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Your search keyword '"Perdiguero E"' showing total 4 results
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4 results on '"Perdiguero E"'

1. Stem Cells and Aging

Author

Perdiguero, E., primary, García-Prat, L., additional, Sousa-Victor, P., additional, and Muñoz-Cánoves, P., additional

Published
2016
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2. Lymphomyeloid contribution of an immune-restricted progenitor emerging prior to definitive hematopoietic stem cells

Author

Böiers, C, Carrelha, J, Lutteropp, M, Luc, S, Green, J, Azzoni, E, Woll, P, Mead, A, Hultquist, A, Swiers, G, Perdiguero, E, Macaulay, I, Melchiori, L, Luis, T, Kharazi, S, Bouriez-Jones, T, Deng, Q, Pontén, A, Atkinson, D, Jensen, C, Sitnicka, E, Geissmann, F, Godin, I, Sandberg, R, de Bruijn, M, Jacobsen, S, Böiers, Charlotta, Carrelha, Joana, Lutteropp, Michael, Luc, Sidinh, Green, Joanna C A, Azzoni, Emanuele, Woll, Petter S, Mead, Adam J, Hultquist, Anne, Swiers, Gemma, Perdiguero, Elisa Gomez, Macaulay, Iain C, Melchiori, Luca, Luis, Tiago C, Kharazi, Shabnam, Bouriez-Jones, Tiphaine, Deng, Qiaolin, Pontén, Annica, Atkinson, Deborah, Jensen, Christina T, Sitnicka, Ewa, Geissmann, Frederic, Godin, Isabelle, Sandberg, Rickard, de Bruijn, Marella F T R, Jacobsen, Sten Eirik W, Böiers, C, Carrelha, J, Lutteropp, M, Luc, S, Green, J, Azzoni, E, Woll, P, Mead, A, Hultquist, A, Swiers, G, Perdiguero, E, Macaulay, I, Melchiori, L, Luis, T, Kharazi, S, Bouriez-Jones, T, Deng, Q, Pontén, A, Atkinson, D, Jensen, C, Sitnicka, E, Geissmann, F, Godin, I, Sandberg, R, de Bruijn, M, Jacobsen, S, Böiers, Charlotta, Carrelha, Joana, Lutteropp, Michael, Luc, Sidinh, Green, Joanna C A, Azzoni, Emanuele, Woll, Petter S, Mead, Adam J, Hultquist, Anne, Swiers, Gemma, Perdiguero, Elisa Gomez, Macaulay, Iain C, Melchiori, Luca, Luis, Tiago C, Kharazi, Shabnam, Bouriez-Jones, Tiphaine, Deng, Qiaolin, Pontén, Annica, Atkinson, Deborah, Jensen, Christina T, Sitnicka, Ewa, Geissmann, Frederic, Godin, Isabelle, Sandberg, Rickard, de Bruijn, Marella F T R, and Jacobsen, Sten Eirik W more...

Abstract

In jawed vertebrates, development of an adaptive immune-system is essential for protection of the born organism against otherwise life-threatening pathogens. Myeloid cells of the innate immune system are formed early in development, whereas lymphopoiesis has been suggested to initiate much later, following emergence of definitive hematopoietic stem cells (HSCs). Herein, we demonstrate that the embryonic lymphoid commitment process initiates earlier than previously appreciated, prior to emergence of definitive HSCs, through establishment of a previously unrecognized entirely immune-restricted and lymphoid-primed progenitor. Notably, this immune-restricted progenitor appears to first emerge in the yolk sac and contributes physiologically to the establishment of lymphoid and some myeloid components of the immune-system, establishing the lymphomyeloid lineage restriction process as an early and physiologically important lineage-commitment step in mammalian hematopoiesis more...

Published
2013

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3. Cellular and molecular mechanisms regulating fibrosis in skeletal muscle repair and disease.

Author

Serrano AL, Mann CJ, Vidal B, Ardite E, Perdiguero E, and Muñoz-Cánoves P

Subjects
Aging, Animals, Extracellular Matrix metabolism, Fibrosis metabolism, Humans, Muscle, Skeletal injuries, Muscle, Skeletal pathology, Muscular Dystrophies metabolism, Muscular Dystrophies pathology, Regeneration, Muscle, Skeletal physiology
Abstract

The repair of an injured tissue is a complex biological process involving the coordinated activities of tissue-resident and infiltrating cells in response to local and systemic signals. Following acute tissue injury, inflammatory cell infiltration and activation/proliferation of resident stem cells is the first line of defense to restore tissue homeostasis. However, in the setting of chronic tissue damage, such as in Duchenne Muscular Dystrophy, inflammatory infiltrates persist, the ability of stem cells (satellite cells) is blocked and fibrogenic cells are continuously activated, eventually leading to the conversion of muscle into nonfunctional fibrotic tissue. This review explores our current understanding of the cellular and molecular mechanisms underlying efficient muscle repair that are dysregulated in muscular dystrophy-associated fibrosis and in aging-related muscle dysfunction., (Copyright © 2011 Elsevier Inc. All rights reserved.) more...

Published
2011
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4. An acetyl-CoA synthetase not encoded by the facA gene is expressed under carbon starvation in Phycomyces blakesleeanus.

Author

De Cima S, Rúa J, Perdiguero E, del Valle P, Busto F, Baroja-Mazo A, and de Arriaga D

Subjects
Acetic Acid metabolism, Blotting, Northern, Coenzyme A Ligases genetics, Coenzyme A Ligases isolation & purification, Enzyme Stability, Hot Temperature, Kinetics, Propionates metabolism, RNA, Fungal analysis, RNA, Messenger analysis, Substrate Specificity, Temperature, Time Factors, Coenzyme A Ligases biosynthesis, Gene Expression Regulation, Fungal, Phycomyces enzymology
Abstract

Two forms of acetyl-CoA synthetase (ACS1 and ACS2) have been detected in Phycomyces blakesleeanus. ACS1, encoded by the gene facA, was induced by acetate and repressed by glucose at the transcriptional level. ACS2, not encoded by the gene facA, was detected as a response to carbon starvation both in the wild type and in an facA(-) mutant. Both enzymes were purified and characterized. They can use acetate and propionate as substrates. ACS2 is a much more stable enzyme than ACS1. After 60 min incubation at 55 degrees C, ACS2 retained 50% of its activity whereas ACS1 only retained 3%. The optimum temperature was 50 degrees C for ACS2 and 30 degrees C for ACS1. more...

Published
2005
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