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Annealing usually induces structural relaxation and reduction of liquid-like regions, leading to embrittlement in bulk metallic glasses (BMGs). Here, we find that the short-term high-temperature thermal cycling (HTC) annealed Zr41.2Ti13.8Cu12.5Ni10Be22.5 (Vit1) BMG shows an improved plasticity without sacrificing their yield strength. And only relaxation behavior with increased hardness is observed after HTC, which is different from the rejuvenation effect usually observed in cryogenic thermal cycling (CTC). We revealed that this embrittlement reversal is attributed to enhanced fluctuations of full width at half maximum (FWHM) of the hardness’ distribution at micrometer and larger scales induced by short-term HTC. The enhanced fluctuations of mechanical heterogeneities across the diameter on a cross-section of the short-term HTC sample may increase the number and decrease the size of shear transformation zones (STZs) activated at high stress and promote the deflection of shear bands (SBs) during their propagation to form multiple SBs. The enhanced plasticity after HTC induced relaxation contradicts the common sense that relaxation accompanying with annihilation of free volume or liquid-like region usually causes embrittlement. Present results indicate that short-term HTC could be a powerful mean to tune the mechanical performance, shedding new lights on the interplay among relaxation, mechanical/structural heterogeneity, and plasticity of MGs.

Social stress, a common stressor, causes multiple forms of physical and mental dysfunction. Prolonged exposure to social stress is associated with a higher risk of psychological disorders, including anxiety disorders and major depressive disorder (MDD). The orexinergic system is involved in the regulation of multiple motivated behaviors. The current study examined the regulatory effect of orexinergic projections from the lateral hypothalamic area (LHA) to the lateral habenula (LHb) in depression- and anxiety-like behaviors after chronic social defeat stress. When mice were defeated during social interaction, both orexinergic neurons in the LHA and glutamatergic neurons in the LHb were strongly activated, as indicated by the FosTRAP strategy. Infusion of orexin in the LHb significantly alleviated social avoidance and depression-like behaviors induced by chronic social defeat stress. Administration of an orexin receptor 2 antagonist in the LHb further aggravated the depressive phenotype. Photoactivation of orexinergic cell bodies in the LHA or terminals in the LHb relieved anxiety-like behaviors induced by chronic social defeat stress. Collectively, we identified the antidepressant and anxiolytic effects of the circuit from LHA orexinergic neurons to the LHb in response to chronic social stress, providing new evidence of the antidepressant properties of LHA orexin circuits.