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Purpose: Parental severe mental illness (SMI) is associated with an increased risk of offspring autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD). We conducted a study to examine the extent to which risk of preterm birth, low birth weight, and small for gestational age mediated this association., Methods: We obtained data on offspring born 1992-2001 in Sweden (n = 870,017) through the linkage of multiple population-based registers. We used logistic and Cox regression to assess the associations between parental SMI, adverse pregnancy outcomes, and offspring ASD and ADHD, as well as tested whether adverse pregnancy outcomes served as mediators., Results: After controlling for measured covariates, maternal and paternal SMI were associated with an increased risk for preterm birth, low birth weight, and gestational age, and for offspring ASD and ADHD. These pregnancy outcomes were also associated with an increased risk of ASD and ADHD. We found that pregnancy outcomes did not mediate the association between parental SMI and offspring ASD and ADHD, as there was no substantial change in magnitude of the risk estimates after controlling for pregnancy outcomes., Conclusions: Parental SMI and adverse pregnancy outcomes appear to be independent risk factors for offspring ASD and ADHD., (Copyright © 2014 Elsevier Inc. All rights reserved.)

Purpose: Electronic data capture is becoming increasingly common for collecting real-time patient responses. The purpose of this study was to investigate compliance with a daily electronic questionnaire regarding night-time contact lens visual performance., Method: Forty-eight subjects (34 females) were fit and dispensed two contralateral pairs of soft contact lenses (SCLs) for one week each. Subjects were sent a nightly e-mail at 8PM containing a secure, individualized link to an electronic questionnaire asking 30 questions of varying response styles (e.g., multiple choice, short answer, etc.) about SCL visual performance. Subjects were instructed to complete the questionnaire before going to bed., Results: The overall completion rate based on 676 electronic questionnaires was 95.1%. Of these, only 3.6% were completed late (<24h). The percentage of subjects completing all questionnaires was significantly higher on weekdays (96.5%; Sunday through Thursday) than on weekends (91.1%; Friday and Saturday). Fisher exact tests indicated no significant association with gender for either weekday (p=0.25) or weekend (p=0.73). Although odds ratio estimates suggested that participants 23 and older were more likely to complete the questionnaire (weekday: OR=4.39, p=0.10; weekend: OR=2.93, p=0.19), these associations did not reach statistical significance., Conclusions: E-mail based questionnaires provide an effective method for acquiring time specific responses, making them a viable clinical and research tool. The day(s) of the week on which assessments occur need to be strongly considered, as on-time compliance may be affected on weekend evenings, or possibly situations in which a typical schedule may not be followed., (Copyright © 2012 British Contact Lens Association. Published by Elsevier Ltd. All rights reserved.)

Purpose: Patient-reported subjective responses have become increasingly popular in describing contact lens visual performance and discriminating between designs. The purpose of the current study is to evaluate the ability of patient-reported measures of vision to quantify the perceptual effects of defocus., Methods: Ten young (18-35 years) subjects rated their subjective visual performance monocularly on 3 scales following wear of their optimal monocular distance correction and nine different blurring lenses (-0.50 to +1.50 in 0.25 D steps) in a trial frame. The three scales used were a 0-100 numeric rating scale (NRS), a 100 mm visual analog scale (VAS), and a 5 point ("Poor", "Fair", "Average", "Good", "Excellent") categorical rating scale (CRS)., Results: Mixed linear modeling results found no significant effects either for eye or trial number, but did find a significant effect due to blurring lens power (p<0.0001), with ratings decreasing with increasing levels of blur for all scales. Results were not significantly different between the NRS and VAS at any level of blur, with limits of agreement falling within 22% of the measurement scale. CRS ratings were about 15 units lower than the other scales on average, with limits of agreement that varied with lens power and were roughly 3 times as large. Across scale internal consistency was 0.94., Conclusions: The NRS and VAS yield virtually identical rating responses, but both differing slightly, however from the CRS. Each scale successfully discriminated levels of blur smaller than 0.25 D with only a single measurement., (Copyright © 2012 British Contact Lens Association. Published by Elsevier Ltd. All rights reserved.)