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In the current study, the Sonogashira coupling reaction of danazol with aryl halides was carried out, yielding new aryl substituted danazol derivatives. The synthetic compounds were examined for anti-cancer potential on the HeLa human cervical cancer cell line, and they showed promising cytotoxic action. Synthesized compounds 2, 4 and 5 inhibited the growth of HeLa cervical cancer cells, potentially making them effective anti-cancer drugs in the future. Furthermore, molecular docking studies were performed to evaluate the inhibitory impact of danazol derivatives on the Human Papillomavirus (HPV) target protein (1F9F). The docking results showed a significant inhibitory action against the cervical cancer protein (1F9F). The binding energy (ΔG) values of 1, 2, 3, 4 and 5 against the protein 1F9F were -8.01, -8.70, -9.43, -9.58 and -9.75 kcal/mol, indicating a high affinity of the synthesized compounds to bind with the HPV target proteins compared to their parent compound danazol (1). ADMET analyses of all derivatives have also been carried out., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier Inc. All rights reserved.)

Quinclorac (QNC) is an effective but environmentally persistent herbicide commonly used in rice production. However, few studies have investigated its environmental behavior and degradation. In the present study, we carried out microbial cultures in the presence of QNC to observe changes in soil microbiota and to identify species capable of QNC degradation by using high-throughput sequencing of the 16S rRNA. Pseudomonas was the dominant genus, and Pseudomonas putida II-2 and other species were found to be capable of mineralizing QNC as a source of carbon and energy. However, this degradation rate was slow, only reaching 51.5 ± 1.6% for 7 days at 30 °C on QNC + minimal salt medium. Achromobacter sp. QC36 co-metabolized QNC when rice straw was added into the mineral salt medium containing QNC, and a mixed culture of both strains could mineralize approximately 92% of the 50 mg/L QNC after 5 days of cultivation in the presence of rice straw, at 25-35 °C and pH 6.0-8.0. Non-phytotoxicity of tobacco after degradation of QNC by mixed strains was evidenced in a pot experiment. These results suggest that this mixed culture may be useful in QNC bioremediation and can be used as a bio-formulation for agro-economical and industrial application., (Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.)