372 results on '"Park, Seung"'
Search Results
2. Contributors
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Adamski, Jill, primary, Agaronov, Maksim, additional, Alden, Beth M., additional, Arinsburg, Suzanne, additional, Bloch, Evan M., additional, Brown, Michelle R., additional, Bucy, R. Pat, additional, Chaffin, D. Joe, additional, Chhibber, Vishesh, additional, Crane, Jason E., additional, Dallas, Karen, additional, DePalma, Helene, additional, Fadeyi, Emmanuel A., additional, Francis, Richard O., additional, Fritsma, George A., additional, Gautreaux, Michael D., additional, Gehrie, Eric A., additional, Hartenstine, Javi L., additional, Hayes, Chelsea, additional, Hendrickson, Jeanne E., additional, Hsu, Yen-Michael S., additional, Ipe, Tina S., additional, Jacquot, Cyril, additional, Jhang, Jeffrey S., additional, Johnson, Susan T., additional, Kaplan, Alesia, additional, Kinard, Theresa, additional, Lorenz, Robin G., additional, Marques, Marisa B., additional, Mason, Holli M., additional, Morgan, Shanna, additional, Nester, Theresa A., additional, Pagano, Monica B., additional, Papari, Mona, additional, Park, Seung, additional, Pham, Huy P., additional, Raciti, Patricia M., additional, Ratkal, Swati, additional, Reich-Slotky, Ronit, additional, Schlueter, Annette J., additional, Schmitz, John, additional, Schwartz, Joseph, additional, Shaikh, Salima, additional, Shaz, Beth H., additional, Siniard, Rance C., additional, Slayten, Jayanna Kay, additional, Tormey, Christopher A., additional, Virk, Mrigender, additional, Williams,, Lance A., additional, Wong, Edward C.C., additional, Wu, YanYun, additional, and Zheng, X. Long, additional
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- 2018
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3. Normal Values of Aortic Root Size According to Age, Sex, and Race: Results of the World Alliance of Societies of Echocardiography Study
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Patel, H, Miyoshi, T, Addetia, K, Citro, R, Daimon, M, Gutierrez Fajardo, P, Kasliwal, R, Kirkpatrick, J, Monaghan, M, Muraru, D, Ogunyankin, K, Park, S, Ronderos, R, Sadeghpour, A, Scalia, G, Takeuchi, M, Tsang, W, Tucay, E, Tude Rodrigues, A, Amuthan, V, Zhang, Y, Schreckenberg, M, Blankenhagen, M, Degel, M, Hitschrich, N, Mor-Avi, V, Asch, F, Lang, R, Patel, Hena N, Miyoshi, Tatsuya, Addetia, Karima, Citro, Rodolfo, Daimon, Masao, Gutierrez Fajardo, Pedro, Kasliwal, Ravi R, Kirkpatrick, James N, Monaghan, Mark J, Muraru, Denisa, Ogunyankin, Kofo O, Park, Seung Woo, Ronderos, Ricardo E, Sadeghpour, Anita, Scalia, Gregory M, Takeuchi, Masaaki, Tsang, Wendy, Tucay, Edwin S, Tude Rodrigues, Ana Clara, Amuthan, Vivekanandan, Zhang, Yun, Schreckenberg, Marcus, Blankenhagen, Michael, Degel, Markus, Hitschrich, Niklas, Mor-Avi, Victor, Asch, Federico M, Lang, Roberto M, Patel, H, Miyoshi, T, Addetia, K, Citro, R, Daimon, M, Gutierrez Fajardo, P, Kasliwal, R, Kirkpatrick, J, Monaghan, M, Muraru, D, Ogunyankin, K, Park, S, Ronderos, R, Sadeghpour, A, Scalia, G, Takeuchi, M, Tsang, W, Tucay, E, Tude Rodrigues, A, Amuthan, V, Zhang, Y, Schreckenberg, M, Blankenhagen, M, Degel, M, Hitschrich, N, Mor-Avi, V, Asch, F, Lang, R, Patel, Hena N, Miyoshi, Tatsuya, Addetia, Karima, Citro, Rodolfo, Daimon, Masao, Gutierrez Fajardo, Pedro, Kasliwal, Ravi R, Kirkpatrick, James N, Monaghan, Mark J, Muraru, Denisa, Ogunyankin, Kofo O, Park, Seung Woo, Ronderos, Ricardo E, Sadeghpour, Anita, Scalia, Gregory M, Takeuchi, Masaaki, Tsang, Wendy, Tucay, Edwin S, Tude Rodrigues, Ana Clara, Amuthan, Vivekanandan, Zhang, Yun, Schreckenberg, Marcus, Blankenhagen, Michael, Degel, Markus, Hitschrich, Niklas, Mor-Avi, Victor, Asch, Federico M, and Lang, Roberto M
- Abstract
Background: Accurate measurements of the aortic annulus and root are important for guiding therapeutic decisions regarding the need for aortic surgery. Current echocardiographic guidelines for identification of aortic root dilatation are limited because current normative values were derived predominantly from white individuals in narrow age ranges, and based partially on M-mode measurements. Using data from the World Alliance Societies of Echocardiography study, the authors sought to establish normal ranges of aortic dimensions across sexes, races, and a wide range of ages. Methods: Adult individuals free of heart, lung, and kidney disease were prospectively enrolled from 15 countries, with even distributions among sexes and age groups: young (18–40 years), middle aged (41–65 years) and old (>65 years). Transthoracic two-dimensional echocardiograms of 1,585 subjects (mean age, 47 ± 17 years; 50.4% men; mean body surface area [BSA], 1.77 ± 0.22 m2) were analyzed in a core laboratory following American Society of Echocardiography guidelines. Measurements, indexed separately by BSA and by height, included the aortic annulus, sinuses of Valsalva, and sinotubular junction. Differences among age, sex, and racial groups were evaluated using unpaired two-tailed Student's t tests. Results: All aortic root dimensions were larger in men compared with women. After indexing to BSA, all measured dimensions were significantly larger in women, whereas men continued to show larger dimensions after indexing to height. Of note, the upper limits of normal for all aortic dimensions were lower across all age groups, compared with the guidelines. Aortic dimensions were larger in older age groups in both sexes, a trend that persisted regardless of BSA or height adjustment. Last, differences in aortic dimensions were also observed according to race: Asians had the smallest nonindexed aortic dimensions at all levels. Conclusions: There are significant differences in aortic dimensions acco
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- 2022
4. List of Contributors
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Abdelbaset-Ismail, Ahmed, primary, Allickson, Julie, additional, Alshomer, Feras, additional, Ali AlWahab, Noaf Salah, additional, Atala, Antony, additional, Baume, Alexander, additional, Boularaoui, Selwa Mokhtar, additional, Christoforou, Nicolas, additional, Gomes, Manuela E., additional, Gonçalves, Ana I., additional, Hong, Hyun Sook, additional, Jackson, John D., additional, Joyner, Katherine A., additional, Kalaskar, Deepak M., additional, Kim, Ji Hyun, additional, Kim, Moon Suk, additional, Kim, Na Jung, additional, Kim, Suna, additional, Ko, In Kap, additional, Lambert, Byron, additional, Lee, Bo Keun, additional, Lee, Chang H., additional, Lee, Sang Jin, additional, Li, Yuqi, additional, Lu, Baisong, additional, Nair, Ashwin, additional, Ogawa, Rei, additional, Ott, Harald C., additional, Park, Seung Hun, additional, Payne, Richard, additional, Rajab, T. Konrad, additional, Rapoza, Richard, additional, Ratajczak, Mariusz Z., additional, Reis, Rui L., additional, Rodrigues, Márcia T., additional, Shapiro, Lindsey E., additional, Sheehy, Alexander, additional, Son, Youngsook, additional, Stains, Joseph P., additional, Sun, Zhaoli, additional, Tang, Liping, additional, Taraban, Marc B., additional, Tarafder, Solaiman, additional, Meng Teo, Jeremy Choon, additional, Wang, Hung-Jen, additional, Williams, George M., additional, Yoo, James J., additional, Yu, Yihua B., additional, and Zhang, Nan, additional
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- 2016
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5. Biomarkers in HCV Infection
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Park, Seung Ha, primary, Bang, Chang Seok, additional, and Kim, Dong Joon, additional
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- 2015
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6. Contributors
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Akasaka, Takashi, primary, Akin, Ibrahim, additional, Alegria, Jorge R., additional, Almonacid, Alexandra, additional, Alviar, Carlos L., additional, Angiollilo, Dominick J., additional, Ansel, Gary M., additional, Anwaruddin, Saif, additional, Balzer, David T., additional, Bannan, Amr T., additional, Barsness, Gregory W., additional, Beekman, Robert H., additional, Beygui, Farzin, additional, Bittl, John A., additional, Bonhoeffer, Philipp, additional, Braendle, Michael, additional, Brennan, J. Matthew, additional, Brindis, Ralph, additional, Brochet, Eric, additional, Burke, David, additional, Büttner, Heinz Joachim, additional, Byrne, Robert, additional, Cannon, Christopher P., additional, Casserly, Ivan P., additional, Chacko, Matthews, additional, Chew, Derek P., additional, Cho, Leslie, additional, Coats, Louise, additional, Colombo, Antonio, additional, Costa, Marco A., additional, Cribier, Alain, additional, Croce, Kevin J., additional, Cura, Fernando, additional, Dehmer, Gregory J., additional, Dieter, Robert S., additional, Douglas, John S., additional, Eltchaninoff, Helene, additional, Eng, Marvin H., additional, Fitzgerald, Peter J., additional, Fuster, Valentin, additional, Garcia, Mario J., additional, Garg, Scot, additional, Goldstein, Jeffrey, additional, Goswani, Nilesh J., additional, Gray, William A., additional, Guagliumi, Giulio, additional, Hara, Hidehiko, additional, Hasan, Rani, additional, Henry, Timothy D., additional, Herrmann, Howard C., additional, Himbert, Dominique, additional, Hirsch, Russel, additional, Holmes, David R., additional, Honda, Yasuhiro, additional, Ince, Hüseyin, additional, Iung, Bernard, additional, Jneid, Hani, additional, Johnston, Samuel L., additional, Jollis, James G., additional, Kandzari, David, additional, Kapadia, Samir R., additional, Kastrati, Adnan, additional, Kereiakes, Dean J., additional, Kern, Morton J., additional, Khattab, Ahmed A., additional, Kim, Young-Hak, additional, Kirtane, Ajay J., additional, Kolluri, Raghu, additional, Krishnaswamy, Amar, additional, Kubo, Takashi, additional, Laham, Roger, additional, Lasala, John, additional, Lim, Michael J., additional, Lloyd, Thomas R., additional, Mark, Daniel, additional, Meier, Bernhard, additional, Montalescot, Gilles, additional, Moreno, Pedro R., additional, Moses, Jeffrey W., additional, Motiei, Arashk, additional, Mukherjee, Debabrata, additional, Naidu, Srihari S., additional, Nallamothu, Brahmajee K., additional, Narins, Craig R., additional, Ndrepepa, Gjin, additional, Neumann, Franz-Josef, additional, Nienaber, Christoph A., additional, Nobuyoshi, Masakiyo, additional, Palacios, Igor, additional, Park, Seung-Jung, additional, Patel, Uptal D., additional, Penn, Marc S., additional, Popma, Jeffrey, additional, Price, Matthew J., additional, Rajagopal, Vivek, additional, Ray, Kausik K., additional, Reiss, G. Russell, additional, Rocha-Singh, Krishna, additional, Roffi, Marco, additional, Rogers, R. Kevin, additional, Sanz, Javier, additional, Scheller, Bruno, additional, Schömig, Albert, additional, Schwartz, Robert S., additional, Serruys, Patrick, additional, Shirai, Shinichi, additional, Shishehbor, Mehdi H., additional, Silver, Mitchell J., additional, Simon, Daniel I., additional, Sirbu, Vasile, additional, Stankovic, Goran, additional, Stinis, Curtiss, additional, Stone, Gregg W., additional, Theodos, Gus, additional, Topaz, On, additional, Tron, Christophe, additional, Vahanian, Alec, additional, Van Tassel, Robert A., additional, White, Christopher J., additional, Williams, Matthew R., additional, Yock, Paul, additional, Yokoi, Hiroyoshi, additional, Zajarias, Alan, additional, Ziada, Khaled, additional, Ziskind, Andrew A., additional, and Zussman, Matthew, additional
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- 2012
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7. Percutaneous Coronary Intervention for Unprotected Left Main Coronary Artery Stenosis
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Park, Seung-Jung, primary and Kim, Young-Hak, additional
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- 2012
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8. Percutaneous coronary intervention in left main stem disease
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PARK, SEUNG-JUNG, primary and KIM, YOUNG-HAK, additional
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- 2008
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9. Graph-theoretic approach to optimal synthesis of supply networks: Distribution of gasoline from a refinery
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Kim, Young, primary, Fan, L.T., additional, Yun, Choamun, additional, Park, Seung Bin, additional, Park, Sunwon, additional, Bertok, Botond, additional, and Friedler, Ferenc, additional
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- 2008
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10. Contributors
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Brener, Sorin, primary, Caplin, John, additional, Christofferson, Ryan D., additional, Columbo, Antonio, additional, Cotton, James, additional, Cribier, Alain, additional, Cusack, Michael, additional, de Belder, Adam, additional, de Belder, Mark Andrew, additional, Duffy, Brendan, additional, Ettles, Duncan, additional, Falluji, Nezar M., additional, Galla, John M., additional, Gershlick, Anthony, additional, Grech, Ever, additional, Hall, Roger V., additional, Herath, Jagath, additional, Heuser, Richard R, additional, Hildick-Smith, David, additional, Holmes, David R., additional, Iakovou, Ioannis, additional, Kapadia, Samir R., additional, Karha, Juhana, additional, Khan, Sadia, additional, Khogali, Saib, additional, Kim, Young-Hak, additional, Kuchulakanti, Pramod, additional, Kunadian, Babu, additional, Lever, Harry M., additional, Lincoff, A. Michael, additional, Lo, Ted, additional, Lovell, Matthew, additional, Malik, Iqbal, additional, Mathur, Anthony, additional, Meier, Bernhard, additional, Moliterno, David J., additional, Moore, Roger KG, additional, Nicholson, Tony, additional, Nolan, James, additional, Norell, Michael S., additional, Ong, Andrew T.L., additional, Park, Seung-Jung, additional, Perrins, John, additional, Perry, Raphael A., additional, Potluri, Srinivasa P., additional, Prendergast, Bernard, additional, Qureshi, Shakeel Ahmed, additional, Ramee, Stephen, additional, Ramsdale, David R., additional, Schofield, Peter, additional, Sebastian, Arun, additional, Seidel, Amy L., additional, Serruys, Patrick W., additional, Shaia, Norman, additional, Shiu, Man Fai, additional, Smith, David, additional, Sorajja, Paul, additional, Stables, Rod, additional, Starkey, Ian R., additional, Thomas, Martyn, additional, Thomson, John, additional, Tuzcuu, Murat, additional, Uren, Neal, additional, Vahanian, Alec, additional, Vaina, Sophia, additional, Waksman, Ron, additional, Whitlow, Patrick L., additional, Windecker, Stephan, additional, and Zaman, Azfar G., additional
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- 2008
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11. Characterization of Kras‐Mediated Pancreatic Tumorigenesis in Zebrafish
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Davison, Jon M., primary, Woo Park, Seung, additional, Rhee, Jerry M., additional, and Leach, Steven D., additional
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- 2008
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12. Colitis, Ulcerative (Pediatric)
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Park, Seung-Dae, primary and Markowitz, James F., additional
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- 2004
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13. Efficacy and Safety of Stents in ST-Segment Elevation Myocardial Infarction
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Biosensors International, HeartFlow, Abbott Laboratories, Philips, Johnson & Johnson Services, Stentys, Medtronic, Terumo, Boston Scientific Corporation, Hexacath, General Electric, ASML, Biotronik, Sanofi, Regeneron Pharmaceuticals, Amgen, AstraZeneca, CSL Behring, Vifor Pharma, Amaranth, Valfix, TherOx, Reva Health, Robocath, Ablative Solutions, Matrizyme Pharma, Miracor, Neovasc, V-wave, Abiomed, Sirtex, Qool Therapeutics, SpectraWave, Cagent Vascular, Biostar, MedFocus, Bristol-Myers Squibb, Bayer, Sinomed, Cardialysis, Sino Medical Sciences Technology, Europa Digital & Publishing, Svelte Medical, Qualimed, Xeltis, Chichareon, Ply, Modolo, Rodrigo, Collet, Carlos, Tenekecioglu, Erhan, Vink, Maarten A., Oh, Pyung Chun, Ahn, Jung-Min, Musto, Carmine, Díaz de la Llera, Luis S., Cho, Young-Seok, Violini, Roberto, Park, Seung-Jung, Suryapranata, Harry, Piek, Jan J., de Winter, Robbert J., Wykrzykowska, Joanna J., Spaulding, Christian, Kang, Woong Chol, Slagboom, Ton, Hofma, Sjoerd H., Wijnbergen, Inge F., Di Lorenzo, Emilio, Pijls, Nico H., Räber, Lorenz, Brugaletta, Salvatore, Sabaté, Manel, Stoll, Hans-Peter, Stone, Gregg W., Windecker, Stephan, Onuma, Yoshinobu, Serruys, Patrick W., Biosensors International, HeartFlow, Abbott Laboratories, Philips, Johnson & Johnson Services, Stentys, Medtronic, Terumo, Boston Scientific Corporation, Hexacath, General Electric, ASML, Biotronik, Sanofi, Regeneron Pharmaceuticals, Amgen, AstraZeneca, CSL Behring, Vifor Pharma, Amaranth, Valfix, TherOx, Reva Health, Robocath, Ablative Solutions, Matrizyme Pharma, Miracor, Neovasc, V-wave, Abiomed, Sirtex, Qool Therapeutics, SpectraWave, Cagent Vascular, Biostar, MedFocus, Bristol-Myers Squibb, Bayer, Sinomed, Cardialysis, Sino Medical Sciences Technology, Europa Digital & Publishing, Svelte Medical, Qualimed, Xeltis, Chichareon, Ply, Modolo, Rodrigo, Collet, Carlos, Tenekecioglu, Erhan, Vink, Maarten A., Oh, Pyung Chun, Ahn, Jung-Min, Musto, Carmine, Díaz de la Llera, Luis S., Cho, Young-Seok, Violini, Roberto, Park, Seung-Jung, Suryapranata, Harry, Piek, Jan J., de Winter, Robbert J., Wykrzykowska, Joanna J., Spaulding, Christian, Kang, Woong Chol, Slagboom, Ton, Hofma, Sjoerd H., Wijnbergen, Inge F., Di Lorenzo, Emilio, Pijls, Nico H., Räber, Lorenz, Brugaletta, Salvatore, Sabaté, Manel, Stoll, Hans-Peter, Stone, Gregg W., Windecker, Stephan, Onuma, Yoshinobu, and Serruys, Patrick W.
- Abstract
[Background] To date, no specific drug-eluting stent (DES) has fully proven its superiority over others in patients with ST-segment elevation myocardial infarction (STEMI) undergoing percutaneous coronary intervention., [Objectives] The purpose of this study was to compare the safety and efficacy of coronary artery stents in STEMI patients in a patient-level network meta-analysis. [Methods] Eligible studies were dedicated randomized controlled trials comparing different stents in STEMI patients undergoing percutaneous coronary intervention with at least 12 months of clinical follow-up. Of 19 studies identified from the published data, individual patient data were collected in 15 studies with 10,979 patients representing 87.7% of patients in the overall network of evidence. The primary endpoint was the composite of cardiac death, reinfarction, or target lesion revascularization. [Results] Overall, 8,487 (77.3%) of 10,979 STEMI patients were male and the mean age was 60.7 years. At a median follow-up of 3 years, compared with bare-metal stents (BMS), patients treated with paclitaxel-, sirolimus-, everolimus-, or biolimus-eluting stents had a significantly lower risk of the primary endpoint (adjusted hazard ratios [HRs]: 0.74 [95% confidence interval (CI): 0.63 to 0.88], 0.65 [95% CI: 0.49 to 0.85], 0.70 [95% CI: 0.53 to 0.91], and 0.66 [95% CI: 0.49 to 0.88], respectively). The risk of primary endpoint was not different between patients treated with BMS and zotarolimus-eluting stents (adjusted HR: 0.83 [95% CI: 0.51 to 1.38]). Among patients treated with DES, no significant difference in the risk of the primary outcome was demonstrated. Treatment with second-generation DES was associated with significantly lower risk of definite or probable stent thrombosis compared with BMS (adjusted HR: 0.61 [95% CI: 0.42 to 0.89]) and first-generation DES (adjusted HR: 0.56 [95% CI: 0.36 to 0.88]). [Conclusions] In STEMI patients, DES were superior to BMS with respect to long-term efficacy. No difference in long-term efficacy and safety was observed among specific DES. Second-generation were superior to first-generation DES in reducing stent thrombosis. (Clinical Outcomes After Primary Percutaneou
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- 2019
14. Optimum design of linear induction motor for subway by neural network and SUMT
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Im, Dal–Ho, primary and Park, Seung–Chan, additional
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- 1995
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15. Early detection of cardiac involvement in Miyoshi myopathy: 2D strain echocardiography and late gadolinium enhancement cardiovascular magnetic resonance
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Kim Byoung, Park Seung, Lee Sang-Chol, Choi Jin-Oh, Chang Sung-A, Ryu Dong, Choe Yeon, Park Sung-Ji, Choi E, Kim Duk-Kyung, and Oh Jae K
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Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Abstract Background Miyoshi myopathy (MM) is an autosomal recessive distal myopathy characterized by early adult onset. Cardiomyopathy is a major clinical manifestation in other muscular dystrophies and an important prognostic factor. Although dysferlin is highly expressed in cardiac muscle, the effect of dysferlin deficiency in cardiac muscle has not been studied. We hypothesized that early myocardial dysfunction could be detected by 2D strain echocardiography and late gadolinium enhancement (LGE) cardiovascular magnetic resonance (CMR). Method Five consecutive MM patients (3 male) in whom we detected the DYSF gene mutation and age-matched healthy control subjects were included. None of the patients had history of cardiac disease or signs and symptoms of overt heart failure. Patients were studied using 2D strain echocardiography and CMR, with 2D strain being obtained using the Automated Function Imaging technique. Results All patients had preserved left ventricular systolic function. However, segmental Peak Systolic Longitudinal Strain (PSLS) was decreased in 3 patients. Global PSLS was significantly lower in patients with MM than in control subjects (p = 0.005). Basal anterior septum, basal inferior septum, mid anterior, and mid inferior septum PSLS were significantly lower in patients with MM than in control subjects (P < 0.0001, < 0.0001, 0.038 and 0.003, respectively). Four patients showed fibrosis by LGE. The reduced PSLS lesion detected by 2D strain tended to be in the same area as that which showed fibrosis by LGE. Conclusions Patients with MM showed subclinical involvement of the heart. 2D strain and LGE are sensitive methods for detecting myocardial dysfunction prior to the development of cardiovascular symptoms. The prognostic significance of these findings warrants further longitudinal follow-up.
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- 2010
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16. Clinical Significance of Lipid-Rich Plaque Detected by Optical Coherence Tomography: A 4-Year Follow-Up Study
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Xing, Lei, Higuma, Takumi, Wang, Zhao, Aguirre, Aaron D, Mizuno, Kyoichi, Takano, Masamichi, Dauerman, Harold L, Park, Seung-Jung, Jang, Yangsoo, Kim, Chong-Jin, Kim, Soo-Joong, Choi, So-Yeon, Itoh, Tomonori, Uemura, Shiro, Lowe, Harry, Walters, Darren L, Barlis, Peter, Lee, Stephen, Lerman, Amir, Toma, Catalin, Tan, Jack Wei Chieh, Yamamoto, Erika, Bryniarski, Krzysztof, Dai, Jiannan, Zanchin, Thomas, Zhang, Shaosong, Yu, Bo, Lee, Hang, Fujimoto, James, Fuster, Valentin, and Jang, Ik-Kyung
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lipids (amino acids, peptides, and proteins) ,cardiovascular diseases - Abstract
BACKGROUND Lipid-rich plaque (LRP) is thought to be a precursor to cardiac events. However, its clinical significance in coronary arteries has never been systematically investigated. OBJECTIVES This study investigated the prevalence and clinical significance of LRP in the nonculprit region of the target vessel in patients undergoing percutaneous coronary intervention (PCI). METHODS The study included 1,474 patients from 20 sites across 6 countries undergoing PCI, who had optical coherence tomography (OCT) imaging of the target vessel. Major adverse cardiac events (MACE) were defined as a composite of cardiac death, acute myocardial infarction, and ischemia-driven revascularization. Patients were followed for up to 4 years (median of 2 years). RESULTS Lipid-rich plaque was detected in nonculprit regions of the target vessel in 33.6% of patients. The cumulative rate of nonculprit lesion-related MACE (NC-MACE) over 48 months in patients with LRP was higher than in those without LRP (7.2% vs. 2.6%, respectively; p = 0.033). Acute coronary syndrome at index presentation (risk ratio: 2.538; 95% confidence interval [CI]: 1.246 to 5.173; p = 0.010), interruption of statin use ≥1 year (risk ratio: 4.517; 95% CI: 1.923 to 10.610; p = 0.001), and LRP in nonculprit regions (risk ratio: 2.061; 95% CI: 1.050 to 4.044; p = 0.036) were independently associated with increased NC-MACE. Optical coherence tomography findings revealed that LRP in patients with NC-MACE had longer lipid lengths (p < 0.001), wider maximal lipid arcs (p = 0.023), and smaller minimal lumen areas (p = 0.003) than LRPs in patients without MACE. CONCLUSIONS Presence of LRP in the nonculprit regions of the target vessel by OCT predicts increased risk for future NC-MACE, which is primarily driven by revascularization for recurrent ischemia. Lipid-rich plaque with longer lipid length, wider lipid arc, and higher degree of stenosis identified patients at higher risk of future cardiac events. (The Massachusetts General Hospital Optical Coherence Tomography Registry; NCT01110538).
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- 2017
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17. ACTION, REFLECTIVE POSSIBILITY, AND THE FRAME PROBLEM
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Brown, Frank M., primary and Park, Seung S., additional
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- 1987
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18. DOUBTING THOMAS: ACTION AND BELIEF REVISION
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Park, Seung S., primary
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- 1987
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19. DURABILITY AND ENGINEERING PROPERTIES OF SUPERPLASTICIZED CONCRETE
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Park, Seung Bum, primary and Go, Youn Seock, additional
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- 1987
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20. Unprotected left main coronary stenting: current status and future perspective
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Park, Seung-Jung
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- 1998
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21. Immediate and long-term follow-up results of the cordis stent
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Park, Seung-Jung, Park, Seong-Wook, Hong, Myeong-Ki, Cheung, Sang-Sig, Kim, Jae-Jeong, and Lee, Cheol-Whan
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- 1997
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22. Continuum of vasodilator stress from rest to contrast medium to adenosine hyperemia for fractional flow reserve assessment
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Keith G. Oldroyd, Sérgio Bravo Baptista, Nico H.J. Pijls, Frederik M. Zimmermann, Barry Hennigan, Gilles Rioufol, Hyoung-Mo Yang, Julien Adjedj, Mitsuaki Matsumura, Bon-Kwon Koo, Seung-Jung Park, Emanuele Barbato, Giovanni Esposito, Nils P. Johnson, Akiko Maehara, Antonio Maria Leone, William F. Fearon, Richard L. Kirkeeide, Bruno Trimarco, Nils Witt, Bernard De Bruyne, Colin Berry, Allen Jeremias, K. Lance Gould, George S. Chrysant, Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN), Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National de la Recherche Agronomique (INRA), Cardiovascular Biomechanics, Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hospices Civils de Lyon (HCL), Johnson, Nils P, Jeremias, Allen, Zimmermann, Frederik M, Adjedj, Julien, Witt, Nil, Hennigan, Barry, Koo, Bon Kwon, Maehara, Akiko, Matsumura, Mitsuaki, Barbato, Emanuele, Esposito, Giovanni, Trimarco, Bruno, Rioufol, Gille, Park, Seung Jung, Yang, Hyoung Mo, Baptista, Sérgio B, Chrysant, George S, Leone, Antonio M, Berry, Colin, De Bruyne, Bernard, Gould, K. Lance, Kirkeeide, Richard L, Oldroyd, Keith G, Pijls, Nico H. J, and Fearon, William F.
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Male ,Cardiac Catheterization ,Time Factors ,medicine.medical_treatment ,Vasodilator Agents ,[SDV]Life Sciences [q-bio] ,Contrast Media ,Fractional flow reserve ,Coronary Artery Disease ,030204 cardiovascular system & hematology ,Coronary artery disease ,0302 clinical medicine ,030212 general & internal medicine ,Prospective Studies ,fractional flow reserve ,Cardiac catheterization ,Vasodilators ,Middle Aged ,Coronary Vessels ,3. Good health ,Fractional Flow Reserve, Myocardial ,Cateterização cardíaca ,Injections, Intra-Arterial ,adenosine ,Area Under Curve ,Injections, Intravenous ,Cardiology ,Aortic pressure ,Vasodilatadores ,Female ,Cardiology and Cardiovascular Medicine ,medicine.medical_specialty ,Revascularization ,03 medical and health sciences ,contrast medium ,Predictive Value of Tests ,Internal medicine ,medicine ,Humans ,Arterial Pressure ,Instantaneous wave-free ratio ,Aged ,business.industry ,Reproducibility of Results ,medicine.disease ,instantaneous wave-free ratio ,hyperemia ,Surgery ,Contrast medium ,Blood pressure ,ROC Curve ,Doença das artérias coronárias ,business - Abstract
International audience; OBJECTIVES: This study compared the diagnostic performance with adenosine-derived fractional flow reserve (FFR) \textless/=0.8 of contrast-based FFR (cFFR), resting distal pressure (Pd)/aortic pressure (Pa), and the instantaneous wave-free ratio (iFR). BACKGROUND: FFR objectively identifies lesions that benefit from medical therapy versus revascularization. However, FFR requires maximal vasodilation, usually achieved with adenosine. Radiographic contrast injection causes submaximal coronary hyperemia. Therefore, intracoronary contrast could provide an easy and inexpensive tool for predicting FFR. METHODS: We recruited patients undergoing routine FFR assessment and made paired, repeated measurements of all physiology metrics (Pd/Pa, iFR, cFFR, and FFR). Contrast medium and dose were per local practice, as was the dose of intracoronary adenosine. Operators were encouraged to perform both intracoronary and intravenous adenosine assessments and a final drift check to assess wire calibration. A central core lab analyzed blinded pressure tracings in a standardized fashion. RESULTS: A total of 763 subjects were enrolled from 12 international centers. Contrast volume was 8 +/- 2 ml per measurement, and 8 different contrast media were used. Repeated measurements of each metric showed a bias \textless0.005, but a lower SD (less variability) for cFFR than resting indexes. Although Pd/Pa and iFR demonstrated equivalent performance against FFR \textless/=0.8 (78.5% vs. 79.9% accuracy; p = 0.78; area under the receiver-operating characteristic curve: 0.875 vs. 0.881; p = 0.35), cFFR improved both metrics (85.8% accuracy and 0.930 area; p \textless 0.001 for each) with an optimal binary threshold of 0.83. A hybrid decision-making strategy using cFFR required adenosine less often than when based on either Pd/Pa or iFR. CONCLUSIONS: cFFR provides diagnostic performance superior to that of Pd/Pa or iFR for predicting FFR. For clinical scenarios or health care systems in which adenosine is contraindicated or prohibitively expensive, cFFR offers a universal technique to simplify invasive coronary physiological assessments. Yet FFR remains the reference standard for diagnostic certainty as even cFFR reached only approximately 85% agreement.
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- 2016
23. Stenting in unprotected left main coronary artery: Immediate and follow-up results
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Park, Seung-Jung, Park, Seong-Wook, Hong, Myeong-Ki, Cheong, Sang-Sig, Kim, Jae-Joong, and Lee, Cheol-Whan
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- 1997
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24. Non-invasive risk assessment and prediction of cardiac outcomes in patients with congestive heart failure or myocardial infarction.
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Kim JY, Park YJ, Park SJ, Kim J, Park KM, On YK, Kim JS, Nam GB, Lee YS, Kim DH, Ahn M, Shin DG, Kim NH, Namgung J, Park YM, and Park HS
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Background: Heart Rate Turbulence (HRT) and T-wave alternans (TWA), recognized as promising non-invasive markers for ventricular tachyarrhythmias and cardiac death, have been studied predominantly in Western populations, specifically in patients with myocardial infarction (MI) or heart failure (HF) with reduced ejection fraction (EF)., Objective: We investigated the clinical implications of HRT and TWA in predicting adverse cardiac events, including cardiac death, ventricular tachyarrhythmia, and HF-related hospitalization (HFH)., Methods: The K-REDEFINE study, a prospective, observational, multicenter analysis at 26 tertiary hospitals in South Korea, investigated the prognostic implications of Holter-based variables including HRT and TWA in 1,116 patients with acute MI or HF (60.8±12.9 years, 76.3% males). All participants underwent 24-hour Holter recording within 6.8±16.5 days after hospitalization. The primary composite outcome included cardiac death, ventricular tachyarrhythmias, and HFH., Results: During a 4.3±1.2year follow-up, impaired HRT demonstrated the most powerful predictive value for the composite (adjusted hazard ratio [aHR]=3.41, 95% confidence interval [CI]=2.27-5.13) or individual events: cardiac death (aHR=4.08, 95% CI=2.17-7.70), ventricular tachyarrhythmia (aHR=3.72, 95% CI=1.29-10.77), and HFH (aHR=4.32, 95% CI=2.25-8.28). The predictive power of abnormal HRT remained consistently significant across subgroups of MI and HF, or across varying degree of EF. When combined with reduced EF (<50%), the predictive power was further enhanced. However, abnormal TWA was significantly associated only with the composite outcome (aHR=1.51, 95% CI=1.06-2.16)., Conclusions: K-REDEFINE study identified abnormal HRT, mostly assessed within one month after hospitalization, as a significant predictor not only for cardiac death and ventricular tachyarrhythmia but also for HFH., (Copyright © 2024. Published by Elsevier Inc.)
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- 2024
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25. The Risk and Reversibility of Osimertinib-related Cardiotoxicity in a Real-World Population.
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Bak M, Park H, Lee SH, Lee N, Ahn MJ, Ahn JS, Jung HA, Park S, Cho J, Kim J, Park SJ, Chang SA, Lee SC, Park SW, and Kim EK
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Introduction: While osimertinib, a third-generation epidermal growth factor receptor tyrosine kinase inhibitor, as the first-line therapy for metastatic non-small cell lung cancer (NSCLC) has shown significant survival benefits, concerns have arisen regarding its potential cardiotoxicity, particularly in real-world clinical settings. We aimed to investigate the incidence, risk factors, and reversibility of osimertinib-related cardiotoxicity., Methods: We analyzed 1,126 NSCLC patients treated with osimertinib from May 2016 to April 2023 in two cancer centers. Osimertinib-related cardiotoxicity was defined as a composite of osimertinib-related cardiac dysfunction (ORCD), newly developed arrhythmia, and cardiac death. Total follow-up duration was 20.6 (10.8-35.2) months., Results: The osimertinib was administered for a median of 12.4 months. The incidence of osimertinib-related cardiotoxicity was 4.7%. Advanced age (adjusted hazard ratio with 95% confidence interval; 1.07 [1.04-1.09], P < 0.001), a history of heart failure (HF; 3.35 [1.67-9.64], P = 0.025), atrial fibrillation (AF; 3.42 [1.27-9.22], P = 0.015), and baseline low left ventricle strain (0.87 [0.79-0.96], P = 0.005) were independently associated with development of cardiotoxicity. The recovery rate of ORCD was 82.4%, which did not differ between patients who discontinued medication and those who did not., Conclusion: In real-world practice, the incidence of osimertinib-related cardiotoxicity was 4.7%, including 3.4% for ORCD requiring cardiologic intervention, which is higher than previously reported. Given the long-term medication of osimertinib and increased mortality associated with cardiotoxicity, vigilant monitoring is crucial, especially in patients with advanced age, history of HF, AF, or decreased baseline LV strain., (Copyright © 2024. Published by Elsevier Inc.)
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- 2024
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26. Nanotherapeutic kidney cell-specific targeting to ameliorate acute kidney injury.
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Funahashi Y, Park SH, Hebert JF, Eiwaz MB, Munhall AC, Groat T, Zeng L, Kim J, Choi HS, and Hutchens MP
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- Animals, Humans, Nanoparticles, Male, Disease Models, Animal, Mice, Mice, Inbred C57BL, Low Density Lipoprotein Receptor-Related Protein-2 metabolism, Acute Kidney Injury drug therapy, Acute Kidney Injury pathology, Acute Kidney Injury prevention & control, Dexamethasone pharmacology, Kidney Tubules, Proximal drug effects, Kidney Tubules, Proximal pathology, Kidney Tubules, Proximal metabolism, Epithelial Cells drug effects, Epithelial Cells metabolism
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Acute kidney injury (AKI) increases the risk of in-hospital death, adds to expense of care, and risk of early chronic kidney disease. AKI often follows an acute event such that timely treatment could ameliorate AKI and potentially reduce the risk of additional disease. Despite therapeutic success of dexamethasone in animal models, clinical trials have not demonstrated broad success. To improve the safety and efficacy of dexamethasone for AKI, we developed and characterized a novel, kidney-specific nanoparticle enabling specific within-kidney targeting to proximal tubular epithelial cells provided by the megalin ligand cilastatin. Cilastatin and dexamethasone were complexed to H-Dot nanoparticles, which were constructed from generally recognized as safe components. Cilastatin/Dexamethasone/H-Dot nanotherapeutics were found to be stable at plasma pH and demonstrated salutary release kinetics at urine pH. In vivo, they were specifically biodistributed to the kidney and bladder, with 75% recovery in the urine and with reduced systemic toxicity compared to native dexamethasone. Cilastatin complexation conferred proximal tubular epithelial cell specificity within the kidney in vivo and enabled dexamethasone delivery to the proximal tubular epithelial cell nucleus in vitro. The Cilastatin/Dexamethasone/H-Dot nanotherapeutic improved kidney function and reduced kidney cellular injury when administered to male C57BL/6 mice in two translational models of AKI (rhabdomyolysis and bilateral ischemia reperfusion). Thus, our design-based targeting and therapeutic loading of a kidney-specific nanoparticle resulted in preservation of the efficacy of dexamethasone, combined with reduced off-target disposition and toxic effects. Hence, our study illustrates a potential strategy to target AKI and other diseases of the kidney., (Published by Elsevier Inc.)
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- 2024
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27. Volume-Adjusted Annular Sizing of Balloon-Expandable Transcatheter Heart Valves for Severe Bicuspid Aortic Valve Stenosis.
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Lim SM, Ahn JM, Kang DY, Jo HH, Lee JM, Park YS, Park DW, and Park SJ
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- Humans, Treatment Outcome, Heart Valve Diseases diagnostic imaging, Heart Valve Diseases physiopathology, Heart Valve Diseases surgery, Male, Female, Aged, Recovery of Function, Hemodynamics, Heart Valve Prosthesis, Aortic Valve Stenosis diagnostic imaging, Aortic Valve Stenosis surgery, Aortic Valve Stenosis physiopathology, Aortic Valve diagnostic imaging, Aortic Valve surgery, Aortic Valve physiopathology, Aortic Valve abnormalities, Balloon Valvuloplasty, Prosthesis Design, Bicuspid Aortic Valve Disease surgery, Bicuspid Aortic Valve Disease physiopathology, Bicuspid Aortic Valve Disease diagnostic imaging, Severity of Illness Index, Transcatheter Aortic Valve Replacement instrumentation, Transcatheter Aortic Valve Replacement adverse effects
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- 2024
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28. Vitamin D deficiency as a risk factor for sudden cardiac arrest: A multicenter case-control study.
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Lee MJ, Jung H, Shin SD, Ro YS, Park JH, Roh YI, Jung WJ, Park JO, Park SM, Kim SC, Shin J, Kim YW, Hong JY, Ryu HH, Kim SJ, Park JH, Kim WY, Lee GT, and Oh SB
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- Humans, Male, Female, Middle Aged, Case-Control Studies, Risk Assessment, Aged, Risk Factors, Vitamin D Deficiency blood, Vitamin D Deficiency epidemiology, Vitamin D Deficiency complications, Vitamin D Deficiency diagnosis, Vitamin D blood, Vitamin D analogs & derivatives, Death, Sudden, Cardiac epidemiology, Death, Sudden, Cardiac etiology, Death, Sudden, Cardiac prevention & control, Out-of-Hospital Cardiac Arrest blood, Out-of-Hospital Cardiac Arrest diagnosis, Out-of-Hospital Cardiac Arrest epidemiology, Out-of-Hospital Cardiac Arrest physiopathology, Biomarkers blood, Registries
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Background and Aims: Vitamin D is known to influence the risk of cardiovascular disease, which is a recognized risk factor for sudden cardiac arrest (SCA). However, the relationship between vitamin D and SCA is not well understood. Therefore, this study aims to investigate the association between vitamin D and SCA in out-of-hospital cardiac arrest (OHCA) patients compared to healthy controls., Methods and Results: Using the Phase II Cardiac Arrest Pursuit Trial with Unique Registration and Epidemiologic Surveillance (CAPTURES II) registry, a 1:1 propensity score-matched case-control study was conducted between 2017 and 2020. Serum 25-hydroxyvitamin D (vitamin D) levels in patients with OHCA (454 cases) and healthy controls (454 cases) were compared after matching for age, sex, cardiovascular risk factors, and lifestyle behaviors. The mean vitamin D levels were 14.5 ± 7.6 and 21.3 ± 8.3 ng/mL among SCA cases and controls, respectively. Logistic regression analysis was used adjusting for cardiovascular risk factors, lifestyle behaviors, corrected serum calcium levels, and estimated glomerular filtration rate (eGRF). The adjusted odds ratio (aOR) for vitamin D was 0.89 (95% confidence interval [CI] 0.87-0.91). The dose-response relationship demonstrated that vitamin D deficiency was associated with SCA incidence (severe deficiency, aOR 10.87, 95% CI 4.82-24.54; moderate deficiency, aOR 2.24, 95% CI 1.20-4.20)., Conclusion: Vitamin D deficiency was independently and strongly associated with an increased risk of SCA, irrespective of cardiovascular and lifestyle factors, corrected calcium levels, and eGFR., (Copyright © 2024 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.)
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- 2024
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29. Predictive Value of Modified Frailty Index, Sarcopenia, Prognostic Nutritional Index, and Geriatric Nutritional Risk Index for Postoperative Complications in Oblique Lumbar Interbody Fusion Over 60 Years.
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Kim JY, Lee YS, Ko MJ, and Park SW
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- Humans, Aged, Male, Female, Middle Aged, Prognosis, Aged, 80 and over, Predictive Value of Tests, Risk Factors, Nutritional Status, Retrospective Studies, Risk Assessment methods, Spinal Fusion adverse effects, Postoperative Complications epidemiology, Postoperative Complications etiology, Sarcopenia epidemiology, Lumbar Vertebrae surgery, Geriatric Assessment methods, Frailty diagnosis, Frailty epidemiology, Nutrition Assessment
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Objective: Elderly patients undergoing spinal surgery are at an increased risk of morbidity and mortality. Evaluating frailty and preoperative status is crucial for predicting postoperative outcomes. This study aimed to assess the predictive value of the modified Frailty Index (mFI), sarcopenia, Prognostic Nutritional Index (PNI), and Geriatric Nutritional Risk Index (GNRI) in determining postoperative complications in patients undergoing oblique lumbar interbody fusion (OLIF) over 60 years., Methods: Preoperative risk factors were assessed using 11 variables, including mFI, PNI, and GNRI. Complication rates were compared among nonfrail (mFI=0; n=50), prefrail (mFI=0.09-0.18; n=144), and frail (mFI ≥0.27; n=80) patients. Demographic and perioperative variables were compared between the complication and noncomplication groups. The incidence of complications was the primary outcome measure., Results: Complications occurred in 36 of 274 patients (13.1%). The frail group exhibited a significantly higher incidence of pneumonia than the nonfrail and prefrail groups. The complication group displayed significant differences in several variables, including age, fusion level, albumin level, lymphocyte count, platelet count, creatinine level, and estimated blood loss. Moreover, mFI, PNI, and GNRI differed significantly between the complication and noncomplication groups., Conclusions: MFI, PNI, and GNRI can be useful for predicting postoperative morbidity and mortality in patients undergoing OLIF. These comprehensive assessment methods enable the identification of high-risk patients and the formulation of tailored strategies to enhance postoperative outcomes. Integrating mFI, PNI, and GNRI into the preoperative evaluation process can help health care providers proactively manage high-risk patients, thus improving the overall quality of care for elderly individuals undergoing OLIF., (Copyright © 2024. Published by Elsevier Inc.)
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- 2024
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30. Validation Study for the N Descriptor of the Newly Proposed Ninth Edition of the TNM Staging System Proposed by the International Association for the Study of Lung Cancer.
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Kim IH, Lee GD, Choi S, Kim HR, Kim YH, Kim DK, Park SI, and Yun JK
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- Humans, Male, Female, Retrospective Studies, Middle Aged, Aged, Carcinoma, Non-Small-Cell Lung pathology, Carcinoma, Non-Small-Cell Lung classification, Carcinoma, Non-Small-Cell Lung mortality, Carcinoma, Non-Small-Cell Lung surgery, Adult, Aged, 80 and over, Survival Rate, Lung Neoplasms pathology, Lung Neoplasms classification, Lung Neoplasms mortality, Lung Neoplasms surgery, Neoplasm Staging standards, Neoplasm Staging methods
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Introduction: The aim of this study was to validate the discriminatory ability and clinical utility of the N descriptor of the newly proposed ninth edition of the TNM staging system for lung cancer in a large independent cohort., Methods: We retrospectively analyzed patients who underwent curative surgery for NSCLC between January 2004 and December 2019. The N descriptor of patients included in this study was retrospectively reclassified based on the ninth edition of the TNM classification. Survival analysis was performed using the log-rank test and Cox proportional hazard model to compare adjacent N categories., Results: A total of 6649 patients were included in this study. The median follow-up period was 54 months. According to the newly proposed ninth edition N classification, 5573 patients (83.8%), 639 patients (9.6%), 268 patients (4.0%), and 169 patients (2.5%) were classified into the clinical N0, N1, N2a, and N2b categories and 4957 patients (74.6%), 744 patients (11.2%), 567 patients (8.5%), and 381 patients (5.7%) were classified into the pathologic N0, N1, N2a, and N2b categories, respectively. The prognostic differences between all adjacent clinical and pathologic N categories were highly significant in terms of both overall survival and recurrence-free survival., Conclusions: We validated the clinical utility of the newly proposed ninth edition N classification for both clinical and pathologic stages in NSCLC. The new N classification revealed clear prognostic separation between all categories (N0, N1, N2a, and N2b) in terms of both overall survival and recurrence-free survival., Competing Interests: Disclosure The authors declare no confict of interest., (Copyright © 2024 International Association for the Study of Lung Cancer. Published by Elsevier Inc. All rights reserved.)
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- 2024
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31. Artificial intelligence-based quantitative coronary angiography of major vessels using deep-learning.
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In Kim Y, Roh JH, Kweon J, Kwon H, Chae J, Park K, Lee JH, Jeong JO, Kang DY, Lee PH, Ahn JM, Kang SJ, Park DW, Lee SW, Lee CW, Park SW, Park SJ, and Kim YH
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- Humans, Male, Female, Retrospective Studies, Middle Aged, Aged, Coronary Vessels diagnostic imaging, Coronary Artery Disease diagnostic imaging, Deep Learning, Coronary Angiography methods, Artificial Intelligence
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Background: Quantitative coronary angiography (QCA) offers objective and reproducible measures of coronary lesions. However, significant inter- and intra-observer variability and time-consuming processes hinder the practical application of on-site QCA in the current clinical setting. This study proposes a novel method for artificial intelligence-based QCA (AI-QCA) analysis of the major vessels and evaluates its performance., Methods: AI-QCA was developed using three deep-learning models trained on 7658 angiographic images from 3129 patients for the precise delineation of lumen boundaries. An automated quantification method, employing refined matching for accurate diameter calculation and iterative updates of diameter trend lines, was embedded in the AI-QCA. A separate dataset of 676 coronary angiography images from 370 patients was retrospectively analyzed to compare AI-QCA with manual QCA performed by expert analysts. A match was considered between manual and AI-QCA lesions when the minimum lumen diameter (MLD) location identified manually coincided with the location identified by AI-QCA. Matched lesions were evaluated in terms of diameter stenosis (DS), MLD, reference lumen diameter (RLD), and lesion length (LL)., Results: AI-QCA exhibited a sensitivity of 89% in lesion detection and strong correlations with manual QCA for DS, MLD, RLD, and LL. Among 995 matched lesions, most cases (892 cases, 80%) exhibited DS differences ≤10%. Multiple lesions of the major vessels were accurately identified and quantitatively analyzed without manual corrections., Conclusion: AI-QCA demonstrates promise as an automated tool for analysis in coronary angiography, offering potential advantages for the quantitative assessment of coronary lesions and clinical decision-making., Competing Interests: Declaration of competing interest Jihoon Kweon, Jung-Min Ahn, Young-Hak Kim report a relationship of consulting and advisory with Medipixel. All other authors declare no conflict of interest., (Copyright © 2024 The Author(s). Published by Elsevier B.V. All rights reserved.)
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- 2024
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32. Preventive percutaneous coronary intervention versus optimal medical therapy alone for the treatment of vulnerable atherosclerotic coronary plaques (PREVENT): a multicentre, open-label, randomised controlled trial.
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Park SJ, Ahn JM, Kang DY, Yun SC, Ahn YK, Kim WJ, Nam CW, Jeong JO, Chae IH, Shiomi H, Kao HL, Hahn JY, Her SH, Lee BK, Ahn TH, Chang KY, Chae JK, Smyth D, Mintz GS, Stone GW, and Park DW
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- Humans, Male, Female, Middle Aged, Aged, Treatment Outcome, New Zealand, Republic of Korea, Taiwan epidemiology, Japan, Myocardial Infarction, Acute Coronary Syndrome therapy, Percutaneous Coronary Intervention methods, Coronary Artery Disease therapy, Plaque, Atherosclerotic
- Abstract
Background: Acute coronary syndrome and sudden cardiac death are often caused by rupture and thrombosis of lipid-rich atherosclerotic coronary plaques (known as vulnerable plaques), many of which are non-flow-limiting. The safety and effectiveness of focal preventive therapy with percutaneous coronary intervention of vulnerable plaques in reducing adverse cardiac events are unknown. We aimed to assess whether preventive percutaneous coronary intervention of non-flow-limiting vulnerable plaques improves clinical outcomes compared with optimal medical therapy alone., Methods: PREVENT was a multicentre, open-label, randomised controlled trial done at 15 research hospitals in four countries (South Korea, Japan, Taiwan, and New Zealand). Patients aged 18 years or older with non-flow-limiting (fractional flow reserve >0·80) vulnerable coronary plaques identified by intracoronary imaging were randomly assigned (1:1) to either percutaneous coronary intervention plus optimal medical therapy or optimal medical therapy alone, in block sizes of 4 or 6, stratified by diabetes status and the performance of percutaneous coronary intervention in a non-study target vessel. Follow-up continued annually in all enrolled patients until the last enrolled patient reached 2 years after randomisation. The primary outcome was a composite of death from cardiac causes, target-vessel myocardial infarction, ischaemia-driven target-vessel revascularisation, or hospitalisation for unstable or progressive angina, assessed in the intention-to-treat population at 2 years. Time-to-first-event estimates were calculated with the Kaplan-Meier method and were compared with the log-rank test. This report is the principal analysis from the trial and includes all long-term analysed data. The trial is registered at ClinicalTrials.gov, NCT02316886, and is complete., Findings: Between Sept 23, 2015, and Sept 29, 2021, 5627 patients were screened for eligibility, 1606 of whom were enrolled and randomly assigned to percutaneous coronary intervention (n=803) or optimal medical therapy alone (n=803). 1177 (73%) patients were men and 429 (27%) were women. 2-year follow-up for the primary outcome assessment was completed in 1556 (97%) patients (percutaneous coronary intervention group n=780; optimal medical therapy group n=776). At 2 years, the primary outcome occurred in three (0·4%) patients in the percutaneous coronary intervention group and in 27 (3·4%) patients in the medical therapy group (absolute difference -3·0 percentage points [95% CI -4·4 to -1·8]; p=0·0003). The effect of preventive percutaneous coronary intervention was directionally consistent for each component of the primary composite outcome. Serious clinical or adverse events did not differ between the percutaneous coronary intervention group and the medical therapy group: at 2 years, four (0·5%) versus ten (1·3%) patients died (absolute difference -0·8 percentage points [95% CI -1·7 to 0·2]) and nine (1·1%) versus 13 (1·7%) patients had myocardial infarction (absolute difference -0·5 percentage points [-1·7 to 0·6])., Interpretation: In patients with non-flow-limiting vulnerable coronary plaques, preventive percutaneous coronary intervention reduced major adverse cardiac events arising from high-risk vulnerable plaques, compared with optimal medical therapy alone. Given that PREVENT is the first large trial to show the potential effect of the focal treatment for vulnerable plaques, these findings support consideration to expand indications for percutaneous coronary intervention to include non-flow-limiting, high-risk vulnerable plaques., Funding: The CardioVascular Research Foundation, Abbott, Yuhan Corp, CAH-Cordis, Philips, and Infraredx, a Nipro company., Competing Interests: Declaration of interests S-JP reports research grants and speaker fees from Abbott Vascular, Medtronic, Daiichi-Sankyo, ChongKunDang Pharm, Daewoong Pharm, and Edwards. D-YK reports speaker fees from Abbott Vascular, Daiichi-Sankyo, Viatris, Boryoung, and Daewoong Pharm. Y-KA reports research grants from Boston Scientific, Medtronic, Abbott, and DioMedical. C-WN reports a research grant from Abbott. J-OJ reports speaker fees from Medtronic. HS reports speaker fees from Abbott Vascular and Boston Scientific. H-LK reports grants and speaker fees from Abbott Vascular and Boston Scientific. J-YH reports research grants and speaker fees from Abbott Vascular, Biotronik, Boston Scientific, and Medtronic. K-YC reports research grant from Biotronik and Medtronik. GSM reports honoraria from Boston Scientific, Abbott, SpectraWave, and Gentuity. GWS reports speaker fees from Medtronic, Pulnovo, Infraredx, Abiomed, Abbott, Amgen, and Boehringer Ingelheim; consultant fees from Daiichi Sankyo, Ablative Solutions, CorFlow, Apollo Therapeutics, Cardiomech, Gore, Robocath, Miracor, Vectorious, Abiomed, Valfix, TherOx, HeartFlow, Neovasc, Ancora, Elucid Bio, Occlutech, Impulse Dynamics, Adona Medical, Millennia Biopharma, and Oxitope; equity or stock options from Ancora, Cagent, Applied Therapeutics, Biostar family of funds, SpectraWave, Orchestra Biomed, Aria, Cardiac Success, Valfix, and Xenter; and grants from Abbott, Abiomed, Bioventrix, Cardiovascular Systems, Phillips, Biosense-Webster, Shockwave, Vascular Dynamics, Pulnovo, and V-wave outside the submitted work; and GWS's daughter is an employee at IQVIA. D-WP reports research grants and speaker fees from Abbott Vascular, Medtronic, Daiichi-Sankyo, Edwards Lifescience, ChongKunDang Pharm, and Daewoong Pharm. All other authors declare no competing interests relevant to the contents of this paper., (Copyright © 2024 Elsevier Ltd. All rights reserved.)
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- 2024
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33. When and why PM 2.5 is high in Seoul, South Korea: Interpreting long-term (2015-2021) ground observations using machine learning and a chemical transport model.
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Lee HM, Kim NK, Ahn J, Park SM, Lee JY, and Kim YP
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Seoul has high PM
2.5 concentrations and has not attained the national annual average standard so far. To understand the reasons, we analyzed long-term (2015-2021) hourly observations of aerosols (PM2.5 , NO3 - , NH4 + , SO4 2- , OC, and EC) and gases (CO, NO2 , and SO2 ) from Seoul and Baekryeong Island, a background site in the upwind region of Seoul. We applied the weather normalization method for meteorological conditions and a 3-dimensional chemical transport model, GEOS-Chem, to identify the effect of policy implementation and aerosol formation mechanisms. The monthly mean PM2.5 ranges between about 20 μg m-3 (warm season) and about 40 μg m-3 (cold season) at both sites, but the annual decreasing rates were larger at Seoul than at Baengnyeong (-0.7 μg m-3 a-1 vs. -1.8 μg m-3 a-1 ) demonstrating the effectiveness of the local air quality policies including the Special Act on Air Quality in the Seoul Metropolitan Area (SAAQ-SMA) and the seasonal control measures. The weather-normalized monthly mean data shows the highest PM2.5 concentration in March and the lowest concentration in August throughout the 7 years with NO3 - accounting for about 40 % of the difference between the two months at both sites. Taking together with the GEOS-Chem model results, which reproduced the elevated NO3 - in March, we concluded the elevated atmospheric oxidant level increases in HNO3 (which is not available from the observation) and the still low temperatures in March promote rapid production of NO3 - . We used Ox (≡ O3 + NO2 ) from the observation and OH from the GEOS-Chem as a proxy for the atmospheric oxidant level which can be a source of uncertainty. Thus, direct observations of OH and HNO3 are needed to provide convincing evidence. This study shows that reducing HNO3 levels through atmospheric oxidant level control in the cold season can be effective in PM2.5 mitigation in Seoul., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier B.V. All rights reserved.)- Published
- 2024
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34. Prognostic Value of Poststenting Fractional Flow Reserve After Imaging-Guided Optimal Stenting.
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Ahn JM, Kang DY, Kim JH, Choi Y, Kim H, Lee J, Park DW, and Park SJ
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- Humans, Prognosis, Treatment Outcome, Coronary Angiography, Stents, Fractional Flow Reserve, Myocardial, Coronary Artery Disease diagnostic imaging, Coronary Artery Disease therapy, Percutaneous Coronary Intervention adverse effects
- Abstract
Background: Prognostic value of poststenting fractional flow reserve (FFR) remains uncertain in patients undergoing an imaging-guided optimal stenting strategy., Objectives: The authors evaluated the prognostic value of poststenting FFR according to the intracoronary imaging-guided lesion preparation, stent sizing, and postdilation (iPSP) strategy to optimize stent outcomes., Methods: Poststenting FFR assessment was performed in 1,108 lesions in 1,005 patients from the IRIS-FFR registry. The primary outcome was target vessel failure (TVF), a composite of cardiac death, target vessel myocardial infarction, and target vessel revascularization at 5 years., Results: At the index procedure, 326 lesions (29.4%) were treated using all 3 parts of the iPSP strategy. In the overall population, poststenting FFR was significantly associated with the risk of TVF at 5 years (per 0.01 increase of FFR, adjusted HR [aHR]: 0.94; 95% CI: 0.90-0.98; P = 0.004). Significant interaction was detected between poststenting FFR and the iPSP strategy on the risk of TVF at 5 years (P = 0.045 for interaction). In the iPSP group, poststenting FFR was not associated with the risk of TVF at 5 years (per 0.01 increase of FFR, aHR: 1.00; 95% CI: 0.96-1.05; P = 0.95), whereas a significant association between poststenting FFR and TVF at 5 years was observed in the no iPSP group (per 0.01 increase of FFR, aHR: 0.94; 95% CI: 0.90-0.99; P = 0.009)., Conclusions: Poststenting FFR showed a significant association with cardiac events. However, its prognostic value appeared to be limited after the application of an imaging-guided optimal stenting strategy., Competing Interests: Funding Support and Author Disclosures This research was supported by a grant from the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (grant number: HC19C0022). The authors have reported that they have no relationships relevant to the contents of this paper to disclose., (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)
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- 2024
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35. Development of a machine learning model for identifying the optimal situation favoring double-level osteotomy over single-level high tibial osteotomy.
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Nam HS, Pei Yuik Ho J, Park SY, Cho JH, and Lee YS
- Subjects
- Humans, Retrospective Studies, Male, Female, Middle Aged, Osteoarthritis, Knee surgery, Knee Joint surgery, Knee Joint diagnostic imaging, Knee Joint physiopathology, Osteotomy methods, Machine Learning, Tibia surgery, Tibia diagnostic imaging
- Abstract
Background: This study aimed to develop a machine learning (ML) model to identify the optimal situation wherein double-level osteotomy (DLO) is favored for severe varus knees by analyzing unfavorable outcomes. This study hypothesized that there are the most favorable algorithms and contributing factors for identifying the optimal situation favoring DLO over opening-wedge high tibial osteotomy (OWHTO)., Methods: Data were retrospectively collected from patients who underwent OWHTO (505 knees). Unfavorable outcome parameters were defined as follows: (1) medial proximal tibial angle (MPTA) > 95°, (2) joint line convergence angle (JLCA) > 4° (insufficient medial release), (3) JLCA < 0° (medial instability), (4) recurrence of varus deformity, and (5) lateral hinge fracture. The input data for the ML model included demographic data and preoperative radiological and intra-operative factors. The ML model was used to evaluate overall and to evaluate each unfavorable outcome. Interpretation by the model was performed by SHapley Additive exPlanations., Results: The unfavorable group had a larger JLCA and MPTA preoperatively than the favorable group in the conventional comparison. The light gradient boosting machine (LGBM) demonstrated the highest AUC of 0.66 and F-1 score of 0.72 among the ML algorithms. In the overall assessment, the preoperative weight-bearing line ratio (WBLR) was the factor that contributed the most, followed by the preoperative JLCA and the ΔWBLR. ΔWBLR and the preoperative JLCA were the contributing factors for each outcome., Conclusions: The LGBM model was superior in predicting the optimal situations favoring DLO over OWHTO. Preoperative WBLR, preoperative JLCA, and ΔWBLR significantly contributed to the unfavorable outcomes overall and for each outcome in the ML model., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier B.V. All rights reserved.)
- Published
- 2024
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36. Dibutyl phthalate disrupts glycogen synthase kinase 3α essential for sperm motility.
- Author
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Park SH and Gye MC
- Subjects
- Male, Mice, Animals, Sperm Proteins, Hydrogen Peroxide metabolism, Reactive Oxygen Species metabolism, Semen, Spermatozoa, Sperm Motility, Dibutyl Phthalate toxicity, Dibutyl Phthalate metabolism
- Abstract
To unravel the toxic mechanism of phthalate ester plasticizer endocrine disruptor in spermatozoa, we examined the effect of dibutyl phthalate (DBP) on the stability and inhibitory phosphorylation of glycogen synthase kinase 3α (GSK3α), a protein kinase crucial for sperm motility in mice. In DBP-treated spermatozoa, reactive oxygen species (ROS) and lipid peroxide were significantly increased. In computer-assisted sperm analysis, DBP at concentrations of 10 - 100 μg/mL significantly decreased total motility and progressive motility of spermatozoa. On western blots, DBP decreased p-GSK3α(Ser21) and increased p-GSK3α(Tyr279) in spermatozoa. Similarly, hydrogen peroxide decreased p-GSK3α(Ser21) but not p-GSK3α(Tyr279) in spermatozoa. Immunofluorescent labeling demonstrated that DBP markedly decreased immunoreactivities of GSK3α and p-GSK3α(Ser21) but increased immunoreactivity of p-GSK3α(Tyr279) in spermatozoa. DBP at a concentration of 100 μg/mL significantly increased phosphatase activity in spermatozoa. Calyculin A, a protein phosphatase 1 and 2 A inhibitor, markedly increased p-GSK3α(Ser21) and sperm motility and attenuated a DBP-induced decrease of p-GSK3α(Ser21) and sperm motility. On western blot, 1-100 μg/mL DBP decreased GSK3α in spermatozoa. On immunoprecipitation western blot, DBP at 10 - 100 μg/mL increased polyubiquitinated sperm proteins including GSK3α. The MG115, proteasome inhibitor attenuated degradation of GSK3α in DBP-treated spermatozoa. Hydrogen peroxide at 10 μM increased polyubiquitinated sperm proteins, suggesting that DBP may increase ubiquitination of GSK3α via ROS induction. Together, DBP may decrease the cellular amount of GSK3α through the ubiquitin-proteasome pathway and p-GSK3α(Ser21) through ROS generation and activation of protein phosphatases, impairing sperm motility., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)
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- 2024
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37. Biocompatibility and Bioactivity of a Dual-Cured Resin-Based Calcium Silicate Cement: In Vitro and in vivo Evaluation.
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Park SH, Ye JR, Asiri NM, Chae YK, Choi SC, and Nam OH
- Subjects
- Rats, Animals, Silicates pharmacology, Silicates chemistry, Oxides pharmacology, Oxides chemistry, Drug Combinations, Silicate Cement chemistry, Aluminum Compounds pharmacology, Aluminum Compounds chemistry, Materials Testing, Calcium, Calcium Compounds pharmacology, Calcium Compounds chemistry
- Abstract
Introduction: This study aimed to assess the biocompatibility and bioactivity of a dual-cured resin-based calcium silicate cement in vitro and in vivo., Methods: For in vitro analyses, standardized samples were prepared using TheraCal LC, TheraCal PT, and ProRoot MTA. The amount of residual monomer released from TheraCal LC and TheraCal PT was assessed using liquid chromatography/mass spectrometry. Calcium ion release from the materials was evaluated using inductively coupled plasma-optical emission spectroscopy. Scanning electron microscopy and energy-dispersive X-ray spectroscopy were used to determine the calcium weight volume in the materials. For in vivo analysis, a rat direct pulp capping model with TheraCal LC, TheraCal PT, and ProRoot MTA groups (n = 16 per group) was used. The rats were euthanized after 7 or 28 days, and histological and immunohistochemical analyses (CD68 and DSPP) were performed., Results: Bisphenol A-glycidyl methacrylate and polyethylene glycol dimethacrylate release from TheraCal PT was lower than that from TheraCal LC (P < .05). Similar results were obtained for calcium-ion release and calcium weight volume, with ProRoot MTA showing the highest values. In the in vivo evaluation, TheraCal PT showed significantly greater hard tissue formation than TheraCal LC (P < .017). TheraCal PT showed lower CD68 expression and greater DSPP expression than TheraCal LC (P < .017). There were no significant differences in the expression of CD68 or DSPP between the TheraCal PT and ProRoot MTA groups., Conclusions: Within the limitations of this study, the biocompatibility and bioactivity of TheraCal PT could be comparable to those of ProRoot MTA., (Copyright © 2023 American Association of Endodontists. Published by Elsevier Inc. All rights reserved.)
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- 2024
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38. Impact of Target Lesion Revascularization on Long-Term Mortality After Percutaneous Coronary Intervention for Left Main Disease.
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Kim TO, Kang DY, Ahn JM, Kim MJ, Lee PH, Kim H, Choi Y, Lee J, Lee JM, Jo HH, Park YS, Lim SM, Park SJ, and Park DW
- Subjects
- Humans, Treatment Outcome, Vascular Surgical Procedures, Coronary Artery Disease diagnostic imaging, Coronary Artery Disease therapy, Percutaneous Coronary Intervention adverse effects, Drug-Eluting Stents
- Abstract
Background: Although target lesion revascularization (TLR) after percutaneous coronary intervention (PCI) for unprotected left main coronary artery (LMCA) disease is not rare, its timing of occurrence and prognostic impact on long-term mortality is uncertain., Objectives: This study sought to investigate TLR incidence over time and its impact on mortality after PCI with drug-eluting stents (DES) for LMCA disease., Methods: Using a pooled data from 4 multicenter observational registries (IRIS-DES [Interventional Cardiology Research Incorporation Society-Drug-Eluting Stents], IRIS-MAIN [Interventional Cardiology Research Incorporation Society-Left MAIN Revascularization], MAIN-COMPARE [Revascularization for Unprotected Left Main Coronary Artery Stenosis: Comparison of Percutaneous Coronary Angioplasty Versus Surgical Revascularization], and PRECOMBAT [PREmier of Randomized COMparison of Bypass Surgery versus AngioplasTy Using Drug-Eluting Stent in Patients with Left Main Coronary Artery Disease]), we evaluated 1,397 patients with LMCA disease treated with DES and available long-term mortality data. The association between TLR and the 10-year risk of mortality was examined by multivariable Cox proportional hazards regression, with TLR as a time-varying covariate., Results: During maximum follow-up of 10 years (median 6.8 years), TLR occurred in 118 patients and its 10-year cumulative incidence was 10.8%. TLR mostly occurred within 2 years after initial PCI and decreased over time: early-stage TLR (within 2 years) in 73 (61.9%) patients and late-stage TLR (beyond 2 years) in 45 (38.1%) patients. Among all TLR patients, 23 patients underwent coronary artery bypass grafting and 95 underwent repeat PCI. In the time-varying multivariable Cox model, the presence of TLR was not significantly associated with an increased risk of mortality (adjusted HR: 0.90; 95% CI: 0.50-1.63; P = 0.73)., Conclusions: Although the incidence of ischemia-driven TLR was mostly common within 2 years after left main PCI, TLR occurred steadily during the 10-year follow-up period. However, given that such patients were optimally revascularized, the prognostic impact of TLR on mortality was not substantial. (Evaluation of the First, Second, and New Drug-Eluting Stents in Routine Clinical Practice [IRIS-DES]; NCT01186133; Observational Study for Left Main Disease Treatment [IRIS-MAIN]; NCT01341327; Ten-Year Outcomes of Stents Versus Coronary-Artery Bypass Grafting for Left Main Coronary Artery Disease [MAIN COMPARE]; NCT02791412; Bypass Surgery Versus Angioplasty Using Sirolimus-Eluting Stent in Patients With Left Main Coronary Artery Disease [PRECOMBAT]; NCT00422968)., Competing Interests: Funding Support and Author Disclosures This work was partly supported by a grant from the Cardiovascular Research Foundation of South Korea. The sponsors played no role in this study. There was no industry involvement in the design or conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, and approval of the manuscript; or decision to submit the manuscript for publication. The authors have reported that they have no relationships relevant to the contents of this paper to disclose., (Copyright © 2024 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.)
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- 2024
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39. A Technique to Deliver Conformal External Beam Radiation for Squamous Carcinoma of the Penile Glans and Urethra.
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Byun SJ, Kim M, Oh YK, Park SG, Choi E, and Kim B
- Subjects
- Male, Humans, Radiotherapy Planning, Computer-Assisted methods, Urethra, Water, Radiotherapy Dosage, Penile Neoplasms radiotherapy, Carcinoma, Squamous Cell radiotherapy
- Abstract
This study presents an approach to external beam radiation therapy for treating penile cancer using a small water bath. This modified technique involves the use of an acrylic, cuboid-shaped water bath with dimensions 6 × 6 × 8 cm
3 . The water bath is filled with readily available saline solution maintained at room temperature. The patient is positioned in the prone position, and the penis is placed within the water bath. The isocenter is set at the center of the water bath, and bilateral beams are positioned at 89.1° and 270.9°. The proposed technique was evaluated based on dose calculations, demonstrating a clinical target volume dose with a Dmax of 103.5% and a Dmin of 100.0% of the prescribed dose. Additionally, the method showed a low organs-at-risk dose, with a Dmean of only 1% for the testicles. The treatment zone inside the water bath also showed a uniform dose distribution. This technique not only offers high treatment efficiency and more accurate dose distribution to the targeted area but also provides additional benefits, including reduced toxicity to organs at risk and increased device utilization efficiency. In conclusion, the proposed modified external beam radiation therapy method presents a promising alternative for patients with penile cancer, enhancing treatment precision and safety., Competing Interests: Disclosures None., (Copyright © 2023 American Society for Radiation Oncology. Published by Elsevier Inc. All rights reserved.)- Published
- 2024
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40. Frequency, Predictors, and Clinical Impact of Valvular and Perivalvular Thrombus After Transcatheter Aortic Valve Replacement.
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Choi Y, Ahn JM, Kang DY, Kim HJ, Kim H, Lee J, Kim M, Park J, Kim KW, Koo HJ, Yang DH, Jung SC, Kim B, Anthony Wong YT, Simon Lam CC, Yin WH, Wei J, Lee YT, Kao HL, Lin MS, Ko TY, Kim WJ, Kang SH, Lee SA, Kim DH, Lee JH, Park SJ, and Park DW
- Subjects
- Humans, Anticoagulants therapeutic use, Aortic Valve diagnostic imaging, Aortic Valve surgery, Aortic Valve pathology, Four-Dimensional Computed Tomography adverse effects, Platelet Aggregation Inhibitors, Risk Factors, Treatment Outcome, Aortic Valve Stenosis diagnostic imaging, Aortic Valve Stenosis surgery, Heart Valve Prosthesis adverse effects, Thromboembolism etiology, Thrombosis diagnostic imaging, Thrombosis etiology, Thrombosis prevention & control, Transcatheter Aortic Valve Replacement adverse effects, Transcatheter Aortic Valve Replacement methods
- Abstract
Background: Subclinical aortic valve complex (valvular and perivalvular) thrombus is not rare after transcatheter aortic valve replacement (TAVR). The risk factors and clinical implications of these findings remain uncertain., Objectives: This study sought to evaluate the frequency, predictors, and clinical outcome of aortic valve complex thrombus after TAVR., Methods: In the ADAPT-TAVR (Anticoagulation Versus Dual Antiplatelet Therapy for Prevention of Leaflet Thrombosis and Cerebral Embolization After Transcatheter Aortic Valve Replacement) trial comparing edoxaban vs dual antiplatelet therapy in TAVR patients without an indication for chronic anticoagulation, the frequency of valvular (subclinical leaflet thrombus) and perivalvular (supravalvular, subvalvular, and sinus of Valsalva) thrombus was evaluated by 4-dimensional computed tomography at 6 months. The association of these phenomena with new cerebral thromboembolism on brain magnetic resonance imaging, neurologic and neurocognitive dysfunction, and clinical outcomes was assessed., Results: Among 211 patients with 6-month computed tomography evaluations, 91 patients (43.1%) had thrombus at any aortic valve complex, 30 (14.2%) patients had leaflet thrombus, and 78 (37.0%) patients had perivalvular thrombus. A small maximum diameter of the stent at the valve level and low body surface area were independent predictors of aortic valve complex and perivalvular thrombus, and decreased renal function was an independent predictor of leaflet thrombus. No significant differences were observed in new cerebral lesions, neurologic or neurocognitive functions, or clinical outcomes among patients with or without valvular or perivalvular thrombus., Conclusions: Subclinical aortic valve complex (valvular and perivalvular) thrombus was common in patients who had undergone successful TAVR. However, these imaging phenomena were not associated with new cerebral thromboembolism, neurologic or neurocognitive dysfunction, or adverse clinical outcomes. (Anticoagulation Versus Dual Antiplatelet Therapy for Prevention of Leaflet Thrombosis and Cerebral Embolization After Transcatheter Aortic Valve Replacement [ADAPT-TAVR]; NCT03284827)., Competing Interests: Funding Support and Author Disclosures This work was partly supported by a grant from the Cardiovascular Research Foundation and Daiichi Sankyo Korea Co, Ltd. Dr S-J Park has received grants and personal fees from Abbott Vascular; has received grants from Daiichi-Sankyo, ChongKunDang Pharm, and Daewoong Pharm; and has received grants and personal fees from Edwards outside the submitted work. Dr D-W Park has received grants from Daiichi-Sankyo, ChongKunDang Pharm, and Daewoong Pharm; has received personal fees from Edwards; has received grants and personal fees from Abbott Vascular; and has received personal fees from Medtronic outside the submitted work. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose., (Copyright © 2023 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.)
- Published
- 2023
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41. Sulfur isotope-based source apportionment and control mechanisms of PM 2.5 sulfate in Seoul, South Korea during winter and early spring (2017-2020).
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Lee G, Ahn J, Park SM, Moon J, Park R, Sim MS, Choi H, Park J, and Ahn JY
- Abstract
High level of particulate matter (PM) concentrations are a major environmental concern in Seoul, South Korea, especially during winter and early spring. Sulfate is a major component of PM and induces severe environmental pollution, such as acid precipitation. Previous studies have used numerical models to constrain the relative contributions of domestic and trans-boundary sources to PM
2.5 sulfate concentration in South Korea. Because of the scarce measurement result of δ34 S for PM2.5 sulfate in South Korea, poorly defined δ34 S value of domestic sulfur sources, and no application of sulfur isotope fractionation during sulfate formation in previous observation-based studies, source apportionment results conducted by model studies have not been corroborated from independent chemical observations. Here, we examined the δ34 S of PM2.5 in Seoul and domestic sulfur sources, and considered the sulfur isotope fractionation for accurate source apportionment constraint. Accordingly, domestic and trans-boundary sulfur sources accounted for approximately (16-32) % and (68-84) % of the sulfate aerosols in Seoul, respectively, throughout the winter and early spring of 2017-2020. Air masses passing through north-eastern China had relatively low sulfate concentrations, enriched δ34 S, and a low domestic source contribution. Those passing through south-eastern China had relatively a high sulfate concentrations, depleted δ34 S, and high domestic source contribution. Furthermore, elevated PM2.5 sulfate concentrations (>10 μg m-3 ) were exclusively associated with a weak westerly wind speed of <3 m s-1 . From December 2019 to March 2020, Seoul experienced relatively low levels of PM2.5 sulfate, which might be attributed to favorable weather conditions rather than the effects of COVID-19 containment measures. Our results demonstrate the potential use of δ34 S for accurate source apportionment and for identifying the crucial role of regional air mass transport and meteorological conditions in PM2.5 sulfate concentration. Furthermore, the data provided can be essential for relevant studies and policy-making in East Asia., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 Elsevier B.V. All rights reserved.)- Published
- 2023
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42. Everolimus-Eluting Stents or Bypass Surgery for Multivessel Disease in Diabetics: The BEST Extended Follow-Up Study.
- Author
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Kim H, Kang DY, Ahn JM, Lee J, Choi Y, Hur SH, Park HJ, Tresukosol D, Kang WC, Kwon HM, Rha SW, Lim DS, Jeong MH, Lee BK, Huang H, Lim YH, Bae JH, Kim BO, Ong TK, Ahn SG, Chung CH, Park DW, and Park SJ
- Subjects
- Humans, Follow-Up Studies, Everolimus adverse effects, Treatment Outcome, Stents, Coronary Artery Disease diagnostic imaging, Coronary Artery Disease surgery, Drug-Eluting Stents adverse effects, Percutaneous Coronary Intervention adverse effects, Myocardial Infarction etiology, Diabetes Mellitus diagnosis
- Abstract
Background: Diabetes mellitus is associated with more complex coronary artery diseases. Coronary artery bypass grafting (CABG) is a preferred revascularization strategy over percutaneous coronary intervention (PCI) in diabetics with multivessel coronary artery disease (MVD)., Objectives: This study sought to examine the different prognostic effects of revascularization strategies according to the diabetes status from the randomized BEST (Randomized Comparison of Coronary Artery Bypass Surgery and Everolimus-Eluting Stent Implantation in the Treatment of Patients With Multivessel Coronary Artery Disease) trial., Methods: Patients (n = 880) with MVD were randomly assigned to undergo PCI with an everolimus-eluting stent vs CABG stratified by diabetics (n = 363) and nondiabetics (n = 517). The primary endpoint was the composite of death, myocardial infarction, or target vessel revascularization during a median follow-up of 11.8 years (IQR: 10.6-12.5 years)., Results: In diabetics, the primary endpoint rate was significantly higher in the PCI group than in the CABG group (43% and 32%; HR: 1.53; 95% CI: 1.12-2.08; P = 0.008). However, in nondiabetics, no significant difference was found between the groups (PCI group, 29%; CABG group, 29%; HR: 0.97; 95% CI: 0.67-1.39; P = 0.86; P
interaction = 0.009). Irrespective of the presence of diabetes, no significant between-group differences were found in the rate of a safety composite of death, myocardial infarction, or stroke and mortality rate. However, the rate of any repeat revascularization was significantly higher in the PCI group than in the CABG group., Conclusions: In diabetics with MVD, CABG was associated with better clinical outcomes than PCI. However, the mortality rate was similar between PCI and CABG irrespective of diabetes status during an extended follow-up. (Ten-Year Outcomes of Randomized Comparison of Coronary Artery Bypass Surgery and Everolimus-Eluting Stent Implantation in the Treatment of Patients With Multivessel Coronary Artery Disease [BEST Extended], NCT05125367; Randomized Comparison of Coronary Artery Bypass Surgery and Everolimus-Eluting Stent Implantation in the Treatment of Patients With Multivessel Coronary Artery Disease [BEST], NCT00997828)., Competing Interests: Funding Support and Author Disclosures This research was supported by a grant from the Korea Health Technology R and D Project through the Korea Health Industry Development Institute funded by the Ministry of Health and Welfare, Republic of Korea (grant number HC19C0022). The authors have reported that they have no relationships relevant to the contents of this paper to disclose., (Copyright © 2023 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.)- Published
- 2023
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43. Difference in the outcomes of anterior tenting and wrapping techniques for acellular dermal matrix coverage in prepectoral breast reconstruction.
- Author
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Sohn SM, Lee HC, Park SH, and Yoon ES
- Subjects
- Humans, Female, Mastectomy methods, Retrospective Studies, Postoperative Complications etiology, Acellular Dermis, Breast Neoplasms complications, Mammaplasty methods, Breast Implantation methods, Breast Implants adverse effects
- Abstract
Background: Acellular dermal matrices (ADMs) play an essential role in prepectoral implant-based breast reconstructions; however, the most appropriate method for ADMs is unknown., Methods: We conducted a retrospective analysis of our institutional database. Patients who underwent mastectomy and prepectoral breast reconstruction using tissue expanders or breast implants covered with ADMs between March 2018 and June 2021 were included. Patient characteristics, postoperative complications, and long-term outcomes were investigated., Results: In total, 112 patients (126 breasts) were included. The anterior tenting and wrapping techniques were used in the reconstruction of 32 (25.3%) and 94 (74.7%) breasts, respectively. Using propensity score matching, nine breasts were selected for each technique within the direct-to-implant reconstruction group, while 16 breasts were selected for each technique within the 2-stage reconstruction group. The choice of technique (anterior vs. wrapping) in implementing ADM did not generate any significant differences in postoperative complications, including seroma formation and capsular contracture, for the direct-to-implant and 2-stage reconstruction groups. Regarding the direct-to-implant reconstruction group, the average postoperative drain volume was less in the anterior tenting group than that in the wrapping group (anterior tenting vs. wrapping; 495.09 ± 156.118 mL vs. 673.43 ± 307.954 mL, p = 0.006), but the difference was insignificant after propensity score matching., Conclusion: We report our experience with covering prosthetic devices with ADMs during postmastectomy breast reconstruction. No differences in the postoperative drain volume or postoperative outcomes were found between the study groups. Future studies are needed to determine the method that provides the most satisfactory results., Competing Interests: Declaration of Competing Interest None., (Copyright © 2023 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.)
- Published
- 2023
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44. Pattern of pericardial calcification determines mid-term postoperative outcomes after pericardiectomy in chronic constrictive pericarditis.
- Author
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Lee YH, Kim SM, Kim EK, Park SJ, Lee SC, Park SW, Jeong DS, and Chang SA
- Subjects
- Humans, Pericardiectomy adverse effects, Retrospective Studies, Calcium, Risk Factors, Pericarditis, Constrictive diagnostic imaging, Pericarditis, Constrictive surgery, Heart Failure etiology
- Abstract
Objectives: Although pericardiectomy is an effective treatment for constrictive pericarditis (CP), clinical outcomes are not always successful. Pericardial calcification is a unique finding in CP, although the amount and localization of calcification can vary. We investigated how the pattern and amount of pericardial calcification affect mid-term postoperative outcomes after pericardiectomy to treat CP., Methods: All patients of total pericardiectomy in our hospital from 2010 to 2020 were enrolled. Preoperative Computed tomography (CT) scans of 98 consecutive patients were available and analyzed. Medical records were reviewed retrospectively. Cardiovascular events were defined as cardiovascular death or hospitalization associated with a heart failure symptom, and all-cause events were defined as any event that required admission. CT scans were analyzed, and the volume and localization pattern of peri-calcification were determined. Pericardium calcium scores are presented using Agatston scores., Results: Of the 98 patients, 25 (25.5%) were hospitalized with heart failure symptoms after pericardiectomy. The median follow-up duration for all patients was 172 weeks. The group with a cardiovascular event had a lower calcium score than patients without an event. Multivariate Cox proportional analysis showed that high ln(calcium score+1) before pericardiectomy was a dependent predictor of cardiovascular event (hazard ratio, 0.90; p = 0.04) after pericardiectomy. When we set the cut-off value (ln(calcium score+1) = 7.22), there was a significant difference in cardiovascular events in the multivariate Cox proportional analysis (p = 0.04)., Conclusion: A low burden of pericardial calcification was associated with a high rate of mid-term clinical events after pericardiectomy to treat CP., (Copyright © 2023 Elsevier B.V. All rights reserved.)
- Published
- 2023
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45. 2023 HRS/APHRS/LAHRS guideline on cardiac physiologic pacing for the avoidance and mitigation of heart failure.
- Author
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Chung MK, Patton KK, Lau CP, Dal Forno ARJ, Al-Khatib SM, Arora V, Birgersdotter-Green UM, Cha YM, Chung EH, Cronin EM, Curtis AB, Cygankiewicz I, Dandamudi G, Dubin AM, Ensch DP, Glotzer TV, Gold MR, Goldberger ZD, Gopinathannair R, Gorodeski EZ, Gutierrez A, Guzman JC, Huang W, Imrey PB, Indik JH, Karim S, Karpawich PP, Khaykin Y, Kiehl EL, Kron J, Kutyifa V, Link MS, Marine JE, Mullens W, Park SJ, Parkash R, Patete MF, Pathak RK, Perona CA, Rickard J, Schoenfeld MH, Seow SC, Shen WK, Shoda M, Singh JP, Slotwiner DJ, Sridhar ARM, Srivatsa UN, Stecker EC, Tanawuttiwat T, Tang WHW, Tapias CA, Tracy CM, Upadhyay GA, Varma N, Vernooy K, Vijayaraman P, Worsnick SA, Zareba W, and Zeitler EP
- Subjects
- Child, Humans, Bundle of His, Treatment Outcome, Cardiac Conduction System Disease, Electrocardiography methods, Cardiac Resynchronization Therapy methods, Heart Failure therapy
- Abstract
Cardiac physiologic pacing (CPP), encompassing cardiac resynchronization therapy (CRT) and conduction system pacing (CSP), has emerged as a pacing therapy strategy that may mitigate or prevent the development of heart failure (HF) in patients with ventricular dyssynchrony or pacing-induced cardiomyopathy. This clinical practice guideline is intended to provide guidance on indications for CRT for HF therapy and CPP in patients with pacemaker indications or HF, patient selection, pre-procedure evaluation and preparation, implant procedure management, follow-up evaluation and optimization of CPP response, and use in pediatric populations. Gaps in knowledge, pointing to new directions for future research, are also identified., (Copyright © 2023 The Heart Rhythm Society, the European Heart Rhythm Association, the Asia Pacific Heart Rhythm Society, and the Latin American Heart Rhythm Society. Published by Elsevier Inc. All rights reserved.)
- Published
- 2023
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46. CT Coronary Angiography and Dynamic CT Myocardial Perfusion for Detection of Cardiac Allograft Vasculopathy.
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Ahn Y, Koo HJ, Hyun J, Lee SE, Jung SH, Park DW, Ahn JM, Kang DY, Park SJ, Hwang HS, Kang JW, Yang DH, and Kim JJ
- Subjects
- Humans, Coronary Angiography methods, Computed Tomography Angiography methods, Predictive Value of Tests, Tomography, X-Ray Computed methods, Myocardium, Allografts, Perfusion, Coronary Stenosis, Coronary Artery Disease diagnostic imaging, Myocardial Perfusion Imaging methods
- Abstract
Background: Cardiac allograft vasculopathy (CAV) is a major obstacle limiting long-term graft survival. Effective noninvasive surveillance modalities reflecting both coronary artery and microvascular components of CAV are needed., Objectives: The authors evaluated the diagnostic performance of dynamic computed tomography-myocardial perfusion imaging (CT-MPI) and coronary computed tomography angiography (CCTA) for CAV., Methods: A total of 63 heart transplantation patients underwent combined CT-MPI and CCTA plus invasive coronary angiography (ICA) with intravascular ultrasonography (IVUS) between December 2018 and October 2021. The median interval between CT-MPI and heart transplantation was 4.3 years. Peak myocardial blood flow (MBF) of the whole myocardium (MBF
global ) and minimum MBF (MBFmin ) among the 16 segments according to the American Heart Association model, except the left ventricular apex, were calculated from CT-MPI. CCTA was assessed qualitatively, and the degree of coronary artery stenosis was recorded. CAV was diagnosed based on both ICA (ISHLT criteria) and IVUS. Patients were followed up for a median time of 2.3 years after CT-MPI and a median time of 5.7 years after transplantation., Results: Among the 63 recipients, 35 (55.6%) had diagnoses of CAV. The median MBFglobal and MBFmin were significantly lower in patients with CAV (128.7 vs 150.4 mL/100 mL/min; P = 0.014; and 96.9 vs 122.8 mL/100 mL/min; P < 0.001, respectively). The combined use of coronary artery stenosis on CCTA and MBFmin showed the highest diagnostic performance with an area under the curve of 0.886 (sensitivity: 74.3%, specificity: 96.4%, positive predictive value: 96.3%, and negative predictive value: 75.0%)., Conclusions: The combination of CT-MPI and CCTA demonstrated excellent diagnostic performance for the detection of CAV. One-stop evaluation of the coronary artery and microvascular components involved in CAV using combined CCTA and CT-MPI may be a potent noninvasive screening method for early detection of CAV., Competing Interests: Funding Support and Author Disclosures This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (No. 2022R1A5A1022977). The authors have reported that they have no relationships relevant to the contents of this paper to disclose., (Copyright © 2023 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.)- Published
- 2023
- Full Text
- View/download PDF
47. Quantitative analysis of facial symmetry and animation following intraoral orthodromic temporalis transfer in facial paralysis.
- Author
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Park H, Kim DJ, Chung JH, Yoon ES, and Park SH
- Subjects
- Humans, Smiling, Facial Expression, Temporal Muscle surgery, Facial Paralysis surgery, Plastic Surgery Procedures
- Abstract
This study aimed to quantitatively analyze the degree and vector of commissure excursion following intraoral orthodromic temporalis transfer. Patients with unilateral facial paralysis who underwent intraoral temporalis transfer were included. Intra-oral coronoidectomy was followed by submucosa tunneling through two vertical intraoral incisions to fixate the temporalis tendon to the perioral location. Oral commissure excursion, upper lip and commissure height differences, and smile angle were measured. Postoperatively, the symmetry of commissure excursion improved in repose (affected side: 114.6 ± 7.0 mm, non-affected side: 115.2 ± 4.9 mm, p = 0.134), while asymmetry arose in smiling (affected side: 30.7 ± 3.4 mm, non-affected side: 34.5 ± 4.4 mm, p = 0.001). Furthermore, the postoperative smile angle demonstrated insufficient vertical movement on the affected side during smiling (affected side: 115.6 ± 5.8°, non-affected side: 118.4 ± 4.9°, p = 0.002) but no significant difference in repose (p = 0.134). Within the limitations of the study it seems that intraoral orthodromic temporalis transfer yields excellent resting symmetry, but smile asymmetry may occur owing to insufficient oral commissure excursion. Nevertheless, as a minimally invasive surgery, this technique can obviate visible scars and benefit patients wishing for the same and can have excellent resting symmetry., (Copyright © 2023 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.)
- Published
- 2023
- Full Text
- View/download PDF
48. Chemistry revolutionizes genetics and epigenetics.
- Author
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Yoshida M and Park SB
- Subjects
- Epigenesis, Genetic, Epigenomics
- Abstract
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
- Published
- 2023
- Full Text
- View/download PDF
49. Myokine musclin alleviates lipid accumulation in 3T3-L1 adipocytes through PKA/p38-mediated upregulation of lipolysis and suppression of lipogenesis.
- Author
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Choi SW, Oh H, Park SY, Cho W, Abd El-Aty AM, Hacimuftuoglu A, Jeong JH, and Jung TW
- Subjects
- Animals, Mice, 3T3-L1 Cells, Up-Regulation, Adipocytes metabolism, Lipids pharmacology, Adipogenesis, Lipolysis, Lipogenesis
- Abstract
Musclin (MUS), an exercise-responsive myokine, has been documented to attenuate inflammation and enhance physical endurance. However, the effects of MUS on differentiation and related molecular mechanisms in adipocytes have not yet been studied. In this study, we found that treatment with MUS attenuated lipid accumulation in fully differentiated 3T3-L1 cells. Furthermore, MUS treatment enhanced lipolysis assessed by glycerol release, and caused apoptosis, whereas it reduced the expression of lipogenic proteins, such as PPARγ and processed SREBP1. Treatment with MUS augmented phosphorylated PKA expression, whereas suppressed p38 phosphorylation in 3T3-L1 adipocytes. H89, a selective PKA inhibitor reduced the effects of MUS on lipogenic lipid accumulation as well as lipolysis except for apoptosis. These results suggest that MUS promotes lipolysis and suppresses lipogenesis through a PKA/p38-dependent pathway, thereby ameliorating lipid deposition in cultured adipocytes. The current study offers the potential of MUS as a therapeutic approach for treating obesity with few side effects., Competing Interests: Declaration of competing interest None., (Copyright © 2022 Elsevier Inc. All rights reserved.)
- Published
- 2023
- Full Text
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50. Hydrogel-based thermosensor using peptide nucleic acid and PEGylated graphene oxide.
- Author
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Park SJ, Park SM, Kim WK, and Lee J
- Subjects
- Hydrogels, Water, Polyethylene Glycols chemistry, Nucleic Acid Hybridization, Peptide Nucleic Acids chemistry
- Abstract
Developing a ready-to-use miniaturized thermosensor is a great challenge due to its individual use on a large scale for daily business such as food industry and healthcare. Herein, a polyethylene glycol (PEG)-modified graphene oxide (GO)-based hydrogel thermosensor was established with a fluorescent dye-labeled peptide nucleic acid (F-PNA). The size-tunable hydrogel with high water content and sufficient solidity allowed free movement of the oligonucleotides through the pores and improved usability for handling the sensor. In the PEG-GO hydrogel, the DNA/F-PNA duplex could be denatured by increasing the temperature, followed by selective PNA capture on the PEG-GO. Using this principle, the PEG-GO hydrogel exhibited a change in the fluorescence signal of F-PNA in a temperature-dependent manner, allowing real-time visualization of temperature on a large scale. The temperature detection range of this system can be adjusted by designing the PNA strands based on the melting temperature of the DNAzyme/PNA duplex. Its sensing specificity and detection range could be increased and broadened by observing multi-color detection using PNA probes labeled with different fluorescent dyes of different lengths in a single hydrogel. In addition, the hydrogel platform is easy to store for long time periods via dehydration and can be restored with the addition of water, allowing easy transport, storage, and use of the thermosensor in everyday life., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2022 The Authors. Published by Elsevier B.V. All rights reserved.)
- Published
- 2023
- Full Text
- View/download PDF
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