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Objective: To conduct a systematic review, including meta-analysis, of published randomised controlled trials (RCTs) of cumin to determine the effect on anthropometric and metabolic indices in overweight and/or type 2 diabetics, relative to controls. Methods: Studies were identified by a search of electronic databases before December 2017. Combined and stratified analyses were used. Results: Seven trials were identified, and data from 412 subjects were included. Pooled analysis showed improvements in bodyweight, body mass index (BMI) and fasting blood glucose (FBG) by −1.74 kg, −0.67 kg/m2 and −17.82 mg/dL respectively. Significant findings were also observed in triglycerides (TG) [WMD: −21.23 (95% CI: −37.64 to −4.82; P

Objective: The aim of our study was to assess the effect of ginger (Zingiber officinale) on blood glucose and lipid concentration in subjects with diabetes or hyperlipidemia. Methods: The literature search was conducted in PubMed and Scopus up to 30 October 2016. A total of nine randomized controlled trials were included in the meta-analysis. Weighted mean difference (WMD) and its 95% confidence interval were calculated for net changes in blood glucose (fasting blood-glucose [FBG]) and lipid concentrations (total cholesterol [TC], triglyceride [TG], low-density lipoprotein cholesterol [LDL-C], high density lipoprotein cholesterol [HDL-C]). Subgroup analyses were performed by clinical condition (hyperlipidemia and T2DM) and quality assessment (high and low quality). Results: Compared to the controls, ginger intake significantly reduced the concentrations of TG (WMD, −8.84; 95% CI: −11.95 to −5.73), TC (WMD, −4.42; 95% CI: −8.70 to −0.13), HDL-C (WMD, 2.87; 95% CI: 0.88–4.86) and FBG (WMD = −14.93; 95% CI: −19.83 to −10.04). Subgroup analyses by clinical condition of hyperlipidemia and high quality studies showed consistent results with the overall analysis, whereas, the subgroup analysis by clinical condition of diabetes showed a significant difference in the mean change of TG and FBG levels. Moreover, the high risk studies showed a significant change in the mean of FBG. Examining the funnel plot, suggests no publication bias. Conclusions: Ginger supplementation (tablet, capsules, powder or rhizomes) significantly reduced FBG, TG and TG and significantly increased HDL-C. But the changes were related to the clinical condition. More clinical trials evaluating the effects of ginger are warranted.