means, A., additional, Meister, B., additional, Melander, T., additional, Melanitou, E., additional, Meiner, M.H., additional, Meserve, L.A., additional, Mitchell, J., additional, Morgan, R.O., additional, Mormède, P., additional, Morris, D.J., additional, Murphy, L., additional, Nahorniak, C.S., additional, Nekola, M.V., additional, New, M.I., additional, Nicoll, C.S., additional, Nolin, J.M., additional, Odell, W.D., additional, Ojeda, S.R., additional, Okazaki, T., additional, Olster, D.H., additional, Omeljaniuk, R.J., additional, Osathanondh, R., additional, Ouimet, C., additional, Papkoff, H., additional, Pescovitz, O.H., additional, Peter, R.E., additional, Pomerantz, D.K., additional, Potts, J.T., additional, Rabbani, S.A., additional, Raj, M., additional, Rall, J.E., additional, Reichlin, S., additional, Rice, B.F., additional, Rittmaster, R., additional, Rivier, J., additional, Roberts, C.T., additional, Robinson, J., additional, Rogol, A.D., additional, Ross, J.L., additional, Roth, J., additional, Rouleau, M.F., additional, Ryan, K.D., additional, Ryan, R., additional, Saffran, M., additional, Sakai, D., additional, Samaan, N., additional, Sasaki, K., additional, Schalling, M., additional, Schriock, E.A., additional, Schwartz, N.B., additional, Scoggins, B.A., additional, Segre, G., additional, Sen, S., additional, Seppänen, P.J., additional, Shemer, J., additional, Sherman, M.R., additional, Shih, S.H., additional, Shiloach, J., additional, Shull, J., additional, Singh, P., additional, Skerda, M.C., additional, Smith, P., additional, Sokolowska, M., additional, Spitz, I.M., additional, Stack, G., additional, Stewart, A.F., additional, Stewart, D.R., additional, Tait, J.F., additional, Terasawa, E., additional, Thorner, M.O., additional, Tyndale-Biscoe, C.H., additional, Ueno, N., additional, Urbanski, H.F., additional, Uriarte, M., additional, Vale, W., additional, Vance, M.L., additional, VanderLaan, W., additional, Vecsei, P., additional, Veldhuis, J.D., additional, Walaas, I., additional, Walent, J., additional, Walters, M., additional, Watson, C.S., additional, Wehrenberg, W.B., additional, Welshons, W.V., additional, Werner, S., additional, Wilson, G.L., additional, Wiren, K.M., additional, Yellon, S.M., additional, Ying, S.-Y., additional, and Yoshinaga, K., additional
- Published
- 1986
- Full Text
- View/download PDF
30. GAIN MAXIMIZING DISSOLVED OXYGEN CONTROL IN THE ACTIVATED SLUDGE PROCESS
- Author
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Tanuma, R., primary, Sasaki, K., additional, and Matsunaga, I., additional
- Published
- 1985
- Full Text
- View/download PDF
31. Subsequent Loading of SUS304 After Cyclic Preloading
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Sasaki, K., primary and Ishikawa, H., additional
- Published
- 1989
- Full Text
- View/download PDF
32. Effects of total gas flow rate and sputtering power on the critical condition for target mode transition in Al?O2 reactive sputtering
- Author
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Chiba, Y, Abe, Y, Kawamura, M, Sasaki, K, Chiba, Y, Abe, Y, Kawamura, M, and Sasaki, K
- Abstract
Reactive sputtering is one of the most commonly used techniques for the fabrication of compound thin films, and the critical condition for target mode transition from metal mode to oxide mode is very important. We investigated the effects of total gas flow rate and sputtering power on the critical condition in Al-O2 reactive sputtering. It was found that the ratio of the number of sputtered Al atoms (NAl) to the number of supplied O atoms (NO) at the critical condition was almost constant, and the ratio of NAl to NO was close to the stoichiometric ratio of Al2O3 (2 to 3). It is thought that the introduced oxygen is gettered by Al atoms almost completely and the target remains in the metal mode below the critical condition. By increasing the amount of supplied O atoms above the stoichiometric ratio of Al2O3, the oxygen supply overcomes the gettering effect. Then, oxygen concentration in the plasma increases abruptly and the target mode changes from metal mode to oxide mode., application/pdf
- Published
- 2009
33. A constitutive model of cyclic viscoplasticity considering changes in subsequent viscoplastic deformation due to the evolution of dislocation structures
- Author
-
Mayama, T., 1000090215715, Sasaki, K., Ishikawa, H., Mayama, T., 1000090215715, Sasaki, K., and Ishikawa, H.
- Abstract
This paper presents a unified constitutive model for cyclic viscoplasticity and changes occurring in subsequent viscoplastic deformation due to the evolution of dislocation structures. The model considers the viscoplastic potential and a modified Ramberg–Osgood law. Stress is assumed to divide into three components: back stress (the center of the yield surface), flow stress (the radius of the yield surface), and viscous stress (overstress). The modification of the Ramberg–Osgood law is carried out employing memorized back stress. The applicability of the model to monotonic loading, pure creep, tension–compression cyclic loading, subsequent creep, and subsequent stress-relaxation were verified by comparing the predictions with experiments of Type 316L stainless steel at room temperature. The relationships between the internal variables in the model and the dislocation structures organized by cyclic deformations are also discussed.
- Published
- 2007
34. Influence of oxygen flow ratio on the oxidation of Ti target and the formation process of TiO_2 films by reactive sputtering
- Author
-
Takamura, K., Abe, Y., Sasaki, K., Takamura, K., Abe, Y., and Sasaki, K.
- Abstract
Ti and TiO_2 films were deposited by RF reactive sputtering using a mixed gas of Ar and O_2. TiO_2 films were found to be formed at oxygen flow ratios above 7%. At the critical O_2 flow ratio, the amount of supplied Ti atoms was found to agree with that of O_2 molecules. Above the critical O_2 flow ratio, the amount of supplied O_2 molecules exceeded the gettering effect of the sputtering Ti atoms and oxygen density in the plasma began to increase. As a result, the surface of the Ti target was oxidized and TiO_2 films were formed. The thickness of the oxide film formed on the Ti target increased with increasing oxygen flow ratio and a maximum thickness of 5-6 nm was obtained at oxygen flow ratios of 40-100%., application/pdf
- Published
- 2004
35. Search for heavy long-lived charged R-hadrons with the ATLAS detector in 3.2 fb−1 of proton–proton collision data at s=13 TeV
- Author
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- Subjects
Nuclear and High Energy Physics ,High Energy Physics::Phenomenology ,High Energy Physics::Experiment ,Nuclear Experiment ,lcsh:Physics ,lcsh:QC1-999 - Abstract
A search for heavy long-lived charged R-hadrons is reported using a data sample corresponding to 3.2 fb−1 of proton–proton collisions at s=13 TeV collected by the ATLAS experiment at the Large Hadron Collider at CERN. The search is based on observables related to large ionisation losses and slow propagation velocities, which are signatures of heavy charged particles travelling significantly slower than the speed of light. No significant deviations from the expected background are observed. Upper limits at 95% confidence level are provided on the production cross section of long-lived R-hadrons in the mass range from 600 GeV to 2000 GeV and gluino, bottom and top squark masses are excluded up to 1580 GeV, 805 GeV and 890 GeV, respectively.
- Published
- 2016
36. Measurement of the W + W − production cross section in pp collisions at a centre-of-mass energy of s=13 TeV with the ATLAS experiment
- Author
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Aaboud, M., Aad, G., Abbott, B., Abdallah, J., Abdinov, O., Abeloos, B., Aben, R., Abouzeid, O. S., Abraham, N. L., Abramowicz, H., Abreu, H., Abreu, R., Abulaiti, Y., Acharya, B. S., Adachi, S., Adamczyk, L., Adams, D. L., Adelman, J., Adomeit, S., Adye, T., Affolder, A. A., Agatonovic-Jovin, T., Aguilar-Saavedra, J. A., Ahlen, S. P., Ahmadov, F., Aielli, G., Akerstedt, H., Ã…kesson, T. P. A., Akimov, A. V., Alberghi, G. L., Albert, J., Albrand, S., Alconada Verzini, M. J., Aleksa, M., Aleksandrov, I. N., Alexa, C., Alexander, G., Alexopoulos, T., Alhroob, M., Ali, B., Aliev, M., Alimonti, G., Alison, J., Alkire, S. P., Allbrooke, B. M. M., Allen, B. W., Allport, P. P., Aloisio, A., Alonso, A., Alonso, F., Alpigiani, C., Alshehri, A. A., Alstaty, M., Alvarez Gonzalez, B., Ãlvarez Piqueras, D., Alviggi, M. G., Amadio, B. T., Amaral Coutinho, Y., Amelung, C., Amidei, D., Amor Dos Santos, S. P., Amorim, A., Amoroso, S., Amundsen, G., Anastopoulos, C., Ancu, L. S., Andari, N., Andeen, T., Anders, C. F., Anders, G., Anders, J. K., Anderson, K. J., Andreazza, A., Andrei, V., Angelidakis, S., Angelozzi, I., Angerami, A., Anghinolfi, F., Anisenkov, A. V., Anjos, N., Annovi, A., Antel, C., Antonelli, M., Antonov, A., Antrim, D. J., Anulli, F., Aoki, M., Aperio Bella, L., Arabidze, G., Arai, Y., Araque, J. P., Arce, A. T. H., Arduh, F. A., Arguin, J. -. F., Argyropoulos, S., Arik, M., Armbruster, A. J., Armitage, L. J., Arnaez, O., Arnold, H., Arratia, M., Arslan, O., Artamonov, A., Artoni, G., Artz, S., Asai, S., Asbah, N., Ashkenazi, A., Ã…sman, B., Asquith, L., Assamagan, K., Astalos, R., Atkinson, M., Atlay, N. B., Augsten, K., Avolio, G., Axen, B., Ayoub, M. K., Azuelos, G., Baak, M. A., Baas, A. E., Baca, M. J., Bachacou, H., Bachas, K., Backes, M., Backhaus, M., Bagiacchi, P., Bagnaia, P., Bai, Y., Baines, J. T., Bajic, M., Baker, O. K., Baldin, E. M., Balek, P., Balestri, T., Balli, F., Balunas, W. 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Savic, C. Sawyer, L. Sawyer, J. Saxon, C. Sbarra, A. Sbrizzi, T. Scanlon, D.A. Scannicchio, M. Scarcella, V. Scarfone, J. Schaarschmidt, P. Schacht, B.M. Schachtner, D. Schaefer, L. Schaefer, R. Schaefer, J. Schaeffer, S. Schaepe, S. Schaetzel, U. Schäfer, A.C. Schaffer, D. Schaile, R.D. Schamberger, V. Scharf, V.A. Schegelsky, D. Scheirich, M. Schernau, C. Schiavi, S. Schier, C. Schillo, M. Schioppa, S. Schlenker, K.R. Schmidt-Sommerfeld, K. Schmieden, C. Schmitt, S. Schmitt, S. Schmitz, B. Schneider, U. Schnoor, L. Schoeffel, A. Schoening, B.D. Schoenrock, E. Schopf, M. Schott, J.F.P. Schouwenberg, J. Schovancova, S. Schramm, M. Schreyer, N. Schuh, A. Schulte, M.J. Schultens, H.-C. Schultz-Coulon, H. Schulz, M. Schumacher, B.A. Schumm, Ph. Schune, A. Schwartzman, T.A. Schwarz, H. Schweiger, Ph. Schwemling, R. Schwienhorst, J. Schwindling, T. Schwindt, G. Sciolla, F. Scuri, F. Scutti, J. Searcy, P. Seema, S.C. Seidel, A. Seiden, F. Seifert, J.M. Seixas, G. Sekhniaidze, K. Sekhon, S.J. Sekula, D.M. Seliverstov, N. Semprini-Cesari, C. Serfon, L. Serin, L. Serkin, M. Sessa, R. Seuster, H. Severini, T. Sfiligoj, F. Sforza, A. Sfyrla, E. Shabalina, N.W. Shaikh, L.Y. Shan, R. Shang, J.T. Shank, M. Shapiro, P.B. Shatalov, K. Shaw, S.M. Shaw, A. Shcherbakova, C.Y. Shehu, P. Sherwood, L. Shi, S. Shimizu, C.O. Shimmin, M. Shimojima, S. Shirabe, M. Shiyakova, A. Shmeleva, D. Shoaleh Saadi, M.J. Shochet, S. Shojaii, D.R. Shope, S. Shrestha, E. Shulga, M.A. Shupe, P. Sicho, A.M. Sickles, P.E. Sidebo, E. Sideras Haddad, O. Sidiropoulou, D. Sidorov, A. Sidoti, F. Siegert, Dj. Sijacki, J. Silva, S.B. Silverstein, V. Simak, Lj. Simic, S. Simion, E. Simioni, B. Simmons, D. Simon, M. Simon, P. Sinervo, N.B. Sinev, M. Sioli, G. Siragusa, S.Yu. Sivoklokov, J. Sjölin, M.B. Skinner, H.P. Skottowe, P. Skubic, M. Slater, T. Slavicek, M. Slawinska, K. Sliwa, R. Slovak, V. Smakhtin, B.H. Smart, L. Smestad, J. Smiesko, S.Yu. Smirnov, Y. Smirnov, L.N. Smirnova, O. Smirnova, J.W. Smith, M.N.K. Smith, R.W. Smith, M. Smizanska, K. Smolek, A.A. Snesarev, I.M. Snyder, S. Snyder, R. Sobie, F. Socher, A. Soffer, D.A. Soh, G. Sokhrannyi, C.A. Solans Sanchez, M. Solar, E.Yu. Soldatov, U. Soldevila, A.A. Solodkov, A. Soloshenko, O.V. Solovyanov, V. Solovyev, P. Sommer, H. Son, H.Y. Song, A. Sood, A. Sopczak, V. Sopko, V. Sorin, D. Sosa, C.L. Sotiropoulou, R. Soualah, A.M. Soukharev, D. South, B.C. Sowden, S. Spagnolo, M. Spalla, M. Spangenberg, F. Spanò, D. Sperlich, F. Spettel, R. Spighi, G. Spigo, L.A. Spiller, M. Spousta, R.D. St. Denis, A. Stabile, R. Stamen, S. Stamm, E. Stanecka, R.W. Stanek, C. Stanescu, M. Stanescu-Bellu, M.M. Stanitzki, S. Stapnes, E.A. Starchenko, G.H. Stark, J. Stark, P. Staroba, P. Starovoitov, S. Stärz, R. Staszewski, P. Steinberg, B. Stelzer, H.J. Stelzer, O. Stelzer-Chilton, H. Stenzel, G.A. Stewart, J.A. Stillings, M.C. Stockton, M. Stoebe, G. Stoicea, P. Stolte, S. Stonjek, A.R. Stradling, A. Straessner, M.E. Stramaglia, J. Strandberg, S. Strandberg, A. Strandlie, M. Strauss, P. Strizenec, R. Ströhmer, D.M. Strom, R. Stroynowski, A. Strubig, S.A. Stucci, B. Stugu, N.A. Styles, D. Su, J. Su, S. Suchek, Y. Sugaya, M. Suk, V.V. Sulin, S. Sultansoy, T. Sumida, S. Sun, X. Sun, J.E. Sundermann, K. Suruliz, C.J.E. Suster, M.R. Sutton, S. Suzuki, M. Svatos, M. Swiatlowski, S.P. Swift, I. Sykora, T. Sykora, D. Ta, C. Taccini, K. Tackmann, J. Taenzer, A. Taffard, R. Tafirout, N. Taiblum, H. Takai, R. Takashima, T. Takeshita, Y. Takubo, M. Talby, A.A. Talyshev, K.G. Tan, J. Tanaka, M. Tanaka, R. Tanaka, S. Tanaka, R. Tanioka, B.B. Tannenwald, S. Tapia Araya, S. Tapprogge, S. Tarem, G.F. Tartarelli, P. Tas, M. Tasevsky, T. Tashiro, E. Tassi, A. Tavares Delgado, Y. Tayalati, A.C. Taylor, G.N. Taylor, P.T.E. Taylor, W. Taylor, F.A. Teischinger, P. Teixeira-Dias, K.K. Temming, D. Temple, H. Ten Kate, P.K. Teng, J.J. Teoh, F. Tepel, S. Terada, K. Terashi, J. Terron, S. Terzo, M. Testa, R.J. Teuscher, T. Theveneaux-Pelzer, J.P. Thomas, J. Thomas-Wilsker, P.D. Thompson, A.S. Thompson, L.A. Thomsen, E. Thomson, M.J. Tibbetts, R.E. Ticse Torres, V.O. Tikhomirov, Yu.A. Tikhonov, S. Timoshenko, P. Tipton, S. Tisserant, K. Todome, T. Todorov, S. Todorova-Nova, J. Tojo, S. Tokár, K. Tokushuku, E. Tolley, L. Tomlinson, M. Tomoto, L. Tompkins, K. Toms, B. Tong, P. Tornambe, E. Torrence, H. Torres, E. Torró Pastor, J. Toth, F. Touchard, D.R. Tovey, T. Trefzger, A. Tricoli, I.M. Trigger, S. Trincaz-Duvoid, M.F. Tripiana, W. Trischuk, B. Trocmé, A. Trofymov, C. Troncon, M. Trottier-McDonald, M. Trovatelli, L. Truong, M. Trzebinski, A. Trzupek, J.C-L. Tseng, P.V. Tsiareshka, G. Tsipolitis, N. Tsirintanis, S. Tsiskaridze, V. Tsiskaridze, E.G. Tskhadadze, K.M. Tsui, I.I. Tsukerman, V. Tsulaia, S. Tsuno, D. Tsybychev, Y. Tu, A. Tudorache, V. Tudorache, T.T. Tulbure, A.N. Tuna, S.A. Tupputi, S. Turchikhin, D. Turgeman, I. Turk Cakir, R. Turra, P.M. Tuts, G. Ucchielli, I. Ueda, M. Ughetto, F. Ukegawa, G. Unal, A. Undrus, G. Unel, F.C. Ungaro, Y. Unno, C. Unverdorben, J. Urban, P. Urquijo, P. Urrejola, G. Usai, J. Usui, L. Vacavant, V. Vacek, B. Vachon, C. Valderanis, E. Valdes Santurio, N. Valencic, S. Valentinetti, A. Valero, L. Valery, S. Valkar, J.A. Valls Ferrer, W. Van Den Wollenberg, P.C. Van Der Deijl, H. van der Graaf, N. van Eldik, P. van Gemmeren, J. Van Nieuwkoop, I. van Vulpen, M.C. van Woerden, M. Vanadia, W. Vandelli, R. Vanguri, A. Vaniachine, P. Vankov, G. Vardanyan, R. Vari, E.W. Varnes, T. Varol, D. Varouchas, A. Vartapetian, K.E. Varvell, J.G. Vasquez, G.A. Vasquez, F. Vazeille, T. Vazquez Schroeder, J. Veatch, V. Veeraraghavan, L.M. Veloce, F. Veloso, S. Veneziano, A. Ventura, M. Venturi, N. Venturi, A. Venturini, V. Vercesi, M. Verducci, W. Verkerke, J.C. Vermeulen, A. Vest, M.C. Vetterli, O. Viazlo, I. Vichou, T. Vickey, O.E. Vickey Boeriu, G.H.A. Viehhauser, S. Viel, L. Vigani, M. Villa, M. Villaplana Perez, E. Vilucchi, M.G. Vincter, V.B. Vinogradov, C. Vittori, I. Vivarelli, S. Vlachos, M. Vlasak, M. Vogel, P. Vokac, G. Volpi, M. Volpi, H. von der Schmitt, E. von Toerne, V. Vorobel, K. Vorobev, M. Vos, R. Voss, J.H. Vossebeld, N. Vranjes, M. Vranjes Milosavljevic, V. Vrba, M. Vreeswijk, R. Vuillermet, I. Vukotic, P. Wagner, W. Wagner, H. Wahlberg, S. Wahrmund, J. Wakabayashi, J. Walder, R. Walker, W. Walkowiak, V. Wallangen, C. Wang, C. Wang, F. Wang, H. Wang, H. Wang, J. Wang, J. Wang, K. Wang, R. Wang, S.M. Wang, T. Wang, W. Wang, C. Wanotayaroj, A. Warburton, C.P. Ward, D.R. Wardrope, A. Washbrook, P.M. Watkins, A.T. Watson, M.F. Watson, G. Watts, S. Watts, B.M. Waugh, S. Webb, M.S. Weber, S.W. Weber, S.A. Weber, J.S. Webster, A.R. Weidberg, B. Weinert, J. Weingarten, C. Weiser, H. Weits, P.S. Wells, T. Wenaus, T. Wengler, S. Wenig, N. Wermes, M.D. Werner, P. Werner, M. Wessels, J. Wetter, K. Whalen, N.L. Whallon, A.M. Wharton, A. White, M.J. White, R. White, D. Whiteson, F.J. Wickens, W. Wiedenmann, M. Wielers, C. Wiglesworth, L.A.M. Wiik-Fuchs, A. Wildauer, F. Wilk, H.G. Wilkens, H.H. Williams, S. Williams, C. Willis, S. Willocq, J.A. Wilson, I. Wingerter-Seez, F. Winklmeier, O.J. Winston, B.T. Winter, M. Wittgen, T.M.H. Wolf, R. Wolff, M.W. Wolter, H. Wolters, S.D. Worm, B.K. Wosiek, J. Wotschack, M.J. Woudstra, K.W. Wozniak, M. Wu, M. Wu, S.L. Wu, X. Wu, Y. Wu, T.R. Wyatt, B.M. Wynne, S. Xella, Z. Xi, D. Xu, L. Xu, B. Yabsley, S. Yacoob, D. Yamaguchi, Y. Yamaguchi, A. Yamamoto, S. Yamamoto, T. Yamanaka, K. Yamauchi, Y. Yamazaki, Z. Yan, H. Yang, H. Yang, Y. Yang, Z. Yang, W-M. Yao, Y.C. Yap, Y. Yasu, E. Yatsenko, K.H. Yau Wong, J. Ye, S. Ye, I. Yeletskikh, E. Yildirim, K. Yorita, R. Yoshida, K. Yoshihara, C. Young, C.J.S. Young, S. Youssef, D.R. Yu, J. Yu, J.M. Yu, J. Yu, L. Yuan, S.P.Y. Yuen, I. Yusuff, B. Zabinski, G. Zacharis, R. Zaidan, A.M. Zaitsev, N. Zakharchuk, J. Zalieckas, A. Zaman, S. Zambito, L. Zanello, D. Zanzi, C. Zeitnitz, M. Zeman, A. Zemla, J.C. Zeng, Q. Zeng, O. Zenin, T. Ženiš, D. Zerwas, D. Zhang, F. Zhang, G. Zhang, H. Zhang, J. Zhang, L. Zhang, L. Zhang, M. Zhang, R. Zhang, R. Zhang, X. Zhang, Z. Zhang, X. Zhao, Y. Zhao, Z. Zhao, A. Zhemchugov, J. Zhong, B. Zhou, C. Zhou, L. Zhou, L. Zhou, M. Zhou, N. Zhou, C.G. Zhu, H. Zhu, J. Zhu, Y. Zhu, X. Zhuang, K. Zhukov, A. Zibell, D. Zieminska, N.I. Zimine, C. Zimmermann, S. Zimmermann, Z. Zinonos, M. Zinser, M. Ziolkowski, L. Živković, G. Zobernig, A. Zoccoli, M. zur Nedden, L. Zwalinski
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Nuclear and High Energy Physics ,Physics::Instrumentation and Detectors ,High Energy Physics::Phenomenology ,Physics::Accelerator Physics ,High Energy Physics::Experiment ,lcsh:Physics ,lcsh:QC1-999 - Abstract
The production of opposite-charge W-boson pairs in protonâproton collisions at s=13 TeV is measured using data corresponding to 3.16 fbâ1of integrated luminosity collected by the ATLAS detector at the CERN Large Hadron Collider in 2015. Candidate W-boson pairs are selected by identifying their leptonic decays into an electron, a muon and neutrinos. Events with reconstructed jets are not included in the candidate event sample. The cross-section measurement is performed in a fiducial phase space close to the experimental acceptance and is compared to theoretical predictions. Agreement is found between the measurement and the most accurate calculations available.
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- 2017
37. The role of liver-directed surgery in patients with hepatic metastasis from primary breast cancer: a multi-institutional analysis
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Lauren M. Postlewait, Nadia Russolillo, Shishir K. Maithel, Eduardo Barroso, Alex D. Michaels, Yuhree Kim, Francesca Ratti, Georgios A. Margonis, N. Berger, Luca Aldrighetti, Timothy M. Pawlik, Alessandro Ferrero, Todd W. Bauer, Kazunari Sasaki, Thuy B. Tran, Stefan Buettner, Hugo Marques, George A. Poultsides, T. Clark Gamblin, Margonis, Ga, Buettner, S, Sasaki, K, Kim, Y, Ratti, F, Russolillo, N, Ferrero, A, Berger, N, Gamblin, Tc, Poultsides, G, Tran, T, Postlewait, Lm, Maithel, S, Michaels, Ad, Bauer, Tw, Marques, H, Barroso, E, Aldrighetti, L, and Pawlik, Tm
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Oncology ,medicine.medical_specialty ,Time Factors ,Databases, Factual ,medicine.medical_treatment ,Breast Neoplasms ,Kaplan-Meier Estimate ,Metastasis ,03 medical and health sciences ,0302 clinical medicine ,Breast cancer ,Risk Factors ,Internal medicine ,medicine ,Hepatectomy ,Humans ,In patient ,030212 general & internal medicine ,skin and connective tissue diseases ,Selection Bias ,Aged ,Proportional Hazards Models ,Hepatology ,Portugal ,business.industry ,Proportional hazards model ,Liver Neoplasms ,Gastroenterology ,Metastasectomy ,Margins of Excision ,Middle Aged ,medicine.disease ,Hepatic metastasis ,United States ,Surgery ,Tumor Burden ,Editorial ,Treatment Outcome ,Italy ,030220 oncology & carcinogenesis ,Multivariate Analysis ,Female ,Original Article ,business ,Primary breast cancer ,CHLC CHBPT - Abstract
BACKGROUND: Data on surgical management of breast liver metastasis are limited. We sought to determine the safety and long-term outcome of patients undergoing hepatic resection of breast cancer liver metastases (BCLM). METHODS: Using a multi-institutional, international database, 131 patients who underwent surgery for BCLM between 1980 and 2014 were identified. Clinicopathologic and outcome data were collected and analyzed. RESULTS: Median tumor size of the primary breast cancer was 2.5 cm (IQR: 2.0-3.2); 58 (59.8%) patients had primary tumor nodal metastasis. The median time from diagnosis of breast cancer to metastasectomy was 34 months (IQR: 16.8-61.3). The mean size of the largest liver lesion was 3.0 cm (2.0-5.0); half of patients (52.0%) had a solitary metastasis. An R0 resection was achieved in most cases (90.8%). Postoperative morbidity and mortality were 22.8% and 0%, respectively. Median and 3-year overall-survival was 53.4 months and 75.2%, respectively. On multivariable analysis, positive surgical margin (HR 3.57, 95% CI 1.40-9.16; p = 0.008) and diameter of the BCLM (HR 1.03, 95% CI 1.01-1.06; p = 0.002) remained associated with worse OS. DISCUSSION: In selected patients, resection of breast cancer liver metastases can be done safely and a subset of patients may derive a relatively long survival, especially from a margin negative resection. info:eu-repo/semantics/publishedVersion
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- 2016
38. Effect of Facet Joint Resection on Postoperative Radiographic and Clinical Outcomes After Microendoscopic Laminectomy for Single-Level Lumbar Spinal Stenosis.
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Doi T, Hirai S, Horii C, Sasaki K, Yamato Y, Nakajima K, Okazaki K, Inanami H, Iwai H, and Oshima Y
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Objective: Facet joint destruction causes postoperative spinal instability, resulting in poor clinical outcomes after lumbar decompression surgery. However, the effect of facet joint destruction on radiographic and clinical outcomes after microendoscopic laminectomy (MEL) is unknown. Therefore, the current study aimed to examine the effect of facet joint resection on radiographic and clinical outcomes after single-level MEL surgery., Methods: This study included 116 patients with lumbar spinal canal stenosis (LSCS) who underwent single-level (L4/5) MEL surgery. Eligible patients were divided into the following groups: group P (facet joint preservation rate = 100%) (n = 70); group PR (50% ≤ the facet joint preservation rate <100%) (n = 27); and group R (the facet joint preservation rate <50%) (n = 19). The demographic characteristics of the patients, surgical data, preoperative and 1-year postoperative radiographic measurements, and clinical outcomes were compared among the 3 groups. Moreover, preoperative and postoperative radiographic and clinical outcomes were compared after adjusting the demographic characteristics of the patients and surgical data by the inverse probability weighting method with propensity scores., Results: The 3 unweighted groups did not significantly differ in terms of demographic characteristics, surgical data, and preoperative and postoperative radiographic and clinical outcomes. Even after adjusting for the demographic characteristics and surgical data, the preoperative and postoperative radiographic and clinical outcomes were comparable among the 3 weighted groups., Conclusions: The extent of facet joint resection might have a minimal impact on radiographic and clinical outcomes at 1 year after single-level MEL surgery., (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)
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- 2024
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39. Brain drug delivery from the nasal olfactory region is enhanced using lauroylcholine chloride: An estimation using in vivo PET imaging.
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Fukakusa S, Suzuki C, Sasaki K, Sonoda Y, Hatano Y, Haruta S, and Magata Y
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Introduction: Intranasal (IN) administration, often referred to as nose-to-brain (N2B) drug delivery, is an attractive approach for delivering drugs to the central nervous system. However, the efficacy of this method is limited because of the small size of the nasal olfactory region, which limits the drug dosage. Using permeation enhancers could improve drug delivery from this region to the brain, though their effects are not fully understood. We therefore investigated the effects of co-administration of permeation enhancers on N2B drug delivery of a model drug domperidone, a peripherally acting dopamine D2 receptor (D2R) blocker., Methods: We conducted in vitro permeability assays to evaluate the effects of sodium lauryl sulfate (SLS), a classical permeation enhancer, and lauroylcholine chloride (LCC) on domperidone permeation in human nasal mucosa-derived cells. We also used the D2R ligand [
11 C]raclopride to assess the in vivo effects of LCC on domperidone delivery in the rat brain using a positron emission tomography (PET) competition paradigm. In comparative PET experiments, we tested the effects of intravenously administered domperidone without LCC co-administration., Results: LCC effectively improved nasal mucosal permeation of domperidone in vitro compared to SLS. In rat IN administration experiments, striatal [11 C]raclopride uptake was significantly decreased by the addition of LCC to domperidone. On the other hand, intravenously administered domperidone with or without intranasally administered LCC did not decrease [11 C]raclopride brain uptake, suggesting a lesser influence of peripheral domperidone on [11 C]raclopride brain uptake. PET studies showed that striatal D2R occupancy of domperidone was increased 2.4-fold by co-administration of LCC., Conclusion: LCC effectively enhances the domperidone delivery from the rat olfactory region to the brain, probably not via a circulating blood. The combination of permeation enhancers and olfactory region-selective drug administration could be effective for N2B drug delivery., Competing Interests: Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Suzuki C and Magata Y have no conflicts of interest to disclose. Fukakusa S, Sasaki K, Sonoda Y, Hatano Y, and Haruta S are full-time employees of SNBL., (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)- Published
- 2024
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40. Incidence and Clinical Presentation of Severe Neurotoxicity from Nelarabine in Patients with T-Cell Acute Lymphoblastic Leukemia.
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Braish JS, Kugler E, Jabbour E, Woodman K, Ravandi F, Nicholas S, Jain N, Kantarjian H, and Sasaki K
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- Humans, Male, Female, Adult, Retrospective Studies, Incidence, Middle Aged, Antineoplastic Agents adverse effects, Antineoplastic Agents therapeutic use, Young Adult, Aged, Arabinonucleosides adverse effects, Arabinonucleosides therapeutic use, Neurotoxicity Syndromes etiology, Neurotoxicity Syndromes diagnosis, Precursor T-Cell Lymphoblastic Leukemia-Lymphoma drug therapy, Precursor T-Cell Lymphoblastic Leukemia-Lymphoma complications
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Background: Nelarabine is a purine analog with demonstrated efficacy in the treatment of T-cell Lymphoblastic Leukemia and Lymphoma (T-ALL/LBL). Despite its efficacy and excellent blood-brain barrier penetration, it has a significant side effect profile which is namely concerning for neurotoxicity. Reported neurotoxicity has varied from mild peripheral neuropathy to debilitating grade 4 neurologic complications including Guillain-Barre like syndrome and myelopathy., Patients and Methods: We conducted a single centered, retrospective case series to study patients who developed severe neurotoxicity after receiving nelarabine as part of T-ALL treatment. One hundred thirty-five patients were identified. Thirteen patients were reviewed for severe neurotoxicity (defined as ≥grade 3), and of those five patients were deemed to have neurotoxicity secondary to nelarabine exposure., Results: Five patients (4%) developed severe neurotoxicity as manifested by Guillain-Barre like syndrome or myelopathy within a timeframe of eight to fifty-eight days from last nelarabine dose. Upon diagnosis, patients received formal neurologic evaluation by our neuro-oncology specialists including imaging, cerebrospinal fluid testing, and electromyography. Patients were treated with IVIG, and steroids upon diagnosis, but the majority of neuro-deficits were irreversible., Conclusion: Our study shows that nelarabine is generally well-tolerated, and the incidence of severe neurotoxicity is rare. Given the potential risk of severe neurotoxicity, we propose capped dose of nelarabine 1000 mg/day, neurological assessment before subsequent dosing, and avoidance of simultaneous IT therapy during nelarabine administration., (Copyright © 2024 Elsevier Inc. All rights reserved.)
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- 2024
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41. Does surgical site infection affect patient-reported outcomes after spinal surgery? A multicenter cohort study.
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Nakamoto H, Nakajima K, Miyahara J, Kato S, Doi T, Taniguchi Y, Matsubayashi Y, Nishizawa M, Kawamura N, Kumanomido Y, Higashikawa A, Sasaki K, Takeshita Y, Fukushima M, Iizuka M, Ono T, Yu J, Hara N, Okamoto N, Azuma S, Inanami H, Sakamoto R, Tanaka S, and Oshima Y
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- Humans, Male, Female, Middle Aged, Aged, Risk Factors, Cohort Studies, Adult, Elective Surgical Procedures adverse effects, Incidence, Spine surgery, Surgical Wound Infection epidemiology, Surgical Wound Infection etiology, Patient Reported Outcome Measures
- Abstract
Background: Surgical site infections are common in spinal surgeries. It is uncertain whether outcomes in spine surgery patients with vs. without surgical site infection are equivalent. Therefore, we assessed the effects of surgical site infection on postoperative patient-reported outcomes., Methods: We enrolled patients who underwent elective spine surgery at 12 hospitals between April 2017 and February 2020. We collected data regarding the patients' backgrounds, operative factors, and incidence of surgical site infection. Data for patient-reported outcomes, namely numerical rating scale, Neck Disability Index/Oswestry Disability Index, EuroQol Five-Dimensional questionnaire, and 12-Item Short-Form Health Survey scores, were obtained preoperatively and 1 year postoperatively. We divided the patients into with and without surgical site infection groups. Multivariate logistic regression analyses were performed to identify the risk factors for surgical site infection. Using propensity score matching, we obtained matched surgical site infection-negative and -positive groups. Student's t-test was used for comparisons of continuous variables, and Pearson's chi-square test was used to compare categorical variables between the two matched groups and two unmatched groups., Results: We enrolled 8861 patients in this study; 74 (0.8 %) developed surgical site infections. Cervical spine surgery and American Society of Anesthesiologists physical status classification ≥3 were identified as risk factors; microendoscopy was identified as a protective factor. Using propensity score matching, we compared surgical site infection-positive and -negative groups (74 in each group). No significant difference was found in postoperative pain or dysesthesia of the lower back, buttock, leg, and plantar area between the groups. When comparing preoperative with postoperative pain and dysesthesia, statistically significant improvement was observed for both variables in both groups (p < 0.01 for all variables). No significant differences were observed in postoperative outcomes between the matched surgical site infection-positive and -negative groups., Conclusions: Patients with surgical site infections had comparable postoperative outcomes to those without surgical site infections., Competing Interests: Declaration of competing interest None., (Copyright © 2023 The Japanese Orthopaedic Association. Published by Elsevier B.V. All rights reserved.)
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- 2024
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42. Feasibility of a problem-solving exercise program based on short physical performance battery for older patients with chronic respiratory diseases: A multicenter, pilot clinical trial.
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Hanada M, Nonoyama T, Ikeuchi T, Sasaki K, Suyama K, Nakashita M, Shiroishi R, Segawa R, Tanaka K, Aoki H, Kitagawa C, Hori Y, Hashimoto S, Matsuzaki T, Sato S, Arizono S, Tanaka T, and Kozu R
- Abstract
Background: This study aimed to assess the feasibility and safety of a problem-solving exercise program based on the items in the short physical performance battery (SPPB) for older patients with chronic respiratory diseases (CRDs) to inform future randomized controlled trials., Methods: This was a multicenter, prospective, non-randomized feasibility study. Participants with CRD received an enhancement program based on the SPPB decline items (balance, walk, and/or chair stand) for 4 weeks. The feasibility, safety, and efficacy of the problem-solving exercise program in improving the SPPB score, physical function, and step count (measured using a pedometer) were assessed., Results: Overall, 36 patients were enrolled in this study, and adherence to the exercise program was high (100%). No exercise program-related adverse events were observed. The implementation of the exercise program ranged from 70 to 100%. The mean daily step count increased from 2152 ± 1498 steps during the first week to 2899 ± 1865 steps in the last week (p<0.01). Additionally, the SPPB total score increased from 8.9 ± 1.8 points to 10.7 ± 1.3 points at the end of the program (p<0.001)., Conclusions: The problem-solving exercise program based on SPPB is feasible and safe for older patients with CRDs. However, the effectiveness of this exercise program should be validated in large-scale, randomized-controlled trials in the future., Trial Registration: University Hospital Medical Information Network Center (UMIN-CTR) UMIN: approval number: UMIN000048761., Competing Interests: Declaration of competing interest The authors have no conflicts of interest., (Copyright © 2024. Published by Elsevier B.V.)
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- 2024
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43. Letter to the editor: Liver machine perfusion technology in liver transplantation.
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Akabane M and Sasaki K
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- Humans, Liver surgery, Liver blood supply, Liver Transplantation, Perfusion methods, Organ Preservation methods
- Abstract
Competing Interests: Declaration of competing interest The authors of this manuscript have no conflicts of interest to disclose as described by the American Journal of Transplantation.
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- 2024
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44. Identification of exhaled volatile organic compounds that characterize asthma phenotypes: A J-VOCSA study.
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Suzukawa M, Ohta K, Sugimoto M, Ohshima N, Kobayashi N, Tashimo H, Tanimoto Y, Itano J, Kimura G, Takata S, Nakano T, Yamashita T, Ikegame S, Hyodo K, Abe M, Chibana K, Kamide Y, Sasaki K, and Hashimoto H
- Subjects
- Humans, Male, Female, Middle Aged, Cross-Sectional Studies, Adult, Biomarkers, Gas Chromatography-Mass Spectrometry, Aged, Japan, Asthma diagnosis, Asthma metabolism, Volatile Organic Compounds analysis, Phenotype, Breath Tests methods, Exhalation
- Abstract
Background: Asthma is characterized by phenotypes of different clinical, demographic, and pathological characteristics. Identifying the profile of exhaled volatile organic compounds (VOCs) in asthma phenotypes may facilitate establishing biomarkers and understanding asthma background pathogenesis. This study aimed to identify exhaled VOCs that characterize severe asthma phenotypes among patients with asthma., Methods: This was a multicenter cross-sectional study of patients with severe asthma in Japan. Clinical data were obtained from medical records, and questionnaires were collected. Exhaled breath was sampled and subjected to thermal desorption gas chromatography-mass spectrometry (GC/MS)., Results: Using the decision tree established in the previous nationwide asthma cohort study, 245 patients with asthma were divided into five phenotypes and subjected to exhaled VOC analysis with 50 healthy controls (HCs). GC/MS detected 243 VOCs in exhaled breath samples, and 142 frequently detected VOCs (50% of all samples) were used for statistical analyses. Cluster analysis assigning the groups with similar VOC profile patterns showed the highest similarities between phenotypes 3 and 4 (early-onset asthma phenotypes), followed by the similarities between phenotypes 1 and 2 (late-onset asthma phenotypes). Comparisons between phenotypes 1-5 and HC revealed 19 VOCs, in which only methanesulfonic anhydride showed p < 0.05 adjusted by false discovery rate (FDR). Comparison of these phenotypes yielded several VOCs showing different trends (p < 0.05); however, no VOCs showed p < 0.05 adjusted by FDR., Conclusions: Exhaled VOC profiles may be useful for distinguishing asthma and asthma phenotypes; however, these findings need to be validated, and their pathological roles should be clarified., (Copyright © 2024 Japanese Society of Allergology. Published by Elsevier B.V. All rights reserved.)
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- 2024
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45. Efficacy of Chemotherapy-Free Regimens in the Treatment of Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia: A Systematic Review and Meta-Analysis.
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Ali MA, Aiman W, Kantarjian H, Jabbour E, Ravandi F, Jain N, Short NJ, and Sasaki K
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- Humans, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Antineoplastic Combined Chemotherapy Protocols pharmacology, Protein Kinase Inhibitors therapeutic use, Protein Kinase Inhibitors pharmacology, Treatment Outcome, Philadelphia Chromosome, Precursor Cell Lymphoblastic Leukemia-Lymphoma drug therapy, Precursor Cell Lymphoblastic Leukemia-Lymphoma genetics
- Abstract
Introduction: The historical standard of care for Ph+ ALL is chemotherapy plus a tyrosine kinase inhibitor (TKI). Recently chemotherapy-free regimens have shown promising efficacy. We performed a meta-analysis to compare the efficacy of chemotherapy-free regimens for Ph+ ALL., Methods: We searched PubMed and Embase for chemotherapy-free regimens for Ph+ ALL published between January 2000 and October 2023. Of the 5,348 articles screened, 9 nonrandomized clinical trials enrolling 413 patients were included. Two trials (N = 117) included treatment with 3 agents (blinatumomab, TKI, and steroid) and 7 trials (N = 248) included treatment with 2 agents (TKI and steroids). R software was used to conduct the meta-analysis (PROSPERO registration no. CRD42023482439)., Results: The pooled complete molecular response (CMR) rate of patients receiving a TKI, blinatumomab, and steroids was 81% (95%CI, 69%-89%). TKIs plus blinatumomab were nearly 6 times as likely to have CMR (odds ratio [OR], 5.98; 95%CI, 2.99-11.96) and more than 5 times as likely to be alive at 1-year (OR, 5.1; 95%CI, 1.74-14.9) as compared to TKIs alone. Patients receiving ponatinib were about twice as likely as those receiving dasatinib to achieve CMR (OR, 2.51; 95%CI, 0.72-8.72)., Conclusion: Adding blinatumomab to TKIs and steroids significantly improved Ph+ ALL patients' response and survival rates. Regimens with ponatinib elicited higher molecular response rates than those with other TKIs. The high response and survival rates achieved with blinatumomab plus TKIs and steroids suggest that further studies are required to assess the need for intensive treatments such as chemotherapy or stem cell transplant in these patients., Competing Interests: Disclosures H.K.: research funding from AbbVie, Amgen, Ascentage, BMS, Daiichi-Sankyo, Immunogen, Jazz, Novartis; and honoraria/advisory board/consultancy from AbbVie, Amgen, Amphista, Ascentage, Astellas, Biologix, Curis, Ipsen Biopharmaceuticals, KAHR Medical, Labcorp, Novartis, Pfizer, Shenzhen Target Rx, Stemline, Takeda and Taiho Pharmaceutical Canada. E.J. received research grants from Abbvie, Adaptive Biotechnologies, Amgen, Pfizer, and Takeda; and consultancy fees from Abbvie, Adaptive Biotechnologies, Amgen, BMS, Genentech, Incyte, Novartis, Pfizer, and Takeda. F.R.: research funding from Amgen, Astex, Pharmaceuticals/Taiho Oncology, BMS/Celgene, Syos, AbbVie, Prelude, Xencor, Astellas Pharma, and Biomea Fusion as well as honoraria from Amgen, BMS/Celgene, Syos, AbbVie, and Astellas Pharma; has been a board of directors or advisory committee member for Astex Pharmaceuticals/Taiho Oncology; and has been a consultant for BMS/Celgene, Syos, Novartis, AbbVie, AstraZeneca, and Astellas Pharma. N.J.: served as a consultant/advisory role with Pharmacyclics, Novartis, ADC Therapeutics, Pfizer, Servier, Novimmune, and Adaptive Biotechnologies. He has received institutional research funding from Pharmacyclics, Genentech, Abbvie, Pfizer, Incyte, BMS, Infinity, ADC Therapeutics, Seattle Genetics, Celgene, and Servier. N.J.S.: has been a consultant for Takeda Oncology, AstraZeneca, Amgen, Novartis, and Pfizer; received research funding from Takeda Oncology, Astellas, and Stemline Therapeutics; and received honoraria from Amgen K.S.: received research funding from Novartis, honoraria from Otsuka, and consultation fees from Daiichi-Sankyo, Novartis, and Pfizer. M.A.A. and W.A. declare no conflict of interest., (Copyright © 2024 Elsevier Inc. All rights reserved.)
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- 2024
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46. Incidence and risk factors associated with the development of hypothyroidism after postoperative chemoradiotherapy for head and neck cancer patients with high-risk features: Supplementary analysis of JCOG1008.
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Shimizu H, Kodaira T, Kiyota N, Hayashi R, Nishino H, Asada Y, Mitani H, Hirayama Y, Onozawa Y, Nishio N, Hanai N, Ohkoshi A, Hara H, Monden N, Nagaoka M, Minami S, Fujii T, Tanaka K, Homma A, Yoshimoto S, Oridate N, Omori K, Ueda T, Okami K, Uemura H, Shiga K, Nakahira M, Asakage T, Saito Y, Sasaki K, Kitabayashi R, Ishikura S, Nishimura Y, and Tahara M
- Subjects
- Humans, Male, Female, Middle Aged, Risk Factors, Incidence, Aged, Chemoradiotherapy adverse effects, Adult, Hypothyroidism etiology, Hypothyroidism epidemiology, Head and Neck Neoplasms radiotherapy, Head and Neck Neoplasms therapy
- Abstract
Background and Purpose: Hypothyroidism is a recognized late adverse event following radiotherapy for head and neck cancer (HNC). In the JCOG1008 trial, we treated patients with high-risk HNC with postoperative chemoradiotherapy. We aimed to elucidate factors associated with hypothyroidism by analyzing the JCOG1008 data., Materials and Methods: In 2012-2018, 261 patients from 28 institutions were enrolled in JCOG1008. Thyroid function tests were conducted to assess hypothyroidism, including free thyroxine (FT4) and thyroid-stimulating hormone assays. Hypothyroidism was defined as Grade 2 or higher in CTCAE v4.0. Various clinical and dosimetric parameters were analyzed. In radiotherapy, there were no dose constraints for the thyroid. Multivariable analysis was conducted on these variables to identify predictive factors for hypothyroidism., Results: The analysis included 162 patients (57 with 3D-CRT and 105 with IMRT), with a median follow-up of 4.7 years (0.3-9.3 years). Among these, 27 (16.7 %) developed hypothyroidism within 2 years after radiotherapy. In a multivariable analysis, the weekly cisplatin [OR=7.700 (CI: 1.632-36.343, p = 0.010)] and baseline FT4 [OR=0.009 (CI: <0.001-0.313, p = 0.010)] were significantly associated with hypothyroidism in the IMRT group. Regarding dosimetric characteristics, V
60Gy [OR=1.069 (CI: 0.999-1.143, p = 0.054)] was potentially associated with the development of hypothyroidism., Conclusion: The study revealed that the incidence of hypothyroidism within 2 years after postoperative chemoradiotherapy for high-risk HNC was 16.7 % based on analytical results from prospective clinical trials., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier Ltd. All rights reserved.)- Published
- 2024
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47. Preoperative nutritional status is a useful predictor of the feasibility of postoperative treatment in octogenarian-plus pancreatic ductal adenocarcinoma patients.
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Yamada D, Takeda Y, Takahashi H, Sasaki K, Iwagami Y, Tomimaru Y, Noda T, Kobayashi S, Asaoka T, Shimizu J, Doki Y, and Eguchi H
- Abstract
Background: The suitability of radical surgery for very elderly pancreatic cancer (PC) patients remains controversial due to concerns about postoperative functional reserve. Inflammatory-nutritional status may help identify elderly patients at risk of compromised postoperative treatment tolerance., Methods: This retrospective analysis included 121 patients over eighty who were diagnosed with PC in 2010-2019, 40 of whom underwent radical surgery. Surgical outcomes were compared with those of 205 younger patients (under 80 years-old) who underwent radical surgery. K-means cluster analysis was conducted with four inflammatory-nutritional indices (NLR, PLR, PNI, and mGPS) to define, and the indices using ordinal logistic analysis were evaluated in each cluster to create a formula named 'nutritional index (NTI)', which was then used to redefine the clusters. The predictive ability of the NTI was validated in other octogenarians who underwent pancreatectomy for PC between 2020 and 2023., Results: Patients older than eighty exhibited comparable overall survival to younger patients (median survival time, 30.7/37.1 months, p = 0.20). However, octogenarian-plus patients had lower rates of adjuvant chemotherapy (AC) initiation (45/80 %) and treatment upon recurrence (52/84 %), resulting in shorter survival after recurrence (7.4/11.1 months, p = 0.06). Inflammatory-nutritional status was significantly associated with overall survival, with poor nutritional status being linked to lower rates of AC initiation and/or treatment upon recurrence. NTI effectively predicted AC feasibility., Conclusions: Radical surgery for octogenarian-plus PC patients meeting the current criteria was safe, but lower rates of postoperative treatment initiation may lead to poorer outcomes after recurrence. Inflammatory-nutritional status assessment could enhance surgical eligibility in octogenarian-plus PC patients., Competing Interests: Declaration of competing interest The authors have no conflicts of interest to declare., (Copyright © 2024. Published by Elsevier Ltd.)
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- 2024
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48. Eosinophilia During Lenalidomide Therapy in Myelodysplastic Syndrome.
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Sasaki K, Kantarjian H, Montalban-Bravo G, Hammond D, Jabbour E, Kanagal-Shamanna R, Chien K, and Garcia-Manero G
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- Humans, Male, Female, Aged, Middle Aged, Retrospective Studies, Aged, 80 and over, Adult, Lenalidomide therapeutic use, Lenalidomide adverse effects, Myelodysplastic Syndromes drug therapy, Eosinophilia chemically induced
- Abstract
Background: Lenalidomide is an immunomodulatory therapy used to treat multiple hematologic malignancies. The incidence of eosinophilia and hypereosinophilia during lenalidomide therapy, and the requirement for high-dose steroids are not well-defined PATIENTS AND METHODS: We retrospectively reviewed 44 patients with myelodysplastic syndromes who were treated with lenalidomide therapy from August 2006 and March 2023., Results: Eosinophilia (0.5-1.5 × 10
9 /L) and hypereosinophilia (>1.5 × 109 /L) were observed in 6 patients (14%) and 4 patients (9%), respectively. The median duration of lenalidomide therapy was 6.5 months. Backward multivariate ordinary logistic regression identified higher absolute eosinophil count (OR, 4759.986; 95% CI, 11.223-2018772.073; P = .006) and longer duration of lenalidomide therapy (OR, 1.148; 95% CI, 1.012-1.302; P = .032) as independent prognostic factors for the incidence of eosinophilia and hypereosinophilia. There was a trend for a higher use of high-dose steroids with hypereosinophilia. The median time to develop the first occurrence hypereosinophilia was 0.5 months. Steroids were used in 40% of patients with eosinophilia or hypereosinophilia. All events resolved with discontinuation of lenalidomide and/or use of steroids. No long-tern lasting adverse effects were recorded., Conclusion: Lenalidomide may induce or worsen existing eosinophilia which may lead to the need for steroids within a month of therapy., Competing Interests: Disclosures All authors declared no conflicts of interest related to this work. Koji Sasaki reports personal fees from Otsuka and Pfizer, outside the submitted work. Guillermo Garcia-Manero reports Gilead Sciences: Research Funding; Genentech: Honoraria, Research Funding; BMS: Consultancy, Honoraria, Research Funding; Aprea: Honoraria; AbbVie: Honoraria, Research Funding; Astex: Consultancy, Honoraria, Research Funding; Acceleron Pharma: Consultancy; Curis: Honoraria, Research Funding; Novartis: Honoraria, Research Funding. Elias Jabbour reports research funding from AbbVie, Adaptive Biotechnologies, Amgen, Bristol‐Myers Squibb, Cyclacel LTD, Pfizer, and Takeda; and personal fees from AbbVie, Adaptive Biotechnologies, Amgen, Bristol‐Myers Squibb, Pfizer, and Takeda, all outside the submitted work. Rashmi Kanagal-Shamanna received consultancy from Amgen, and Novartis, and served as Speakers Bureau for Aptitude Health, and Physicians Education Resource. Guillermo Montalban Bravo reports research funding from IFM Therapeutics. Lucia Masarova served as advisory committees at MorphoSys US. Hagop Kantarjian reports research grants and honoraria from AbbVie, Amgen, Ascentage, BMS, Daiichi-Sankyo, Immunogen, Jazz, Novartis, Pfizer and Sanofi; honoraria from Actinium (Advisory Board), Adaptive Biotechnologies, Aptitude Health, BioAscend, Delta Fly, Janssen Global, Oxford Biomedical and Takeda Oncology. WW reports Wierda:Gilead Sciences: Research Funding; Loxo Oncology, Inc./Lilly: Research Funding; Miragen: Research Funding; Bristol Meyers Squibb (Juno and Celgene): Research Funding; Kite, a Gilead Company: Research Funding; AstraZeneca/Acerta Pharma. Inc.: Research Funding; AbbVie: Research Funding; Pharmacyclics LLC: Research Funding; Sunesis: Research Funding; Xencor: Research Funding; Cyclacel: Research Funding; Genzyme: Consultancy; Genentech: Research Funding; Juno: Research Funding; Karyopharm: Research Funding; Sanofi: Consultancy; Oncternal Therapeutics, Inc.: Research Funding; Janssen: Research Funding; GSK/Novartis: Research Funding., (Copyright © 2024 Elsevier Inc. All rights reserved.)- Published
- 2024
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49. Landscape of donor cause of death and its impact on liver transplant outcomes: a ten-year analysis from the UNOS database.
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Akabane M, Imaoka Y, Esquivel CO, and Sasaki K
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- Humans, Male, Female, Middle Aged, Time Factors, Adult, Risk Factors, Treatment Outcome, Tissue and Organ Procurement, United States epidemiology, Brain Death, Donor Selection, Retrospective Studies, Risk Assessment, Liver Transplantation mortality, Tissue Donors, Databases, Factual, Graft Survival, Cause of Death
- Abstract
Background: Cause of death (COD) is a predictor of liver transplant (LT) outcomes independent of donor age, yet has not been recently reappraised., Methods: Analyzing UNOS database (2013-2022), the study explored COD trends and impacts on one-year post-LT graft survival (GS) and hazard ratios (HR) for graft failure., Results: Of 80,282 brain-death donors, 55,413(69.0%) underwent initial LT. Anoxia became the predominant COD in 2015, increasing from 29.0% in 2013 to 45.1% in 2021, with notable increases in drug intoxication. Survival differences between anoxia and cerebrovascular accidents (CVA) recently became insignificant (P=0.95). Further analysis showed improved GS from intracranial hemorrhage/stroke (previously worse; P<0.01) (P=0.70). HRs for post-1-year graft failure showed reduced significance of CVA (vs.Anoxia) and intracranial hemorrhage/stroke (vs.any other COD) recently. Donors with intracranial hemorrhage/stroke, showing improved survival and HR, were allocated to recipients with lower MELD-Na, contrasting the trend for drug intoxication CODs., Discussion: CVA, traditionally linked with poorer outcomes, shows improved GS and HRs (vs.Anoxia). This could be due to rising drug intoxication cases and the allocation of donors with drug intoxication to recipients with higher MELD-Na, and those with CVA to recipients with lower scores. While COD remains crucial in donor selection, proper matching can mitigate differences among CODs., (Copyright © 2024 International Hepato-Pancreato-Biliary Association Inc. Published by Elsevier Ltd. All rights reserved.)
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- 2024
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50. Preoperative and postoperative predictive models of early recurrence for colorectal liver metastases following chemotherapy and curative-intent one-stage hepatectomy.
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Kawashima J, Chatzipanagiotou OP, Tsilimigras DI, Khan MMM, Catalano G, Rashid Z, Khalil M, Altaf A, Munir MM, Endo Y, Woldesenbet S, Guglielmi A, Ruzzenente A, Aldrighetti L, Alexandrescu S, Kitago M, Poultsides G, Sasaki K, Aucejo F, Endo I, and Pawlik TM
- Subjects
- Humans, Male, Female, Middle Aged, Aged, Tumor Burden, Lymphatic Metastasis, Retrospective Studies, Chemotherapy, Adjuvant, Risk Assessment, Proportional Hazards Models, Hepatectomy, Liver Neoplasms secondary, Liver Neoplasms drug therapy, Liver Neoplasms surgery, Colorectal Neoplasms pathology, Neoplasm Recurrence, Local
- Abstract
Introduction: Accurate prediction of patients at risk for early recurrence (ER) among patients with colorectal liver metastases (CRLM) following preoperative chemotherapy and hepatectomy remains limited., Methods: Patients with CRLM who received chemotherapy prior to undergoing curative-intent resection between 2000 and 2020 were identified from an international multi-institutional database. Multivariable Cox regression analysis was used to assess clinicopathological factors associated with ER, and an online calculator was developed and validated., Results: Among 768 patients undergoing preoperative chemotherapy and curative-intent resection, 128 (16.7 %) patients had ER. Multivariable Cox analysis demonstrated that Eastern Cooperative Oncology Group Performance status ≥1 (HR 2.09, 95%CI 1.46-2.98), rectal cancer (HR 1.95, 95%CI 1.35-2.83), lymph node metastases (HR 2.39, 95%CI 1.60-3.56), mutated Kirsten rat sarcoma oncogene status (HR 1.95, 95%CI 1.25-3.02), increase in tumor burden score during chemotherapy (HR 1.51, 95%CI 1.03-2.24), and bilateral metastases (HR 1.94, 95%CI 1.35-2.79) were independent predictors of ER in the preoperative setting. In the postoperative model, in addition to the aforementioned factors, tumor regression grade was associated with higher hazards of ER (HR 1.91, 95%CI 1.32-2.75), while receipt of adjuvant chemotherapy was associated with lower likelihood of ER (HR 0.44, 95%CI 0.30-0.63). The discriminative accuracy of the preoperative (training: c-index: 0.77, 95%CI 0.72-0.81; internal validation: c-index: 0.79, 95%CI 0.75-0.82) and postoperative (training: c-index: 0.79, 95%CI 0.75-0.83; internal validation: c-index: 0.81, 95%CI 0.77-0.84) models was favorable (https://junkawashima.shinyapps.io/CRLMfollwingchemotherapy/)., Conclusions: Patient-, tumor- and treatment-related characteristics in the preoperative and postoperative setting were utilized to develop an online, easy-to-use risk calculator for ER following resection of CRLM., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. No funding was received for this study., (Copyright © 2024 Elsevier Ltd, BASO ~ The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved.)
- Published
- 2024
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