1. Neuroimmunomodulatory effect of Nitric Oxide on chronic wound healing after photodynamic therapy.
- Author
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Nardini P, Notari L, Magazzini M, Mariani B, Rossi F, Rossi S, Van Aardt E, Marszalek K, Grandi V, Corsi A, Pimpinelli N, and Bacci S
- Subjects
- Humans, Neuroimmunomodulation drug effects, Neuroimmunomodulation physiology, Prospective Studies, Nitric Oxide metabolism, Photochemotherapy methods, Photosensitizing Agents pharmacology, Photosensitizing Agents therapeutic use, Wound Healing drug effects, Wound Healing physiology
- Abstract
Neuroimmunomodulation is the capacity of the nervous system to regulate immune processes. The existence of neurotransmitter receptors in immune cells enables this phenomenon to take place. Neuronal mediators possess the capacity to direct and control several occurrences during the wound healing process. Nitric oxide (NO) functions as a neuromodulator, playing a crucial role in the regulation of vascular tone and blood pressure with antimicrobial properties. Photodynamic therapy has been shown to augment the function of immune cells involved in the healing process of venous leg ulcers. Nitric oxide can be secreted into the extracellular environment by these cells. In lesions treated with PDT, the synthesis of iNOs (the enzyme that releases NO) increased, as demonstrated by the experimental results. Therefore the significance of PDT in enhancing the clinical condition of the lesion is thus highlighted., Competing Interests: Declaration of competing interest The authors declare no conflicts of interest., (Copyright © 2024 The Author(s). Published by Elsevier B.V. All rights reserved.)
- Published
- 2024
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