Search

Metapenaeus monoceros shell used for the removal of reactive red 2 from an aqueous solution was studied by batch biosorption system. The maximum dye uptake capacity was examined at biosorbent dosage, different pH, contact time and initial dye concentration. From the study the maximum dye uptake capacity was obtained as 166 mg/g at an optimal condition of 0.1 g/L of biosorbent dosage, pH value of 2 and initial dye concentration of 100 mg/L. When compared to the Langmuir isotherm model, the equilibrium data were fitted well with the Freundlich isotherm model. The kinetic data were fitted well with the pseudo second order rate equation when compared to the pseudo first order rate equation. The biosorbent characteristics were observed by SEM and FTIR analyses.

The modern food sector demands versatile nanocomposites of polymers for food to wrappers to inactivate germs linked to foods in order to ensure quality throughout the packaging process. Recently, it has become quite appealing to use zinc oxide nanocomposite with polyvinyl alcohol (PVA) assistance for food storage containers. Variable combinations of zinc acetate and Capparis zeylanica leaf extract (3:1, 1:7, 1:3, and 1:1) were used to create nanostructured ZnO at the desired pH (10.5). ZnO/PVA nanocomposites films were created with different weight % of (16, 13, 9 and 5%) ZnO nanoparticles by using solution casting method. The generated ZnO and ZnO/PVA nanocomposites (NCs) were characterized using analytical techniques like X-ray diffraction spectroscopy (XRD), ultraviolet spectroscopic analysis (UV-Vis), Fourier-transform infrared analysis (FT-IR), and field emission scanning electron microscopic study (FE-SEM). The generated ZnO and ZnO/PVA NCs were tested for their efficacy as antibacterial agents against Gram + ve (Streptococcus pyogenes, Staphylococcus aureus) and Gram -ve (Pseudomonas aeruginosa, and E. coli) bacteria. Under UV-visible irradiation, the methylene blue (MB) breakdown caused by the fabricated undoped ZnO and ZnO/PVA nanomixture was investigated. The FE-SEM investigation for synthesized ZnO from a 1:1 ratio exhibited spherical shaped appearance. However, the nanocomposite made with 5% ZnO showed equally scattered nanoflake particles in the matrix of PVA film as well as on the surface. The XRD results showed that ZnO synthesized with a higher proportion of plant extract produced smaller crystallites, whereas ZnO synthesized with a lower percentage of plant extract produced bigger crystallite sizes. The optimum concentration for the breakdown of methylene blue (MB) among the various concentrations examined was 5% ZnO/PVA. Furthermore, a study of the biomedical efficiency of undoped ZnO and ZnO/PVA revealed that 5% ZnO/PVA had the potential antibacterial efficacies., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 Elsevier Inc. All rights reserved.)

Titanium dioxide nanoparticles (TiO 2 NPs) are becoming more and more renowned as biocompatible nanomaterials with diverse biological functions. In the present study, the aqueous extract of tea residue (tea filtered waste powder) was used to synthesize the TiO 2 NPs and treated for effluent bioremediations. Maximum absorption in the UV-Vis spectrum of the TiO 2 NPs was seen at 358 nm, and the XRD pattern reveals peaks at 2 h values of 25.78, 38.24, 47.98, 54.76, 55.32, 62.64, 69.05, 70.15, 75.24, and 83.59 that may be indexed to the (101), (004), (200), (105), (211), (204), (116), (220), (215) and (303). The FT-IR spectra of TiO 2 NPs showed a peak at 3420, 2925, 1621, 1382, 1098, and 687 cm-1. The spherical form and size were disclosed by FE-SEM analyses, and the EDAX pattern verified the purity of the TiO 2 NPs. The average particles size of the TiO 2 NPs was 32 nm. The photodegradation of paper mill waste water is significantly deteriorated up to 99.08% for 600 min, but textile waste water is degraded up to 98.06% for the same duration. Furthermore, we reported that TiO 2 NPs may rapidly breakdown industrially hazardous effluents when exposed to sunshine. Overall, this new, straightforward, and environmentally beneficial strategy may be of interest to the management of efficient degradation of dye solutions in the polluted regions., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2022 Elsevier Inc. All rights reserved.)

Emerging clinically required α-synuclein (α-syn) inhibitor which acts as a neuroprotective nanocomposite drug is in increased demand as a patient-safe central nervous system therapeutic. This inhibitor is intended to chemically engineer graphene quantum dot (GQD) with blue luminescence, and stands to be a potential cure for Parkinson's disease. It has been theorized that α-syn aggregation is a critical step in the development of Parkinson's. Hence narrow the target by α-syn inhibition, through chemically synthesize methyl N-allyl N-benzoylmethioninate (MABM) and functionally engineer the surface of GQD to target the brain delivery on C57BL/6 mice. Spectroscopic and simulation studies confirm defibrillation through the interaction between N-terminal amino acids and MABM-GQD nanoparticles, which makes nontoxic α-syn. Therefore, this drug's ability to cross the blood-brain barrier in vitro functionally prevents neuronal loss in neuroblastoma cells. Thus, in vivo cerebral blood flow analysis using magnetic resonance imaging illustrates, how this nanocomposite can possibly treat Parkinson's., Competing Interests: Declaration of competing interest The authors declare no conflict of interest., (Copyright © 2022 Elsevier Inc. All rights reserved.)

The utmost aim of this present study was to investigate the anti-inflammatory, antiproliferative and proapoptotic potential of Asiatic acid (AA) on 1,2-dimethylhydrazine (DMH)-induced colon carcinogenesis in experimental rats. Rats were divided into six groups and received modified pellet diet for 32 weeks. Group 1 served as control rats. Group 2 received AA (4 mg/kg b.w. p.o.). Group 3-6 rats received 15 DMH (20 mg/kg b.w., s.c.) injections once a week starting from the 4th week. Besides DMH, rats received AA (4 mg/kg b.w. p.o.) in group 4 starting 2 weeks before carcinogen treatment till the end of the last DMH; group 5 starting 2 days after last DMH till the end of the experiment; and group 6 throughout the experiment. Pre-neoplastic lesions, xenobiotic metabolizing enzymes, inflammation, cell proliferation and apoptotic markers were analysed in our study. Our results ascertained AA supplementation to DMH-exposed rats significantly decreased the incidence of aberrant crypt foci (ACF) and phase I xenobiotic enzymes; and increased the phase II xenobiotic enzymes and mucin content as compared to DMH-alone-exposed rats. Moreover the increased expressions of mast cells, argyrophilic nucleolar organizer regions (AgNORs), proliferating cell nuclear antigen (PCNA) and cyclin D1 observed in the DMH-alone-exposed rats were reverted and were comparable with those of the control rats, when treated with AA. Concordantly AA also induced apoptosis by downregulating the expression of Bcl-2 and upregulating Bax, cytochrome c, caspase-3 and -9 in the DMH-alone-exposed rats. Thus AA was able to inhibit DMH-induced colon carcinogenesis by detoxifying the carcinogen, decreasing the preneoplastic lesions by virtue of its anti-inflammatory, antiproliferative and proapoptotic effects. Therefore our findings suggest that AA could be used as an effective chemopreventive agent against DMH induced colon carcinogenesis., (Copyright © 2017 Elsevier B.V. All rights reserved.)