Search

Your search keyword '"Patravale, Vandana B."' showing total 11 results
Start Over Author "Patravale, Vandana B." Publisher elsevier
11 results on '"Patravale, Vandana B."'

2. Contributors

Author

Agrawal, Ankit A., primary, Bajpai, Aman, additional, Banerjee, Rinti, additional, Basu, Sudipta, additional, Ghegade, Vaibhav N., additional, Ghosh, Sougata, additional, Jajal, Dhara, additional, Kapse, Archana A., additional, Kelkar, Radhika K., additional, Keshari, Roshan, additional, Lohakare, Shruti, additional, Mhatre, Susmit, additional, Mostafavi, Ebrahim, additional, Nadar, Shamraja S., additional, Pandya, Anjali, additional, Patil, Neha P., additional, Patil, Pravin D., additional, Patil, Runali, additional, Patil, Sadhana P., additional, Patravale, Vandana B., additional, Pawar, Kaustubh A., additional, Phirke, Ajay N., additional, Pise, Pradnya V., additional, Pulakkat, Sreeranjini, additional, Rajput, Amarjitsing, additional, Sengupta, Poulomi, additional, Shah, Sejal, additional, Shinde, Sopan, additional, Srivastava, Tishya, additional, Thorat, Nanasaheb, additional, Tiwari, Manishkumar S., additional, Upadhaya, Prashant, additional, and Webster, Thomas J., additional

Published
2022
Full Text
View/download PDF

3. Nanobiomaterials for regenerative medicine

Author

Pandya, Anjali, primary, Upadhaya, Prashant, additional, Lohakare, Shruti, additional, Srivastava, Tishya, additional, Mhatre, Susmit, additional, Pulakkat, Sreeranjini, additional, and Patravale, Vandana B., additional

Published
2022
Full Text
View/download PDF

4. Liposome-loaded Polymeric Microneedles for Enhanced Skin Deposition of Rifampicin

Author

Universidad de Sevilla. Departamento de Farmacia y Tecnología Farmacéutica, Wellcome Trust, Anjani, Qonita Kurnia, Pandya, Anjali K., Demartis, Sara, Domínguez Robles, Juan, Moreno Castellanos, Natalia, Li, Huanhuan, Gavini, Elisabetta, Patravale, Vandana B., Donnelly, Ryan F., Universidad de Sevilla. Departamento de Farmacia y Tecnología Farmacéutica, Wellcome Trust, Anjani, Qonita Kurnia, Pandya, Anjali K., Demartis, Sara, Domínguez Robles, Juan, Moreno Castellanos, Natalia, Li, Huanhuan, Gavini, Elisabetta, Patravale, Vandana B., and Donnelly, Ryan F.

Abstract

Methicillin-resistant Staphylococcus aureus (MRSA) is a prevailing bacterial pathogen linked to superficial skin and soft tissue infections (SSTIs). Rifampicin (RIF), a potent antibiotic against systemic and localised staphylococcal infections, faces limitations due to its low solubility. This constraint hampers its therapeutic potential for MRSA-induced SSTIs. To address this, an advanced liposomal system was designed for efficient dermal RIF delivery. Rifampicin-loaded liposomes (LipoRIF) were embedded within polymeric dissolving microneedles (DMNs) to enable targeted intradermal drug delivery. A robust Design of Experiment (DoE) methodology guided the systematic preparation and optimisation of LipoRIF formulations. The optimal LipoRIF formulation integrated within polymeric DMNs. These LipoRIF-DMNs exhibited favourable mechanical properties and effective skin insertion characteristics. Notably, in vitro assays on skin deposition unveiled a transformative result – the DMN platform significantly enhanced LipoRIF deposition within the skin, surpassing LipoRIF dispersion alone. Moreover, LipoRIF-DMNs displayed minimal cytotoxicity toward cells. Encouragingly, rigorous in vitro antimicrobial evaluations demonstrated LipoRIF-DMNs' capacity to inhibit MRSA growth compared to the control group. LipoRIF-DMNs propose a potentially enhanced, minimally invasive approach to effectively manage SSTIs and superficial skin ailments stemming from MRSA infections.

Published
2023

6. Quantum Dots

Author

Pawar, Rohit S., primary, Upadhaya, Prashant G., additional, and Patravale, Vandana B., additional

Published
2018
Full Text
View/download PDF

8. List of Contributors

Author

Agrawal, Satish, primary, Ahmad, Hafsa, additional, Alovero, Fabiana, additional, Anton, Nicolas, additional, Arya, Abhishek, additional, Baghaban-Eslaminejad, Mohamadreza, additional, Bajpai, Anil Kumar, additional, Baskaran, R., additional, Bernuci, Marcelo P., additional, Bien, Karolina, additional, Bisen, Prakash S., additional, Bortolanza, Mariza, additional, Busignies, Virginie, additional, Celichowski, Grzegorz, additional, Charrueau, Christine, additional, Chauhan, Nagendra S., additional, Chouhan, Raje, additional, Díaz, Máximo P., additional, de Araújo, Daniele Ribeiro, additional, de Melo, Nathalie Ferreira Silva, additional, de Morais Ribeiro, Lígia Nunes, additional, de Paula, Eneida, additional, Del-Bel, Elaine, additional, Dixit, Meenal, additional, Dong, Yuan-Cai, additional, Dwivedi, Anil K., additional, Ermertcan, Aylin T., additional, Escriou, Virginie, additional, Eskiizmir, Görkem, additional, Figueiras, Ana, additional, Franz-Montan, Michelle, additional, Fukuchi, Kunihiko, additional, Fukuda, Toshiyuki, additional, Goswami, Shilpi, additional, Gothwal, Avinash, additional, Grobelny, Jaroslaw, additional, Gupta, Lokesh, additional, Gupta, Madhu, additional, Gupta, Umesh, additional, Gutierrez, Rosa Martha Perez, additional, Hawthorne, Gabriel H., additional, Huh, Kang Moo, additional, Issy, Ana C., additional, Jadhav, Indrani, additional, Jana, Sougata, additional, Jimenez-Kairuz, Alvaro F., additional, Kadwadkar, Namrata A., additional, Kamali, Amir, additional, Kanamoto, Taisei, additional, Karandikar, Sayali, additional, Khan, Iliyas, additional, Kharkar, Prachi B., additional, Khurshid, Zohaib, additional, Konur, Ozcan, additional, Kotohda, Kayoko, additional, Krzyzowska, Malgorzata, additional, Kulshreshtha, Niha M., additional, Kurbanoglu, Sevinc, additional, Lee, Yong-Kyu, additional, Letchmanan, Kumaran, additional, Maiti, Sabyasachi, additional, Manzo, Ruben H., additional, Martínez, Alejandro R., additional, Mendez, Juan Vicente Mendez, additional, Miranda Calderon, Jorge E., additional, Mirani, Amit, additional, Moshiri, Ali, additional, Muralidaran, Yuvashree, additional, Najeeb, Shariq, additional, Nakashima, Hideki, additional, Ng, Wai Kiong, additional, Nguyen, Thi Trinh Lan, additional, Noguez Méndez, Norma A., additional, Nurunnabi, Md, additional, Ohno, Hirokazu, additional, Oizumi, Takaaki, additional, Olivera, María E., additional, Orlowski, Piotr, additional, Oryan, Ahmad, additional, Ozkan, Sibel A., additional, Padma, V. Vijaya, additional, Palomec, Xochitl C., additional, Patankar, Sandeep, additional, Patravale, Vandana B., additional, Priya, L. Bharathi, additional, Quirino Barreda, Carlos T., additional, Ragavan, Gokulakannan, additional, Ramírez-Rigo, María V., additional, Ranoszek-Soliwoda, Katarzyna, additional, Rehman, Ihtesham Ur, additional, Revuri, Vishnu, additional, Ribeiro, Andreza Maria, additional, Sakagami, Hiroshi, additional, Shah, Mohsin, additional, Sharma, Ashok K., additional, Sharma, Vikas, additional, Shen, Shou-Cang, additional, Sheng, Hong, additional, Shrivastava, Divya, additional, Singh, Anurag K., additional, Sinha, Nehi, additional, Talkar, Swapnil S., additional, Tchoreloff, Pierre, additional, Terakubo, Shigemi, additional, Tomaszewska, Emilia, additional, Urioste, César G., additional, Uslu, Bengi, additional, Vandamme, Thierry F., additional, Vazquez, Israel Arzate, additional, Vega, Abraham F., additional, Veiga, Francisco, additional, Viswanathan, Pragasam, additional, Waybhase, Vishal, additional, Xie, Jingqi, additional, Xu, Ruian, additional, Yamamoto, Masaji, additional, Yapici, Kerim, additional, Yasui, Toshikazu, additional, Yoon, Sung C., additional, Yoshida, Hidenobu, additional, Zafar, Muhammad S., additional, and Zohaib, Sana, additional

Published
2017
Full Text
View/download PDF

10. Starch microsponges for enhanced retention and efficacy of topical sunscreen.

Author

Bhuptani RS and Patravale VB

Subjects
Calorimetry, Differential Scanning methods, Drug Delivery Systems methods, Humans, Porosity, X-Ray Diffraction methods, Skin drug effects, Skin Absorption drug effects, Starch chemistry, Sunscreening Agents chemistry, Sunscreening Agents pharmacology
Abstract

Topical sunscreen products are universally applied by numerous individuals to protect their skin from the detrimental effects of UV radiation. However, lately, studies have revealed the risks associated with percutaneous absorption of UV filters leading to undesirable systemic side effects such as hormonal disturbances and allergies. In this study, an innovative sunscreen formulation was developed based on starch microsponges as a key carrier encapsulating an organic sunscreen benzophenone‑3. The developed starch microsponges were characterized by scanning electron microscopy and nitrogen adsorption/desorption analysis. The results showed that starch microsponges possessed a high BET surface area (85.45 m 2 /g) with spherical porous morphology with pore size <200 nm. Benzophenone‑3 was loaded into the starch microsponges by immersion/solvent evaporation and benzophenone‑3 loaded starch microsponges were characterized by scanning electron microscopy, differential scanning calorimetry, powder X-ray diffraction, Fourier transform infrared spectroscopy, and nitrogen adsorption-desorption measurements. Results corroborated that benzophenone‑3 was successfully entrapped within the nanopores of starch microsponges. A starch microsponge based sunscreen cream was formulated, characterized and clinically tested. Rheological, texture and sensorial assessment showed that starch microsponges based sunscreen product showed good spreadability, non-sticky, rich texture favorable for consumer usage. In vitro and ex-vivo studies demonstrated benzophenone‑3 loaded starch microsponges gave improved photoprotection, higher SPF and reduced cutaneous penetration compared to raw benzophenone‑3 cream. Clinically, patch study confirmed that the developed starch microsponges based sunscreen cream was skin safe and biocompatible. Thus, the amalgamation of sunscreen molecule benzophenone‑3 into starch microsponges produced a safe, effective innovative sunscreen product., (Copyright © 2019 Elsevier B.V. All rights reserved.)

Published
2019
Full Text
View/download PDF

11. Curcumin Cocrystal Micelles-Multifunctional Nanocomposites for Management of Neurodegenerative Ailments.

Author

Desai PP and Patravale VB

Subjects
Antioxidants chemistry, Antioxidants pharmacology, Biological Availability, Brain drug effects, Calorimetry, Differential Scanning methods, Cell Line, Tumor, Crystallization methods, Drug Carriers chemistry, Humans, Micelles, Solubility drug effects, Spectroscopy, Fourier Transform Infrared methods, X-Ray Diffraction methods, Alzheimer Disease drug therapy, Curcumin chemistry, Curcumin pharmacology, Nanocomposites chemistry
Abstract

Curcumin, a potent antioxidant polyphenol with neuroprotective and antiamyloid activities, has significant potential in the treatment of neurodegenerative disorders such as Alzheimer's disease. However, its clinical translation is delayed due to poor bioavailability. For effective use of curcumin in Alzheimer's disease, it is imperative to increase its bioavailability with enhanced delivery at a therapeutic site that is, brain. With this objective, pharmaceutical cocrystals of curcumin were developed and incorporated in micellar nanocarriers for nose-to-brain delivery. For cocrystals, an antioxidant hydrophilic coformer was strategically selected using molecular modeling approach. The cocrystals were formulated using a planetary ball mill, and the process was optimized using 3 2 factorial design followed by characterization using differential scanning calorimetry, X-ray diffraction, and Fourier-transform infrared spectroscopy analysis. The cocrystal micelles exhibited globule size of 28.79 ± 0.86 nm. Further, curcumin cocrystal and co-crystal micelles exhibited a significantly low (p value <0.01) IC 50 concentration for antioxidant activity as compared to curcumin corroborating superior antioxidant performance. In vivo studies revealed about 1.7-fold absolute bioavailability of curcumin cocrystal micelles with C max of 1218.38 ± 58.11 ng/mL and showed significantly high brain distribution even beyond 6 hours of dosing. Thus, the studies confirmed enhanced bioavailability, higher brain uptake, retention, and delayed clearance with curcumin cocrystal micellar nanocarriers., (Copyright © 2018 American Pharmacists Association®. Published by Elsevier Inc. All rights reserved.)

Published
2018
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results