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From the latest vaccination evidence, recommendations, and protocols... to new vaccine development and the use of vaccines in reducing disease, Plotkin's Vaccines, 8th Edition, covers every aspect of vaccination. Now completely revised and updated from cover to cover, this award-winning text continues to provide reliable information from global authorities, offering a complete understanding of each disease, as well as the latest knowledge of both existing vaccines and those currently in research and development. Described by Bill Gates as'an indispensable guide to the enhancement of the well-being of our world,'Plotkin's Vaccines is a must-have reference for current, authoritative information in this fast-moving field. Contains all-new chapters on COVID-19, vaccine hesitancy, and non-specific effects of vaccines, as well as significantly revised content on new vaccine technologies such as mRNA vaccines, emerging vaccines, and technologies to improve immunization. Presents exciting new data on evolution of adjuvants across the centuries, dengue vaccines, human papillomavirus vaccines, respiratory syncytial virus vaccines, tuberculosis vaccines, and zoster vaccines. Provides up-to-date, authoritative information on vaccine production, available preparations, efficacy and safety, and recommendations for vaccine use, with rationales and data on the impact of vaccination programs on morbidity and mortality. Provides complete coverage of each disease, including clinical characteristics, microbiology, pathogenesis, diagnosis, and treatment, as well as epidemiology and public health and regulatory issues. Keeps you up to date with information on each vaccine, including its stability, immunogenicity, efficacy, duration of immunity, adverse events, indications, contraindications, precautions, administration with other vaccines, and disease-control strategies. Covers vaccine-preventable diseases, vaccine science, and licensed vaccine products, as well as product technologies and global regulatory and public health issues. Analyzes the cost-benefit and cost-effectiveness of different vaccine options. Helps you clearly visualize concepts and objective data through an abundance of tables and figures. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

While medical specialists in disaster mitigation, preparedness, and response are needed worldwide, the initial phase of disaster response is almost entirely dependent upon local resources—making it essential that all healthcare personnel have a working knowledge of the field and stand ready to integrate into the response system. Ciottone's Disaster Medicine, 3rd Edition, is the most comprehensive reference available to help accomplish these goals in every community. It thoroughly covers isolated domestic events as well as global disasters and humanitarian crises. Dr. Gregory Ciottone and more than 200 worldwide authorities share their knowledge and expertise on the preparation, assessment, and management of both natural and man-made disasters, including lessons learned by the responders to contemporary disasters such as the COVID-19 pandemic, Australian and western U.S. wildfires, European heatwaves, the Beirut explosion, recent hurricanes and typhoons, and the global refugee crisis. Part 1 offers an A-to-Z resource for every aspect of disaster medicine and management, while Part 2 features an exhaustive compilation of every conceivable disaster event, organized to facilitate quick reference in a real-time setting. Covers basic concepts such as identification of risks, organizational preparedness, equipment planning, disaster education and training, and more advanced concepts such as disaster risk reduction, health in complex emergencies, building local disaster resiliency, psychological impact of disasters on children, and more. Contains new decision trees throughout that help guide you through the decision-making process in difficult situations. Uses an easy-to-follow, templated approach to historical perspectives, overviews of current practice including pre-incident and post-incident actions, medical treatment of casualties, and potential pitfalls. Includes updated sections on man-made disasters, including mass casualties, active shooter situations, integrated response to terrorist attacks, and chemical/biological/radiological/nuclear/high-yield explosives disasters. Discusses the latest technologies, such as the use of mobile disaster applications, drone response systems, and virtual reality simulation training. Features thoroughly updated information on crisis leadership, practical applications of disaster epidemiology, disaster and climate change, and the integration of non-government agencies (NGOs) in disaster response—a critical topic for those responding to humanitarian needs overseas. Includes new chapters on Pandemic Preparedness and Response, Disaster Medicine in a Changing Climate, Disaster Response in Asia, Building Local Capacity and Disaster Resiliency, Civilian-Military Coordination in Disaster Response, Medical Simulation in Disaster Preparedness, Disaster Nursing, Crisis Meta-Leadership, Palliative Care in Disasters, Counter-Terrorism Medicine, SARS CoV (COVID-19 and SARS), and Disasters in Space Travel. An eBook version is included with purchase. The eBook allows you to access all of the text, figures and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud.

For 125 years, physicians have relied on Manson's Tropical Diseases for a comprehensive clinical overview of this complex and fast-changing field. The fully revised 24th Edition, Dr. Jeremy Farrar, along with an internationally recognized editorial team, global contributors, and expert authors, delivers the latest coverage on parasitic and infectious diseases from around the world. From the difficult to diagnose to the difficult to treat, this highly readable, award-winning reference prepares you to effectively handle whatever your patients may have contracted. Covers all of tropical medicine in a comprehensive manner, general medicine in the tropics, and non-clinical issues regarding public health and ethics. Serves as an indispensable resource for physicians who treat patients with tropical diseases and/or will be travelling to the tropics, or who are teaching others in this area. Contains a new section on 21st Century Drivers of Tropical Medicine, with chapters covering Poverty and Inequality, Public Health in Settings of Conflict and Political Instability, Climate Change, and Medical Product Quality and Public Health. Includes all-new chapters on Surgery in the Topics, Yellow Fever, Systemic Mycoses, and COVID-19. Covers key topics such as drug resistance; emerging and reemerging infections such as Zika, Ebola, and Chikungunya; novel diagnostics such as PCR-based methods; point-of care-tests such as ultrasound; public health in settings of conflict and political instability; and much more. Differentiates approaches for resource-rich and resource-poor areas. Includes reader-friendly features such as highlighted key information, convenient boxes and tables, extensive cross-referencing, and clinical management diagrams.

Encyclopedia of Infection and Immunity, Four Volume Set provides new insights into the interactions between bacteria, fungi, parasites and their hosts. Specific areas of interest include host cellular and immune response to microbes, molecular mechanisms of action of beneficial microbes or host-associated microbial communities, microbial pathogenesis, virulence factors, experimental models of infection, host resistance or susceptibility, and the generation of innate and adaptive immune responses. Comprised of over 200 chapters written and edited by leading experts in the field, this book will serve as a key resource for students, researchers, academics and industry practitioners in the fields of microbiology, immunology, and infectious diseases. More than 100 years after Robert Koch and Louis Pasteur established the microbial etiology of communicable diseases, the field of microbiology is experiencing a second period of rapid growth and expansion, driven by the realization that changes in host-associated microbial communities might be at the root of a broad spectrum of noncommunicable human diseases. These advances follow on the heels of recent progress in high-throughput sequencing technology, which has provided a wealth of information on the human microbiome and its physiological potential. 2023 PROSE Awards - Winner: Finalist: Reference Works – Biological and Life Sciences: Association of American Publishers Offers a contemporary review of current infection and immunity research, and insights into the future direction of the field Meticulously researched and cross-referenced to allow students, researchers and professionals to find relevant information quickly and easily Includes chapters written by academics and practitioners from various fields and regions, ensuring that the knowledge within is easily understood by, and applicable to, a large audience

Offering a comprehensive review of the neuropathology of SARS-CoV-2, Neurological Care and the COVID-19 Pandemic provides up-to-date coverage of the wide array of the pathogen's neurological symptoms and complications. Drs. Ahmad Riad Ramadan and Gamaledin Osman discuss the neuropathology of SARS-CoV-2, its neurological manifestations, and the impact the pandemic has had on the care of patients with pre-existing neurological conditions. The authors also offer an overview of emerging treatments and vaccines, as well as ways healthcare systems have reorganized in order to respond to the pandemic. Offers a thorough discussion of the impact the virus has had on the care of patients with neurological ailments, accompanied by recommendations on how to care for these patients. Covers the impact of COVID-19 on patients with cerebrovascular diseases, seizures, demyelinating diseases, neuromuscular disorders, movement disorders, headache disorders, cognitive disorders, and neuro-oncological disorders. Includes a detailed case study of how one healthcare system hit hard by COVID-19 successfully transformed itself to respond to the challenges imposed by the pandemic. Consolidates today's available information on this timely topic into a single, convenient resource.

Offering up-to-date coverage of familiar flaviviruses that are spreading into new regions or are causing increasingly severe disease, as well as viruses that are almost unknown in most developed nations, Zika and Other Neglected and Emerging Flaviviruses brings together information that allows for easy comparison of similarities and differences of this viral group in a single, convenient volume. Each chapter includes a brief Introduction, history, the diseases, the virus, the immune response, prevention or treatment, an extensive list of references, and a summary overview. The book concludes with a chapter tying together information about flaviviruses and other potential new microbial threats. Covers familiar flaviviruses that are spreading into new regions or are causing increasingly severe disease (such as Zika, dengue and West Nile viruses), as well as lesser-knowns viruses such as tick-borne encephalitis virus, Powassan virus, Omsk hemorrhagic fever, and Murray Valley encephalitis virus. Allows health-related personnel to search for potential treatments and protective responses by examining what measure did or did not work with other, related flaviviruses. Helps readers understand how to prevent or contain newly emerging viral threats—a particularly timely topic regarding the global spread of COVID-19 and the potential of tick-borne encephalitis to rapidly spread and cause severe illness, panic, and disruption of economies. Consolidates today's available information on this timely topic into a single, convenient resource.

Nanostructures for Antimicrobial Therapy discusses the pros and cons of the use of nanostructured materials in the prevention and eradication of infections, highlighting the efficient microbicidal effect of nanoparticles against antibiotic-resistant pathogens and biofilms. Conventional antibiotics are becoming ineffective towards microorganisms due to their widespread and often inappropriate use. As a result, the development of antibiotic resistance in microorganisms is increasingly being reported. New approaches are needed to confront the rising issues related to infectious diseases. The merging of biomaterials, such as chitosan, carrageenan, gelatin, poly (lactic-co-glycolic acid) with nanotechnology provides a promising platform for antimicrobial therapy as it provides a controlled way to target cells and induce the desired response without the adverse effects common to many traditional treatments. Nanoparticles represent one of the most promising therapeutic treatments to the problem caused by infectious micro-organisms resistant to traditional therapies. This volume discusses this promise in detail, and also discusses what challenges the greater use of nanoparticles might pose to medical professionals. The unique physiochemical properties of nanoparticles, combined with their growth inhibitory capacity against microbes has led to the upsurge in the research on nanoparticles as antimicrobials. The importance of bactericidal nanobiomaterials study will likely increase as development of resistant strains of bacteria against most potent antibiotics continues. Shows how nanoantibiotics can be used to more effectively treat disease Discusses the advantages and issues of a variety of different nanoantibiotics, enabling medics to select which best meets their needs Provides a cogent summary of recent developments in this field, allowing readers to quickly familiarize themselves with this topic area

This issue of Infectious Disease Clinics of North America, Guest Edited by Paul Auwaerter, MD, is devoted to Lyme Disease. Dr. Auwaerter has assembled a group of expert authors to review the following topics: Epidemiology of Lyme Disease; Early Lyme disease: Erythema Migrans; Neuroborreliosis; Lyme Carditis; Lyme Arthritis; Pediatric Lyme Disease; Diagnostics of Lyme Disease; Post-treatment Lyme Disease Syndrome; Chronic Lyme Disease; Co-infection: Human Granulocytic Ehrlichiosis; Co-infection: Babesiosis; and Emerging Tick-borne infections: Borrelia miyamotoi, Powassan/Deer Tick virus, Heartland virus, Bartonella.

This volume in the Handbook of Clinical Neurology series provides a complete review of the history, science and current state of neurovirology. It covers the science and clinical presentation, diagnosis, and treatment of viruses of the brain and central nervous system, and is a trusted resource for scholars, scientists, neuroscientists, neurologists, virologists, and pharmacologists working on neurovirology. Neurovirology has been significantly bolstered by modern technologies such as PCR and MRI with direct impact on isolating viruses and advancing therapeutics based on molecular medicine. These advances are particularly important today with the introduction of emerging and re-emerging diseases such as HIV/AIDS, Nipah encephalitis and the appearance of West Nile encephalitis in the western hemisphere. Detailed coverage of neurovirology from the basic science to clinical presentation Covers advances in neurovirology via polymerase chain reaction (PCR) and MRI technology Covers emerging and re-emerging diseases including HIV/AIDS, Nipah encephalitis, and the appearance of West Nile encephalitis in the western hemisphere

Nueva edición de la referencia mundialmente reconocida en pediatría, y obra de primera elección para todos los profesionales que desarrollan su actividad clínica en este campo. Una vez más se presenta bajo la marca Nelson la obra que durante sus 18 ediciones se ha convertido en el bestseller indiscutible en el campo de la pediatría. La nueva edición se presenta en 2 volúmenes, y es de destacar que se ha hecho un importante esfuerzo, por parte de los autores, en no sólo mantener la extensión, sino en disminuirla ligeramente. Dicha reducción en la extensión ha sido debida a dos hechos fundamentalmente: Paso de la parte relativa a ciencias básicas, más propias de un libro de texto para los estudiantes, a formato online exclusivamente; Rediseño de todas las figuras de la obra, ya que en un principio estaban en su mayoría sobredimensionadas. Los principales objetivos de la obra son: Facilitar la comprensión de las bases terapéuticas y de qué fármacos y en qué dosis deben administrarse ante cada una de las patologías reflejadas. Proporcionar un acceso fácil y rápido a la información, gracias a un magnífico diseño y a una gran cantidad de figuras (1.800 a todo color). La nueva edición, totalmente actualizada, recoge las últimas novedades en genética, neurología, enfermedades infecciosas, envenenamiento por melamina, identidad sexual, homosexualidad en la adolescencia, aspectos psicóticos relacionados con la epilepsia, etc. Igualmente, aborda de una forma totalmente novedosa el tratamiento de los trastornos genéticos, la ventilación mecánica de larga duración en los niños agudos y alteraciones del comportamiento relacionados con la edad. A lo largo de la obra se refleja también la transición del niño con enfermedad crónica a adulto joven y los cuidados que éstos requieren (enfermedades como la fibrosis quística, diabetes y malformaciones cardíacas congénitas). Se observa también una importante reorganización de la Sección dedicada a la pediatría dermatológica, con un texto mucho más intuitivo, que facilita su comprensión.Esta nueva edición ofrece acceso a ExpertConsult en inglés en donde aparte de todo el texto y las imágenes (1.800 a todo color) incluye referencias a artículos científicos, acceso a revistas, y un enlace a un vademécum online para poder disponer de la información más reciente sobre fármacos y posologías. Paralelamente, se ofrece acceso a StudentConsult.es en donde se pueden consultar todos aquellos textos adicionales en español que complementan a los diferentes capítulos.

Desde el año 1927, Cecil Tratado de Medicina Interna ha sido la obra de referencia en este campo. Permite comprender de manera óptima cómo diagnosticar y tratar cualquier trastorno médico que se encuentra en la práctica. Integra hábilmente los últimos avances en biología con el diagnóstico y las terapias actuales, basados en la evidencia, incluyendo dosis farmacológicas. Su formato dinámico y bien organizado ofrece un acceso rápido a la información de referencia. Como novedades destancan: la inclusión de un nuevo capítulo de Aplicación de tecnologías moleculares a la medicina clínica, una sección completamente renovada de enfermedades infecciosas y cobertura de las más novedosas técnicas y tratamientos cardiovasculares.Cuenta con multitud de contenidos en linea, en inglés, como figuras complementarias, tablas, algoritmos, referencias, vídeos de procedimientos o casos de estudio.