Search

Phosphoinositide-3 kinase (PI3K)-δ and PI3K-γ are preferentially expressed in immune cells, and inhibitors targeting these isoforms are hypothesized to have anti-inflammatory activity by affecting the adaptive and innate immune response. We report on a potent oral PI3K-δ and PI3K-γ inhibitor (IPI-145) and characterize this compound in biochemical, cellular, and in vivo assays. These studies demonstrate that IPI-145 exerts profound effects on adaptive and innate immunity by inhibiting B and T cell proliferation, blocking neutrophil migration, and inhibiting basophil activation. We explored the therapeutic value of combined PI3K-δ and PI3K-γ blockade, and IPI-145 showed potent activity in collagen-induced arthritis, ovalbumin-induced asthma, and systemic lupus erythematosus rodent models. These findings support the hypothesis that inhibition of immune function can be achieved through PI3K-δ and PI3K-γ blockade, potentially leading to significant therapeutic effects in multiple inflammatory, autoimmune, and hematologic diseases., (Copyright © 2013 Elsevier Ltd. All rights reserved.)

This discussion and the three case examples illustrate different etiologies of shoulder problems in the golfer. Age and the mechanics of an individual swing are factors to consider when defining the core problem. In summarizing shoulder pain in the golfer, perhaps the key point is that a thorough patient evaluation is essential to diagnose the problem accurately. It is only with a specific and accurate diagnosis that an optimal treatment program can be designed, and successful outcomes will be the result.

In summary, a sport-specific exercise program for golfers includes warming up, stretching, strengthening, and cardiovascular conditioning. The goals of such a program incorporated with playing the game of golf are to optimize performance and prevent injuries. The integration of each of these components represents a well-balanced fitness approach to sport and enhances the enjoyment of the game.