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Your search keyword '"Rathipriya, R."' showing total 5 results
Start Over Author "Rathipriya, R." Publisher elsevier
5 results on '"Rathipriya, R."'

1. Contributors

Author

Acharya, Soutrik, primary, Ahmed, Kowshik, additional, Al-Dabass, David, additional, Anisha Kumari, K., additional, Annappa, B., additional, Baik, Sung Wook, additional, Behera, H.S., additional, Bishi, Dillip Kumar, additional, Cannella, Roberto, additional, Cetin, Onursal, additional, Das, Asit Kumar, additional, Dash, Pandit Byomakesha, additional, Dodia, Shubham, additional, Ghosh, Dyuti, additional, Ghosh, Uttam, additional, Gorur, Kutlucan, additional, Gowri, R., additional, Haq, Ijaz Ul, additional, Jeyaraj, Pandia Rajan, additional, Kumar, Pemmada Suresh, additional, Lagalla, Roberto, additional, Liu, Shuai, additional, Liu, Xiangbin, additional, Midiri, Massimo, additional, Min Ullah, Fath U, additional, Mishra, Manohar, additional, Mohapatra, Subhashree, additional, Muhammad, Khan, additional, Nadar, Edward Rajan Samuel, additional, Naik, Bighnaraj, additional, Nayak, Debasish Swapnesh Kumar, additional, Nayak, Janmenjoy, additional, Nayak, SoumyaRanjan, additional, Oram, Etuari, additional, Ozer, Ilyas, additional, Padhi, Priyadarshini, additional, Panigrahi, Bijaya Ketan, additional, Panigrahi, Chhabi Rani, additional, Pati, Bibudhendu, additional, Pelusi, Danilo, additional, Rath, Chandi Charan, additional, Rathipriya, R., additional, Reddy, Dukka Karun Kumar, additional, Ripon, Shamim H., additional, Sahani, Mrutyunjaya, additional, Sharma, Renu, additional, Shibly, Mir Moynuddin Ahmed, additional, Song, Liping, additional, Swain, Bhanja Kishor, additional, Swapnarekha, H., additional, Swarnkar, Tripti, additional, Temurtas, Feyzullah, additional, Tisha, Tahmina Akter, additional, Vernuccio, Federica, additional, and Vimal, S., additional

Published
2023
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3. List of contributors

Author

Abohany, Amr, primary, Ali, Ahmed F., additional, AlRubaiei, Mazoon, additional, Darwish, Ashraf, additional, Dhamodharavadhani, S., additional, El-Shafeiy, Engy, additional, Jassim, Hothefa sh, additional, Juma, Mazen, additional, Kaur, Avinash, additional, Malallah, Fahad Layth, additional, Mathew, Elezabeth, additional, Nayyar, Anand, additional, Panigrahi, Chhabi Rani, additional, Pati, Bibudhendu, additional, Pattanayak, Binod Kumar, additional, Raslan, Aliaa F., additional, Rath, Mamata, additional, Rathipriya, R., additional, Safdar, Sohail, additional, Shaalan, Khaled, additional, Sharef, Baraa T., additional, Sharef, Zeyad T., additional, Singh, Parminder, additional, and Sivabalan, S., additional

Published
2020
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5. E3 Ubiquitin-Protein Ligase SMURF1 in the Nucleus Accumbens Mediates Cocaine Seeking.

Author

Werner CT, Viswanathan R, Martin JA, Gobira PH, Mitra S, Thomas SA, Wang ZJ, Liu JF, Stewart AF, Neve RL, Li JX, Gancarz AM, and Dietz DM

Subjects
Animals, Cocaine-Related Disorders genetics, Cues, Male, Nucleus Accumbens drug effects, Proteasome Endopeptidase Complex, Rats, Rats, Sprague-Dawley, Self Administration, Signal Transduction, Smad1 Protein genetics, Ubiquitin-Protein Ligases genetics, Cocaine administration & dosage, Drug-Seeking Behavior physiology, Nucleus Accumbens physiology, Smad1 Protein physiology, Ubiquitin-Protein Ligases physiology
Abstract

Background: Substance use disorder is a neurobiological disease characterized by episodes of relapse despite periods of withdrawal. It is thought that neuroadaptations in discrete brain areas of the reward pathway, including the nucleus accumbens, underlie these aberrant behaviors. The ubiquitin-proteasome system degrades proteins and has been shown to be involved in cocaine-induced plasticity, but the role of E3 ubiquitin ligases, which conjugate ubiquitin to substrates, is unknown. Here, we examined E3 ubiquitin-protein ligase SMURF1 (SMURF1) in neuroadaptations and relapse behavior during withdrawal following cocaine self-administration., Methods: SMURF1 and downstream targets ras homolog gene family, member A (RhoA), SMAD1/5, and Runt-related transcript factor 2 were examined using Western blotting (n = 9-11/group), quantitative polymerase chain reaction (n = 6-9/group), co-immunoprecipitation (n = 9-11/group), tandem ubiquitin binding entities affinity purification (n = 5-6/group), and quantitative chromatin immunoprecipitation (n = 3-6/group) (2 rats/sample). Viral-mediated gene transfer (n = 7-12/group) and intra-accumbal microinjections (n = 9-10/group) were used to examine causal roles of SMURF1 and substrate RhoA, respectively, in cue-induced cocaine seeking., Results: SMURF1 protein expression was decreased, while SMURF1 substrates RhoA and SMAD1/5 were increased, in the nucleus accumbens on withdrawal day 7, but not on withdrawal day 1, following cocaine self-administration. Viral-mediated gene transfer of Smurf1 or constitutive activation of RhoA attenuated cue-induced cocaine seeking, while catalytically inactive Smurf1 enhanced cocaine seeking. Furthermore, SMURF1-regulated, SMAD1/5-associated transcription factor Runt-related transcript factor 2 displayed increased binding at promoter regions of genes previously associated with cocaine-induced plasticity., Conclusions: SMURF1 is a key mediator of neuroadaptations in the nucleus accumbens following cocaine exposure and mediates cue-induced cocaine seeking during withdrawal., (Copyright © 2018 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.)

Published
2018
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