1. Cognitive changes after methanol exposure: Longitudinal perspective.
- Author
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Bukacova K, Mana J, Klempíř J, Lišková I, Brožová H, Poláková K, Žák I, Pelclová D, Zakharov S, Růžička E, and Bezdicek O
- Subjects
- Adult, Aged, Cognitive Dysfunction chemically induced, Cognitive Dysfunction diagnosis, Cognitive Dysfunction epidemiology, Czech Republic epidemiology, Depression chemically induced, Depression diagnosis, Depression epidemiology, Female, Humans, Longitudinal Studies, Male, Memory Disorders chemically induced, Memory Disorders diagnosis, Memory Disorders epidemiology, Middle Aged, Neuropsychological Tests, Neurotoxicity Syndromes diagnosis, Neurotoxicity Syndromes epidemiology, Prevalence, Time Factors, Young Adult, Cognition drug effects, Cognitive Dysfunction psychology, Depression psychology, Memory Disorders psychology, Memory, Episodic, Methanol poisoning, Neurotoxicity Syndromes psychology
- Abstract
Background: From 2012 to 2013, there was a mass methanol poisoning outbreak in the Czech Republic. Methanol metabolites can cause specific lesions in the basal ganglia, subcortical white matter, and optic nerve. However, long-term sequelae of methanol poisoning on cognitive functioning have not yet been explored. The current study aimed to delineate the cognitive changes observed in methanol poisoning survivors in the seven years since 2012., Methods: We conducted longitudinal research with repeated measurements in 2013, 2015, 2017 and 2019 to evaluate the development of cognitive changes after acute methanol poisoning. A complex neuropsychological battery consisted of tests of global cognitive performance, auditory and visual attention, executive functioning, learning and memory, working memory and language. Motor performance measures and depression scale were also included., Results: Repeated measures ANOVA of four measurements with post-hoc tests showed a significant decline in the Mini-Mental State Examination (p = 0.007); however, other parameters were not significantly decreasing. In comparison to normative values, the z-scores for each test measure, in the memory domain, in particular, ranged from 43 to 60 % of participants below 1.5 SD. Mild to severe depression levels from the onset of poisoning improved during the seven years, returning to normal in up to 27 % of participants., Conclusion: In the longitudinal perspective, methanol poisoning survivors manifest progressive global cognitive decline and overall persistent below-average cognitive performance with some improvements in the frequency of depressive symptoms., Competing Interests: Declaration of Competing Interest The authors report no declarations of interest., (Copyright © 2021 Elsevier B.V. All rights reserved.)
- Published
- 2021
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