1. Les inhibiteurs des points de contrôle immunitaire dans le cancer bronchique non à petites cellules de stade avancé.
- Author
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Fabre E, Pécuchet N, and Cadranel J
- Subjects
- Carcinoma, Non-Small-Cell Lung mortality, Carcinoma, Non-Small-Cell Lung pathology, Cell Cycle Checkpoints immunology, Clinical Trials as Topic, Docetaxel, Humans, Lung Neoplasms mortality, Lung Neoplasms pathology, Nivolumab, Programmed Cell Death 1 Receptor antagonists & inhibitors, Taxoids therapeutic use, Antibodies, Monoclonal therapeutic use, Antibodies, Monoclonal, Humanized therapeutic use, Antineoplastic Agents therapeutic use, Carcinoma, Non-Small-Cell Lung therapy, Cell Cycle Checkpoints drug effects, Immunotherapy methods, Lung Neoplasms therapy
- Abstract
IMMUNE CHECKPOINT INHIBITORS IN ADVANCED NON-SMALL CELL LUNG CANCER: T-cell-directed strategies represent currently a major advance in the treatment of advanced non-small-cell lung cancer, regarding their efficacy and tolerance. Nivolumab and pembrolizumab, two monoclonal antibodies targeting programmed cell death protein 1 (PD-1) have shown their efficacy in phase III studies. Several other drugs are developed and the benefit of association is being evaluated. In this article, we propose to summarize the clinical development of immune checkpoint inhibitors in patients with advanced non-small cell lung cancer., (© 2016 Société Française du Cancer. Publié par Elsevier Masson SAS. Tous droits réservés.)
- Published
- 2016
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