1. Hypothyroidism does not lead to worse prognosis in COVID-19: findings from the Brazilian COVID-19 registry
- Author
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Daniella Nunes Pereira, Leticia Ferreira Gontijo Silveira, MD, PhD, Milena Maria Moreira Guimarães, Carísi Anne Polanczyk, Aline Gabrielle Sousa Nunes, André Soares de Moura Costa, Barbara Lopes Farace, Christiane Corrêa Rodrigues Cimini, Cíntia Alcantara de Carvalho, Daniela Ponce, Eliane Würdig Roesch, Euler Roberto Fernandes Manenti, Fernanda Barbosa Lucas, Fernanda d'Athayde Rodrigues, Fernando Anschau, Fernando Graça Aranha, Frederico Bartolazzi, Giovanna Grunewald Vietta, Guilherme Fagundes Nascimento, Helena Duani, Heloisa Reniers Vianna, Henrique Cerqueira Guimarães, Jamille Hemétrio Salles Martins Costa, Joanna d'Arc Lyra Batista, Joice Coutinho de Alvarenga, José Miguel Chatkin, Júlia Drumond Parreiras de Morais, Juliana Machado-Rugolo, Karen Brasil Ruschel, Lílian Santos Pinheiro, Luanna Silva Monteiro Menezes, Luciana Siuves Ferreira Couto, Luciane Kopittke, Luís César de Castro, Luiz Antônio Nasi, Máderson Alvares de Souza Cabral, Maiara Anschau Floriani, Maíra Dias Souza, Marcelo Carneiro, Maria Aparecida Camargos Bicalho, Mariana Frizzo de Godoy, Matheus Carvalho Alves Nogueira, Milton Henriques Guimarães Júnior, Natália da Cunha Severino Sampaio, Neimy Ramos de Oliveira, Pedro Ledic Assaf, Renan Goulart Finger, Roberta Xavier Campos, Rochele Mosmann Menezes, Saionara Cristina Francisco, Samuel Penchel Alvarenga, Silvana Mangeon Mereilles Guimarães, Silvia Ferreira Araújo, Talita Fischer Oliveira, Thulio Henrique Oliveira Diniz, Yuri Carlotto Ramires, Evelin Paola de Almeida Cenci, Thainara Conceição de Oliveira, Alexandre Vargas Schwarzbold, Patricia Klarmann Ziegelmann, Roberta Pozza, Caroline Scherer Carvalho, Magda Carvalho Pires, and Milena Soriano Marcolino
- Subjects
Hypothyroidism ,COVID-19 ,Mortality ,Prognosis ,Epidemiology ,Infectious and parasitic diseases ,RC109-216 - Abstract
Background: It is not clear whether previous thyroid diseases influence the course and outcomes of COVID-19. Methods: The study is a part of a multicentric cohort of patients with confirmed COVID-19 diagnosis from 37 hospitals. Matching for age, sex, number of comorbidities, and hospital was performed for the paired analysis. Results: Of 7,762 patients with COVID-19, 526 had previously diagnosed hypothyroidism and 526 were matched controls. The median age was 70 years, and 68.3% were females. The prevalence of comorbidities was similar, except for coronary and chronic kidney diseases that were higher in the hypothyroidism group (p=0.015 and p=0.001). D-dimer levels were lower in patients with hypothyroid (p=0.037). In-hospital management was similar, but hospital length-of-stay (p=0.029) and mechanical ventilation requirement (p=0.006) were lower for patients with hypothyroidism. There was a trend of lower in-hospital mortality in patients with hypothyroidism (22.1% vs 27.0%; p=0.062). Conclusion: Patients with hypothyroidism had a lower requirement of mechanical ventilation and showed a trend of lower in-hospital mortality. Therefore, hypothyroidism does not seem to be associated with a worse prognosis.
- Published
- 2022
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